psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y97	10.07	Yes	Yes	0	0	5
2	L:L:?1	R:R:Y101	3.36	Yes	No	1	0	7
3	L:L:?1	R:R:S148	3.22	Yes	No	0	0	7
4	L:L:?1	R:R:F172	3.49	Yes	Yes	1	0	5
5	L:L:?1	R:R:W177	11.41	Yes	Yes	1	0	1
6	L:L:?1	R:R:I188	5.11	Yes	No	1	0	5
7	L:L:?1	R:R:Y252	5.87	Yes	Yes	1	0	4
8	L:L:?1	R:R:R256	6.95	Yes	Yes	1	0	3
9	L:L:?1	R:R:Y273	4.19	Yes	Yes	1	0	5
10	R:R:C263	R:R:C9	7.28	No	No	0	6	9
11	R:R:D13	R:R:Y11	6.9	No	No	0	5	3
12	R:R:R270	R:R:Y11	22.64	No	No	0	4	3
13	R:R:N12	R:R:S14	2.98	No	No	0	5	4
14	R:R:F15	R:R:L19	3.65	No	No	0	6	5
15	R:R:F15	R:R:T271	2.59	No	No	0	6	1
16	R:R:F15	R:R:P274	2.89	No	Yes	0	6	5
17	R:R:K16	R:R:Y17	7.17	No	Yes	0	2	4
18	R:R:K16	R:R:P274	5.02	No	Yes	0	2	5
19	R:R:F77	R:R:Y17	4.13	Yes	Yes	2	4	4
20	R:R:R80	R:R:Y17	19.55	No	Yes	0	4	4
21	R:R:E170	R:R:Y17	5.61	Yes	Yes	2	4	4
22	R:R:C278	R:R:L19	3.17	No	No	0	5	5
23	R:R:F24	R:R:Y20	3.09	No	Yes	0	8	5
24	R:R:F77	R:R:Y20	10.32	Yes	Yes	0	4	5
25	R:R:P274	R:R:Y20	5.56	Yes	Yes	0	5	5
26	R:R:C278	R:R:Y20	2.69	No	Yes	0	5	5
27	R:R:C278	R:R:M23	6.48	No	No	0	5	5
28	R:R:F24	R:R:I74	2.51	No	No	0	8	7
29	R:R:F24	R:R:V281	2.62	No	No	0	8	7
30	R:R:L70	R:R:V27	2.98	No	No	0	8	7
31	R:R:V27	R:R:V281	3.21	No	No	0	7	7
32	R:R:F28	R:R:L32	3.65	No	No	0	7	6
33	R:R:F28	R:R:V67	2.62	No	No	0	7	5
34	R:R:F28	R:R:P71	7.22	No	No	0	7	9
35	R:R:L30	R:R:S34	3	No	No	0	5	7
36	R:R:C285	R:R:L30	4.76	No	No	0	8	5
37	R:R:D63	R:R:N35	4.04	No	No	0	9	9
38	R:R:N35	R:R:P288	8.15	No	No	0	9	9
39	R:R:I41	R:R:V37	3.07	No	No	0	7	6
40	R:R:A38	R:R:Y292	5.34	No	Yes	0	8	7
41	R:R:C44	R:R:Y40	2.69	No	No	0	5	3
42	R:R:V45	R:R:Y40	5.05	No	No	0	5	3
43	R:R:F293	R:R:I41	3.77	No	No	0	7	7
44	R:R:F42	R:R:M56	3.73	No	No	0	7	8
45	R:R:F42	R:R:Y292	3.09	No	Yes	0	7	7
46	R:R:S301	R:R:V45	3.23	No	No	0	4	5
47	R:R:L46	R:R:V48	5.96	Yes	No	0	6	6
48	R:R:I298	R:R:L46	4.28	No	Yes	0	8	6
49	R:R:N50	R:R:T53	5.85	No	No	0	7	7
50	R:R:E51	R:R:R128	3.49	No	Yes	0	7	7
51	R:R:A133	R:R:E51	3.02	No	No	0	8	7
52	R:R:M56	R:R:T52	4.52	No	No	0	8	7
53	R:R:C109	R:R:Y55	5.38	No	Yes	0	6	7
54	R:R:I110	R:R:Y55	3.63	No	Yes	0	9	7
55	R:R:A133	R:R:Y55	2.67	No	Yes	0	8	7
56	R:R:C137	R:R:Y55	2.69	No	Yes	0	7	7
57	R:R:I57	R:R:M61	2.92	No	No	0	6	5
58	R:R:F106	R:R:N58	9.67	No	No	0	8	9
59	R:R:C137	R:R:N58	6.3	No	No	0	7	9
60	R:R:L59	R:R:S103	3	No	No	3	9	9
61	R:R:L107	R:R:L59	4.15	Yes	No	3	8	9
62	R:R:D287	R:R:L59	2.71	Yes	No	3	9	9
