psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A83	3.59	Yes	No	1	0	6
2	L:L:?1	R:R:V84	20.36	Yes	No	0	0	6
3	L:L:?1	R:R:F87	20.35	Yes	Yes	1	0	6
4	L:L:?1	R:R:L135	9.46	Yes	No	0	0	3
5	L:L:?1	R:R:L138	10.51	Yes	No	0	0	6
6	L:L:?1	R:R:G139	5.2	Yes	No	0	0	4
7	L:L:?1	R:R:F142	13.87	Yes	Yes	1	0	4
8	L:L:?1	R:R:R183	19.37	Yes	Yes	1	0	6
9	L:L:?1	R:R:N244	3.13	Yes	Yes	1	0	7
10	L:L:?1	R:R:R258	8.3	Yes	Yes	1	0	7
11	R:R:L3	R:R:S8	4.5	No	No	0	7	3
12	R:R:K259	R:R:L3	4.23	No	No	0	3	7
13	R:R:L7	R:R:P4	9.85	No	No	0	7	6
14	R:R:F9	R:R:V13	3.93	No	No	0	6	6
15	R:R:F9	R:R:L67	7.31	No	No	0	6	4
16	R:R:I263	R:R:L11	4.28	No	No	0	6	5
17	R:R:L59	R:R:Y12	3.52	No	Yes	0	9	9
18	R:R:K62	R:R:Y12	9.55	Yes	Yes	0	7	9
19	R:R:A63	R:R:Y12	4	No	Yes	0	7	9
20	R:R:I263	R:R:Y12	4.84	No	Yes	0	6	9
21	R:R:A15	R:R:L59	4.73	No	No	0	7	9
22	R:R:F16	R:R:F20	6.43	No	No	0	6	5
23	R:R:F16	R:R:P60	15.89	No	No	0	6	9
24	R:R:L18	R:R:V270	5.96	No	No	0	6	6
25	R:R:G19	R:R:V269	3.68	No	Yes	0	8	7
26	R:R:F20	R:R:T56	5.19	No	No	0	5	6
27	R:R:L22	R:R:P273	4.93	No	Yes	0	7	9
28	R:R:D52	R:R:N23	13.46	Yes	Yes	2	9	9
29	R:R:N23	R:R:T56	7.31	Yes	No	2	9	6
30	R:R:N23	R:R:V269	2.96	Yes	Yes	2	9	7
31	R:R:N23	R:R:P273	4.89	Yes	Yes	2	9	9
32	R:R:I27	R:R:L53	4.28	No	No	0	7	7
33	R:R:A30	R:R:L46	3.15	No	No	0	6	6
34	R:R:H33	R:R:L42	3.86	No	Yes	0	4	7
35	R:R:R37	R:R:T39	6.47	No	No	0	4	7
36	R:R:R118	R:R:R37	8.53	No	No	0	8	4
37	R:R:L38	R:R:P120	3.28	No	No	0	5	4
38	R:R:P40	R:R:T39	3.5	No	No	0	7	7
39	R:R:L42	R:R:T39	5.9	Yes	No	0	7	7
40	R:R:P40	R:R:Y114	5.56	No	No	0	7	6
41	R:R:S41	R:R:Y278	5.09	No	Yes	0	7	7
42	R:R:L42	R:R:Y278	8.21	Yes	Yes	0	7	7
43	R:R:N47	R:R:V43	4.43	Yes	No	3	9	7
44	R:R:S123	R:R:V43	9.7	Yes	No	0	8	7
45	R:R:V43	R:R:W124	13.48	No	No	3	7	4
46	R:R:A99	R:R:Y44	5.34	No	Yes	0	6	7
47	R:R:L100	R:R:Y44	9.38	No	Yes	0	8	7
48	R:R:S123	R:R:Y44	3.82	Yes	Yes	0	8	7
49	R:R:V126	R:R:Y44	3.79	No	Yes	0	5	7
50	R:R:A45	R:R:Y278	5.34	No	Yes	0	7	7
51	R:R:F96	R:R:N47	12.08	Yes	Yes	3	6	9
52	R:R:N47	R:R:W124	10.17	Yes	No	3	9	4
53	R:R:C127	R:R:N47	7.87	No	Yes	3	7	9
54	R:R:N47	R:R:W131	9.04	Yes	No	0	9	9
55	R:R:L48	R:R:N272	8.24	No	Yes	0	9	9
56	R:R:D52	R:R:V269	5.84	Yes	Yes	2	9	7
57	R:R:D52	R:R:N272	5.39	Yes	Yes	2	9	9
58	R:R:D52	R:R:P273	4.83	Yes	Yes	2	9	9
59	R:R:L54	R:R:P89	3.28	No	No	0	7	8
60	R:R:H86	R:R:L55	3.86	Yes	Yes	0	6	7
61	R:R:L55	R:R:P89	9.85	Yes	No	0	7	8
62	R:R:L55	R:R:L90	4.15	Yes	No	0	7	7
63	R:R:L55	R:R:V269	5.96	Yes	Yes	0	7	7
64	R:R:T56	R:R:V269	4.76	No	Yes	2	6	7
65	R:R:A85	R:R:S58	3.42	No	No	0	5	7
66	R:R:H86	R:R:S58	5.58	Yes	No	0	6	7
