psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y65	10.34	Yes	Yes	3	0	7
2	L:L:?1	R:R:L115	3.66	Yes	No	0	0	5
3	L:L:?1	R:R:C119	8.4	Yes	No	3	0	6
4	L:L:?1	R:R:V122	10.51	Yes	No	0	0	6
5	L:L:?1	R:R:D123	4.79	Yes	Yes	3	0	8
6	R:R:D23	R:R:K26	8.3	No	Yes	2	4	4
7	R:R:D23	R:R:R281	7.15	No	Yes	2	4	4
8	R:R:K26	R:R:Y30	7.17	Yes	Yes	2	4	5
9	R:R:K26	R:R:R281	7.43	Yes	Yes	2	4	4
10	R:R:K26	R:R:P285	6.69	Yes	Yes	2	4	3
11	R:R:Y27	R:R:Y86	3.97	Yes	No	0	4	5
12	R:R:F87	R:R:Y27	14.44	Yes	Yes	0	5	4
13	R:R:Q90	R:R:Y27	5.64	No	Yes	0	4	4
14	R:R:C289	R:R:L29	4.76	No	No	0	4	6
15	R:R:F87	R:R:Y30	5.16	Yes	Yes	0	5	5
16	R:R:P285	R:R:Y30	5.56	Yes	Yes	2	3	5
17	R:R:L288	R:R:Y30	5.86	No	Yes	2	5	5
18	R:R:F87	R:R:S31	5.28	Yes	No	0	5	5
19	R:R:F34	R:R:V33	3.93	No	No	0	7	5
20	R:R:C289	R:R:V33	10.25	No	No	0	4	5
21	R:R:F34	R:R:L80	4.87	No	Yes	0	7	8
22	R:R:F34	R:R:R83	7.48	No	No	0	7	6
23	R:R:S35	R:R:V84	4.85	No	No	0	6	7
24	R:R:C296	R:R:V37	5.12	No	No	0	6	7
25	R:R:F38	R:R:L42	3.65	Yes	No	0	6	6
26	R:R:F38	R:R:L80	3.65	Yes	Yes	0	6	8
27	R:R:F38	R:R:P81	13	Yes	No	0	6	9
28	R:R:C296	R:R:V40	5.12	No	No	0	6	6
29	R:R:N45	R:R:V70	5.91	No	Yes	0	9	8
30	R:R:D73	R:R:N45	5.39	Yes	No	0	9	9
31	R:R:C54	R:R:Y50	4.03	No	No	0	4	3
32	R:R:F52	R:R:T63	3.89	Yes	No	0	6	8
33	R:R:F52	R:R:M66	6.22	Yes	No	1	6	8
34	R:R:F52	R:R:M67	3.73	Yes	No	0	6	5
35	R:R:F52	R:R:Y302	6.19	Yes	Yes	1	6	9
36	R:R:L56	R:R:R59	9.72	No	Yes	0	6	7
37	R:R:K140	R:R:L58	5.64	No	No	0	3	6
38	R:R:R59	R:R:T63	6.47	Yes	No	0	7	8
39	R:R:R59	R:R:S306	6.59	Yes	No	0	7	8
40	R:R:I309	R:R:R59	6.26	No	Yes	0	8	7
41	R:R:E61	R:R:N60	11.83	No	No	0	6	7
42	R:R:I309	R:R:N60	11.33	No	No	0	8	7
43	R:R:D123	R:R:E61	6.5	Yes	No	0	8	6
44	R:R:E61	R:R:R138	9.3	No	No	0	6	7
45	R:R:D123	R:R:T62	8.67	Yes	No	0	8	7
46	R:R:R124	R:R:T62	5.17	Yes	No	0	9	7
47	R:R:C119	R:R:Y65	6.72	No	Yes	3	6	7
48	R:R:D123	R:R:Y65	4.6	Yes	Yes	3	8	7
49	R:R:A143	R:R:Y65	5.34	No	Yes	0	7	7
50	R:R:V146	R:R:Y65	7.57	No	Yes	0	5	7
51	R:R:M66	R:R:Y302	11.97	No	Yes	1	8	9
52	R:R:M66	R:R:T305	4.52	No	No	0	8	6
53	R:R:F116	R:R:N68	10.87	Yes	No	1	7	9
54	R:R:C147	R:R:N68	11.02	No	No	0	7	9
55	R:R:N68	R:R:W151	6.78	No	Yes	1	9	9
56	R:R:F116	R:R:L69	8.53	Yes	No	1	7	9
57	R:R:D298	R:R:L69	9.5	Yes	No	1	9	9
58	R:R:L69	R:R:Y302	10.55	No	Yes	1	9	9
59	R:R:V70	R:R:Y302	3.79	Yes	Yes	0	8	9
60	R:R:V71	R:R:W151	3.68	No	Yes	0	6	9
61	R:R:S72	R:R:W151	3.71	No	Yes	0	8	9
62	R:R:D73	R:R:N109	6.73	Yes	No	0	9	8
63	R:R:D73	R:R:N294	8.08	Yes	Yes	1	9	9
64	R:R:C295	R:R:D73	4.67	No	Yes	0	8	9
65	R:R:D298	R:R:D73	6.65	Yes	Yes	1	9	9
66	R:R:F76	R:R:T79	3.89	Yes	No	0	7	6
67	R:R:F76	R:R:L80	3.65	Yes	Yes	0	7	8
68	R:R:F106	R:R:F76	6.43	Yes	Yes	0	6	7
69	R:R:F76	R:R:N109	13.29	Yes	No	0	7	8
70	R:R:F76	R:R:V292	5.24	Yes	No	0	7	7
71	R:R:L105	R:R:T79	4.42	No	No	0	5	6
72	R:R:F94	R:R:L82	8.53	Yes	No	0	7	5
73	R:R:F87	R:R:R83	4.28	Yes	No	0	5	6
