Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 3.875409
2A:A:V34 5.64495
3A:A:L38 7.205408
4A:A:I184 3.682519
5A:A:F196 6.505697
6A:A:K197 9.5425416
7A:A:M198 6.2075407
8A:A:F199 6.88667615
9A:A:Q204 4.76419
10A:A:K210 7.404519
11A:A:W211 4.645619
12A:A:H213 6.3525418
13A:A:F215 5.64619
14A:A:I221 5.545408
15A:A:Y230 5.0456138
16A:A:M247 4.15406
17A:A:F250 5.685109
18A:A:I264 4.9275406
19A:A:L266 4.21254109
20A:A:F267 5.2875409
21A:A:F274 5.6785139
22A:A:Y287 5.078507
23A:A:Y296 4.884504
24A:A:E298 4.58404
25A:A:F307 6.1454108
26A:A:T316 1.655403
27A:A:E318 5.89504
28A:A:F336 5.83833698
29A:A:V339 4.87498
30A:A:I343 4.725407
31A:A:D350 6.99464
32A:A:L353 8.3425407
33B:B:I18 4.485407
34B:B:D27 7.254178
35B:B:I37 3.6775402
36B:B:H54 9.92254119
37B:B:Y59 5.87833618
38B:B:W63 7.416507
39B:B:R68 11.7125425
40B:B:L69 3.6575425
41B:B:L79 3.81527
42B:B:I80 6.5354118
43B:B:I81 3.628527
44B:B:D83 8.215428
45B:B:N88 5.4075427
46B:B:K89 8.2085119
47B:B:I93 5.65407
48B:B:L95 5.2075428
49B:B:W99 8.358519
50B:B:Y105 4.17286726
51B:B:Y111 4.95404
52B:B:C114 4.2425428
53B:B:L117 4.635619
54B:B:N119 4.9725419
55B:B:Y124 6.214526
56B:B:H142 8.745479
57B:B:Y145 5.69375818
58B:B:C149 4.2175478
59B:B:F151 3.68409
60B:B:L152 5.1025403
61B:B:I157 3.558577
62B:B:T159 5.08667679
63B:B:S161 5.88409
64B:B:L168 3.5975406
65B:B:W169 8.81429778
66B:B:I171 3.52406
67B:B:F180 7.82487
68B:B:H183 8.45667689
69B:B:V200 5.23436
70B:B:C204 4.355417
71B:B:D205 6.484589
72B:B:K209 10.975486
73B:B:W211 9.32833688
74B:B:F222 7.215438
75B:B:H225 8.725639
76B:B:D228 7.57419
77B:B:I232 4.388538
78B:B:F235 6.656546
79B:B:P236 6.03447
80B:B:F241 5.41143736
81B:B:T243 6.2225438
82B:B:D247 9.505409
83B:B:T249 6.1625436
84B:B:R251 8.55638
85B:B:F253 6.94667636
86B:B:D258 11.1525437
87B:B:M262 5.0275404
88B:B:T263 4.005431
89B:B:Y264 5.604545
90B:B:S277 2.7725405
91B:B:F278 5.82333647
92B:B:Y289 6.37333647
93B:B:N293 3.9625405
94B:B:V296 4.1145185
95B:B:W297 6.424548
96B:B:K301 4.765405
97B:B:R304 9.745445
98B:B:H311 8.24409
99B:B:C317 3.425407
100B:B:T329 5.785408
101B:B:W332 9.37167619
102B:B:K337 5.76254196
103B:B:W339 7.681676199
104B:B:N340 5.6775429
105G:G:R27 6.59408
106G:G:Y40 10.8675446
107G:G:D48 6.256219
108G:G:L51 3.984506
109G:G:P60 6.68429
110G:G:F61 5.306528
111R:R:Y12 4.11833659
112R:R:F16 5.174126
113R:R:F20 5.26254125
114R:R:N23 4.6725129
115R:R:R37 3.5275464
116R:R:T39 5.8625467
117R:R:L42 4.3575407
118R:R:Y44 5.774507
119R:R:T56 4.186126
120R:R:L61 10.41456
121R:R:K62 8.066557
122R:R:E65 9.8475457
123R:R:W72 6.08559
124R:R:L74 5.068557
125R:R:P80 3.9775457
126R:R:F82 9.815455
127R:R:F88 6.484505
128R:R:Y105 4.6425237
129R:R:F142 5.3975454
130R:R:P147 8.42754243
131R:R:D152 5.4154244
132R:R:T162 2.965402
133R:R:W174 6.23404
134R:R:F191 8.682509
135R:R:Y202 5.2408
136R:R:L214 4.235403
137R:R:N244 8.3845257
138R:R:Y250 2.9825402
139R:R:L253 4.9025403
140R:R:K259 7.275453
141R:R:I263 7.005456
142R:R:V269 5.60254127
143R:R:Y278 3.1775407
144W:W:?1 5.545860
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I81 B:B:L69 24.75622.85YesYes275
2R:R:Y114 W:W:?1 77.37025.34NoYes660
3A:A:N347 R:R:Y114 77.54839.3NoNo686
4A:A:I343 A:A:N347 77.98982.83YesNo078
5A:A:I343 A:A:V339 79.22643.07YesYes078
6A:A:F196 A:A:V339 85.18315.24YesYes978
7A:A:F196 A:A:L36 47.15593.65YesNo077