63	R:R:S62	R:R:W141	3.71	No	Yes	0	8	9
64	R:R:D63	R:R:S103	2.94	No	No	0	9	9
65	R:R:D287	R:R:D63	3.99	Yes	No	0	9	9
66	R:R:F68	R:R:L64	8.53	No	No	0	4	7
67	R:R:L65	R:R:N99	5.49	No	No	0	6	8
68	R:R:F66	R:R:F96	8.57	Yes	No	0	7	6
69	R:R:F66	R:R:N99	4.83	Yes	No	0	7	8
70	R:R:F66	R:R:M100	2.49	Yes	No	0	7	8
71	R:R:F66	R:R:V281	3.93	Yes	No	0	7	7
72	R:R:L95	R:R:T69	2.95	No	No	0	5	6
73	R:R:F96	R:R:T69	5.19	No	No	0	6	6
74	R:R:R73	R:R:Y76	6.17	No	Yes	2	6	5
75	R:R:F77	R:R:R73	5.34	Yes	No	2	4	6
76	R:R:F75	R:R:T79	11.67	No	No	0	4	3
77	R:R:F77	R:R:Y76	5.16	Yes	Yes	2	4	5
78	R:R:W82	R:R:Y76	2.89	Yes	Yes	2	8	5
79	R:R:A167	R:R:Y76	4	No	Yes	0	4	5
80	R:R:E170	R:R:Y76	13.47	Yes	Yes	2	4	5
81	R:R:E170	R:R:F77	4.66	Yes	Yes	2	4	4
82	R:R:N81	R:R:P83	11.4	No	No	0	4	2
83	R:R:F84	R:R:W82	8.02	Yes	Yes	2	7	8
84	R:R:L88	R:R:W82	5.69	No	Yes	2	6	8
85	R:R:C89	R:R:W82	3.92	No	Yes	0	9	8
86	R:R:F84	R:R:P83	5.78	Yes	No	0	7	2
87	R:R:F84	R:R:L88	7.31	Yes	No	2	7	6
88	R:R:D86	R:R:K90	2.77	No	No	4	4	7
89	R:R:D86	R:R:S156	8.83	No	Yes	4	4	4
90	R:R:D86	R:R:T157	7.23	No	No	4	4	5
91	R:R:C168	R:R:C89	7.28	No	No	0	9	9
92	R:R:K90	R:R:V152	3.04	No	No	0	7	4
93	R:R:K90	R:R:S156	6.12	No	Yes	4	7	4
94	R:R:I91	R:R:L95	2.85	No	No	0	5	5
95	R:R:V93	R:R:Y97	2.52	No	Yes	0	6	5
96	R:R:F169	R:R:V93	11.8	No	No	0	4	6
97	R:R:M94	R:R:S148	7.67	No	No	0	6	7
98	R:R:F96	R:R:Y97	8.25	No	Yes	0	6	5
99	R:R:Y245	R:R:Y97	2.98	Yes	Yes	0	7	5
100	R:R:T98	R:R:V144	3.17	No	No	0	5	7
101	R:R:S148	R:R:T98	3.2	No	No	0	7	5
102	R:R:I188	R:R:Y101	7.25	No	No	1	5	7
103	R:R:N246	R:R:Y101	5.81	No	No	0	8	7
104	R:R:L107	R:R:S103	3	Yes	No	3	8	9
105	R:R:I104	R:R:P196	3.39	No	No	0	8	9
106	R:R:F238	R:R:I104	2.51	No	No	3	9	8
107	R:R:F242	R:R:I104	6.28	No	No	3	9	8
108	R:R:L105	R:R:V140	4.47	No	No	0	6	7
109	R:R:F106	R:R:V140	7.87	No	No	0	8	7
110	R:R:F106	R:R:W141	5.01	No	Yes	0	8	9
111	R:R:F238	R:R:L107	4.87	No	Yes	3	9	8
112	R:R:D287	R:R:L107	2.71	Yes	Yes	3	9	8
113	R:R:L107	R:R:Y291	4.69	Yes	No	0	8	9
114	R:R:P196	R:R:T108	6.99	No	No	0	9	7
115	R:R:L199	R:R:T108	2.95	No	No	0	6	7
116	R:R:I110	R:R:R114	5.01	No	No	0	9	9
117	R:R:I110	R:R:Y291	3.63	No	No	0	9	9
118	R:R:N200	R:R:S111	7.45	No	No	0	7	9
119	R:R:D113	R:R:R128	11.91	No	Yes	0	8	7
120	R:R:H234	R:R:R114	7.9	Yes	No	0	7	9
121	R:R:F115	R:R:V119	6.55	Yes	No	0	8	7
122	R:R:C203	R:R:F115	9.78	No	Yes	0	7	8
123	R:R:F115	R:R:M206	3.73	Yes	No	0	8	3
