Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N50 3.975409
2A:A:V214 5.12254136
3A:A:F219 7.0056138
4A:A:H220 9.5075477
5A:A:F222 9.86477
6A:A:R228 7.165409
7A:A:K233 5.4545159
8A:A:W234 7.606509
9A:A:F238 8.8775479
10A:A:V248 4.9575417
11A:A:D249 6.9275408
12A:A:L270 4.9175406
13A:A:F273 5.522519
14A:A:I276 4.04408
15A:A:W277 9.7365246
16A:A:W281 6.331676115
17A:A:I285 4.0175407
18A:A:F290 5.088336229
19A:A:Q294 8.915416
20A:A:F315 10.988506
21A:A:E330 8.575403
22A:A:D331 8.525404
23A:A:V334 4.205404
24A:A:K338 10.0325415
25A:A:F340 8.8845257
26A:A:F345 6.162518
27A:A:Y360 8.0645268
28A:A:F363 10.285415
29A:A:R373 6.834135
30A:A:F376 6.9265138
31A:A:Y391 9.272524
32B:B:L7 3.93408
33B:B:L14 5.185408
34B:B:V40 6.095483
35B:B:L51 7.83409
36B:B:H54 9.804569
37B:B:W63 7.638567
38B:B:L70 6.435465
39B:B:D76 6.8845219
40B:B:I81 4.7525457
41B:B:W82 9.20667669
42B:B:D83 7.8954208
43B:B:N88 7.28254207
44B:B:K89 6.672569
45B:B:H91 4.9575455
46B:B:I93 5.815457
47B:B:L95 5.662558
48B:B:W99 10.054579
49B:B:N110 6.55254144
50B:B:Y111 5.4025144
51B:B:I123 3.954146
52B:B:Y124 5.17571756
53B:B:H142 7.9585109
54B:B:Y145 7.346238
55B:B:F151 3.98333609
56B:B:L152 5.21254163
57B:B:T159 5.2725109
58B:B:D163 8.854109
59B:B:C166 4.0475448
60B:B:L168 3.87754166
61B:B:W169 10.1625108
62B:B:D170 5.215409
63B:B:F180 7.582547
64B:B:H183 8.116509
65B:B:F199 8.442549
66B:B:V200 6.585436
67B:B:K209 9.12546
68B:B:L210 5.56405
69B:B:W211 9.484548
70B:B:F222 7.72438
71B:B:H225 10.36409
72B:B:D228 8.53254159
73B:B:F234 5.755405
74B:B:F235 7.0465176
75B:B:P236 6.37754177
76B:B:F241 6.39333636
77B:B:R251 9.122538
78B:B:F253 7.395636
79B:B:D254 7.59409
80B:B:R256 12.34409
81B:B:D258 10.3525437
82B:B:M262 6.6325404
83B:B:Y264 7.652505
84B:B:R283 7.852589
85B:B:L285 5.975406
86B:B:Y289 6.737117
87B:B:D290 7.2054116
88B:B:D298 10.235489
89B:B:L300 6.1825486
90B:B:H311 9.1525129
91B:B:R314 10.1145118
92B:B:T329 6.264128
93B:B:W332 7.975119
94B:B:D333 9.1154129
95B:B:L336 4.3475407
96B:B:K337 6.55254126
97B:B:W339 7.835129
98G:G:A23 3.1125408
99G:G:R27 6.2975408
100G:G:Y40 8.19754176
101G:G:D48 6.6685289
102G:G:L50 5.4054289
103G:G:L51 3.03406
104G:G:P60 5.9975499
105G:G:F61 5.24429798
106R:R:Y65 5.04505
107R:R:F70 6.9775407
108R:R:N77 7.9575409
109R:R:F87 6.3875405
110R:R:I93 4.5275406
111R:R:P94 6.668527
112R:R:D95 8.0025428
113R:R:D105 6.626509
114R:R:F117 5.5354324
115R:R:L135 5.8025405
116R:R:Y142 4.94507
117R:R:F147 11.02254188
118R:R:W150 7.7575407
119R:R:R155 8.4625409
120R:R:Y156 5.16408
121R:R:R169 5.936527
122R:R:W216 6.9025355
123R:R:F223 5.5575408
124R:R:P226 3.585409
125R:R:I230 4.2925408
126R:R:Y234 7.6275409
127R:R:R248 5.71754264
128R:R:R253 7.48405
129R:R:R254 7.35506
130R:R:K256 6.3525407
131R:R:W272 7.892509
132R:R:L273 4405
133R:R:F278 6.3754195
134R:R:T305 3.97254195
135R:R:F314 7.1925407
136R:R:Y324 6.598509
137R:R:F331 5.90754278
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:L69 13.7794.07YesNo085
2B:B:I81 B:B:L69 12.86754.28YesNo075
