psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L304	R:R:Q54	10.65	Yes	No	0	2	4
2	R:R:I57	R:R:L304	5.71	No	Yes	0	4	2
3	R:R:L59	R:R:S62	4.5	No	No	0	5	6
4	R:R:F60	R:R:L64	7.31	No	No	0	5	6
5	R:R:I308	R:R:L61	5.71	No	No	0	5	5
6	R:R:F117	R:R:S62	5.28	No	No	0	3	6
7	R:R:H307	R:R:S62	4.18	Yes	No	0	4	6
8	R:R:F68	R:R:L64	3.65	No	No	0	5	6
9	R:R:S112	R:R:Y65	7.63	No	Yes	3	8	7
10	R:R:V116	R:R:Y65	3.79	No	Yes	0	7	7
11	R:R:L311	R:R:Y65	4.69	No	Yes	0	5	7
12	R:R:F314	R:R:Y65	4.13	Yes	Yes	3	6	7
13	R:R:C318	R:R:Y65	4.03	No	Yes	0	8	7
14	R:R:T66	R:R:V116	4.76	No	No	0	5	7
15	R:R:F68	R:R:I67	5.02	No	No	0	5	4
16	R:R:L69	R:R:S315	4.5	No	No	0	7	5
17	R:R:F70	R:R:P71	4.33	Yes	No	0	7	5
18	R:R:F70	R:R:F74	6.43	Yes	No	0	7	6
19	R:R:F70	R:R:V109	3.93	Yes	No	0	7	6
20	R:R:F70	R:R:L113	9.74	Yes	No	0	7	9
21	R:R:F74	R:R:I78	5.02	No	No	0	6	4
22	R:R:F74	R:R:L106	7.31	No	No	0	6	7
23	R:R:D105	R:R:N77	6.73	Yes	No	0	9	9
24	R:R:L106	R:R:N77	6.87	No	No	0	7	9
25	R:R:N77	R:R:P321	13.03	No	No	0	9	9
26	R:R:I80	R:R:S325	9.29	Yes	No	5	9	7
27	R:R:F326	R:R:I80	5.02	Yes	Yes	5	7	9
28	R:R:F331	R:R:I80	7.54	Yes	Yes	5	9	9
29	R:R:V82	R:R:Y338	6.31	No	Yes	0	3	5
30	R:R:F331	R:R:V83	9.18	Yes	Yes	0	9	8
31	R:R:K334	R:R:V83	4.55	Yes	Yes	0	5	8
32	R:R:V83	R:R:Y338	3.79	Yes	Yes	0	8	5
33	R:R:M91	R:R:N84	4.21	Yes	No	2	6	7
34	R:R:D95	R:R:N84	10.77	Yes	No	2	7	7
35	R:R:K334	R:R:N84	4.2	Yes	No	2	5	7
36	R:R:S86	R:R:Y338	3.82	No	Yes	8	4	5
37	R:R:K342	R:R:S86	7.65	No	No	8	5	4
38	R:R:F87	R:R:K334	6.2	No	Yes	0	5	5
39	R:R:F87	R:R:L337	9.74	No	No	0	5	4
40	R:R:D95	R:R:M91	9.7	Yes	Yes	2	7	6
41	R:R:K171	R:R:M91	5.76	No	Yes	2	4	6
42	R:R:P94	R:R:T92	6.99	No	No	0	8	7
43	R:R:D95	R:R:T92	8.67	Yes	No	0	7	7
44	R:R:I93	R:R:Y97	3.63	No	Yes	0	6	7
45	R:R:I93	R:R:R169	10.02	No	No	0	6	7
46	R:R:A174	R:R:I93	4.87	No	No	0	7	6
47	R:R:F98	R:R:P94	4.33	No	No	0	8	8
48	R:R:D95	R:R:K334	5.53	Yes	Yes	2	7	5
49	R:R:K171	R:R:L96	4.23	No	No	2	4	6
50	R:R:L96	R:R:R175	6.07	No	No	2	6	4
51	R:R:W150	R:R:Y97	11.58	Yes	Yes	9	7	7
52	R:R:M151	R:R:Y97	4.79	No	Yes	0	9	7
53	R:R:D154	R:R:Y97	9.2	No	Yes	0	8	7
54	R:R:S177	R:R:Y97	3.82	No	Yes	9	5	7
55	R:R:F98	R:R:M151	6.22	No	No	0	8	9
56	R:R:F147	R:R:N100	14.5	Yes	No	4	8	9
57	R:R:C178	R:R:N100	9.45	No	No	4	7	9
58	R:R:N100	R:R:W182	7.91	No	No	4	9	9
59	R:R:D105	R:R:L101	10.86	Yes	No	1	9	9
60	R:R:L101	R:R:L148	5.54	No	No	1	9	8
61	R:R:L101	R:R:N320	4.12	No	Yes	1	9	9
62	R:R:D105	R:R:S144	4.42	Yes	No	0	9	9
63	R:R:D105	R:R:S317	8.83	Yes	No	0	9	8
64	R:R:D105	R:R:N320	12.12	Yes	Yes	1	9	9
65	R:R:F136	R:R:I107	5.02	No	No	10	4	7
66	R:R:I107	R:R:N140	15.58	No	No	10	7	8
67	R:R:L108	R:R:N140	4.12	Yes	No	0	7	8
68	R:R:L108	R:R:M141	5.65	Yes	No	0	7	7
69	R:R:L108	R:R:S144	4.5	Yes	No	0	7	9
70	R:R:L108	R:R:S317	6.01	Yes	No	0	7	8
71	R:R:D111	R:R:L137	8.14	No	No	0	7	6
72	R:R:F314	R:R:S112	11.89	Yes	No	3	6	8
73	R:R:E115	R:R:H307	8.62	No	Yes	0	6	4
74	R:R:E115	R:R:N310	11.83	No	No	3	6	5
75	R:R:E115	R:R:F314	4.66	No	Yes	3	6	6
76	R:R:F117	R:R:V116	9.18	No	No	0	3	7
77	R:R:H120	R:R:N118	3.83	Yes	No	0	3	5
78	R:R:H120	R:R:Y123	4.36	Yes	Yes	6	3	8
79	R:R:H120	R:R:Y124	15.24	Yes	No	6	3	3
80	R:R:D125	R:R:R122	3.57	No	No	0	7	4
81	R:R:Y123	R:R:Y124	14.89	Yes	No	6	8	3
82	R:R:C130	R:R:Y123	4.03	No	Yes	6	9	8
83	R:R:M133	R:R:Y123	7.18	No	Yes	0	5	8
84	R:R:C130	R:R:Y124	4.03	No	No	6	9	3
85	R:R:D125	R:R:I126	12.59	No	No	0	7	8
86	R:R:I126	R:R:L129	4.28	No	No	0	8	6
87	R:R:F193	R:R:L135	8.53	No	No	0	4	6
88	R:R:F136	R:R:N140	8.46	No	No	10	4	8
89	R:R:L137	R:R:M141	4.24	No	No	0	6	7
90	R:R:Q138	R:R:Y142	15.78	No	Yes	7	5	7
91	R:R:Q138	R:R:T189	4.25	No	Yes	7	5	7
92	R:R:E218	R:R:Q138	6.37	No	No	7	5	5
93	R:R:T189	R:R:V139	6.35	Yes	No	0	7	5
