psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L3	R:R:S8	3	No	No	0	7	3
2	R:R:K259	R:R:L3	7.05	Yes	No	0	3	7
3	R:R:L7	R:R:P4	6.57	No	No	0	7	6
4	R:R:A68	R:R:P5	3.74	No	No	0	3	7
5	R:R:A66	R:R:S8	3.42	No	No	0	6	3
6	R:R:F9	R:R:G10	3.01	No	No	0	6	5
7	R:R:F9	R:R:V13	7.87	No	No	0	6	6
8	R:R:F9	R:R:L67	4.87	No	No	0	6	4
9	R:R:L11	R:R:Y12	3.52	No	Yes	1	5	9
10	R:R:I263	R:R:L11	5.71	Yes	No	1	6	5
11	R:R:K62	R:R:Y12	4.78	Yes	Yes	1	7	9
12	R:R:A63	R:R:Y12	4	No	Yes	0	7	9
13	R:R:K259	R:R:Y12	4.78	Yes	Yes	1	3	9
14	R:R:I263	R:R:Y12	3.63	Yes	Yes	1	6	9
15	R:R:A266	R:R:Y12	4	No	Yes	0	6	9
16	R:R:F16	R:R:F20	6.43	Yes	Yes	2	6	5
17	R:R:F16	R:R:T56	6.49	Yes	Yes	2	6	6
18	R:R:F16	R:R:L59	4.87	Yes	No	0	6	9
19	R:R:F16	R:R:P60	2.89	Yes	No	0	6	9
20	R:R:G19	R:R:V270	3.68	No	No	0	8	6
21	R:R:F20	R:R:P21	2.89	Yes	No	0	5	5
22	R:R:F20	R:R:V24	5.24	Yes	No	0	5	3
23	R:R:F20	R:R:T56	6.49	Yes	Yes	2	5	6
24	R:R:D52	R:R:N23	9.42	No	Yes	2	9	9
25	R:R:N23	R:R:T56	2.92	Yes	Yes	2	9	6
26	R:R:N23	R:R:V269	4.43	Yes	Yes	2	9	7
27	R:R:N23	R:R:P273	4.89	Yes	No	0	9	9
28	R:R:G49	R:R:I27	3.53	No	No	0	8	7
29	R:R:I27	R:R:L53	5.71	No	No	0	7	7
30	R:R:R28	R:R:T31	3.88	No	No	0	2	1
31	R:R:A30	R:R:L46	3.15	No	No	0	6	6
32	R:R:H33	R:R:L42	3.86	No	Yes	0	4	7
33	R:R:H33	R:R:Y278	3.27	No	No	0	4	7
34	R:R:A34	R:R:L42	3.15	No	Yes	0	5	7
35	R:R:R37	R:R:T39	3.88	No	No	0	4	7
36	R:R:R118	R:R:R37	4.26	No	No	0	8	4
37	R:R:L38	R:R:P120	4.93	No	No	0	5	4
38	R:R:P40	R:R:T39	3.5	No	No	0	7	7
39	R:R:L42	R:R:T39	8.84	Yes	No	0	7	7
40	R:R:P40	R:R:Y114	2.78	No	No	3	7	6
41	R:R:P40	W:W:?1	4.99	No	Yes	3	7	0
42	R:R:L100	R:R:S41	4.5	No	No	0	8	7
43	R:R:S41	R:R:Y278	5.09	No	No	0	7	7
44	R:R:S123	R:R:V43	4.85	No	No	0	8	7
45	R:R:V43	R:R:W124	17.16	No	No	0	7	4
46	R:R:A99	R:R:Y44	5.34	No	Yes	0	6	7
47	R:R:L100	R:R:Y44	4.69	No	Yes	0	8	7
48	R:R:S123	R:R:Y44	6.36	No	Yes	0	8	7
49	R:R:C127	R:R:Y44	2.69	No	Yes	0	7	7
50	R:R:Y44	W:W:?1	9.79	Yes	Yes	0	7	0
51	R:R:F96	R:R:N47	9.67	Yes	No	4	6	9
52	R:R:C127	R:R:N47	4.72	No	No	0	7	9
53	R:R:N47	R:R:W131	5.65	No	No	4	9	9
54	R:R:D52	R:R:L48	4.07	No	No	0	9	9
55	R:R:L48	R:R:N272	6.87	No	No	0	9	9
56	R:R:F96	R:R:S51	3.96	Yes	No	0	6	8
57	R:R:D52	R:R:V269	4.38	No	Yes	2	9	7
58	R:R:L53	R:R:T56	4.42	No	Yes	0	7	6
59	R:R:L54	R:R:P89	3.28	No	No	0	7	8
60	R:R:H86	R:R:L55	2.57	No	No	0	6	7
61	R:R:L55	R:R:P89	8.21	No	No	0	7	8
