Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 5.91010
2R:R:P40 4.9875403
3R:R:V54 3.975407
4R:R:N58 8.6375419
5R:R:F71 6.6825408
6R:R:L82 5.19167619
7R:R:D86 8.386519
8R:R:L112 3.475405
9R:R:L127 7.0225418
10R:R:T153 4.3275426
11R:R:W161 4.232509
12R:R:V187 3.6775415
13R:R:P189 4.974513
14R:R:L190 4.6125413
15R:R:H194 9.235407
16R:R:F202 7.53667618
17R:R:Y213 5.655819
18R:R:R243 3.085405
19R:R:F256 6.2625419
20R:R:W260 8.7618
21R:R:Y266 5.936503
22R:R:Y280 5.705404
23R:R:N289 8.068519
24R:R:M291 4.36405
25R:R:N293 9.555419
26R:R:Y297 6.96519
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:I124 38.007111.26YesNo108
2R:R:I124 R:R:W260 39.8199.4NoYes188
3R:R:N289 R:R:W260 81.710213.56YesYes198
4R:R:N289 R:R:N293 97.563812.26YesYes199
5R:R:D86 R:R:N293 97.8796.73YesYes199
6R:R:D86 R:R:N58 92.569413.46YesYes199
7R:R:N58 R:R:V54 38.35084.43YesYes097
8R:R:M291 R:R:V54 68.5474.56YesYes057
9R:R:M291 R:R:Y288 1005.99YesNo054
10R:R:L284 R:R:Y288 97.61877.03NoNo044
11R:R:L284 R:R:P285 88.27054.93NoNo047
12R:R:P262 R:R:P285 85.86883.9NoNo097
13R:R:P262 R:R:T282 83.46313.5NoNo098
14R:R:T282 R:R:Y266 81.05347.49NoYes083
15R:R:T279 R:R:Y266 64.07124.99NoYes043
16R:R:T279 R:R:Y280 61.62896.24NoYes044
17R:R:D44 R:R:Y280 17.52729.2NoYes044
18R:R:D44 R:R:P40 12.67724.83NoYes043
19L:L:?1 R:R:F202 79.82116.41YesYes108
20R:R:F202 R:R:W260 41.04529.02YesYes188
21R:R:F202 R:R:F256 44.31326.43YesYes189
22R:R:F256 R:R:N289 42.61117.25YesYes199
23R:R:D86 R:R:S290 38.796110.31YesNo099
24R:R:S290 R:R:V54 38.09863.23NoYes097
25R:R:E57 R:R:N58 34.86125.26NoYes189
26R:R:E57 R:R:M291 36.22574.06NoYes085
27R:R:L47 R:R:Y280 34.86733.52NoYes044
28R:R:L283 R:R:L47 32.56744.15NoNo044
29R:R:L283 R:R:T287 30.07422.95NoNo046
30R:R:S50 R:R:T287 10.10077.99NoNo056
31R:R:L93 R:R:T287 17.48652.95NoNo066
32R:R:G51 R:R:V94 10.11691.84NoNo056
33R:R:N58 R:R:P294 19.402111.4YesNo199
34R:R:P294 R:R:V61 20.67313.53NoNo099
35R:R:A83 R:R:V61 18.08033.39NoNo099
36R:R:A83 R:R:G80 15.45091.95NoNo096
37R:R:G80 R:R:I65 13.67771.76NoNo067
38R:R:F76 R:R:I65 12.7856.28NoNo097
39R:R:L127 R:R:N289 26.85514.12YesYes189
40R:R:L127 R:R:L82 27.68486.92YesYes189
41R:R:L82 R:R:S126 33.46216.01YesNo098
42R:R:S126 R:R:S81 31.98374.89NoNo089
43R:R:L157 R:R:S81 23.0283NoNo079
44R:R:L157 R:R:T153 19.98372.95NoYes276
45R:R:L82 R:R:N293 12.65076.87YesYes199
46R:R:L127 R:R:Y297 41.34624.69YesYes189
47R:R:L77 R:R:T153 10.85924.42NoYes046
48R:R:I130 R:R:L82 16.11394.28NoYes099
49R:R:I130 R:R:Y297 15.31277.25NoYes099
50L:L:?1 R:R:L190 33.19786.07YesYes103
51R:R:L190 R:R:V113 21.2754.47YesNo134
52R:R:H96 R:R:V113 20.00812.77NoNo054
53R:R:H96 R:R:L112 16.45142.57NoYes055
54L:L:?1 R:R:V187 22.73115.22YesYes105
55R:R:P189 R:R:V187 10.91613.53YesYes135
56R:R:L110 R:R:P189 14.27151.64NoYes053
57R:R:L190 R:R:P189 10.57044.93YesYes133
58L:L:?1 R:R:L198 44.132210.92YesNo006
59R:R:H194 R:R:L198 39.176412.86YesNo076
60L:L:?1 R:R:G125 10.91813YesNo005
61R:R:L212 R:R:T131 12.79515.9NoNo068
62R:R:Y213 R:R:Y297 41.54754.96YesYes199
63R:R:T131 R:R:Y213 13.584111.24NoYes189
64R:R:I216 R:R:Y213 13.82412.42NoYes099
65R:R:H194 R:R:L170 12.723915.43YesNo074
66R:R:A174 R:R:L170 10.91811.58NoNo044
67R:R:H194 R:R:N176 18.11692.55YesNo075
68R:R:L195 R:R:V187 11.05852.98NoYes055
69R:R:L249 R:R:Y213 14.00512.34NoYes079
70R:R:C217 R:R:L249 12.01423.17NoNo067
71R:R:C217 R:R:C221 10.02141.82NoNo066
72R:R:Y266 R:R:Y278 10.14957.94YesNo033
73R:R:D86 R:R:L82 34.00514.07YesYes199
74R:R:L127 R:R:N293 13.159112.36YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:T121 5.17 1 Yes No 0 6 0 1
L:L:?1 R:R:I124 11.26 1 Yes No 0 8 0 1
L:L:?1 R:R:G125 3 1 Yes No 0 5 0 1
L:L:?1 R:R:V187 5.22 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L190 6.07 1 Yes Yes 0 3 0 1
