Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L41 6.5375426
2A:A:N50 8.03499
3A:A:K53 6.3975429
4A:A:M60 5.3425429
5A:A:I207 5.57419
6A:A:F212 8.445429
7A:A:F219 7.936528
8A:A:H220 7.2875417
9A:A:M221 5.1875428
10A:A:F222 8.266517
11A:A:Q227 5.595419
12A:A:R228 8.7875409
13A:A:R231 8.072519
14A:A:K233 7.255619
15A:A:W234 7.36667619
16A:A:F238 8.175619
17A:A:I244 5.095418
18A:A:I245 4.925427
19A:A:F246 5.288519
20A:A:V247 4.4525427
21A:A:D249 8.3225498
22A:A:L270 6.19406
23A:A:F273 6.28519
24A:A:I276 4.514518
25A:A:W277 9.566516
26A:A:W281 7.98667615
27A:A:L282 5.985419
28A:A:I285 4.455417
29A:A:L289 4.57419
30A:A:F290 5.13714729
31A:A:L291 5.2075418
32A:A:K293 8.97499
33A:A:F312 6.0025108
34A:A:F315 9.6665106
35A:A:E330 6.4275403
36A:A:D331 6.184174
37A:A:V334 2.6625404
38A:A:F340 8.9785107
39A:A:F345 6.25518
40A:A:I348 4.39404
41A:A:S349 4.1325407
42A:A:R356 5.3402
43A:A:Y360 11.4725408
44A:A:F363 9.4725405
45A:A:T364 6.895429
46A:A:N371 5.65429
47A:A:R373 7.6325425
48A:A:R374 6.406524
49A:A:F376 6.00875828
50A:A:I383 3.83528
51A:A:L388 4.998577188
52A:A:E390 7.2675454
53A:A:Y391 13.4275454
54B:B:L4 3.6825404
55B:B:L14 4.155408
56B:B:I18 5.36754197
57B:B:R22 5.3854196
58B:B:R49 5.2125437
59B:B:L51 7.7625439
60B:B:H54 9.962539
61B:B:Y59 8.6425418
62B:B:M61 4.8875436
63B:B:W63 6.17714737
64B:B:L70 6.7225435
65B:B:V71 5.2125448
66B:B:S72 5.6725439
67B:B:Q75 8.7325419
68B:B:D76 9.175409
69B:B:K78 6.395408
70B:B:I81 4.178547
71B:B:W82 8.86739
72B:B:N88 7.645407
73B:B:K89 6.16833639
74B:B:H91 5.22445
75B:B:I93 5.4325447
76B:B:L95 5.704548
77B:B:W99 11.075619
78B:B:M101 5.98519
79B:B:Y105 4.76286746
80B:B:N110 6.5275414
81B:B:Y111 6.356514
82B:B:V112 4.53448
83B:B:C114 4.9775448
84B:B:L117 5.18419
85B:B:N119 4.585409
86B:B:C121 4.135418
87B:B:I123 4.134516
88B:B:Y124 5.19746
89B:B:E138 6.7075446
90B:B:L139 7.6125409
91B:B:H142 7.384519
92B:B:Y145 7.43618
93B:B:L146 4.54517
94B:B:C149 4.034518
95B:B:F151 5.26429719
96B:B:I157 6.3525417
97B:B:T159 5.326519
98B:B:D163 6.958519
99B:B:L168 3.5475406
100B:B:W169 9.66618
101B:B:F180 8.086567
102B:B:H183 6.83714769
103B:B:D186 7.61419
104B:B:L190 5.75405
105B:B:C204 3.5275417
106B:B:D205 7.0625469
107B:B:K209 8.38333666
108B:B:W211 9.21833668
109B:B:Q220 6.7925407
110B:B:H225 8.24143719
111B:B:D228 7.724519
112B:B:I232 5.8625418
113B:B:F235 6.8625116
114B:B:P236 6.0154117
115B:B:F241 9.062516
116B:B:T243 6.24418
117B:B:D247 6.58519
118B:B:T249 6.155416
119B:B:R251 8.74714718
120B:B:F253 6.81716
121B:B:D254 5.2925409
122B:B:R256 9.08409
123B:B:M262 5.8375484
124B:B:Y264 7.26685
125B:B:I269 4.96484
126B:B:R283 8.2554209
127B:B:L285 5.456506