124	R:R:F115	R:R:V207	2.62	Yes	Yes	0	8	8
125	R:R:A117	R:R:R128	6.91	No	Yes	0	8	7
126	R:R:I118	R:R:V207	6.14	No	Yes	0	8	8
127	R:R:T210	R:R:V119	3.17	No	No	0	5	7
128	R:R:N132	R:R:T129	7.31	No	No	0	2	7
129	R:R:V144	R:R:W141	2.45	No	Yes	0	7	9
130	R:R:P150	R:R:Y180	2.78	No	No	0	8	1
131	R:R:I184	R:R:P150	5.08	No	No	0	5	8
132	R:R:F153	R:R:V152	2.62	No	No	0	3	4
133	R:R:V154	R:R:Y180	3.79	No	No	0	5	1
134	R:R:S156	R:R:T157	3.2	Yes	No	4	4	5
135	R:R:C168	R:R:S156	3.44	No	Yes	0	9	4
136	R:R:F169	R:R:S156	2.64	No	Yes	0	4	4
137	R:R:F169	R:R:F172	7.5	No	Yes	0	4	5
138	R:R:E170	R:R:N171	2.63	Yes	No	0	4	4
139	R:R:F172	R:R:P173	4.33	Yes	No	0	5	4
140	R:R:F172	R:R:W177	3.01	Yes	Yes	1	5	1
141	R:R:P173	R:R:T176	3.5	No	No	0	4	2
142	R:R:E174	R:R:R256	3.49	No	Yes	0	1	3
143	R:R:L181	R:R:W177	11.39	No	Yes	0	4	1
144	R:R:R256	R:R:W177	15.99	Yes	Yes	1	3	1
145	R:R:K178	R:R:T257	4.5	No	No	0	1	1
146	R:R:I184	R:R:I188	2.94	No	No	0	5	5
147	R:R:S253	R:R:V185	3.23	No	No	0	5	5
148	R:R:I186	R:R:I190	2.94	No	No	0	4	4
149	R:R:F187	R:R:V191	7.87	No	No	0	3	4
150	R:R:E189	R:R:N246	11.83	No	No	0	6	8
151	R:R:E189	R:R:L249	3.98	No	No	0	6	5
152	R:R:E189	R:R:I250	12.3	No	No	0	6	6
153	R:R:F193	R:R:F194	6.43	Yes	No	0	8	4
154	R:R:F193	R:R:L197	3.65	Yes	No	0	8	7
155	R:R:F193	R:R:V243	6.55	Yes	Yes	0	8	6
156	R:R:F193	R:R:N246	19.33	Yes	No	0	8	8
157	R:R:I195	R:R:P196	3.39	No	No	0	6	9
158	R:R:I195	R:R:L199	2.85	No	No	0	6	6
159	R:R:L197	R:R:V201	2.98	No	No	0	7	5
160	R:R:K209	R:R:M206	5.76	No	No	0	4	3
161	R:R:I231	R:R:L208	4.28	No	No	0	7	4
162	R:R:L228	R:R:T212	2.95	No	No	0	5	4
163	R:R:K213	R:R:P214	3.35	No	No	0	4	6
164	R:R:K213	R:R:V215	6.07	No	No	0	4	4
165	R:R:K213	R:R:T216	4.5	No	No	0	4	4
166	R:R:I222	R:R:L217	2.85	No	No	0	3	2
167	R:R:K224	R:R:L217	8.46	No	No	0	6	2
168	R:R:K221	R:R:S218	4.59	No	No	0	2	3
169	R:R:N223	R:R:T225	4.39	No	No	0	5	5
170	R:R:D296	R:R:K226	9.68	No	No	0	5	7
171	R:R:I231	R:R:V227	3.07	No	No	0	7	7
172	R:R:H234	R:R:M230	3.94	Yes	No	0	7	7
173	R:R:M230	R:R:T294	4.52	No	No	0	7	7
174	R:R:F232	R:R:I236	2.51	No	No	0	4	5
175	R:R:I237	R:R:V233	3.07	No	No	0	7	5
176	R:R:H234	R:R:V290	5.54	Yes	No	0	7	7
177	R:R:H234	R:R:Y291	13.07	Yes	No	0	7	9
178	R:R:I237	R:R:V290	4.61	No	No	0	7	7
179	R:R:F238	R:R:F242	5.36	No	No	3	9	9
180	R:R:C241	R:R:F286	2.79	No	No	0	8	7
181	R:R:F242	R:R:N283	8.46	No	No	0	9	9
182	R:R:P244	R:R:V243	3.53	No	Yes	0	9	6
