psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D23	R:R:K26	4.15	No	Yes	2	4	4
2	R:R:D23	R:R:R281	7.15	No	Yes	2	4	4
3	R:R:K26	R:R:Y27	27.47	Yes	No	0	4	4
4	R:R:K26	R:R:Y30	9.55	Yes	Yes	2	4	5
5	R:R:K26	R:R:R281	4.95	Yes	Yes	2	4	4
6	R:R:K26	R:R:P285	6.69	Yes	Yes	2	4	3
7	R:R:C289	R:R:L29	4.76	No	No	0	4	6
8	R:R:F34	R:R:Y30	3.09	Yes	Yes	0	7	5
9	R:R:F87	R:R:Y30	5.16	No	Yes	0	5	5
10	R:R:P285	R:R:Y30	5.56	Yes	Yes	2	3	5
11	R:R:L288	R:R:Y30	5.86	Yes	Yes	2	5	5
12	R:R:F87	R:R:S31	5.28	No	No	0	5	5
13	R:R:F34	R:R:V33	3.93	Yes	No	0	7	5
14	R:R:C289	R:R:V33	10.25	No	No	0	4	5
15	R:R:F34	R:R:L80	4.87	Yes	Yes	0	7	8
16	R:R:F34	R:R:R83	7.48	Yes	Yes	0	7	6
17	R:R:S35	R:R:V84	4.85	No	No	0	6	7
18	R:R:C296	R:R:V37	5.12	No	No	0	6	7
19	R:R:F38	R:R:L42	3.65	Yes	No	0	6	6
20	R:R:F38	R:R:L80	3.65	Yes	Yes	0	6	8
21	R:R:F38	R:R:P81	13	Yes	No	0	6	9
22	R:R:C296	R:R:V40	5.12	No	No	0	6	6
23	R:R:P299	R:R:T44	3.5	No	No	0	9	7
24	R:R:N45	R:R:V70	5.91	No	Yes	0	9	8
25	R:R:D73	R:R:N45	5.39	Yes	No	0	9	9
26	R:R:N45	R:R:P299	3.26	No	No	0	9	9
27	R:R:C54	R:R:Y50	4.03	No	No	0	4	3
28	R:R:F52	R:R:T63	3.89	Yes	No	0	6	8
29	R:R:F52	R:R:M66	6.22	Yes	Yes	1	6	8
30	R:R:F52	R:R:M67	3.73	Yes	No	0	6	5
31	R:R:F52	R:R:Y302	6.19	Yes	Yes	1	6	9
32	R:R:L56	R:R:R59	7.29	No	No	0	6	7
33	R:R:R59	R:R:T63	3.88	No	No	0	7	8
34	R:R:I309	R:R:R59	10.02	No	No	0	8	7
35	R:R:E61	R:R:N60	11.83	No	No	0	6	7
36	R:R:I309	R:R:N60	11.33	No	No	0	8	7
37	R:R:D123	R:R:E61	6.5	Yes	No	4	8	6
38	R:R:E61	R:R:R138	9.3	No	Yes	4	6	7
39	R:R:D123	R:R:T62	8.67	Yes	No	0	8	7
40	R:R:R124	R:R:T62	5.17	Yes	No	0	9	7
41	R:R:K140	R:R:T64	4.5	Yes	No	0	3	6
42	R:R:A143	R:R:T64	3.36	No	No	0	7	6
43	R:R:C119	R:R:Y65	6.72	No	Yes	4	6	7
44	R:R:D123	R:R:Y65	4.6	Yes	Yes	4	8	7
45	R:R:A143	R:R:Y65	5.34	No	Yes	0	7	7
46	R:R:V146	R:R:Y65	7.57	No	Yes	0	5	7
47	L:L:?1	R:R:Y65	10.34	Yes	Yes	4	0	7
48	R:R:M66	R:R:Y302	11.97	Yes	Yes	1	8	9
49	R:R:M66	R:R:T305	4.52	Yes	No	0	8	6
50	R:R:M66	R:R:S306	3.07	Yes	No	0	8	8
51	R:R:F116	R:R:N68	10.87	Yes	No	1	7	9
52	R:R:C147	R:R:N68	11.02	No	No	0	7	9
53	R:R:N68	R:R:W151	6.78	No	Yes	1	9	9
54	R:R:F116	R:R:L69	8.53	Yes	No	1	7	9
55	R:R:D298	R:R:L69	9.5	Yes	No	1	9	9
56	R:R:L69	R:R:Y302	10.55	No	Yes	1	9	9
57	R:R:V70	R:R:Y302	3.79	Yes	Yes	0	8	9
58	R:R:V71	R:R:W151	3.68	No	Yes	0	6	9
59	R:R:S72	R:R:W151	3.71	No	Yes	0	8	9
60	R:R:D73	R:R:N109	6.73	Yes	No	0	9	8
61	R:R:D73	R:R:N294	8.08	Yes	Yes	1	9	9
62	R:R:C295	R:R:D73	4.67	No	Yes	0	8	9
63	R:R:D298	R:R:D73	6.65	Yes	Yes	1	9	9
64	R:R:F76	R:R:T79	3.89	Yes	No	0	7	6
65	R:R:F76	R:R:L80	3.65	Yes	Yes	0	7	8
66	R:R:F76	R:R:R83	3.21	Yes	Yes	2	7	6
67	R:R:F106	R:R:F76	6.43	Yes	Yes	2	6	7
68	R:R:F76	R:R:N109	13.29	Yes	No	0	7	8
69	R:R:F76	R:R:V292	5.24	Yes	No	0	7	7
70	R:R:C295	R:R:V77	3.42	No	No	0	8	5
