psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:A35	S:S:P36	1.87	No	No	0	2	5
2	S:S:L37	S:S:P38	3.28	No	No	0	1	4
3	S:S:G104	S:S:L37	5.13	No	No	0	3	1
4	S:S:P40	S:S:S39	1.78	No	No	0	3	2
5	S:S:D44	S:S:P40	6.44	No	No	0	4	3
6	S:S:A42	S:S:K41	1.61	No	No	0	4	3
7	S:S:K41	S:S:W43	2.32	No	No	0	3	3
8	S:S:W43	S:S:Y280	7.72	No	No	0	3	4
9	S:S:D44	S:S:F97	8.36	No	Yes	11	4	5
10	S:S:D44	S:S:V100	4.38	No	No	11	4	4
11	S:S:I49	S:S:V45	3.07	No	No	0	4	5
12	S:S:L284	S:S:L47	2.77	No	No	0	4	4
13	S:S:C48	S:S:I49	3.27	No	No	0	3	4
14	S:S:C48	S:S:T52	1.69	No	No	0	3	4
15	S:S:C48	S:S:F97	9.78	No	Yes	0	3	5
16	S:S:G51	S:S:S50	1.86	No	No	0	5	5
17	S:S:S50	S:S:T287	7.99	No	No	0	5	6
18	S:S:G51	S:S:V54	1.84	No	Yes	0	5	7
19	S:S:G51	S:S:L93	1.71	No	No	0	5	6
20	S:S:D86	S:S:V54	4.38	Yes	Yes	1	9	7
21	S:S:G90	S:S:V54	1.84	Yes	Yes	0	7	7
22	S:S:S290	S:S:V54	6.46	No	Yes	1	9	7
23	S:S:M291	S:S:V54	1.52	No	Yes	0	5	7
24	S:S:L87	S:S:S55	3	No	No	0	7	6
25	S:S:G90	S:S:S55	1.86	Yes	No	0	7	6
26	S:S:E57	S:S:N58	2.63	Yes	Yes	1	8	9
27	S:S:E57	S:S:P294	9.43	Yes	Yes	1	8	9
28	S:S:E57	S:S:I295	2.73	Yes	No	0	8	5
29	S:S:E57	S:S:F299	3.5	Yes	No	0	8	5
30	S:S:N58	S:S:V61	4.43	Yes	Yes	1	9	9
31	S:S:A83	S:S:N58	1.56	Yes	Yes	1	9	9
32	S:S:D86	S:S:N58	12.12	Yes	Yes	1	9	9
33	S:S:N58	S:S:P294	6.52	Yes	Yes	1	9	9
34	S:S:F299	S:S:L60	2.44	No	No	0	5	7
35	S:S:I65	S:S:V61	1.54	Yes	Yes	0	7	9
36	S:S:A83	S:S:V61	1.7	Yes	Yes	1	9	9
37	S:S:A298	S:S:V61	1.7	No	Yes	0	7	9
38	S:S:A83	S:S:V62	1.7	Yes	No	0	9	7
39	S:S:I64	S:S:V307	1.54	No	No	0	8	8
40	S:S:F76	S:S:I65	2.51	Yes	Yes	0	9	7
41	S:S:I65	S:S:V79	1.54	Yes	Yes	0	7	7
42	S:S:G80	S:S:I65	1.76	No	Yes	0	6	7
43	S:S:G67	S:S:V66	1.84	No	No	0	5	4
44	S:S:P69	S:S:T68	3.5	No	No	0	5	7
45	S:S:A70	S:S:T68	1.68	No	No	0	6	7
46	S:S:P69	S:S:R72	2.88	No	No	0	5	8
47	S:S:F71	S:S:F76	17.15	Yes	Yes	0	8	9
48	S:S:D303	S:S:F71	2.39	No	Yes	0	7	8
49	S:S:F71	S:S:V307	2.62	Yes	No	0	8	8
50	S:S:A73	S:S:P74	1.87	No	No	4	7	5
51	S:S:A73	S:S:M75	1.61	No	Yes	4	7	8
52	S:S:A73	S:S:F76	4.16	No	Yes	4	7	9
53	S:S:P74	S:S:T149	3.5	No	No	4	5	8
54	S:S:P74	S:S:T153	1.75	No	No	4	5	6
55	S:S:F76	S:S:M75	8.71	Yes	Yes	4	9	8
56	S:S:M75	S:S:V79	1.52	Yes	Yes	0	8	7
57	S:S:L157	S:S:L77	2.77	No	No	0	7	4
58	S:S:A129	S:S:L78	3.15	No	No	0	6	8
59	S:S:I130	S:S:L78	7.14	No	No	0	9	8
60	S:S:L157	S:S:L78	2.77	No	No	0	7	8
61	S:S:I130	S:S:V79	1.54	No	Yes	0	9	7
62	S:S:A298	S:S:V79	1.7	No	Yes	0	7	7
63	S:S:A83	S:S:G80	1.95	Yes	No	0	9	6
64	S:S:S126	S:S:S81	4.89	No	No	0	8	9
65	S:S:L157	S:S:S81	3	No	No	0	7	9
66	S:S:S81	S:S:W161	3.71	No	Yes	0	9	9
67	S:S:L82	S:S:S126	6.01	No	No	0	9	8
68	S:S:L127	S:S:L82	2.77	Yes	No	1	8	9
69	S:S:L82	S:S:N293	12.36	No	Yes	1	9	9
70	S:S:V84	S:S:W161	3.68	No	Yes	0	6	9
71	S:S:A122	S:S:A85	1.79	No	No	12	7	8
72	S:S:A85	S:S:W161	3.89	No	Yes	12	8	9
73	S:S:A89	S:S:D86	1.54	Yes	Yes	0	8	9
74	S:S:D86	S:S:S290	10.31	Yes	No	1	9	9
75	S:S:D86	S:S:P294	1.61	Yes	Yes	1	9	9
76	S:S:L88	S:S:V115	2.98	No	No	0	7	4
77	S:S:A119	S:S:L88	1.58	No	No	0	6	7
78	S:S:A89	S:S:G90	1.95	Yes	Yes	0	8	7
79	S:S:A119	S:S:A89	1.79	No	Yes	0	6	8
80	S:S:A89	S:S:F120	2.77	Yes	No	0	8	4
81	S:S:G90	S:S:L93	1.71	Yes	No	0	7	6
82	S:S:G92	S:S:L91	1.71	Yes	No	3	4	4
83	S:S:L91	S:S:L95	4.15	No	Yes	3	4	7
84	S:S:G92	S:S:L95	1.71	Yes	Yes	3	4	7
85	S:S:G92	S:S:L112	1.71	Yes	Yes	3	4	5
86	S:S:G92	S:S:L116	1.71	Yes	No	0	4	5
87	S:S:L112	S:S:L95	6.92	Yes	Yes	3	5	7
88	S:S:H96	S:S:L112	3.86	No	Yes	0	5	5
89	S:S:F97	S:S:V100	2.62	Yes	No	11	5	4
90	S:S:F101	S:S:F97	4.29	No	Yes	0	4	5
91	S:S:A99	S:S:I103	1.62	No	No	3	4	5
92	S:S:A99	S:S:S105	1.71	No	No	3	4	7
93	S:S:A99	S:S:L112	1.58	No	Yes	3	4	5
94	S:S:C102	S:S:F101	9.78	No	No	0	5	4
95	S:S:G104	S:S:I103	3.53	No	No	0	3	5
96	S:S:I103	S:S:S105	3.1	No	No	3	5	7
97	S:S:M108	S:S:S105	6.13	No	No	0	4	7
98	S:S:A106	S:S:E107	4.53	No	No	0	3	1
99	S:S:M108	S:S:V111	1.52	No	No	0	4	4
100	S:S:L110	S:S:V172	2.98	No	No	0	5	5
101	S:S:L110	S:S:P189	1.64	No	Yes	0	5	3
102	S:S:G114	S:S:V113	1.84	No	No	0	5	4
103	S:S:F120	S:S:L116	2.44	No	No	0	4	5
104	S:S:A164	S:S:M118	1.61	No	No	0	8	4
105	S:S:L165	S:S:M118	4.24	No	No	0	4	4
106	S:S:G168	S:S:M118	1.75	No	No	0	6	4
107	S:S:F120	S:S:W260	7.02	No	Yes	0	4	8
108	S:S:A164	S:S:T121	3.36	No	No	0	8	6