128B:B:Y289 7.80333687
129B:B:C294 3.8975475
130B:B:N295 7.042586
131B:B:V307 3.6275403
132B:B:H311 7.272579
133B:B:R314 10.164518
134B:B:L318 5.4925406
135B:B:T329 6.125408
136B:B:W332 6.85719
137B:B:D333 8.435479
138B:B:L336 5.69537
139B:B:K337 7.9675476
140B:B:I338 5.02435
141B:B:W339 9.932579
142G:G:R27 6.94408
143G:G:Y40 11.0154116
144G:G:D48 6.3025219
145G:G:P49 3.4525407
146G:G:L50 5.01254219
147G:G:L51 4.3775406
148G:G:N59 6.1275439
149G:G:P60 7.1439
150G:G:F61 5.75857738
151R:R:Y65 4.311258125
152R:R:L69 3.7054127
153R:R:F70 6.1575407
154R:R:N77 6.22409
155R:R:V83 4.02407
156R:R:I93 6.0925456
157R:R:P94 8.024557
158R:R:D95 7.69458
159R:R:Y97 6.72167657
160R:R:D105 8.638509
161R:R:Y123 7.685408
162R:R:Q138 9.74155
163R:R:Y142 6.174157
164R:R:S143 5.444137
165R:R:F147 8.65138
166R:R:L148 5.784149
167R:R:R155 10.7525409
168R:R:Y156 6.364508
169R:R:M163 4.955426
170R:R:R169 8.448557
171R:R:T189 5.4425157
172R:R:E218 7.60254156
173R:R:F223 6.5585168
174R:R:P226 3.59409
175R:R:I230 5.4475408
176R:R:Y234 6.618509
177R:R:F268 6.93409
178R:R:W272 9.12409
179R:R:L273 6.43754165
180R:R:F278 6.24405
181R:R:H307 6.78403
182R:R:F314 5.98254127
183R:R:N320 9.60754149
184R:R:Y324 6.873336149
185R:R:F331 5.3065248
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:L55 12.781414.93YesNo096
2A:A:Y37 B:B:L55 13.99963.52NoNo036
3A:A:R42 A:A:Y37 14.46720.58NoNo093
4A:A:F222 A:A:R42 14.72644.28YesNo079
5B:B:C317 B:B:M61 15.36834.86NoYes076
6B:B:C317 B:B:S316 15.56593.44NoNo079
7B:B:S316 B:B:W332 15.7814.94NoYes099
8A:A:W281 B:B:W332 10.16693.75YesYes159
9A:A:N279 A:A:W281 32.74824.52NoYes085
10A:A:L282 A:A:N279 32.91718.24YesNo098
11A:A:I285 A:A:L282 80.98834.28YesYes179
12A:A:I285 A:A:T284 1003.04YesNo074
13A:A:R356 A:A:T284 99.93216.47YesNo024
14A:A:R356 A:A:R389 99.72664.26YesNo024
15A:A:R389 A:A:V394 99.65755.23NoNo048
16A:A:Q385 A:A:V394 21.78724.3NoNo058
17A:A:Q385 R:R:R254 21.64511.68NoNo056
18A:A:D381 R:R:R254 49.771410.72NoNo086
19A:A:D381 R:R:R248 13.67177.15NoNo084
20A:A:N377 R:R:R248 11.36754.82NoNo044
21A:A:L388 A:A:V394 77.90544.47YesNo088
22A:A:L388 R:R:R254 28.58793.64YesNo086
23A:A:D381 A:A:Y360 35.925112.64NoYes088
24A:A:D378 A:A:Y360 34.464511.49NoYes078
25A:A:D378 A:A:I288 12.883712.59NoNo079
26A:A:F290 A:A:I288 12.14593.77YesNo099
27A:A:D378 A:A:H362 21.220311.35NoNo079
28A:A:F290 A:A:H362 12.14526.79YesNo099
29A:A:F222 A:A:F238 16.40654.29YesYes179
30A:A:F238 A:A:L44 11.173317.05YesNo099
31A:A:R231 A:A:W234 25.065211YesYes199
32B:B:W332 B:B:Y59 14.82924.82YesYes198
33B:B:M101 B:B:Y59 13.81048.38YesYes198
34B:B:M101 B:B:Y145 14.77987.18YesYes198
35A:A:W234 B:B:Y145 84.45097.72YesYes198