183	R:R:Y245	R:R:Y273	5.96	Yes	Yes	0	7	5
184	R:R:T276	R:R:Y245	4.99	No	Yes	0	7	7
185	R:R:L277	R:R:Y245	8.21	No	Yes	0	6	7
186	R:R:N248	R:R:V269	2.96	No	Yes	0	5	5
187	R:R:M272	R:R:N248	2.8	No	No	0	5	5
188	R:R:N248	R:R:T276	4.39	No	No	0	5	7
189	R:R:L251	R:R:V269	2.98	No	Yes	0	4	5
190	R:R:R256	R:R:Y252	4.12	Yes	Yes	1	3	4
191	R:R:V269	R:R:Y252	2.52	Yes	Yes	0	5	4
192	R:R:Y252	R:R:Y273	10.92	Yes	Yes	1	4	5
193	R:R:L254	R:R:T259	4.42	No	No	0	4	1
194	R:R:F260	R:R:L254	4.87	No	No	0	3	4
195	R:R:V255	R:R:V266	4.81	No	No	0	3	2
196	R:R:V255	R:R:V269	4.81	No	Yes	0	3	5
197	R:R:R256	R:R:R270	8.53	Yes	No	0	3	4
198	R:R:T257	R:R:T259	3.14	No	No	0	1	1
199	R:R:N262	R:R:S264	7.45	No	No	0	5	3
200	R:R:S264	R:R:V265	3.23	No	No	0	3	1
201	R:R:I275	R:R:M272	5.83	No	No	0	5	5
202	R:R:P274	R:R:Y273	4.17	Yes	Yes	0	5	5
203	R:R:D287	R:R:N283	12.12	Yes	No	0	9	9
204	R:R:P288	R:R:Y292	5.56	No	Yes	0	9	7
205	R:R:F293	R:R:Y292	5.16	No	Yes	0	7	7
206	R:R:N300	R:R:S301	4.47	No	No	0	5	4
207	R:R:F68	R:R:L32	2.44	No	No	0	4	6
208	R:R:F42	R:R:L46	2.44	No	Yes	0	7	6
209	R:R:I145	R:R:W141	2.35	No	Yes	0	3	9
210	L:L:?1	R:R:A151	2.25	Yes	No	0	0	4
211	L:L:?1	R:R:V185	2.13	Yes	No	0	0	5
212	L:L:?1	R:R:V191	2.13	Yes	No	0	0	4
213	R:R:G146	R:R:G147	2.11	No	No	0	4	5
214	R:R:F115	R:R:Y120	2.06	Yes	No	0	8	6
215	R:R:C284	R:R:G31	1.96	No	No	0	8	8
216	R:R:A149	R:R:P150	1.87	No	No	0	4	8
217	R:R:G31	R:R:V67	1.84	No	No	0	8	5
218	R:R:G102	R:R:V144	1.84	No	No	0	7	7
219	R:R:A43	R:R:C44	1.81	No	No	0	4	5
220	R:R:P288	R:R:S34	1.78	No	No	0	9	7
221	R:R:G21	R:R:I74	1.76	No	No	0	5	7
222	R:R:C9	R:R:V266	1.71	No	No	0	9	2
223	R:R:G31	R:R:L30	1.71	No	No	0	8	5
224	R:R:C109	R:R:V136	1.71	No	No	0	6	5
225	R:R:C203	R:R:V112	1.71	No	No	0	7	6
226	R:R:C239	R:R:V243	1.71	No	Yes	0	6	6
227	R:R:C137	R:R:T54	1.69	No	No	0	7	7
228	R:R:C241	R:R:I237	1.64	No	No	0	8	7
229	R:R:A60	R:R:I39	1.62	No	No	0	8	7
230	R:R:A117	R:R:I118	1.62	No	No	0	8	8
231	R:R:A280	R:R:M100	1.61	No	No	0	8	8
232	R:R:V265	R:R:V266	1.6	No	No	0	1	2
233	R:R:S295	R:R:T297	1.6	No	No	0	7	6
234	R:R:C36	R:R:L32	1.59	No	No	0	4	6
235	R:R:C36	R:R:L64	1.59	No	No	0	4	7
236	R:R:T78	R:R:T79	1.57	No	No	0	4	3
237	R:R:I279	R:R:S282	1.55	No	No	0	7	5
238	R:R:I231	R:R:V207	1.54	No	Yes	0	7	8
239	R:R:I247	R:R:V243	1.54	No	Yes	0	6	6
240	R:R:I289	R:R:V290	1.54	No	No	0	7	7
241	R:R:I198	R:R:T202	1.52	No	No	0	4	4