109	S:S:A122	S:S:W161	7.78	No	Yes	12	7	9
110	S:S:I124	S:S:S123	1.55	Yes	No	0	8	9
111	S:S:G125	S:S:I124	1.76	No	Yes	0	5	8
112	S:S:I124	S:S:V205	1.54	Yes	No	0	8	8
113	S:S:F256	S:S:I124	3.77	Yes	Yes	1	9	8
114	S:S:I124	S:S:W260	2.35	Yes	Yes	1	8	8
115	S:S:G125	S:S:V160	3.68	No	No	0	5	6
116	S:S:F256	S:S:L127	2.44	Yes	Yes	1	9	8
117	S:S:L127	S:S:N293	4.12	Yes	Yes	1	8	9
118	S:S:L127	S:S:Y297	3.52	Yes	Yes	1	8	9
119	S:S:L128	S:S:M209	5.65	No	No	0	7	8
120	S:S:I130	S:S:Y297	4.84	No	Yes	0	9	9
121	S:S:M209	S:S:T131	4.52	No	No	0	8	8
122	S:S:T131	S:S:Y213	4.99	No	Yes	0	8	9
123	S:S:M156	S:S:V132	1.52	No	No	0	5	6
124	S:S:L212	S:S:V132	2.98	No	No	0	6	6
125	S:S:I216	S:S:R134	6.26	No	No	0	9	9
126	S:S:L136	S:S:Y135	3.52	No	Yes	0	5	8
127	S:S:Y135	S:S:Y139	8.94	Yes	No	0	8	6
128	S:S:L212	S:S:Y135	5.86	No	Yes	0	6	8
129	S:S:Q215	S:S:Y135	2.25	Yes	Yes	10	6	8
130	R:R:Q215	S:S:Y135	12.4	Yes	Yes	10	6	8
131	S:S:L136	S:S:R152	2.43	No	No	0	5	7
132	S:S:L138	S:S:S137	3	No	No	0	8	8
133	S:S:I216	S:S:L138	2.85	No	No	0	9	8
134	S:S:T143	S:S:Y139	6.24	No	No	0	5	6
135	R:R:I219	S:S:Y139	2.42	No	No	0	6	6
136	S:S:N140	S:S:S146	8.94	No	No	0	5	4
137	S:S:E147	S:S:Y145	13.47	No	No	0	5	4
138	R:R:R222	S:S:Y145	5.14	No	No	0	5	4
139	S:S:E147	S:S:T148	5.64	No	No	0	5	6
140	S:S:T148	S:S:T151	7.85	No	No	0	6	4
141	S:S:T149	S:S:V150	1.59	No	No	0	8	3
142	S:S:T149	S:S:T153	1.57	No	No	4	8	6
143	S:S:T151	S:S:V150	1.59	No	No	0	4	3
144	S:S:V150	S:S:Y154	5.05	No	No	0	3	1
145	S:S:M156	S:S:R152	3.72	No	No	0	5	7
146	R:R:R218	S:S:R152	3.2	No	No	0	4	7
147	S:S:M156	S:S:V155	3.04	No	No	0	5	3
148	S:S:G162	S:S:G163	2.11	No	No	0	3	3
149	S:S:G166	S:S:L165	1.71	No	No	0	2	4
150	S:S:G166	S:S:L169	3.42	No	No	0	2	3
151	S:S:H194	S:S:L167	2.57	Yes	No	2	7	6
152	S:S:L167	S:S:L198	2.77	No	No	2	6	6
153	S:S:G168	S:S:P171	4.06	No	Yes	0	6	5
154	S:S:L169	S:S:L173	2.77	No	No	0	3	4
155	S:S:L170	S:S:P171	1.64	No	Yes	2	4	5
156	S:S:H194	S:S:L170	2.57	Yes	No	2	7	4
157	S:S:L190	S:S:P171	1.64	Yes	Yes	2	3	5
158	S:S:H194	S:S:P171	13.73	Yes	Yes	2	7	5
159	S:S:A174	S:S:L173	3.15	No	No	0	4	4
160	S:S:A174	S:S:W175	2.59	No	Yes	0	4	4
161	S:S:S191	S:S:W175	8.65	No	Yes	2	6	4
162	S:S:N193	S:S:W175	5.65	No	Yes	2	3	4
163	S:S:H194	S:S:W175	4.23	Yes	Yes	2	7	4
164	S:S:C177	S:S:T182	3.38	No	No	0	5	4
165	S:S:C177	S:S:C184	7.28	No	No	9	5	9
166	S:S:C177	S:S:P189	3.77	No	Yes	9	5	3
167	S:S:L178	S:S:Y188	2.34	No	No	0	3	5
168	S:S:D179	S:S:G180	5.03	No	No	0	1	3
169	S:S:D179	S:S:L181	2.71	No	No	0	1	2
170	S:S:S191	S:S:T182	4.8	No	No	0	6	4
171	S:S:G185	S:S:T183	1.82	No	No	0	5	3
172	S:S:C184	S:S:Y188	2.69	No	No	9	9	5
173	S:S:C184	S:S:P189	1.88	No	Yes	9	9	3
174	S:S:G185	S:S:V186	1.84	No	Yes	0	5	4
175	S:S:V186	S:S:V187	1.6	Yes	No	0	4	5
176	S:S:L195	S:S:V186	2.98	No	Yes	0	5	4
177	S:S:T279	S:S:V186	1.59	No	Yes	0	4	4
178	S:S:L190	S:S:V187	4.47	Yes	No	0	3	5
179	S:S:P189	S:S:Y188	6.95	Yes	No	9	3	5
180	S:S:H194	S:S:L190	2.57	Yes	Yes	2	7	3
181	S:S:L190	S:S:L195	4.15	Yes	No	0	3	5
182	S:S:N193	S:S:S191	5.96	No	No	2	3	6
183	S:S:K192	S:S:V196	3.04	No	No	0	4	3
184	S:S:H194	S:S:L198	9	Yes	No	2	7	6
185	S:S:C267	S:S:L195	6.35	No	No	0	6	5
186	S:S:I200	S:S:V196	1.54	No	No	0	4	3
187	R:R:L269	S:S:V196	5.96	No	No	0	4	3
188	S:S:A199	S:S:T264	1.68	No	No	0	4	5
189	S:S:A199	S:S:L268	1.58	No	No	0	4	5
190	R:R:F203	S:S:I200	13.82	Yes	No	0	4	4
191	S:S:F202	S:S:F203	6.43	Yes	Yes	1	8	4
192	S:S:F202	S:S:W260	3.01	Yes	Yes	1	8	8
193	S:S:F202	S:S:L261	2.44	Yes	Yes	1	8	4
194	S:S:F202	S:S:T264	11.67	Yes	No	1	8	5
195	S:S:F203	S:S:L261	2.44	Yes	Yes	1	4	4
196	S:S:F203	S:S:T264	2.59	Yes	No	1	4	5
197	R:R:I200	S:S:F203	15.07	No	Yes	1	4	4
198	R:R:M204	S:S:F203	2.49	No	Yes	0	4	4
199	R:R:F203	S:S:M204	2.49	Yes	No	0	4	4
200	R:R:F206	S:S:M204	7.46	Yes	No	0	6	4
201	S:S:F206	S:S:G207	1.51	Yes	No	0	6	4
202	S:S:F206	S:S:F256	4.29	Yes	Yes	0	6	9
203	S:S:A257	S:S:F206	2.77	No	Yes	0	5	6
204	R:R:M204	S:S:F206	4.98	No	Yes	0	4	6
205	S:S:G207	S:S:L210	1.71	No	No	0	4	4
206	R:R:I208	S:S:G207	1.76	No	No	0	5	4
207	R:R:Q211	S:S:I208	4.12	Yes	No	0	2	5
208	S:S:Q211	S:S:Q215	8.96	Yes	Yes	0	2	6
209	R:R:I208	S:S:Q211	4.12	No	Yes	0	5	2
210	R:R:Q211	S:S:Q211	10.24	Yes	Yes	0	2	2
211	R:R:L212	S:S:Q211	6.65	No	Yes	0	6	2