67	R:R:L59	R:R:V269	4.47	No	Yes	0	9	7
68	R:R:F82	R:R:L61	6.09	No	No	0	5	6
69	R:R:E65	R:R:K62	5.4	No	Yes	0	7	7
70	R:R:F82	R:R:K62	7.44	No	Yes	1	5	7
71	R:R:H86	R:R:K62	5.24	Yes	Yes	1	6	7
72	R:R:E65	R:R:G70	3.27	No	No	0	7	6
73	R:R:E172	R:R:E65	6.34	No	No	0	6	7
74	R:R:L74	R:R:W72	12.53	No	Yes	0	7	9
75	R:R:C79	R:R:W72	6.53	Yes	Yes	5	9	9
76	R:R:I160	R:R:W72	4.7	Yes	Yes	5	2	9
77	R:R:L74	R:R:P75	3.28	No	No	0	7	8
78	R:R:A76	R:R:I160	3.25	No	Yes	0	3	2
79	R:R:C79	R:R:P80	3.77	Yes	No	0	9	7
80	R:R:C79	R:R:I160	11.46	Yes	Yes	5	9	2
81	R:R:C170	R:R:C79	7.28	No	Yes	0	9	9
82	R:R:G159	R:R:P80	4.06	No	No	0	4	7
83	R:R:F82	R:R:H86	6.79	No	Yes	1	5	6
84	R:R:A83	R:R:F142	4.16	No	Yes	1	6	4
85	R:R:F87	R:R:H86	3.39	Yes	Yes	1	6	6
86	R:R:F87	R:R:Y240	5.16	Yes	Yes	1	6	8
87	R:R:F87	R:R:R258	5.34	Yes	Yes	1	6	7
88	R:R:F88	R:R:P89	5.78	Yes	No	0	5	8
89	R:R:A92	R:R:F88	8.32	No	Yes	0	6	5
90	R:R:F88	R:R:W131	5.01	Yes	No	0	5	9
91	R:R:F88	R:R:V134	5.24	Yes	No	0	5	7
92	R:R:F88	R:R:L135	4.87	Yes	No	0	5	3
93	R:R:L90	R:R:Y240	11.72	No	Yes	0	7	8
94	R:R:L138	R:R:Y91	5.86	No	Yes	0	6	8
95	R:R:L186	R:R:Y91	10.55	No	Yes	0	6	8
96	R:R:L190	R:R:Y91	4.69	No	Yes	0	6	8
97	R:R:Y240	R:R:Y91	9.93	Yes	Yes	1	8	8
98	R:R:N241	R:R:Y91	3.49	Yes	Yes	1	9	8
99	R:R:N244	R:R:Y91	3.49	Yes	Yes	1	7	8
100	R:R:G95	R:R:I130	3.53	No	No	0	5	6
101	R:R:C127	R:R:F96	4.19	No	Yes	3	7	6
102	R:R:F96	R:R:I130	8.79	Yes	No	0	6	6
103	R:R:A229	R:R:L97	3.15	No	No	0	8	8
104	R:R:L97	R:R:T232	2.95	No	No	2	8	6
105	R:R:L97	R:R:N272	4.12	No	Yes	2	8	9
106	R:R:A98	R:R:I197	3.25	No	No	0	7	6
107	R:R:L100	R:R:R104	9.72	No	No	0	8	9
108	R:R:S101	R:R:T198	3.2	No	No	0	9	8
109	R:R:A109	R:R:Y105	6.67	No	Yes	6	8	7
110	R:R:F110	R:R:Y105	5.16	Yes	Yes	6	6	7
111	R:R:F200	R:R:Y105	3.09	No	Yes	0	4	7
112	R:R:C201	R:R:Y105	5.38	No	Yes	0	7	7
113	R:R:G107	R:R:Y114	7.24	No	No	0	8	6
114	R:R:A109	R:R:F110	8.32	No	Yes	6	8	6
115	R:R:Q115	R:R:R118	15.19	No	No	0	5	8
116	R:R:A116	R:R:F117	8.32	No	No	0	3	4
117	R:R:C121	R:R:R119	6.96	No	No	0	4	5
118	R:R:R119	R:R:Y122	6.17	No	No	0	5	3
119	R:R:L190	R:R:V134	8.94	No	No	0	6	7
120	R:R:C136	R:R:L140	3.17	No	No	0	4	7
121	R:R:H137	R:R:S185	8.37	No	No	0	5	5
122	R:R:H137	R:R:L186	9	No	No	0	5	6
123	R:R:H137	R:R:L189	3.86	No	No	0	5	5
124	R:R:A146	R:R:F142	5.55	No	Yes	0	3	4
125	R:R:F142	R:R:G159	4.52	Yes	No	0	4	4
126	R:R:F142	R:R:L171	6.09	Yes	No	0	4	5
127	R:R:L144	R:R:W150	3.42	No	No	0	3	4
128	R:R:E145	R:R:L151	7.95	No	No	0	4	5
129	R:R:E145	R:R:S178	8.62	No	No	0	4	1
130	R:R:A182	R:R:E145	3.02	No	No	0	4	4