62	R:R:L55	R:R:V269	10.43	No	Yes	0	7	7
63	R:R:T56	R:R:V269	3.17	Yes	Yes	2	6	7
64	R:R:F82	R:R:S58	6.61	Yes	No	0	5	7
65	R:R:A85	R:R:S58	3.42	No	No	0	5	7
66	R:R:H86	R:R:S58	4.18	No	No	0	6	7
67	R:R:E65	R:R:L61	10.6	Yes	Yes	1	7	6
68	R:R:L61	R:R:W72	5.69	Yes	Yes	1	6	9
69	R:R:L61	R:R:L74	8.3	Yes	Yes	1	6	7
70	R:R:F82	R:R:L61	17.05	Yes	Yes	1	5	6
71	R:R:E65	R:R:K62	13.5	Yes	Yes	1	7	7
72	R:R:F82	R:R:K62	7.44	Yes	Yes	1	5	7
73	R:R:H86	R:R:K62	7.86	No	Yes	0	6	7
74	R:R:E172	R:R:K62	6.75	No	Yes	0	6	7
75	R:R:E65	R:R:F82	8.16	Yes	Yes	1	7	5
76	R:R:E65	R:R:V169	7.13	Yes	Yes	1	7	5
77	R:R:G70	R:R:P73	4.06	No	No	0	6	4
78	R:R:L74	R:R:W72	5.69	Yes	Yes	1	7	9
79	R:R:C79	R:R:W72	9.14	No	Yes	1	9	9
80	R:R:V169	R:R:W72	8.58	Yes	Yes	1	5	9
81	R:R:L74	R:R:P73	4.93	Yes	No	0	7	4
82	R:R:L74	R:R:P75	4.93	Yes	No	0	7	8
83	R:R:L78	R:R:P75	4.93	No	No	0	5	8
84	R:R:C170	R:R:C79	7.28	No	No	1	9	9
85	R:R:F142	R:R:P80	7.22	Yes	Yes	1	4	7
86	R:R:L158	R:R:P80	4.93	No	Yes	1	1	7
87	R:R:F82	R:R:V169	2.62	Yes	Yes	1	5	5
88	R:R:A83	R:R:F87	2.77	No	No	0	6	6
89	R:R:F87	R:R:L171	8.53	No	No	0	6	5
90	R:R:F88	R:R:P89	5.78	Yes	No	0	5	8
91	R:R:A92	R:R:F88	6.93	No	Yes	0	6	5
92	R:R:F88	R:R:W131	12.03	Yes	No	0	5	9
93	R:R:F88	R:R:V134	5.24	Yes	No	0	5	7
94	R:R:L190	R:R:Y91	19.93	No	No	0	6	8
95	R:R:Y240	R:R:Y91	4.96	No	No	0	8	8
96	R:R:A92	R:R:F96	2.77	No	Yes	0	6	6
97	R:R:F96	R:R:W131	9.02	Yes	No	4	6	9
98	R:R:L233	R:R:L97	4.15	No	No	0	9	8
99	R:R:L100	R:R:R104	12.15	No	No	0	8	9
100	R:R:S101	R:R:T198	6.4	No	No	0	9	8
101	R:R:A102	W:W:?1	3.59	No	Yes	0	6	0
102	R:R:G103	R:R:L106	3.42	No	No	3	8	7
103	R:R:G103	W:W:?1	3.9	No	Yes	3	8	0
104	R:R:A109	R:R:Y105	5.34	No	Yes	5	8	7
105	R:R:F110	R:R:Y105	3.09	No	Yes	5	6	7
106	R:R:F200	R:R:Y105	5.16	No	Yes	0	4	7
107	R:R:C201	R:R:Y105	6.72	No	Yes	0	7	7
108	R:R:G204	R:R:Y105	2.9	No	Yes	0	4	7
109	R:R:L106	W:W:?1	5.26	No	Yes	3	7	0
110	R:R:G107	R:R:Y114	8.69	No	No	0	8	6
111	R:R:A109	R:R:F110	4.16	No	No	5	8	6
112	R:R:Y114	W:W:?1	5.34	No	Yes	3	6	0
113	R:R:R119	R:R:Y122	5.14	No	No	0	5	3
114	R:R:I130	W:W:?1	6.5	No	Yes	0	6	0
115	R:R:L190	R:R:V134	2.98	No	No	0	6	7
116	R:R:H137	R:R:V141	2.77	No	No	6	5	5
117	R:R:H137	R:R:L186	6.43	No	No	6	5	6
118	R:R:H137	R:R:L189	7.71	No	No	0	5	5
119	R:R:E145	R:R:V141	9.98	No	No	0	4	5
120	R:R:L186	R:R:V141	10.43	No	No	6	6	5
121	R:R:A146	R:R:F142	5.55	No	Yes	0	3	4
