psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	I:I:?1	R:R:R164	4.47	No	Yes	1	0	5
2	I:I:?1	R:R:R255	15.63	No	Yes	1	0	4
3	L:L:?1	R:R:L80	15.19	Yes	No	1	0	5
4	L:L:?1	R:R:F163	41.88	Yes	Yes	1	0	4
5	L:L:?1	R:R:R164	8	Yes	Yes	1	0	5
6	L:L:?1	R:R:L237	5.06	Yes	Yes	1	0	6
7	L:L:?1	R:R:R240	3.55	Yes	Yes	1	0	5
8	L:L:?1	R:R:R255	15.11	Yes	Yes	1	0	4
9	L:L:?1	R:R:L258	4.05	Yes	No	1	0	5
10	L:L:?1	R:R:Y259	9.43	Yes	Yes	0	0	4
11	L:L:?1	R:R:S262	7.69	Yes	No	0	0	6
12	R:R:N6	R:R:W245	5.65	No	No	0	6	1
13	R:R:C8	R:R:G9	3.92	No	No	0	6	6
14	R:R:E252	R:R:S11	5.75	No	No	0	4	6
15	R:R:D12	R:R:R81	13.1	No	No	0	7	3
16	R:R:L13	R:R:R255	20.65	No	Yes	0	2	4
17	R:R:L13	R:R:R256	7.29	No	No	0	2	2
18	R:R:I19	R:R:W15	4.7	No	Yes	0	1	2
19	R:R:R256	R:R:W15	7	No	Yes	0	2	2
20	R:R:W15	R:R:Y259	8.68	Yes	Yes	0	2	4
21	R:R:I260	R:R:W15	4.7	No	Yes	0	5	2
22	R:R:I19	R:R:P16	10.16	No	No	0	1	3
23	R:R:F23	R:R:I19	5.02	No	No	0	4	1
24	R:R:K20	R:R:Y24	15.53	No	No	0	2	4
25	R:R:F23	R:R:Y259	6.19	No	Yes	0	4	4
26	R:R:F23	R:R:I260	6.28	No	No	0	4	5
27	R:R:L27	R:R:L77	5.54	No	No	0	8	7
28	R:R:K263	R:R:L27	5.64	Yes	No	0	4	8
29	R:R:C270	R:R:L30	4.76	No	No	0	7	7
30	R:R:L31	R:R:P74	3.28	No	No	0	6	9
31	R:R:L33	R:R:L37	6.92	No	Yes	0	5	7
32	R:R:G34	R:R:L37	3.42	No	Yes	0	8	7
33	R:R:C270	R:R:G34	3.92	No	No	0	7	8
34	R:R:L35	R:R:L67	4.15	No	No	0	6	7
35	R:R:L35	R:R:L70	4.15	No	No	0	6	5
36	R:R:A273	R:R:L37	4.73	No	Yes	0	9	7
37	R:R:L37	R:R:Y278	10.55	Yes	No	0	7	7
38	R:R:D66	R:R:N38	12.12	Yes	No	0	9	9
39	R:R:L40	R:R:Y278	4.69	No	No	0	6	7
40	R:R:A41	R:R:Y277	5.34	No	Yes	0	8	7
41	R:R:L42	R:R:V64	4.47	No	No	0	7	5
42	R:R:F45	R:R:V44	3.93	Yes	No	0	6	6
43	R:R:F283	R:R:V44	5.24	Yes	No	0	8	6
44	R:R:F45	R:R:M49	11.2	Yes	No	0	6	5
45	R:R:F45	R:R:M59	6.22	Yes	No	2	6	8
46	R:R:F45	R:R:T60	3.89	Yes	No	0	6	5
47	R:R:F45	R:R:Y277	6.19	Yes	Yes	2	6	7
48	R:R:M49	R:R:R56	4.96	No	No	0	5	7
49	R:R:R56	R:R:W52	38.99	No	No	0	7	6
50	R:R:E54	R:R:Y58	13.47	Yes	Yes	2	6	7
51	R:R:D113	R:R:E54	16.89	Yes	Yes	2	8	6
52	R:R:E54	R:R:R128	15.12	Yes	Yes	2	6	7
53	R:R:A133	R:R:E54	4.53	No	Yes	2	8	6
54	R:R:A133	R:R:I57	4.87	No	No	0	8	6
55	R:R:A109	R:R:Y58	5.34	No	Yes	0	6	7
56	R:R:I110	R:R:Y58	4.84	No	Yes	2	8	7
57	R:R:D113	R:R:Y58	4.6	Yes	Yes	2	8	7
58	R:R:A133	R:R:Y58	5.34	No	Yes	2	8	7
59	R:R:V136	R:R:Y58	7.57	No	Yes	0	6	7
60	R:R:M59	R:R:Y276	3.59	No	Yes	2	8	9
61	R:R:M59	R:R:Y277	9.58	No	Yes	2	8	7
62	R:R:L106	R:R:N61	4.12	No	No	0	7	9
63	R:R:C137	R:R:N61	11.02	No	No	0	6	9
64	R:R:N61	R:R:W141	5.65	No	No	0	9	9
65	R:R:D66	R:R:L62	8.14	Yes	Yes	0	9	9
66	R:R:D272	R:R:L62	4.07	No	Yes	0	9	9
67	R:R:L62	R:R:Y277	5.86	Yes	Yes	0	9	7
68	R:R:A63	R:R:Y277	4	No	Yes	0	8	7
69	R:R:C269	R:R:D66	10.89	No	Yes	0	8	9
70	R:R:C68	R:R:N99	7.87	No	Yes	0	7	8
