Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 4.994154
2A:A:K53 7.4325409
3A:A:F219 5.74408
4A:A:H220 9.37754167
5A:A:F222 8.0165167
6A:A:K233 5.832519
7A:A:W234 5.996509
8A:A:F238 10.1925409
9A:A:I244 4.08408
10A:A:F273 5.688336219
11A:A:W277 10.244216
12A:A:W281 10.4633615
13A:A:I288 5.1125449
14A:A:F290 5.53509
15A:A:K293 6.14254229
16A:A:L296 3.89754226
17A:A:F312 6.0465178
18A:A:E314 8.48254176
19A:A:F315 7.818506
20A:A:P321 5.194575
21A:A:E330 8.1075473
22A:A:D331 6.81754244
23A:A:V334 2.705404
24A:A:Y339 7.144573
25A:A:F340 8.6125177
26A:A:R342 7.5625474
27A:A:E344 7.784175
28A:A:F345 8.665408
29A:A:Y358 4.118544
30A:A:Y360 8.09833648
31A:A:F363 7.3725475
32A:A:Q384 5.7375446
33A:A:R385 10.226545
34A:A:H387 6.194598
35A:A:L388 6.26408
36B:B:L7 4.6365118
37B:B:L14 3.475408
38B:B:T34 5.5754105
39B:B:I37 4.564102
40B:B:V40 4.3285103
41B:B:R48 7.5225427
42B:B:H54 12.54409
43B:B:K57 10.094519
44B:B:Y59 6.87333618
45B:B:M61 4.676526
46B:B:W63 6.998527
47B:B:Q75 8.632519
48B:B:K78 5.345408
49B:B:L79 4.555407
50B:B:W82 10.0167629
51B:B:D83 7.084158
52B:B:K89 6.78529
53B:B:L95 4.9025408
54B:B:W99 12.1925409
55B:B:M101 5.08419
56B:B:C121 3.2475408
57B:B:I123 3.4665126
58B:B:Y124 8.62406
59B:B:N125 5.164124
60B:B:H142 8.946569
61B:B:Y145 6.23518
62B:B:F151 4.475609
63B:B:L152 4.298503
64B:B:T159 5.332569
65B:B:D163 9.47469
66B:B:W169 9.70714768
67B:B:F180 6.366537
68B:B:H183 9.10167639
69B:B:V187 4.685439
70B:B:R197 9.7875405
71B:B:V200 4.98406
72B:B:S201 5.96439
73B:B:D205 5.765439
74B:B:K209 10.9775436
75B:B:W211 8.445638
76B:B:D212 5.05409
77B:B:C218 4.75435
78B:B:H225 6.97759
79B:B:I232 4.705408
80B:B:F235 8.432586
81B:B:N237 7.7485
82B:B:F241 7.955406
83B:B:T243 6.24458
84B:B:D247 8.716559
85B:B:R251 6.32714758
86B:B:F253 6.3025456
87B:B:D258 9.175137
88B:B:Y264 4.1675405
89B:B:F278 6.54487
90B:B:R283 5.4045109
91B:B:Y289 6.56429717
92B:B:D290 5.3375416
93B:B:N293 4.2925415
94B:B:N295 5.672516
95B:B:K301 6.4925405
96B:B:G306 2.1375404
97B:B:V307 4.3525413
98B:B:H311 8.9409
99B:B:R314 12.79518
100B:B:L318 3.916506
101B:B:V320 3.624267
102B:B:M325 4.40667625
103B:B:V327 4.18254266
104B:B:W332 9.02125819
105B:B:L336 4.405427
106B:B:W339 11.2675409
107B:B:N340 8.895429
108G:G:V16 4.11254117
109G:G:K20 4.93754116
110G:G:Y40 9.19486
111G:G:D48 7.01409
112G:G:L51 3.0445106
113G:G:N59 6.15667629
114G:G:P60 5.6475429
115G:G:F61 5.29143728
116R:R:P40 8.15254183
117R:R:W43 5.4475403
118R:R:D44 5.6465184
119R:R:V54 5.08407
120R:R:T68 6.05254297
121R:R:F71 7.624298
122R:R:D86 7.7825409
123R:R:F97 8.05754185
124R:R:F101 10.9985184
125R:R:I124 3.8985198
126R:R:Y144 7.34798
127R:R:R152 8.144597
128R:R:W161 3.8509
129R:R:L169 2.57254303
130R:R:H194 6.1075407
131R:R:F202 5.3825198
132R:R:Y213 5.232867149
133R:R:H223 7.138547
134R:R:F256 5.5365199
135R:R:W260 8.278577198
136R:R:Y266 6.43333603
137R:R:Y297 5.102509
138R:R:F299 5.50754285
139R:R:V307 3.7254298
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:K78 19.49689.68NoYes098