3B:B:H91 B:B:I81 11.49523.98YesYes557
4B:B:D76 B:B:S74 24.62758.83YesNo099
5B:B:H54 B:B:S74 24.537111.16YesNo099
6B:B:H54 B:B:W82 18.53214.23YesYes699
7B:B:D76 B:B:L55 10012.21YesNo096
8A:A:K34 B:B:L55 99.97487.05NoNo056
9A:A:K34 A:A:R38 99.92374.95NoNo054
10A:A:Y37 B:B:D76 80.17984.6NoYes2139
11A:A:R42 A:A:Y37 80.246515.43NoNo093
12A:A:R38 R:R:T170 99.89783.88NoNo046
13A:A:F222 A:A:R42 80.21594.28YesNo079
14A:A:I358 A:A:Y360 19.61398.46NoYes048
15A:A:I358 A:A:Q385 19.76614.12NoNo045
16A:A:Q385 R:R:R253 25.85735.84NoYes055
17A:A:V394 R:R:R253 27.02497.85NoYes085
18A:A:L388 A:A:V394 27.3188.94NoNo088
19A:A:L388 A:A:L393 27.6114.15NoNo088
20A:A:L393 R:R:R155 27.96076.07NoYes089
21A:A:Y391 R:R:R155 56.15313.38YesYes049
22A:A:Y391 R:R:R169 88.35525.14YesYes247
23R:R:F168 R:R:R169 99.70944.28NoYes047
24R:R:F168 R:R:H173 99.76463.39NoNo044
25R:R:H173 R:R:T170 99.871910.95NoNo046
26A:A:D378 A:A:Y360 14.594710.34NoYes078
27A:A:F222 B:B:W99 79.872319.04YesYes779
28A:A:F238 B:B:W99 50.241511.02YesYes799
29A:A:F238 A:A:L44 15.285815.83YesNo099
30A:A:L44 A:A:L46 14.800311.07NoNo098
31A:A:L282 A:A:N279 11.999910.98NoNo098
32A:A:N279 A:A:W281 12.00313.39NoYes085
33A:A:W281 B:B:W332 21.48013.75YesYes1159
34B:B:S316 B:B:W332 11.01536.18NoYes099
35B:B:C317 B:B:S316 11.00723.44NoNo079
36B:B:C317 B:B:M61 11.00074.86NoNo076
37A:A:I276 A:A:L46 14.66694.28YesNo088
38A:A:I276 A:A:R231 22.10435.01YesNo089
39A:A:R231 A:A:W234 22.27159NoYes099
40A:A:F238 A:A:W234 35.04425.01YesYes099
41A:A:F290 A:A:I56 10.22245.02YesNo097
42A:A:W234 B:B:Y145 29.34045.79YesYes098
43A:A:I235 A:A:L282 11.94574.28NoNo099
44B:B:R314 B:B:W332 18.307614.99YesYes1189
45B:B:K57 B:B:Q75 38.24115.42NoNo099
46B:B:K57 B:B:W332 38.08099.28NoYes099
47A:A:F246 A:A:I276 36.1493.77NoYes098
48A:A:F246 A:A:V248 16.10973.93NoYes097
49A:A:F246 A:A:F273 19.75655.36NoYes099
50A:A:E344 A:A:L270 19.28843.98NoYes056
51A:A:F345 A:A:L270 15.30696.09YesYes086
52A:A:W281 B:B:D290 26.38274.47YesYes1156
53B:B:D290 B:B:R314 17.938513.1YesYes1168
54A:A:E344 A:A:F340 15.627313.99NoYes057
55R:R:P94 R:R:T92 10.13416.99YesNo277
56A:A:Y391 R:R:M151 32.97413.59YesNo048
57R:R:M151 R:R:Y324 33.72263.59NoYes089
58R:R:L148 R:R:Y324 70.87557.03NoYes099
59R:R:L101 R:R:L148 17.14116.92NoNo099
60R:R:D105 R:R:L101 16.84798.14YesNo099
61R:R:D105 R:R:N77 13.04296.73YesYes099
62R:R:R155 R:R:Y324 38.16786.17YesYes099
63R:R:L148 R:R:N320 53.4955.49NoNo099
64R:R:D105 R:R:N320 17.21629.42YesNo099
65B:B:C271 B:B:D290 43.82656.22NoYes1156
66B:B:C271 B:B:Y289 39.32254.03NoYes1157
67B:B:W297 B:B:Y289 38.54325.79NoYes087
68B:B:W297 B:B:Y264 37.769410.61NoYes085
69B:B:L252 B:B:Y264 29.01217.03NoYes075
70B:B:L252 B:B:L261 28.72754.15NoNo075
71B:B:L261 G:G:V30 26.22594.47NoNo058
72B:B:Q259 G:G:V30 25.9395.73NoNo068
73B:B:Q259 B:B:R22 25.36445.84NoNo066
74B:B:D258 B:B:R22 17.21314.29YesNo076
75B:B:L51 B:B:W82 12.040717.08YesYes099
76B:B:I338 B:B:L51 11.74744.28NoYes059
77B:B:I338 G:G:F61 11.24217.54NoYes958
78B:B:M101 B:B:Y145 17.87514.79NoYes098