131	R:R:A146	R:R:W174	3.89	No	Yes	0	3	4
132	R:R:N161	R:R:P147	8.15	Yes	No	0	3	3
133	R:R:P147	R:R:W174	12.16	No	Yes	0	3	4
134	R:R:D152	R:R:G148	5.03	No	No	0	4	4
135	R:R:L151	R:R:W150	3.42	No	No	0	5	4
136	R:R:D152	R:R:S154	4.42	No	No	0	4	6
137	R:R:S154	R:R:T156	9.59	No	No	0	6	1
138	R:R:N161	R:R:T156	2.92	Yes	No	0	3	1
139	R:R:I160	R:R:S157	3.1	Yes	No	0	2	2
140	R:R:G159	R:R:I160	3.53	No	Yes	0	4	2
141	R:R:N161	R:R:P163	4.89	Yes	No	0	3	4
142	R:R:N161	R:R:V169	4.43	Yes	No	0	3	5
143	R:R:A173	R:R:N161	4.69	No	Yes	0	5	3
144	R:R:N165	R:R:T162	5.85	No	No	0	4	2
145	R:R:E172	R:R:V169	5.7	No	No	0	6	5
146	R:R:D175	R:R:W174	4.47	Yes	Yes	0	6	4
147	R:R:A179	R:R:W174	7.78	No	Yes	1	4	4
148	R:R:R183	R:R:W174	4	Yes	Yes	1	6	4
149	R:R:A177	R:R:D175	3.09	No	Yes	0	1	6
150	R:R:D175	R:R:S178	4.42	Yes	No	0	6	1
151	R:R:A179	R:R:R183	6.91	No	Yes	1	4	6
152	R:R:G180	R:R:P181	4.06	No	No	0	3	4
153	R:R:F248	R:R:P181	8.67	No	No	0	5	4
154	R:R:N244	R:R:R183	8.44	Yes	Yes	1	7	6
155	R:R:R183	R:R:R258	10.66	Yes	Yes	1	6	7
156	R:R:F184	R:R:L188	3.65	No	No	0	4	4
157	R:R:F184	R:R:V245	3.93	No	No	0	4	5
158	R:R:F184	R:R:F248	12.86	No	No	0	4	5
159	R:R:F192	R:R:S187	6.61	No	No	0	4	5
160	R:R:N241	R:R:S187	7.45	Yes	No	0	9	5
161	R:R:F191	R:R:F192	12.86	Yes	No	0	9	4
162	R:R:F191	R:R:L233	4.87	Yes	No	1	9	9
163	R:R:F191	R:R:V237	5.24	Yes	No	1	9	8
164	R:R:F191	R:R:G238	3.01	Yes	No	0	9	4
165	R:R:F191	R:R:N241	18.12	Yes	Yes	1	9	9
166	R:R:L193	R:R:P194	6.57	No	No	0	4	9
167	R:R:L195	R:R:L233	5.54	No	No	0	6	9
168	R:R:L195	R:R:L234	5.54	No	No	0	6	5
169	R:R:L230	R:R:T198	4.42	No	No	0	8	8
170	R:R:L206	R:R:Y202	5.86	No	Yes	0	5	8
171	R:R:G227	R:R:Y202	7.24	No	Yes	0	4	8
172	R:R:L230	R:R:Y202	4.69	No	Yes	0	8	8
173	R:R:K219	R:R:L206	5.64	No	No	0	6	5
174	R:R:R207	R:R:R211	5.33	No	No	0	4	4
175	R:R:A222	R:R:L209	4.73	No	No	0	8	8
176	R:R:A210	R:R:K219	4.82	No	No	0	2	6
177	R:R:G213	R:R:S212	3.71	No	No	0	4	5
178	R:R:L214	R:R:S212	3	No	No	0	3	5
179	R:R:L214	R:R:R217	10.93	No	No	0	3	3
180	R:R:L214	R:R:R218	3.64	No	No	0	3	5
181	R:R:R217	R:R:T215	15.52	No	No	0	3	3
182	R:R:H216	R:R:L220	3.86	No	No	0	2	4
183	R:R:K219	R:R:R218	6.19	No	No	0	6	5
184	R:R:R221	R:R:V225	5.23	No	No	0	7	7
185	R:R:V225	R:R:W224	3.68	No	No	0	7	5
186	R:R:G228	R:R:V275	5.52	No	No	0	5	7
187	R:R:L271	R:R:T232	2.95	Yes	No	0	6	6
188	R:R:N272	R:R:T232	14.62	Yes	No	2	9	6
189	R:R:L233	R:R:V237	2.98	No	No	1	9	8
190	R:R:C236	R:R:S268	5.16	No	No	0	8	9
191	R:R:C236	R:R:L271	6.35	No	Yes	0	8	6
192	R:R:S268	R:R:V237	3.23	No	No	0	9	8
193	R:R:G238	R:R:P239	4.06	No	No	0	4	9
