psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A83	3.59	Yes	No	1	0	6
2	L:L:?1	R:R:V84	20.36	Yes	No	0	0	6
3	L:L:?1	R:R:F87	20.35	Yes	Yes	1	0	6
4	L:L:?1	R:R:L135	9.46	Yes	No	0	0	3
5	L:L:?1	R:R:L138	10.51	Yes	No	0	0	6
6	L:L:?1	R:R:G139	5.2	Yes	No	0	0	4
7	L:L:?1	R:R:F142	13.87	Yes	Yes	1	0	4
8	L:L:?1	R:R:R183	19.37	Yes	Yes	1	0	6
9	L:L:?1	R:R:N244	3.13	Yes	Yes	1	0	7
10	L:L:?1	R:R:R258	8.3	Yes	Yes	1	0	7
11	R:R:L3	R:R:S8	4.5	No	No	0	7	3
12	R:R:K259	R:R:L3	4.23	No	No	0	3	7
13	R:R:L7	R:R:P4	9.85	No	No	0	7	6
14	R:R:F9	R:R:V13	3.93	No	No	0	6	6
15	R:R:F9	R:R:L67	7.31	No	No	0	6	4
16	R:R:I263	R:R:L11	4.28	No	No	0	6	5
17	R:R:L59	R:R:Y12	3.52	No	Yes	0	9	9
18	R:R:K62	R:R:Y12	9.55	Yes	Yes	0	7	9
19	R:R:A63	R:R:Y12	4	No	Yes	0	7	9
20	R:R:I263	R:R:Y12	4.84	No	Yes	0	6	9
21	R:R:A15	R:R:L59	4.73	No	No	0	7	9
22	R:R:F16	R:R:F20	6.43	No	No	0	6	5
23	R:R:F16	R:R:P60	15.89	No	No	0	6	9
24	R:R:L18	R:R:V270	5.96	No	No	0	6	6
25	R:R:G19	R:R:V269	3.68	No	Yes	0	8	7
26	R:R:F20	R:R:T56	5.19	No	No	0	5	6
27	R:R:L22	R:R:P273	4.93	No	Yes	0	7	9
28	R:R:D52	R:R:N23	13.46	Yes	Yes	2	9	9
29	R:R:N23	R:R:T56	7.31	Yes	No	2	9	6
30	R:R:N23	R:R:V269	2.96	Yes	Yes	2	9	7
31	R:R:N23	R:R:P273	4.89	Yes	Yes	2	9	9
32	R:R:I27	R:R:L53	4.28	No	No	0	7	7
33	R:R:A30	R:R:L46	3.15	No	No	0	6	6
34	R:R:H33	R:R:L42	3.86	No	Yes	0	4	7
35	R:R:R37	R:R:T39	6.47	No	No	0	4	7
36	R:R:R118	R:R:R37	8.53	No	No	0	8	4
37	R:R:L38	R:R:P120	3.28	No	No	0	5	4
38	R:R:P40	R:R:T39	3.5	No	No	0	7	7
39	R:R:L42	R:R:T39	5.9	Yes	No	0	7	7
40	R:R:P40	R:R:Y114	5.56	No	No	0	7	6
41	R:R:S41	R:R:Y278	5.09	No	Yes	0	7	7
42	R:R:L42	R:R:Y278	8.21	Yes	Yes	0	7	7
43	R:R:N47	R:R:V43	4.43	Yes	No	3	9	7
44	R:R:S123	R:R:V43	9.7	Yes	No	0	8	7
45	R:R:V43	R:R:W124	13.48	No	No	3	7	4
46	R:R:A99	R:R:Y44	5.34	No	Yes	0	6	7
47	R:R:L100	R:R:Y44	9.38	No	Yes	0	8	7
48	R:R:S123	R:R:Y44	3.82	Yes	Yes	0	8	7
49	R:R:V126	R:R:Y44	3.79	No	Yes	0	5	7
50	R:R:A45	R:R:Y278	5.34	No	Yes	0	7	7
51	R:R:F96	R:R:N47	12.08	Yes	Yes	3	6	9
52	R:R:N47	R:R:W124	10.17	Yes	No	3	9	4
53	R:R:C127	R:R:N47	7.87	No	Yes	3	7	9
54	R:R:N47	R:R:W131	9.04	Yes	No	0	9	9
55	R:R:L48	R:R:N272	8.24	No	Yes	0	9	9
56	R:R:D52	R:R:V269	5.84	Yes	Yes	2	9	7
57	R:R:D52	R:R:N272	5.39	Yes	Yes	2	9	9
58	R:R:D52	R:R:P273	4.83	Yes	Yes	2	9	9
59	R:R:L54	R:R:P89	3.28	No	No	0	7	8
60	R:R:H86	R:R:L55	3.86	Yes	Yes	0	6	7
61	R:R:L55	R:R:P89	9.85	Yes	No	0	7	8
62	R:R:L55	R:R:L90	4.15	Yes	No	0	7	7
63	R:R:L55	R:R:V269	5.96	Yes	Yes	0	7	7
64	R:R:T56	R:R:V269	4.76	No	Yes	2	6	7
65	R:R:A85	R:R:S58	3.42	No	No	0	5	7
