Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 5.958571410
2R:R:Y20 5.038505
3R:R:F42 4.1775447
4R:R:L46 2.3025406
5R:R:Y55 3.83507
6R:R:Y76 5.145425
7R:R:W82 6.03833628
8R:R:K90 4.0925437
9R:R:F96 5.2375406
10R:R:T98 4.245405
11R:R:N99 3.435408
12R:R:Y101 4.1825417
13R:R:F115 6.246508
14R:R:R128 5.305407
15R:R:S156 4.3025434
16R:R:E170 6.07424
17R:R:F172 5.295415
18R:R:Y180 4.46401
19R:R:L181 6.6375414
20R:R:V191 3.3525414
21R:R:I231 3.955407
22R:R:H234 11.15467
23R:R:V243 3.3875406
24R:R:Y245 3.92833607
25R:R:Y252 5.714514
26R:R:R256 7.245413
27R:R:V269 2.5475405
28R:R:Y273 6.58415
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y252 17.14395.87YesYes104
2L:L:?1 R:R:Y97 14.766416.78YesNo005
3R:R:Y245 R:R:Y97 24.91452.98YesNo075
4R:R:L277 R:R:Y245 19.62028.21NoYes067
5R:R:L277 R:R:Y20 17.97953.52NoYes065
6L:L:?1 R:R:Y273 18.8915.87YesYes105
7R:R:Y245 R:R:Y273 15.61723.97YesYes075
8R:R:P274 R:R:Y273 11.31035.56NoYes055
9R:R:F77 R:R:Y20 30.641914.44NoYes045
10R:R:F96 R:R:Y97 19.99243.09YesNo065
11R:R:F96 R:R:V281 27.0493.93YesNo067
12R:R:F24 R:R:V281 25.75777.87NoNo087
13R:R:F77 R:R:Y76 25.60586.19NoYes245
14R:R:W82 R:R:Y76 27.4443.86YesYes285
15R:R:F84 R:R:W82 19.559414.03NoYes278
16R:R:F84 R:R:P83 17.21991.44NoNo072
17R:R:F75 R:R:P83 12.37371.44NoNo042
18L:L:?1 R:R:L181 32.22182.97YesYes104
19R:R:L181 R:R:Y180 31.0524.69YesYes041
20R:R:V154 R:R:Y180 22.42315.05NoYes051
21R:R:S156 R:R:V154 13.23213.23YesNo345
22L:L:?1 R:R:S148 60.69129.67YesNo007
23R:R:S148 R:R:T98 59.80253.2NoYes075
24R:R:N99 R:R:T98 58.64794.39YesYes085
25R:R:N99 R:R:S62 1002.98YesNo088
26R:R:S62 R:R:W141 99.74933.71NoNo089
27R:R:N58 R:R:W141 99.48354.52NoNo099
28R:R:C137 R:R:N58 96.10337.87NoNo579
29R:R:C137 R:R:Y55 97.92632.69NoYes077
30R:R:I110 R:R:Y55 85.6214.84NoYes097
31R:R:I110 R:R:Y291 85.02856.04NoNo099
32R:R:L107 R:R:Y291 55.10824.69NoNo089
33R:R:L107 R:R:L59 53.93852.77NoNo089
34R:R:D287 R:R:L59 51.4474.07NoNo099
35R:R:D287 R:R:D63 24.74746.65NoNo099
36R:R:D63 R:R:N35 23.19035.39NoNo099
37R:R:N35 R:R:P288 15.17664.89NoNo099
38R:R:P288 R:R:S34 13.52833.56NoNo097
39R:R:G31 R:R:S34 11.86481.86NoNo087
40R:R:A133 R:R:Y55 26.06914NoYes087
41R:R:A133 R:R:T54 24.52723.36NoNo087
42R:R:K130 R:R:T54 18.20743NoNo037
43R:R:K130 R:R:R49 14.93354.95NoNo036
44R:R:L46 R:R:R49 13.52072.43YesNo066
45R:R:F66 R:R:F96 44.23859.65NoYes076
46R:R:D287 R:R:N283 29.52539.42NoNo099
47R:R:F242 R:R:N283 20.22796.04NoNo099
48R:R:F242 R:R:I104 18.625113.82NoNo098
49R:R:F238 R:R:I104 10.38362.51NoNo098
50R:R:H234 R:R:Y291 46.555328.31YesNo079
51R:R:H234 R:R:R114 37.0685.64YesNo679
52R:R:I231 R:R:R114 36.17932.51YesNo079
53R:R:I231 R:R:V207 24.48163.07YesNo078
54R:R:F115 R:R:V207 21.59512.62YesNo088
55R:R:L249 R:R:Y245 18.79233.52NoYes057
56R:R:L249 R:R:V185 16.76412.98NoNo055
57R:R:S253 R:R:V185 12.66244.85NoNo055
58L:L:?1 R:R:I188 18.70115.11YesNo105
59R:R:E189 R:R:I188 19.37714.1NoNo065
60R:R:E189 R:R:N246 17.007211.83NoNo068
61R:R:F193 R:R:N246 14.622121.75NoNo088
62R:R:I231 R:R:L208 10.38367.14YesNo074
63R:R:V269 R:R:Y252 17.72882.52YesYes054
64R:R:F66 R:R:N99 44.01063.62NoYes078
65R:R:F24 R:R:Y20 23.65363.09NoYes085
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y97 16.78 1 Yes No 0 5 0 1
L:L:?1 R:R:Y101 4.19 1 Yes Yes 0 7 0 1
L:L:?1 R:R:S148 9.67 1 Yes No 0 7 0 1
L:L:?1 R:R:F172 5.23 1 Yes Yes 0 5 0 1
L:L:?1 R:R:W177 10.59 1 Yes No 0 1 0 1
L:L:?1 R:R:L181 2.97 1 Yes Yes 0 4 0 1
L:L:?1 R:R:F187 5.23 1 Yes No 0 3 0 1
L:L:?1 R:R:I188 5.11 1 Yes No 0 5 0 1
L:L:?1 R:R:V191 4.26 1 Yes Yes 0 4 0 1