122	R:R:F142	R:R:L158	7.31	Yes	No	1	4	1
123	R:R:A179	R:R:E145	7.54	No	No	0	4	4
124	R:R:A182	R:R:E145	3.02	No	No	0	4	4
125	R:R:D152	R:R:P147	11.27	Yes	Yes	7	4	3
126	R:R:P147	R:R:T156	6.99	Yes	No	7	3	1
127	R:R:N161	R:R:P147	11.4	No	Yes	0	3	3
128	R:R:P147	R:R:W174	4.05	Yes	Yes	0	3	4
129	R:R:D152	R:R:G148	3.35	Yes	No	0	4	4
130	R:R:D152	R:R:T156	5.78	Yes	No	7	4	1
131	R:R:I160	R:R:S157	10.84	No	No	0	2	2
132	R:R:I160	R:R:T162	3.04	No	Yes	0	2	2
133	R:R:P168	R:R:T162	5.25	No	Yes	0	4	2
134	R:R:G166	R:R:N165	3.39	No	No	0	4	4
135	R:R:A173	R:R:P168	3.74	No	No	0	5	4
136	R:R:E172	R:R:V169	17.11	No	Yes	0	6	5
137	R:R:L171	R:R:W174	4.56	No	Yes	0	5	4
138	R:R:L171	R:R:R183	9.72	No	No	0	5	6
139	R:R:S178	R:R:W174	11.12	No	Yes	0	1	4
140	R:R:A179	R:R:W174	5.19	No	Yes	0	4	4
141	R:R:D175	R:R:P176	3.22	No	No	0	6	1
142	R:R:D175	R:R:S178	2.94	No	No	0	6	1
143	R:R:G180	R:R:P181	4.06	No	No	0	3	4
144	R:R:F248	R:R:P181	5.78	No	No	0	5	4
145	R:R:N244	R:R:R183	7.23	Yes	No	8	7	6
146	R:R:R183	R:R:R258	11.73	No	No	8	6	7
147	R:R:F184	R:R:L188	15.83	No	No	0	4	4
148	R:R:F184	R:R:V245	5.24	No	No	0	4	5
149	R:R:F184	R:R:F248	33.22	No	No	0	4	5
150	R:R:L186	R:R:L190	2.77	No	No	0	6	6
151	R:R:N241	R:R:S187	5.96	No	No	0	9	5
152	R:R:N244	R:R:S187	4.47	Yes	No	0	7	5
153	R:R:F192	R:R:L188	4.87	No	No	0	4	4
154	R:R:F191	R:R:L195	10.96	Yes	No	0	9	6
155	R:R:F191	R:R:V237	9.18	Yes	No	0	9	8
156	R:R:F191	R:R:G238	3.01	Yes	No	0	9	4
157	R:R:F191	R:R:N241	18.12	Yes	No	0	9	9
158	R:R:L193	R:R:P194	3.28	No	No	0	4	9
159	R:R:P194	W:W:?1	4.99	No	Yes	0	9	0
160	R:R:L195	R:R:L233	2.77	No	No	0	6	9
161	R:R:L195	R:R:L234	4.15	No	No	0	6	5
162	R:R:L230	R:R:T198	2.95	No	No	0	8	8
163	R:R:L206	R:R:Y202	12.89	No	Yes	0	5	8
164	R:R:A226	R:R:Y202	2.67	No	Yes	0	7	8
165	R:R:G227	R:R:Y202	2.9	No	Yes	0	4	8
166	R:R:G204	R:R:R207	3	No	No	0	4	4
167	R:R:G213	R:R:S212	3.71	No	No	0	4	5
168	R:R:L214	R:R:S212	4.5	No	No	0	3	5
169	R:R:K219	R:R:L214	4.23	No	No	0	6	3
170	R:R:R218	R:R:T215	2.59	No	No	0	5	3
171	R:R:R221	R:R:W224	8	No	No	9	7	5
172	R:R:R221	R:R:V225	3.92	No	No	9	7	7
173	R:R:V225	R:R:W224	3.68	No	No	9	7	5
174	R:R:L231	R:R:L235	5.54	No	No	0	5	5
175	R:R:L271	R:R:T232	4.42	No	No	0	6	6
176	R:R:N272	R:R:T232	5.85	No	No	0	9	6
177	R:R:T232	R:R:V275	7.93	No	No	0	6	7
178	R:R:L233	R:R:V237	2.98	No	No	0	9	8
179	R:R:C236	R:R:S268	3.44	No	No	0	8	9