66	R:R:H86	R:R:S58	5.58	Yes	No	0	6	7
67	R:R:L59	R:R:V269	4.47	No	Yes	0	9	7
68	R:R:F82	R:R:L61	6.09	No	No	0	5	6
69	R:R:E65	R:R:K62	5.4	No	Yes	0	7	7
70	R:R:F82	R:R:K62	7.44	No	Yes	1	5	7
71	R:R:H86	R:R:K62	5.24	Yes	Yes	1	6	7
72	R:R:E65	R:R:G70	3.27	No	No	0	7	6
73	R:R:E172	R:R:E65	6.34	No	No	0	6	7
74	R:R:L74	R:R:W72	12.53	No	Yes	0	7	9
75	R:R:C79	R:R:W72	6.53	Yes	Yes	5	9	9
76	R:R:I160	R:R:W72	4.7	Yes	Yes	5	2	9
77	R:R:L74	R:R:P75	3.28	No	No	0	7	8
78	R:R:A76	R:R:I160	3.25	No	Yes	0	3	2
79	R:R:C79	R:R:P80	3.77	Yes	No	0	9	7
80	R:R:C79	R:R:I160	11.46	Yes	Yes	5	9	2
81	R:R:C170	R:R:C79	7.28	No	Yes	0	9	9
82	R:R:G159	R:R:P80	4.06	No	No	0	4	7
83	R:R:F82	R:R:H86	6.79	No	Yes	1	5	6
84	R:R:A83	R:R:F142	4.16	No	Yes	1	6	4
85	R:R:F87	R:R:H86	3.39	Yes	Yes	1	6	6
86	R:R:F87	R:R:Y240	5.16	Yes	Yes	1	6	8
87	R:R:F87	R:R:R258	5.34	Yes	Yes	1	6	7
88	R:R:F88	R:R:P89	5.78	Yes	No	0	5	8
89	R:R:A92	R:R:F88	8.32	No	Yes	0	6	5
90	R:R:F88	R:R:W131	5.01	Yes	No	0	5	9
91	R:R:F88	R:R:V134	5.24	Yes	No	0	5	7
92	R:R:F88	R:R:L135	4.87	Yes	No	0	5	3
93	R:R:L90	R:R:Y240	11.72	No	Yes	0	7	8
94	R:R:L138	R:R:Y91	5.86	No	Yes	0	6	8
95	R:R:L186	R:R:Y91	10.55	No	Yes	0	6	8
96	R:R:L190	R:R:Y91	4.69	No	Yes	0	6	8
97	R:R:Y240	R:R:Y91	9.93	Yes	Yes	1	8	8
98	R:R:N241	R:R:Y91	3.49	Yes	Yes	1	9	8
99	R:R:N244	R:R:Y91	3.49	Yes	Yes	1	7	8
100	R:R:G95	R:R:I130	3.53	No	No	0	5	6
101	R:R:C127	R:R:F96	4.19	No	Yes	3	7	6
102	R:R:F96	R:R:I130	8.79	Yes	No	0	6	6
103	R:R:A229	R:R:L97	3.15	No	No	0	8	8
104	R:R:L97	R:R:T232	2.95	No	No	2	8	6
105	R:R:L97	R:R:N272	4.12	No	Yes	2	8	9
106	R:R:A98	R:R:I197	3.25	No	No	0	7	6
107	R:R:L100	R:R:R104	9.72	No	No	0	8	9
108	R:R:S101	R:R:T198	3.2	No	No	0	9	8
109	R:R:A109	R:R:Y105	6.67	No	Yes	6	8	7
110	R:R:F110	R:R:Y105	5.16	Yes	Yes	6	6	7
111	R:R:F200	R:R:Y105	3.09	No	Yes	0	4	7
112	R:R:C201	R:R:Y105	5.38	No	Yes	0	7	7
113	R:R:G107	R:R:Y114	7.24	No	No	0	8	6
114	R:R:A109	R:R:F110	8.32	No	Yes	6	8	6
115	R:R:Q115	R:R:R118	15.19	No	No	0	5	8
116	R:R:A116	R:R:F117	8.32	No	No	0	3	4
117	R:R:C121	R:R:R119	6.96	No	No	0	4	5
118	R:R:R119	R:R:Y122	6.17	No	No	0	5	3
119	R:R:L190	R:R:V134	8.94	No	No	0	6	7
120	R:R:C136	R:R:L140	3.17	No	No	0	4	7
121	R:R:H137	R:R:S185	8.37	No	No	0	5	5
122	R:R:H137	R:R:L186	9	No	No	0	5	6
123	R:R:H137	R:R:L189	3.86	No	No	0	5	5
124	R:R:A146	R:R:F142	5.55	No	Yes	0	3	4
125	R:R:F142	R:R:G159	4.52	Yes	No	0	4	4
126	R:R:F142	R:R:L171	6.09	Yes	No	0	4	5
127	R:R:L144	R:R:W150	3.42	No	No	0	3	4
128	R:R:E145	R:R:L151	7.95	No	No	0	4	5