8A:A:I222 A:A:L36 47.23642.85NoNo077
9A:A:I222 A:A:L38 47.31728.56NoYes078
10A:A:C47 A:A:L38 95.22786.35NoYes098
11A:A:C224 A:A:C47 95.27235.46NoNo079
12A:A:C224 A:A:F267 95.19285.59NoYes079
13A:A:F267 A:A:H322 95.63749.05YesNo099
14A:A:H322 A:A:K330 95.72257.86NoNo094
15A:A:C325 A:A:K330 95.76483.23NoNo074
16A:A:C325 A:A:K271 95.93223.23NoNo075
17A:A:K271 A:A:Y296 95.97365.97NoYes054
18A:A:F323 A:A:Y296 92.75213.09NoYes044
19A:A:F323 A:A:L268 92.82118.53NoNo048
20A:A:L268 A:A:V225 93.50294.47NoNo087
21A:A:F307 A:A:V225 93.5399.18YesNo087
22A:A:F250 A:A:F307 94.40094.29YesYes1098
23A:A:F250 A:A:I264 96.49355.02YesYes096
24A:A:I221 A:A:I264 96.68085.89YesYes086
25A:A:I221 A:A:L37 96.89515.71YesNo089
26A:A:F215 A:A:L37 1006.09YesNo099
27A:A:F215 B:B:W99 24.027812.03YesYes199
28B:B:Q75 B:B:W99 24.40294.38NoYes099
29B:B:Q75 B:B:Y59 24.369310.15NoYes098
30B:B:W332 B:B:Y59 55.72373.86YesYes198
31B:B:S316 B:B:W332 51.59054.94NoYes099
32B:B:C317 B:B:S316 51.32143.44YesNo079
33B:B:C317 B:B:M61 37.29994.86YesNo076
34B:B:M61 B:B:W63 37.02483.49NoYes067
35B:B:S84 B:B:W63 32.53066.18NoYes057
36B:B:S84 G:G:F61 31.44145.28NoYes058
37B:B:Y85 G:G:F61 26.36875.16NoYes248
38B:B:R68 B:B:Y85 27.051620.58YesNo254
39B:B:L69 B:B:R68 25.00053.64YesYes255
40A:A:F189 A:A:F196 47.294510.72NoYes097
41A:A:F189 A:A:M198 47.37537.46NoYes097
42A:A:L38 A:A:M198 47.77778.48YesYes087
43A:A:F215 B:B:L117 48.51153.65YesYes199
44A:A:C214 B:B:L117 48.50263.17NoYes179
45A:A:C214 B:B:Y59 24.18535.38NoYes178
46A:A:C214 A:A:H213 24.25422.95NoYes178
47A:A:H213 B:B:W332 23.98275.29YesYes189
48A:A:W211 B:B:Y145 25.76292.89YesYes198
49A:A:T219 A:A:V342 12.52674.76NoNo077
50A:A:E318 A:A:S263 11.05382.87YesNo047
51A:A:S263 A:A:V342 11.54433.23NoNo077
52R:R:Y44 W:W:?1 69.15839.79YesYes070
53B:B:G162 B:B:Y145 32.32995.79NoYes098
54B:B:G162 B:B:S161 32.24293.71NoYes099
55B:B:H142 B:B:S161 31.629216.74YesYes099
56B:B:H142 B:B:T159 14.81666.85YesYes799
57B:B:I157 B:B:T159 14.39983.04YesYes779
58B:B:I157 B:B:I171 27.15192.94YesYes076
59B:B:I171 B:B:N155 26.6327.08YesNo063
60B:B:D170 B:B:N155 26.19638.08NoNo093
61B:B:D170 B:B:Q156 25.54133.92NoNo095
62B:B:L168 B:B:Q156 25.10393.99YesNo065
63B:B:L168 B:B:V158 23.5414.47YesNo065
64B:B:L190 B:B:V158 22.6692.98NoNo055
65B:B:L190 B:B:S160 22.44833NoNo056
66B:B:S160 B:B:V187 22.00644.85NoNo069
67B:B:H183 B:B:V187 19.72794.15YesNo099
68B:B:H183 B:B:K209 16.541614.41YesYes896
69B:B:K209 B:B:T221 15.694210.51YesNo067
70B:B:T221 G:G:E22 15.50745.64NoNo079
71B:B:I18 G:G:E22 15.35866.83YesNo079
72B:B:H142 B:B:W169 16.58.46YesYes798
73B:B:I157 B:B:W169 14.44273.52YesYes778
74B:B:I18 B:B:R22 13.53635.01YesNo076
75B:B:D258 B:B:R22 13.307710.72YesNo076
76B:B:F278 B:B:L285 15.775610.96YesNo476
77B:B:N237 G:G:Y40 11.348922.1NoYes056
78B:B:N237 B:B:N239 10.75314.09NoNo052
79B:B:N239 B:B:R256 10.157113.26NoNo029
80B:B:C317 B:B:S275 14.14413.44YesNo078
81B:B:L318 B:B:S275 13.5647.51NoNo068
82B:B:I81 B:B:V71 12.14764.61YesNo278
83B:B:L79 B:B:V71 11.87854.47YesNo278
84B:B:D258 B:B:F222 11.69044.78YesYes378
85B:B:R314 B:B:W332 28.868517.99NoYes089
86B:B:D290 B:B:R314 28.585311.91NoNo068
87B:B:C271 B:B:D290 28.02074.67NoNo056
88B:B:C271 B:B:Y289 26.28174.03NoYes457
89B:B:W297 B:B:Y289 23.19175.79YesYes487
90R:R:C127 R:R:Y44 64.81692.69NoYes077
91R:R:C127 R:R:N47 64.59774.72NoNo079