94	R:R:M141	R:R:W272	4.65	No	Yes	0	7	9
95	R:R:F146	R:R:Y142	5.16	No	Yes	0	6	7
96	R:R:A188	R:R:Y142	5.34	No	Yes	0	4	7
97	R:R:T189	R:R:Y142	4.99	Yes	Yes	7	7	7
98	R:R:E218	R:R:Y142	4.49	No	Yes	7	5	7
99	R:R:F147	R:R:S143	3.96	Yes	Yes	4	8	7
100	R:R:S143	R:R:W182	13.59	Yes	No	4	7	9
101	R:R:P226	R:R:V145	3.53	No	No	0	9	8
102	R:R:F268	R:R:V145	3.93	Yes	No	11	9	8
103	R:R:V145	R:R:W272	4.9	No	Yes	11	8	9
104	R:R:F146	R:R:L221	3.65	No	No	0	6	4
105	R:R:C178	R:R:F147	4.19	No	Yes	4	7	8
106	R:R:F147	R:R:I181	12.56	Yes	No	0	8	7
107	R:R:F147	R:R:W182	9.02	Yes	No	4	8	9
108	R:R:L148	R:R:N320	9.61	No	Yes	1	8	9
109	R:R:L148	R:R:Y324	7.03	No	Yes	1	8	9
110	R:R:I229	R:R:T149	4.56	No	No	0	7	8
111	R:R:I230	R:R:T149	6.08	Yes	No	0	8	8
112	R:R:F153	R:R:W150	9.02	No	Yes	0	6	7
113	R:R:F168	R:R:W150	4.01	No	Yes	0	1	7
114	R:R:S177	R:R:W150	9.88	No	Yes	9	5	7
115	R:R:M151	R:R:Y324	4.79	No	Yes	0	9	9
116	R:R:I230	R:R:S152	4.64	Yes	No	0	8	9
117	R:R:C233	R:R:S152	5.16	No	No	0	8	9
118	R:R:S152	R:R:Y234	6.36	No	Yes	0	9	8
119	R:R:F153	R:R:I157	11.3	No	No	0	6	5
120	R:R:D154	R:R:R169	10.72	No	No	0	8	7
121	R:R:R155	R:R:Y234	8.23	No	Yes	1	9	8
122	R:R:R155	R:R:Y324	6.17	No	Yes	1	9	9
123	R:R:I157	R:R:Y156	3.63	No	Yes	0	5	8
124	R:R:A160	R:R:Y156	6.67	No	Yes	0	7	8
125	R:R:R161	R:R:Y156	4.12	No	Yes	0	6	8
126	R:R:L236	R:R:Y156	9.38	No	Yes	0	3	8
127	R:R:I237	R:R:Y156	3.63	No	Yes	0	8	8
128	R:R:F168	R:R:I157	5.02	No	No	0	1	5
129	R:R:A158	R:R:R169	6.91	No	No	0	8	7
130	R:R:C165	R:R:R161	6.96	No	No	0	6	6
131	R:R:M163	R:R:R164	7.44	No	No	0	5	4
132	R:R:H173	R:R:T170	4.11	No	No	0	3	6
133	R:R:K171	R:R:R175	7.43	No	No	2	4	4
134	R:R:L176	R:R:L180	4.15	No	No	0	1	4
135	R:R:S187	R:R:V191	4.85	No	No	0	4	7
136	R:R:P192	R:R:V191	3.53	No	No	0	4	7
137	R:R:P192	R:R:V214	3.53	No	No	0	4	4
138	R:R:F193	R:R:H197	5.66	No	No	0	4	5
139	R:R:V196	R:R:V211	8.02	No	No	0	5	4
140	R:R:V211	R:R:V214	6.41	No	No	0	4	4
141	R:R:R212	R:R:W216	8	No	No	0	3	4
142	R:R:I279	R:R:Q215	6.86	No	No	13	5	4
143	R:R:L283	R:R:Q215	5.32	Yes	No	13	5	4
144	R:R:L283	R:R:W216	13.67	Yes	No	0	5	4
145	R:R:L217	R:R:L221	8.3	No	No	0	4	4
146	R:R:N276	R:R:V219	4.43	No	No	0	8	5
147	R:R:F223	R:R:F227	15	No	No	0	9	6
148	R:R:F223	R:R:L273	6.09	No	Yes	0	9	5
149	R:R:F223	R:R:N276	9.67	No	No	0	9	8
150	R:R:P226	R:R:V225	3.53	No	No	0	9	5
151	R:R:F227	R:R:F268	7.5	No	Yes	0	6	9
152	R:R:F227	R:R:F269	12.86	No	No	0	6	5
153	R:R:G231	R:R:I230	3.53	No	Yes	0	4	8
154	R:R:F268	R:R:I230	7.54	Yes	Yes	0	9	8
155	R:R:L232	R:R:L236	4.15	No	No	12	4	3
156	R:R:I261	R:R:Y234	8.46	No	Yes	0	7	8
157	R:R:V264	R:R:Y234	3.79	No	Yes	1	8	8
158	R:R:Y234	R:R:Y324	4.96	Yes	Yes	1	8	9
159	R:R:L258	R:R:V238	4.47	No	No	0	6	5
160	R:R:R239	R:R:R243	8.53	No	No	0	3	3
161	R:R:H245	R:R:R254	5.64	No	No	0	4	6
162	R:R:H247	R:R:R248	9.03	No	No	0	3	2
163	R:R:L327	R:R:M260	4.24	No	No	0	6	8
164	R:R:I323	R:R:V264	6.14	No	No	1	7	8
165	R:R:V264	R:R:Y324	13.88	No	Yes	1	8	9
166	R:R:L319	R:R:V267	5.96	No	No	0	6	7
167	R:R:I323	R:R:V267	6.14	No	No	0	7	7
168	R:R:F268	R:R:W272	10.02	Yes	Yes	11	9	9
169	R:R:F269	R:R:L273	3.65	No	Yes	0	5	5
170	R:R:A313	R:R:W272	3.89	No	Yes	0	8	9
171	R:R:N316	R:R:W272	19.21	No	Yes	0	9	9
172	R:R:P274	R:R:V309	3.53	No	No	0	9	7
173	R:R:E275	R:R:N310	3.94	No	No	0	6	5
174	R:R:A313	R:R:E275	4.53	No	No	0	8	6
175	R:R:F278	R:R:H282	16.97	Yes	No	14	5	4
176	R:R:F278	R:R:H302	6.79	Yes	No	14	5	4
177	R:R:F278	R:R:T305	5.19	Yes	No	0	5	5
178	R:R:F278	R:R:V309	7.87	Yes	No	0	5	7
179	R:R:I279	R:R:L283	4.28	No	Yes	13	5	5
180	R:R:H282	R:R:H302	10.75	No	No	14	4	4
181	R:R:I308	R:R:L304	4.28	No	Yes	0	5	2
182	R:R:H307	R:R:L311	14.14	Yes	No	0	4	5
183	R:R:F314	R:R:N310	3.62	Yes	No	3	6	5