79B:B:H91 B:B:V133 10.58445.54YesNo554
80B:B:G116 B:B:M101 17.52673.49NoNo099
81B:B:G115 B:B:G116 17.35222.11NoNo099
82B:B:G115 B:B:L146 17.17733.42NoNo097
83B:B:I157 B:B:W169 13.51673.52NoYes078
84B:B:D258 B:B:F222 10.29343.58YesYes378
85R:R:N316 R:R:N320 36.768512.26NoNo099
86R:R:N316 R:R:W272 35.913615.82NoYes099
87R:R:F268 R:R:W272 17.021611.02NoYes099
88R:R:F227 R:R:F268 15.19575.36NoNo069
89R:R:D105 R:R:S317 19.33864.42YesNo099
90R:R:L108 R:R:S317 18.75319.01NoNo079
91R:R:F314 R:R:L108 18.59823.65YesNo077
92R:R:F314 R:R:S112 16.748713.21YesNo078
93R:R:S112 R:R:Y65 15.51446.36NoYes085
94R:R:V145 R:R:W272 14.85043.68NoYes089
95R:R:F146 R:R:V145 10.24093.93NoNo068
96B:B:Q75 B:B:W99 38.403710.95NoYes099
97A:A:I235 A:A:W234 12.04683.52NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XOJ
Class A
SubFamily Steroid
Type Estrogen
SubType GPER1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.1
Date 2024-04-10
D.O.I. To be published
Net Summary
Imin 3.39
Number of Linked Nodes 843
Number of Links 973
Number of Hubs 137
Number of Links mediated by Hubs 523
Number of Communities 35
Number of Nodes involved in Communities 197
Number of Links involved in Communities 248
Path Summary
Number Of Nodes in MetaPath 98
Number Of Links MetaPath 97
Number of Shortest Paths 1195750
Length Of Smallest Path 3
Average Path Length 29.8747
Length of Longest Path 56
Minimum Path Strength 1.31
Average Path Strength 7.0322
Maximum Path Strength 18.3
Minimum Path Correlation 0.71
Average Path Correlation 0.979836
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 44.7532
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.8177
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8XOJ_Chain_A
EDKAAVERS KMIEKQLQK DKQVYRRTL RLLLLGADN SGKSTIVKQ 
MRITSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ CFNDVTAII 
FVVDSSDNR LQEALNDFD SIWNNRWLR TISVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRKEFV 
DISTASGDG RHICYPHFT CAVDTENAR RIFNDCKDI ILQMNLREY 
NLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8XOJ_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8XOJ_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99527
Sequence
>8XOJ_Chain_R
SEHQQYVIG LFLSCLYTI FLFPIGFVG NILILVVNI SFREKMTIP 
DLYFINLAV ADLILVADS LIEVFNLHE RYYDIAVLC TFMSLFLQV 
NMYSSVFFL TWMSFDRYI ALARAMRCS LFRTKHHAR LSCGLIWMA 
SVSATLVPF TAVHLQHDV REVQWLEVT LGFIVPFAI IGLCYSLIV 
RVLVRAHRH RRRQKALRM ILAVVLVFF VCWLPENVF ISVHLLQHA 
HPLTGHIVN LAAFSNSCL NPLIYSFLG ETFRDKLRL YIEQK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XOGASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.92024-04-10To be published
8XOHASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22024-04-10To be published
8XOIASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22024-04-10To be published
8XOJASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.12024-04-10To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XOJ.zip



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