180	R:R:C236	R:R:L271	4.76	No	No	0	8	6
181	R:R:G238	R:R:P239	4.06	No	No	0	4	9
182	R:R:P239	R:R:T264	8.74	No	No	0	9	5
183	R:R:N244	R:R:Y240	20.93	Yes	No	0	7	8
184	R:R:N244	R:R:S243	4.47	Yes	No	0	7	5
185	R:R:N244	R:R:R258	4.82	Yes	No	8	7	7
186	R:R:A246	R:R:L253	4.73	No	Yes	0	5	3
187	R:R:L253	R:R:S247	4.5	Yes	No	0	3	6
188	R:R:L249	R:R:Y250	3.52	No	Yes	0	4	2
189	R:R:L253	R:R:Y250	4.69	Yes	Yes	0	3	2
190	R:R:L253	R:R:W257	5.69	Yes	No	0	3	5
191	R:R:K259	R:R:L262	5.64	Yes	No	0	3	5
192	R:R:I263	R:R:K259	11.63	Yes	Yes	1	6	3
193	R:R:I263	R:R:W267	7.05	Yes	No	0	6	4
194	R:R:T276	R:R:V275	6.35	No	No	0	7	7
195	R:R:F88	R:R:L138	2.44	Yes	No	0	5	6
196	R:R:L90	R:R:Y240	2.34	No	No	0	7	8
197	R:R:L230	R:R:Y202	2.34	No	Yes	0	8	8
198	R:R:N252	R:R:Y250	2.33	No	Yes	0	1	2
199	R:R:F191	R:R:F192	2.14	Yes	No	0	9	4
200	R:R:R217	R:R:R221	2.13	No	No	0	3	7
201	R:R:G93	R:R:G94	2.11	No	No	0	9	8
202	R:R:G94	R:R:G95	2.11	No	No	0	8	5
203	R:R:G148	R:R:G149	2.11	No	No	0	4	3
204	R:R:G227	R:R:G228	2.11	No	No	0	4	5
205	R:R:G254	R:R:G255	2.11	No	No	0	6	5
206	R:R:C170	R:R:G159	1.96	No	No	0	9	4
207	R:R:P4	R:R:P5	1.95	No	No	0	6	7
208	R:R:A26	R:R:G277	1.95	No	No	0	9	4
209	R:R:A32	R:R:G29	1.95	No	No	0	3	7
210	R:R:A92	R:R:G93	1.95	No	No	0	6	9
211	R:R:A98	R:R:G95	1.95	No	No	0	7	5
212	R:R:A116	R:R:G113	1.95	No	No	0	3	4
213	R:R:A128	R:R:G125	1.95	No	No	0	4	1
214	R:R:C79	R:R:P80	1.88	No	Yes	1	9	7
215	R:R:C170	R:R:P80	1.88	No	Yes	1	9	7
216	R:R:G166	R:R:S167	1.86	No	No	0	4	3
217	R:R:G204	R:R:V203	1.84	No	No	0	4	3
218	R:R:G228	R:R:V275	1.84	No	No	0	5	7
219	R:R:G166	R:R:T162	1.82	No	Yes	0	4	2
220	R:R:G261	R:R:T264	1.82	No	No	0	6	5
221	R:R:A102	R:R:C201	1.81	No	No	0	6	7
222	R:R:A108	R:R:C205	1.81	No	No	0	8	7
223	R:R:A108	R:R:A208	1.79	No	No	0	8	5
224	R:R:A109	R:R:A208	1.79	No	No	0	8	5
225	R:R:P5	R:R:S8	1.78	No	No	0	7	3
226	R:R:G159	R:R:I160	1.76	No	No	0	4	2
227	R:R:P163	R:R:T162	1.75	No	Yes	0	4	2
228	R:R:G265	R:R:L90	1.71	No	No	0	8	7
229	R:R:G113	R:R:L112	1.71	No	No	0	4	6
230	R:R:G139	R:R:L138	1.71	No	No	0	4	6
231	R:R:G228	R:R:L231	1.71	No	No	0	5	5
232	R:R:G277	R:R:L279	1.71	No	No	0	4	5
233	R:R:G19	R:R:N23	1.7	No	Yes	0	8	9
234	R:R:L112	R:R:P111	1.64	No	No	0	6	9
235	R:R:C201	R:R:I197	1.64	No	No	0	7	6
236	R:R:T56	R:R:V57	1.59	Yes	No	0	6	4
237	R:R:A30	R:R:L42	1.58	No	Yes	0	6	7
238	R:R:A34	R:R:L38	1.58	No	No	0	5	5