242	R:R:I298	R:R:T297	1.52	No	No	0	8	6
243	R:R:F84	R:R:G85	1.51	Yes	No	0	7	7
244	R:R:F187	R:R:G147	1.51	No	No	0	3	5
245	R:R:L116	R:R:S124	1.5	No	No	0	5	6
246	R:R:K178	R:R:T179	1.5	No	No	0	1	4
247	R:R:L235	R:R:S204	1.5	No	No	0	8	8
248	R:R:N81	R:R:S165	1.49	No	No	0	4	2
249	R:R:N200	R:R:S204	1.49	No	No	0	7	8
250	R:R:L235	R:R:V201	1.49	No	No	0	8	5
251	R:R:L211	R:R:V207	1.49	No	Yes	0	8	8
252	R:R:L211	R:R:V227	1.49	No	No	0	8	7
253	R:R:L46	R:R:T53	1.47	Yes	No	0	6	7
254	R:R:L127	R:R:T126	1.47	No	No	0	4	4
255	R:R:I39	R:R:M61	1.46	No	No	0	7	5
256	R:R:I222	R:R:K221	1.45	No	No	0	3	2
257	R:R:M23	R:R:M26	1.44	No	No	0	5	4
258	R:R:I91	R:R:L87	1.43	No	No	0	5	3
259	R:R:I57	R:R:N58	1.42	No	No	0	6	9
260	R:R:I135	R:R:N132	1.42	No	No	0	3	2
261	R:R:K130	R:R:N50	1.4	No	No	0	3	7
262	R:R:P121	R:R:Y120	1.39	No	No	0	8	6
263	R:R:L208	R:R:L228	1.38	No	No	0	4	5
264	R:R:F72	R:R:S92	1.32	No	No	0	7	5
265	R:R:R73	R:R:S92	1.32	No	No	0	6	5
266	R:R:F286	R:R:S282	1.32	No	No	0	7	5
267	R:R:F260	R:R:V255	1.31	No	No	0	3	3
268	R:R:F260	R:R:V265	1.31	No	No	0	3	1
269	R:R:R131	R:R:T129	1.29	No	No	0	4	7
270	R:R:R166	R:R:T157	1.29	No	No	0	4	5
271	R:R:F240	R:R:I279	1.26	No	No	0	6	7
272	R:R:F232	R:R:L208	1.22	No	No	0	4	4
273	R:R:L116	R:R:R128	1.21	No	Yes	0	5	7
274	R:R:F75	R:R:F84	1.07	No	Yes	0	4	7
275	L:L:?1	R:R:T143	1.05	Yes	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	4.71	13	1	0
2	R:R:Y17	9.115	4	2	4
3	R:R:Y20	5.415	4	0	5
4	R:R:L46	3.5375	4	0	6
5	R:R:Y55	3.5925	4	0	7
6	R:R:F66	4.955	4	0	7
7	R:R:Y76	6.338	5	2	5
8	R:R:F77	5.922	5	2	4
9	R:R:W82	5.13	4	2	8
10	R:R:F84	4.738	5	2	7
11	R:R:Y97	5.955	4	0	5
12	R:R:L107	3.884	5	3	8
13	R:R:F115	4.948	5	0	8
14	R:R:R128	5.88	4	0	7
15	R:R:W141	3.38	4	0	9
16	R:R:S156	4.846	5	4	4
17	R:R:E170	6.5925	4	2	4
18	R:R:F172	4.5825	4	1	5
19	R:R:W177	10.45	4	1	1
20	R:R:F193	8.99	4	0	8
21	R:R:V207	2.9475	4	0	8
22	R:R:H234	7.6125	4	0	7
23	R:R:V243	3.3325	4	0	6
24	R:R:Y245	5.535	4	0	7
25	R:R:Y252	5.8575	4	1	4
26	R:R:R256	7.816	5	1	3
27	R:R:V269	3.3175	4	0	5
28	R:R:Y273	6.31	4	1	5
29	R:R:P274	4.41	4	0	5
30	R:R:D287	5.3825	4	3	9
31	R:R:Y292	4.7875	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y252	21.8732	5.87	Yes	Yes	1	0	4
2	R:R:V269	R:R:Y252	25.7223	2.52	Yes	Yes	0	5	4
3	R:R:V255	R:R:V269	20.5142	4.81	No	Yes	0	3	5
4	L:L:?1	R:R:Y273	34.5229	4.19	Yes	Yes	1	0	5
5	R:R:P274	R:R:Y273	37.0367	4.17	Yes	Yes	0	5	5
