psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F87	12.02	Yes	No	1	0	6
2	L:L:?1	R:R:Y91	8.9	Yes	No	1	0	8
3	L:L:?1	R:R:F142	6.47	Yes	Yes	0	0	4
4	L:L:?1	R:R:R183	11.07	Yes	Yes	1	0	6
5	L:L:?1	R:R:L186	3.15	Yes	No	0	0	6
6	L:L:?1	R:R:Y240	4.45	Yes	Yes	1	0	8
7	L:L:?1	R:R:R258	5.54	Yes	Yes	1	0	7
8	R:R:L3	R:R:P4	3.28	Yes	No	0	7	6
9	R:R:L3	R:R:S256	3	Yes	No	0	7	1
10	R:R:L7	R:R:P4	6.57	No	No	0	7	6
11	R:R:L11	R:R:L7	2.77	No	No	0	5	7
12	R:R:F9	R:R:V13	3.93	Yes	No	0	6	6
13	R:R:A63	R:R:F9	2.77	No	Yes	0	7	6
14	R:R:F9	R:R:L67	9.74	Yes	No	0	6	4
15	R:R:I263	R:R:L11	5.71	No	No	0	6	5
16	R:R:L59	R:R:Y12	3.52	No	Yes	0	9	9
17	R:R:A63	R:R:Y12	4	No	Yes	0	7	9
18	R:R:L262	R:R:Y12	4.69	No	Yes	0	5	9
19	R:R:I263	R:R:Y12	4.84	No	Yes	0	6	9
20	R:R:F16	R:R:P60	8.67	No	No	0	6	9
21	R:R:F20	R:R:P21	4.33	No	No	0	5	5
22	R:R:F20	R:R:V24	5.24	No	No	0	5	3
23	R:R:L22	R:R:P273	4.93	No	No	0	7	9
24	R:R:L22	R:R:L279	2.77	No	No	0	7	5
25	R:R:D52	R:R:N23	12.12	Yes	Yes	1	9	9
26	R:R:L53	R:R:N23	2.75	No	Yes	0	7	9
27	R:R:N23	R:R:T56	5.85	Yes	Yes	1	9	6
28	R:R:N23	R:R:P273	9.77	Yes	No	1	9	9
29	R:R:I27	R:R:L53	4.28	No	No	0	7	7
30	R:R:A30	R:R:L46	3.15	No	No	0	6	6
31	R:R:H33	R:R:L42	3.86	No	Yes	5	4	7
32	R:R:H33	R:R:Y278	13.07	No	Yes	5	4	7
33	R:R:L38	R:R:V43	2.98	No	No	0	5	7
34	R:R:L38	R:R:P120	9.85	No	No	0	5	4
35	R:R:P40	R:R:T39	3.5	No	No	0	7	7
36	R:R:L42	R:R:T39	4.42	Yes	No	0	7	7
37	R:R:P40	R:R:Y114	4.17	No	Yes	0	7	6
38	R:R:P40	R:R:S123	7.13	No	No	0	7	8
39	R:R:L100	R:R:S41	3	No	No	0	8	7
40	R:R:S41	R:R:Y278	5.09	No	Yes	0	7	7
41	R:R:L42	R:R:Y278	9.38	Yes	Yes	5	7	7
42	R:R:S123	R:R:V43	6.46	No	No	0	8	7
43	R:R:V43	R:R:W124	14.71	No	No	0	7	4
44	R:R:A99	R:R:Y44	5.34	No	Yes	0	6	7
45	R:R:L100	R:R:Y44	8.21	No	Yes	0	8	7
46	R:R:S123	R:R:Y44	3.82	No	Yes	0	8	7
47	R:R:C127	R:R:Y44	2.69	No	Yes	0	7	7
48	R:R:F96	R:R:N47	8.46	Yes	No	4	6	9
49	R:R:C127	R:R:N47	6.3	No	No	4	7	9
50	R:R:N47	R:R:W131	10.17	No	Yes	4	9	9
51	R:R:L48	R:R:L97	6.92	No	No	0	9	8
52	R:R:P89	R:R:S51	3.56	No	No	0	8	8
53	R:R:S51	R:R:W131	3.71	No	Yes	0	8	9
54	R:R:D52	R:R:T56	2.89	Yes	Yes	1	9	6
55	R:R:D52	R:R:V269	5.84	Yes	Yes	1	9	7
56	R:R:D52	R:R:N272	4.04	Yes	No	0	9	9
57	R:R:D52	R:R:P273	6.44	Yes	No	1	9	9
58	R:R:L55	R:R:S58	6.01	Yes	No	1	7	7
59	R:R:L55	R:R:L59	2.77	Yes	No	1	7	9
60	R:R:H86	R:R:L55	5.14	Yes	Yes	1	6	7
61	R:R:L55	R:R:P89	13.14	Yes	No	0	7	8
62	R:R:L55	R:R:L90	2.77	Yes	No	0	7	7