184	R:R:L319	R:R:S315	4.5	No	No	0	6	5
185	R:R:N316	R:R:N320	12.26	No	Yes	0	9	9
186	R:R:N320	R:R:Y324	5.81	Yes	Yes	1	9	9
187	R:R:F326	R:R:L322	6.09	Yes	No	0	7	6
188	R:R:I323	R:R:Y324	6.04	No	Yes	1	7	9
189	R:R:F331	R:R:S325	6.61	Yes	No	5	9	7
190	R:R:F326	R:R:F331	8.57	Yes	Yes	5	7	9
191	R:R:D333	R:R:R336	3.57	No	No	0	4	4
192	R:R:I339	R:R:L335	5.71	No	No	0	5	6
193	R:R:E340	R:R:R336	5.82	No	No	0	4	4
194	R:R:K342	R:R:Y338	7.17	No	Yes	8	5	5
195	R:R:K342	R:R:Q341	12.2	No	No	0	5	2
196	R:R:L59	R:R:Y55	3.52	No	No	0	5	1
197	R:R:L129	R:R:Y123	3.52	No	Yes	0	6	8
198	R:R:I181	R:R:W150	3.52	No	Yes	0	7	7
199	R:R:E329	R:R:R332	3.49	No	No	0	4	8
200	R:R:C271	R:R:S315	3.44	No	No	0	9	5
201	R:R:A104	R:R:S143	3.42	No	Yes	0	8	7
202	R:R:A104	R:R:S144	3.42	No	No	0	8	9
203	R:R:L273	R:R:P274	3.28	Yes	No	0	5	9
204	R:R:S143	R:R:S185	3.26	Yes	No	0	7	7
205	R:R:A102	R:R:I80	3.25	No	Yes	0	9	9
206	R:R:S185	R:R:V139	3.23	No	No	0	7	5
207	R:R:S280	R:R:V277	3.23	No	No	0	5	5
208	R:R:F132	R:R:F136	3.22	No	No	0	5	4
209	R:R:V139	R:R:V186	3.21	No	No	0	5	4
210	R:R:S134	R:R:T131	3.2	No	No	0	5	7
211	R:R:R332	R:R:R336	3.2	No	No	0	8	4
212	R:R:P303	R:R:Q54	3.16	No	No	0	3	4
213	R:R:A102	R:R:L81	3.15	No	No	0	9	7
214	R:R:I279	R:R:V219	3.07	No	No	0	5	5
215	R:R:F326	R:R:G76	3.01	Yes	No	0	7	7
216	R:R:F278	R:R:G306	3.01	Yes	No	0	5	4
217	R:R:L135	R:R:S134	3	No	No	0	6	5
218	R:R:L81	R:R:V103	2.98	No	No	0	7	5
219	R:R:L335	R:R:V83	2.98	No	Yes	0	6	8
220	R:R:L190	R:R:V186	2.98	No	No	0	4	4
221	R:R:L273	R:R:V277	2.98	Yes	No	0	5	5
222	R:R:L135	R:R:T189	2.95	No	Yes	0	6	7
223	R:R:L198	R:R:T194	2.95	No	No	0	1	4
224	R:R:I99	R:R:M91	2.92	No	Yes	0	6	6
225	R:R:K256	R:R:M260	2.88	No	No	0	7	8
226	R:R:I72	R:R:L322	2.85	No	No	0	5	6
227	R:R:I237	R:R:L241	2.85	No	No	0	8	8
228	R:R:C63	R:R:F117	2.79	No	No	0	4	3
229	R:R:H52	R:R:V56	2.77	No	No	0	4	2
230	R:R:L258	R:R:Q255	2.66	No	No	0	6	5
231	R:R:F132	R:R:M133	2.49	No	No	0	5	5
232	R:R:F68	R:R:L69	2.44	No	No	0	5	7
233	R:R:I114	R:R:Y123	2.42	No	Yes	0	6	8
234	R:R:G73	R:R:P321	2.03	No	No	0	8	9
235	R:R:G222	R:R:P226	2.03	No	No	0	5	9
236	R:R:C178	R:R:G179	1.96	No	No	0	7	4
237	R:R:A312	R:R:P274	1.87	No	No	0	7	9
238	R:R:G76	R:R:V75	1.84	No	No	0	7	4
239	R:R:G328	R:R:M260	1.75	No	No	0	8	8
240	R:R:G58	R:R:L61	1.71	No	No	0	3	5
241	R:R:G58	R:R:L304	1.71	No	Yes	0	3	2
242	R:R:G76	R:R:L79	1.71	No	No	0	7	6
243	R:R:A160	R:R:V240	1.7	No	No	0	7	5
244	R:R:G58	R:R:H307	1.59	No	Yes	0	3	4
245	R:R:T220	R:R:V225	1.59	No	No	0	5	5
246	R:R:A257	R:R:L241	1.58	No	No	0	8	8
247	R:R:I126	R:R:V128	1.54	No	No	0	8	3
248	R:R:I224	R:R:V219	1.54	No	No	0	4	5
249	R:R:I224	R:R:V225	1.54	No	No	0	4	5
250	R:R:I230	R:R:V265	1.54	Yes	No	0	8	7
251	R:R:I261	R:R:V238	1.54	No	No	0	7	5
252	R:R:L232	R:R:S235	1.5	No	No	12	4	3
253	R:R:L236	R:R:S235	1.5	No	No	12	3	3
254	R:R:G328	R:R:R332	1.5	No	No	0	8	8
255	R:R:L266	R:R:V265	1.49	No	No	0	5	7
256	R:R:I85	R:R:I99	1.47	No	No	0	3	6
257	R:R:A301	R:R:H302	1.46	No	No	0	5	4
258	R:R:I114	R:R:L119	1.43	No	No	0	6	5
259	R:R:I237	R:R:L159	1.43	No	No	0	8	8
260	R:R:Q285	R:R:V281	1.43	No	No	0	3	4
261	R:R:H200	R:R:V196	1.38	No	No	0	2	5
262	R:R:A244	R:R:R248	1.38	No	No	0	5	2
263	R:R:H282	R:R:V281	1.38	No	No	0	4	4
264	R:R:L283	R:R:L284	1.38	Yes	No	0	5	5
265	R:R:D210	R:R:Q215	1.31	No	No	0	3	4
266	R:R:R243	R:R:V240	1.31	No	No	0	3	5
267	R:R:F269	R:R:V270	1.31	No	No	0	5	6
268	R:R:F193	R:R:T194	1.3	No	No	0	4	4
269	R:R:H52	R:R:Q53	1.24	No	No	0	4	3
270	R:R:F87	R:R:K90	1.24	No	No	0	5	6
271	R:R:E121	R:R:H120	1.23	No	Yes	0	4	3
272	R:R:Q255	R:R:R259	1.17	No	No	0	5	5
273	R:R:R253	R:R:R254	1.07	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y65	4.854	5	3	7
2	R:R:F70	6.1075	4	0	7
3	R:R:I80	6.275	4	5	9