129	R:R:E145	R:R:S178	8.62	No	No	0	4	1
130	R:R:A182	R:R:E145	3.02	No	No	0	4	4
131	R:R:A146	R:R:W174	3.89	No	Yes	0	3	4
132	R:R:N161	R:R:P147	8.15	Yes	No	0	3	3
133	R:R:P147	R:R:W174	12.16	No	Yes	0	3	4
134	R:R:D152	R:R:G148	5.03	No	No	0	4	4
135	R:R:L151	R:R:W150	3.42	No	No	0	5	4
136	R:R:D152	R:R:S154	4.42	No	No	0	4	6
137	R:R:S154	R:R:T156	9.59	No	No	0	6	1
138	R:R:N161	R:R:T156	2.92	Yes	No	0	3	1
139	R:R:I160	R:R:S157	3.1	Yes	No	0	2	2
140	R:R:G159	R:R:I160	3.53	No	Yes	0	4	2
141	R:R:N161	R:R:P163	4.89	Yes	No	0	3	4
142	R:R:N161	R:R:V169	4.43	Yes	No	0	3	5
143	R:R:A173	R:R:N161	4.69	No	Yes	0	5	3
144	R:R:N165	R:R:T162	5.85	No	No	0	4	2
145	R:R:E172	R:R:V169	5.7	No	No	0	6	5
146	R:R:D175	R:R:W174	4.47	Yes	Yes	0	6	4
147	R:R:A179	R:R:W174	7.78	No	Yes	1	4	4
148	R:R:R183	R:R:W174	4	Yes	Yes	1	6	4
149	R:R:A177	R:R:D175	3.09	No	Yes	0	1	6
150	R:R:D175	R:R:S178	4.42	Yes	No	0	6	1
151	R:R:A179	R:R:R183	6.91	No	Yes	1	4	6
152	R:R:G180	R:R:P181	4.06	No	No	0	3	4
153	R:R:F248	R:R:P181	8.67	No	No	0	5	4
154	R:R:N244	R:R:R183	8.44	Yes	Yes	1	7	6
155	R:R:R183	R:R:R258	10.66	Yes	Yes	1	6	7
156	R:R:F184	R:R:L188	3.65	No	No	0	4	4
157	R:R:F184	R:R:V245	3.93	No	No	0	4	5
158	R:R:F184	R:R:F248	12.86	No	No	0	4	5
159	R:R:F192	R:R:S187	6.61	No	No	0	4	5
160	R:R:N241	R:R:S187	7.45	Yes	No	0	9	5
161	R:R:F191	R:R:F192	12.86	Yes	No	0	9	4
162	R:R:F191	R:R:L233	4.87	Yes	No	1	9	9
163	R:R:F191	R:R:V237	5.24	Yes	No	1	9	8
164	R:R:F191	R:R:G238	3.01	Yes	No	0	9	4
165	R:R:F191	R:R:N241	18.12	Yes	Yes	1	9	9
166	R:R:L193	R:R:P194	6.57	No	No	0	4	9
167	R:R:L195	R:R:L233	5.54	No	No	0	6	9
168	R:R:L195	R:R:L234	5.54	No	No	0	6	5
169	R:R:L230	R:R:T198	4.42	No	No	0	8	8
170	R:R:L206	R:R:Y202	5.86	No	Yes	0	5	8
171	R:R:G227	R:R:Y202	7.24	No	Yes	0	4	8
172	R:R:L230	R:R:Y202	4.69	No	Yes	0	8	8
173	R:R:K219	R:R:L206	5.64	No	No	0	6	5
174	R:R:R207	R:R:R211	5.33	No	No	0	4	4
175	R:R:A222	R:R:L209	4.73	No	No	0	8	8
176	R:R:A210	R:R:K219	4.82	No	No	0	2	6
177	R:R:G213	R:R:S212	3.71	No	No	0	4	5
178	R:R:L214	R:R:S212	3	No	No	0	3	5
179	R:R:L214	R:R:R217	10.93	No	No	0	3	3
180	R:R:L214	R:R:R218	3.64	No	No	0	3	5
181	R:R:R217	R:R:T215	15.52	No	No	0	3	3
182	R:R:H216	R:R:L220	3.86	No	No	0	2	4
183	R:R:K219	R:R:R218	6.19	No	No	0	6	5
184	R:R:R221	R:R:V225	5.23	No	No	0	7	7
185	R:R:V225	R:R:W224	3.68	No	No	0	7	5
186	R:R:G228	R:R:V275	5.52	No	No	0	5	7
187	R:R:L271	R:R:T232	2.95	Yes	No	0	6	6
188	R:R:N272	R:R:T232	14.62	Yes	No	2	9	6
189	R:R:L233	R:R:V237	2.98	No	No	1	9	8
190	R:R:C236	R:R:S268	5.16	No	No	0	8	9