63	R:R:L55	R:R:V269	2.98	Yes	Yes	1	7	7
64	R:R:T56	R:R:V269	6.35	Yes	Yes	1	6	7
65	R:R:H86	R:R:S58	9.76	Yes	No	1	6	7
66	R:R:L59	R:R:V269	4.47	No	Yes	1	9	7
67	R:R:L61	R:R:W72	3.42	No	Yes	0	6	9
68	R:R:F82	R:R:L61	15.83	No	No	0	5	6
69	R:R:E65	R:R:K62	10.8	No	No	0	7	7
70	R:R:H86	R:R:K62	17.03	Yes	No	0	6	7
71	R:R:E65	R:R:W72	15.27	No	Yes	0	7	9
72	R:R:L74	R:R:W72	10.25	No	Yes	2	7	9
73	R:R:C79	R:R:W72	10.45	Yes	Yes	2	9	9
74	R:R:C170	R:R:W72	16.98	No	Yes	2	9	9
75	R:R:L74	R:R:P75	4.93	No	No	2	7	8
76	R:R:L74	R:R:L78	5.54	No	No	2	7	5
77	R:R:L78	R:R:P75	6.57	No	No	2	5	8
78	R:R:A76	R:R:S157	3.42	No	No	0	3	2
79	R:R:C79	R:R:P80	3.77	Yes	No	0	9	7
80	R:R:C79	R:R:I160	6.55	Yes	No	0	9	2
81	R:R:C170	R:R:C79	3.64	No	Yes	2	9	9
82	R:R:F142	R:R:P80	4.33	Yes	No	0	4	7
83	R:R:A83	R:R:L171	3.15	No	No	0	6	5
84	R:R:L138	R:R:V84	4.47	No	No	0	6	6
85	R:R:F87	R:R:H86	3.39	No	Yes	1	6	6
86	R:R:F87	R:R:Y240	5.16	No	Yes	1	6	8
87	R:R:F88	R:R:P89	7.22	Yes	No	0	5	8
88	R:R:F88	R:R:W131	6.01	Yes	Yes	0	5	9
89	R:R:F88	R:R:V134	5.24	Yes	No	0	5	7
90	R:R:F88	R:R:L135	3.65	Yes	No	0	5	3
91	R:R:L190	R:R:Y91	5.86	No	No	0	6	8
92	R:R:Y240	R:R:Y91	8.94	Yes	No	1	8	8
93	R:R:A92	R:R:V134	5.09	No	No	0	6	7
94	R:R:F96	R:R:G93	6.02	Yes	No	0	6	9
95	R:R:G94	R:R:L97	5.13	No	No	0	8	8
96	R:R:G95	R:R:P194	4.06	No	No	0	5	9
97	R:R:C127	R:R:F96	4.19	No	Yes	4	7	6
98	R:R:F96	R:R:I130	6.28	Yes	No	0	6	6
99	R:R:F96	R:R:W131	15.03	Yes	Yes	4	6	9
100	R:R:A229	R:R:L97	3.15	No	No	0	8	8
101	R:R:L100	R:R:R104	10.93	No	No	0	8	9
102	R:R:S101	R:R:T198	4.8	No	No	0	9	8
103	R:R:R104	R:R:T276	3.88	No	No	0	9	7
104	R:R:A109	R:R:Y105	5.34	No	Yes	0	8	7
105	R:R:F200	R:R:Y105	3.09	No	Yes	0	4	7
106	R:R:C201	R:R:Y105	5.38	No	Yes	0	7	7
107	R:R:G204	R:R:Y105	4.35	No	Yes	0	4	7
108	R:R:L106	R:R:Y114	8.21	No	Yes	0	7	6
109	R:R:A108	R:R:C205	3.61	No	No	0	8	7
110	R:R:A109	R:R:F110	8.32	No	No	0	8	6
111	R:R:R118	R:R:Y114	9.26	No	Yes	0	8	6
112	R:R:Q115	R:R:R118	5.84	No	No	0	5	8
113	R:R:A116	R:R:F117	4.16	No	No	0	3	4
114	R:R:P120	R:R:R119	2.88	No	No	0	4	5
115	R:R:C121	R:R:R119	2.79	No	No	6	4	5
116	R:R:R119	R:R:Y122	5.14	No	No	6	5	3
117	R:R:C121	R:R:Y122	4.03	No	No	6	4	3
118	R:R:H137	R:R:L133	5.14	No	No	0	5	5
119	R:R:L133	R:R:L190	2.77	No	No	0	5	6
120	R:R:L138	R:R:V134	2.98	No	No	0	6	7
121	R:R:H137	R:R:L189	6.43	No	No	0	5	5
122	R:R:L186	R:R:V141	10.43	No	No	0	6	5
123	R:R:F142	R:R:L158	8.53	Yes	No	0	4	1
