psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:P80	5.82	Yes	No	3	0	7
2	L:L:?1	R:R:V84	7.39	Yes	No	0	0	6
3	L:L:?1	R:R:F87	14.67	Yes	No	0	0	6
4	L:L:?1	R:R:L138	16.67	Yes	No	0	0	6
5	L:L:?1	R:R:V141	4.22	Yes	No	0	0	5
6	L:L:?1	R:R:F142	23.29	Yes	No	0	0	4
7	L:L:?1	R:R:L158	6.86	Yes	No	3	0	1
8	L:L:?1	R:R:L171	3.92	Yes	No	0	0	5
9	L:L:?1	R:R:R183	7.74	Yes	No	0	0	6
10	R:R:L3	R:R:S8	4.5	Yes	No	0	7	3
11	R:R:K259	R:R:L3	21.15	No	Yes	0	3	7
12	R:R:L7	R:R:P4	9.85	No	No	0	7	6
13	R:R:P5	R:R:S69	5.34	No	No	0	7	4
14	R:R:F9	R:R:V13	7.87	No	No	0	6	6
15	R:R:F9	R:R:L67	17.05	No	No	0	6	4
16	R:R:L11	R:R:W267	6.83	No	No	0	5	4
17	R:R:K62	R:R:Y12	11.94	No	Yes	0	7	9
18	R:R:L262	R:R:Y12	3.52	Yes	Yes	0	5	9
19	R:R:I263	R:R:Y12	3.63	No	Yes	0	6	9
20	R:R:A266	R:R:Y12	5.34	No	Yes	0	6	9
21	R:R:A15	R:R:W267	3.89	No	No	0	7	4
22	R:R:F16	R:R:T56	3.89	No	No	0	6	6
23	R:R:G19	R:R:L22	5.13	Yes	No	2	8	7
24	R:R:G19	R:R:V270	3.68	Yes	No	2	8	6
25	R:R:F20	R:R:V24	3.93	No	No	0	5	3
26	R:R:F20	R:R:L53	3.65	No	No	0	5	7
27	R:R:F20	R:R:T56	5.19	No	No	0	5	6
28	R:R:L22	R:R:V270	4.47	No	No	2	7	6
29	R:R:L22	R:R:P273	4.93	No	Yes	2	7	9
30	R:R:D52	R:R:N23	14.81	No	No	2	9	9
31	R:R:L53	R:R:N23	13.73	No	No	0	7	9
32	R:R:N23	R:R:P273	4.89	No	Yes	2	9	9
33	R:R:I27	R:R:L53	4.28	Yes	No	0	7	7
34	R:R:H33	R:R:Y278	11.98	No	Yes	0	4	7
35	R:R:A34	R:R:L42	6.3	No	No	0	5	7
36	R:R:L38	R:R:V43	4.47	No	No	0	5	7
37	R:R:L38	R:R:P120	9.85	No	No	0	5	4
38	R:R:P40	R:R:T39	3.5	Yes	No	0	7	7
39	R:R:S41	R:R:T39	4.8	No	No	0	7	7
40	R:R:L42	R:R:T39	7.37	No	No	0	7	7
41	R:R:P40	R:R:Y114	4.17	Yes	No	1	7	6
42	R:R:P40	R:R:R118	5.76	Yes	No	1	7	8
43	R:R:P40	R:R:S123	5.34	Yes	Yes	1	7	8
44	R:R:S41	R:R:Y278	3.82	No	Yes	0	7	7
45	R:R:L42	R:R:Y278	9.38	No	Yes	0	7	7
46	R:R:S123	R:R:V43	9.7	Yes	No	1	8	7
47	R:R:V43	R:R:W124	18.39	No	Yes	1	7	4
48	R:R:A99	R:R:Y44	5.34	No	Yes	0	6	7
49	R:R:L100	R:R:Y44	7.03	No	Yes	0	8	7
50	R:R:S123	R:R:Y44	3.82	Yes	Yes	0	8	7
51	R:R:F96	R:R:N47	12.08	Yes	Yes	1	6	9
52	R:R:N47	R:R:W124	6.78	Yes	Yes	1	9	4
53	R:R:C127	R:R:N47	6.3	No	Yes	0	7	9
54	R:R:N47	R:R:W131	9.04	Yes	Yes	1	9	9
55	R:R:F96	R:R:L48	3.65	Yes	No	0	6	9
56	R:R:L48	R:R:N272	12.36	No	No	0	9	9
57	R:R:F96	R:R:S51	6.61	Yes	No	0	6	8
58	R:R:D52	R:R:V269	10.22	No	No	0	9	7
59	R:R:D52	R:R:P273	9.66	No	Yes	2	9	9
60	R:R:L55	R:R:L59	4.15	Yes	No	0	7	9
61	R:R:L55	R:R:P89	9.85	Yes	No	0	7	8
62	R:R:L55	R:R:V269	7.45	Yes	No	0	7	7
63	R:R:H86	R:R:S58	6.97	No	No	0	6	7
64	R:R:F82	R:R:L61	8.53	No	No	0	5	6
65	R:R:E65	R:R:K62	4.05	No	No	0	7	7