239	R:R:A34	R:R:L46	1.58	No	No	0	5	6
240	R:R:A223	R:R:L206	1.58	No	No	0	5	5
241	R:R:A222	R:R:L209	1.58	No	No	0	8	8
242	R:R:I130	R:R:V126	1.54	No	No	0	6	5
243	R:R:I27	R:R:T31	1.52	No	No	0	7	1
244	R:R:F117	R:R:G113	1.51	No	No	0	4	4
245	R:R:F142	R:R:G143	1.51	Yes	No	0	4	3
246	R:R:G29	R:R:R28	1.5	No	No	0	7	2
247	R:R:L18	R:R:V270	1.49	No	No	0	6	6
248	R:R:L74	R:R:V64	1.49	Yes	No	0	7	4
249	R:R:L78	R:R:V81	1.49	No	No	0	5	5
250	R:R:N165	R:R:V164	1.48	No	No	0	4	2
251	R:R:D2	R:R:S256	1.47	No	No	0	7	1
252	R:R:G277	R:R:Y278	1.45	No	No	0	4	7
253	R:R:F110	R:R:P111	1.44	No	No	0	6	9
254	R:R:P120	R:R:R119	1.44	No	No	0	4	5
255	R:R:G125	R:R:W124	1.41	No	No	0	1	4
256	R:R:G149	R:R:W150	1.41	No	No	0	3	4
257	R:R:K219	R:R:L209	1.41	No	No	0	6	8
258	R:R:P251	R:R:Y250	1.39	No	Yes	0	2	2
259	R:R:L22	R:R:L274	1.38	No	No	0	7	6
260	R:R:L133	R:R:L189	1.38	No	No	0	5	5
261	R:R:L144	R:R:L151	1.38	No	No	0	3	5
262	R:R:R104	R:R:V225	1.31	No	No	0	9	7
263	R:R:A76	R:R:W72	1.3	No	Yes	0	3	9
264	R:R:R217	R:R:T215	1.29	No	No	0	3	3
265	R:R:D152	R:R:H153	1.26	Yes	No	0	4	4
266	R:R:S243	R:R:W257	1.24	No	No	0	5	5
267	R:R:L36	R:R:R37	1.21	No	No	0	4	4
268	R:R:Q115	R:R:R118	1.17	No	No	0	5	8
269	R:R:L151	R:R:W150	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y12	4.11833	6	1	9
2	R:R:F16	5.17	4	2	6
3	R:R:F20	5.2625	4	2	5
4	R:R:N23	4.672	5	2	9
5	R:R:L42	4.3575	4	0	7
6	R:R:Y44	5.774	5	0	7
7	R:R:T56	4.18	6	2	6
8	R:R:L61	10.41	4	1	6
9	R:R:K62	8.066	5	1	7
10	R:R:E65	9.8475	4	1	7
11	R:R:W72	6.08	5	1	9
12	R:R:L74	5.068	5	1	7
13	R:R:P80	3.9775	4	1	7
14	R:R:F82	8.376	5	1	5
15	R:R:F88	6.484	5	0	5
16	R:R:F96	6.355	4	4	6
17	R:R:Y105	4.642	5	5	7
18	R:R:F142	5.3975	4	1	4
19	R:R:P147	8.4275	4	7	3
20	R:R:D152	5.415	4	7	4
21	R:R:T162	2.965	4	0	2
22	R:R:V169	8.86	4	1	5
23	R:R:W174	6.23	4	0	4
24	R:R:F191	8.682	5	0	9
25	R:R:Y202	5.2	4	0	8
26	R:R:N244	8.384	5	8	7
27	R:R:Y250	2.9825	4	0	2
28	R:R:L253	4.9025	4	0	3
29	R:R:K259	7.275	4	1	3
30	R:R:I263	7.005	4	1	6
31	R:R:V269	5.6025	4	2	7
32	W:W:?1	5.545	8	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K62	R:R:Y12	13.1606	4.78	Yes	Yes	1	7	9
2	R:R:T56	R:R:V269	15.1637	3.17	Yes	Yes	2	6	7
3	R:R:L55	R:R:V269	38.8879	10.43	No	Yes	0	7	7
4	R:R:H86	R:R:L55	100	2.57	No	No	0	6	7
5	R:R:H86	R:R:K62	72.7014	7.86	No	Yes	0	6	7
6	R:R:D52	R:R:V269	19.7863	4.38	No	Yes	2	9	7