2B:B:D76 B:B:L55 26.000313.57NoNo096
3A:A:Y37 B:B:L55 26.45697.03NoNo046
4A:A:R42 A:A:Y37 27.238813.38NoNo094
5A:A:F222 A:A:R42 10.29133.21YesNo079
6B:B:L284 B:B:V296 14.83254.47NoNo055
7B:B:L286 B:B:V296 15.15044.47NoNo075
8B:B:L318 B:B:T329 67.34454.42YesNo068
9B:B:H311 B:B:T329 66.56336.85YesNo098
10B:B:H311 B:B:K337 65.71047.86YesNo096
11B:B:K337 B:B:T50 65.85883NoNo063
12B:B:R52 B:B:T50 65.73119.06NoNo073
13B:B:R52 R:R:P69 65.828810.09NoNo075
14R:R:P69 R:R:T68 65.70063.5NoYes057
15R:R:T68 R:R:V307 63.86684.76YesYes2978
16R:R:I64 R:R:V307 644.61NoYes088
17R:R:I64 R:R:L60 63.86755.71NoNo087
18R:R:F299 R:R:L60 63.38176.09YesNo2857
19R:R:E57 R:R:F299 62.66415.83NoYes085
20R:R:E57 R:R:M291 62.3945.41NoNo085
21R:R:M291 R:R:V54 62.12293.04NoYes057
22R:R:S290 R:R:V54 61.71458.08NoYes097
23R:R:D86 R:R:S290 61.577910.31YesNo099
24R:R:D86 R:R:N293 60.33746.73YesNo099
25R:R:L82 R:R:N293 60.198310.98NoNo099
26R:R:L127 R:R:L82 57.1872.77NoNo089
27R:R:L127 R:R:Y297 35.933.52NoYes089
28R:R:R134 R:R:Y297 34.64286.17NoYes099
29R:R:R134 R:R:Y213 32.94755.14NoYes099
30R:R:I216 R:R:Y213 31.7394.84NoYes099
31R:R:I216 R:R:L138 30.15454.28NoNo098
32A:A:L388 R:R:L138 14.68238.3YesNo088
33A:A:L388 R:R:H223 14.36273.86YesYes087
34A:A:D381 R:R:H223 27.89678.82NoYes487
35A:A:D381 A:A:Y360 25.074110.34NoYes488
36A:A:I382 A:A:Y360 14.2867.25NoYes068
37A:A:I382 A:A:T242 13.47763.04NoNo068
38A:A:L43 A:A:T242 13.07312.95NoNo078
39R:R:I219 R:R:L138 15.28927.14NoNo068
40R:R:H223 R:R:I219 14.28853.98YesNo476
41A:A:D240 A:A:R42 21.66064.76NoNo069
42A:A:F222 B:B:W99 11.158919.04YesYes079
43A:A:F238 B:B:W99 10012.03YesYes099
44A:A:F238 A:A:L44 48.763319.49YesNo099
45A:A:I244 A:A:L44 48.16647.14YesNo089
46A:A:F238 A:A:V241 48.44585.24YesNo099
47A:A:I244 A:A:V241 48.14743.07YesNo089
48B:B:M101 B:B:Y145 30.57447.18YesYes198
49B:B:M101 B:B:Y59 18.95144.79YesYes198
50A:A:D240 B:B:K57 11.96725.53NoYes169
51B:B:D186 B:B:Y145 13.09639.2NoYes198
52A:A:R228 B:B:D186 12.92997.15NoNo099
53A:A:R228 B:B:T164 12.43525.17NoNo096
54A:A:K233 B:B:Y145 16.51524.78YesYes198
55A:A:K233 B:B:N230 15.67765.6YesNo099
56A:A:N239 B:B:W332 10.02076.78NoYes189
57B:B:K57 B:B:W332 47.02759.28YesYes199
58A:A:W281 B:B:W332 25.31176.56YesYes159
59B:B:R314 B:B:W332 73.762726.99YesYes189
60A:A:C237 B:B:Q75 12.09863.05NoYes189
61B:B:K57 B:B:Q75 37.191414.92YesYes199
62B:B:Q75 B:B:W99 97.867413.14YesYes099
63A:A:I244 A:A:V287 95.08133.07YesNo086
64A:A:F273 A:A:V287 59.58716.55YesNo2196
65A:A:F273 A:A:F345 26.74147.5YesYes098
66A:A:F345 A:A:L289 20.467915.83YesNo089
67A:A:L289 A:A:L291 19.83538.3NoNo098
68A:A:I341 A:A:L291 17.90474.28NoNo088
69A:A:I341 A:A:L266 15.98685.71NoNo088
70A:A:F312 A:A:L266 15.34844.87YesNo088
71A:A:V287 A:A:W277 34.87814.9NoYes2166
72A:A:C359 A:A:F273 27.97874.19NoYes059
73A:A:S349 A:A:W277 29.86543.71NoYes076
74A:A:W281 B:B:D290 24.89728.93YesYes156
75B:B:D290 B:B:R314 38.46535.96YesYes168
76A:A:C359 A:A:P361 27.34715.65NoNo055