4	R:R:V83	5.125	4	0	8
5	R:R:M91	5.6475	4	2	6
6	R:R:D95	8.6675	4	2	7
7	R:R:Y97	6.604	5	9	7
8	R:R:D105	8.592	5	1	9
9	R:R:L108	5.07	4	0	7
10	R:R:H120	6.165	4	6	3
11	R:R:Y123	6.06667	6	6	8
12	R:R:Y142	7.152	5	7	7
13	R:R:S143	6.0575	4	4	7
14	R:R:F147	8.846	5	4	8
15	R:R:W150	7.602	5	9	7
16	R:R:Y156	5.486	5	0	8
17	R:R:T189	4.635	4	7	7
18	R:R:I230	4.666	5	0	8
19	R:R:Y234	6.36	5	1	8
20	R:R:F268	7.2475	4	11	9
21	R:R:W272	8.534	5	11	9
22	R:R:L273	4	4	0	5
23	R:R:F278	7.966	5	14	5
24	R:R:L283	6.1625	4	13	5
25	R:R:L304	5.5875	4	0	2
26	R:R:H307	7.1325	4	0	4
27	R:R:F314	6.075	4	3	6
28	R:R:N320	8.784	5	1	9
29	R:R:Y324	6.95429	7	1	9
30	R:R:F326	5.6725	4	5	7
31	R:R:F331	7.975	4	5	9
32	R:R:K334	5.12	4	2	5
33	R:R:Y338	5.2725	4	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G58	R:R:H307	13.1131	1.59	No	Yes	0	3	4
2	R:R:L69	R:R:S315	12.0117	4.5	No	No	0	7	5
3	R:R:L319	R:R:S315	16.7282	4.5	No	No	0	6	5
4	R:R:L319	R:R:V267	19.0671	5.96	No	No	0	6	7
5	R:R:I323	R:R:V267	21.3929	6.14	No	No	0	7	7
6	R:R:I323	R:R:Y324	20.013	6.04	No	Yes	1	7	9
7	R:R:N320	R:R:Y324	81.5225	5.81	Yes	Yes	1	9	9
8	R:R:N316	R:R:N320	61.4124	12.26	No	Yes	0	9	9
9	R:R:N316	R:R:W272	61.2245	19.21	No	Yes	0	9	9
10	R:R:A313	R:R:W272	42.151	3.89	No	Yes	0	8	9
11	R:R:A313	R:R:E275	40.7904	4.53	No	No	0	8	6
12	R:R:E275	R:R:N310	39.4169	3.94	No	No	0	6	5
13	R:R:E115	R:R:N310	24.3797	11.83	No	No	3	6	5
14	R:R:E115	R:R:H307	23.207	8.62	No	Yes	0	6	4
15	R:R:F74	R:R:L106	10.9167	7.31	No	No	0	6	7
16	R:R:L106	R:R:N77	12.6919	6.87	No	No	0	7	9
17	R:R:D105	R:R:N77	17.9397	6.73	Yes	No	0	9	9
18	R:R:D105	R:R:N320	35.0632	12.12	Yes	Yes	1	9	9
19	R:R:F331	R:R:V83	24.2306	9.18	Yes	Yes	0	9	8
20	R:R:K334	R:R:V83	39.2096	4.55	Yes	Yes	0	5	8
21	R:R:D95	R:R:K334	45.034	5.53	Yes	Yes	2	7	5
22	R:R:D95	R:R:T92	58.4775	8.67	Yes	No	0	7	7
23	R:R:P94	R:R:T92	60.1231	6.99	No	No	0	8	7
24	R:R:F98	R:R:P94	61.7558	4.33	No	No	0	8	8
25	R:R:F98	R:R:M151	63.3754	6.22	No	No	0	8	9
26	R:R:M151	R:R:Y324	100	4.79	No	Yes	0	9	9
27	R:R:F326	R:R:F331	12.1542	8.57	Yes	Yes	5	7	9
28	R:R:V83	R:R:Y338	10.3596	3.79	Yes	Yes	0	8	5
29	R:R:D95	R:R:M91	11.9145	9.7	Yes	Yes	2	7	6
30	R:R:M151	R:R:Y97	66.4075	4.79	No	Yes	0	9	7
31	R:R:W150	R:R:Y97	55.4454	11.58	Yes	Yes	9	7	7
32	R:R:F147	R:R:S143	20.473	3.96	Yes	Yes	4	8	7
33	R:R:A104	R:R:S143	32.0052	3.42	No	Yes	0	8	7
34	R:R:A104	R:R:S144	32.7762	3.42	No	No	0	8	9
35	R:R:L108	R:R:S144	36.4691	4.5	Yes	No	0	7	9
36	R:R:L108	R:R:M141	31.597	5.65	Yes	No	0	7	7
37	R:R:M141	R:R:W272	33.4046	4.65	No	Yes	0	7	9
38	R:R:L108	R:R:S317	10.7224	6.01	Yes	No	0	7	8
39	R:R:F136	R:R:N140	32.8604	8.46	No	No	10	4	8
40	R:R:L108	R:R:N140	36.9226	4.12	Yes	No	0	7	8
41	R:R:M133	R:R:Y123	27.1914	7.18	No	Yes	0	5	8
42	R:R:F132	R:R:M133	29.2128	2.49	No	No	0	5	5
43	R:R:F132	R:R:F136	31.2213	3.22	No	No	0	5	4
44	R:R:L129	R:R:Y123	10.8131	3.52	No	Yes	0	6	8
45	R:R:L135	R:R:T189	11.1241	2.95	No	Yes	0	6	7
46	R:R:T189	R:R:V139	24.6777	6.35	Yes	No	0	7	5
47	R:R:S185	R:R:V139	29.0509	3.23	No	No	0	7	5
48	R:R:S143	R:R:S185	30.4827	3.26	Yes	No	0	7	7
49	R:R:V145	R:R:W272	16.9226	4.9	No	Yes	11	8	9
50	R:R:P226	R:R:V145	16.7865	3.53	No	No	0	9	8
51	R:R:F268	R:R:W272	56.1257	10.02	Yes	Yes	11	9	9
52	R:R:F147	R:R:I181	19.9028	12.56	Yes	No	0	8	7
53	R:R:I181	R:R:W150	20.473	3.52	No	Yes	0	7	7
54	R:R:F268	R:R:I230	37.4927	7.54	Yes	Yes	0	9	8
55	R:R:F153	R:R:W150	27.7681	9.02	No	Yes	0	6	7
56	R:R:F168	R:R:W150	27.5607	4.01	No	Yes	0	1	7
57	R:R:I230	R:R:S152	36.9938	4.64	Yes	No	0	8	9
58	R:R:S152	R:R:Y234	37.6158	6.36	No	Yes	0	9	8
59	R:R:Y234	R:R:Y324	37.9786	4.96	Yes	Yes	1	8	9
60	R:R:F153	R:R:I157	26.1095	11.3	No	No	0	6	5
61	R:R:F168	R:R:I157	26.0901	5.02	No	No	0	1	5