212	R:R:Q211	S:S:L212	2.66	Yes	No	0	2	6
213	S:S:I216	S:S:Y213	2.42	No	Yes	0	9	9
214	S:S:L249	S:S:Y213	8.21	Yes	Yes	0	7	9
215	S:S:V252	S:S:Y213	6.31	No	Yes	0	7	9
216	S:S:Y213	S:S:Y297	3.97	Yes	Yes	0	9	9
217	R:R:Y135	S:S:Q215	11.27	Yes	Yes	10	8	6
218	R:R:Q215	S:S:Q215	2.56	Yes	Yes	10	6	6
219	S:S:C217	S:S:L249	1.59	No	Yes	0	6	7
220	R:R:R152	S:S:R218	6.4	No	No	0	7	4
221	R:R:Y139	S:S:I219	2.42	No	No	0	6	6
222	S:S:A241	S:S:R243	5.53	No	No	0	6	5
223	S:S:I246	S:S:T242	3.04	No	No	0	7	7
224	S:S:G245	S:S:K244	1.74	No	No	13	8	8
225	S:S:K244	S:S:T248	3	No	No	13	8	8
226	S:S:G245	S:S:T248	3.64	No	No	13	8	8
227	S:S:A250	S:S:I246	1.62	No	No	0	5	7
228	S:S:L249	S:S:T248	5.9	Yes	No	0	7	8
229	S:S:I296	S:S:V252	4.61	No	No	0	8	7
230	S:S:G254	S:S:L253	1.71	No	No	0	4	7
231	S:S:F256	S:S:W260	4.01	Yes	Yes	1	9	8
232	S:S:A257	S:S:L261	1.58	No	Yes	0	5	4
233	S:S:C259	S:S:P285	1.88	No	No	0	8	7
234	S:S:C259	S:S:N289	6.3	No	No	0	8	9
235	S:S:F263	S:S:W260	2	No	Yes	0	6	8
236	S:S:A286	S:S:W260	6.48	No	Yes	0	6	8
237	S:S:N289	S:S:W260	5.65	No	Yes	0	9	8
238	S:S:L261	S:S:P262	1.64	Yes	No	0	4	9
239	S:S:P262	S:S:T282	3.5	No	No	0	9	8
240	S:S:F263	S:S:L283	2.44	No	No	0	6	4
241	S:S:G270	S:S:Y266	2.9	No	Yes	0	3	3
242	S:S:S274	S:S:Y266	7.63	No	Yes	0	3	3
243	S:S:Y266	S:S:Y278	8.94	Yes	No	0	3	3
244	S:S:T279	S:S:Y266	4.99	No	Yes	0	4	3
245	S:S:T282	S:S:Y266	4.99	No	Yes	0	8	3
246	R:R:V196	S:S:L268	4.47	Yes	No	1	3	5
247	R:R:I200	S:S:L268	2.85	No	No	1	4	5
248	R:R:N193	S:S:L269	2.75	No	No	0	3	4
249	R:R:V196	S:S:L269	4.47	Yes	No	0	3	4
250	S:S:A272	S:S:D271	1.54	No	No	14	3	4
251	S:S:D271	S:S:H273	3.78	No	No	14	4	3
252	S:S:A272	S:S:H273	2.93	No	No	14	3	3
253	S:S:P275	S:S:S274	5.34	No	No	0	3	3
254	S:S:P275	S:S:P276	1.95	No	No	0	3	2
255	S:S:L277	S:S:P275	1.64	No	No	0	4	3
256	S:S:L277	S:S:Y278	4.69	No	No	0	4	3
257	S:S:T279	S:S:Y280	3.75	No	No	0	4	4
258	S:S:L284	S:S:P285	1.64	No	No	0	4	7
259	S:S:L284	S:S:Y288	3.52	No	No	0	4	4
260	S:S:M291	S:S:Y288	3.59	No	No	0	5	4
261	S:S:I292	S:S:M291	7.29	No	No	0	5	5
262	S:S:N293	S:S:P294	8.15	Yes	Yes	1	9	9
263	S:S:N293	S:S:Y297	2.33	Yes	Yes	1	9	9
264	S:S:D303	S:S:N301	14.81	No	No	0	7	8
265	S:S:N301	S:S:V304	4.43	No	No	0	8	8
266	S:S:Q302	S:S:Q305	2.56	No	No	0	5	8
267	S:S:K306	S:S:Q302	10.85	No	No	0	5	5
268	S:S:D303	S:S:K306	5.53	No	No	0	7	5
269	S:S:C312	S:S:W309	5.22	No	No	0	5	4
270	R:R:A35	R:R:P36	1.87	No	No	0	2	5
271	R:R:L37	R:R:P38	3.28	No	No	0	1	4
272	R:R:G104	R:R:L37	5.13	No	No	0	3	1
273	R:R:P40	R:R:S39	1.78	No	No	0	3	2
274	R:R:D44	R:R:P40	6.44	Yes	No	0	4	3
275	R:R:K41	R:R:W43	4.64	No	No	0	3	3
276	R:R:A42	R:R:V45	1.7	No	No	0	4	5
277	R:R:L277	R:R:W43	3.42	No	No	0	4	3
278	R:R:W43	R:R:Y280	5.79	No	No	0	3	4
279	R:R:D44	R:R:F97	15.52	Yes	No	0	4	5
280	R:R:D44	R:R:Y280	2.3	Yes	No	0	4	4
281	R:R:I49	R:R:V45	1.54	No	No	0	4	5
282	R:R:L284	R:R:L47	2.77	Yes	No	0	4	4
283	R:R:C48	R:R:T52	1.69	No	No	0	3	4
284	R:R:C48	R:R:F97	5.59	No	No	0	3	5
285	R:R:G51	R:R:S50	1.86	No	No	0	5	5
286	R:R:S50	R:R:T287	7.99	No	No	0	5	6
287	R:R:G51	R:R:V54	1.84	No	Yes	0	5	7
288	R:R:G51	R:R:L93	1.71	No	No	0	5	6
289	R:R:C56	R:R:T52	1.69	No	No	0	4	4
290	R:R:D86	R:R:V54	4.38	Yes	Yes	5	9	7
291	R:R:G90	R:R:V54	1.84	No	Yes	0	7	7
292	R:R:S290	R:R:V54	6.46	No	Yes	5	9	7
293	R:R:M291	R:R:V54	1.52	No	Yes	0	5	7
294	R:R:L87	R:R:S55	3	No	No	0	7	6
295	R:R:G90	R:R:S55	1.86	No	No	0	7	6
296	R:R:E57	R:R:P294	9.43	No	Yes	0	8	9
297	R:R:N58	R:R:V61	4.43	Yes	Yes	5	9	9
298	R:R:A83	R:R:N58	1.56	No	Yes	0	9	9
299	R:R:D86	R:R:N58	14.81	Yes	Yes	5	9	9
300	R:R:L87	R:R:N58	2.75	No	Yes	0	7	9
301	R:R:N58	R:R:P294	6.52	Yes	Yes	5	9	9
302	R:R:F299	R:R:L60	2.44	No	No	0	5	7
303	R:R:I65	R:R:V61	1.54	No	Yes	0	7	9
304	R:R:P294	R:R:V61	1.77	Yes	Yes	5	9	9
305	R:R:A298	R:R:V61	1.7	No	Yes	0	7	9
306	R:R:A83	R:R:V62	3.39	No	No	0	9	7
307	R:R:I64	R:R:V307	1.54	No	No	0	8	8
308	R:R:I64	R:R:L308	2.85	No	No	0	8	5
309	R:R:G80	R:R:I65	1.76	No	No	0	6	7
310	R:R:G67	R:R:V66	1.84	No	No	0	5	4
311	R:R:P69	R:R:T68	3.5	No	No	0	5	7
312	R:R:A70	R:R:T68	1.68	No	No	0	6	7
313	R:R:P69	R:R:R72	2.88	No	No	0	5	8
314	R:R:F71	R:R:F76	10.72	Yes	Yes	8	8	9
315	R:R:D303	R:R:F71	10.75	Yes	Yes	8	7	8
316	R:R:F71	R:R:V307	5.24	Yes	No	0	8	8
317	R:R:A73	R:R:P74	1.87	No	No	0	7	5