77A:A:P361 A:A:R342 26.71768.65NoYes054
78A:A:L346 A:A:S349 27.34066.01NoNo047
79A:A:L346 A:A:R342 26.70924.86NoYes044
80A:A:R342 A:A:Y339 49.60789.26YesYes743
81A:A:K338 A:A:Y339 17.90568.36NoYes753
82A:A:E330 A:A:K338 12.790913.5YesNo735
83A:A:E309 A:A:F315 19.1389.33NoYes046
84A:A:E309 A:A:K307 15.31085.4NoNo046
85A:A:F315 A:A:F340 13.41411.79YesYes067
86A:A:P321 A:A:Y339 29.35838.34YesYes753
87A:A:P321 A:A:Y318 14.06855.56YesNo056
88A:A:F340 A:A:Y318 10.25016.19YesNo076
89A:A:P321 A:A:T320 11.48443.5YesNo051
90A:A:R336 A:A:T320 10.20975.17NoNo051
91B:B:C271 B:B:D290 62.82383.11NoYes156
92B:B:C271 B:B:Y289 60.02834.03NoYes157
93B:B:I273 B:B:Y289 44.699.67NoYes067
94B:B:G244 B:B:I273 44.15925.29NoNo056
95B:B:G244 B:B:H225 43.38563.18NoYes059
96B:B:H225 B:B:T243 37.60799.58YesYes598
97B:B:I232 B:B:T243 24.24634.56YesYes088
98B:B:F241 B:B:I232 13.40725.02YesYes068
99B:B:F222 B:B:F241 39.88949.65NoYes086
100B:B:D258 B:B:F222 36.15335.97YesNo1378
101B:B:D258 B:B:R22 31.181711.91YesNo076
102B:B:I18 B:B:R22 29.93746.26NoNo076
103B:B:I18 G:G:A23 28.69281.62NoNo078
104B:B:L14 G:G:A23 26.20281.58YesNo088
105B:B:L14 G:G:K20 19.97374.23YesYes086
106G:G:K20 G:G:V16 16.23176.07YesYes1167
107B:B:L7 G:G:V16 13.73852.98YesYes1187
108B:B:F253 B:B:T243 13.27817.78YesYes568
109B:B:F241 B:B:F253 28.73539.65YesYes066
110B:B:H225 B:B:R251 14.85389.03YesYes598
111B:B:F253 B:B:R251 16.40354.28YesYes568
112B:B:W297 B:B:Y264 17.54075.79NoYes085
113B:B:G185 B:B:T164 12.24391.82NoNo056
114B:B:G185 B:B:T184 12.05281.82NoNo053
115B:B:D205 B:B:T184 11.8634.34YesNo093
116B:B:D205 B:B:H183 11.01153.78YesYes399
117B:B:K78 B:B:P94 10.75113.35YesNo085
118B:B:I93 B:B:P94 10.47273.39NoNo075
119B:B:I232 B:B:V200 11.3176.14YesYes086
120B:B:L210 B:B:V200 10.43112.98NoYes056
121B:B:D246 B:B:N230 15.55016.73NoNo099
122B:B:D246 B:B:S227 15.42815.89NoNo096
123B:B:S227 B:B:S245 15.36823.26NoNo069
124B:B:L318 B:B:S275 62.91586.01YesNo068
125B:B:R314 B:B:T274 63.07935.17YesNo088
126R:R:F256 R:R:L127 27.13257.31YesNo098
127R:R:F256 R:R:W260 20.66758.02YesYes1998
128R:R:F263 R:R:W260 14.81543.01NoYes068
129R:R:C267 R:R:F263 14.61216.98NoNo066
130B:B:W297 B:B:Y289 17.60725.79NoYes187
131B:B:H225 B:B:S245 11.689212.55YesNo599
132B:B:S275 B:B:T274 62.99073.2NoNo088
133B:B:Q75 B:B:Y59 49.12779.02YesYes198
134B:B:W332 B:B:Y59 42.14458.68YesYes198
135A:A:C237 B:B:M101 12.064.86NoYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9LYB
Class A
SubFamily Orphan
Type Orphan
SubType GPR3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.16
Date 2025-04-09
D.O.I. doi.org/10.1016/j.celrep.2025.115478
Net Summary
Imin 2.98
Number of Linked Nodes 846
Number of Links 993
Number of Hubs 139
Number of Links mediated by Hubs 524
Number of Communities 30
Number of Nodes involved in Communities 199
Number of Links involved in Communities 275
Path Summary
Number Of Nodes in MetaPath 136
Number Of Links MetaPath 135
Number of Shortest Paths 1486646
Length Of Smallest Path 3