124	R:R:E145	R:R:N161	3.94	No	No	7	4	3
125	R:R:E145	R:R:W174	18.54	No	Yes	7	4	4
126	R:R:N161	R:R:W174	3.39	No	Yes	7	3	4
127	R:R:P163	R:R:T162	3.5	No	No	0	4	2
128	R:R:P163	R:R:V169	3.53	No	No	0	4	5
129	R:R:A173	R:R:V169	5.09	No	No	0	5	5
130	R:R:C170	R:R:L171	3.17	No	No	0	9	5
131	R:R:E172	R:R:R258	3.49	No	Yes	0	6	7
132	R:R:S178	R:R:W174	9.88	No	Yes	0	1	4
133	R:R:A179	R:R:W174	3.89	No	Yes	0	4	4
134	R:R:D175	R:R:P176	6.44	No	No	0	6	1
135	R:R:A177	R:R:D175	4.63	No	No	0	1	6
136	R:R:D175	R:R:S178	5.89	No	No	0	6	1
137	R:R:A179	R:R:R183	4.15	No	Yes	0	4	6
138	R:R:G180	R:R:P181	4.06	No	No	8	3	4
139	R:R:F248	R:R:G180	3.01	Yes	No	8	5	3
140	R:R:F248	R:R:P181	2.89	Yes	No	8	5	4
141	R:R:N244	R:R:R183	7.23	Yes	Yes	1	7	6
142	R:R:R183	R:R:R258	19.19	Yes	Yes	1	6	7
143	R:R:F184	R:R:V245	3.93	No	No	0	4	5
144	R:R:F184	R:R:F248	31.08	No	Yes	0	4	5
145	R:R:N241	R:R:S187	8.94	No	No	0	9	5
146	R:R:N244	R:R:S187	5.96	Yes	No	0	7	5
147	R:R:F192	R:R:L188	4.87	No	No	0	4	4
148	R:R:F191	R:R:F192	9.65	Yes	No	0	9	4
149	R:R:F191	R:R:L195	3.65	Yes	No	3	9	6
150	R:R:F191	R:R:L233	3.65	Yes	No	3	9	9
151	R:R:F191	R:R:V237	5.24	Yes	No	3	9	8
152	R:R:F191	R:R:G238	4.52	Yes	No	0	9	4
153	R:R:F191	R:R:N241	22.96	Yes	No	3	9	9
154	R:R:L193	R:R:P194	3.28	No	No	0	4	9
155	R:R:I197	R:R:L193	4.28	No	No	0	6	4
156	R:R:L195	R:R:L233	5.54	No	No	3	6	9
157	R:R:L195	R:R:L234	2.77	No	No	0	6	5
158	R:R:L233	R:R:T198	4.42	No	No	0	9	8
159	R:R:L206	R:R:Y202	9.38	No	No	0	5	8
160	R:R:G227	R:R:Y202	5.79	No	No	0	4	8
161	R:R:L230	R:R:Y202	3.52	No	No	0	8	8
162	R:R:R207	R:R:R211	11.73	No	No	0	4	4
163	R:R:G213	R:R:K219	6.97	No	No	0	4	6
164	R:R:L214	R:R:T215	2.95	No	No	0	3	3
165	R:R:R218	R:R:T215	5.17	No	No	0	5	3
166	R:R:H216	R:R:L220	5.14	No	No	0	2	4
167	R:R:R221	R:R:V225	5.23	No	No	0	7	7
168	R:R:G228	R:R:V275	5.52	No	No	0	5	7
169	R:R:L230	R:R:L234	8.3	No	No	0	8	5
170	R:R:L231	R:R:L235	2.77	No	No	0	5	5
171	R:R:C236	R:R:T232	3.38	Yes	No	9	8	6
172	R:R:L271	R:R:T232	2.95	No	No	9	6	6
173	R:R:N272	R:R:T232	7.31	No	No	0	9	6
174	R:R:C236	R:R:S268	3.44	Yes	Yes	0	8	9
175	R:R:C236	R:R:L271	3.17	Yes	No	9	8	6
176	R:R:N241	R:R:V237	2.96	No	No	3	9	8
177	R:R:S268	R:R:V237	3.23	Yes	No	0	9	8
178	R:R:G238	R:R:P239	4.06	No	No	0	4	9
179	R:R:P239	R:R:T264	10.49	No	No	0	9	5
180	R:R:N244	R:R:Y240	11.63	Yes	Yes	1	7	8
181	R:R:R258	R:R:Y240	8.23	Yes	Yes	1	7	8
182	R:R:G261	R:R:Y240	4.35	No	Yes	0	6	8