74	R:R:F106	R:R:R83	6.41	Yes	No	0	6	6
75	R:R:F85	R:R:Q89	9.37	No	No	0	4	3
76	R:R:W92	R:R:Y86	4.82	Yes	No	0	8	5
77	R:R:N91	R:R:Q89	9.24	No	No	0	4	3
78	R:R:N91	R:R:P93	6.52	No	No	0	4	3
79	R:R:F94	R:R:W92	21.05	Yes	Yes	0	7	8
80	R:R:C99	R:R:W92	3.92	No	Yes	5	9	8
81	R:R:I176	R:R:W92	4.7	No	Yes	0	3	8
82	R:R:C178	R:R:W92	19.59	No	Yes	5	9	8
83	R:R:F94	R:R:P93	7.22	Yes	No	0	7	3
84	R:R:F94	R:R:L98	6.09	Yes	No	0	7	5
85	R:R:S96	R:R:T168	7.99	No	No	0	3	2
86	R:R:C178	R:R:C99	7.28	No	No	5	9	9
87	R:R:K100	R:R:S104	10.71	Yes	No	6	7	4
88	R:R:K100	R:R:L159	9.87	Yes	Yes	6	7	4
89	R:R:F163	R:R:K100	34.74	No	Yes	0	5	7
90	R:R:N166	R:R:V103	8.87	No	No	0	4	5
91	R:R:L159	R:R:S104	6.01	Yes	No	6	4	4
92	R:R:L105	R:R:T108	4.42	No	Yes	0	5	5
93	R:R:F106	R:R:Y107	15.47	Yes	No	0	6	5
94	R:R:F106	R:R:Y256	5.16	Yes	Yes	2	6	6
95	R:R:F106	R:R:L288	4.87	Yes	No	2	6	5
96	R:R:T108	R:R:V154	4.76	Yes	No	0	5	7
97	R:R:L155	R:R:T108	4.42	No	Yes	0	3	5
98	R:R:S158	R:R:T108	6.4	No	Yes	0	7	5
99	R:R:N109	R:R:S113	5.96	No	No	0	8	9
100	R:R:M110	R:R:Y111	4.79	No	No	0	7	6
101	R:R:M110	R:R:Y256	8.38	No	Yes	0	7	6
102	R:R:E199	R:R:Y111	11.22	Yes	No	0	5	6
103	R:R:N294	R:R:S113	7.45	Yes	No	0	9	9
104	R:R:F249	R:R:I114	3.77	Yes	No	1	9	7
105	R:R:F253	R:R:I114	15.07	Yes	No	1	8	7
106	R:R:L115	R:R:V150	5.96	No	No	0	5	7
107	R:R:F116	R:R:V150	13.11	Yes	No	0	7	7
108	R:R:F116	R:R:W151	6.01	Yes	Yes	1	7	9
109	R:R:F249	R:R:L117	4.87	Yes	No	0	9	8
110	R:R:D298	R:R:L117	4.07	Yes	No	0	9	8
111	R:R:P206	R:R:T118	6.99	No	No	0	9	8
112	R:R:N210	R:R:T118	10.24	Yes	No	0	7	8
113	R:R:N210	R:R:S121	7.45	Yes	No	1	7	9
114	R:R:H245	R:R:S121	9.76	No	No	1	7	9
115	R:R:A127	R:R:R124	5.53	No	Yes	0	8	9
116	R:R:M241	R:R:R124	4.96	Yes	Yes	4	7	9
117	R:R:R124	R:R:T308	9.06	Yes	No	4	9	5
118	R:R:Q310	R:R:R124	8.18	No	Yes	0	8	9
119	R:R:F125	R:R:L126	4.87	Yes	No	0	8	5
120	R:R:F125	R:R:V129	6.55	Yes	No	0	8	7
121	R:R:C213	R:R:F125	9.78	No	Yes	0	6	8
122	R:R:F125	R:R:M216	8.71	Yes	No	0	8	4
123	R:R:L126	R:R:S134	9.01	No	No	0	5	6
124	R:R:A127	R:R:R138	5.53	No	No	0	8	7
125	R:R:I128	R:R:I238	7.36	No	No	0	8	8
126	R:R:V129	R:R:Y130	7.57	No	No	0	7	6
127	R:R:T220	R:R:V129	6.35	No	No	0	5	7
128	R:R:R133	R:R:Y130	11.32	Yes	No	0	4	6
129	R:R:F132	R:R:P131	10.11	No	No	0	6	8
130	R:R:R133	R:R:S134	6.59	Yes	No	0	4	6
131	R:R:L137	R:R:R133	3.64	No	Yes	0	4	4
132	R:R:R138	R:R:S134	7.91	No	No	0	7	6
133	R:R:N142	R:R:T139	5.85	No	No	0	4	6
134	R:R:I145	R:R:R141	10.02	No	No	0	3	4
135	R:R:L155	R:R:W151	5.69	No	Yes	0	3	9
136	R:R:G162	R:R:T161	3.64	No	No	0	3	4
137	R:R:E172	R:R:N169	9.2	No	No	0	2	3
138	R:R:K170	R:R:S177	15.3	No	No	0	1	3
139	R:R:L171	R:R:S175	6.01	No	No	0	3	2
140	R:R:E172	R:R:I176	5.47	No	No	0	2	3
141	R:R:E186	R:R:K188	12.15	No	No	7	2	2
142	R:R:E186	R:R:R267	10.47	No	No	7	2	4
143	R:R:K188	R:R:R267	8.66	No	No	7	2	4