71	R:R:L69	R:R:Y96	7.03	Yes	Yes	1	7	6
72	R:R:L69	R:R:N99	6.87	Yes	Yes	1	7	8
73	R:R:D266	R:R:L69	4.07	Yes	Yes	1	7	7
74	R:R:C269	R:R:L69	6.35	No	Yes	0	8	7
75	R:R:C269	R:R:L70	6.35	No	No	0	8	5
76	R:R:I95	R:R:T72	4.56	No	No	1	5	6
77	R:R:N99	R:R:T72	4.39	Yes	No	1	8	6
78	R:R:L73	R:R:P74	3.28	No	No	0	8	9
79	R:R:L73	R:R:L77	6.92	No	No	0	8	7
80	R:R:D266	R:R:L73	8.14	Yes	No	0	7	8
81	R:R:S92	R:R:V76	4.85	No	No	0	5	6
82	R:R:Q93	R:R:V76	5.73	Yes	No	0	6	6
83	R:R:C89	R:R:S79	3.44	Yes	No	0	9	6
84	R:R:F163	R:R:L80	3.65	Yes	No	1	4	5
85	R:R:D82	R:R:T86	13.01	No	No	1	4	3
86	R:R:C89	R:R:D82	7.78	Yes	No	1	9	4
87	R:R:R164	R:R:T83	12.94	Yes	No	0	5	3
88	R:R:D85	R:R:S84	7.36	No	No	0	7	5
89	R:R:P87	R:R:T86	3.5	No	No	0	1	3
90	R:R:C89	R:R:T86	3.38	Yes	No	1	9	3
91	R:R:C89	R:R:Q93	7.63	Yes	Yes	1	9	6
92	R:R:C162	R:R:C89	7.28	No	Yes	1	9	9
93	R:R:Q90	R:R:W152	4.38	No	No	0	7	4
94	R:R:I95	R:R:L91	5.71	No	No	0	5	4
95	R:R:C162	R:R:Q93	9.16	No	Yes	1	9	6
96	R:R:F163	R:R:Q93	29.28	Yes	Yes	1	4	6
97	R:R:I95	R:R:N99	5.66	No	Yes	1	5	8
98	R:R:L97	R:R:Y96	3.52	Yes	Yes	1	5	6
99	R:R:R100	R:R:Y96	13.38	Yes	Yes	1	7	6
100	R:R:F163	R:R:Y96	4.13	Yes	Yes	1	4	6
101	R:R:D266	R:R:Y96	12.64	Yes	Yes	1	7	6
102	R:R:L97	R:R:R100	3.64	Yes	Yes	1	5	7
103	R:R:L97	R:R:Y101	3.52	Yes	No	0	5	7
104	R:R:L148	R:R:L97	6.92	No	Yes	0	6	5
105	R:R:L97	R:R:R151	4.86	Yes	Yes	1	5	4
106	R:R:F161	R:R:L97	3.65	No	Yes	1	3	5
107	R:R:F163	R:R:L97	4.87	Yes	Yes	1	4	5
108	R:R:L148	R:R:T98	8.84	No	No	0	6	5
109	R:R:L233	R:R:R100	4.86	No	Yes	0	7	7
110	R:R:R100	R:R:S265	6.59	Yes	No	0	7	8
111	R:R:P176	R:R:Y101	4.17	No	No	0	5	7
112	R:R:H234	R:R:Y101	5.44	Yes	No	0	9	7
113	R:R:L106	R:R:M102	7.07	No	No	0	7	5
114	R:R:M102	R:R:W141	26.76	No	No	0	5	9
115	R:R:M102	R:R:V144	4.56	No	No	0	5	7
116	R:R:F226	R:R:I104	5.02	Yes	No	3	9	8
117	R:R:F230	R:R:I104	15.07	No	No	3	9	8
118	R:R:L140	R:R:S105	7.51	No	No	0	6	5
119	R:R:F226	R:R:V107	7.87	Yes	No	0	9	8
120	R:R:V107	R:R:Y276	5.05	No	Yes	0	8	9
121	R:R:P183	R:R:T108	6.99	No	No	0	9	7
122	R:R:T108	R:R:V187	4.76	No	No	0	7	8
123	R:R:I110	R:R:R114	6.26	No	No	2	8	9
124	R:R:I110	R:R:Y276	3.63	No	Yes	2	8	9
125	R:R:A111	R:R:V187	5.09	No	No	0	9	8
126	R:R:A111	R:R:C190	3.61	No	No	0	9	6
127	R:R:C190	R:R:V112	3.42	No	No	0	6	6
128	R:R:D113	R:R:R128	14.29	Yes	Yes	2	8	7
129	R:R:N222	R:R:R114	7.23	No	No	2	7	9
130	R:R:R114	R:R:Y276	5.14	No	Yes	2	9	9
131	R:R:R119	R:R:Y115	9.26	Yes	Yes	4	6	7
132	R:R:H120	R:R:Y115	8.71	Yes	Yes	4	6	7
133	R:R:F189	R:R:Y115	7.22	No	Yes	4	4	7
134	R:R:C190	R:R:Y115	4.03	No	Yes	0	6	7
135	R:R:K193	R:R:Y115	4.78	No	Yes	4	3	7
136	R:R:R128	R:R:V116	3.92	Yes	No	0	7	5
137	R:R:A117	R:R:R128	5.53	No	Yes	0	8	7
138	R:R:V118	R:R:V194	11.22	No	No	5	8	7
139	R:R:H120	R:R:R119	10.16	Yes	Yes	4	6	6