191	R:R:C236	R:R:L271	6.35	No	Yes	0	8	6
192	R:R:S268	R:R:V237	3.23	No	No	0	9	8
193	R:R:G238	R:R:P239	4.06	No	No	0	4	9
194	R:R:P239	R:R:T264	10.49	No	No	0	9	5
195	R:R:N244	R:R:Y240	5.81	Yes	Yes	1	7	8
196	R:R:L262	R:R:Y240	4.69	No	Yes	0	5	8
197	R:R:N241	R:R:N244	5.45	Yes	Yes	1	9	7
198	R:R:L249	R:R:Y250	8.21	No	No	0	4	2
199	R:R:L253	R:R:Y250	5.86	Yes	No	0	3	2
200	R:R:N252	R:R:P251	3.26	No	No	0	1	2
201	R:R:L253	R:R:W257	6.83	Yes	No	0	3	5
202	R:R:N272	R:R:S268	5.96	Yes	No	0	9	9
203	R:R:L271	R:R:V275	2.98	Yes	No	0	6	7
204	R:R:L274	R:R:V275	2.98	No	No	0	6	7
205	R:R:T276	R:R:Y278	3.75	No	Yes	0	7	7
206	R:R:G204	R:R:Y105	2.9	No	Yes	0	4	7
207	R:R:G265	R:R:Y240	2.9	No	Yes	0	8	8
208	R:R:L38	R:R:L42	2.77	No	Yes	4	5	7
209	R:R:A66	R:R:Y12	2.67	No	Yes	0	6	9
210	R:R:A266	R:R:Y12	2.67	No	Yes	0	6	9
211	R:R:A226	R:R:Y202	2.67	No	Yes	0	7	8
212	R:R:F96	R:R:S51	2.64	Yes	No	0	6	8
213	R:R:R258	R:R:S243	2.64	Yes	No	0	7	5
214	R:R:C236	R:R:W267	2.61	No	No	0	8	4
215	R:R:A14	R:R:W267	2.59	No	No	0	4	4
216	R:R:F110	R:R:L106	2.44	Yes	No	0	6	7
217	R:R:L106	R:R:Y114	2.34	No	No	0	7	6
218	R:R:M1	R:R:W257	2.33	No	No	0	6	5
219	R:R:L78	R:R:W72	2.28	No	Yes	0	5	9
220	R:R:R217	R:R:R221	2.13	No	No	0	3	7
221	R:R:G93	R:R:G94	2.11	No	No	0	9	8
222	R:R:G94	R:R:G95	2.11	No	No	0	8	5
223	R:R:G148	R:R:G149	2.11	No	No	0	4	3
224	R:R:G227	R:R:G228	2.11	No	No	0	4	5
225	R:R:G254	R:R:G255	2.11	No	No	0	6	5
226	R:R:G19	R:R:P21	2.03	No	No	0	8	5
227	R:R:G95	R:R:P194	2.03	No	No	0	5	9
228	R:R:P4	R:R:P5	1.95	No	No	0	6	7
229	R:R:A32	R:R:G29	1.95	No	No	0	3	7
230	R:R:A128	R:R:G125	1.95	No	No	0	4	1
231	R:R:A26	R:R:P273	1.87	No	Yes	0	9	9
232	R:R:A68	R:R:P73	1.87	No	No	0	3	4
233	R:R:A98	R:R:P194	1.87	No	No	0	7	9
234	R:R:G10	R:R:V13	1.84	No	No	0	5	6
235	R:R:G19	R:R:V270	1.84	No	No	0	8	6
236	R:R:G204	R:R:V203	1.84	No	No	0	4	3
237	R:R:G261	R:R:T264	1.82	No	No	0	6	5
238	R:R:A102	R:R:C201	1.81	No	No	0	6	7
239	R:R:A68	R:R:A71	1.79	No	No	0	3	4
240	R:R:A108	R:R:A208	1.79	No	No	0	8	5
241	R:R:P5	R:R:S69	1.78	No	No	0	7	4
242	R:R:P40	R:R:S123	1.78	No	Yes	0	7	8
243	R:R:P75	R:R:S77	1.78	No	No	0	8	1
244	R:R:P120	R:R:S123	1.78	No	Yes	0	4	8
245	R:R:P73	R:R:V64	1.77	No	No	0	4	4
246	R:R:G49	R:R:I27	1.76	No	No	0	8	7
247	R:R:P163	R:R:T162	1.75	No	No	0	4	2
248	R:R:A66	R:R:S8	1.71	No	No	0	6	3
249	R:R:G103	R:R:L106	1.71	No	No	0	8	7
250	R:R:G113	R:R:L112	1.71	No	No	0	4	6
251	R:R:G228	R:R:L231	1.71	No	No	0	5	5
252	R:R:G254	R:R:L253	1.71	No	Yes	0	6	3
253	R:R:G261	R:R:L260	1.71	No	No	0	6	3