183	R:R:N244	R:R:R258	7.23	Yes	Yes	1	7	7
184	R:R:F248	R:R:L249	4.87	Yes	No	0	5	4
185	R:R:N252	R:R:Y250	3.49	No	No	0	1	2
186	R:R:L253	R:R:N252	2.75	No	No	0	3	1
187	R:R:L253	R:R:W257	9.11	No	No	0	3	5
188	R:R:N272	R:R:S268	5.96	No	Yes	0	9	9
189	R:R:T276	R:R:V275	3.17	No	No	0	7	7
190	R:R:A266	R:R:Y12	2.67	No	Yes	0	6	9
191	R:R:A45	R:R:Y278	2.67	No	Yes	0	7	7
192	R:R:F9	R:R:V64	2.62	Yes	No	0	6	4
193	R:R:F192	R:R:V245	2.62	No	No	0	4	5
194	R:R:C236	R:R:W267	2.61	Yes	No	0	8	4
195	R:R:F16	R:R:T56	2.59	No	Yes	0	6	6
196	R:R:F20	R:R:T56	2.59	No	Yes	0	5	6
197	R:R:A246	R:R:W257	2.59	No	No	0	5	5
198	R:R:S243	R:R:W257	2.47	No	No	0	5	5
199	R:R:L144	R:R:W174	2.28	No	Yes	0	3	4
200	R:R:G93	R:R:G94	2.11	No	No	0	9	8
201	R:R:G94	R:R:G95	2.11	No	No	0	8	5
202	R:R:G254	R:R:G255	2.11	No	No	0	6	5
203	R:R:G19	R:R:P21	2.03	No	No	0	8	5
204	R:R:R221	R:R:W224	2	No	No	0	7	5
205	R:R:P4	R:R:P5	1.95	No	No	0	6	7
206	R:R:A32	R:R:G29	1.95	No	No	0	3	7
207	R:R:A98	R:R:G95	1.95	No	No	0	7	5
208	R:R:A102	R:R:G103	1.95	No	No	0	6	8
209	R:R:A128	R:R:G125	1.95	No	No	0	4	1
210	R:R:A146	R:R:P147	1.87	No	No	0	3	3
211	R:R:G265	R:R:S268	1.86	No	Yes	0	8	9
212	R:R:G10	R:R:V13	1.84	No	No	0	5	6
213	R:R:G204	R:R:V203	1.84	No	No	0	4	3
214	R:R:A102	R:R:C201	1.81	No	No	0	6	7
215	R:R:A15	R:R:A266	1.79	No	No	0	7	6
216	R:R:A68	R:R:A71	1.79	No	No	0	3	4
217	R:R:A108	R:R:A208	1.79	No	No	0	8	5
218	R:R:P5	R:R:S69	1.78	No	No	0	7	4
219	R:R:P168	R:R:S167	1.78	No	No	0	4	3
220	R:R:G49	R:R:I27	1.76	No	No	0	8	7
221	R:R:P168	R:R:T162	1.75	No	No	0	4	2
222	R:R:C50	R:R:S51	1.72	No	No	0	4	8
223	R:R:C201	R:R:S101	1.72	No	No	0	7	9
224	R:R:G113	R:R:L112	1.71	No	No	0	4	6
225	R:R:G159	R:R:L158	1.71	No	No	0	4	1
226	R:R:G159	R:R:L171	1.71	No	No	0	4	5
227	R:R:G228	R:R:L231	1.71	No	No	0	5	5
228	R:R:G254	R:R:L253	1.71	No	No	0	6	3
229	R:R:A99	R:R:V126	1.7	No	No	0	6	5
230	R:R:A182	R:R:V141	1.7	No	No	0	4	5
231	R:R:I160	R:R:P168	1.69	No	No	0	2	4
232	R:R:S243	R:R:S247	1.63	No	No	0	5	6
233	R:R:A76	R:R:I160	1.62	No	No	0	3	2
234	R:R:A210	R:R:K219	1.61	No	No	0	2	6
235	R:R:G29	R:R:H33	1.59	No	No	0	7	4
236	R:R:C136	R:R:L140	1.59	No	No	0	4	7
237	R:R:C205	R:R:L206	1.59	No	No	0	7	5
238	R:R:A26	R:R:L279	1.58	No	No	0	9	5
239	R:R:A30	R:R:L42	1.58	No	Yes	0	6	7
240	R:R:A34	R:R:L38	1.58	No	No	0	5	5
241	R:R:A34	R:R:L42	1.58	No	Yes	0	5	7
242	R:R:A85	R:R:L54	1.58	No	No	0	5	7
243	R:R:A146	R:R:L158	1.58	No	No	0	3	1