140	R:R:K193	R:R:R119	4.95	No	Yes	4	3	6
141	R:R:R119	R:R:T196	3.88	Yes	No	0	6	4
142	R:R:A197	R:R:R119	4.15	No	Yes	0	5	6
143	R:R:Q200	R:R:R119	5.84	No	Yes	0	4	6
144	R:R:R131	R:R:S129	5.27	No	No	0	4	6
145	R:R:Q132	R:R:V136	4.3	No	No	0	3	6
146	R:R:F175	R:R:S147	3.96	No	No	0	5	4
147	R:R:F161	R:R:R151	5.34	No	Yes	1	3	4
148	R:R:F175	R:R:R151	7.48	No	Yes	0	5	4
149	R:R:P176	R:R:R151	12.97	No	Yes	0	5	4
150	R:R:I156	R:R:W152	3.52	No	No	0	3	4
151	R:R:L154	R:R:N171	4.12	No	No	0	5	4
152	R:R:E158	R:R:Q157	11.47	No	No	0	2	4
153	R:R:E158	R:R:R167	6.98	No	Yes	0	2	3
154	R:R:G160	R:R:S165	3.71	No	No	0	3	4
155	R:R:R164	R:R:R255	5.33	Yes	Yes	1	5	4
156	R:R:H168	R:R:S165	5.58	No	No	0	3	4
157	R:R:N169	R:R:R167	7.23	No	Yes	0	3	3
158	R:R:R167	R:R:W245	16.99	Yes	No	0	3	1
159	R:R:H168	R:R:M173	3.94	No	Yes	1	3	4
160	R:R:H168	R:R:R240	9.03	No	Yes	1	3	5
161	R:R:N169	R:R:N171	13.62	No	No	0	3	4
162	R:R:F170	R:R:L241	8.53	No	No	0	2	5
163	R:R:L237	R:R:M173	5.65	Yes	Yes	1	6	4
164	R:R:M173	R:R:R240	4.96	Yes	Yes	1	4	5
165	R:R:L241	R:R:M173	8.48	No	Yes	0	5	4
166	R:R:L177	R:R:T238	8.84	No	No	0	4	5
167	R:R:F180	R:R:Y181	5.16	Yes	No	0	8	5
168	R:R:F180	R:R:L184	12.18	Yes	No	3	8	6
169	R:R:F180	R:R:F226	6.43	Yes	Yes	3	8	9
170	R:R:F180	R:R:L231	4.87	Yes	Yes	0	8	5
171	R:R:F180	R:R:H234	24.89	Yes	Yes	0	8	9
172	R:R:T238	R:R:Y181	8.74	No	No	0	5	5
173	R:R:L182	R:R:P183	3.28	No	No	0	5	9
174	R:R:F226	R:R:L184	3.65	Yes	No	3	9	6
175	R:R:F189	R:R:K193	16.13	No	No	4	4	3
176	R:R:L223	R:R:S191	12.01	No	No	0	8	8
177	R:R:V195	R:R:W220	15.94	No	No	0	5	4
178	R:R:L198	R:R:T212	7.37	Yes	No	0	8	6
179	R:R:R201	R:R:T212	7.76	No	No	0	6	6
180	R:R:Q208	R:R:T204	5.67	No	No	0	5	3
181	R:R:D205	R:R:V206	5.84	No	No	0	3	3
182	R:R:A209	R:R:R213	4.15	No	No	0	1	5
183	R:R:R213	R:R:R217	5.33	No	No	0	5	5
184	R:R:M218	R:R:M279	5.78	No	No	0	7	6
185	R:R:N222	R:R:Y276	24.42	No	Yes	2	7	9
186	R:R:L271	R:R:V225	5.96	No	No	0	6	6
187	R:R:F226	R:R:F230	7.5	Yes	No	3	9	9
188	R:R:C229	R:R:N268	9.45	No	No	0	8	9
189	R:R:F230	R:R:N268	15.71	No	No	0	9	9
190	R:R:L231	R:R:P232	3.28	Yes	No	0	5	9
191	R:R:L264	R:R:P232	3.28	No	No	0	7	9
192	R:R:H234	R:R:L233	6.43	Yes	No	0	9	7
193	R:R:L233	R:R:T261	7.37	No	No	0	7	7
194	R:R:H234	R:R:L237	6.43	Yes	Yes	0	9	6
195	R:R:L237	R:R:R240	3.64	Yes	Yes	1	6	5
196	R:R:L258	R:R:R240	4.86	No	Yes	1	5	5
197	R:R:R256	R:R:T253	3.88	No	No	0	2	2
198	R:R:K263	R:R:Y259	9.55	Yes	Yes	0	4	4
199	R:R:K263	R:R:S262	4.59	Yes	No	0	4	6
200	R:R:D266	R:R:S262	4.42	Yes	No	0	7	6
201	R:R:D272	R:R:N268	13.46	No	No	0	9	9
202	R:R:D272	R:R:Y276	8.05	No	Yes	0	9	9
203	R:R:F283	R:R:Y278	16.5	Yes	No	0	8	7
204	R:R:F283	R:R:S287	3.96	Yes	No	0	8	5
205	R:R:C275	R:R:M279	3.24	No	No	0	7	6
206	R:R:S147	R:R:V144	3.23	No	No	0	4	7