144	R:R:S192	R:R:S264	4.89	No	No	0	3	5
145	R:R:I196	R:R:S264	4.64	No	No	0	4	5
146	R:R:F197	R:R:V201	3.93	No	No	0	3	4
147	R:R:E199	R:R:N257	13.15	Yes	No	0	5	7
148	R:R:E199	R:R:L260	3.98	Yes	No	0	5	6
149	R:R:F203	R:R:I254	3.77	No	Yes	0	8	6
150	R:R:F203	R:R:N257	24.17	No	No	0	8	7
151	R:R:I205	R:R:P206	5.08	No	No	0	5	9
152	R:R:F249	R:R:L207	6.09	Yes	No	0	9	7
153	R:R:I254	R:R:L207	4.28	Yes	No	0	6	7
154	R:R:H245	R:R:N210	7.65	No	Yes	1	7	7
155	R:R:F249	R:R:N210	9.67	Yes	Yes	1	9	7
156	R:R:I242	R:R:S214	6.19	Yes	No	0	7	9
157	R:R:L246	R:R:S214	7.51	No	No	0	7	9
158	R:R:I242	R:R:V217	4.61	Yes	No	0	7	8
159	R:R:I242	R:R:L218	7.14	Yes	No	0	7	4
160	R:R:I238	R:R:L221	5.71	No	No	0	8	8
161	R:R:P224	R:R:R223	5.76	No	No	0	6	5
162	R:R:K235	R:R:T226	6.01	No	Yes	0	7	2
163	R:R:K237	R:R:N234	16.79	No	No	0	7	5
164	R:R:K236	R:R:L239	4.23	No	No	0	5	6
165	R:R:K236	R:R:R240	23.51	No	No	0	5	5
166	R:R:E307	R:R:K237	12.15	No	No	0	6	7
167	R:R:I243	R:R:L239	4.28	No	No	0	5	6
168	R:R:M241	R:R:T305	6.02	Yes	No	0	7	6
169	R:R:M241	R:R:T308	10.54	Yes	No	4	7	5
170	R:R:F304	R:R:V244	6.55	No	No	0	7	5
171	R:R:F297	R:R:I248	3.77	Yes	Yes	0	6	6
172	R:R:I248	R:R:V301	4.61	Yes	No	0	6	7
173	R:R:F249	R:R:F253	5.36	Yes	Yes	1	9	8
174	R:R:C250	R:R:I254	4.91	No	Yes	0	5	6
175	R:R:F251	R:R:I290	8.79	No	No	0	6	7
176	R:R:C252	R:R:F253	4.19	No	Yes	0	7	8
177	R:R:C252	R:R:F297	4.19	No	Yes	0	7	6
178	R:R:F253	R:R:N294	6.04	Yes	Yes	1	8	9
179	R:R:N257	R:R:Y256	5.81	No	Yes	0	7	6
180	R:R:L260	R:R:Y256	9.38	No	Yes	0	6	6
181	R:R:Y256	R:R:Y284	10.92	Yes	No	2	6	5
182	R:R:L288	R:R:Y256	4.69	No	Yes	2	5	6
183	R:R:I283	R:R:N259	11.33	No	No	0	5	5
184	R:R:V280	R:R:Y263	5.05	No	No	0	5	4
185	R:R:R281	R:R:Y263	5.14	Yes	No	0	4	4
186	R:R:L265	R:R:N269	4.12	Yes	No	0	4	4
187	R:R:T270	R:R:V266	4.76	No	No	0	1	3
188	R:R:N269	R:R:T268	5.85	No	No	0	4	2
189	R:R:R281	R:R:Y284	5.14	Yes	No	2	4	5
190	R:R:P285	R:R:R281	10.09	Yes	Yes	2	3	4
191	R:R:P285	R:R:Y284	4.17	Yes	No	2	3	5
192	R:R:F297	R:R:S293	3.96	Yes	No	0	6	4
193	R:R:D298	R:R:N294	12.12	Yes	Yes	1	9	9
194	R:R:D298	R:R:Y302	10.34	Yes	Yes	1	9	9
195	R:R:F304	R:R:Y303	12.38	No	No	0	7	6
196	R:R:E307	R:R:Y303	12.35	No	No	0	6	6
197	R:R:L318	R:R:Y319	11.72	No	No	0	5	2
198	R:R:I198	R:R:Y111	3.63	No	No	0	5	6
199	R:R:P299	R:R:T44	3.5	No	No	0	9	7
200	R:R:G162	R:R:K100	3.49	No	Yes	0	3	7
201	R:R:C295	R:R:V77	3.42	No	No	0	8	5
202	R:R:I254	R:R:P255	3.39	Yes	No	0	6	9
203	R:R:A143	R:R:T64	3.36	No	No	0	7	6
204	R:R:N45	R:R:P299	3.26	No	No	0	9	9
205	R:R:F251	R:R:F297	3.22	No	Yes	0	6	6
206	R:R:F132	R:R:R133	3.21	No	Yes	0	6	4
207	R:R:F304	R:R:R240	3.21	No	No	0	7	5
208	R:R:V266	R:R:V280	3.21	No	No	0	3	5
209	R:R:I128	R:R:V217	3.07	No	No	0	8	8
210	R:R:I248	R:R:V244	3.07	Yes	No	0	6	5
211	R:R:I283	R:R:V279	3.07	No	No	0	5	2
212	R:R:M49	R:R:V70	3.04	No	Yes	0	7	8
213	R:R:I120	R:R:T305	3.04	No	No	0	8	6