36A:A:I235 A:A:L282 55.275.71NoYes199
37A:A:I276 A:A:R231 12.91748.77YesYes189
38A:A:F290 A:A:T364 11.46386.49YesYes299
39A:A:N292 A:A:T364 16.0095.85NoYes099
40A:A:K293 A:A:N292 11.442512.59YesNo099
41B:B:G162 B:B:Y145 32.811110.14NoYes198
42B:B:G162 B:B:S161 33.8063.71NoNo199
43A:A:K233 B:B:Y145 65.90783.58YesYes198
44A:A:D272 A:A:R231 12.664610.72NoYes189
45A:A:K233 B:B:D228 64.612511.06YesYes199
46A:A:I244 A:A:V287 18.74763.07YesNo186
47A:A:F246 A:A:I276 13.00523.77YesYes198
48A:A:D272 A:A:F246 12.43458.36NoYes189
49A:A:F273 A:A:V287 14.21075.24YesNo196
50A:A:F246 A:A:F273 11.83946.43YesYes199
51A:A:F246 A:A:L289 13.51164.87YesYes199
52A:A:F273 A:A:F345 13.91186.43YesYes198
53A:A:F345 A:A:L270 13.06198.53YesYes086
54A:A:E344 A:A:L270 19.17936.63NoYes056
55A:A:E344 A:A:F340 10.800513.99NoYes1057
56A:A:L388 A:A:L393 62.56136.92YesNo088
57A:A:L393 R:R:R155 56.688512.15NoYes089
58R:R:R155 R:R:Y324 43.78056.17YesYes099
59R:R:N320 R:R:Y324 25.73835.81YesYes1499
60R:R:D105 R:R:N320 15.832812.12YesYes099
61R:R:D105 R:R:N77 11.73666.73YesYes099
62B:B:D228 B:B:S227 66.28864.42YesNo196
63B:B:S227 B:B:S245 22.7743.26NoNo169
64B:B:H225 B:B:S245 22.60169.76YesNo199
65B:B:F253 B:B:H225 38.53573.39YesYes169
66B:B:F222 B:B:F253 49.787112.86NoYes186
67B:B:F222 B:B:Q220 49.76024.68NoYes087
68B:B:D258 B:B:Q220 43.180113.05NoYes077
69B:B:D258 B:B:R22 25.40765.96NoYes076
70B:B:I18 B:B:R22 16.62546.26YesYes1976
71B:B:I18 G:G:A23 32.46063.25YesNo078
72B:B:L14 G:G:A23 30.14981.58YesNo088
73B:B:E10 B:B:L14 15.10035.3NoYes088
74B:B:E10 B:B:Q6 11.62011.27NoNo081
75B:B:D247 B:B:S227 43.37734.42YesNo196
76B:B:D247 B:B:H225 22.60298.82YesYes199
77B:B:D247 B:B:R251 20.02013.57YesYes198
78B:B:F253 B:B:R251 19.36615.34YesYes168
79B:B:D258 G:G:R27 17.430914.29NoYes078
80B:B:I18 G:G:R27 15.90453.76YesYes078
81B:B:L14 G:G:L19 11.62016.92YesNo089
82B:B:K15 G:G:L19 10.45954.23NoNo069
83B:B:Q259 B:B:R22 10.5854.67NoYes066
84B:B:R314 B:B:T274 31.04789.06YesNo088
85B:B:S275 B:B:T274 30.84773.2NoNo088
86B:B:L318 B:B:S275 30.65357.51YesNo068
87B:B:L286 B:B:L318 22.04885.54NoYes076
88B:B:H142 B:B:S161 32.5315.34YesNo199
89B:B:H142 B:B:L146 12.57673.86YesYes197
90B:B:C149 B:B:L146 11.9513.17YesYes187
91B:B:C149 B:B:T102 26.04955.07YesNo088
92B:B:C148 B:B:T102 25.66333.38NoNo068
93B:B:H142 B:B:T159 12.3415.48YesYes199
94B:B:C149 B:B:T159 12.06073.38YesYes189
95B:B:C148 B:B:L190 24.67746.35NoYes065
96B:B:L285 B:B:Y264 10.3597.03YesYes065
97B:B:G306 B:B:V296 16.74341.84NoNo045
98B:B:G306 B:B:V307 16.56191.84NoYes043
99B:B:N295 B:B:W297 11.58214.52YesNo868
100B:B:W297 B:B:Y264 11.606415.43NoYes885
101R:R:L148 R:R:Y324 14.59055.86YesYes1499