6	R:R:P274	R:R:Y20	27.7324	5.56	Yes	Yes	0	5	5
7	R:R:F77	R:R:Y20	21.8685	10.32	Yes	Yes	0	4	5
8	L:L:?1	R:R:Y97	18.0859	10.07	Yes	Yes	0	0	5
9	R:R:F96	R:R:Y97	15.0542	8.25	No	Yes	0	6	5
10	L:L:?1	R:R:S148	99.7244	3.22	Yes	No	0	0	7
11	R:R:S148	R:R:T98	99.9287	3.2	No	No	0	7	5
12	R:R:T98	R:R:V144	99.962	3.17	No	No	0	5	7
13	R:R:V144	R:R:W141	100	2.45	No	Yes	0	7	9
14	R:R:F106	R:R:W141	99.9857	5.01	No	Yes	0	8	9
15	R:R:F106	R:R:N58	99.886	9.67	No	No	0	8	9
16	R:R:C137	R:R:N58	99.5296	6.3	No	No	0	7	9
17	R:R:C137	R:R:Y55	99.3205	2.69	No	Yes	0	7	7
18	R:R:I110	R:R:Y55	91.9074	3.63	No	Yes	0	9	7
19	R:R:I110	R:R:Y291	80.6453	3.63	No	No	0	9	9
20	R:R:L107	R:R:Y291	74.3918	4.69	Yes	No	0	8	9
21	R:R:L107	R:R:S103	33.1353	3	Yes	No	3	8	9
22	R:R:D63	R:R:S103	32.4273	2.94	No	No	0	9	9
23	R:R:D63	R:R:N35	64.1323	4.04	No	No	0	9	9
24	R:R:N35	R:R:P288	62.1982	8.15	No	No	0	9	9
25	R:R:P288	R:R:S34	28.103	1.78	No	No	0	9	7
26	R:R:L30	R:R:S34	25.9979	3	No	No	0	5	7
27	R:R:G31	R:R:L30	21.7592	1.71	No	No	0	8	5
28	R:R:G31	R:R:V67	17.4824	1.84	No	No	0	8	5
29	R:R:F28	R:R:V67	15.3298	2.62	No	No	0	7	5
30	R:R:D287	R:R:L107	34.1047	2.71	Yes	Yes	3	9	8
31	R:R:D287	R:R:D63	33.6438	3.99	Yes	No	0	9	9
32	R:R:F28	R:R:L32	10.996	3.65	No	No	0	7	6
33	R:R:P288	R:R:Y292	34.1237	5.56	No	Yes	0	9	7
34	R:R:F42	R:R:Y292	23.6409	3.09	No	Yes	0	7	7
35	R:R:F42	R:R:L46	17.4824	2.44	No	Yes	0	7	6
36	R:R:A133	R:R:Y55	33.2161	2.67	No	Yes	0	8	7
37	R:R:A133	R:R:E51	32.0804	3.02	No	No	0	8	7
38	R:R:F77	R:R:Y76	14.9116	5.16	Yes	Yes	2	4	5
39	L:L:?1	R:R:F172	22.9994	3.49	Yes	Yes	1	0	5
40	R:R:F169	R:R:F172	20.5379	7.5	No	Yes	0	4	5
41	R:R:F169	R:R:S156	20.8658	2.64	No	Yes	0	4	4
42	R:R:C168	R:R:S156	13.2817	3.44	No	Yes	0	9	4
43	R:R:C168	R:R:C89	12.26	7.28	No	No	0	9	9
44	R:R:C89	R:R:W82	11.2859	3.92	No	Yes	0	9	8
45	R:R:F84	R:R:W82	18.1667	8.02	Yes	Yes	2	7	8
46	R:R:W82	R:R:Y76	13.4243	2.89	Yes	Yes	2	8	5
47	L:L:?1	R:R:Y101	21.6309	3.36	Yes	No	1	0	7
48	R:R:N246	R:R:Y101	20.9799	5.81	No	No	0	8	7
49	R:R:F238	R:R:L107	10.0266	4.87	No	Yes	3	9	8
50	R:R:F193	R:R:N246	15.9618	19.33	Yes	No	0	8	8
51	R:R:E51	R:R:R128	30.9067	3.49	No	Yes	0	7	7
52	R:R:A117	R:R:R128	26.4588	6.91	No	Yes	0	8	7
53	R:R:A117	R:R:I118	25.3802	1.62	No	No	0	8	8
54	R:R:I118	R:R:V207	24.1637	6.14	No	Yes	0	8	8
55	R:R:F115	R:R:V207	12.0985	2.62	Yes	Yes	0	8	8
56	R:R:F260	R:R:V255	11.6708	1.31	No	No	0	3	3