318	R:R:A73	R:R:F76	5.55	No	Yes	0	7	9
319	R:R:P74	R:R:T153	1.75	No	No	0	5	6
320	R:R:F76	R:R:M75	3.73	Yes	No	0	9	8
321	R:R:M75	R:R:V79	1.52	No	No	0	8	7
322	R:R:D133	R:R:M75	4.16	No	No	0	9	8
323	R:R:F76	R:R:N301	2.42	Yes	No	8	9	8
324	R:R:D303	R:R:F76	2.39	Yes	Yes	8	7	9
325	R:R:A129	R:R:L78	3.15	No	Yes	0	6	8
326	R:R:I130	R:R:L78	5.71	No	Yes	0	9	8
327	R:R:D133	R:R:L78	2.71	No	Yes	0	9	8
328	R:R:L78	R:R:T153	2.95	Yes	No	0	8	6
329	R:R:L157	R:R:L78	2.77	No	Yes	0	7	8
330	R:R:I130	R:R:V79	1.54	No	No	0	9	7
331	R:R:A298	R:R:V79	1.7	No	No	0	7	7
332	R:R:A83	R:R:G80	1.95	No	No	0	9	6
333	R:R:S126	R:R:S81	4.89	No	No	0	8	9
334	R:R:L157	R:R:S81	3	No	No	0	7	9
335	R:R:L82	R:R:S126	9.01	No	No	0	9	8
336	R:R:L82	R:R:N293	12.36	No	No	0	9	9
337	R:R:A122	R:R:A85	1.79	No	No	0	7	8
338	R:R:A89	R:R:D86	1.54	Yes	Yes	0	8	9
339	R:R:D86	R:R:S290	10.31	Yes	No	5	9	9
340	R:R:D86	R:R:P294	3.22	Yes	Yes	5	9	9
341	R:R:A119	R:R:L88	3.15	No	No	0	6	7
342	R:R:A89	R:R:G90	1.95	Yes	No	0	8	7
343	R:R:A119	R:R:A89	1.79	No	Yes	0	6	8
344	R:R:A89	R:R:F120	2.77	Yes	No	0	8	4
345	R:R:G92	R:R:L91	1.71	No	No	15	4	4
346	R:R:L91	R:R:L95	5.54	No	Yes	15	4	7
347	R:R:G92	R:R:L95	1.71	No	Yes	15	4	7
348	R:R:G92	R:R:L116	1.71	No	No	0	4	5
349	R:R:L116	R:R:L93	2.77	No	No	0	5	6
350	R:R:L112	R:R:L95	5.54	Yes	Yes	0	5	7
351	R:R:H96	R:R:L112	5.14	No	Yes	0	5	5
352	R:R:F101	R:R:F97	3.22	No	No	0	4	5
353	R:R:A99	R:R:S105	1.71	No	No	0	4	7
354	R:R:A99	R:R:L112	1.58	No	Yes	0	4	5
355	R:R:C102	R:R:F101	6.98	No	No	0	5	4
356	R:R:C102	R:R:I103	1.64	No	No	0	5	5
357	R:R:G104	R:R:I103	1.76	No	No	0	3	5
358	R:R:I103	R:R:S105	3.1	No	No	0	5	7
359	R:R:M108	R:R:S105	6.13	No	No	0	4	7
360	R:R:A106	R:R:E107	3.02	No	No	0	3	1
361	R:R:L110	R:R:L173	2.77	No	No	0	5	4
362	R:R:L110	R:R:P189	1.64	No	Yes	0	5	3
363	R:R:L173	R:R:V111	2.98	No	No	0	4	4
364	R:R:G114	R:R:V113	1.84	No	No	0	5	4
365	R:R:G114	R:R:L169	1.71	No	No	0	5	3
366	R:R:G114	R:R:V172	5.52	No	No	0	5	5
367	R:R:F120	R:R:L116	2.44	No	No	0	4	5
368	R:R:A164	R:R:M118	1.61	No	No	0	8	4
369	R:R:L165	R:R:M118	5.65	No	No	0	4	4
370	R:R:L169	R:R:M118	4.24	No	No	0	3	4
371	R:R:F120	R:R:W260	7.02	No	Yes	0	4	8
372	R:R:A164	R:R:T121	1.68	No	No	0	8	6
373	R:R:A122	R:R:W161	6.48	No	No	0	7	9
374	R:R:A122	R:R:A164	1.79	No	No	0	7	8
375	R:R:F202	R:R:I124	2.51	Yes	No	0	8	8
376	R:R:I124	R:R:V205	4.61	No	No	0	8	8
377	R:R:F256	R:R:I124	3.77	No	No	0	9	8
378	R:R:G125	R:R:V160	1.84	No	No	0	5	6
379	R:R:L127	R:R:M209	2.83	No	Yes	0	8	8
380	R:R:F256	R:R:L127	2.44	No	No	0	9	8
381	R:R:L127	R:R:Y297	3.52	No	Yes	0	8	9
382	R:R:I208	R:R:L128	2.85	No	No	0	5	7
383	R:R:L128	R:R:M209	7.07	No	Yes	0	7	8
384	R:R:A129	R:R:V160	1.7	No	No	0	6	6
385	R:R:I130	R:R:Y297	2.42	No	Yes	0	9	9
386	R:R:M209	R:R:T131	3.01	Yes	No	0	8	8
387	R:R:T131	R:R:Y213	3.75	No	Yes	0	8	9
388	R:R:D133	R:R:Y144	3.45	No	Yes	0	9	8
389	R:R:I216	R:R:R134	5.01	No	No	0	9	9
390	R:R:L136	R:R:Y135	2.34	No	Yes	0	5	8
391	R:R:Y135	R:R:Y139	2.98	Yes	No	0	8	6
392	R:R:L212	R:R:Y135	5.86	No	Yes	0	6	8
393	R:R:Q215	R:R:Y135	2.25	Yes	Yes	10	6	8
394	R:R:S137	R:R:Y144	17.8	No	Yes	0	8	8
395	R:R:N140	R:R:Y139	6.98	No	No	0	5	6
396	R:R:N140	R:R:T143	8.77	No	No	0	5	5
397	R:R:Y144	R:R:Y145	13.9	Yes	No	0	8	4
398	R:R:T149	R:R:Y144	2.5	No	Yes	0	8	8
399	R:R:S146	R:R:T148	1.6	No	No	0	4	6
400	R:R:E147	R:R:T148	2.82	No	No	0	5	6
401	R:R:E147	R:R:T151	2.82	No	No	0	5	4
402	R:R:T149	R:R:V150	1.59	No	No	0	8	3
403	R:R:T149	R:R:T153	1.57	No	No	0	8	6
404	R:R:V150	R:R:Y154	3.79	No	No	0	3	1
405	R:R:M156	R:R:R152	3.72	No	No	0	5	7
406	R:R:L157	R:R:W161	2.28	No	No	0	7	9
407	R:R:G162	R:R:G163	2.11	No	No	0	3	3
408	R:R:G162	R:R:L165	1.71	No	No	0	3	4
409	R:R:G166	R:R:L165	1.71	No	No	0	2	4
410	R:R:L167	R:R:L198	2.77	No	No	0	6	6
411	R:R:G168	R:R:P171	4.06	No	No	0	6	5
412	R:R:L170	R:R:P171	6.57	No	No	0	4	5
413	R:R:H194	R:R:P171	12.2	No	No	0	7	5
414	R:R:N193	R:R:W175	7.91	No	No	0	3	4
415	R:R:D179	R:R:N176	4.04	No	No	0	1	5
416	R:R:C177	R:R:T182	3.38	No	No	6	5	4
417	R:R:C177	R:R:C184	7.28	No	No	6	5	9
418	R:R:C177	R:R:P189	1.88	No	Yes	6	5	3
419	R:R:L178	R:R:Y188	5.86	No	No	6	3	5
420	R:R:L178	R:R:P189	3.28	No	Yes	6	3	3
421	R:R:D179	R:R:G180	3.35	No	No	0	1	3
422	R:R:D179	R:R:T182	7.23	No	No	0	1	4
