Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N50 3.975409
2A:A:V214 5.12254116
3A:A:F219 7.0056118
4A:A:H220 9.5075417
5A:A:F222 9.86417
6A:A:R228 7.165409
7A:A:K233 5.784229
8A:A:W234 7.606509
9A:A:F238 8.8775419
10A:A:D249 6.9275408
11A:A:L270 4.9175406
12A:A:F273 5.522539
13A:A:I276 4.04408
14A:A:W277 8.536506
15A:A:W281 6.33167615
16A:A:I285 4.0175407
17A:A:F290 5.088336209
18A:A:Q294 7.93536
19A:A:F315 10.988506
20A:A:E330 8.575403
21A:A:D331 8.525404
22A:A:V334 4.205404
23A:A:K338 10.0325435
24A:A:F340 8.8845237
25A:A:F345 6.79438
26A:A:Y360 8.0645248
27A:A:F363 10.59435
28A:A:R373 6.834115
29A:A:F376 6.9265118
30A:A:Y391 9.272524
31B:B:L7 3.93408
32B:B:L14 5.185408
33B:B:V40 6.095483
34B:B:L51 7.83409
35B:B:H54 9.804579
36B:B:Y59 6.395618
37B:B:W63 7.638577
38B:B:L70 6.435475
39B:B:Q75 6.6475419
40B:B:D76 6.8845199
41B:B:I81 4.7525447
42B:B:W82 9.20667679
43B:B:D83 7.8954188
44B:B:N88 7.28254187
45B:B:K89 6.672579
46B:B:H91 4.9575445
47B:B:I93 5.815447
48B:B:L95 5.662548
49B:B:W99 10.054519
50B:B:Y105 4.684546
51B:B:N110 6.55254124
52B:B:Y111 5.4025124
53B:B:I123 3.954126
54B:B:Y124 5.17571746
55B:B:H142 7.9585109
56B:B:Y145 7.346218
57B:B:F151 3.98333609
58B:B:L152 5.21254143
59B:B:T159 5.2725109
60B:B:D163 8.854109
61B:B:C166 4.0475468
62B:B:L168 3.87754146
63B:B:W169 10.1625108
64B:B:D170 5.215409
65B:B:F180 7.582567
66B:B:H183 8.116509
67B:B:F199 8.442569
68B:B:V200 6.585456
69B:B:K209 9.12566
70B:B:L210 5.56405
71B:B:W211 9.484568
72B:B:F222 7.72458
73B:B:H225 10.36409
74B:B:D228 8.53254229
75B:B:F234 5.755405
76B:B:F235 7.0465156
77B:B:P236 6.37754157
78B:B:F241 6.39333656
79B:B:R251 9.122558
80B:B:F253 7.395656
81B:B:D254 7.59409
82B:B:R256 12.34409
83B:B:D258 10.3525457
84B:B:M262 6.6325404
85B:B:Y264 7.652505
86B:B:R283 7.852589
87B:B:L285 5.975406
88B:B:Y289 6.73717
89B:B:D290 7.205416
90B:B:D298 10.235489
91B:B:L300 6.1825486
92B:B:H311 8.924139
93B:B:R314 10.114518
94B:B:T329 6.264138
95B:B:W332 8.25619
96B:B:L336 4.3475407
97B:B:K337 6.55254136
98B:B:W339 7.835139
99G:G:A23 3.1125408
100G:G:R27 6.2975408
101G:G:Y40 8.19754156
102G:G:D48 6.6685269
103G:G:L50 5.4054269
104G:G:L51 3.03406
105G:G:P60 5.9975499
106G:G:F61 5.24429798
107R:R:Y65 5.04507
108R:R:F70 6.9775407
109R:R:N77 7.9575409
110R:R:F87 6.3875405
111R:R:I93 4.5275406
112R:R:P94 6.668528
113R:R:D95 8.0025427
114R:R:D105 6.626509
115R:R:F117 5.5354303
116R:R:L135 5.8025406
117R:R:Y142 4.94507
118R:R:F147 11.02254168
119R:R:W150 7.7575407
120R:R:R155 8.4625409
121R:R:Y156 5.16408
122R:R:R169 5.936527
123R:R:W216 6.9025334
124R:R:F223 5.5575409
125R:R:P226 3.585409
126R:R:I230 4.2925408
127R:R:Y234 7.6275408
128R:R:R248 5.71754242
129R:R:R253 7.48405
130R:R:R254 7.35506
131R:R:K256 6.3525407
132R:R:W272 7.892509
133R:R:L273 4405
134R:R:F278 6.3754175
135R:R:T305 3.97254175
136R:R:F314 7.1925406
137R:R:Y324 6.598509
138R:R:F331 5.90754259
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:L69 11.75464.07YesNo085
2B:B:I81 B:B:L69 11.10674.28YesNo075
3B:B:H91 B:B:I81 10.13143.98YesYes457
4B:B:D76 B:B:S74 22.14298.83YesNo099
5B:B:H54 B:B:S74 21.992311.16YesNo099
6B:B:H54 B:B:W82 15.77114.23YesYes799
7B:B:D76 B:B:L55 10012.21YesNo096
8A:A:K34 B:B:L55 99.93417.05NoNo056
9A:A:K34 A:A:R38 99.80184.95NoNo054
10A:A:Y37 B:B:D76 94.84664.6NoYes1939
11A:A:R42 A:A:Y37 94.98715.43NoNo093
12A:A:R38 R:R:T170 99.73543.88NoNo046
13A:A:F222 A:A:R42 95.01934.28YesNo079
14A:A:I358 A:A:Y360 17.85378.46NoYes048
15A:A:I358 A:A:Q385 17.99494.12NoNo045
16A:A:Q385 R:R:R253 23.44425.84NoYes055
17A:A:V394 R:R:R253 24.54387.85NoYes085
18A:A:L388 A:A:V394 24.81948.94NoNo088
19A:A:L388 A:A:L393 25.09494.15NoNo088
20A:A:L393 R:R:R155 25.45456.07NoYes089
21A:A:Y391 R:R:R155 54.751913.38YesYes049
22A:A:Y391 R:R:R169 87.78475.14YesYes247
23R:R:F168 R:R:R169 99.26674.28NoYes017
24R:R:F168 R:R:H173 99.40143.39NoNo013
25R:R:H173 R:R:T170 99.66910.95NoNo036
26A:A:D378 A:A:Y360 13.249810.34NoYes078
27A:A:F222 B:B:W99 95.436219.04YesYes179
28A:A:F238 B:B:W99 26.433611.02YesYes199
29A:A:F238 A:A:L44 10.908315.83YesNo099
30A:A:L44 A:A:L46 10.57311.07NoNo098
31A:A:I276 A:A:L46 10.48934.28YesNo088
32A:A:I276 A:A:R231 14.62535.01YesNo089
33A:A:R231 A:A:W234 14.72089NoYes099
34A:A:F238 A:A:W234 15.51775.01YesYes099
35B:B:Q75 B:B:W99 69.0210.95YesYes199
36B:B:Q75 B:B:Y59 48.22765.64YesYes198