194	R:R:P239	R:R:T264	10.49	No	No	0	9	5
195	R:R:N244	R:R:Y240	5.81	Yes	Yes	1	7	8
196	R:R:L262	R:R:Y240	4.69	No	Yes	0	5	8
197	R:R:N241	R:R:N244	5.45	Yes	Yes	1	9	7
198	R:R:L249	R:R:Y250	8.21	No	No	0	4	2
199	R:R:L253	R:R:Y250	5.86	Yes	No	0	3	2
200	R:R:N252	R:R:P251	3.26	No	No	0	1	2
201	R:R:L253	R:R:W257	6.83	Yes	No	0	3	5
202	R:R:N272	R:R:S268	5.96	Yes	No	0	9	9
203	R:R:L271	R:R:V275	2.98	Yes	No	0	6	7
204	R:R:L274	R:R:V275	2.98	No	No	0	6	7
205	R:R:T276	R:R:Y278	3.75	No	Yes	0	7	7
206	R:R:G204	R:R:Y105	2.9	No	Yes	0	4	7
207	R:R:G265	R:R:Y240	2.9	No	Yes	0	8	8
208	R:R:L38	R:R:L42	2.77	No	Yes	4	5	7
209	R:R:A66	R:R:Y12	2.67	No	Yes	0	6	9
210	R:R:A266	R:R:Y12	2.67	No	Yes	0	6	9
211	R:R:A226	R:R:Y202	2.67	No	Yes	0	7	8
212	R:R:F96	R:R:S51	2.64	Yes	No	0	6	8
213	R:R:R258	R:R:S243	2.64	Yes	No	0	7	5
214	R:R:C236	R:R:W267	2.61	No	No	0	8	4
215	R:R:A14	R:R:W267	2.59	No	No	0	4	4
216	R:R:F110	R:R:L106	2.44	Yes	No	0	6	7
217	R:R:L106	R:R:Y114	2.34	No	No	0	7	6
218	R:R:M1	R:R:W257	2.33	No	No	0	6	5
219	R:R:L78	R:R:W72	2.28	No	Yes	0	5	9
220	R:R:R217	R:R:R221	2.13	No	No	0	3	7
221	R:R:G93	R:R:G94	2.11	No	No	0	9	8
222	R:R:G94	R:R:G95	2.11	No	No	0	8	5
223	R:R:G148	R:R:G149	2.11	No	No	0	4	3
224	R:R:G227	R:R:G228	2.11	No	No	0	4	5
225	R:R:G254	R:R:G255	2.11	No	No	0	6	5
226	R:R:G19	R:R:P21	2.03	No	No	0	8	5
227	R:R:G95	R:R:P194	2.03	No	No	0	5	9
228	R:R:P4	R:R:P5	1.95	No	No	0	6	7
229	R:R:A32	R:R:G29	1.95	No	No	0	3	7
230	R:R:A128	R:R:G125	1.95	No	No	0	4	1
231	R:R:A26	R:R:P273	1.87	No	Yes	0	9	9
232	R:R:A68	R:R:P73	1.87	No	No	0	3	4
233	R:R:A98	R:R:P194	1.87	No	No	0	7	9
234	R:R:G10	R:R:V13	1.84	No	No	0	5	6
235	R:R:G19	R:R:V270	1.84	No	No	0	8	6
236	R:R:G204	R:R:V203	1.84	No	No	0	4	3
237	R:R:G261	R:R:T264	1.82	No	No	0	6	5
238	R:R:A102	R:R:C201	1.81	No	No	0	6	7
239	R:R:A68	R:R:A71	1.79	No	No	0	3	4
240	R:R:A108	R:R:A208	1.79	No	No	0	8	5
241	R:R:P5	R:R:S69	1.78	No	No	0	7	4
242	R:R:P40	R:R:S123	1.78	No	Yes	0	7	8
243	R:R:P75	R:R:S77	1.78	No	No	0	8	1
244	R:R:P120	R:R:S123	1.78	No	Yes	0	4	8
245	R:R:P73	R:R:V64	1.77	No	No	0	4	4
246	R:R:G49	R:R:I27	1.76	No	No	0	8	7
247	R:R:P163	R:R:T162	1.75	No	No	0	4	2
248	R:R:A66	R:R:S8	1.71	No	No	0	6	3
249	R:R:G103	R:R:L106	1.71	No	No	0	8	7
250	R:R:G113	R:R:L112	1.71	No	No	0	4	6
251	R:R:G228	R:R:L231	1.71	No	No	0	5	5
252	R:R:G254	R:R:L253	1.71	No	Yes	0	6	3
253	R:R:G261	R:R:L260	1.71	No	No	0	6	3
254	R:R:G277	R:R:L279	1.71	No	No	0	4	5
255	R:R:A63	R:R:V13	1.7	No	No	0	7	6
256	R:R:A182	R:R:V141	1.7	No	No	0	4	5
257	R:R:D52	R:R:G49	1.68	Yes	No	0	9	8