214	R:R:I196	R:R:T200	3.04	No	No	0	4	4
215	R:R:G136	R:R:R135	3	No	No	0	4	5
216	R:R:L80	R:R:V37	2.98	Yes	No	0	8	7
217	R:R:L42	R:R:V46	2.98	No	No	0	6	3
218	R:R:L74	R:R:V70	2.98	No	Yes	0	7	8
219	R:R:L75	R:R:V71	2.98	No	No	0	7	6
220	R:R:L209	R:R:V122	2.98	No	No	0	7	6
221	R:R:L191	R:R:V195	2.98	No	No	0	4	5
222	R:R:L260	R:R:V195	2.98	No	No	0	6	5
223	R:R:N259	R:R:V280	2.96	No	No	0	5	5
224	R:R:L233	R:R:T226	2.95	No	Yes	0	4	2
225	R:R:I248	R:R:I300	2.94	Yes	No	0	6	7
226	R:R:I242	R:R:M241	2.92	Yes	Yes	0	7	7
227	R:R:E199	R:R:V261	2.85	Yes	No	0	5	5
228	R:R:L165	R:R:M164	2.83	No	No	0	5	4
229	R:R:K100	R:R:L101	2.82	Yes	No	0	7	5
230	R:R:K235	R:R:L221	2.82	No	No	0	7	8
231	R:R:P28	R:R:Y27	2.78	No	Yes	0	3	4
232	R:R:L101	R:R:L105	2.77	No	No	0	5	5
233	R:R:L155	R:R:L159	2.77	No	Yes	0	3	4
234	R:R:A291	R:R:Y256	2.67	No	Yes	0	8	6
235	R:R:R267	R:R:T268	2.59	No	No	0	4	2
236	R:R:V103	R:R:Y107	2.52	No	No	0	5	5
237	R:R:F247	R:R:I243	2.51	No	No	0	5	5
238	R:R:F38	R:R:M39	2.49	Yes	No	0	6	5
239	R:R:F179	R:R:K170	2.48	No	No	0	4	1
240	R:R:S102	R:R:W92	2.47	No	Yes	0	5	8
241	R:R:F25	R:R:L29	2.44	No	No	0	3	6
242	R:R:F262	R:R:L265	2.44	No	Yes	0	4	4
243	R:R:T168	R:R:W92	2.43	No	Yes	0	2	8
244	R:R:C296	R:R:G41	1.96	No	No	0	6	8
245	R:R:A276	R:R:G273	1.95	No	No	0	1	5
246	R:R:A287	R:R:P255	1.87	No	No	0	6	9
247	R:R:G112	R:R:V150	1.84	No	No	0	7	7
248	R:R:G112	R:R:V154	1.84	No	No	0	7	7
249	R:R:A276	R:R:V266	1.7	No	No	0	1	3
250	R:R:L159	R:R:P160	1.64	Yes	No	0	4	8
251	R:R:C54	R:R:M53	1.62	No	No	0	4	2
252	R:R:S156	R:R:V152	1.62	No	No	0	4	4
253	R:R:A276	R:R:K272	1.61	No	No	0	1	1
254	R:R:V84	R:R:V88	1.6	No	No	0	7	4
255	R:R:S278	R:R:T282	1.6	No	No	0	3	2
256	R:R:T226	R:R:V227	1.59	Yes	No	0	2	3
257	R:R:I36	R:R:V40	1.54	No	No	0	5	6
258	R:R:I254	R:R:V258	1.54	Yes	No	0	6	5
259	R:R:M208	R:R:V212	1.52	No	No	0	3	4
260	R:R:M216	R:R:V212	1.52	No	No	0	4	4
261	R:R:I283	R:R:T282	1.52	No	No	0	5	2
262	R:R:F94	R:R:G95	1.51	Yes	No	0	7	8
263	R:R:L56	R:R:S55	1.5	No	No	0	6	5
264	R:R:K144	R:R:T64	1.5	No	No	0	4	6
265	R:R:L171	R:R:S177	1.5	No	No	0	3	3
266	R:R:L265	R:R:S264	1.5	Yes	No	0	4	5
267	R:R:L78	R:R:V77	1.49	No	No	0	5	5
268	R:R:N174	R:R:S175	1.49	No	No	0	6	2
269	R:R:L265	R:R:V261	1.49	Yes	No	0	4	5
270	R:R:L58	R:R:T64	1.47	No	No	0	6	6
271	R:R:L165	R:R:T161	1.47	No	No	0	5	4
272	R:R:I286	R:R:I290	1.47	No	No	0	5	7
273	R:R:I36	R:R:M32	1.46	No	No	0	5	5
274	R:R:I43	R:R:M39	1.46	No	No	0	5	5
275	R:R:M49	R:R:M53	1.44	No	No	0	7	2
276	R:R:M53	R:R:M67	1.44	No	No	0	2	5
277	R:R:E277	R:R:S278	1.44	No	No	0	4	3
278	R:R:E316	R:R:S315	1.44	No	No	0	3	6
279	R:R:Q89	R:R:V88	1.43	No	No	0	3	4
280	R:R:A48	R:R:F52	1.39	No	Yes	0	8	6
281	R:R:L204	R:R:L207	1.38	No	No	0	5	7
282	R:R:L56	R:R:N311	1.37	No	No	0	6	5
283	R:R:R141	R:R:T139	1.29	No	No	0	4	6
284	R:R:H190	R:R:L191	1.29	No	No	0	3	4