37A:A:Q236 B:B:Y59 25.82487.89NoYes188
38B:B:K57 B:B:Q75 20.7585.42NoYes099
39B:B:K57 B:B:W332 20.63169.28NoYes099
40A:A:W281 B:B:W332 23.10273.75YesYes159
41B:B:W332 B:B:Y59 26.04599.65YesYes198
42A:A:Q236 A:A:W281 12.86154.38NoYes185
43B:B:R314 B:B:W332 23.138514.99YesYes189
44A:A:Q236 B:B:R314 12.89867.01NoYes188
45A:A:F246 A:A:I276 24.74573.77NoYes098
46A:A:F246 A:A:F273 19.66165.36NoYes099
47A:A:E344 A:A:L270 11.01473.98NoYes056
48A:A:W281 B:B:D290 37.6674.47YesYes156
49B:B:D290 B:B:R314 35.281513.1YesYes168
50A:A:Y391 R:R:M151 31.91133.59YesNo049
51R:R:M151 R:R:Y324 32.25223.59NoYes099
52R:R:L148 R:R:Y324 66.16197.03NoYes089
53R:R:L101 R:R:L148 15.99336.92NoNo098
54R:R:D105 R:R:L101 15.71728.14YesNo099
55R:R:D105 R:R:N77 12.02896.73YesYes099
56R:R:R155 R:R:Y324 34.92126.17YesYes099
57R:R:L148 R:R:N320 49.92435.49NoNo089
58R:R:D105 R:R:N320 15.93539.42YesNo099
59B:B:C271 B:B:D290 72.086.22NoYes156
60B:B:C271 B:B:Y289 65.16854.03NoYes157
61B:B:W297 B:B:Y289 62.6425.79NoYes087
62B:B:W297 B:B:Y264 61.325410.61NoYes085
63B:B:L252 B:B:Y264 46.08087.03NoYes075
64B:B:L252 B:B:L261 45.61744.15NoNo075
65B:B:L261 G:G:V30 41.48194.47NoNo058
66B:B:Q259 G:G:V30 41.01715.73NoNo068
67B:B:Q259 B:B:R22 40.0875.84NoNo066
68B:B:I18 B:B:R22 12.8526.26NoNo076
69B:B:I18 G:G:A23 12.3783.25NoYes078
70B:B:L14 G:G:A23 10.9551.58YesYes088
71B:B:D258 B:B:R22 27.002714.29YesNo076
72B:B:M101 B:B:Y59 18.02495.99NoYes098
73B:B:G116 B:B:M101 14.88383.49NoNo099
74B:B:G115 B:B:G116 14.73252.11NoNo099
75B:B:G115 B:B:L146 14.58113.42NoNo097
76B:B:I157 B:B:W169 11.45493.52NoYes078
77B:B:D258 B:B:F222 16.12233.58YesYes578
78R:R:N316 R:R:N320 34.176512.26NoNo099
79R:R:N316 R:R:W272 33.362715.82NoYes099
80R:R:F268 R:R:W272 15.717511.02NoYes099
81R:R:F227 R:R:F268 14.02135.36NoNo069
82R:R:D105 R:R:S317 18.01224.42YesNo098
83R:R:L108 R:R:S317 17.46049.01NoNo078
84R:R:F314 R:R:L108 17.16373.65YesNo067
85R:R:F314 R:R:S112 15.453513.21YesNo068
86R:R:S112 R:R:Y65 14.31266.36NoYes087
87R:R:V145 R:R:W272 13.71433.68NoYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XOJ
Class A
SubFamily Orphan
Type Orphan
SubType GPR30
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.1
Date 2024-04-10
D.O.I. To be published
Net Summary
Imin 3.39
Number of Linked Nodes 843
Number of Links 975
Number of Hubs 138
Number of Links mediated by Hubs 528
Number of Communities 33
Number of Nodes involved in Communities 196
Number of Links involved in Communities 250
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 1888397
Length Of Smallest Path 3
Average Path Length 32.0535
Length of Longest Path 56
Minimum Path Strength 1.31
Average Path Strength 7.12962
Maximum Path Strength 18.3
Minimum Path Correlation 0.71
Average Path Correlation 0.984591
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 41.3039
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.4556
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • D1 dopamine receptor binding   • molecular function activator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase activator activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • steroid hormone binding   • steroid binding   • lipid binding   • hormone binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • chromatin binding   • nuclear receptor activity   • nuclear steroid receptor activity   • DNA-binding transcription factor activity, RNA polymerase II-specific   • transcription regulator activity   • DNA-binding transcription factor activity   • nuclear estrogen receptor activity   • ligand-modulated transcription factor activity   • G protein-coupled estrogen receptor activity   • positive regulation of cell communication   • regulation of signaling   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • positive regulation of G protein-coupled receptor signaling pathway   • positive regulation of response to stimulus   • regulation of response to stimulus   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cellular process   • positive regulation of signaling   • regulation of cell cycle process   • negative regulation of biological process   • negative regulation of cell cycle   • negative regulation of cell cycle process   • negative regulation of cellular process   • cell cycle   • regulation of cell cycle   • cell cycle process   • regulation of biosynthetic