62	R:R:I157	R:R:Y156	48.7593	3.63	No	Yes	0	5	8
63	R:R:A160	R:R:Y156	14.0395	6.67	No	Yes	0	7	8
64	R:R:L236	R:R:Y156	10.8001	9.38	No	Yes	0	3	8
65	R:R:I237	R:R:Y156	14.046	3.63	No	Yes	0	8	8
66	R:R:P226	R:R:V225	13.8452	3.53	No	No	0	9	5
67	R:R:I224	R:R:V225	11.4221	1.54	No	No	0	4	5
68	R:R:I224	R:R:V219	10.243	1.54	No	No	0	4	5
69	R:R:I279	R:R:V219	23.4208	3.07	No	No	0	5	5
70	R:R:I279	R:R:L283	13.4694	4.28	No	Yes	13	5	5
71	R:R:F227	R:R:F268	80.9329	7.5	No	Yes	0	6	9
72	R:R:F223	R:R:F227	47.632	15	No	No	0	9	6
73	R:R:F223	R:R:N276	19.2161	9.67	No	No	0	9	8
74	R:R:N276	R:R:V219	17.1947	4.43	No	No	0	8	5
75	R:R:F223	R:R:L273	29.0185	6.09	No	Yes	0	9	5
76	R:R:F269	R:R:L273	28.0078	3.65	No	Yes	0	5	5
77	R:R:F227	R:R:F269	31.8432	12.86	No	No	0	6	5
78	R:R:A160	R:R:V240	10.4632	1.7	No	No	0	7	5
79	R:R:L273	R:R:P274	44.6971	3.28	Yes	No	0	5	9
80	R:R:P274	R:R:V309	36.5986	3.53	No	No	0	9	7
81	R:R:F278	R:R:V309	32.5105	7.87	Yes	No	0	5	7
82	R:R:F278	R:R:H282	12.4328	16.97	Yes	No	14	5	4
83	R:R:F314	R:R:Y65	10.5734	4.13	Yes	Yes	3	6	7
84	R:R:F314	R:R:N310	13.6378	3.62	Yes	No	3	6	5
85	R:R:D105	R:R:S144	16.7995	4.42	Yes	No	0	9	9
86	R:R:D105	R:R:S317	10.7353	8.83	Yes	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8XOI_nogp

PDB Summary
PDB	8XOI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	244
Number of Links	273
Number of Hubs	33
Number of Links mediated by Hubs	131
Number of Communities	14
Number of Nodes involved in Communities	59
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	37675
Length Of Smallest Path	3
Average Path Length	13.8027
Length of Longest Path	26
Minimum Path Strength	1.405
Average Path Strength	6.31681
Maximum Path Strength	15.735
Minimum Path Correlation	0.7
Average Path Correlation	0.915952
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	45.3749
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.4499
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • steroid hormone binding • steroid binding • lipid binding • hormone binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • chromatin binding • nuclear receptor activity • nuclear steroid receptor activity • DNA-binding transcription factor activity, RNA polymerase II-specific • transcription regulator activity • DNA-binding transcription factor activity • nuclear estrogen receptor activity • ligand-modulated transcription factor activity • G protein-coupled estrogen receptor activity • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of signaling • regulation of cell cycle process • negative regulation of biological process • negative regulation of cell cycle • negative regulation of cell cycle process • negative regulation of cellular process • cell cycle • regulation of cell cycle • cell cycle process • regulation of biosynthetic process • regulation of lipid metabolic process • negative regulation of metabolic process • lipid biosynthetic process • primary metabolic process • negative regulation of lipid biosynthetic process • regulation of primary metabolic process • biosynthetic process • negative regulation of biosynthetic process • metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • negative regulation of lipid metabolic process • lipid metabolic process • positive regulation of organelle organization • regulation of cellular component organization • positive regulation of cellular component organization • apoptotic mitochondrial changes • regulation of release of cytochrome c from mitochondria • cellular component organization • positive regulation of release of cytochrome c from mitochondria • cellular component organization