66	R:R:F82	R:R:K62	3.72	No	No	0	5	7
67	R:R:P73	R:R:V64	3.53	No	No	0	4	4
68	R:R:E65	R:R:G70	4.91	No	No	0	7	6
69	R:R:E172	R:R:E65	3.81	No	No	0	6	7
70	R:R:A68	R:R:P73	3.74	No	No	0	3	4
71	R:R:P73	R:R:W72	4.05	No	No	0	4	9
72	R:R:L74	R:R:W72	15.94	No	No	0	7	9
73	R:R:C170	R:R:W72	3.92	No	No	0	9	9
74	R:R:L74	R:R:P75	4.93	No	No	0	7	8
75	R:R:L74	R:R:L78	4.15	No	No	0	7	5
76	R:R:A76	R:R:I160	6.5	No	Yes	0	3	2
77	R:R:C170	R:R:C79	3.64	No	No	0	9	9
78	R:R:L158	R:R:P80	4.93	No	No	3	1	7
79	R:R:C170	R:R:F82	4.19	No	No	0	9	5
80	R:R:F87	R:R:H86	10.18	No	No	0	6	6
81	R:R:H86	R:R:L262	3.86	No	Yes	0	6	5
82	R:R:F87	R:R:Y240	6.19	No	No	0	6	8
83	R:R:F88	R:R:P89	5.78	Yes	No	0	5	8
84	R:R:A92	R:R:F88	5.55	No	Yes	0	6	5
85	R:R:F88	R:R:W131	7.02	Yes	Yes	0	5	9
86	R:R:F88	R:R:V134	3.93	Yes	No	0	5	7
87	R:R:F88	R:R:L135	3.65	Yes	No	0	5	3
88	R:R:L186	R:R:Y91	8.21	No	No	0	6	8
89	R:R:L190	R:R:Y91	9.38	Yes	No	0	6	8
90	R:R:F96	R:R:I130	6.28	Yes	No	0	6	6
91	R:R:F96	R:R:W131	12.03	Yes	Yes	1	6	9
92	R:R:L233	R:R:L97	5.54	Yes	No	0	9	8
93	R:R:L100	R:R:R104	13.36	No	No	0	8	9
94	R:R:S101	R:R:T198	7.99	No	No	0	9	8
95	R:R:L106	R:R:Y105	3.52	No	Yes	0	7	7
96	R:R:A109	R:R:Y105	5.34	No	Yes	0	8	7
97	R:R:C201	R:R:Y105	6.72	Yes	Yes	0	7	7
98	R:R:G107	R:R:Y114	8.69	No	No	0	8	6
99	R:R:R118	R:R:Y114	6.17	No	No	1	8	6
100	R:R:A116	R:R:F117	8.32	No	No	0	3	4
101	R:R:R119	R:R:Y122	13.38	No	No	0	5	3
102	R:R:S123	R:R:W124	3.71	Yes	Yes	1	8	4
103	R:R:L190	R:R:V134	4.47	Yes	No	0	6	7
104	R:R:H137	R:R:L186	7.71	No	No	0	5	6
105	R:R:H137	R:R:L190	5.14	No	Yes	0	5	6
106	R:R:L186	R:R:V141	4.47	No	No	0	6	5
107	R:R:E145	R:R:F142	7	No	No	0	4	4
108	R:R:E145	R:R:G159	4.91	No	No	0	4	4
109	R:R:E145	R:R:W174	17.45	No	Yes	0	4	4
110	R:R:P168	R:R:T162	5.25	No	No	0	4	2
111	R:R:G166	R:R:P163	6.09	No	No	0	4	4
112	R:R:E172	R:R:V169	5.7	No	No	0	6	5
113	R:R:L171	R:R:W174	6.83	No	Yes	0	5	4
114	R:R:S178	R:R:W174	6.18	No	Yes	0	1	4
115	R:R:A179	R:R:W174	10.37	No	Yes	0	4	4
116	R:R:D175	R:R:P176	4.83	No	No	0	6	1
117	R:R:D175	R:R:S178	8.83	No	No	0	6	1
118	R:R:G180	R:R:P181	4.06	No	No	0	3	4
119	R:R:F248	R:R:P181	5.78	No	No	0	5	4
120	R:R:N244	R:R:R183	13.26	No	No	0	7	6
121	R:R:R183	R:R:R258	15.99	No	No	0	6	7
122	R:R:F184	R:R:L188	3.65	Yes	No	0	4	4
123	R:R:F184	R:R:V245	3.93	Yes	No	0	4	5
124	R:R:F184	R:R:F248	31.08	Yes	No	0	4	5
125	R:R:N241	R:R:S187	10.43	No	No	0	9	5
126	R:R:N244	R:R:S187	8.94	No	No	0	7	5
127	R:R:F191	R:R:F192	6.43	Yes	No	0	9	4
128	R:R:F191	R:R:L233	3.65	Yes	Yes	0	9	9
129	R:R:F191	R:R:V237	5.24	Yes	No	5	9	8