285	R:R:R223	R:R:T226	1.29	No	Yes	0	5	2
286	R:R:S177	R:R:Y86	1.27	No	No	0	3	5
287	R:R:F197	R:R:I198	1.26	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.54	5	3	0
2	R:R:K26	7.3975	4	2	4
3	R:R:Y27	6.7075	4	0	4
4	R:R:Y30	5.9375	4	2	5
5	R:R:F38	5.6975	4	0	6
6	R:R:F52	4.284	5	1	6
7	R:R:R59	7.26	4	0	7
8	R:R:Y65	6.914	5	3	7
9	R:R:V70	3.93	4	0	8
10	R:R:D73	6.304	5	1	9
11	R:R:F76	6.5	5	0	7
12	R:R:L80	3.7875	4	0	8
13	R:R:F87	7.29	4	0	5
14	R:R:W92	8.42571	7	5	8
15	R:R:F94	8.88	5	0	7
16	R:R:K100	12.326	5	6	7
17	R:R:F106	7.668	5	2	6
18	R:R:T108	5	4	0	5
19	R:R:F116	9.63	4	1	7
20	R:R:D123	6.14	4	3	8
21	R:R:R124	6.58	5	4	9
22	R:R:F125	7.4775	4	0	8
23	R:R:R133	6.19	4	0	4
24	R:R:W151	5.174	5	1	9
25	R:R:L159	5.0725	4	6	4
26	R:R:E199	7.8	4	0	5
27	R:R:N210	8.7525	4	1	7
28	R:R:T226	2.96	4	0	2
29	R:R:M241	6.11	4	4	7
30	R:R:I242	5.215	4	0	7
31	R:R:I248	3.5975	4	0	6
32	R:R:F249	5.952	5	1	9
33	R:R:F253	7.665	4	1	8
34	R:R:I254	3.578	5	0	6
35	R:R:Y256	6.71571	7	2	6
36	R:R:L265	2.3875	4	0	4
37	R:R:R281	6.99	5	2	4
38	R:R:P285	6.6275	4	2	3
39	R:R:N294	8.4225	4	1	9
40	R:R:F297	3.785	4	0	6
41	R:R:D298	8.536	5	1	9
42	R:R:Y302	8.568	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L115	29.0779	3.66	Yes	No	0	0	5
2	R:R:L115	R:R:V150	30.6965	5.96	No	No	0	5	7
3	R:R:F116	R:R:V150	21.7998	13.11	Yes	No	0	7	7
4	R:R:F116	R:R:L69	30.3203	8.53	Yes	No	1	7	9
5	R:R:D298	R:R:L69	23.9599	9.5	Yes	No	1	9	9
6	R:R:D298	R:R:D73	55.8475	6.65	Yes	Yes	1	9	9
7	R:R:D73	R:R:N109	77.8525	6.73	Yes	No	0	9	8
8	R:R:F76	R:R:N109	93.8903	13.29	Yes	No	0	7	8
9	R:R:F106	R:R:F76	100	6.43	Yes	Yes	0	6	7
10	R:R:F106	R:R:Y256	65.9011	5.16	Yes	Yes	2	6	6
11	R:R:Y256	R:R:Y284	27.0888	10.92	Yes	No	2	6	5
12	R:R:R281	R:R:Y284	23.8174	5.14	Yes	No	2	4	5
13	R:R:G112	R:R:V150	12.8063	1.84	No	No	0	7	7
14	R:R:G112	R:R:V154	12.7379	1.84	No	No	0	7	7
15	R:R:T108	R:R:V154	12.8063	4.76	Yes	No	0	5	7
16	R:R:L105	R:R:T108	20.8766	4.42	No	Yes	0	5	5
17	R:R:L105	R:R:T79	30.8446	4.42	No	No	0	5	6
18	R:R:F76	R:R:T79	31.9332	3.89	Yes	No	0	7	6
19	R:R:L288	R:R:Y30	14.9835	5.86	No	Yes	2	5	5
20	R:R:F106	R:R:R83	49.8518	6.41	Yes	No	0	6	6
21	R:R:F87	R:R:R83	51.345	4.28	Yes	No	0	5	6
22	R:R:F87	R:R:Y27	62.0198	14.44	Yes	Yes	0	5	4
23	R:R:Y27	R:R:Y86	56.2635	3.97	Yes	No	0	4	5
24	R:R:F76	R:R:L80	26.0857	3.65	Yes	Yes	0	7	8
25	R:R:W92	R:R:Y86	42.4655	4.82	Yes	No	0	8	5
26	R:R:F94	R:R:W92	23.9428	21.05	Yes	Yes	0	7	8
27	R:R:F94	R:R:P93	15.3938	7.22	Yes	No	0	7	3
28	R:R:N91	R:R:P93	13.2281	6.52	No	No	0	4	3
29	R:R:N91	R:R:Q89	11.051	9.24	No	No	0	4	3
30	R:R:L80	R:R:V37	11.1079	2.98	Yes	No	0	8	7
31	R:R:F38	R:R:L80	11.1079	3.65	Yes	Yes	0	6	8
32	R:R:F52	R:R:Y302	15.8327	6.19	Yes	Yes	1	6	9
33	R:R:R59	R:R:T63	11.5411	6.47	Yes	No	0	7	8
34	R:R:M66	R:R:Y302	45.7483	11.97	No	Yes	1	8	9
35	R:R:M241	R:R:R124	28.0349	4.96	Yes	Yes	4	7	9