244	R:R:A199	R:R:L230	1.58	No	No	0	4	8
245	R:R:A223	R:R:L206	1.58	No	No	0	5	5
246	R:R:A222	R:R:L209	1.58	No	No	0	8	8
247	R:R:E65	R:R:P73	1.57	No	No	0	7	4
248	R:R:K259	R:R:S256	1.53	No	No	0	3	1
249	R:R:I27	R:R:T31	1.52	No	No	0	7	1
250	R:R:F117	R:R:G113	1.51	No	No	0	4	4
251	R:R:F142	R:R:G139	1.51	Yes	No	0	4	4
252	R:R:L3	R:R:S8	1.5	Yes	No	0	7	3
253	R:R:G29	R:R:R28	1.5	No	No	0	7	2
254	R:R:G204	R:R:R207	1.5	No	No	0	4	4
255	R:R:L18	R:R:V270	1.49	No	No	0	6	6
256	R:R:L25	R:R:V24	1.49	No	No	0	5	3
257	R:R:N161	R:R:T156	1.46	No	No	0	3	1
258	R:R:G107	R:R:Y114	1.45	No	Yes	0	8	6
259	R:R:F110	R:R:P111	1.44	No	No	0	6	9
260	R:R:G125	R:R:W124	1.41	No	No	0	1	4
261	R:R:K219	R:R:L209	1.41	No	No	0	6	8
262	R:R:A17	R:R:F16	1.39	No	No	0	5	6
263	R:R:P251	R:R:Y250	1.39	No	No	0	2	2
264	R:R:L260	R:R:L3	1.38	No	Yes	0	3	7
265	R:R:L18	R:R:L22	1.38	No	No	0	6	7
266	R:R:A226	R:R:R104	1.38	No	No	0	7	9
267	R:R:L274	R:R:L279	1.38	No	No	0	6	5
268	R:R:A66	R:R:Y12	1.33	No	Yes	0	6	9
269	R:R:R258	R:R:S243	1.32	Yes	No	0	7	5
270	R:R:R217	R:R:T215	1.29	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.37143	7	1	0
2	R:R:L3	2.29	4	0	7
3	R:R:F9	4.765	4	0	6
4	R:R:Y12	3.50833	6	0	9
5	R:R:N23	7.6225	4	1	9
6	R:R:L42	4.164	5	5	7
7	R:R:Y44	5.015	4	0	7
8	R:R:D52	6.266	5	1	9
9	R:R:L55	5.46833	6	1	7
10	R:R:T56	4.054	5	1	6
11	R:R:W72	11.274	5	2	9
12	R:R:C79	6.1025	4	2	9
13	R:R:H86	8.83	4	1	6
14	R:R:F88	5.53	4	0	5
15	R:R:F96	7.996	5	4	6
16	R:R:Y105	4.54	4	0	7
17	R:R:Y114	5.7725	4	0	6
18	R:R:W131	8.73	4	4	9
19	R:R:F142	5.21	4	0	4
20	R:R:W174	7.596	5	7	4
21	R:R:R183	10.41	4	1	6
22	R:R:F191	8.27833	6	3	9
23	R:R:C236	3.15	4	9	8
24	R:R:Y240	7.12667	6	1	8
25	R:R:N244	8.0125	4	1	7
26	R:R:F248	10.4625	4	8	5
27	R:R:R258	7.5	6	1	7
28	R:R:S268	3.6225	4	0	9
29	R:R:V269	4.91	4	1	7
30	R:R:Y278	7.5525	4	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F87	26.4441	12.02	Yes	No	1	0	6
2	R:R:F87	R:R:H86	43.0018	3.39	No	Yes	1	6	6
3	R:R:H86	R:R:L55	56.9802	5.14	Yes	Yes	1	6	7
4	R:R:L55	R:R:L59	17.2423	2.77	Yes	No	1	7	9
5	R:R:L59	R:R:Y12	20.8625	3.52	No	Yes	0	9	9
6	R:R:I263	R:R:Y12	10.7787	4.84	No	Yes	0	6	9
7	R:R:L55	R:R:V269	48.4424	2.98	Yes	Yes	1	7	7
8	R:R:T56	R:R:V269	11.4478	6.35	Yes	Yes	1	6	7
9	R:R:D52	R:R:V269	40.8892	5.84	Yes	Yes	1	9	7
10	R:R:L55	R:R:P89	100	13.14	Yes	No	0	7	8
11	R:R:P89	R:R:S51	49.086	3.56	No	No	0	8	8
12	R:R:S51	R:R:W131	48.6296	3.71	No	Yes	0	8	9