71	R:R:L105	R:R:T79	4.42	No	No	0	5	6
72	R:R:L82	R:R:W92	3.42	No	Yes	3	5	8
73	R:R:F94	R:R:L82	8.53	Yes	No	3	7	5
74	R:R:F87	R:R:R83	4.28	No	Yes	0	5	6
75	R:R:F106	R:R:R83	6.41	Yes	Yes	2	6	6
76	R:R:F85	R:R:Q89	7.03	No	No	0	4	3
77	R:R:W92	R:R:Y86	4.82	Yes	No	0	8	5
78	R:R:Q89	R:R:V88	8.6	No	No	0	3	4
79	R:R:N91	R:R:P93	6.52	No	No	0	4	3
80	R:R:F94	R:R:W92	21.05	Yes	Yes	3	7	8
81	R:R:C99	R:R:W92	3.92	Yes	Yes	3	9	8
82	R:R:I176	R:R:W92	4.7	No	Yes	0	3	8
83	R:R:C178	R:R:W92	19.59	No	Yes	3	9	8
84	R:R:F94	R:R:P93	7.22	Yes	No	0	7	3
85	R:R:F94	R:R:L98	6.09	Yes	No	0	7	5
86	R:R:K100	R:R:S96	4.59	Yes	No	0	7	3
87	R:R:S96	R:R:T168	7.99	No	No	0	3	2
88	R:R:C99	R:R:K100	4.85	Yes	Yes	3	9	7
89	R:R:C99	R:R:N166	6.3	Yes	Yes	3	9	4
90	R:R:C178	R:R:C99	7.28	No	Yes	3	9	9
91	R:R:F163	R:R:K100	7.44	No	Yes	0	5	7
92	R:R:K100	R:R:N166	4.2	Yes	Yes	3	7	4
93	R:R:K100	R:R:S167	9.18	Yes	No	0	7	5
94	R:R:L159	R:R:S104	6.01	No	No	0	4	4
95	R:R:L105	R:R:T108	4.42	No	Yes	0	5	5
96	R:R:F106	R:R:Y107	15.47	Yes	No	0	6	5
97	R:R:F106	R:R:Y256	5.16	Yes	Yes	2	6	6
98	R:R:F106	R:R:L288	4.87	Yes	Yes	2	6	5
99	R:R:T108	R:R:V154	4.76	Yes	No	0	5	7
100	R:R:L155	R:R:T108	4.42	No	Yes	0	3	5
101	R:R:S158	R:R:T108	6.4	No	Yes	0	7	5
102	R:R:N109	R:R:S113	5.96	No	No	0	8	9
103	R:R:M110	R:R:Y111	4.79	No	No	0	7	6
104	R:R:M110	R:R:Y256	8.38	No	Yes	0	7	6
105	R:R:I198	R:R:Y111	3.63	No	No	0	5	6
106	R:R:E199	R:R:Y111	11.22	Yes	No	0	5	6
107	R:R:N294	R:R:S113	7.45	Yes	No	0	9	9
108	R:R:I114	R:R:P206	3.39	No	No	0	7	9
109	R:R:F249	R:R:I114	3.77	Yes	No	1	9	7
110	R:R:F253	R:R:I114	15.07	Yes	No	1	8	7
111	R:R:L115	R:R:V150	5.96	No	No	0	5	7
112	L:L:?1	R:R:L115	3.66	Yes	No	0	0	5
113	R:R:F116	R:R:V150	13.11	Yes	No	0	7	7
114	R:R:F116	R:R:W151	6.01	Yes	Yes	1	7	9
115	R:R:F249	R:R:L117	4.87	Yes	No	0	9	8
116	R:R:D298	R:R:L117	4.07	Yes	No	0	9	8
117	R:R:P206	R:R:T118	6.99	No	No	0	9	8
118	R:R:N210	R:R:T118	10.24	Yes	No	0	7	8
119	L:L:?1	R:R:C119	8.4	Yes	No	4	0	6
120	R:R:N210	R:R:S121	7.45	Yes	No	1	7	9
121	R:R:H245	R:R:S121	9.76	No	No	1	7	9
122	L:L:?1	R:R:V122	10.51	Yes	No	0	0	6
123	R:R:D123	R:R:R138	3.57	Yes	Yes	4	8	7
124	L:L:?1	R:R:D123	4.79	Yes	Yes	4	0	8
125	R:R:A127	R:R:R124	5.53	No	Yes	0	8	9
126	R:R:M241	R:R:R124	4.96	Yes	Yes	5	7	9
127	R:R:R124	R:R:T308	9.06	Yes	No	5	9	5
128	R:R:Q310	R:R:R124	8.18	No	Yes	0	8	9
129	R:R:F125	R:R:L126	4.87	Yes	No	0	8	5
130	R:R:F125	R:R:V129	6.55	Yes	No	6	8	7
131	R:R:F125	R:R:Y130	3.09	Yes	No	6	8	6
132	R:R:C213	R:R:F125	9.78	No	Yes	0	6	8
133	R:R:F125	R:R:M216	8.71	Yes	No	0	8	4
134	R:R:L126	R:R:S134	9.01	No	No	0	5	6
135	R:R:A127	R:R:R138	5.53	No	Yes	0	8	7
136	R:R:I128	R:R:V217	3.07	No	No	0	8	8
137	R:R:I128	R:R:I238	7.36	No	No	0	8	8
138	R:R:V129	R:R:Y130	7.57	No	No	6	7	6
139	R:R:T220	R:R:V129	6.35	No	No	0	5	7