423	R:R:C184	R:R:T182	1.69	No	No	6	9	4
424	R:R:V186	R:R:Y266	2.52	No	Yes	16	4	3
425	R:R:T279	R:R:V186	4.76	No	No	16	4	4
426	R:R:L190	R:R:V187	8.94	No	No	0	3	5
427	R:R:F263	R:R:V187	2.62	No	No	0	6	5
428	R:R:P189	R:R:Y188	6.95	Yes	No	6	3	5
429	R:R:L190	R:R:L195	5.54	No	No	0	3	5
430	R:R:N193	R:R:S191	5.96	No	No	0	3	6
431	R:R:K192	R:R:V196	3.04	No	Yes	0	4	3
432	R:R:H194	R:R:L198	3.86	No	No	0	7	6
433	R:R:C267	R:R:L195	6.35	No	No	0	6	5
434	R:R:I200	R:R:V196	3.07	No	Yes	1	4	3
435	R:R:A199	R:R:C267	3.61	No	No	17	4	6
436	R:R:A199	R:R:L268	1.58	No	No	17	4	5
437	R:R:F202	R:R:F203	6.43	Yes	Yes	7	8	4
438	R:R:F202	R:R:W260	2	Yes	Yes	0	8	8
439	R:R:F202	R:R:L261	3.65	Yes	Yes	7	8	4
440	R:R:F202	R:R:T264	11.67	Yes	Yes	7	8	5
441	R:R:F203	R:R:L261	2.44	Yes	Yes	7	4	4
442	R:R:F203	R:R:T264	3.89	Yes	Yes	7	4	5
443	R:R:M209	R:R:V205	1.52	Yes	No	0	8	8
444	R:R:F206	R:R:G207	1.51	Yes	No	0	6	4
445	R:R:F206	R:R:F256	5.36	Yes	No	0	6	9
446	R:R:A257	R:R:F206	2.77	No	Yes	0	5	6
447	R:R:G207	R:R:L210	1.71	No	No	0	4	4
448	R:R:Q211	R:R:Q215	11.52	Yes	Yes	0	2	6
449	R:R:I216	R:R:Y213	3.63	No	Yes	0	9	9
450	R:R:L249	R:R:Y213	2.34	No	Yes	0	7	9
451	R:R:V252	R:R:Y213	5.05	No	Yes	0	7	9
452	R:R:Y213	R:R:Y297	4.96	Yes	Yes	0	9	9
453	R:R:I216	R:R:V220	1.54	No	No	0	9	8
454	R:R:C217	R:R:L249	6.35	No	No	0	6	7
455	R:R:I219	R:R:V220	1.54	No	No	0	6	8
456	R:R:C221	R:R:T242	1.69	No	No	0	6	7
457	R:R:A224	R:R:T242	1.68	No	No	0	5	7
458	R:R:A241	R:R:T242	1.68	No	No	0	6	7
459	R:R:G245	R:R:K244	1.74	No	No	0	8	8
460	R:R:T248	R:R:V252	1.59	No	No	0	8	7
461	R:R:I296	R:R:V252	3.07	Yes	No	0	8	7
462	R:R:G254	R:R:L253	1.71	No	No	0	4	7
463	R:R:A257	R:R:G254	1.95	No	No	0	5	4
464	R:R:A255	R:R:I296	1.62	No	Yes	0	6	8
465	R:R:C259	R:R:P285	1.88	No	No	0	8	7
466	R:R:C259	R:R:N289	6.3	No	No	0	8	9
467	R:R:A286	R:R:W260	5.19	No	Yes	0	6	8
468	R:R:N289	R:R:W260	5.65	No	Yes	0	9	8
469	R:R:L261	R:R:P262	1.64	Yes	No	0	4	9
470	R:R:L261	R:R:T264	2.95	Yes	Yes	7	4	5
471	R:R:L261	R:R:V265	2.98	Yes	No	7	4	6
472	R:R:P262	R:R:T282	5.25	No	No	0	9	8
473	R:R:P262	R:R:P285	5.84	No	No	0	9	7
474	R:R:F263	R:R:T282	5.19	No	No	0	6	8
475	R:R:F263	R:R:L283	4.87	No	No	0	6	4
476	R:R:T264	R:R:V265	1.59	Yes	No	7	5	6
477	R:R:S274	R:R:Y266	5.09	No	Yes	0	3	3
478	R:R:Y266	R:R:Y278	4.96	Yes	No	0	3	3
479	R:R:T279	R:R:Y266	6.24	No	Yes	16	4	3
480	R:R:C267	R:R:L268	3.17	No	No	17	6	5
481	R:R:D271	R:R:G270	1.68	No	No	0	4	3
482	R:R:D271	R:R:H273	8.82	No	No	0	4	3
483	R:R:A272	R:R:H273	2.93	No	No	0	3	3
484	R:R:P275	R:R:S274	5.34	No	No	0	3	3
485	R:R:P275	R:R:P276	1.95	No	No	0	3	2
486	R:R:L284	R:R:P285	1.64	Yes	No	0	4	7
487	R:R:L284	R:R:Y288	4.69	Yes	No	0	4	4
488	R:R:N293	R:R:P294	4.89	No	Yes	0	9	9
489	R:R:I296	R:R:Y297	3.63	Yes	Yes	0	8	9
490	R:R:I296	R:R:R300	2.51	Yes	No	0	8	7
491	R:R:F299	R:R:L308	8.53	No	No	0	5	5
492	R:R:D303	R:R:N301	12.12	Yes	No	8	7	8
493	R:R:N301	R:R:V304	8.87	No	No	8	8	8
494	R:R:D303	R:R:V304	2.92	Yes	No	8	7	8
495	R:R:D303	R:R:K306	2.77	Yes	No	0	7	5
496	R:R:L308	R:R:V304	2.98	No	No	0	5	8
497	R:R:C312	R:R:W309	2.61	No	No	0	5	4
498	R:R:C312	R:R:V311	1.71	No	No	0	5	5
499	S:S:G67	S:S:R72	1.5	No	No	0	5	8
500	R:R:G67	R:R:R72	1.5	No	No	0	5	8
501	S:S:L95	S:S:V94	1.49	Yes	No	0	7	6
502	S:S:L110	S:S:V113	1.49	No	No	0	5	4
503	S:S:L167	S:S:V197	1.49	No	No	0	6	5
504	S:S:L249	S:S:V220	1.49	Yes	No	0	7	8
505	S:S:L308	S:S:V304	1.49	No	No	0	5	8
506	R:R:L284	R:R:V46	1.49	Yes	No	0	4	4
507	R:R:L88	R:R:V115	1.49	No	No	0	7	4
508	R:R:L95	R:R:V94	1.49	Yes	No	0	7	6
509	R:R:L112	R:R:V115	1.49	Yes	No	0	5	4
510	R:R:L169	R:R:V115	1.49	No	No	0	3	4
511	R:R:N293	R:R:S123	1.49	No	No	0	9	9
512	R:R:L138	R:R:V220	1.49	No	No	0	8	8
513	R:R:L173	R:R:V172	1.49	No	No	0	4	5
514	S:S:L53	S:S:T52	1.47	No	No	0	4	4
515	R:R:L142	R:R:T143	1.47	No	No	0	7	5
516	R:R:D44	R:R:V100	1.46	Yes	No	0	4	4
517	R:R:I292	R:R:M291	1.46	No	No	0	5	5
518	R:R:G270	R:R:Y266	1.45	No	Yes	0	3	3
519	S:S:I219	S:S:L142	1.43	No	No	0	6	7
520	R:R:I49	R:R:L53	1.43	No	No	0	4	4
521	S:S:G162	S:S:W161	1.41	No	Yes	0	3	9
522	R:R:L53	R:R:M291	1.41	No	No	0	4	5
523	S:S:A70	S:S:F71	1.39	No	Yes	0	6	8
524	S:S:D133	S:S:M75	1.39	No	Yes	0	9	8
525	R:R:A70	R:R:F71	1.39	No	Yes	0	6	8
526	S:S:L210	S:S:L253	1.38	No	No	0	4	7