13	R:R:N47	R:R:W131	43.2403	10.17	No	Yes	4	9	9
14	R:R:C127	R:R:N47	42.3583	6.3	No	No	4	7	9
15	R:R:C127	R:R:Y44	84.114	2.69	No	Yes	0	7	7
16	R:R:L100	R:R:Y44	36.3459	8.21	No	Yes	0	8	7
17	R:R:L100	R:R:S41	20.5497	3	No	No	0	8	7
18	R:R:S41	R:R:Y278	18.537	5.09	No	Yes	0	7	7
19	R:R:F88	R:R:P89	51.0243	7.22	Yes	No	0	5	8
20	R:R:F88	R:R:W131	49.6552	6.01	Yes	Yes	0	5	9
21	R:R:F96	R:R:W131	54.2471	15.03	Yes	Yes	4	6	9
22	R:R:C127	R:R:F96	43.6633	4.19	No	Yes	4	7	6
23	R:R:S123	R:R:Y44	42.7454	3.82	No	Yes	0	8	7
24	R:R:P40	R:R:S123	20.4036	7.13	No	No	0	7	8
25	R:R:S123	R:R:V43	20.6471	6.46	No	No	0	8	7
26	R:R:L38	R:R:V43	12.5144	2.98	No	No	0	5	7
27	R:R:P40	R:R:Y114	10.3248	4.17	No	Yes	0	7	6
28	R:R:F96	R:R:G93	11.0991	6.02	Yes	No	0	6	9
29	R:R:G93	R:R:G94	10.0121	2.11	No	No	0	9	8
30	R:R:D52	R:R:N272	33.1103	4.04	Yes	No	0	9	9
31	L:L:?1	R:R:F142	15.8578	6.47	Yes	Yes	0	0	4
32	R:R:H86	R:R:K62	16.6756	17.03	Yes	No	0	6	7
33	R:R:E65	R:R:K62	15.8578	10.8	No	No	0	7	7
34	R:R:C79	R:R:I160	10.7505	6.55	Yes	No	0	9	2
35	R:R:L100	R:R:R104	14.181	10.93	No	No	0	8	9
36	L:L:?1	R:R:R183	11.8093	11.07	Yes	Yes	1	0	6
37	R:R:N244	R:R:S187	16.4628	5.96	Yes	No	0	7	5
38	R:R:N241	R:R:S187	15.7014	8.94	No	No	0	9	5
39	R:R:F191	R:R:N241	13.0221	22.96	Yes	No	3	9	9
40	R:R:F191	R:R:L233	15.9193	3.65	Yes	No	3	9	9
41	R:R:L233	R:R:T198	15.2886	4.42	No	No	0	9	8
42	R:R:S101	R:R:T198	14.2297	4.8	No	No	0	9	8
43	L:L:?1	R:R:R258	12.6606	5.54	Yes	Yes	1	0	7
44	R:R:R104	R:R:T276	10.4428	3.88	No	No	0	9	7
45	R:R:C201	R:R:S101	13.1657	1.72	No	No	0	7	9
46	R:R:F191	R:R:L195	11.4632	3.65	Yes	No	3	9	6
47	R:R:L195	R:R:L234	10.812	2.77	No	No	0	6	5
48	R:R:S268	R:R:V237	28.7363	3.23	Yes	No	0	9	8
49	R:R:R258	R:R:S243	16.4321	1.32	Yes	No	0	7	5
50	R:R:S243	R:R:W257	13.1862	2.47	No	No	0	5	5
51	R:R:F87	R:R:Y240	16.1193	5.16	No	Yes	1	6	8
52	R:R:E65	R:R:W72	14.1143	15.27	No	Yes	0	7	9
53	R:R:N272	R:R:S268	29.7336	5.96	No	Yes	0	9	9
54	R:R:F191	R:R:V237	25.8954	5.24	Yes	No	3	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F87	12.02	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y91	8.9	1	Yes	No	0	8	0	1
L:L:?1	R:R:F142	6.47	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R183	11.07	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L186	3.15	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y240	4.45	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:R258	5.54	1	Yes	Yes	0	7	0	1