Average Path Length 31.7364
Length of Longest Path 73
Minimum Path Strength 1.1
Average Path Strength 6.87869
Maximum Path Strength 20.555
Minimum Path Correlation 0.7
Average Path Correlation 0.982274
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 41.6158
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.7784
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • metabolic process   • regulation of metabolic process   • multicellular organismal process   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of cellular process   • regulation of cellular component organization   • sexual reproduction   • regulation of reproductive process   • reproductive process   • meiotic cell cycle process   • cellular component organization   • meiotic nuclear division   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • cell cycle process   • regulation of meiotic cell cycle   • regulation of cell cycle process   • meiotic cell cycle   • organelle fission   • regulation of organelle organization   • regulation of meiotic nuclear division   • organelle organization   • nuclear division   • regulation of nuclear division   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • intracellular anatomical structure   • cytoplasm   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9LYB_Chain_A
KTEDQRNEE KAQREANKK IEKQLQKDK QVYRATHRL LLLGAGESG 
KTIVKQMRI LHTSGIFET KFQVDKVNF HMFDVGQRD ERRKWIQCF 
NDVTAIIFV VASSSYQTN RLQALLFSI WNNWLRSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH 
LRQYELLNA AKDKDT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9LYB_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9LYB_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46089
Sequence
>9LYB_Chain_R
LPSPKAWDV VLCISGTLV SCENALVVA IIVGTPAFR APMFLLVGS 
LAVADLLAG LGLVLHFAA VFCIGSAEM SLVLVGVLA MAFTASIGS 
LLAITVDRY LSLYNALTY YSETTVTRT YVMLALVWG GALGLGLLP 
VLAWNCLDG LTTCGVVYP LSKNHLVVL AIAFFMVFG IMLQLYAQI 
CRIVCRHAQ QIALQRHLL TRKGIATLA VVLGAFAAC WLPFTVYCL 
LGDAHSPPL YTYLTLLPA TYNSMINPI IYAFRNQDV QKVLWAVCC 
CC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8H8JAOrphanOrphanGPR35Homo sapiensLodoxamideCachim(NtGi1L-G13)/β1/γ23.22023-02-08doi.org/10.1038/s41421-022-00499-8
8H8J (No Gprot) AOrphanOrphanGPR35Homo sapiensLodoxamideCa3.22023-02-08doi.org/10.1038/s41421-022-00499-8
8U8FAOrphanOrphanGPR3Homo sapiensPalmitic Acid-Gs/β1/γ23.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8U8F (No Gprot) AOrphanOrphanGPR3Homo sapiensPalmitic Acid-3.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8WW2AOrphanOrphanGPR3Homo sapiens--chim(NtGi1-Gs)/β1/γ22.792024-02-14doi.org/10.1038/s41422-024-00932-5
8WW2 (No Gprot) AOrphanOrphanGPR3Homo sapiens--2.792024-02-14doi.org/10.1038/s41422-024-00932-5
9LYBAOrphanOrphanGPR3Homo sapiens--Gs/β1/γ23.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYB (No Gprot) AOrphanOrphanGPR3Homo sapiens--3.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYCAOrphanOrphanGPR3Homo sapiens--Gs/β1/γ23.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYC (No Gprot) AOrphanOrphanGPR3Homo sapiens--3.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYDAOrphanOrphanGPR3Homo sapiens---3.662025-04-09doi.org/10.1016/j.celrep.2025.115478