140	R:R:F132	R:R:P131	10.11	No	No	0	6	8
141	R:R:R138	R:R:S134	7.91	Yes	No	0	7	6
142	R:R:N142	R:R:T139	5.85	No	No	0	4	6
143	R:R:K140	R:R:K144	8.62	Yes	No	0	3	4
144	R:R:N142	R:R:R141	9.64	No	No	0	4	4
145	R:R:I145	R:R:R141	3.76	No	No	0	3	4
146	R:R:L155	R:R:W151	5.69	No	Yes	0	3	9
147	R:R:G162	R:R:T161	3.64	No	No	0	3	4
148	R:R:C178	R:R:N166	6.3	No	Yes	3	9	4
149	R:R:F179	R:R:N166	4.83	No	Yes	0	4	4
150	R:R:N169	R:R:T168	4.39	No	No	0	3	2
151	R:R:E172	R:R:N169	15.77	No	No	0	2	3
152	R:R:K170	R:R:S177	6.12	No	No	0	1	3
153	R:R:L171	R:R:N173	6.87	No	No	0	3	3
154	R:R:L171	R:R:S175	4.5	No	No	0	3	2
155	R:R:E172	R:R:I176	9.56	No	No	0	2	3
156	R:R:F179	R:R:S177	3.96	No	No	0	4	3
157	R:R:E186	R:R:K188	16.2	No	No	7	2	2
158	R:R:E186	R:R:R267	16.28	No	Yes	7	2	4
159	R:R:H190	R:R:W187	3.17	No	No	0	3	2
160	R:R:K188	R:R:R267	9.9	No	Yes	7	2	4
161	R:R:S192	R:R:S264	4.89	No	No	0	3	5
162	R:R:I196	R:R:S264	4.64	No	No	0	4	5
163	R:R:F197	R:R:V201	3.93	No	No	0	3	4
164	R:R:E199	R:R:N257	13.15	Yes	No	0	5	7
165	R:R:E199	R:R:L260	3.98	Yes	Yes	0	5	6
166	R:R:F203	R:R:I254	3.77	No	Yes	0	8	6
167	R:R:F203	R:R:N257	24.17	No	No	0	8	7
168	R:R:I205	R:R:P206	5.08	No	No	0	5	9
169	R:R:F249	R:R:L207	6.09	Yes	No	0	9	7
170	R:R:I254	R:R:L207	4.28	Yes	No	0	6	7
171	R:R:H245	R:R:N210	7.65	No	Yes	1	7	7
172	R:R:F249	R:R:N210	9.67	Yes	Yes	1	9	7
173	R:R:I242	R:R:S214	6.19	Yes	No	0	7	9
174	R:R:L246	R:R:S214	7.51	No	No	0	7	9
175	R:R:I242	R:R:V217	4.61	Yes	No	0	7	8
176	R:R:I242	R:R:L218	7.14	Yes	No	0	7	4
177	R:R:I238	R:R:L221	5.71	No	No	0	8	8
178	R:R:K235	R:R:T226	6.01	No	No	0	7	2
179	R:R:K237	R:R:N234	16.79	No	No	0	7	5
180	R:R:K236	R:R:L239	7.05	No	No	0	5	6
181	R:R:K236	R:R:R240	14.85	No	No	0	5	5
182	R:R:E307	R:R:K237	12.15	No	No	0	6	7
183	R:R:I243	R:R:L239	4.28	No	No	0	5	6
184	R:R:F304	R:R:R240	3.21	No	No	0	7	5
185	R:R:M241	R:R:T305	6.02	Yes	No	0	7	6
186	R:R:M241	R:R:T308	10.54	Yes	No	5	7	5
187	R:R:I248	R:R:V244	3.07	Yes	No	0	6	5
188	R:R:F304	R:R:V244	6.55	No	No	0	7	5
189	R:R:F297	R:R:I248	3.77	Yes	Yes	0	6	6
190	R:R:I248	R:R:V301	4.61	Yes	No	0	6	7
191	R:R:F249	R:R:F253	5.36	Yes	Yes	1	9	8
192	R:R:C250	R:R:I254	4.91	No	Yes	0	5	6
193	R:R:F251	R:R:I290	8.79	No	No	0	6	7
194	R:R:F251	R:R:F297	3.22	No	Yes	0	6	6
195	R:R:C252	R:R:F253	4.19	No	Yes	0	7	8
196	R:R:C252	R:R:F297	4.19	No	Yes	0	7	6
197	R:R:F253	R:R:N294	6.04	Yes	Yes	1	8	9
198	R:R:I254	R:R:P255	3.39	Yes	No	0	6	9
199	R:R:N257	R:R:Y256	5.81	No	Yes	0	7	6
200	R:R:L260	R:R:Y256	9.38	Yes	Yes	2	6	6
201	R:R:Y256	R:R:Y284	10.92	Yes	Yes	2	6	5
202	R:R:L288	R:R:Y256	4.69	Yes	Yes	2	5	6
203	R:R:I283	R:R:N259	11.33	No	No	0	5	5
204	R:R:L260	R:R:Y284	3.52	Yes	Yes	2	6	5
205	R:R:V280	R:R:Y263	5.05	No	No	0	5	4
206	R:R:R281	R:R:Y263	5.14	Yes	No	0	4	4
207	R:R:T270	R:R:V266	4.76	No	No	0	1	3