R:R:F142	R:R:P80	4.33	0	Yes	No	4	7	1	2
R:R:F87	R:R:H86	3.39	1	No	Yes	6	6	1	2
R:R:F87	R:R:Y240	5.16	1	No	Yes	6	8	1	1
R:R:L190	R:R:Y91	5.86	0	No	No	6	8	2	1
R:R:Y240	R:R:Y91	8.94	1	Yes	No	8	8	1	1
R:R:L186	R:R:V141	10.43	0	No	No	6	5	1	2
R:R:F142	R:R:L158	8.53	0	Yes	No	4	1	1	2
R:R:E172	R:R:R258	3.49	0	No	Yes	6	7	2	1
R:R:A179	R:R:R183	4.15	0	No	Yes	4	6	2	1
R:R:N244	R:R:R183	7.23	1	Yes	Yes	7	6	2	1
R:R:R183	R:R:R258	19.19	1	Yes	Yes	6	7	1	1
R:R:N244	R:R:Y240	11.63	1	Yes	Yes	7	8	2	1
R:R:R258	R:R:Y240	8.23	1	Yes	Yes	7	8	1	1
R:R:G261	R:R:Y240	4.35	0	No	Yes	6	8	2	1
R:R:N244	R:R:R258	7.23	1	Yes	Yes	7	7	2	1
R:R:F142	R:R:G139	1.51	0	Yes	No	4	4	1	2
R:R:R258	R:R:S243	1.32	1	Yes	No	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8EIT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.69
Number of Linked Nodes	250
Number of Links	270
Number of Hubs	30
Number of Links mediated by Hubs	118
Number of Communities	9
Number of Nodes involved in Communities	46
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	59352
Length Of Smallest Path	3
Average Path Length	14.5582
Length of Longest Path	28
Minimum Path Strength	1.435
Average Path Strength	6.14036
Maximum Path Strength	17.975
Minimum Path Correlation	0.7
Average Path Correlation	0.926938
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	49.4278
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7115
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of localization • regulation of calcium ion transport • positive regulation of calcium ion transport • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • calcium ion transport • metal ion transport • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • response to lipid • response to fatty acid • response to chemical • response to oxygen-containing compound • multicellular organismal process • interleukin-1 production • negative regulation of biological process • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-1 production • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • interleukin-1 beta production • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cell communication • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • ligand-gated ion channel signaling pathway • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • cell periphery • cellular anatomical structure • plasma membrane • membrane • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region • other organism part • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HXA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HXA