or biogenesis • mitochondrion organization • cell death • regulation of organelle organization • apoptotic signaling pathway • release of cytochrome c from mitochondria • organelle organization • regulation of mitochondrion organization • apoptotic process • programmed cell death • response to peptide hormone • cellular response to peptide hormone stimulus • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • positive regulation of protein localization to plasma membrane • protein localization • regulation of localization • cellular localization • regulation of protein localization • localization • cellular macromolecule localization • regulation of protein localization to membrane • positive regulation of protein localization to cell periphery • protein localization to cell periphery • protein localization to plasma membrane • positive regulation of protein localization to membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of protein localization to plasma membrane • hormone-mediated signaling pathway • response to steroid hormone • cellular response to steroid hormone stimulus • steroid hormone receptor signaling pathway • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • biological process involved in interspecies interaction between organisms • immune response • response to other organism • defense response • defense response to symbiont • response to external stimulus • response to biotic stimulus • immune system process • defense response to other organism • response to stress • innate immune response • response to external biotic stimulus • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cell communication • regulation of intracellular signal transduction • negative regulation of response to stimulus • regulation of MAPK cascade • negative regulation of signal transduction • negative regulation of ERK1 and ERK2 cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • negative regulation of MAPK cascade • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of ERBB signaling pathway • regulation of epidermal growth factor receptor signaling pathway • epidermal growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • positive regulation of epidermal growth factor receptor signaling pathway • regulation of ERBB signaling pathway • cell surface receptor signaling pathway • ERBB signaling pathway • regulation of leukocyte activation • cell activation • regulation of cell activation • leukocyte activation • negative regulation of cell activation • negative regulation of immune system process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • nervous system development • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • neurogenesis • positive regulation of cell differentiation • cell differentiation • positive regulation of neurogenesis • regulation of multicellular organismal development • positive regulation of cell development • positive regulation of multicellular organismal process • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • positive regulation of phosphate metabolic process • positive regulation of inositol trisphosphate biosynthetic process • regulation of small molecule metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • positive regulation of phosphorus metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cellular response to mineralocorticoid stimulus • response to mineralocorticoid • cellular response to corticosteroid stimulus • response to corticosteroid • fat cell differentiation • negative regulation of developmental process • negative regulation of fat cell