208	R:R:E277	R:R:V266	4.28	No	No	0	4	3
209	R:R:V266	R:R:V280	3.21	No	No	0	3	5
210	R:R:K272	R:R:T270	7.51	No	No	0	1	1
211	R:R:A276	R:R:K272	3.21	No	No	0	1	1
212	R:R:I283	R:R:V279	3.07	No	No	0	5	2
213	R:R:R281	R:R:Y284	5.14	Yes	Yes	2	4	5
214	R:R:P285	R:R:R281	10.09	Yes	Yes	2	3	4
215	R:R:P285	R:R:Y284	4.17	Yes	Yes	2	3	5
216	R:R:L288	R:R:Y284	3.52	Yes	Yes	2	5	5
217	R:R:F297	R:R:S293	3.96	Yes	No	0	6	4
218	R:R:D298	R:R:N294	12.12	Yes	Yes	1	9	9
219	R:R:D298	R:R:Y302	10.34	Yes	Yes	1	9	9
220	R:R:F304	R:R:Y303	12.38	No	No	0	7	6
221	R:R:E307	R:R:Y303	12.35	No	No	0	6	6
222	R:R:L318	R:R:Y319	11.72	No	No	0	5	2
223	R:R:M49	R:R:V70	3.04	No	Yes	0	7	8
224	R:R:I120	R:R:T305	3.04	No	No	0	8	6
225	R:R:I196	R:R:T200	3.04	No	No	0	4	4
226	R:R:G136	R:R:R135	3	No	No	0	4	5
227	R:R:L80	R:R:V37	2.98	Yes	No	0	8	7
228	R:R:L42	R:R:V46	2.98	No	No	0	6	3
229	R:R:L74	R:R:V70	2.98	No	Yes	0	7	8
230	R:R:L75	R:R:V71	2.98	No	No	0	7	6
231	R:R:L209	R:R:V122	2.98	No	No	0	7	6
232	R:R:L191	R:R:V194	2.98	No	No	0	4	5
233	R:R:L260	R:R:V195	2.98	Yes	No	0	6	5
234	R:R:N166	R:R:V103	2.96	Yes	No	0	4	5
235	R:R:N259	R:R:V280	2.96	No	No	0	5	5
236	R:R:L233	R:R:T226	2.95	No	No	0	4	2
237	R:R:I248	R:R:I300	2.94	Yes	No	0	6	7
238	R:R:I242	R:R:M241	2.92	Yes	Yes	0	7	7
239	R:R:E199	R:R:V261	2.85	Yes	No	0	5	5
240	R:R:L165	R:R:M164	2.83	No	No	0	5	4
241	R:R:L204	R:R:M208	2.83	No	No	0	5	3
242	R:R:K140	R:R:L58	2.82	Yes	No	0	3	6
243	R:R:K235	R:R:L221	2.82	No	No	0	7	8
244	R:R:P28	R:R:Y27	2.78	No	No	0	3	4
245	R:R:L101	R:R:L105	2.77	No	No	0	5	5
246	R:R:L155	R:R:L159	2.77	No	No	0	3	4
247	R:R:L265	R:R:N269	2.75	Yes	No	0	4	4
248	R:R:N173	R:R:N174	2.72	No	No	0	3	6
249	R:R:A291	R:R:Y256	2.67	No	Yes	0	8	6
250	R:R:R223	R:R:T220	2.59	No	No	0	5	5
251	R:R:R267	R:R:T268	2.59	Yes	No	0	4	2
252	R:R:V103	R:R:Y107	2.52	No	No	0	5	5
253	R:R:F247	R:R:I243	2.51	No	No	0	5	5
254	R:R:S102	R:R:W92	2.47	No	Yes	0	5	8
255	R:R:F25	R:R:L29	2.44	No	No	0	3	6
256	R:R:F163	R:R:L97	2.44	No	No	0	5	1
257	R:R:F262	R:R:L265	2.44	No	Yes	0	4	4
258	R:R:Q90	R:R:Y86	2.25	No	No	0	4	5
259	R:R:F85	R:R:F94	2.14	No	Yes	0	4	7
260	R:R:F132	R:R:R133	2.14	No	No	0	6	4
261	R:R:R133	R:R:Y130	2.06	No	No	0	4	6
262	R:R:C296	R:R:G41	1.96	No	No	0	6	8
263	R:R:A276	R:R:G273	1.95	No	No	0	1	5
264	R:R:A287	R:R:P255	1.87	No	No	0	6	9
265	R:R:G162	R:R:S104	1.86	No	No	0	3	4
266	R:R:G112	R:R:V150	1.84	No	No	0	7	7
267	R:R:G112	R:R:V154	1.84	No	No	0	7	7
268	R:R:L159	R:R:P160	1.64	No	No	0	4	8
269	R:R:C54	R:R:M53	1.62	No	No	0	4	2
270	R:R:S156	R:R:V152	1.62	No	No	0	4	4
271	R:R:V84	R:R:V88	1.6	No	No	0	7	4
272	R:R:S278	R:R:T282	1.6	No	No	0	3	2
273	R:R:T226	R:R:V227	1.59	No	No	0	2	3
274	R:R:I36	R:R:V40	1.54	No	No	0	5	6
275	R:R:I254	R:R:V258	1.54	Yes	No	0	6	5
276	R:R:K193	R:R:S189	1.53	No	No	0	3	2