207	R:R:S191	R:R:V219	3.23	No	No	0	8	7
208	R:R:V194	R:R:V219	3.21	No	No	0	7	7
209	R:R:V195	R:R:V219	3.21	No	No	0	5	7
210	R:R:T108	R:R:V186	3.17	No	No	0	7	6
211	R:R:C229	R:R:L271	3.17	No	No	0	8	6
212	R:R:A63	R:R:L42	3.15	No	No	0	8	7
213	R:R:A247	R:R:L251	3.15	No	No	0	5	5
214	R:R:T53	R:R:T55	3.14	No	No	0	7	8
215	R:R:C162	R:R:Q90	3.05	No	No	0	9	7
216	R:R:F161	R:R:G94	3.01	No	No	0	3	4
217	R:R:L62	R:R:S103	3	Yes	No	0	9	9
218	R:R:L88	R:R:S79	3	No	No	0	5	6
219	R:R:G159	R:R:R167	3	No	Yes	0	3	3
220	R:R:L198	R:R:V118	2.98	Yes	No	5	8	8
221	R:R:L140	R:R:V136	2.98	No	No	0	6	6
222	R:R:N169	R:R:S172	2.98	No	No	0	3	5
223	R:R:L184	R:R:V188	2.98	No	No	0	6	3
224	R:R:L192	R:R:V188	2.98	No	No	0	2	3
225	R:R:L198	R:R:V194	2.98	Yes	No	5	8	7
226	R:R:L223	R:R:V227	2.98	No	No	0	8	4
227	R:R:L231	R:R:V227	2.98	Yes	No	0	5	4
228	R:R:L231	R:R:V235	2.98	Yes	No	0	5	5
229	R:R:L250	R:R:V243	2.98	No	No	0	1	2
230	R:R:D113	R:R:T55	2.89	Yes	No	0	8	8
231	R:R:Q132	R:R:S129	2.89	No	No	0	3	6
232	R:R:K214	R:R:K281	2.87	No	No	0	8	5
233	R:R:I254	R:R:L250	2.85	No	No	0	4	1
234	R:R:A124	R:R:R128	2.77	No	Yes	0	5	7
235	R:R:A150	R:R:F175	2.77	No	No	0	8	5
236	R:R:A267	R:R:Y26	2.67	No	No	0	4	6
237	R:R:L153	R:R:Q157	2.66	No	No	0	3	4
238	R:R:I254	R:R:R240	2.51	No	Yes	0	4	5
239	R:R:K20	R:R:R81	2.48	No	No	0	2	3
240	R:R:V44	R:R:W43	2.45	No	No	0	6	4
241	R:R:K263	R:R:Y26	2.39	Yes	No	0	4	6
242	R:R:Q208	R:R:R201	2.34	No	No	0	5	6
243	R:R:G155	R:R:G160	2.11	No	No	0	4	3
244	R:R:G159	R:R:G160	2.11	No	No	0	3	3
245	R:R:G179	R:R:P183	2.03	No	No	0	6	9
246	R:R:R48	R:R:W43	2	No	No	0	5	4
247	R:R:P16	R:R:P17	1.95	No	No	0	3	3
248	R:R:P202	R:R:P203	1.95	No	No	0	4	3
249	R:R:G146	R:R:V149	1.84	No	No	0	4	4
250	R:R:G207	R:R:V206	1.84	No	No	0	4	3
251	R:R:G236	R:R:V239	1.84	No	No	0	5	4
252	R:R:C46	R:R:C47	1.82	No	No	0	2	4
253	R:R:A249	R:R:C248	1.81	No	No	0	2	7
254	R:R:P130	R:R:S129	1.78	No	No	0	3	6
255	R:R:C275	R:R:V225	1.71	No	No	0	7	6
256	R:R:C229	R:R:V228	1.71	No	No	0	8	5
257	R:R:G236	R:R:L258	1.71	No	No	0	5	5
258	R:R:A197	R:R:V118	1.7	No	No	0	5	8
259	R:R:C46	R:R:T60	1.69	No	No	0	2	5
260	R:R:C275	R:R:I274	1.64	No	No	0	7	7
261	R:R:A286	R:R:M49	1.61	No	No	0	6	5
262	R:R:A221	R:R:M279	1.61	No	No	0	5	6
263	R:R:S10	R:R:T83	1.6	No	No	0	4	3
264	R:R:S10	R:R:T166	1.6	No	No	0	4	5
265	R:R:S84	R:R:T83	1.6	No	No	0	5	3
266	R:R:C71	R:R:L35	1.59	No	No	0	3	6
267	R:R:C248	R:R:L250	1.59	No	No	0	7	1
268	R:R:A215	R:R:L198	1.58	No	Yes	0	7	8
269	R:R:A65	R:R:D66	1.54	No	Yes	0	8	9
270	R:R:I145	R:R:V149	1.54	No	No	0	4	4
271	R:R:H120	R:R:P121	1.53	Yes	No	0	6	8
272	R:R:I145	R:R:T98	1.52	No	No	0	4	5
273	R:R:L36	R:R:V32	1.49	No	No	0	5	5
274	R:R:P202	R:R:R201	1.44	No	No	0	4	6
275	R:R:K214	R:R:M218	1.44	No	No	0	8	7