92R:R:N47 R:R:W131 63.89425.65NoNo2299
93R:R:F88 R:R:W131 63.71912.03YesNo059
94R:R:F88 R:R:P89 47.90455.78YesNo058
95R:R:L55 R:R:P89 47.44048.21NoNo078
96R:R:H86 R:R:L55 37.53862.57NoNo067
97R:R:H86 R:R:K62 29.48947.86NoYes067
98R:R:L55 R:R:V269 10.704510.43NoYes077
99R:R:E65 R:R:K62 12.66913.5YesYes577
100R:R:F82 R:R:L61 14.158317.05YesYes556
101R:R:L61 R:R:W72 15.18415.69YesYes569
102R:R:V169 R:R:W72 10.14158.58NoYes059
103R:R:C79 R:R:W72 22.80549.14NoYes599
104R:R:C170 R:R:C79 15.20467.28NoNo599
105R:R:F88 R:R:V134 16.07645.24YesNo057
106R:R:L190 R:R:V134 15.82232.98NoNo067
107R:R:L190 R:R:Y91 15.567919.93NoNo068
108R:R:Y240 R:R:Y91 15.31344.96NoNo088
109R:R:N244 R:R:Y240 14.549620.93YesNo078
110R:R:C170 R:R:G159 13.94311.96NoNo094
111R:R:G159 R:R:I160 12.67641.76NoNo042
112R:R:I160 R:R:T162 10.14253.04NoYes022
113A:A:F215 A:A:W211 26.53174.01YesYes199
114B:B:L285 B:B:W297 15.30974.56NoYes468
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:N347 R:R:G107 3.39 6 No No 8 8 2 2
A:A:N347 R:R:Y114 9.3 6 No No 8 6 2 1
A:A:D350 R:R:T39 7.23 6 Yes Yes 4 7 2 2
A:A:D350 R:R:P40 6.44 6 Yes No 4 7 2 1
R:R:P40 R:R:T39 3.5 6 No Yes 7 7 1 2
R:R:P40 W:W:?1 4.99 6 No Yes 7 0 1 0
R:R:A99 R:R:Y44 5.34 0 No Yes 6 7 2 1
R:R:L100 R:R:Y44 4.69 0 No Yes 8 7 2 1
R:R:S123 R:R:Y44 6.36 0 No Yes 8 7 2 1
R:R:Y44 W:W:?1 9.79 0 Yes Yes 7 0 1 0
R:R:A102 W:W:?1 3.59 0 No Yes 6 0 1 0
R:R:G103 R:R:L106 3.42 6 No No 8 7 1 1
R:R:G103 W:W:?1 3.9 6 No Yes 8 0 1 0
R:R:L106 W:W:?1 5.26 6 No Yes 7 0 1 0
R:R:G107 R:R:Y114 8.69 6 No No 8 6 2 1
R:R:Y114 W:W:?1 5.34 6 No Yes 6 0 1 0
R:R:I130 W:W:?1 6.5 0 No Yes 6 0 1 0
R:R:L193 R:R:P194 3.28 0 No No 4 9 2 1
R:R:P194 W:W:?1 4.99 0 No Yes 9 0 1 0
R:R:C127 R:R:Y44 2.69 0 No Yes 7 7 2 1
R:R:A102 R:R:C201 1.81 0 No No 6 7 1 2
R:R:I130 R:R:V126 1.54 0 No No 6 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
44.44Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
33.33Single9CM3Compound 1879CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
31.25Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/β1/γ2
30.77Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
30.00Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
28.57Single7WU3K6G7WU3-ADGRF1-K6G-Gs/β1/γ2
27.27Single9NS9Compound 1879NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
26.32Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
25.00Single8XXUA1D5Q8XXU-DP2-A1D5Q-Gi1/β1/γ2
25.00Single9IYBA1D5Q9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
21.43Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
21.43Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
21.43Single9JCQLPC9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
20.00Single6N48PubChem 1384542566N48-β2-BI167107-PubChem 138454256
17.65Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/β1/γ2
17.65Single8YYXLeukotriene e48YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
16.67Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.38Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
14.29Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
14.29Single8K9LBMS-9861228K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
14.29Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
6.67Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