277	R:R:M216	R:R:V212	1.52	No	No	0	4	4
278	R:R:A215	R:R:Q219	1.52	No	No	0	1	4
279	R:R:I283	R:R:T282	1.52	No	No	0	5	2
280	R:R:F94	R:R:G95	1.51	Yes	No	0	7	8
281	R:R:L56	R:R:S55	1.5	No	No	0	6	5
282	R:R:L137	R:R:S134	1.5	No	No	0	4	6
283	R:R:K140	R:R:T139	1.5	Yes	No	0	3	6
284	R:R:L265	R:R:S264	1.5	Yes	No	0	4	5
285	R:R:L78	R:R:V77	1.49	No	No	0	5	5
286	R:R:L265	R:R:V261	1.49	Yes	No	0	4	5
287	R:R:L165	R:R:T161	1.47	No	No	0	5	4
288	R:R:I286	R:R:I290	1.47	No	No	0	5	7
289	R:R:I36	R:R:M32	1.46	No	No	0	5	5
290	R:R:M49	R:R:M53	1.44	No	No	0	7	2
291	R:R:M53	R:R:M67	1.44	No	No	0	2	5
292	R:R:P224	R:R:R223	1.44	No	No	0	6	5
293	R:R:E316	R:R:S315	1.44	No	No	0	3	6
294	R:R:A48	R:R:F52	1.39	No	Yes	0	8	6
295	R:R:L165	R:R:L191	1.38	No	No	0	5	4
296	R:R:L204	R:R:L207	1.38	No	No	0	5	7
297	R:R:L56	R:R:N311	1.37	No	No	0	6	5
298	R:R:M216	R:R:Q219	1.36	No	No	0	4	4
299	R:R:H190	R:R:L191	1.29	No	No	0	3	4
300	R:R:F197	R:R:I198	1.26	No	No	0	3	5
301	R:R:F38	R:R:M39	1.24	Yes	No	0	6	5
302	R:R:E277	R:R:R267	1.16	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K26	10.562	5	2	4
2	R:R:Y30	5.844	5	2	5
3	R:R:F34	4.8425	4	0	7
4	R:R:F38	5.385	4	0	6
5	R:R:F52	4.284	5	1	6
6	R:R:Y65	6.914	5	4	7
7	R:R:M66	6.445	4	1	8
8	R:R:V70	3.93	4	0	8
9	R:R:D73	6.304	5	1	9
10	R:R:F76	5.95167	6	2	7
11	R:R:L80	3.7875	4	0	8
12	R:R:R83	5.345	4	2	6
13	R:R:W92	8.56714	7	3	8
14	R:R:F94	7.75667	6	3	7
15	R:R:C99	5.5875	4	3	9
16	R:R:K100	6.052	5	3	7
17	R:R:F106	7.668	5	2	6
18	R:R:T108	5	4	0	5
19	R:R:F116	9.63	4	1	7
20	R:R:D123	5.626	5	4	8
21	R:R:R124	6.58	5	5	9
22	R:R:F125	6.6	5	6	8
23	R:R:R138	6.5775	4	4	7
24	R:R:K140	4.36	4	0	3
25	R:R:W151	5.174	5	1	9
26	R:R:N166	4.918	5	3	4
27	R:R:E199	7.8	4	0	5
28	R:R:N210	8.7525	4	1	7
29	R:R:M241	6.11	4	5	7
30	R:R:I242	5.215	4	0	7
31	R:R:I248	3.5975	4	0	6
32	R:R:F249	5.952	5	1	9
33	R:R:F253	7.665	4	1	8
34	R:R:I254	3.578	5	0	6
35	R:R:Y256	6.71571	7	2	6
36	R:R:L260	4.965	4	2	6
37	R:R:L265	2.045	4	0	4
38	R:R:R267	7.4825	4	7	4
39	R:R:R281	6.494	5	2	4
40	R:R:Y284	5.454	5	2	5
41	R:R:P285	6.6275	4	2	3
42	R:R:L288	4.735	4	2	5
43	R:R:N294	8.4225	4	1	9
44	R:R:F297	3.785	4	0	6
45	R:R:D298	8.536	5	1	9
46	R:R:Y302	8.568	5	1	9
47	L:L:?1	7.54	5	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K26	R:R:Y30	14.8896	9.55	Yes	Yes	2	4	5
2	R:R:F34	R:R:Y30	13.0775	3.09	Yes	Yes	0	7	5
3	R:R:R281	R:R:Y284	39.7492	5.14	Yes	Yes	2	4	5
4	R:R:L288	R:R:Y284	19.9538	3.52	Yes	Yes	2	5	5
5	R:R:F34	R:R:L80	11.007	4.87	Yes	Yes	0	7	8
6	R:R:F34	R:R:R83	10.5247	7.48	Yes	Yes	0	7	6
7	R:R:F106	R:R:L288	26.0344	4.87	Yes	Yes	2	6	5
8	R:R:F106	R:R:Y107	59.4688	15.47	Yes	No	0	6	5
9	R:R:V103	R:R:Y107	58.418	2.52	No	No	0	5	5
10	R:R:N166	R:R:V103	57.3432	2.96	Yes	No	0	4	5
11	R:R:C99	R:R:N166	22.1793	6.3	Yes	Yes	3	9	4