276	R:R:Q51	R:R:T53	1.42	No	No	0	5	7
277	R:R:F75	R:R:S92	1.32	No	No	0	6	5
278	R:R:K20	R:R:Y259	1.19	No	Yes	0	2	4
279	R:R:F283	R:R:Q284	1.17	Yes	No	0	8	8
280	R:R:E210	R:R:R213	1.16	No	No	0	4	5
281	R:R:H120	R:R:R123	1.13	Yes	No	0	6	5
282	R:R:N246	R:R:W245	1.13	No	No	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.2178	9	1	0
2	R:R:W15	6.27	4	0	2
3	R:R:L37	6.405	4	0	7
4	R:R:F45	6.286	5	2	6
5	R:R:E54	12.5025	4	2	6
6	R:R:Y58	6.86	6	2	7
7	R:R:L62	5.2675	4	0	9
8	R:R:D66	8.1725	4	0	9
9	R:R:L69	6.08	4	1	7
10	R:R:C89	5.902	5	1	9
11	R:R:Q93	12.95	4	1	6
12	R:R:Y96	8.14	5	1	6
13	R:R:L97	4.42571	7	1	5
14	R:R:N99	6.1975	4	1	8
15	R:R:R100	7.1175	4	1	7
16	R:R:D113	9.6675	4	2	8
17	R:R:Y115	6.8	5	4	7
18	R:R:R119	6.37333	6	4	6
19	R:R:H120	5.3825	4	4	6
20	R:R:R128	8.326	5	2	7
21	R:R:R151	7.6625	4	1	4
22	R:R:F163	16.762	5	1	4
23	R:R:R164	7.685	4	1	5
24	R:R:R167	8.55	4	0	3
25	R:R:M173	5.7575	4	1	4
26	R:R:F180	10.706	5	3	8
27	R:R:L198	3.7275	4	5	8
28	R:R:F226	6.094	5	3	9
29	R:R:L231	3.5275	4	0	5
30	R:R:H234	10.7975	4	0	9
31	R:R:L237	5.195	4	1	6
32	R:R:R240	4.75833	6	1	5
33	R:R:R255	14.18	4	1	4
34	R:R:Y259	7.008	5	0	4
35	R:R:K263	5.5425	4	0	4
36	R:R:D266	7.3175	4	1	7
37	R:R:Y276	8.31333	6	2	9
38	R:R:Y277	6.194	5	2	7
39	R:R:F283	6.7175	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R164	11.9717	8	Yes	Yes	1	0	5
2	L:L:?1	R:R:F163	33.4215	41.88	Yes	Yes	1	0	4
3	L:L:?1	R:R:L237	38.0256	5.06	Yes	Yes	1	0	6
4	L:L:?1	R:R:R240	16.7809	3.55	Yes	Yes	1	0	5
5	L:L:?1	R:R:Y259	31.0142	9.43	Yes	Yes	0	0	4
6	L:L:?1	R:R:S262	18.8752	7.69	Yes	No	0	0	6
7	R:R:H168	R:R:R240	22.7722	9.03	No	Yes	1	3	5
8	R:R:H168	R:R:S165	32.2178	5.58	No	No	0	3	4
9	R:R:G160	R:R:S165	30.2963	3.71	No	No	0	3	4
10	R:R:G159	R:R:G160	26.097	2.11	No	No	0	3	3
11	R:R:G159	R:R:R167	23.9812	3	No	Yes	0	3	3
12	R:R:W15	R:R:Y259	13.2995	8.68	Yes	Yes	0	2	4
13	R:R:K263	R:R:S262	10.9624	4.59	Yes	No	0	4	6
14	R:R:D266	R:R:S262	21.2231	4.42	Yes	No	0	7	6
15	R:R:F163	R:R:Y96	19.6686	4.13	Yes	Yes	1	4	6
16	R:R:L69	R:R:Y96	30.1344	7.03	Yes	Yes	1	7	6
17	R:R:C269	R:R:L69	43.0615	6.35	No	Yes	0	8	7
18	R:R:C269	R:R:D66	37.3131	10.89	No	Yes	0	8	9
19	R:R:D66	R:R:L62	36.6816	8.14	Yes	Yes	0	9	9
20	R:R:L62	R:R:Y277	25.1147	5.86	Yes	Yes	0	9	7
21	R:R:F45	R:R:Y277	19.7711	6.19	Yes	Yes	2	6	7
22	R:R:F45	R:R:V44	26.572	3.93	Yes	No	0	6	6
23	R:R:F283	R:R:V44	21.0342	5.24	Yes	No	0	8	6
24	R:R:F283	R:R:Y278	15.3991	16.5	Yes	No	0	8	7
25	R:R:L37	R:R:Y278	11.5831	10.55	Yes	No	0	7	7
26	R:R:D266	R:R:L69	19.8521	4.07	Yes	Yes	1	7	7
27	R:R:H234	R:R:L237	67.237	6.43	Yes	Yes	0	9	6
28	R:R:F180	R:R:H234	100	24.89	Yes	Yes	0	8	9
29	R:R:F180	R:R:F226	69.952	6.43	Yes	Yes	3	8	9
30	R:R:F226	R:R:V107	53.5543	7.87	Yes	No	0	9	8
31	R:R:V107	R:R:Y276	52.7392	5.05	No	Yes	0	8	9