L:L:?1 R:R:Y252 5.87 1 Yes Yes 0 4 0 1
L:L:?1 R:R:R256 4.35 1 Yes Yes 0 3 0 1
L:L:?1 R:R:Y273 5.87 1 Yes Yes 0 5 0 1
R:R:M94 R:R:S148 3.07 0 No No 6 7 2 1
R:R:F96 R:R:Y97 3.09 0 Yes No 6 5 2 1
R:R:Y245 R:R:Y97 2.98 0 Yes No 7 5 2 1
R:R:S148 R:R:T98 3.2 0 No Yes 7 5 1 2
R:R:I188 R:R:Y101 7.25 1 No Yes 5 7 1 1
R:R:G192 R:R:Y101 2.9 0 No Yes 5 7 2 1
R:R:F169 R:R:F172 6.43 0 No Yes 4 5 2 1
R:R:F172 R:R:P173 4.33 1 Yes No 5 4 1 2
R:R:F172 R:R:T176 5.19 1 Yes No 5 2 1 2
R:R:P173 R:R:T176 3.5 1 No No 4 2 2 2
R:R:L181 R:R:T176 2.95 1 Yes No 4 2 1 2
R:R:L181 R:R:W177 15.94 1 Yes No 4 1 1 1
R:R:R256 R:R:W177 11 1 Yes No 3 1 1 1
R:R:L181 R:R:Y180 4.69 1 Yes Yes 4 1 1 2
R:R:F187 R:R:V191 3.93 1 No Yes 3 4 1 1
R:R:E189 R:R:I188 4.1 0 No No 6 5 2 1
R:R:G192 R:R:V191 3.68 0 No Yes 5 4 2 1
R:R:Y245 R:R:Y273 3.97 0 Yes Yes 7 5 2 1
R:R:R256 R:R:Y252 6.17 1 Yes Yes 3 4 1 1
R:R:R270 R:R:Y252 3.09 1 No Yes 4 4 2 1
R:R:Y252 R:R:Y273 10.92 1 Yes Yes 4 5 1 1
R:R:R256 R:R:R270 7.46 1 Yes No 3 4 1 2
R:R:P274 R:R:Y273 5.56 0 No Yes 5 5 2 1
R:R:V269 R:R:Y252 2.52 0 Yes Yes 5 4 2 1
R:R:M100 R:R:Y101 2.39 0 No Yes 8 7 2 1
R:R:M100 R:R:Y245 2.39 0 No Yes 8 7 2 2
L:L:?1 R:R:A151 2.25 1 Yes No 0 4 0 1
R:R:I190 R:R:V191 1.54 0 No Yes 4 4 2 1
L:L:?1 R:R:T143 1.05 1 Yes No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9ITB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.69
Number of Linked Nodes 245
Number of Links 258
Number of Hubs 28
Number of Links mediated by Hubs 113
Number of Communities 7
Number of Nodes involved in Communities 36
Number of Links involved in Communities 46
Path Summary
Number Of Nodes in MetaPath 66
Number Of Links MetaPath 65
Number of Shortest Paths 28516
Length Of Smallest Path 3
Average Path Length 13.8486
Length of Longest Path 34
Minimum Path Strength 1.4
Average Path Strength 5.45877
Maximum Path Strength 16.79
Minimum Path Correlation 0.7
Average Path Correlation 0.924773
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 47.2172
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 32.8198
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNKP
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeNKP
Name(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms18:1 LPA; oleoyl lysophosphatidic acid
Identifier
FormulaC21 H41 O7 P
Molecular Weight436.52
SMILES
PubChem49837858
Formal Charge0
Total Atoms70
Total Chiral Atoms1
Total Bonds69
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP43657
Sequence
>9ITB_nogp_Chain_R
CFYNDSFKY TLYGCMFSM VFVLGLISN CVAIYIFCV LKVRNETTT 
YMINLAMSD LLFVFTLPF RIFYFTTRN WPFGDLLCK ISVMLFYTN 
MYGSILFLT CISVDRFLA IVYPFKSKT LRTKRNAKI VCTGVWLTV 
IGGSAPAVF VQSTHACFE NFPEATWKT YLSRIVIFI EIVGFFIPL 
ILNVTCSSM VLKTLTKPN KTKVLKMIF VHLIIFCFC FVPYNINLI 
LYSLVRTQT FVNCSVVAA VRTMYPITL CIAVSNCCF DPIVYYFTA 
R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9ITBALipidLysophospholipidLPA6Homo sapiensLPA-chim(NtGi1-Gs-CtGq)/β1/γ22.892025-01-15doi.org/10.1073/pnas.2415426122
9ITB (No Gprot) ALipidLysophospholipidLPA6Homo sapiensLPA-2.892025-01-15doi.org/10.1073/pnas.2415426122
9ITEALipidLysophospholipidLPA6Homo sapiensLPA-chim(NtGi2-G13)/β1/γ23.062025-01-15doi.org/10.1073/pnas.2415426122
9ITE (No Gprot) ALipidLysophospholipidLPA6Homo sapiensLPA-3.062025-01-15doi.org/10.1073/pnas.2415426122
5XSZALipidLysophospholipidLPA6Danio rerioGlyceryl-mono-oleate--3.22017-08-1610.1038/nature23448




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Download 9ITB_nogp.zip



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