Name	Doconexent
Synonyms	4,7,10,13,16,19-docosahexaenoic acid
Identifier
Formula	C22 H32 O2
Molecular Weight	328.488
SMILES
PubChem	445580
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O14842
Sequence	>8EIT_nogp_Chain_R L P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R L T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S G A W P L P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F P L G Y Q A F R R P C Y S W G V C A A I W A L V L C H L G L V F G L E A P G T S L G I N T P V S P V C L E A W D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R S G L T H R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y P N L G G S W R K L G L I T G A W S V V L N P L V T G Y L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5KW2	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	PubChem 133053953	-	2.76	2018-05-02	doi.org/10.1038/s41467-017-01240-w
	5TZY	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666; AP8	-	3.22	2017-06-07	doi.org/10.1038/nsmb.3417
	5TZR	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	MK8666	-	2.2	2017-06-07	doi.org/10.1038/nsmb.3417
	4PHU	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	Fasiglifam	-	2.33	2014-07-16	doi.org/10.1038/nature13494
	9K1C	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA	Gi1/β1/γ2	3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	9K1C (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	-	DHA		3.2	2024-12-11	doi.org/10.1016/j.celrep.2024.115024
	8EIT	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EIT (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Doconexent	-		2.8	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJC (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8EJK (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	TAK-875	-		3.4	2023-05-24	doi.org/10.1073/pnas.2219569120
	8T3V	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384
	8T3V (No Gprot)	A	Lipid	Free Fatty Acid	FFA1	Homo sapiens	Docosa-4,7,10,13,16,19-Hexaenoic acid	-		3.39	2024-01-24	doi.org/10.1126/sciadv.adj2384

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