6.67Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.67Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
6.25Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
6.25Single7LJCMevidalen7LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
6.25Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.88Single5O9HNDT95137275O9H-C5a1-NDT9513727

PDB Summary
PDB 9K1C
Class A
SubFamily Lipid
Type Free Fatty Acid
SubType FFA1
Species Homo Sapiens
Ligand -
Other Ligand(s) DHA
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-12-11
D.O.I. doi.org/10.1016/j.celrep.2024.115024
Net Summary
Imin 2.85
Number of Linked Nodes 814
Number of Links 963
Number of Hubs 144
Number of Links mediated by Hubs 533
Number of Communities 25
Number of Nodes involved in Communities 192
Number of Links involved in Communities 272
Path Summary
Number Of Nodes in MetaPath 115
Number Of Links MetaPath 114
Number of Shortest Paths 1557066
Length Of Smallest Path 3
Average Path Length 41.9955
Length of Longest Path 78
Minimum Path Strength 1.26
Average Path Strength 6.0574
Maximum Path Strength 24.525
Minimum Path Correlation 0.71
Average Path Correlation 0.986261
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 37.7039
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.0558
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • lipid binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • bioactive lipid receptor activity   • positive regulation of cytosolic calcium ion concentration   • regulation of calcium ion transport   • positive regulation of calcium ion transport   • regulation of monoatomic ion transport   • calcium ion transport   • metal ion transport   • positive regulation of transport   • positive regulation of monoatomic ion transport   • monoatomic ion transport   • monoatomic cation transport   • regulation of metal ion transport   • response to fatty acid   • interleukin-1 production   • regulation of interleukin-1 beta production   • negative regulation of interleukin-1 beta production   • negative regulation of interleukin-1 production   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • negative regulation of macromolecule metabolic process   • regulation of interleukin-1 production   • negative regulation of metabolic process   • negative regulation of cytokine production   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • negative regulation of gene expression   • negative regulation of biosynthetic process   • interleukin-1 beta production   • negative regulation of macromolecule biosynthetic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • negative regulation of multicellular organismal process   • positive regulation of cell communication   • positive regulation of establishment of protein localization   • positive regulation of insulin secretion   • positive regulation of peptide hormone secretion   • positive regulation of secretion by cell   • positive regulation of protein transport   • positive regulation of hormone secretion   • positive regulation of secretion   • positive regulation of peptide secretion   • positive regulation of protein secretion   • positive regulation of signaling   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • ligand-gated ion channel signaling pathway
SCOP2Domain Identifier• Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeHXA
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeHXA
NameDoconexent
Synonyms4,7,10,13,16,19-docosahexaenoic acid
Identifier
FormulaC22 H32 O2
Molecular Weight328.488
SMILES
PubChem445580
Formal Charge0
Total Atoms56
Total Chiral Atoms0
Total Bonds55
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>9K1C_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKTI 
VKQMKITGI VETHFTFKD LHFKMFDVQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVLNRMHSM KLFDSICNN KWFTDTSII LFLNKKDLF 
EEKIKKSPL TICYPEYAG SNTYEEAAA YIQCQFEDL NKRKDTKEI 
YTHFTCTDT KNVQFVFDA VTDVIIKNN LKDCGLFCT AAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9K1C_Chain_B
QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR RTLRGHLAK 
IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI PLRSSWVMT 
CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE LAGHTGYLS 
CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH TGDVMSLSL 
APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD INAICFFPN 
GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI TSVSFSKSG 
RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL GVTDDGMAV 
ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9K1C_Chain_G
QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO14842
Sequence
>9K1C_Chain_R
MDLPPQLSF GLYVAAFAL GFPLNVLAI RGATAHARL RLTPSLVYA 
LNLGCSDLL LTVSLPLKA VEALASGAW PLPASLCPV FAVAHFFPL 
YAGGGFLAA LSAGRYLGA AFPLGYQAF RRPCYSWGV CAAIWALVL 
CHLGLVFGL EAPGGWLDH SNTSLGINT PVNGSPVCL EAWDPASAG 
PARFSLSLL LFFLPLAIT AFCYVGCLR ALARSGLTH RRKLRAAWV 
AGGALLTLL LCVGPYNAS NVASFLYPN LGGSWRKLG LITGAWSVV 
LNPLVTGYL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5KW2ALipidFree Fatty AcidFFA1Homo sapiens-PubChem 133053953-2.762018-05-02doi.org/10.1038/s41467-017-01240-w
5TZYALipidFree Fatty AcidFFA1Homo sapiens-MK8666; AP8-3.222017-06-07doi.org/10.1038/nsmb.3417
5TZRALipidFree Fatty AcidFFA1Homo sapiens-MK8666-2.22017-06-07doi.org/10.1038/nsmb.3417
4PHUALipidFree Fatty AcidFFA1Homo sapiens-Fasiglifam-2.332014-07-16doi.org/10.1038/nature13494
9K1CALipidFree Fatty AcidFFA1Homo sapiens-DHAGi1/β1/γ23.22024-12-11doi.org/10.1016/j.celrep.2024.115024
9K1C (No Gprot) ALipidFree Fatty AcidFFA1Homo sapiens-DHA3.22024-12-11doi.org/10.1016/j.celrep.2024.115024
8EITALipidFree Fatty AcidFFA1Homo sapiensDoconexent-chim(NtGi1L-Gs-CtGq)/β1/γ22.82023-05-24doi.org/10.1073/pnas.2219569120
8EIT (No Gprot) ALipidFree Fatty AcidFFA1Homo sapiensDoconexent-2.82023-05-24doi.org/10.1073/pnas.2219569120
8EJCALipidFree Fatty AcidFFA1Homo sapiensTAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ232023-05-24doi.org/10.1073/pnas.2219569120
8EJC (No Gprot) ALipidFree Fatty AcidFFA1Homo sapiensTAK-875-32023-05-24doi.org/10.1073/pnas.2219569120
8EJKALipidFree Fatty AcidFFA1Homo sapiensTAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ23.42023-05-24doi.org/10.1073/pnas.2219569120
8EJK (No Gprot) ALipidFree Fatty AcidFFA1Homo sapiensTAK-875-3.42023-05-24doi.org/10.1073/pnas.2219569120
8T3VALipidFree Fatty AcidFFA1Homo sapiensDocosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ23.392024-01-24doi.org/10.1126/sciadv.adj2384
8T3V (No Gprot) ALipidFree Fatty AcidFFA1Homo sapiensDocosa-4,7,10,13,16,19-Hexaenoic acid-3.392024-01-24doi.org/10.1126/sciadv.adj2384




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