7	R:R:P40	R:R:T39	13.9135	3.5	No	No	0	7	7
8	R:R:P40	W:W:?1	14.7432	4.99	No	Yes	3	7	0
9	R:R:Y44	W:W:?1	38.5896	9.79	Yes	Yes	0	7	0
10	R:R:C127	R:R:Y44	55.0347	2.69	No	Yes	0	7	7
11	R:R:C127	R:R:N47	55.7393	4.72	No	No	0	7	9
12	R:R:N47	R:R:W131	55.1455	5.65	No	No	4	9	9
13	R:R:F88	R:R:W131	57.5492	12.03	Yes	No	0	5	9
14	R:R:F88	R:R:P89	93.9027	5.78	Yes	No	0	5	8
15	R:R:L55	R:R:P89	94.4198	8.21	No	No	0	7	8
16	R:R:L100	R:R:Y44	13.5044	4.69	No	Yes	0	8	7
17	R:R:D52	R:R:L48	19.9142	4.07	No	No	0	9	9
18	R:R:L48	R:R:N272	18.9056	6.87	No	No	0	9	9
19	R:R:F82	R:R:K62	28.5686	7.44	Yes	Yes	1	5	7
20	R:R:F82	R:R:S58	26.6593	6.61	Yes	No	0	5	7
21	R:R:H86	R:R:S58	27.452	4.18	No	No	0	6	7
22	R:R:E65	R:R:K62	28.6567	13.5	Yes	Yes	1	7	7
23	R:R:E65	R:R:L61	16.141	10.6	Yes	Yes	1	7	6
24	R:R:F82	R:R:L61	31.012	17.05	Yes	Yes	1	5	6
25	R:R:L61	R:R:W72	33.626	5.69	Yes	Yes	1	6	9
26	R:R:E65	R:R:V169	12.0866	7.13	Yes	Yes	1	7	5
27	R:R:V169	R:R:W72	45.2608	8.58	Yes	Yes	1	5	9
28	R:R:F82	R:R:V169	23.1901	2.62	Yes	Yes	1	5	5
29	R:R:E172	R:R:K62	12.5554	6.75	No	Yes	0	6	7
30	R:R:E172	R:R:V169	12.1122	17.11	No	Yes	0	6	5
31	R:R:L61	R:R:L74	11.8906	8.3	Yes	Yes	1	6	7
32	R:R:C79	R:R:W72	71.4399	9.14	No	Yes	1	9	9
33	R:R:C170	R:R:C79	47.7696	7.28	No	No	1	9	9
34	R:R:F142	R:R:P80	11.8053	7.22	Yes	Yes	1	4	7
35	R:R:C79	R:R:P80	19.7125	1.88	No	Yes	1	9	7
36	R:R:N244	R:R:Y240	33.1316	20.93	Yes	No	0	7	8
37	R:R:Y240	R:R:Y91	35.4501	4.96	No	No	0	8	8
38	R:R:L190	R:R:Y91	36.2172	19.93	No	No	0	6	8
39	R:R:L190	R:R:V134	55.8501	2.98	No	No	0	6	7
40	R:R:F88	R:R:V134	56.5604	5.24	Yes	No	0	5	7
41	R:R:F191	R:R:N241	19.3232	18.12	Yes	No	0	9	9
42	R:R:N241	R:R:S187	20.2836	5.96	No	No	0	9	5
43	R:R:N244	R:R:S187	21.2382	4.47	Yes	No	0	7	5
44	R:R:N272	R:R:T232	17.8912	5.85	No	No	0	9	6
45	R:R:T232	R:R:V275	13.7771	7.93	No	No	0	6	7
46	R:R:G228	R:R:V275	11.6803	1.84	No	No	0	5	7
47	R:R:A102	W:W:?1	18.1469	3.59	No	Yes	0	6	0
48	R:R:C201	R:R:Y105	15.2318	6.72	No	Yes	0	7	7
49	R:R:A102	R:R:C201	17.1809	1.81	No	No	0	6	7
50	R:R:L186	R:R:L190	20.0108	2.77	No	No	0	6	6
51	R:R:L186	R:R:V141	16.0586	10.43	No	No	6	6	5
52	R:R:E145	R:R:V141	15.3966	9.98	No	No	0	4	5
53	R:R:A179	R:R:E145	13.8453	7.54	No	No	0	4	4
54	R:R:P147	R:R:W174	10.3421	4.05	Yes	Yes	0	3	4
55	R:R:A179	R:R:W174	13.064	5.19	No	Yes	0	4	4
56	R:R:G159	R:R:I160	39.9534	1.76	No	No	0	4	2