527	R:R:E57	R:R:I295	1.37	No	No	0	8	5
528	R:R:K306	R:R:Q302	1.36	No	No	0	5	5
529	S:S:E107	S:S:M108	1.35	No	No	0	1	4
530	R:R:E107	R:R:M108	1.35	No	No	0	1	4
531	R:R:A174	R:R:W175	1.3	No	No	0	4	4
532	R:R:H194	R:R:L190	1.29	No	No	0	7	3
533	R:R:T282	R:R:Y266	1.25	No	Yes	0	8	3
534	R:R:V84	R:R:W161	1.23	No	No	0	6	9
535	R:R:L136	S:S:R218	1.21	No	No	0	5	4
536	R:R:L77	R:R:Y154	1.17	No	No	0	4	1
537	S:S:N140	S:S:Y145	1.16	No	No	0	5	4
538	R:R:H223	R:R:R222	1.13	No	No	0	7	5
539	R:R:Q305	R:R:W309	1.1	No	No	0	8	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	S:S:V54	3.208	5	1	7
2	S:S:E57	4.5725	4	1	8
3	S:S:N58	5.452	5	1	9
4	S:S:V61	2.3425	4	1	9
5	S:S:I65	1.8375	4	0	7
6	S:S:F71	5.8875	4	0	8
7	S:S:M75	3.3075	4	4	8
8	S:S:F76	8.1325	4	4	9
9	S:S:V79	1.575	4	0	7
10	S:S:A83	1.7275	4	1	9
11	S:S:D86	5.992	5	1	9
12	S:S:A89	2.0125	4	0	8
13	S:S:G90	1.84	4	0	7
14	S:S:G92	1.71	4	3	4
15	S:S:L95	3.5675	4	3	7
16	S:S:F97	6.2625	4	11	5
17	S:S:L112	3.5175	4	3	5
18	S:S:I124	2.194	5	1	8
19	S:S:L127	3.2125	4	1	8
20	S:S:Y135	6.594	5	10	8
21	S:S:W161	4.094	5	12	9
22	S:S:P171	5.2675	4	2	5
23	S:S:W175	5.28	4	2	4
24	S:S:V186	2.0025	4	0	4
25	S:S:P189	3.56	4	9	3
26	S:S:L190	3.2075	4	2	3
27	S:S:H194	5.77833	6	2	7
28	S:S:F202	5.8875	4	1	8
29	S:S:F203	5.804	5	1	4
30	S:S:F206	3.3875	4	0	6
31	S:S:Q211	7.4925	4	0	2
32	S:S:Y213	5.18	5	0	9
33	S:S:Q215	6.26	4	10	6
34	S:S:L249	4.2975	4	0	7
35	S:S:F256	3.6275	4	1	9
36	S:S:W260	4.36	7	1	8
37	S:S:L261	2.025	4	1	4
38	S:S:Y266	5.89	5	0	3
39	S:S:N293	6.74	4	1	9
40	S:S:P294	6.4275	4	1	9
41	S:S:Y297	3.665	4	1	9
42	R:R:D44	6.43	4	0	4
43	R:R:V54	3.208	5	5	7
44	R:R:N58	6.014	5	5	9
45	R:R:V61	2.36	4	5	9
46	R:R:F71	7.025	4	8	8
47	R:R:F76	4.962	5	8	9
48	R:R:L78	3.458	5	0	8
49	R:R:D86	6.852	5	5	9
50	R:R:A89	2.0125	4	0	8
51	R:R:L95	3.57	4	15	7
52	R:R:L112	3.4375	4	0	5
53	R:R:Y135	4.94	5	10	8
54	R:R:Y144	9.4125	4	0	8
55	R:R:P189	3.4375	4	6	3
56	R:R:V196	3.7625	4	1	3
57	R:R:F202	5.252	5	7	8
58	R:R:F203	5.814	5	7	4
59	R:R:F206	4.275	4	0	6
60	R:R:M209	3.6075	4	0	8
61	R:R:Q211	7.135	4	0	2
62	R:R:Y213	3.946	5	0	9
63	R:R:Q215	7.1825	4	10	6
64	R:R:W260	4.965	4	0	8
65	R:R:L261	2.732	5	7	4
66	R:R:T264	5.025	4	7	5
67	R:R:Y266	3.585	6	16	3
68	R:R:L284	2.6475	4	0	4
69	R:R:P294	5.166	5	5	9
70	R:R:I296	2.7075	4	0	8
71	R:R:Y297	3.6325	4	0	9
72	R:R:D303	6.19	5	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:T279	S:S:Y266	58.7446	4.99	No	Yes	0	4	3
2	S:S:T282	S:S:Y266	63.459	4.99	No	Yes	0	8	3
3	S:S:P262	S:S:T282	64.1218	3.5	No	No	0	9	8
4	S:S:L261	S:S:P262	64.7819	1.64	Yes	No	0	4	9
5	S:S:F202	S:S:L261	21.8435	2.44	Yes	Yes	1	8	4
6	S:S:F202	S:S:W260	25.0368	3.01	Yes	Yes	1	8	8
7	S:S:F120	S:S:W260	28.2704	7.02	No	Yes	0	4	8
8	S:S:F120	S:S:L116	11.8121	2.44	No	No	0	4	5
9	S:S:G92	S:S:L116	11.1386	1.71	Yes	No	0	4	5
10	S:S:A89	S:S:D86	11.4479	1.54	Yes	Yes	0	8	9
11	S:S:A89	S:S:F120	19.8042	2.77	Yes	No	0	8	4
12	S:S:F71	S:S:F76	26.3557	17.15	Yes	Yes	0	8	9
13	S:S:F76	S:S:I65	16.8813	2.51	Yes	Yes	0	9	7
14	S:S:I65	S:S:V79	13.3546	1.54	Yes	Yes	0	7	7
15	S:S:F256	S:S:W260	34.6303	4.01	Yes	Yes	1	9	8
16	S:S:F256	S:S:L127	66.9242	2.44	Yes	Yes	1	9	8
17	S:S:L127	S:S:Y297	50.3843	3.52	Yes	Yes	1	8	9
18	S:S:I130	S:S:Y297	40.5899	4.84	No	Yes	0	9	9
19	S:S:I130	S:S:V79	37.7219	1.54	No	Yes	0	9	7
20	S:S:D303	S:S:F71	11.63	2.39	No	Yes	0	7	8
21	S:S:A73	S:S:P74	10.4598	1.87	No	No	4	7	5
22	S:S:F76	S:S:M75	12.1254	8.71	Yes	Yes	4	9	8
23	S:S:M75	S:S:V79	23.5211	1.52	Yes	Yes	0	8	7
24	S:S:C177	S:S:P189	11.3488	3.77	No	Yes	9	5	3
25	S:S:C177	S:S:T182	17.8199	3.38	No	No	0	5	4
26	S:S:S191	S:S:T182	19.424	4.8	No	No	0	6	4
27	S:S:S191	S:S:W175	21.008	8.65	No	Yes	2	6	4
28	S:S:H194	S:S:W175	28.9358	4.23	Yes	Yes	2	7	4
29	S:S:H194	S:S:L190	36.6454	2.57	Yes	Yes	2	7	3
30	S:S:L190	S:S:V187	25.4519	4.47	Yes	No	0	3	5
31	S:S:V186	S:S:V187	26.203	1.6	Yes	No	0	4	5
32	S:S:T279	S:S:V186	55.2968	1.59	No	Yes	0	4	4
33	S:S:L190	S:S:L195	25.4947	4.15	Yes	No	0	3	5
34	S:S:L195	S:S:V186	26.997	2.98	No	Yes	0	5	4
35	S:S:L190	S:S:P171	12.7454	1.64	Yes	Yes	2	3	5
36	S:S:Y213	S:S:Y297	13.4684	3.97	Yes	Yes	0	9	9
37	S:S:F206	S:S:F256	74.6164	4.29	Yes	Yes	0	6	9
38	S:S:F206	S:S:G207	99.9732	1.51	Yes	No	0	6	4
39	R:R:I208	S:S:G207	100	1.76	No	No	0	5	4