differentiation • negative regulation of cell differentiation • regulation of fat cell differentiation • smooth muscle cell differentiation • positive regulation of smooth muscle cell differentiation • regulation of smooth muscle cell differentiation • muscle cell differentiation • regulation of cardiac vascular smooth muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • positive regulation of cardiocyte differentiation • blood vessel development • heart development • positive regulation of cardiac vascular smooth muscle cell differentiation • cardiac vascular smooth muscle cell differentiation • positive regulation of vascular associated smooth muscle cell differentiation • coronary vasculature development • regulation of vascular associated smooth muscle cell differentiation • positive regulation of muscle cell differentiation • vasculature development • cardiocyte differentiation • circulatory system development • regulation of muscle cell differentiation • regulation of cardiocyte differentiation • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • cellular response to glucose stimulus • intracellular glucose homeostasis • response to hexose • cellular response to carbohydrate stimulus • response to monosaccharide • response to carbohydrate • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • cellular component disassembly • membrane organization • nuclear fragmentation involved in apoptotic nuclear change • nuclear membrane organization • execution phase of apoptosis • nucleus organization • cellular component disassembly involved in execution phase of apoptosis • nuclear envelope organization • apoptotic nuclear changes • endomembrane system organization • positive regulation of smooth muscle contraction • positive regulation of uterine smooth muscle contraction • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • uterine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • regulation of uterine smooth muscle contraction • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • regulation of inflammatory response • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • intracellular receptor signaling pathway • nuclear receptor-mediated steroid hormone signaling pathway • nuclear receptor-mediated signaling pathway • extrinsic apoptotic signaling pathway • positive regulation of apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway • regulation of apoptotic signaling pathway • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • action potential • transmission of nerve impulse • neuronal action potential • regulation of membrane potential • positive regulation of cell population proliferation • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • response to peptide • cellular response to tumor necrosis factor • response to cytokine • cellular response to cytokine stimulus • response to tumor necrosis factor • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • chromosome organization • apoptotic chromosome condensation • chromosome condensation • positive regulation of endothelial cell apoptotic process • endothelial cell apoptotic process • regulation of endothelial cell apoptotic process • transport • modulation of chemical synaptic transmission • positive regulation of neurotransmitter secretion • positive regulation of secretion by cell • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • establishment of localization in cell • trans-synaptic signaling • positive regulation of neurotransmitter transport • neurotransmitter secretion • regulation of transport • secretion • regulation of