57	R:R:C170	R:R:G159	43.9482	1.96	No	No	0	9	4
58	R:R:I160	R:R:T162	31.9468	3.04	No	Yes	0	2	2
59	R:R:G166	R:R:T162	15.8654	1.82	No	Yes	0	4	2

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P40	R:R:T39	3.5	3	No	No	7	7	1	2
R:R:P40	R:R:Y114	2.78	3	No	No	7	6	1	1
R:R:P40	W:W:?1	4.99	3	No	Yes	7	0	1	0
R:R:A99	R:R:Y44	5.34	0	No	Yes	6	7	2	1
R:R:L100	R:R:Y44	4.69	0	No	Yes	8	7	2	1
R:R:S123	R:R:Y44	6.36	0	No	Yes	8	7	2	1
R:R:C127	R:R:Y44	2.69	0	No	Yes	7	7	2	1
R:R:Y44	W:W:?1	9.79	0	Yes	Yes	7	0	1	0
R:R:A102	W:W:?1	3.59	0	No	Yes	6	0	1	0
R:R:G103	R:R:L106	3.42	3	No	No	8	7	1	1
R:R:G103	W:W:?1	3.9	3	No	Yes	8	0	1	0
R:R:L106	W:W:?1	5.26	3	No	Yes	7	0	1	0
R:R:G107	R:R:Y114	8.69	0	No	No	8	6	2	1
R:R:Y114	W:W:?1	5.34	3	No	Yes	6	0	1	0
R:R:I130	W:W:?1	6.5	0	No	Yes	6	0	1	0
R:R:L193	R:R:P194	3.28	0	No	No	4	9	2	1
R:R:P194	W:W:?1	4.99	0	No	Yes	9	0	1	0
R:R:A102	R:R:C201	1.81	0	No	No	6	7	1	2
R:R:I130	R:R:V126	1.54	0	No	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K1C_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.57
Number of Linked Nodes	248
Number of Links	269
Number of Hubs	32
Number of Links mediated by Hubs	120
Number of Communities	9
Number of Nodes involved in Communities	45
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	55047
Length Of Smallest Path	3
Average Path Length	16.1165
Length of Longest Path	30
Minimum Path Strength	1.26
Average Path Strength	6.35881
Maximum Path Strength	24.525
Minimum Path Correlation	0.7
Average Path Correlation	0.923658
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	43.9925
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.3506
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • response to lipid • response to fatty acid • response to chemical • response to oxygen-containing compound • multicellular organismal process • interleukin-1 production • negative regulation of biological process • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • protein localization • positive regulation of cell communication • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • cellular macromolecule localization • positive regulation of insulin secretion • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to ketone • response to prostaglandin • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HXA