process   • regulation of lipid metabolic process   • negative regulation of metabolic process   • lipid biosynthetic process   • primary metabolic process   • negative regulation of lipid biosynthetic process   • regulation of primary metabolic process   • biosynthetic process   • negative regulation of biosynthetic process   • metabolic process   • regulation of lipid biosynthetic process   • regulation of metabolic process   • negative regulation of lipid metabolic process   • lipid metabolic process   • positive regulation of organelle organization   • regulation of cellular component organization   • positive regulation of cellular component organization   • apoptotic mitochondrial changes   • regulation of release of cytochrome c from mitochondria   • cellular component organization   • positive regulation of release of cytochrome c from mitochondria   • cellular component organization or biogenesis   • mitochondrion organization   • cell death   • regulation of organelle organization   • apoptotic signaling pathway   • release of cytochrome c from mitochondria   • organelle organization   • regulation of mitochondrion organization   • apoptotic process   • programmed cell death   • response to peptide hormone   • cellular response to peptide hormone stimulus   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • positive regulation of protein localization to plasma membrane   • protein localization   • regulation of localization   • cellular localization   • regulation of protein localization   • localization   • cellular macromolecule localization   • regulation of protein localization to membrane   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • protein localization to plasma membrane   • positive regulation of protein localization to membrane   • regulation of protein localization to cell periphery   • localization within membrane   • protein localization to membrane   • regulation of cellular localization   • macromolecule localization   • positive regulation of protein localization   • regulation of protein localization to plasma membrane   • hormone-mediated signaling pathway   • response to steroid hormone   • cellular response to steroid hormone stimulus   • steroid hormone receptor signaling pathway   • positive regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • positive regulation of apoptotic process   • biological process involved in interspecies interaction between organisms   • immune response   • response to other organism   • defense response   • defense response to symbiont   • response to external stimulus   • response to biotic stimulus   • immune system process   • defense response to other organism   • response to stress   • innate immune response   • response to external biotic stimulus   • negative regulation of signaling   • negative regulation of intracellular signal transduction   • negative regulation of cell communication   • regulation of intracellular signal transduction   • negative regulation of response to stimulus   • regulation of MAPK cascade   • negative regulation of signal transduction   • negative regulation of ERK1 and ERK2 cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • negative regulation of MAPK cascade   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • regulation of cytosolic calcium ion concentration   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • cell surface receptor protein tyrosine kinase signaling pathway   • positive regulation of ERBB signaling pathway   • regulation of epidermal growth factor receptor signaling pathway   • epidermal growth factor receptor signaling pathway   • enzyme-linked receptor protein signaling pathway   • positive regulation of epidermal growth factor receptor signaling pathway   • regulation of ERBB signaling pathway   • cell surface receptor signaling pathway   • ERBB signaling pathway   • regulation of leukocyte activation   • cell activation   • regulation of cell activation   • leukocyte activation   • negative regulation of cell activation   • negative regulation of immune system process   • regulation of immune system process   • regulation of multicellular organismal process   • negative regulation of multicellular organismal process   • negative regulation of leukocyte activation   • nervous system