L:L:?1 R:R:L198 10.92 1 Yes No 0 6 0 1
L:L:?1 R:R:F202 6.41 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V205 3.92 1 Yes No 0 8 0 1
L:L:?1 R:R:F263 4.27 1 Yes No 0 6 0 1
R:R:P189 R:R:V113 10.6 1 Yes No 3 4 2 2
R:R:L190 R:R:V113 4.47 1 Yes No 3 4 1 2
R:R:A164 R:R:T121 3.36 0 No No 8 6 2 1
R:R:L167 R:R:T121 5.9 0 No No 6 6 2 1
R:R:I124 R:R:V205 4.61 1 No No 8 8 1 1
R:R:I124 R:R:W260 9.4 1 No Yes 8 8 1 2
R:R:G125 R:R:V160 3.68 0 No No 5 6 1 2
R:R:L128 R:R:V205 5.96 0 No No 7 8 2 1
R:R:L167 R:R:L198 5.54 0 No No 6 6 2 1
R:R:P189 R:R:V187 3.53 1 Yes Yes 3 5 2 1
R:R:L190 R:R:V187 2.98 1 Yes Yes 3 5 1 1
R:R:L195 R:R:V187 2.98 0 No Yes 5 5 2 1
R:R:L190 R:R:P189 4.93 1 Yes Yes 3 3 1 2
R:R:H194 R:R:L198 12.86 0 Yes No 7 6 2 1
R:R:C267 R:R:L195 7.94 0 No No 6 5 2 2
R:R:F202 R:R:F203 5.36 1 Yes No 8 4 1 2
R:R:F202 R:R:F256 6.43 1 Yes Yes 8 9 1 2
R:R:F202 R:R:W260 9.02 1 Yes Yes 8 8 1 2
R:R:F202 R:R:T264 15.56 1 Yes No 8 5 1 2
R:R:F203 R:R:T264 7.78 1 No No 4 5 2 2
R:R:F256 R:R:W260 6.01 1 Yes Yes 9 8 2 2
R:R:C267 R:R:F263 8.38 0 No No 6 6 2 1
L:L:?1 R:R:A201 2.76 1 Yes No 0 4 0 1
R:R:F202 R:R:L261 2.44 1 Yes No 8 4 1 2
R:R:F203 R:R:L261 2.44 1 No No 4 4 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8U8F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.95
Number of Linked Nodes 242
Number of Links 263
Number of Hubs 26
Number of Links mediated by Hubs 103
Number of Communities 4
Number of Nodes involved in Communities 37
Number of Links involved in Communities 53
Path Summary
Number Of Nodes in MetaPath 75
Number Of Links MetaPath 74
Number of Shortest Paths 100028
Length Of Smallest Path 3
Average Path Length 16.7142
Length of Longest Path 33
Minimum Path Strength 1.165
Average Path Strength 6.1622
Maximum Path Strength 14.145
Minimum Path Correlation 0.7
Average Path Correlation 0.930127
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 45.804
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.4125
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • bioactive lipid receptor activity   • sphingosine-1-phosphate receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • metabolic process   • regulation of metabolic process   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of cellular process   • regulation of cellular component organization   • sexual reproduction   • regulation of reproductive process   • reproductive process   • meiotic cell cycle process   • cellular component organization   • meiotic nuclear division   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • cell cycle process   • regulation of meiotic cell cycle   • regulation of cell cycle process   • meiotic cell cycle   • organelle fission   • regulation of organelle organization   • regulation of meiotic nuclear division   • organelle organization   • nuclear division   • regulation of nuclear division
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodePLM
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodePLM
NamePalmitic Acid
SynonymsPalmitinsäure
Identifier
FormulaC16 H32 O2
Molecular Weight256.424
SMILES
PubChem985
Formal Charge0
Total Atoms50
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP46089
Sequence
>8U8F_nogp_Chain_R
SPKAWDVVL CISGTLVSC ENALVVAII VGTPAFRAP MFLLVGSLA 
VADLLAGLG LVLHFAAVF CIGSAEMSL VLVGVLAMA FTASIGSLL 
AITVDRYLS LYNALTYYS ETTVTRTYV MLALVWGGA LGLGLLPVL 
AWNCLDGLT TCGVVYPLS KNHLVVLAI AFFMVFGIM LQLYAQICR 
IVCRHAQQI ALQRHRKGI ATLAVVLGA FAACWLPFT VYCLLGDAH 
SPPLYTYLT LLPATYNSM INPIIYAFR NQDVQKVLW AVCC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8H8JAOrphanOrphanGPR35Homo sapiensLodoxamideCachim(NtGi1L-G13)/β1/γ23.22023-02-08doi.org/10.1038/s41421-022-00499-8