32	R:R:M59	R:R:Y276	25.2982	3.59	No	Yes	2	8	9
33	R:R:F45	R:R:M59	20.9262	6.22	Yes	No	2	6	8
34	R:R:I110	R:R:Y276	39.6125	3.63	No	Yes	2	8	9
35	R:R:I110	R:R:Y58	38.425	4.84	No	Yes	2	8	7
36	R:R:D113	R:R:Y58	13.2887	4.6	Yes	Yes	2	8	7
37	R:R:V136	R:R:Y58	11.8962	7.57	No	Yes	0	6	7
38	R:R:F163	R:R:L97	18.303	4.87	Yes	Yes	1	4	5
39	R:R:L97	R:R:R151	16.4841	4.86	Yes	Yes	1	5	4
40	R:R:F175	R:R:R151	20.8722	7.48	No	Yes	0	5	4
41	R:R:F175	R:R:S147	17.2883	3.96	No	No	0	5	4
42	R:R:S147	R:R:V144	15.4099	3.23	No	No	0	4	7
43	R:R:M102	R:R:V144	13.5208	4.56	No	No	0	5	7
44	R:R:D272	R:R:L62	15.3236	4.07	No	Yes	0	9	9
45	R:R:D272	R:R:Y276	12.641	8.05	No	Yes	0	9	9
46	R:R:F226	R:R:F230	16.8727	7.5	Yes	No	3	9	9
47	R:R:F230	R:R:N268	16.171	15.71	No	No	0	9	9
48	R:R:D272	R:R:N268	10.7411	13.46	No	No	0	9	9
49	R:R:L69	R:R:N99	10.2229	6.87	Yes	Yes	1	7	8
50	R:R:F163	R:R:Q93	28.445	29.28	Yes	Yes	1	4	6
51	R:R:C89	R:R:Q93	12.3981	7.63	Yes	Yes	1	9	6
52	R:R:L97	R:R:Y101	23.544	3.52	Yes	No	0	5	7
53	R:R:H234	R:R:Y101	30.9278	5.44	Yes	No	0	9	7
54	R:R:F180	R:R:L231	62.1094	4.87	Yes	Yes	0	8	5
55	R:R:L231	R:R:V227	56.6471	2.98	Yes	No	0	5	4
56	R:R:L223	R:R:V227	55.2545	2.98	No	No	0	8	4
57	R:R:L223	R:R:S191	53.8511	12.01	No	No	0	8	8
58	R:R:S191	R:R:V219	52.437	3.23	No	No	0	8	7
59	R:R:V194	R:R:V219	48.1136	3.21	No	No	0	7	7
60	R:R:V118	R:R:V194	33.999	11.22	No	No	5	8	7
61	R:R:A197	R:R:V118	33.3459	1.7	No	No	0	5	8
62	R:R:A197	R:R:R119	31.786	4.15	No	Yes	0	5	6
63	R:R:R119	R:R:Y115	18.5783	9.26	Yes	Yes	4	6	7
64	R:R:C190	R:R:Y115	15.4909	4.03	No	Yes	0	6	7
65	R:R:A111	R:R:C190	12.1228	3.61	No	No	0	9	6
66	R:R:A111	R:R:V187	10.4226	5.09	No	No	0	9	8
67	R:R:L237	R:R:M173	15.6312	5.65	Yes	Yes	1	6	4
68	R:R:L198	R:R:V194	12.6572	2.98	Yes	No	5	8	7
69	R:R:L198	R:R:T212	10.2985	7.37	Yes	No	0	8	6
70	R:R:C229	R:R:N268	19.5444	9.45	No	No	0	8	9
71	R:R:C229	R:R:L271	16.0576	3.17	No	No	0	8	6
72	R:R:L271	R:R:V225	14.2981	5.96	No	No	0	6	6
73	R:R:C275	R:R:V225	12.5277	1.71	No	No	0	7	6
74	R:R:L237	R:R:R240	17.1749	3.64	Yes	Yes	1	6	5
75	R:R:H168	R:R:M173	11.3564	3.94	No	Yes	1	3	4
76	R:R:L97	R:R:Y96	11.2161	3.52	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
I:I:?1	R:R:R164	4.47	1	No	Yes	0	5	2	1
I:I:?1	R:R:R255	15.63	1	No	Yes	0	4	2	1
L:L:?1	R:R:L80	15.19	1	Yes	No	0	5	0	1
L:L:?1	R:R:F163	41.88	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R164	8	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L237	5.06	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R240	3.55	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R255	15.11	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L258	4.05	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y259	9.43	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S262	7.69	1	Yes	No	0	6	0	1