130	R:R:F191	R:R:G238	4.52	Yes	No	0	9	4
131	R:R:F191	R:R:N241	22.96	Yes	No	5	9	9
132	R:R:L195	R:R:L233	4.15	No	Yes	0	6	9
133	R:R:L230	R:R:T198	4.42	No	No	0	8	8
134	R:R:L233	R:R:T198	4.42	Yes	No	0	9	8
135	R:R:L206	R:R:Y202	10.55	No	Yes	0	5	8
136	R:R:A226	R:R:Y202	4	No	Yes	0	7	8
137	R:R:G227	R:R:Y202	7.24	No	Yes	0	4	8
138	R:R:L230	R:R:Y202	4.69	No	Yes	0	8	8
139	R:R:R207	R:R:R211	5.33	No	No	0	4	4
140	R:R:G213	R:R:K219	5.23	No	No	0	4	6
141	R:R:L214	R:R:R218	3.64	No	No	0	3	5
142	R:R:R218	R:R:T215	7.76	No	No	0	5	3
143	R:R:H216	R:R:L220	11.57	No	No	0	2	4
144	R:R:R221	R:R:W224	6	No	No	0	7	5
145	R:R:G228	R:R:L231	5.13	No	No	0	5	5
146	R:R:G228	R:R:V275	3.68	No	Yes	0	5	7
147	R:R:L271	R:R:T232	7.37	No	No	0	6	6
148	R:R:T232	R:R:V275	4.76	No	Yes	0	6	7
149	R:R:C236	R:R:S268	5.16	No	No	0	8	9
150	R:R:N241	R:R:V237	4.43	No	No	5	9	8
151	R:R:G238	R:R:P239	4.06	No	No	0	4	9
152	R:R:P239	R:R:T264	10.49	No	No	0	9	5
153	R:R:R258	R:R:Y240	7.2	No	No	4	7	8
154	R:R:L262	R:R:Y240	4.69	Yes	No	4	5	8
155	R:R:L249	R:R:Y250	8.21	No	Yes	0	4	2
156	R:R:L253	R:R:W257	9.11	Yes	No	0	3	5
157	R:R:S256	R:R:W257	6.18	No	No	0	1	5
158	R:R:L262	R:R:R258	4.86	Yes	No	4	5	7
159	R:R:G261	R:R:T264	5.46	No	No	0	6	5
160	R:R:C201	R:R:S101	3.44	Yes	No	0	7	9
161	R:R:A66	R:R:S8	3.42	No	No	0	6	3
162	R:R:A71	R:R:S167	3.42	No	No	0	4	3
163	R:R:I160	R:R:P168	3.39	Yes	No	0	2	4
164	R:R:L3	R:R:P4	3.28	Yes	No	0	7	6
165	R:R:L3	R:R:P5	3.28	Yes	No	0	7	7
166	R:R:L54	R:R:P89	3.28	No	No	0	7	8
167	R:R:L193	R:R:P194	3.28	No	No	0	4	9
168	R:R:C79	R:R:I160	3.27	No	Yes	0	9	2
169	R:R:S268	R:R:V237	3.23	No	No	0	9	8
170	R:R:C236	R:R:L235	3.17	No	No	0	8	5
171	R:R:C236	R:R:L271	3.17	No	No	0	8	6
172	R:R:T276	R:R:V275	3.17	No	Yes	0	7	7
173	R:R:A30	R:R:L46	3.15	No	No	0	6	6
174	R:R:A222	R:R:L209	3.15	No	No	0	8	8
175	R:R:I160	R:R:S157	3.1	Yes	No	0	2	2
176	R:R:A177	R:R:D175	3.09	No	No	0	1	6
177	R:R:I160	R:R:T156	3.04	Yes	No	0	2	1
178	R:R:F9	R:R:G10	3.01	No	No	0	6	5
179	R:R:F96	R:R:G93	3.01	Yes	No	0	6	9
180	R:R:L78	R:R:V81	2.98	No	No	0	5	5
181	R:R:G204	R:R:Y105	2.9	No	Yes	0	4	7
182	R:R:F16	R:R:P60	2.89	No	No	0	6	9
183	R:R:K219	R:R:L214	2.82	No	No	0	6	3
184	R:R:H137	R:R:S185	2.79	No	No	0	5	5
185	R:R:L11	R:R:L7	2.77	No	No	0	5	7
186	R:R:L55	R:R:L90	2.77	Yes	No	0	7	7
187	R:R:L189	R:R:L190	2.77	No	Yes	0	5	6
188	R:R:L195	R:R:L234	2.77	No	No	0	6	5
189	R:R:A63	R:R:Y12	2.67	No	Yes	0	7	9
190	R:R:A45	R:R:Y278	2.67	No	Yes	0	7	7
191	R:R:H33	R:R:L279	2.57	No	No	0	4	5
192	R:R:V126	R:R:Y44	2.52	No	Yes	0	5	7