36	R:R:M241	R:R:T305	45.224	6.02	Yes	No	0	7	6
37	R:R:M66	R:R:T305	47.2187	4.52	No	No	0	8	6
38	L:L:?1	R:R:Y65	13.7182	10.34	Yes	Yes	3	0	7
39	R:R:A143	R:R:Y65	11.6779	5.34	No	Yes	0	7	7
40	R:R:F116	R:R:W151	11.5297	6.01	Yes	Yes	1	7	9
41	R:R:D298	R:R:N294	13.627	12.12	Yes	Yes	1	9	9
42	R:R:L155	R:R:W151	13.0115	5.69	No	Yes	0	3	9
43	R:R:N294	R:R:S113	16.357	7.45	Yes	No	0	9	9
44	R:R:N257	R:R:Y256	32.4689	5.81	No	Yes	0	7	6
45	R:R:E199	R:R:N257	28.1489	13.15	Yes	No	0	5	7
46	R:R:D298	R:R:L117	19.0471	4.07	Yes	No	0	9	8
47	R:R:F249	R:R:L117	18.386	4.87	Yes	No	0	9	8
48	R:R:F249	R:R:L207	23.8345	6.09	Yes	No	0	9	7
49	R:R:I254	R:R:L207	23.219	4.28	Yes	No	0	6	7
50	R:R:F203	R:R:I254	23.5609	3.77	No	Yes	0	8	6
51	R:R:F203	R:R:N257	23.7205	24.17	No	No	0	8	7
52	R:R:L260	R:R:Y256	25.4303	9.38	No	Yes	0	6	6
53	R:R:E199	R:R:L260	19.275	3.98	Yes	No	0	5	6
54	R:R:F253	R:R:N294	44.8991	6.04	Yes	Yes	1	8	9
55	R:R:F249	R:R:N210	15.4166	9.67	Yes	Yes	1	9	7
56	R:R:A127	R:R:R138	21.4864	5.53	No	No	0	8	7
57	R:R:A127	R:R:R124	22.6661	5.53	No	Yes	0	8	9
58	R:R:R138	R:R:S134	24.7977	7.91	No	No	0	7	6
59	R:R:L126	R:R:S134	12.5841	9.01	No	No	0	5	6
60	R:R:F125	R:R:L126	11.0453	4.87	Yes	No	0	8	5
61	R:R:R133	R:R:S134	11.0282	6.59	Yes	No	0	4	6
62	R:R:I242	R:R:M241	22.0164	2.92	Yes	Yes	0	7	7
63	R:R:I242	R:R:V217	15.9524	4.61	Yes	No	0	7	8
64	R:R:I128	R:R:V217	14.4078	3.07	No	No	0	8	8
65	R:R:I128	R:R:I238	12.8519	7.36	No	No	0	8	8
66	R:R:S177	R:R:Y86	13.2281	1.27	No	No	0	3	5
67	R:R:E199	R:R:V261	41.6448	2.85	Yes	No	0	5	5
68	R:R:L265	R:R:V261	38.2366	1.49	Yes	No	0	4	5
69	R:R:L265	R:R:N269	17.5482	4.12	Yes	No	0	4	4
70	R:R:N269	R:R:T268	14.0602	5.85	No	No	0	4	2
71	R:R:R267	R:R:T268	10.5608	2.59	No	No	0	4	2
72	R:R:L265	R:R:S264	14.0602	1.5	Yes	No	0	4	5
73	R:R:I238	R:R:L221	11.2846	5.71	No	No	0	8	8
74	R:R:C252	R:R:F253	42.7391	4.19	No	Yes	0	7	8
75	R:R:C252	R:R:F297	40.7101	4.19	No	Yes	0	7	6
76	R:R:F297	R:R:I248	30.3944	3.77	Yes	Yes	0	6	6
77	R:R:I248	R:R:V244	24.0682	3.07	Yes	No	0	6	5
78	R:R:F304	R:R:V244	21.9366	6.55	No	No	0	7	5
79	R:R:F304	R:R:R240	11.1079	3.21	No	No	0	7	5
80	R:R:R281	R:R:Y263	26.667	5.14	Yes	No	0	4	4
81	R:R:V280	R:R:Y263	24.6837	5.05	No	No	0	5	4
82	R:R:N259	R:R:V280	12.5442	2.96	No	No	0	5	5
83	R:R:I283	R:R:N259	10.481	11.33	No	No	0	5	5
84	R:R:V266	R:R:V280	10.481	3.21	No	No	0	3	5
85	R:R:L101	R:R:L105	10.3214	2.77	No	No	0	5	5
86	R:R:F52	R:R:T63	12.7094	3.89	Yes	No	0	6	8
87	R:R:F87	R:R:Y30	17.2233	5.16	Yes	Yes	0	5	5
88	R:R:D298	R:R:Y302	56.406	10.34	Yes	Yes	1	9	9
89	R:R:D73	R:R:N294	17.9243	8.08	Yes	Yes	1	9	9
90	R:R:N109	R:R:S113	16.4026	5.96	No	No	0	8	9
91	R:R:F249	R:R:F253	13.6213	5.36	Yes	Yes	1	9	8
92	R:R:L288	R:R:Y256	10.6463	4.69	No	Yes	2	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y65	10.34	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:L115	3.66	3	Yes	No	0	5	0	1