258	R:R:L3	R:R:P4	1.64	No	No	0	7	6
259	R:R:S58	R:R:V57	1.62	No	No	0	7	4
260	R:R:S187	R:R:V245	1.62	No	No	0	5	5
261	R:R:D175	R:R:P176	1.61	Yes	No	0	6	1
262	R:R:C205	R:R:L209	1.59	No	No	0	7	8
263	R:R:A34	R:R:L38	1.58	No	No	4	5	5
264	R:R:A34	R:R:L42	1.58	No	Yes	4	5	7
265	R:R:A223	R:R:L206	1.58	No	No	0	5	5
266	R:R:A246	R:R:L253	1.58	No	Yes	0	5	3
267	R:R:M1	R:R:S256	1.53	No	No	0	6	1
268	R:R:F142	R:R:G143	1.51	Yes	No	0	4	3
269	R:R:L74	R:R:V64	1.49	No	No	0	7	4
270	R:R:A32	R:R:H33	1.46	No	No	0	3	4
271	R:R:F110	R:R:P111	1.44	Yes	No	0	6	9
272	R:R:P120	R:R:R119	1.44	No	No	0	4	5
273	R:R:I27	R:R:L46	1.43	No	No	0	7	6
274	R:R:G125	R:R:W124	1.41	No	No	0	1	4
275	R:R:C205	R:R:R104	1.39	No	No	0	7	9
276	R:R:P251	R:R:Y250	1.39	No	No	0	2	2
277	R:R:L25	R:R:L279	1.38	No	No	0	5	5
278	R:R:L133	R:R:L189	1.38	No	No	0	5	5
279	R:R:L133	R:R:L190	1.38	No	No	0	5	6
280	R:R:A208	R:R:R211	1.38	No	No	0	5	4
281	R:R:L235	R:R:L271	1.38	No	Yes	0	5	6
282	R:R:R35	R:R:T31	1.29	No	No	0	5	1
283	R:R:L25	R:R:R28	1.21	No	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.414	10	1	0
2	R:R:Y12	4.54167	6	0	9
3	R:R:N23	7.155	4	2	9
4	R:R:L42	4.464	5	4	7
5	R:R:Y44	5.5825	4	0	7
6	R:R:N47	8.718	5	3	9
7	R:R:D52	6.24	5	2	9
8	R:R:L55	5.955	4	0	7
9	R:R:K62	6.9075	4	1	7
10	R:R:W72	6.51	4	5	9
11	R:R:C79	7.26	4	5	9
12	R:R:H86	4.972	5	1	6
13	R:R:F87	8.56	4	1	6
14	R:R:F88	5.844	5	0	5
15	R:R:Y91	6.335	6	1	8
16	R:R:F96	6.925	4	3	6
17	R:R:Y105	4.64	5	6	7
18	R:R:F110	4.34	4	6	6
19	R:R:S123	4.27	4	0	8
20	R:R:F142	5.95	6	1	4
21	R:R:I160	5.208	5	5	2
22	R:R:N161	5.016	5	0	3
23	R:R:W174	6.46	5	1	4
24	R:R:D175	3.3975	4	0	6
25	R:R:R183	9.876	5	1	6
26	R:R:F191	8.82	5	1	9
27	R:R:Y202	5.115	4	0	8
28	R:R:Y240	6.70167	6	1	8
29	R:R:N241	8.6275	4	1	9
30	R:R:N244	5.264	5	1	7
31	R:R:L253	3.995	4	0	3
32	R:R:R258	6.735	4	1	7
33	R:R:V269	4.61167	6	2	7
34	R:R:L271	3.415	4	0	6
35	R:R:N272	7.666	5	2	9
36	R:R:P273	4.13	4	2	9
37	R:R:Y278	5.5975	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F87	21.5583	20.35	Yes	Yes	1	0	6
2	R:R:F87	R:R:H86	33.3356	3.39	Yes	Yes	1	6	6
3	R:R:H86	R:R:K62	32.3808	5.24	Yes	Yes	1	6	7
4	R:R:K62	R:R:Y12	28.7422	9.55	Yes	Yes	0	7	9
5	R:R:A66	R:R:Y12	19.3751	2.67	No	Yes	0	6	9
6	R:R:A66	R:R:S8	17.0517	1.71	No	No	0	6	3
7	R:R:L3	R:R:S8	14.6548	4.5	No	No	0	7	3
8	R:R:A63	R:R:Y12	12.2446	4	No	Yes	0	7	9
9	R:R:H86	R:R:L55	30.8319	3.86	Yes	Yes	0	6	7
10	R:R:L55	R:R:V269	60.2283	5.96	Yes	Yes	0	7	7
11	R:R:L59	R:R:V269	22.8001	4.47	No	Yes	0	9	7
12	R:R:L59	R:R:Y12	20.7905	3.52	No	Yes	0	9	9
13	R:R:D52	R:R:V269	45.1395	5.84	Yes	Yes	2	9	7