12	R:R:C99	R:R:W92	21.3835	3.92	Yes	Yes	3	9	8
13	R:R:F94	R:R:W92	25.2145	21.05	Yes	Yes	3	7	8
14	R:R:F85	R:R:F94	12.671	2.14	No	Yes	0	4	7
15	R:R:F85	R:R:Q89	10.2077	7.03	No	No	0	4	3
16	R:R:Y256	R:R:Y284	23.3438	10.92	Yes	Yes	2	6	5
17	R:R:F106	R:R:Y256	47.1113	5.16	Yes	Yes	2	6	6
18	R:R:C178	R:R:N166	22.2448	6.3	No	Yes	3	9	4
19	R:R:C178	R:R:W92	21.0494	19.59	No	Yes	3	9	8
20	R:R:F76	R:R:L80	22.9132	3.65	Yes	Yes	0	7	8
21	R:R:F76	R:R:N109	96.5136	13.29	Yes	No	0	7	8
22	R:R:D73	R:R:N109	81.1865	6.73	Yes	No	0	9	8
23	R:R:F76	R:R:R83	15.9162	3.21	Yes	Yes	2	7	6
24	R:R:F106	R:R:F76	100	6.43	Yes	Yes	2	6	7
25	R:R:D298	R:R:D73	60.7538	6.65	Yes	Yes	1	9	9
26	R:R:D298	R:R:Y302	43.2012	10.34	Yes	Yes	1	9	9
27	R:R:F52	R:R:Y302	11.0449	6.19	Yes	Yes	1	6	9
28	R:R:M66	R:R:Y302	34.9433	11.97	Yes	Yes	1	8	9
29	R:R:F76	R:R:T79	38.6985	3.89	Yes	No	0	7	6
30	R:R:L105	R:R:T79	37.8647	4.42	No	No	0	5	6
31	R:R:L105	R:R:T108	36.4385	4.42	No	Yes	0	5	5
32	R:R:T108	R:R:V154	24.0466	4.76	Yes	No	0	5	7
33	R:R:G112	R:R:V154	23.8399	1.84	No	No	0	7	7
34	R:R:G112	R:R:V150	23.7159	1.84	No	No	0	7	7
35	R:R:L115	R:R:V150	55.3416	5.96	No	No	0	5	7
36	L:L:?1	R:R:L115	53.9808	3.66	Yes	No	0	0	5
37	L:L:?1	R:R:D123	31.2709	4.79	Yes	Yes	4	0	8
38	R:R:D298	R:R:L69	36.4523	9.5	Yes	No	1	9	9
39	R:R:F116	R:R:L69	40.3934	8.53	Yes	No	1	7	9
40	R:R:F116	R:R:V150	34.3714	13.11	Yes	No	0	7	7
41	R:R:D123	R:R:R138	28.1186	3.57	Yes	Yes	4	8	7
42	R:R:M66	R:R:T305	34.8572	4.52	Yes	No	0	8	6
43	R:R:M241	R:R:T305	33.2931	6.02	Yes	No	0	7	6
44	R:R:M241	R:R:R124	21.7556	4.96	Yes	Yes	5	7	9
45	R:R:A127	R:R:R124	17.5698	5.53	No	Yes	0	8	9
46	R:R:A127	R:R:R138	16.8877	5.53	No	Yes	0	8	7
47	L:L:?1	R:R:Y65	17.2391	10.34	Yes	Yes	4	0	7
48	R:R:A143	R:R:Y65	16.0885	5.34	No	Yes	0	7	7
49	R:R:A143	R:R:T64	14.328	3.36	No	No	0	7	6
50	R:R:K140	R:R:T64	12.5607	4.5	Yes	No	0	3	6
51	R:R:L155	R:R:T108	11.913	4.42	No	Yes	0	3	5
52	R:R:L155	R:R:W151	10.3214	5.69	No	Yes	0	3	9
53	R:R:D73	R:R:N294	16.2607	8.08	Yes	Yes	1	9	9
54	R:R:N109	R:R:S113	15.4408	5.96	No	No	0	8	9
55	R:R:N294	R:R:S113	15.334	7.45	Yes	No	0	9	9
56	R:R:L155	R:R:L159	12.3161	2.77	No	No	0	3	4
57	R:R:L159	R:R:S104	10.1319	6.01	No	No	0	4	4
58	R:R:E199	R:R:L260	10.0286	3.98	Yes	Yes	0	5	6
59	R:R:N257	R:R:Y256	16.6259	5.81	No	Yes	0	7	6
60	R:R:F203	R:R:N257	13.1154	24.17	No	No	0	8	7
61	R:R:F203	R:R:I254	13.1223	3.77	No	Yes	0	8	6
62	R:R:I254	R:R:L207	13.6907	4.28	Yes	No	0	6	7
63	R:R:F249	R:R:L207	14.5382	6.09	Yes	No	0	9	7
64	R:R:F253	R:R:N294	40.1557	6.04	Yes	Yes	1	8	9
65	R:R:D298	R:R:L117	13.2704	4.07	Yes	No	0	9	8
66	R:R:F249	R:R:L117	12.5642	4.87	Yes	No	0	9	8
67	R:R:R138	R:R:S134	42.867	7.91	Yes	No	0	7	6
68	R:R:L126	R:R:S134	37.9268	9.01	No	No	0	5	6
69	R:R:F125	R:R:L126	35.4463	4.87	Yes	No	0	8	5