40	R:R:I208	S:S:Q211	26.2097	4.12	No	Yes	0	5	2
41	S:S:Q211	S:S:Q215	12.8726	8.96	Yes	Yes	0	2	6
42	R:R:F202	R:R:I124	57.723	2.51	Yes	No	0	8	8
43	R:R:I124	R:R:V205	52.0298	4.61	No	No	0	8	8
44	R:R:M209	R:R:V205	52.3646	1.52	Yes	No	0	8	8
45	R:R:L128	R:R:M209	95.386	7.07	No	Yes	0	7	8
46	R:R:I208	R:R:L128	95.4771	2.85	No	No	0	5	7
47	R:R:L127	R:R:M209	40.6542	2.83	No	Yes	0	8	8
48	S:S:A257	S:S:F206	43.4205	2.77	No	Yes	0	5	6
49	S:S:A257	S:S:L261	43.0281	1.58	No	Yes	0	5	4
50	R:R:I103	R:R:S105	14.6761	3.1	No	No	0	5	7
51	R:R:A99	R:R:S105	17.8199	1.71	No	No	0	4	7
52	R:R:A99	R:R:L112	18.5992	1.58	No	Yes	0	4	5
53	R:R:L112	R:R:L95	14.6815	5.54	Yes	Yes	0	5	7
54	R:R:G92	R:R:L95	15.7325	1.71	No	Yes	15	4	7
55	R:R:G92	R:R:L116	17.0621	1.71	No	No	0	4	5
56	R:R:F120	R:R:L116	19.2044	2.44	No	No	0	4	5
57	R:R:F120	R:R:W260	40.3931	7.02	No	Yes	0	4	8
58	R:R:F202	R:R:W260	41.2018	2	Yes	Yes	0	8	8
59	R:R:C102	R:R:F101	10.6861	6.98	No	No	0	5	4
60	R:R:C102	R:R:I103	11.4894	1.64	No	No	0	5	5
61	R:R:A89	R:R:D86	11.1668	1.54	Yes	Yes	0	8	9
62	R:R:A89	R:R:F120	22.1809	2.77	Yes	No	0	8	4
63	R:R:L261	R:R:P262	21.4016	1.64	Yes	No	0	4	9
64	R:R:F202	R:R:L261	22.0804	3.65	Yes	Yes	7	8	4
65	R:R:A298	R:R:V61	12.4628	1.7	No	Yes	0	7	9
66	R:R:A298	R:R:V79	12.744	1.7	No	No	0	7	7
67	R:R:I130	R:R:V79	21.5034	1.54	No	No	0	9	7
68	R:R:I130	R:R:Y297	44.4862	2.42	No	Yes	0	9	9
69	R:R:L127	R:R:Y297	43.4285	3.52	No	Yes	0	8	9
70	R:R:F76	R:R:M75	18.2993	3.73	Yes	No	0	9	8
71	R:R:M75	R:R:V79	17.5455	1.52	No	No	0	8	7
72	R:R:I130	R:R:L78	24.3379	5.71	No	Yes	0	9	8
73	R:R:L157	R:R:L78	18.5296	2.77	No	Yes	0	7	8
74	R:R:A122	R:R:W161	15.5692	6.48	No	No	0	7	9
75	R:R:L157	R:R:W161	16.6805	2.28	No	No	0	7	9
76	R:R:A119	R:R:A89	14.8435	1.79	No	Yes	0	6	8
77	R:R:A119	R:R:L88	14.1365	3.15	No	No	0	6	7
78	R:R:L110	R:R:L173	11.4198	2.77	No	No	0	5	4
79	R:R:L173	R:R:V172	13.6719	1.49	No	No	0	4	5
80	R:R:G114	R:R:V172	14.7939	5.52	No	No	0	5	5
81	R:R:G114	R:R:L169	17.03	1.71	No	No	0	5	3
82	R:R:L169	R:R:M118	12.1147	4.24	No	No	0	3	4
83	R:R:A164	R:R:M118	13.842	1.61	No	No	0	8	4
84	R:R:A122	R:R:A164	14.5596	1.79	No	No	0	7	8
85	R:R:L169	R:R:V115	13.3358	1.49	No	No	0	3	4
86	R:R:L88	R:R:V115	13.4925	1.49	No	No	0	7	4
87	R:R:L110	R:R:P189	10.2897	1.64	No	Yes	0	5	3
88	R:R:F263	R:R:T282	10.0273	5.19	No	No	0	6	8
89	R:R:P262	R:R:T282	18.2056	5.25	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9LYD

PDB Summary
PDB	9LYD
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR3
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.66
Date	2025-04-09
D.O.I.	doi.org/10.1016/j.celrep.2025.115478

Net Summary
I_min	1.51
Number of Linked Nodes	473
Number of Links	539
Number of Hubs	72
Number of Links mediated by Hubs	248
Number of Communities	17
Number of Nodes involved in Communities	95
Number of Links involved in Communities	120

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	158420
Length Of Smallest Path	3
Average Path Length	17.9499
Length of Longest Path	42
Minimum Path Strength	1.35
Average Path Strength	3.66013
Maximum Path Strength	15.85
Minimum Path Correlation	0.7
Average Path Correlation	0.959236
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	50.3706
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.7861
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • multicellular organismal process • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of cellular component organization • sexual reproduction • regulation of reproductive process • reproductive process • meiotic cell cycle process • cellular component organization • meiotic nuclear division • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • cell cycle process • regulation of meiotic cell cycle • regulation of cell cycle process • meiotic cell cycle • organelle fission • regulation of organelle organization • regulation of meiotic nuclear division • organelle organization • nuclear division • regulation of nuclear division • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Aspartate/glutamate racemase
SCOP2	Family Identifier	• Aspartate/glutamate racemase
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	S