development   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of nervous system development   • regulation of developmental process   • cellular developmental process   • cell development   • regulation of cell differentiation   • regulation of neurogenesis   • regulation of cell development   • regulation of nervous system development   • positive regulation of developmental process   • neurogenesis   • positive regulation of cell differentiation   • cell differentiation   • positive regulation of neurogenesis   • regulation of multicellular organismal development   • positive regulation of cell development   • positive regulation of multicellular organismal process   • regulation of inositol phosphate biosynthetic process   • regulation of inositol trisphosphate biosynthetic process   • alcohol metabolic process   • inositol phosphate metabolic process   • positive regulation of phosphate metabolic process   • positive regulation of inositol trisphosphate biosynthetic process   • regulation of small molecule metabolic process   • regulation of phosphate metabolic process   • phosphate-containing compound metabolic process   • polyol biosynthetic process   • inositol trisphosphate metabolic process   • small molecule metabolic process   • phosphorus metabolic process   • regulation of carbohydrate metabolic process   • carbohydrate metabolic process   • polyol metabolic process   • regulation of alcohol biosynthetic process   • positive regulation of phosphorus metabolic process   • small molecule biosynthetic process   • inositol trisphosphate biosynthetic process   • carbohydrate biosynthetic process   • positive regulation of inositol phosphate biosynthetic process   • organophosphate metabolic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • regulation of phosphorus metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of carbohydrate metabolic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of DNA-templated transcription   • RNA metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of nucleobase-containing compound metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • regulation of vascular associated smooth muscle cell proliferation   • negative regulation of cell population proliferation   • regulation of smooth muscle cell proliferation   • negative regulation of vascular associated smooth muscle cell proliferation   • smooth muscle cell proliferation   • negative regulation of smooth muscle cell proliferation   • regulation of cell population proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • cellular response to mineralocorticoid stimulus   • response to mineralocorticoid   • cellular response to corticosteroid stimulus   • response to corticosteroid   • fat cell differentiation   • negative regulation of developmental process   • negative regulation of fat cell differentiation   • negative regulation of cell differentiation   • regulation of fat cell differentiation   • smooth muscle cell differentiation   • positive regulation of smooth muscle cell differentiation   • regulation of smooth muscle cell differentiation   • muscle cell differentiation   • regulation of cardiac vascular smooth muscle cell differentiation   • muscle structure development   • vascular associated smooth muscle cell differentiation   • positive regulation of cardiocyte differentiation   • blood vessel development   • heart development   • positive regulation of cardiac vascular smooth muscle cell differentiation   • cardiac vascular smooth muscle cell differentiation   • positive regulation of vascular associated smooth muscle cell differentiation   • coronary vasculature development   • regulation of vascular associated smooth muscle cell differentiation   • positive regulation of muscle cell differentiation   • vasculature development   • cardiocyte differentiation   • circulatory system development   • regulation of muscle cell differentiation   • regulation of cardiocyte differentiation   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • positive regulation of ERK1 and ERK2 cascade   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • cellular component disassembly   • membrane organization   • nuclear fragmentation involved in apoptotic nuclear change   • nuclear membrane organization   • execution phase of