L:L:?1	R:R:C119	8.4	3	Yes	No	0	6	0	1
L:L:?1	R:R:V122	10.51	3	Yes	No	0	6	0	1
L:L:?1	R:R:D123	4.79	3	Yes	Yes	0	8	0	1
R:R:D123	R:R:E61	6.5	3	Yes	No	8	6	1	2
R:R:D123	R:R:T62	8.67	3	Yes	No	8	7	1	2
R:R:C119	R:R:Y65	6.72	3	No	Yes	6	7	1	1
R:R:D123	R:R:Y65	4.6	3	Yes	Yes	8	7	1	1
R:R:A143	R:R:Y65	5.34	0	No	Yes	7	7	2	1
R:R:V146	R:R:Y65	7.57	0	No	Yes	5	7	2	1
R:R:L115	R:R:V150	5.96	0	No	No	5	7	1	2
R:R:L209	R:R:V122	2.98	0	No	No	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
40.00	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/β1/γ2
40.00	Single	8Y72	BMS-986122	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
40.00	Single	9JCQ	LPC	9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
30.77	Single	9IYB	A1D5Q	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
30.00	Single	8K9L	BMS-986122	8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
30.00	Single	9JCP	LPC	9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00	Single	9K1C	DHA	9K1C-FFA1-DHA-Gi1/β1/γ2
28.57	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/β1/γ2
28.57	Single	8XXV	A1D5Q	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
27.78	Single	5KW2	PubChem 133053953	5KW2-FFA1-PubChem 133053953
27.27	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
25.00	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/β1/γ2
23.53	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
23.08	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
21.43	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/β1/γ2
21.43	Single	9CM7	AZ-1729	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
20.00	Single	6OBA	GTPL11074	6OBA-β₂-S-Alprenolol-GTPL11074
20.00	Single	8XXU	A1D5Q	8XXU-DP₂-A1D5Q-Gi1/β1/γ2
18.18	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
18.18	Single	9CM3	Compound 187	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
15.38	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
15.38	Single	8IYX	YL-365	8IYX-GPR34-YL-365
13.33	Single	8YYX	Leukotriene e4	8YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
10.00	Single	9NS9	Compound 187	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
8.33	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.33	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.14	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
5.88	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.88	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
5.56	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
5.56	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
5.56	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
5.26	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.26	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