102R:R:F268 R:R:L148 15.01554.87YesYes099
103R:R:F268 R:R:W272 10.624511.02YesYes099
104R:R:N316 R:R:N320 10.872812.26NoYes099
105R:R:N316 R:R:W272 10.498918.08NoYes099
106R:R:M141 R:R:W272 14.00623.49NoYes079
107A:A:I244 A:A:I285 19.14645.89YesYes187
108A:A:I244 A:A:L44 10.90935.71YesNo089
109A:A:I235 A:A:W234 54.40014.7NoYes199
110B:B:L286 B:B:V296 19.01717.45NoNo075
111A:A:W281 B:B:R314 22.6919YesYes158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XOH
Class A
SubFamily Steroid
Type Estrogen
SubType GPER1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-04-10
D.O.I. To be published
Net Summary
Imin 3.04
Number of Linked Nodes 849
Number of Links 1065
Number of Hubs 185
Number of Links mediated by Hubs 666
Number of Communities 26
Number of Nodes involved in Communities 260
Number of Links involved in Communities 390
Path Summary
Number Of Nodes in MetaPath 112
Number Of Links MetaPath 111
Number of Shortest Paths 1301326
Length Of Smallest Path 3
Average Path Length 24.0167
Length of Longest Path 46
Minimum Path Strength 1.155
Average Path Strength 6.67368
Maximum Path Strength 20.765
Minimum Path Correlation 0.7
Average Path Correlation 0.978828
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 49.1145
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.3837
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8XOH_Chain_A
EDKAAVERS KMIEKQLQK DKQVYRRTL RLLLLGADN SGKSTIVKQ 
MRITSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ CFNDVTAII 
FVVDSSDNR LQEALNDFD SIWNNRWLR TISVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRKEFV 
DISTASGDG RHICYPHFT CAVDTENAR RIFNDCKDI ILQMNLREY 
NLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8XOH_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8XOH_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99527
Sequence
>8XOH_Chain_R
EHQQYVIGL FLSCLYTIF LFPIGFVGN ILILVVNIS FREKMTIPD 
LYFINLAVA DLILVADSL IEVFNLHER YYDIAVLCT FMSLFLQVN 
MYSSVFFLT WMSFDRYIA LARAMRCSL FRTKHHARL SCGLIWMAS 
VSATLVPFT AVHLQHDVR EVQWLEVTL GFIVPFAII GLCYSLIVR 
VLVRAHRHR RRQKALRMI LAVVLVFFV CWLPENVFI SVHLLQHAH 
PLTGHIVNL AAFSNSCLN PLIYSFLGE TFRDKLRLY IEQK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XOGASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.92024-04-10To be published
8XOHASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22024-04-10To be published
8XOIASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22024-04-10To be published
8XOJASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.12024-04-10To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XOH.zip



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