193	R:R:V225	R:R:W224	2.45	No	No	0	7	5
194	R:R:V270	R:R:W267	2.45	No	No	0	6	4
195	R:R:L220	R:R:R217	2.43	No	No	0	4	3
196	L:L:?1	R:R:A83	2.23	Yes	No	0	0	6
197	R:R:G93	R:R:G94	2.11	No	No	0	9	8
198	R:R:G94	R:R:G95	2.11	No	No	0	8	5
199	R:R:G254	R:R:G255	2.11	No	No	0	6	5
200	R:R:G19	R:R:P21	2.03	Yes	No	0	8	5
201	R:R:A26	R:R:G277	1.95	No	No	0	9	4
202	R:R:A32	R:R:G29	1.95	No	No	0	3	7
203	R:R:A98	R:R:G95	1.95	No	No	0	7	5
204	R:R:A102	R:R:G103	1.95	No	No	0	6	8
205	R:R:A116	R:R:G113	1.95	No	No	0	3	4
206	R:R:A26	R:R:P273	1.87	No	Yes	0	9	9
207	R:R:A98	R:R:P194	1.87	No	No	0	7	9
208	R:R:A146	R:R:P147	1.87	No	No	0	3	3
209	R:R:G261	R:R:S243	1.86	No	No	0	6	5
210	R:R:G265	R:R:S268	1.86	No	No	0	8	9
211	R:R:G204	R:R:V203	1.84	No	No	0	4	3
212	R:R:A102	R:R:C201	1.81	No	Yes	0	6	7
213	R:R:A108	R:R:C205	1.81	No	No	0	8	7
214	R:R:A68	R:R:A71	1.79	No	No	0	3	4
215	R:R:A108	R:R:A208	1.79	No	No	0	8	5
216	R:R:G49	R:R:I27	1.76	No	Yes	0	8	7
217	R:R:P163	R:R:T162	1.75	No	No	0	4	2
218	R:R:G19	R:R:L18	1.71	Yes	No	0	8	6
219	R:R:A85	R:R:S58	1.71	No	No	0	5	7
220	R:R:G113	R:R:L112	1.71	No	No	0	4	6
221	R:R:G139	R:R:L138	1.71	No	No	0	4	6
222	R:R:G254	R:R:L253	1.71	No	Yes	0	6	3
223	R:R:G261	R:R:L260	1.71	No	No	0	6	3
224	R:R:A182	R:R:V141	1.7	No	No	0	4	5
225	R:R:A173	R:R:V169	1.7	No	No	0	5	5
226	R:R:A229	R:R:T276	1.68	No	No	0	8	7
227	R:R:C50	R:R:I27	1.64	No	Yes	0	4	7
228	R:R:C201	R:R:I197	1.64	Yes	No	0	7	6
229	R:R:C136	R:R:L140	1.59	No	No	0	4	7
230	R:R:C205	R:R:L209	1.59	No	No	0	7	8
231	R:R:A146	R:R:L158	1.58	No	No	0	3	1
232	R:R:A223	R:R:L206	1.58	No	No	0	5	5
233	R:R:A246	R:R:L253	1.58	No	Yes	0	5	3
234	R:R:G29	R:R:R28	1.5	No	No	0	7	2
235	R:R:L78	R:R:S77	1.5	No	No	0	5	1
236	R:R:G204	R:R:R207	1.5	No	No	0	4	4
237	R:R:L274	R:R:V275	1.49	No	Yes	0	6	7
238	R:R:N165	R:R:V164	1.48	No	No	0	4	2
239	R:R:F110	R:R:P111	1.44	No	No	0	6	9
240	R:R:P120	R:R:R119	1.44	No	No	0	4	5
241	R:R:I27	R:R:L46	1.43	Yes	No	0	7	6
242	R:R:G125	R:R:W124	1.41	No	Yes	0	1	4
243	R:R:K219	R:R:L209	1.41	No	No	0	6	8
244	R:R:A109	R:R:F110	1.39	No	No	0	8	6
245	R:R:P251	R:R:Y250	1.39	No	Yes	0	2	2
246	R:R:L25	R:R:L279	1.38	No	No	0	5	5
247	R:R:L133	R:R:L189	1.38	No	No	0	5	5
248	R:R:F184	R:R:S185	1.32	Yes	No	0	4	5
249	R:R:R104	R:R:V225	1.31	No	No	0	9	7
250	R:R:F200	R:R:V203	1.31	No	No	0	4	3
251	R:R:A128	R:R:W131	1.3	No	Yes	0	4	9
252	R:R:R35	R:R:T31	1.29	No	No	0	5	1
253	R:R:R217	R:R:T215	1.29	No	No	0	3	3
254	R:R:S243	R:R:W257	1.24	No	No	0	5	5
255	R:R:L36	R:R:R35	1.21	No	No	0	4	5