R:R:L13	R:R:R255	20.65	0	No	Yes	2	4	2	1
R:R:W15	R:R:Y259	8.68	0	Yes	Yes	2	4	2	1
R:R:F23	R:R:Y259	6.19	0	No	Yes	4	4	2	1
R:R:F163	R:R:L80	3.65	1	Yes	No	4	5	1	1
R:R:R164	R:R:T83	12.94	1	Yes	No	5	3	1	2
R:R:F163	R:R:Q93	29.28	1	Yes	Yes	4	6	1	2
R:R:L97	R:R:Y96	3.52	1	Yes	Yes	5	6	2	2
R:R:F163	R:R:Y96	4.13	1	Yes	Yes	4	6	1	2
R:R:D266	R:R:Y96	12.64	1	Yes	Yes	7	6	2	2
R:R:F163	R:R:L97	4.87	1	Yes	Yes	4	5	1	2
R:R:R164	R:R:R255	5.33	1	Yes	Yes	5	4	1	1
R:R:H168	R:R:M173	3.94	1	No	Yes	3	4	2	2
R:R:H168	R:R:R240	9.03	1	No	Yes	3	5	2	1
R:R:L237	R:R:M173	5.65	1	Yes	Yes	6	4	1	2
R:R:M173	R:R:R240	4.96	1	Yes	Yes	4	5	2	1
R:R:H234	R:R:L237	6.43	0	Yes	Yes	9	6	2	1
R:R:L237	R:R:R240	3.64	1	Yes	Yes	6	5	1	1
R:R:L258	R:R:R240	4.86	1	No	Yes	5	5	1	1
R:R:K263	R:R:Y259	9.55	0	Yes	Yes	4	4	2	1
R:R:K263	R:R:S262	4.59	0	Yes	No	4	6	2	1
R:R:D266	R:R:S262	4.42	1	Yes	No	7	6	2	1
R:R:I254	R:R:R240	2.51	0	No	Yes	4	5	2	1
R:R:G236	R:R:L258	1.71	0	No	No	5	5	2	1
R:R:K20	R:R:Y259	1.19	0	No	Yes	2	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8H8J_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	250
Number of Links	282
Number of Hubs	39
Number of Links mediated by Hubs	143
Number of Communities	5
Number of Nodes involved in Communities	51
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	43390
Length Of Smallest Path	3
Average Path Length	12.5786
Length of Longest Path	29
Minimum Path Strength	1.33
Average Path Strength	7.58993
Maximum Path Strength	35.58
Minimum Path Correlation	0.7
Average Path Correlation	0.917941
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	48.6052
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0331
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process
Gene Ontology	Biological Process	• multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of cell motility • regulation of fibroblast migration • fibroblast migration • regulation of locomotion • ameboidal-type cell migration • regulation of cell migration • cell migration • cell motility • locomotion • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle • organelle • cytoplasm • vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • brush border membrane • cluster of actin-based cell projections • plasma membrane bounded cell projection • brush border • cell projection • apical part of cell • plasma membrane region • apical plasma membrane • cell projection membrane • postsynapse • synapse • nucleus • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • cytokine receptor activity • immune receptor activity • cellular component organization • organelle organization • cellular component organization