5.00	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.00	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.70	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.57	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2

PDB Summary
PDB	5XSZ
Class	A
SubFamily	Lipid
Type	Lysophospholipid
SubType	LPA6
Species	Danio Rerio
Ligand	Glyceryl-mono-oleate
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.2
Date	2017-08-16
D.O.I.	doi.org/10.1038/nature23448

Net Summary
I_min	3.64
Number of Linked Nodes	259
Number of Links	287
Number of Hubs	42
Number of Links mediated by Hubs	160
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	44988
Length Of Smallest Path	3
Average Path Length	13.0188
Length of Longest Path	30
Minimum Path Strength	1.385
Average Path Strength	6.44883
Maximum Path Strength	22.725
Minimum Path Correlation	0.7
Average Path Correlation	0.938807
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	59.2472
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.2202
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • immune response • immune system process • adaptive immune response • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • cell periphery • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	OLC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OLC
Name	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Synonyms	1-Oleoyl-R-glycerol
Identifier
Formula	C21 H40 O4
Molecular Weight	356.54
SMILES
PubChem	11451146
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	1
Total Bonds	64
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q08BG4
Sequence	>5XSZ_Chain_R D N F K Y P L Y S M V F S I V F M V G L I T N V A A M Y I F M C S L K L R N E T T T Y M M N L V V S D L L F V L T L P L R V F Y F V Q Q N W P F G S L L C K L S V S L F Y T N M Y G S I L F L T C I S V D R F L A I V Y P F R S R G L R T K R N A K I V C A A V W V L V L S G S L P T G F M L N S T N K L E N N S I S C F E W K S H L S K V V I F I E T V G F L I P L M L N V V C S A M V L Q T L R R P N T V L N K K K I L R M I I V H L F I F C F C F I P Y N V N L V F Y S L V R T N T L K G C A A E S V V R T I Y P I A L C I A V S N C C F D P I V Y Y F T S E T I Q N S A S S E D L Y F Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9ITB	A	Lipid	Lysophospholipid	LPA₆	Homo sapiens	LPA	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2025-01-15	doi.org/10.1073/pnas.2415426122
	9ITB (No Gprot)	A	Lipid	Lysophospholipid	LPA₆	Homo sapiens	LPA	-		2.89	2025-01-15	doi.org/10.1073/pnas.2415426122
	9ITE	A	Lipid	Lysophospholipid	LPA₆	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.06	2025-01-15	doi.org/10.1073/pnas.2415426122
	9ITE (No Gprot)	A	Lipid	Lysophospholipid	LPA₆	Homo sapiens	LPA	-		3.06	2025-01-15	doi.org/10.1073/pnas.2415426122

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