apoptosis   • nucleus organization   • cellular component disassembly involved in execution phase of apoptosis   • nuclear envelope organization   • apoptotic nuclear changes   • endomembrane system organization   • positive regulation of smooth muscle contraction   • positive regulation of uterine smooth muscle contraction   • regulation of system process   • muscle contraction   • muscle system process   • regulation of muscle system process   • uterine smooth muscle contraction   • smooth muscle contraction   • regulation of smooth muscle contraction   • regulation of muscle contraction   • positive regulation of muscle contraction   • regulation of uterine smooth muscle contraction   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • regulation of inflammatory response   • negative regulation of response to external stimulus   • regulation of response to stress   • negative regulation of defense response   • inflammatory response   • intracellular receptor signaling pathway   • nuclear receptor-mediated steroid hormone signaling pathway   • nuclear receptor-mediated signaling pathway   • extrinsic apoptotic signaling pathway   • positive regulation of apoptotic signaling pathway   • positive regulation of extrinsic apoptotic signaling pathway   • regulation of extrinsic apoptotic signaling pathway   • regulation of apoptotic signaling pathway   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • action potential   • transmission of nerve impulse   • neuronal action potential   • regulation of membrane potential   • positive regulation of cell population proliferation   • regulation of tube diameter   • regulation of tube size   • circulatory system process   • vascular process in circulatory system   • blood vessel diameter maintenance   • vasodilation   • blood circulation   • regulation of anatomical structure size   • response to peptide   • cellular response to tumor necrosis factor   • response to cytokine   • cellular response to cytokine stimulus   • response to tumor necrosis factor   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • chromosome organization   • apoptotic chromosome condensation   • chromosome condensation   • positive regulation of endothelial cell apoptotic process   • endothelial cell apoptotic process   • regulation of endothelial cell apoptotic process   • transport   • modulation of chemical synaptic transmission   • positive regulation of neurotransmitter secretion   • positive regulation of secretion by cell   • regulation of secretion by cell   • secretion by cell   • positive regulation of secretion   • signal release   • establishment of localization in cell   • trans-synaptic signaling   • positive regulation of neurotransmitter transport   • neurotransmitter secretion   • regulation of transport   • secretion   • regulation of neurotransmitter transport   • export from cell   • positive regulation of synaptic transmission   • neurotransmitter transport   • establishment of localization   • regulation of secretion   • chemical synaptic transmission   • signal release from synapse   • regulation of trans-synaptic signaling   • positive regulation of transport   • regulation of neurotransmitter secretion   • anterograde trans-synaptic signaling   • response to estradiol   • cellular response to estradiol stimulus   • regulation of calcium ion transport   • positive regulation of cation transmembrane transport   • positive regulation of calcium ion transport   • calcium ion transport   • positive regulation of monoatomic ion transport   • positive regulation of monoatomic ion transmembrane transport   • monoatomic cation transport   • regulation of release of sequestered calcium ion into cytosol   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • inorganic cation transmembrane transport   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • regulation of transmembrane transport   • monoatomic ion transmembrane transport   • regulation of monoatomic ion transmembrane transport   • negative regulation of sequestering of calcium ion   • metal ion transport   • maintenance of location in cell   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • positive regulation of calcium ion transmembrane transport   • positive regulation of transmembrane transport   • monoatomic ion transport   • positive regulation of release of sequestered calcium ion into cytosol   • regulation of metal ion transport   • regulation of sequestering of calcium ion   • calcium ion transmembrane import into cytosol   • sequestering of calcium ion   • regulation of monoatomic cation transmembrane transport   • calcium ion transmembrane transport   • positive regulation of phosphorylation   • regulation of protein modification process   • regulation of protein phosphorylation   • positive regulation of protein metabolic process   • positive regulation of protein modification process   • protein metabolic process   • positive regulation of protein phosphorylation   • protein modification process   • protein phosphorylation   • phosphorylation   • regulation of protein metabolic process   • macromolecule modification   • regulation of phosphorylation   • negative regulation of gene expression   • negative regulation of macromolecule biosynthetic process   • negative regulation of macromolecule metabolic process   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of hormone secretion   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • positive regulation of hormone secretion   • amide transport   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • insulin secretion   • presynapse   • presynaptic active zone   • organelle envelope   • nuclear envelope   • mitochondrial membrane   • mitochondrion   • mitochondrial envelope   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • Golgi membrane   • endosome   • intracellular vesicle   • recycling endosome   • cytoplasmic vesicle   • dendritic shaft   • perinuclear region of cytoplasm   • dendritic spine   • neuron projection membrane   • dendrite membrane   • cell leading edge   • neuron spine   • leading edge membrane   • dendritic spine membrane   • postsynapse   • cell projection membrane   • axon   • dendritic spine head   • endoplasmic reticulum subcompartment   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • endoplasmic reticulum membrane   • cytoplasmic vesicle membrane   • vesicle membrane   • early endosome   • neuron to neuron synapse   • hippocampal mossy fiber to CA3 synapse   • postsynaptic density   • postsynaptic specialization   • asymmetric synapse   • keratin filament   • polymeric cytoskeletal fiber   • intermediate filament cytoskeleton   • intermediate filament   • supramolecular fiber   • supramolecular polymer   • supramolecular complex   • axon terminus   • distal axon   • neuron projection terminus
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8XOJ_Chain_A
EDKAAVERS KMIEKQLQK DKQVYRRTL RLLLLGADN SGKSTIVKQ 
MRITSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ CFNDVTAII 
FVVDSSDNR LQEALNDFD SIWNNRWLR TISVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRKEFV 
DISTASGDG RHICYPHFT CAVDTENAR RIFNDCKDI ILQMNLREY 
NLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8XOJ_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8XOJ_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99527
Sequence
>8XOJ_Chain_R
SEHQQYVIG LFLSCLYTI FLFPIGFVG NILILVVNI SFREKMTIP 
DLYFINLAV ADLILVADS LIEVFNLHE RYYDIAVLC TFMSLFLQV 
NMYSSVFFL TWMSFDRYI ALARAMRCS LFRTKHHAR LSCGLIWMA 
SVSATLVPF TAVHLQHDV REVQWLEVT LGFIVPFAI IGLCYSLIV 
RVLVRAHRH RRRQKALRM ILAVVLVFF VCWLPENVF ISVHLLQHA 
HPLTGHIVN LAAFSNSCL NPLIYSFLG ETFRDKLRL YIEQK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XOGAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92024-04-10To be published
8XOG (No Gprot) AOrphanOrphanGPR30Homo sapiens--2.92024-04-10To be published
8XOJAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.12024-04-10To be published
8XOJ (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.12024-04-10To be published
8XOIAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10To be published
8XOI (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10To be published
8XOHAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10To be published
8XOH (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10To be published
8XOFAOrphanOrphanGPR30Homo sapiensLys05-chim(NtGi1-Gs-CtGq)/β1/γ22.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOF (No Gprot) AOrphanOrphanGPR30Homo sapiensLys05-2.62024-04-10doi.org/10.1038/s41422-024-00963-y




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