14	L:L:?1	R:R:L135	39.311	9.46	Yes	No	0	0	3
15	R:R:F88	R:R:L135	39.1908	4.87	Yes	No	0	5	3
16	R:R:F88	R:R:W131	100	5.01	Yes	No	0	5	9
17	R:R:N47	R:R:W131	98.9117	9.04	Yes	No	0	9	9
18	R:R:N47	R:R:V43	79.984	4.43	Yes	No	3	9	7
19	R:R:S123	R:R:V43	79.6835	9.7	Yes	No	0	8	7
20	R:R:P40	R:R:S123	44.3384	1.78	No	Yes	0	7	8
21	R:R:P40	R:R:T39	21.6451	3.5	No	No	0	7	7
22	R:R:L42	R:R:T39	14.8618	5.9	Yes	No	0	7	7
23	R:R:H33	R:R:L42	10.7491	3.86	No	Yes	0	4	7
24	R:R:P120	R:R:S123	24.2823	1.78	No	Yes	0	4	8
25	R:R:L38	R:R:P120	17.3855	3.28	No	No	0	5	4
26	R:R:L38	R:R:L42	14.0473	2.77	No	Yes	4	5	7
27	R:R:P40	R:R:Y114	23.5479	5.56	No	No	0	7	6
28	R:R:L42	R:R:Y278	14.3077	8.21	Yes	Yes	0	7	7
29	R:R:S123	R:R:Y44	15.0354	3.82	Yes	Yes	0	8	7
30	R:R:F96	R:R:N47	18.8877	12.08	Yes	Yes	3	6	9
31	R:R:D52	R:R:N272	36.8407	5.39	Yes	Yes	2	9	9
32	L:L:?1	R:R:N244	27.3134	3.13	Yes	Yes	1	0	7
33	R:R:N241	R:R:N244	38.7301	5.45	Yes	Yes	1	9	7
34	R:R:F191	R:R:N241	40.239	18.12	Yes	Yes	1	9	9
35	R:R:F191	R:R:V237	25.9781	5.24	Yes	No	1	9	8
36	R:R:S268	R:R:V237	26.392	3.23	No	No	0	9	8
37	R:R:N272	R:R:S268	10.7691	5.96	Yes	No	0	9	9
38	R:R:F88	R:R:P89	52.6305	5.78	Yes	No	0	5	8
39	R:R:F87	R:R:Y240	11.1363	5.16	Yes	Yes	1	6	8
40	R:R:N244	R:R:Y240	10.9227	5.81	Yes	Yes	1	7	8
41	R:R:E65	R:R:K62	13.3997	5.4	No	Yes	0	7	7
42	L:L:?1	R:R:F142	31.8133	13.87	Yes	Yes	1	0	4
43	R:R:F142	R:R:G159	29.6435	4.52	Yes	No	0	4	4
44	R:R:G159	R:R:I160	23.2474	3.53	No	Yes	0	4	2
45	R:R:I160	R:R:W72	15.0621	4.7	Yes	Yes	5	2	9
46	R:R:L74	R:R:W72	12.051	12.53	No	Yes	0	7	9
47	R:R:F88	R:R:V134	16.9248	5.24	Yes	No	0	5	7
48	R:R:L190	R:R:Y91	17.1585	4.69	No	Yes	0	6	8
49	R:R:F96	R:R:I130	15.2691	8.79	Yes	No	0	6	6
50	R:R:G95	R:R:I130	13.4063	3.53	No	No	0	5	6
51	R:R:N272	R:R:T232	25.1035	14.62	Yes	No	2	9	6
52	R:R:C236	R:R:S268	21.4314	5.16	No	No	0	8	9
53	R:R:C236	R:R:L271	17.2052	6.35	No	Yes	0	8	6
54	R:R:L271	R:R:V275	37.949	2.98	Yes	No	0	6	7
55	R:R:G228	R:R:V275	34.9179	5.52	No	No	0	5	7
56	R:R:G227	R:R:G228	31.8334	2.11	No	No	0	4	5
57	R:R:G227	R:R:Y202	30.2711	7.24	No	Yes	0	4	8
58	R:R:L106	R:R:Y114	20.1562	2.34	No	No	0	7	6
59	R:R:F110	R:R:L106	16.591	2.44	Yes	No	0	6	7
60	R:R:F110	R:R:Y105	11.103	5.16	Yes	Yes	6	6	7
61	L:L:?1	R:R:R183	17.7594	19.37	Yes	Yes	1	0	6
62	R:R:R183	R:R:W174	33.1152	4	Yes	Yes	1	6	4
63	R:R:D175	R:R:W174	21.1577	4.47	Yes	Yes	0	6	4
64	R:R:D175	R:R:S178	14.9486	4.42	Yes	No	0	6	1
65	R:R:E145	R:R:S178	12.8522	8.62	No	No	0	4	1
66	R:R:P147	R:R:W174	15.6696	12.16	No	Yes	0	3	4