256	R:R:L253	R:R:Y250	1.17	Yes	Yes	0	3	2
257	R:R:N252	R:R:Y250	1.16	No	Yes	0	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.281	10	3	0
2	R:R:L3	8.0525	4	0	7
3	R:R:Y12	5.42	5	0	9
4	R:R:G19	3.1375	4	2	8
5	R:R:I27	2.2775	4	0	7
6	R:R:P40	4.6925	4	1	7
7	R:R:Y44	4.6775	4	0	7
8	R:R:N47	8.55	4	1	9
9	R:R:L55	6.055	4	0	7
10	R:R:F88	5.186	5	0	5
11	R:R:F96	7.27667	6	1	6
12	R:R:Y105	4.62	4	0	7
13	R:R:S123	5.6425	4	1	8
14	R:R:W124	7.5725	4	1	4
15	R:R:W131	7.3475	4	1	9
16	R:R:I160	3.86	5	0	2
17	R:R:W174	10.2075	4	0	4
18	R:R:F184	9.995	4	0	4
19	R:R:L190	5.44	4	0	6
20	R:R:F191	8.56	5	5	9
21	R:R:C201	3.4025	4	0	7
22	R:R:Y202	6.62	4	0	8
23	R:R:L233	4.44	4	0	9
24	R:R:Y250	2.9825	4	0	2
25	R:R:L253	3.3925	4	0	3
26	R:R:L262	4.2325	4	4	5
27	R:R:P273	5.3375	4	2	9
28	R:R:V275	3.275	4	0	7
29	R:R:Y278	6.9625	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V141	99.9166	4.22	Yes	No	0	0	5
2	R:R:L186	R:R:V141	100	4.47	No	No	0	6	5
3	R:R:L186	R:R:Y91	48.2524	8.21	No	No	0	6	8
4	R:R:L190	R:R:Y91	47.9914	9.38	Yes	No	0	6	8
5	R:R:L190	R:R:V134	95.2967	4.47	Yes	No	0	6	7
6	R:R:F88	R:R:V134	94.4787	3.93	Yes	No	0	5	7
7	R:R:F88	R:R:P89	45.5375	5.78	Yes	No	0	5	8
8	R:R:L55	R:R:P89	43.3257	9.85	Yes	No	0	7	8
9	R:R:L55	R:R:V269	39.9677	7.45	Yes	No	0	7	7
10	R:R:D52	R:R:V269	38.8376	10.22	No	No	0	9	7
11	R:R:D52	R:R:P273	23.1185	9.66	No	Yes	2	9	9
12	R:R:L22	R:R:P273	20.0996	4.93	No	Yes	2	7	9
13	R:R:L22	R:R:V270	15.0841	4.47	No	No	2	7	6
14	R:R:V270	R:R:W267	13.9378	2.45	No	No	0	6	4
15	R:R:L11	R:R:W267	11.4355	6.83	No	No	0	5	4
16	R:R:L11	R:R:L7	10.265	2.77	No	No	0	5	7
17	R:R:H137	R:R:L186	51.8472	7.71	No	No	0	5	6
18	R:R:H137	R:R:L190	49.7592	5.14	No	Yes	0	5	6
19	L:L:?1	R:R:F87	42.914	14.67	Yes	No	0	0	6
20	R:R:F87	R:R:Y240	20.3902	6.19	No	No	0	6	8
21	R:R:L262	R:R:Y240	19.9166	4.69	Yes	No	4	5	8
22	L:L:?1	R:R:R183	56.6851	7.74	Yes	No	0	0	6
23	R:R:R183	R:R:R258	26.5815	15.99	No	No	0	6	7
24	R:R:L262	R:R:R258	25.8334	4.86	Yes	No	4	5	7
25	R:R:F87	R:R:H86	21.9938	10.18	No	No	0	6	6
26	R:R:H86	R:R:L262	20.4763	3.86	No	Yes	0	6	5
27	R:R:L262	R:R:Y12	63.4037	3.52	Yes	Yes	0	5	9
28	R:R:D52	R:R:N23	14.5809	14.81	No	No	2	9	9
29	R:R:L53	R:R:N23	13.9513	13.73	No	No	0	7	9
30	R:R:F88	R:R:W131	56.4025	7.02	Yes	Yes	0	5	9
31	R:R:N47	R:R:W131	41.3454	9.04	Yes	Yes	1	9	9
32	R:R:N47	R:R:W124	40.1695	6.78	Yes	Yes	1	9	4
33	R:R:S123	R:R:W124	31.9763	3.71	Yes	Yes	1	8	4
34	R:R:P40	R:R:S123	22.1176	5.34	Yes	Yes	1	7	8
35	R:R:P40	R:R:T39	17.5703	3.5	Yes	No	0	7	7