254	R:R:G277	R:R:L279	1.71	No	No	0	4	5
255	R:R:A63	R:R:V13	1.7	No	No	0	7	6
256	R:R:A182	R:R:V141	1.7	No	No	0	4	5
257	R:R:D52	R:R:G49	1.68	Yes	No	0	9	8
258	R:R:L3	R:R:P4	1.64	No	No	0	7	6
259	R:R:S58	R:R:V57	1.62	No	No	0	7	4
260	R:R:S187	R:R:V245	1.62	No	No	0	5	5
261	R:R:D175	R:R:P176	1.61	Yes	No	0	6	1
262	R:R:C205	R:R:L209	1.59	No	No	0	7	8
263	R:R:A34	R:R:L38	1.58	No	No	4	5	5
264	R:R:A34	R:R:L42	1.58	No	Yes	4	5	7
265	R:R:A223	R:R:L206	1.58	No	No	0	5	5
266	R:R:A246	R:R:L253	1.58	No	Yes	0	5	3
267	R:R:M1	R:R:S256	1.53	No	No	0	6	1
268	R:R:F142	R:R:G143	1.51	Yes	No	0	4	3
269	R:R:L74	R:R:V64	1.49	No	No	0	7	4
270	R:R:A32	R:R:H33	1.46	No	No	0	3	4
271	R:R:F110	R:R:P111	1.44	Yes	No	0	6	9
272	R:R:P120	R:R:R119	1.44	No	No	0	4	5
273	R:R:I27	R:R:L46	1.43	No	No	0	7	6
274	R:R:G125	R:R:W124	1.41	No	No	0	1	4
275	R:R:C205	R:R:R104	1.39	No	No	0	7	9
276	R:R:P251	R:R:Y250	1.39	No	No	0	2	2
277	R:R:L25	R:R:L279	1.38	No	No	0	5	5
278	R:R:L133	R:R:L189	1.38	No	No	0	5	5
279	R:R:L133	R:R:L190	1.38	No	No	0	5	6
280	R:R:A208	R:R:R211	1.38	No	No	0	5	4
281	R:R:L235	R:R:L271	1.38	No	Yes	0	5	6
282	R:R:R35	R:R:T31	1.29	No	No	0	5	1
283	R:R:L25	R:R:R28	1.21	No	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.414	10	1	0
2	R:R:Y12	4.54167	6	0	9
3	R:R:N23	7.155	4	2	9
4	R:R:L42	4.464	5	4	7
5	R:R:Y44	5.5825	4	0	7
6	R:R:N47	8.718	5	3	9
7	R:R:D52	6.24	5	2	9
8	R:R:L55	5.955	4	0	7
9	R:R:K62	6.9075	4	1	7
10	R:R:W72	6.51	4	5	9
11	R:R:C79	7.26	4	5	9
12	R:R:H86	4.972	5	1	6
13	R:R:F87	8.56	4	1	6
14	R:R:F88	5.844	5	0	5
15	R:R:Y91	6.335	6	1	8
16	R:R:F96	6.925	4	3	6
17	R:R:Y105	4.64	5	6	7
18	R:R:F110	4.34	4	6	6
19	R:R:S123	4.27	4	0	8
20	R:R:F142	5.95	6	1	4
21	R:R:I160	5.208	5	5	2
22	R:R:N161	5.016	5	0	3
23	R:R:W174	6.46	5	1	4
24	R:R:D175	3.3975	4	0	6
25	R:R:R183	9.876	5	1	6
26	R:R:F191	8.82	5	1	9
27	R:R:Y202	5.115	4	0	8
28	R:R:Y240	6.70167	6	1	8
29	R:R:N241	8.6275	4	1	9
30	R:R:N244	5.264	5	1	7
31	R:R:L253	3.995	4	0	3
32	R:R:R258	6.735	4	1	7
33	R:R:V269	4.61167	6	2	7
34	R:R:L271	3.415	4	0	6
35	R:R:N272	7.666	5	2	9
36	R:R:P273	4.13	4	2	9
37	R:R:Y278	5.5975	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F87	21.5583	20.35	Yes	Yes	1	0	6
2	R:R:F87	R:R:H86	33.3356	3.39	Yes	Yes	1	6	6
3	R:R:H86	R:R:K62	32.3808	5.24	Yes	Yes	1	6	7
4	R:R:K62	R:R:Y12	28.7422	9.55	Yes	Yes	0	7	9
5	R:R:A66	R:R:Y12	19.3751	2.67	No	Yes	0	6	9
6	R:R:A66	R:R:S8	17.0517	1.71	No	No	0	6	3
7	R:R:L3	R:R:S8	14.6548	4.5	No	No	0	7	3
8	R:R:A63	R:R:Y12	12.2446	4	No	Yes	0	7	9