or biogenesis • cytoskeleton organization • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • regulation of localization • regulation of calcium ion transport • negative regulation of voltage-gated calcium channel activity • negative regulation of ion transmembrane transporter activity • negative regulation of calcium ion transmembrane transporter activity • transport • negative regulation of monoatomic ion transport • monoatomic ion transmembrane transport • negative regulation of biological process • regulation of transmembrane transporter activity • negative regulation of transport • regulation of monoatomic ion transmembrane transport • regulation of voltage-gated calcium channel activity • negative regulation of transmembrane transport • calcium ion transport • metal ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • localization • negative regulation of monoatomic ion transmembrane transport • negative regulation of cellular process • monoatomic ion transport • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of transport • regulation of monoatomic ion transport • negative regulation of transporter activity • negative regulation of molecular function • establishment of localization • negative regulation of calcium ion transport • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • calcium ion transmembrane transport • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	WYB
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WYB
Name	Lodoxamide
Synonyms	Lodoxamide
Identifier
Formula	C11 H6 Cl N3 O6
Molecular Weight	311.635
SMILES
PubChem	44564
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	0
Total Bonds	27
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9HC97
Sequence	>8H8J_nogp_Chain_R N T C G S S D L T W P P A I K L G F Y A Y L G V L L V L G L L L N S L A L W V F C C R M Q Q W T E T R I Y M T N L A V A D L C L L C T L P F V L H S L R D T S D T P L C Q L S Q G I Y L T N R Y M S I S L V T A I A V D R Y V A V R H P L R A R G L R S P R Q A A A V C A V L W V L V I G S L V A R W L L G I Q E G G F C F R S T R H N F N S M A F P L L G F Y L P L A V V V F C S L K V V T A L A Q R P P T D V G Q A E A T R K A A R M V W A N L L V F V V C F L P L H V G L T V R L A V G W N A C A L L E T I R R A L Y I T S K L S D A N C C L D A I C Y Y Y M A K E F Q E A S A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8H8J	A	Orphan	Orphan	GPR35	Homo sapiens	Lodoxamide	Ca	chim(NtGi1L-G13)/β1/γ2	3.2	2023-02-08	doi.org/10.1038/s41421-022-00499-8
	8H8J (No Gprot)	A	Orphan	Orphan	GPR35	Homo sapiens	Lodoxamide	Ca		3.2	2023-02-08	doi.org/10.1038/s41421-022-00499-8

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