36	R:R:F96	R:R:W131	12.9611	12.03	Yes	Yes	1	6	9
37	R:R:K62	R:R:Y12	56.1039	11.94	No	Yes	0	7	9
38	R:R:F82	R:R:K62	45.0666	3.72	No	No	0	5	7
39	R:R:C170	R:R:F82	41.4234	4.19	No	No	0	9	5
40	R:R:C170	R:R:W72	22.1364	3.92	No	No	0	9	9
41	R:R:P73	R:R:W72	10.1413	4.05	No	No	0	4	9
42	R:R:L74	R:R:W72	10.1413	15.94	No	No	0	7	9
43	R:R:C170	R:R:C79	18.0035	3.64	No	No	0	9	9
44	R:R:C79	R:R:I160	16.007	3.27	No	Yes	0	9	2
45	R:R:N244	R:R:R183	42.3006	13.26	No	No	0	7	6
46	R:R:N244	R:R:S187	41.7516	8.94	No	No	0	7	5
47	R:R:N241	R:R:S187	41.1974	10.43	No	No	0	9	5
48	R:R:F191	R:R:N241	31.3332	22.96	Yes	No	5	9	9
49	R:R:F191	R:R:L233	20.6189	3.65	Yes	Yes	0	9	9
50	R:R:L233	R:R:T198	17.6591	4.42	Yes	No	0	9	8
51	R:R:S101	R:R:T198	12.4284	7.99	No	No	0	9	8
52	R:R:C201	R:R:S101	11.6373	3.44	Yes	No	0	7	9
53	R:R:F191	R:R:G238	13.214	4.52	Yes	No	0	9	4
54	R:R:S268	R:R:V237	10.039	3.23	No	No	0	9	8
55	R:R:G238	R:R:P239	12.4284	4.06	No	No	0	4	9
56	R:R:P239	R:R:T264	11.6373	10.49	No	No	0	9	5
57	R:R:G261	R:R:T264	10.8408	5.46	No	No	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:P80	5.82	3	Yes	No	0	7	0	1
L:L:?1	R:R:V84	7.39	3	Yes	No	0	6	0	1
L:L:?1	R:R:F87	14.67	3	Yes	No	0	6	0	1
L:L:?1	R:R:L138	16.67	3	Yes	No	0	6	0	1
L:L:?1	R:R:V141	4.22	3	Yes	No	0	5	0	1
L:L:?1	R:R:F142	23.29	3	Yes	No	0	4	0	1
L:L:?1	R:R:L158	6.86	3	Yes	No	0	1	0	1
L:L:?1	R:R:L171	3.92	3	Yes	No	0	5	0	1
L:L:?1	R:R:R183	7.74	3	Yes	No	0	6	0	1
R:R:L158	R:R:P80	4.93	3	No	No	1	7	1	1
R:R:F87	R:R:H86	10.18	0	No	No	6	6	1	2
R:R:F87	R:R:Y240	6.19	0	No	No	6	8	1	2
R:R:L186	R:R:V141	4.47	0	No	No	6	5	2	1
R:R:E145	R:R:F142	7	0	No	No	4	4	2	1
R:R:E145	R:R:W174	17.45	0	No	Yes	4	4	2	2
R:R:L171	R:R:W174	6.83	0	No	Yes	5	4	1	2
R:R:N244	R:R:R183	13.26	0	No	No	7	6	2	1
R:R:R183	R:R:R258	15.99	0	No	No	6	7	1	2
R:R:R258	R:R:Y240	7.2	4	No	No	7	8	2	2
L:L:?1	R:R:A83	2.23	3	Yes	No	0	6	0	1
R:R:G139	R:R:L138	1.71	0	No	No	4	6	2	1
R:R:A182	R:R:V141	1.7	0	No	No	4	5	2	1
R:R:A146	R:R:L158	1.58	0	No	No	3	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8EJC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	252
Number of Links	257
Number of Hubs	29
Number of Links mediated by Hubs	116
Number of Communities	5
Number of Nodes involved in Communities	24
Number of Links involved in Communities	27

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	51165
Length Of Smallest Path	3
Average Path Length	18.3228
Length of Longest Path	35
Minimum Path Strength	1.165
Average Path Strength	6.67696
Maximum Path Strength	19.98