67	R:R:N161	R:R:P147	14.1341	8.15	Yes	No	0	3	3
68	R:R:N241	R:R:S187	20.0895	7.45	Yes	No	0	9	5
69	R:R:S187	R:R:V245	17.6993	1.62	No	No	0	5	5
70	R:R:F184	R:R:V245	14.7817	3.93	No	No	0	4	5
71	R:R:F191	R:R:G238	13.4798	3.01	Yes	No	0	9	4
72	R:R:L206	R:R:Y202	22.246	5.86	No	Yes	0	5	8
73	R:R:K219	R:R:L206	19.088	5.64	No	No	0	6	5
74	R:R:K219	R:R:R218	15.7364	6.19	No	No	0	6	5
75	R:R:L214	R:R:R218	14.0406	3.64	No	No	0	3	5
76	R:R:G238	R:R:P239	10.8092	4.06	No	No	0	4	9
77	R:R:L55	R:R:P89	52.5905	9.85	Yes	No	0	7	8
78	R:R:Y240	R:R:Y91	10.2283	9.93	Yes	Yes	1	8	8
79	R:R:L190	R:R:V134	16.0168	8.94	No	No	0	6	7
80	R:R:N241	R:R:Y91	18.3402	3.49	Yes	Yes	1	9	8
81	R:R:L271	R:R:T232	23.835	2.95	Yes	No	0	6	6
82	R:R:N244	R:R:R183	14.7884	8.44	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A83	3.59	1	Yes	No	0	6	0	1
L:L:?1	R:R:V84	20.36	1	Yes	No	0	6	0	1
L:L:?1	R:R:F87	20.35	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L135	9.46	1	Yes	No	0	3	0	1
L:L:?1	R:R:L138	10.51	1	Yes	No	0	6	0	1
L:L:?1	R:R:G139	5.2	1	Yes	No	0	4	0	1
L:L:?1	R:R:F142	13.87	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R183	19.37	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N244	3.13	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R258	8.3	1	Yes	Yes	0	7	0	1
R:R:A83	R:R:F142	4.16	1	No	Yes	6	4	1	1
R:R:F87	R:R:H86	3.39	1	Yes	Yes	6	6	1	2
R:R:F87	R:R:Y240	5.16	1	Yes	Yes	6	8	1	2
R:R:F87	R:R:R258	5.34	1	Yes	Yes	6	7	1	1
R:R:F88	R:R:L135	4.87	0	Yes	No	5	3	2	1
R:R:L138	R:R:Y91	5.86	0	No	Yes	6	8	1	2
R:R:Y240	R:R:Y91	9.93	1	Yes	Yes	8	8	2	2
R:R:N241	R:R:Y91	3.49	1	Yes	Yes	9	8	2	2
R:R:N244	R:R:Y91	3.49	1	Yes	Yes	7	8	1	2
R:R:A146	R:R:F142	5.55	0	No	Yes	3	4	2	1
R:R:F142	R:R:G159	4.52	1	Yes	No	4	4	1	2
R:R:F142	R:R:L171	6.09	1	Yes	No	4	5	1	2
R:R:A146	R:R:W174	3.89	0	No	Yes	3	4	2	2
R:R:A179	R:R:W174	7.78	1	No	Yes	4	4	2	2
R:R:R183	R:R:W174	4	1	Yes	Yes	6	4	1	2
R:R:A179	R:R:R183	6.91	1	No	Yes	4	6	2	1
R:R:N244	R:R:R183	8.44	1	Yes	Yes	7	6	1	1
R:R:R183	R:R:R258	10.66	1	Yes	Yes	6	7	1	1
R:R:N244	R:R:Y240	5.81	1	Yes	Yes	7	8	1	2
R:R:N241	R:R:N244	5.45	1	Yes	Yes	9	7	2	1
R:R:R258	R:R:S243	2.64	1	Yes	No	7	5	1	2
R:R:F142	R:R:G143	1.51	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8T3V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	260
Number of Links	283
Number of Hubs	37
Number of Links mediated by Hubs	142
Number of Communities	6
Number of Nodes involved in Communities	40
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	37523
Length Of Smallest Path	3
Average Path Length	12.1636
Length of Longest Path	31