9	R:R:H86	R:R:L55	30.8319	3.86	Yes	Yes	0	6	7
10	R:R:L55	R:R:V269	60.2283	5.96	Yes	Yes	0	7	7
11	R:R:L59	R:R:V269	22.8001	4.47	No	Yes	0	9	7
12	R:R:L59	R:R:Y12	20.7905	3.52	No	Yes	0	9	9
13	R:R:D52	R:R:V269	45.1395	5.84	Yes	Yes	2	9	7
14	L:L:?1	R:R:L135	39.311	9.46	Yes	No	0	0	3
15	R:R:F88	R:R:L135	39.1908	4.87	Yes	No	0	5	3
16	R:R:F88	R:R:W131	100	5.01	Yes	No	0	5	9
17	R:R:N47	R:R:W131	98.9117	9.04	Yes	No	0	9	9
18	R:R:N47	R:R:V43	79.984	4.43	Yes	No	3	9	7
19	R:R:S123	R:R:V43	79.6835	9.7	Yes	No	0	8	7
20	R:R:P40	R:R:S123	44.3384	1.78	No	Yes	0	7	8
21	R:R:P40	R:R:T39	21.6451	3.5	No	No	0	7	7
22	R:R:L42	R:R:T39	14.8618	5.9	Yes	No	0	7	7
23	R:R:H33	R:R:L42	10.7491	3.86	No	Yes	0	4	7
24	R:R:P120	R:R:S123	24.2823	1.78	No	Yes	0	4	8
25	R:R:L38	R:R:P120	17.3855	3.28	No	No	0	5	4
26	R:R:L38	R:R:L42	14.0473	2.77	No	Yes	4	5	7
27	R:R:P40	R:R:Y114	23.5479	5.56	No	No	0	7	6
28	R:R:L42	R:R:Y278	14.3077	8.21	Yes	Yes	0	7	7
29	R:R:S123	R:R:Y44	15.0354	3.82	Yes	Yes	0	8	7
30	R:R:F96	R:R:N47	18.8877	12.08	Yes	Yes	3	6	9
31	R:R:D52	R:R:N272	36.8407	5.39	Yes	Yes	2	9	9
32	L:L:?1	R:R:N244	27.3134	3.13	Yes	Yes	1	0	7
33	R:R:N241	R:R:N244	38.7301	5.45	Yes	Yes	1	9	7
34	R:R:F191	R:R:N241	40.239	18.12	Yes	Yes	1	9	9
35	R:R:F191	R:R:V237	25.9781	5.24	Yes	No	1	9	8
36	R:R:S268	R:R:V237	26.392	3.23	No	No	0	9	8
37	R:R:N272	R:R:S268	10.7691	5.96	Yes	No	0	9	9
38	R:R:F88	R:R:P89	52.6305	5.78	Yes	No	0	5	8
39	R:R:F87	R:R:Y240	11.1363	5.16	Yes	Yes	1	6	8
40	R:R:N244	R:R:Y240	10.9227	5.81	Yes	Yes	1	7	8
41	R:R:E65	R:R:K62	13.3997	5.4	No	Yes	0	7	7
42	L:L:?1	R:R:F142	31.8133	13.87	Yes	Yes	1	0	4
43	R:R:F142	R:R:G159	29.6435	4.52	Yes	No	0	4	4
44	R:R:G159	R:R:I160	23.2474	3.53	No	Yes	0	4	2
45	R:R:I160	R:R:W72	15.0621	4.7	Yes	Yes	5	2	9
46	R:R:L74	R:R:W72	12.051	12.53	No	Yes	0	7	9
47	R:R:F88	R:R:V134	16.9248	5.24	Yes	No	0	5	7
48	R:R:L190	R:R:Y91	17.1585	4.69	No	Yes	0	6	8
49	R:R:F96	R:R:I130	15.2691	8.79	Yes	No	0	6	6
50	R:R:G95	R:R:I130	13.4063	3.53	No	No	0	5	6
51	R:R:N272	R:R:T232	25.1035	14.62	Yes	No	2	9	6
52	R:R:C236	R:R:S268	21.4314	5.16	No	No	0	8	9
53	R:R:C236	R:R:L271	17.2052	6.35	No	Yes	0	8	6
54	R:R:L271	R:R:V275	37.949	2.98	Yes	No	0	6	7
55	R:R:G228	R:R:V275	34.9179	5.52	No	No	0	5	7
56	R:R:G227	R:R:G228	31.8334	2.11	No	No	0	4	5
57	R:R:G227	R:R:Y202	30.2711	7.24	No	Yes	0	4	8
58	R:R:L106	R:R:Y114	20.1562	2.34	No	No	0	7	6
59	R:R:F110	R:R:L106	16.591	2.44	Yes	No	0	6	7
60	R:R:F110	R:R:Y105	11.103	5.16	Yes	Yes	6	6	7
61	L:L:?1	R:R:R183	17.7594	19.37	Yes	Yes	1	0	6