57	R:R:H234	R:R:Y291	15.3345	13.07	Yes	No	0	7	9
58	R:R:I110	R:R:R114	11.533	5.01	No	No	0	9	9
59	R:R:H234	R:R:R114	10.7679	7.9	Yes	No	0	7	9
60	R:R:H234	R:R:V290	19.54	5.54	Yes	No	0	7	7
61	R:R:I237	R:R:V290	15.3583	4.61	No	No	0	7	7
62	R:R:C241	R:R:I237	11.0198	1.64	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y97	10.07	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y101	3.36	1	Yes	No	0	7	0	1
L:L:?1	R:R:S148	3.22	1	Yes	No	0	7	0	1
L:L:?1	R:R:F172	3.49	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W177	11.41	1	Yes	Yes	0	1	0	1
L:L:?1	R:R:I188	5.11	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y252	5.87	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R256	6.95	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y273	4.19	1	Yes	Yes	0	5	0	1
R:R:V93	R:R:Y97	2.52	0	No	Yes	6	5	2	1
R:R:F169	R:R:V93	11.8	0	No	No	4	6	2	2
R:R:M94	R:R:S148	7.67	0	No	No	6	7	2	1
R:R:F96	R:R:Y97	8.25	0	No	Yes	6	5	2	1
R:R:Y245	R:R:Y97	2.98	0	Yes	Yes	7	5	2	1
R:R:S148	R:R:T98	3.2	0	No	No	7	5	1	2
R:R:I188	R:R:Y101	7.25	1	No	No	5	7	1	1
R:R:N246	R:R:Y101	5.81	0	No	No	8	7	2	1
R:R:F169	R:R:F172	7.5	0	No	Yes	4	5	2	1
R:R:F172	R:R:P173	4.33	1	Yes	No	5	4	1	2
R:R:F172	R:R:W177	3.01	1	Yes	Yes	5	1	1	1
R:R:E174	R:R:R256	3.49	0	No	Yes	1	3	2	1
R:R:L181	R:R:W177	11.39	0	No	Yes	4	1	2	1
R:R:R256	R:R:W177	15.99	1	Yes	Yes	3	1	1	1
R:R:I184	R:R:I188	2.94	0	No	No	5	5	2	1
R:R:S253	R:R:V185	3.23	0	No	No	5	5	2	1
R:R:F187	R:R:V191	7.87	0	No	No	3	4	2	1
R:R:Y245	R:R:Y273	5.96	0	Yes	Yes	7	5	2	1
R:R:R256	R:R:Y252	4.12	1	Yes	Yes	3	4	1	1
R:R:V269	R:R:Y252	2.52	0	Yes	Yes	5	4	2	1
R:R:Y252	R:R:Y273	10.92	1	Yes	Yes	4	5	1	1
R:R:R256	R:R:R270	8.53	1	Yes	No	3	4	1	2
R:R:P274	R:R:Y273	4.17	0	Yes	Yes	5	5	2	1
L:L:?1	R:R:A151	2.25	1	Yes	No	0	4	0	1
L:L:?1	R:R:V185	2.13	1	Yes	No	0	5	0	1
L:L:?1	R:R:V191	2.13	1	Yes	No	0	4	0	1
L:L:?1	R:R:T143	1.05	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9ITE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.45
Number of Linked Nodes	258
Number of Links	275
Number of Hubs	31
Number of Links mediated by Hubs	114
Number of Communities	4
Number of Nodes involved in Communities	27
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	38625
Length Of Smallest Path	3
Average Path Length	16.1356
Length of Longest Path	34
Minimum Path Strength	1.29
Average Path Strength	4.62873