Minimum Path Strength	1.295
Average Path Strength	6.04283
Maximum Path Strength	20.355
Minimum Path Correlation	0.7
Average Path Correlation	0.924766
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	57.1325
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.1792
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • response to lipid • response to fatty acid • response to chemical • response to oxygen-containing compound • multicellular organismal process • interleukin-1 production • negative regulation of biological process • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cell communication • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HXA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HXA
Name	Doconexent
Synonyms	(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid
Identifier
Formula	C22 H32 O2
Molecular Weight	328.488
SMILES
PubChem	445580
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O14842
Sequence	>8T3V_nogp_Chain_R M D L P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R L T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S G A W P L P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F P L G Y Q A F R R P C Y S W G V C A A I W A L V L C H L G L V F G L E A P G G W L D H S N T S L G I N T P V N V C L E A W D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R S G L T H R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y P N L G G S W R K L G L I T G A W S V V L N P L V T G Y L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4PHU	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Fasiglifam	-	2.33	2014-07-16	doi.org/10.1038/nature13494
	5TZR	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666	-	2.2	2017-06-07	doi.org/10.1038/nsmb.3417
	5TZY	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666; AP8	-	3.22	2017-06-07	doi.org/10.1038/nsmb.3417
	5KW2	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	PubChem 133053953	-	2.76	2018-05-02	doi.org/10.1038/s41467-017-01240-w
	8EIT	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EIT (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8T3V	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3V (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384
	9K1C	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Doconexent	Gi1/β1/γ2	3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1C (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Doconexent		3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.