8H8J (No Gprot) AOrphanOrphanGPR35Homo sapiensLodoxamideCa3.22023-02-08doi.org/10.1038/s41421-022-00499-8
8U8FAOrphanOrphanGPR3Homo sapiensPalmitic Acid-Gs/β1/γ23.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8U8F (No Gprot) AOrphanOrphanGPR3Homo sapiensPalmitic Acid-3.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8WW2AOrphanOrphanGPR3Homo sapiens--chim(NtGi1-Gs)/β1/γ22.792024-02-14doi.org/10.1038/s41422-024-00932-5
8WW2 (No Gprot) AOrphanOrphanGPR3Homo sapiens--2.792024-02-14doi.org/10.1038/s41422-024-00932-5
9LYBAOrphanOrphanGPR3Homo sapiens--Gs/β1/γ23.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYB (No Gprot) AOrphanOrphanGPR3Homo sapiens--3.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYCAOrphanOrphanGPR3Homo sapiens--Gs/β1/γ23.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYC (No Gprot) AOrphanOrphanGPR3Homo sapiens--3.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYDAOrphanOrphanGPR3Homo sapiens---3.662025-04-09doi.org/10.1016/j.celrep.2025.115478
8X2KAOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-chim(NtGi1-Gs)/β1/γ23.032024-04-03doi.org/10.1038/s41422-023-00919-8
8X2K (No Gprot) AOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-3.032024-04-03doi.org/10.1038/s41422-023-00919-8
8XOFAOrphanOrphanGPR30Homo sapiensLys05-chim(NtGi1-Gs-CtGq)/β1/γ22.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOF (No Gprot) AOrphanOrphanGPR30Homo sapiensLys05-2.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOGAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOG (No Gprot) AOrphanOrphanGPR30Homo sapiens--2.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOHAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOH (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOIAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOI (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.12024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJ (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.12024-04-10doi.org/10.1038/s41422-024-00963-y
8XBEAOrphanOrphanGPR34Homo sapiensS3E-LysoPS-Gi1/β1/γ13.42024-05-15doi.org/10.1038/s41467-024-45046-z
8XBE (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-LysoPS-3.42024-05-15doi.org/10.1038/s41467-024-45046-z
8XBGAOrphanOrphanGPR34Homo sapiensS3E-LysoPS--3.432024-05-15doi.org/10.1038/s41467-024-45046-z
8SAIAOrphanOrphanGPR34Homo sapiens1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ23.272023-10-04doi.org/10.1073/pnas.2308435120
8SAI (No Gprot) AOrphanOrphanGPR34Homo sapiens1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-3.272023-10-04doi.org/10.1073/pnas.2308435120
8IYXAOrphanOrphanGPR34Homo sapiensYL-365--3.342024-03-20doi.org/10.1073/pnas.2308435120
8WRBAOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-Gi1/β1/γ22.912023-11-08doi.org/10.1371/journal.pbio.3002387
8WRB (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-2.912023-11-08doi.org/10.1371/journal.pbio.3002387
8XBHAOrphanOrphanGPR34Homo sapiensS3E-LysoPS-Gi1/β1/γ22.832023-12-27doi.org/10.1038/s41467-024-45046-z
8XBH (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-LysoPS-2.832023-12-27doi.org/10.1038/s41467-024-45046-z
8XBIAOrphanOrphanGPR34Homo sapiensS3E-LysoPS--3.062023-12-27doi.org/10.1038/s41467-024-45046-z
8K4NAOrphanOrphanGPR34Homo sapiensVF0-Gi1/β1/γ22.832023-10-25To be published
8K4N (No Gprot) AOrphanOrphanGPR34Homo sapiensVF0-2.832023-10-25To be published
8IZ4AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-Gi1/β1/γ22.942024-04-10To be published
8IZ4 (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-2.942024-04-10To be published




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