Maximum Path Strength	15.72
Minimum Path Correlation	0.7
Average Path Correlation	0.929338
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.882
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.2134
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • developmental process • multicellular organismal process • chordate embryonic development • embryo development • in utero embryonic development • multicellular organism development • hatching • embryo development ending in birth or egg hatching • blastocyst hatching • anatomical structure development • organism emergence from protective structure • blastocyst development • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NKP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NKP
Name	(2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate
Synonyms	18:1 LPA; oleoyl lysophosphatidic acid
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	49837858
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43657
Sequence	>9ITE_nogp_Chain_R H C F Y N D S F K Y T L Y G C M F S M V F V L G L I S N C V A I Y I F C V L K V R N E T T T Y M I N L A M S D L L F V F T L P F R I F Y F T T R N W P F G D L L C K I S V M L F Y T N M Y G S I L F L T C I S V D R F L A I V Y P F K S K T L R T K R N A K I V C T G V W L T V I G G S A P A V F V Q S T H A S A C F E N F P E A T W K T Y L S R I V I F I E I V G F F I P L I L N V T C S S M V L K T L T K P V T L S R S K I N K T K V L K M I F V H L I I F C F C F V P Y N I N L I L Y S L V R T Q T F V N C S V V A A V R T M Y P I T L C I A V S N C C F D P I V Y Y F T S D T I Q N S A R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5XSZ	A	Lipid	Lysophospholipid	LPA₆	Danio rerio	Glyceryl-mono-oleate	-	-	3.2	2017-08-16	doi.org/10.1038/nature23448
	9ITB	A	Lipid	Lysophospholipid	LPA₆	Homo sapiens	LPA	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.89	2025-01-15	doi.org/10.1073/pnas.2415426122
	9ITB (No Gprot)	A	Lipid	Lysophospholipid	LPA₆	Homo sapiens	LPA	-		2.89	2025-01-15	doi.org/10.1073/pnas.2415426122
	9ITE	A	Lipid	Lysophospholipid	LPA₆	Homo sapiens	LPA	-	chim(NtGi2-G13)/β1/γ2	3.06	2025-01-15	doi.org/10.1073/pnas.2415426122
	9ITE (No Gprot)	A	Lipid	Lysophospholipid	LPA₆	Homo sapiens	LPA	-		3.06	2025-01-15	doi.org/10.1073/pnas.2415426122

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.