8X2KAOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-chim(NtGi1-Gs)/β1/γ23.032024-04-03doi.org/10.1038/s41422-023-00919-8
8X2K (No Gprot) AOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-3.032024-04-03doi.org/10.1038/s41422-023-00919-8
8XOFAOrphanOrphanGPR30Homo sapiensLys05-chim(NtGi1-Gs-CtGq)/β1/γ22.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOF (No Gprot) AOrphanOrphanGPR30Homo sapiensLys05-2.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOGAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOG (No Gprot) AOrphanOrphanGPR30Homo sapiens--2.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOHAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOH (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOIAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOI (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.12024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJ (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.12024-04-10doi.org/10.1038/s41422-024-00963-y
8XBEAOrphanOrphanGPR34Homo sapiensS3E-LysoPS-Gi1/β1/γ13.42024-05-15doi.org/10.1038/s41467-024-45046-z
8XBE (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-LysoPS-3.42024-05-15doi.org/10.1038/s41467-024-45046-z
8XBGAOrphanOrphanGPR34Homo sapiensS3E-LysoPS--3.432024-05-15doi.org/10.1038/s41467-024-45046-z
8SAIAOrphanOrphanGPR34Homo sapiens1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ23.272023-10-04doi.org/10.1073/pnas.2308435120
8SAI (No Gprot) AOrphanOrphanGPR34Homo sapiens1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-3.272023-10-04doi.org/10.1073/pnas.2308435120
8IYXAOrphanOrphanGPR34Homo sapiensYL-365--3.342024-03-20doi.org/10.1073/pnas.2308435120
8WRBAOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-Gi1/β1/γ22.912023-11-08doi.org/10.1371/journal.pbio.3002387
8WRB (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-2.912023-11-08doi.org/10.1371/journal.pbio.3002387
8XBHAOrphanOrphanGPR34Homo sapiensS3E-LysoPS-Gi1/β1/γ22.832023-12-27doi.org/10.1038/s41467-024-45046-z
8XBH (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-LysoPS-2.832023-12-27doi.org/10.1038/s41467-024-45046-z
8XBIAOrphanOrphanGPR34Homo sapiensS3E-LysoPS--3.062023-12-27doi.org/10.1038/s41467-024-45046-z
8K4NAOrphanOrphanGPR34Homo sapiensVF0-Gi1/β1/γ22.832023-10-25To be published
8K4N (No Gprot) AOrphanOrphanGPR34Homo sapiensVF0-2.832023-10-25To be published
8IZ4AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-Gi1/β1/γ22.942024-04-10To be published
8IZ4 (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-2.942024-04-10To be published




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Download 9LYB.zip



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