neurotransmitter transport • export from cell • positive regulation of synaptic transmission • neurotransmitter transport • establishment of localization • regulation of secretion • chemical synaptic transmission • signal release from synapse • regulation of trans-synaptic signaling • positive regulation of transport • regulation of neurotransmitter secretion • anterograde trans-synaptic signaling • response to estradiol • cellular response to estradiol stimulus • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of protein modification process • protein metabolic process • positive regulation of protein phosphorylation • protein modification process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • macromolecule modification • regulation of phosphorylation • negative regulation of gene expression • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • positive regulation of hormone secretion • amide transport • positive regulation of peptide secretion • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • positive regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • presynapse • presynaptic active zone • organelle envelope • nuclear envelope • mitochondrial membrane • mitochondrion • mitochondrial envelope • presynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • dendrite • dendritic tree • Golgi membrane • endosome • intracellular vesicle • recycling endosome • cytoplasmic vesicle • dendritic shaft • perinuclear region of cytoplasm • dendritic spine • neuron projection membrane • dendrite membrane • cell leading edge • neuron spine • leading edge membrane • dendritic spine membrane • postsynapse • cell projection membrane • axon • dendritic spine head • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • cytoplasmic vesicle membrane • vesicle membrane • early endosome • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • postsynaptic density • postsynaptic specialization • asymmetric synapse • keratin filament • polymeric cytoskeletal fiber • intermediate filament cytoskeleton • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99527
Sequence	>8XOI_nogp_Chain_R H Q Q Y V I G L F L S C L Y T I F L F P I G F V G N I L I L V V N I S F R E K M T I P D L Y F I N L A V A D L I L V A D S L I E V F N L H E R Y Y D I A V L C T F M S L F L Q V N M Y S S V F F L T W M S F D R Y I A L A R A M R C S L F R T K H H A R L S C G L I W M A S V S A T L V P F T A V H L Q H D V R E V Q W L E V T L G F I V P F A I I G L C Y S L I V R V L V R A H R H R R R Q K A L R M I L A V V L V F F V C W L P E N V F I S V H L L Q H A H P L T G H I V N L A A F S N S C L N P L I Y S F L G E T F R D K L R L Y I E Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XOG	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-04-10	To be published
	8XOG (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		2.9	2024-04-10	To be published
	8XOJ	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2024-04-10	To be published
	8XOJ (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.1	2024-04-10	To be published
	8XOI	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	To be published
	8XOI (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	To be published
	8XOH	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	To be published
	8XOH (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	To be published
	8XOF	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOF (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-		2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y

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