70	R:R:F125	R:R:V129	10.2077	6.55	Yes	No	6	8	7
71	R:R:F125	R:R:Y130	10.2077	3.09	Yes	No	6	8	6
72	R:R:F125	R:R:M216	10.2629	8.71	Yes	No	0	8	4
73	R:R:I242	R:R:M241	13.8871	2.92	Yes	Yes	0	7	7
74	R:R:R281	R:R:Y263	38.1817	5.14	Yes	No	0	4	4
75	R:R:V280	R:R:Y263	35.9906	5.05	No	No	0	5	4
76	R:R:V266	R:R:V280	22.6996	3.21	No	No	0	3	5
77	R:R:E277	R:R:V266	11.4342	4.28	No	No	0	4	3
78	R:R:E199	R:R:V261	19.2614	2.85	Yes	No	0	5	5
79	R:R:L265	R:R:V261	16.8774	1.49	Yes	No	0	4	5
80	R:R:C252	R:R:F253	35.1363	4.19	No	Yes	0	7	8
81	R:R:C252	R:R:F297	33.4447	4.19	No	Yes	0	7	6
82	R:R:F297	R:R:I248	24.8837	3.77	Yes	Yes	0	6	6
83	R:R:I248	R:R:V244	19.6644	3.07	Yes	No	0	6	5
84	R:R:F304	R:R:V244	17.9109	6.55	No	No	0	7	5
85	R:R:N259	R:R:V280	11.4342	2.96	No	No	0	5	5
86	R:R:E199	R:R:N257	12.9466	13.15	Yes	No	0	5	7
87	R:R:L260	R:R:Y256	10.2766	9.38	Yes	Yes	2	6	6
88	R:R:D298	R:R:N294	11.0104	12.12	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D123	R:R:E61	6.5	4	Yes	No	8	6	1	2
R:R:E61	R:R:R138	9.3	4	No	Yes	6	7	2	2
R:R:D123	R:R:T62	8.67	4	Yes	No	8	7	1	2
R:R:C119	R:R:Y65	6.72	4	No	Yes	6	7	1	1
R:R:D123	R:R:Y65	4.6	4	Yes	Yes	8	7	1	1
R:R:A143	R:R:Y65	5.34	0	No	Yes	7	7	2	1
R:R:V146	R:R:Y65	7.57	0	No	Yes	5	7	2	1
L:L:?1	R:R:Y65	10.34	4	Yes	Yes	0	7	0	1
R:R:L115	R:R:V150	5.96	0	No	No	5	7	1	2
L:L:?1	R:R:L115	3.66	4	Yes	No	0	5	0	1
L:L:?1	R:R:C119	8.4	4	Yes	No	0	6	0	1
L:L:?1	R:R:V122	10.51	4	Yes	No	0	6	0	1
R:R:D123	R:R:R138	3.57	4	Yes	Yes	8	7	1	2
L:L:?1	R:R:D123	4.79	4	Yes	Yes	0	8	0	1
R:R:L209	R:R:V122	2.98	0	No	No	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
40.00	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
28.57	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
27.78	Single	5KW2	PubChem 133053953	5KW2-FFA1 (GPR40)-PubChem 133053953
25.00	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
25.00	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
23.08	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
23.08	Consensus	c5a1_off_ortoallo	Other Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
21.43	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
20.00	Single	6OBA	GTPL11074	6OBA-β₂-(S)-Alprenolol-GTPL11074
20.00	Consensus	beta2_off_allo	Other Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
18.18	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
16.67	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
15.38	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
15.38	Single	8IYX	YL-365	8IYX-GPR34-YL-365
8.33	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
7.69	Consensus	d1_on_allo	Other Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.14	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