Protein	Receptor
UniProt	P46089
Sequence	>9LYD_Chain_S A P L P S P K A W D V V L C I S G T L V S C E N A L V V A I I V G T P A F R A P M F L L V G S L A V A D L L A G L G L V L H F A A V F C I G S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N A L T Y Y S E T T V T R T Y V M L A L V W G G A L G L G L L P V L A W N C L D G L T T C G V V Y P L S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A A T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G D A H S P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D V Q K V L W A V C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P46089
Sequence	>9LYD_Chain_R A P L P S P K A W D V V L C I S G T L V S C E N A L V V A I I V G T P A F R A P M F L L V G S L A V A D L L A G L G L V L H F A A V F C I G S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N A L T Y Y S E T T V T R T Y V M L A L V W G G A L G L G L L P V L A W N C L D G L T T C G V V Y P L S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A A T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G D A H S P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D V Q K V L W A V C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8H8J	A	Orphan	Orphan	GPR35	Homo sapiens	Lodoxamide	Ca	chim(NtGi1L-G13)/β1/γ2	3.2	2023-02-08	doi.org/10.1038/s41421-022-00499-8
	8H8J (No Gprot)	A	Orphan	Orphan	GPR35	Homo sapiens	Lodoxamide	Ca		3.2	2023-02-08	doi.org/10.1038/s41421-022-00499-8
	8U8F	A	Orphan	Orphan	GPR3	Homo sapiens	Palmitic Acid	-	Gs/β1/γ2	3.49	2024-03-06	doi.org/10.1021/acs.biochem.3c00647
	8U8F (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	Palmitic Acid	-		3.49	2024-03-06	doi.org/10.1021/acs.biochem.3c00647
	8WW2	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.79	2024-02-14	doi.org/10.1038/s41422-024-00932-5
	8WW2 (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	-	-		2.79	2024-02-14	doi.org/10.1038/s41422-024-00932-5
	9LYB	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYB (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	-	-		3.16	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYC	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	Gs/β1/γ2	3.06	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYC (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	-	-		3.06	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYD	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	-	3.66	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	8X2K	A	Orphan	Orphan	GPR3	Homo sapiens	Oleic monoethanolamide	-	chim(NtGi1-Gs)/β1/γ2	3.03	2024-04-03	doi.org/10.1038/s41422-023-00919-8
	8X2K (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	Oleic monoethanolamide	-		3.03	2024-04-03	doi.org/10.1038/s41422-023-00919-8
	8XOF	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOF (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-		2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOG	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOG (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		2.9	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOH	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOH (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOI	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOI (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOJ	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOJ (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.1	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ1	3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.43	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-	Gi1/β1/γ2	3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-		3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	doi.org/10.1073/pnas.2308435120
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ2	2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.06	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-		2.83	2023-10-25	To be published
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.94	2024-04-10	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9LYD.zip

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