62	R:R:R183	R:R:W174	33.1152	4	Yes	Yes	1	6	4
63	R:R:D175	R:R:W174	21.1577	4.47	Yes	Yes	0	6	4
64	R:R:D175	R:R:S178	14.9486	4.42	Yes	No	0	6	1
65	R:R:E145	R:R:S178	12.8522	8.62	No	No	0	4	1
66	R:R:P147	R:R:W174	15.6696	12.16	No	Yes	0	3	4
67	R:R:N161	R:R:P147	14.1341	8.15	Yes	No	0	3	3
68	R:R:N241	R:R:S187	20.0895	7.45	Yes	No	0	9	5
69	R:R:S187	R:R:V245	17.6993	1.62	No	No	0	5	5
70	R:R:F184	R:R:V245	14.7817	3.93	No	No	0	4	5
71	R:R:F191	R:R:G238	13.4798	3.01	Yes	No	0	9	4
72	R:R:L206	R:R:Y202	22.246	5.86	No	Yes	0	5	8
73	R:R:K219	R:R:L206	19.088	5.64	No	No	0	6	5
74	R:R:K219	R:R:R218	15.7364	6.19	No	No	0	6	5
75	R:R:L214	R:R:R218	14.0406	3.64	No	No	0	3	5
76	R:R:G238	R:R:P239	10.8092	4.06	No	No	0	4	9
77	R:R:L55	R:R:P89	52.5905	9.85	Yes	No	0	7	8
78	R:R:Y240	R:R:Y91	10.2283	9.93	Yes	Yes	1	8	8
79	R:R:L190	R:R:V134	16.0168	8.94	No	No	0	6	7
80	R:R:N241	R:R:Y91	18.3402	3.49	Yes	Yes	1	9	8
81	R:R:L271	R:R:T232	23.835	2.95	Yes	No	0	6	6
82	R:R:N244	R:R:R183	14.7884	8.44	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A83	3.59	1	Yes	No	0	6	0	1
L:L:?1	R:R:V84	20.36	1	Yes	No	0	6	0	1
L:L:?1	R:R:F87	20.35	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L135	9.46	1	Yes	No	0	3	0	1
L:L:?1	R:R:L138	10.51	1	Yes	No	0	6	0	1
L:L:?1	R:R:G139	5.2	1	Yes	No	0	4	0	1
L:L:?1	R:R:F142	13.87	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R183	19.37	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N244	3.13	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R258	8.3	1	Yes	Yes	0	7	0	1
R:R:A83	R:R:F142	4.16	1	No	Yes	6	4	1	1
R:R:F87	R:R:H86	3.39	1	Yes	Yes	6	6	1	2
R:R:F87	R:R:Y240	5.16	1	Yes	Yes	6	8	1	2
R:R:F87	R:R:R258	5.34	1	Yes	Yes	6	7	1	1
R:R:F88	R:R:L135	4.87	0	Yes	No	5	3	2	1
R:R:L138	R:R:Y91	5.86	0	No	Yes	6	8	1	2
R:R:Y240	R:R:Y91	9.93	1	Yes	Yes	8	8	2	2
R:R:N241	R:R:Y91	3.49	1	Yes	Yes	9	8	2	2
R:R:N244	R:R:Y91	3.49	1	Yes	Yes	7	8	1	2
R:R:A146	R:R:F142	5.55	0	No	Yes	3	4	2	1
R:R:F142	R:R:G159	4.52	1	Yes	No	4	4	1	2
R:R:F142	R:R:L171	6.09	1	Yes	No	4	5	1	2
R:R:A146	R:R:W174	3.89	0	No	Yes	3	4	2	2
R:R:A179	R:R:W174	7.78	1	No	Yes	4	4	2	2
R:R:R183	R:R:W174	4	1	Yes	Yes	6	4	1	2
R:R:A179	R:R:R183	6.91	1	No	Yes	4	6	2	1
R:R:N244	R:R:R183	8.44	1	Yes	Yes	7	6	1	1
R:R:R183	R:R:R258	10.66	1	Yes	Yes	6	7	1	1
R:R:N244	R:R:Y240	5.81	1	Yes	Yes	7	8	1	2
R:R:N241	R:R:N244	5.45	1	Yes	Yes	9	7	2	1
R:R:R258	R:R:S243	2.64	1	Yes	No	7	5	1	2
R:R:F142	R:R:G143	1.51	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8T3V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	260