6.67	Consensus	adgrf1_on_allo	Other Ligand	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
5.88	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.56	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
5.56	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.56	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
5.26	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
5.00	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.76	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.55	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
4.55	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.85	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2

PDB Summary
PDB	5XSZ
Class	A
SubFamily	Lipid
Type	Lysophospholipid (LPA)
SubType	LPA6
Species	Danio rerio
Ligand	Glyceryl Mono-oleate
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.2
Date	2017-08-16
D.O.I.	10.1038/nature23448

Net Summary
I_min	3.07
Number of Linked Nodes	267
Number of Links	302
Number of Hubs	47
Number of Links mediated by Hubs	169
Number of Communities	7
Number of Nodes involved in Communities	50
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	65287
Length Of Smallest Path	3
Average Path Length	14.5154
Length of Longest Path	30
Minimum Path Strength	1.335
Average Path Strength	6.37071
Maximum Path Strength	20.32
Minimum Path Correlation	0.7
Average Path Correlation	0.94017
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	54.1846
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.7116
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	OLC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OLC
Name	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Synonyms	1-Oleoyl-R-glycerol
Identifier	[(2R)-2,3-dihydroxypropyl] (Z)-octadec-9-enoate
Formula	C21 H40 O4
Molecular Weight	356.54
SMILES	CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](CO)O
PubChem	11451146
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	1
Total Bonds	64
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q08BG4
Sequence	>5XSZ_Chain_R D N F K Y P L Y S M V F S I V F M V G L I T N V A A M Y I F M C S L K L R N E T T T Y M M N L V V S D L L F V L T L P L R V F Y F V Q Q N W P F G S L L C K L S V S L F Y T N M Y G S I L F L T C I S V D R F L A I V Y P F R S R G L R T K R N A K I V C A A V W V L V L S G S L P T G F M L N S T N K L E N N S I S C F E W K S H L S K V V I F I E T V G F L I P L M L N V V C S A M V L Q T L R R P N T V L N K K K I L R M I I V H L F I F C F C F I P Y N V N L V F Y S L V R T N T L K G C A A E S V V R T I Y P I A L C I A V S N C C F D P I V Y Y F T S E T I Q N S A S S E D L Y F Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI

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