Minimum Path Correlation	0.7
Average Path Correlation	0.924081
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	39.7626
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.6832
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • response to lipid • response to fatty acid • response to chemical • response to oxygen-containing compound • multicellular organismal process • interleukin-1 production • negative regulation of biological process • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cell communication • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	2YB
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	2YB
Name	Fasiglifam
Synonyms	Fasiglifam
Identifier
Formula	C29 H32 O7 S
Molecular Weight	524.625
SMILES
PubChem	24857286
Formal Charge	0
Total Atoms	69
Total Chiral Atoms	1
Total Bonds	72
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O14842
Sequence	>8EJC_nogp_Chain_R D L P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R L T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S G A W P L P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F P L G Y Q A F R R P C Y S W G V C A A I W A L V L C H L G L V F G L E A P G T S L G I N T P V N G S P V C L E A W D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R S G L T H R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y P N L G G S W R K L G L I T G A W S V V L N P L V T G Y L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4PHU	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Fasiglifam	-	2.33	2014-07-16	doi.org/10.1038/nature13494
	5TZR	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666	-	2.2	2017-06-07	doi.org/10.1038/nsmb.3417
	5TZY	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666; AP8	-	3.22	2017-06-07	doi.org/10.1038/nsmb.3417
	5KW2	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	PubChem 133053953	-	2.76	2018-05-02	doi.org/10.1038/s41467-017-01240-w
	8EIT	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EIT (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8T3V	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3V (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384
	9K1C	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Doconexent	Gi1/β1/γ2	3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1C (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Doconexent		3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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