Number of Links	283
Number of Hubs	37
Number of Links mediated by Hubs	142
Number of Communities	6
Number of Nodes involved in Communities	40
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	37523
Length Of Smallest Path	3
Average Path Length	12.1636
Length of Longest Path	31
Minimum Path Strength	1.295
Average Path Strength	6.04283
Maximum Path Strength	20.355
Minimum Path Correlation	0.7
Average Path Correlation	0.924766
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	57.1325
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.1792
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HXA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HXA
Name	Doconexent
Synonyms	4,7,10,13,16,19-docosahexaenoic acid
Identifier
Formula	C22 H32 O2
Molecular Weight	328.488
SMILES
PubChem	445580
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O14842
Sequence	>8T3V_nogp_Chain_R M D L P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R L T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S G A W P L P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F P L G Y Q A F R R P C Y S W G V C A A I W A L V L C H L G L V F G L E A P G G W L D H S N T S L G I N T P V N V C L E A W D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R S G L T H R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y P N L G G S W R K L G L I T G A W S V V L N P L V T G Y L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5KW2	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	PubChem 133053953	-	2.76	2018-05-02	doi.org/10.1038/s41467-017-01240-w
	5TZY	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666; AP8	-	3.22	2017-06-07	doi.org/10.1038/nsmb.3417
	5TZR	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666	-	2.2	2017-06-07	doi.org/10.1038/nsmb.3417
	4PHU	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Fasiglifam	-	2.33	2014-07-16	doi.org/10.1038/nature13494
	9K1C	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA	Gi1/β1/γ2	3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1C (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA		3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8EIT	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EIT (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8T3V	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3V (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384

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