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	HXA
Name	Doconexent
Synonyms	DHA
Identifier
Formula	C22 H32 O2
Molecular Weight	328.488
SMILES
PubChem	445580
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O14842
Sequence	>9K1C_nogp_Chain_R M D L P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R L T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S G A W P L P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F P L G Y Q A F R R P C Y S W G V C A A I W A L V L C H L G L V F G L E A P G G W L D H S N T S L G I N T P V N G S P V C L E A W D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R S G L T H R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y P N L G G S W R K L G L I T G A W S V V L N P L V T G Y L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K1C	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA	Gi1/β1/γ2	3.2	2024-12-11	10.1016/j.celrep.2024.115024
	9K1C (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA		3.2	2024-12-11	10.1016/j.celrep.2024.115024
	8T3V	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.39	2024-01-24	10.1126/sciadv.adj2384
	8T3V (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.39	2024-01-24	10.1126/sciadv.adj2384
	8EJK	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.4	2023-05-24	10.1073/pnas.2219569120
	8EJK (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3.4	2023-05-24	10.1073/pnas.2219569120
	8EJC	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3	2023-05-24	10.1073/pnas.2219569120
	8EJC (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3	2023-05-24	10.1073/pnas.2219569120
	8EIT	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2023-05-24	10.1073/pnas.2219569120
	8EIT (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		2.8	2023-05-24	10.1073/pnas.2219569120
	5KW2	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	PubChem 133053953	-	2.76	2018-05-02	10.1038/s41467-017-01240-w
	5TZY	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666; PubChem 127053597	-	3.22	2017-06-07	10.1038/nsmb.3417
	5TZR	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666	-	2.2	2017-06-07	10.1038/nsmb.3417
	4PHU	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Fasiglifam	-	2.33	2014-07-16	10.1038/nature13494

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