Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 6.072514
2A:A:R38 5.69414
3A:A:L41 4.066536
4A:A:L43 3.87437
5A:A:L45 3.86438
6A:A:L46 5.106518
7A:A:K53 4.15539
8A:A:I207 3.1425419
9A:A:V214 4.096536
10A:A:V217 4.485435
11A:A:F219 6.33667638
12A:A:H220 7.69417
13A:A:M221 4.4075438
14A:A:F222 8.382517
15A:A:Q227 4.935419
16A:A:E230 7.645419
17A:A:R231 6.015419
18A:A:K233 4.80571719
19A:A:W234 5.93333619
20A:A:F238 7.83619
21A:A:I244 4.335418
22A:A:I245 3.472537
23A:A:F246 2.906509
24A:A:V248 4.2575407
25A:A:D252 5.2875488
26A:A:L266 3.6975468
27A:A:L270 3.94333666
28A:A:F273 4.807147109
29A:A:I276 3.305418
30A:A:W277 8.676676106
31A:A:W281 9.33333615
32A:A:I288 5.6375409
33A:A:L289 5.4825409
34A:A:F290 4.76333639
35A:A:L291 4.5745118
36A:A:N292 4.032539
37A:A:K293 4.2625409
38A:A:Q294 7.754116
39A:A:V301 3.115487
40A:A:S306 4.9925487
41A:A:I308 6.805487
42A:A:F312 4.14768
43A:A:F315 13.4725406
44A:A:Y318 4.855406
45A:A:P321 4.0154125
46A:A:Y339 5.0454123
47A:A:F340 8.12567
48A:A:R342 7.815404
49A:A:F345 7.97408
50A:A:C359 3.35254105
51A:A:Y360 8.43286738
52A:A:H362 5.89439
53A:A:F363 13.81254115
54A:A:T364 4.985439
55A:A:S366 3.215409
56A:A:D368 3.3825439
57A:A:N371 4.675439
58A:A:R374 3.6725434
59A:A:F376 4.39125838
60A:A:I383 3.6925438
61A:A:L388 3.245628
62A:A:Y391 6.774524
63A:A:L393 3.842528
64B:B:L4 4.19404
65B:B:L14 2.385408
66B:B:R48 4.20333617
67B:B:R49 5.864517
68B:B:L51 7.5925419
69B:B:H54 8.55429719
70B:B:L55 7.525416
71B:B:K57 10.8975419
72B:B:Y59 7.514518
73B:B:M61 5.4675416
74B:B:W63 6.35286717
75B:B:R68 12.1025415
76B:B:L70 6.375415
77B:B:D76 6.53519
78B:B:L79 5.2675497
79B:B:I81 4517
80B:B:W82 10.67719
81B:B:Y85 9.164514
82B:B:N88 5.5525407
83B:B:K89 7.06519
84B:B:H91 4.39415
85B:B:I93 5.265497
86B:B:L95 5.874598
87B:B:W99 9.01719
88B:B:V100 3.28499
89B:B:M101 3.828519
90B:B:C103 2.665408
91B:B:Y111 4.612514
92B:B:C114 3.736598
93B:B:G115 2.4225499
94B:B:L117 3.458519
95B:B:N119 3.925409
96B:B:I123 2.948516
97B:B:Y124 5.606596
98B:B:L139 8.025409
99B:B:H142 6.35619
100B:B:Y145 5.61375818
101B:B:C148 3.89456
102B:B:R150 6.0125456
103B:B:F151 4.37143719
104B:B:L152 4.245403
105B:B:T159 5.03167619
106B:B:S161 6.41419
107B:B:D163 7.45419
108B:B:L168 4.25456
109B:B:W169 9.845618
110B:B:F180 7.612557
111B:B:H183 7.05667659
112B:B:D186 7.112519
113B:B:V187 4.148559
114B:B:L190 3.046555
115B:B:F199 5.51167659
116B:B:V200 6.9125446
117B:B:S201 3.9025459
118B:B:A203 4.3025458
119B:B:C204 5.8325417
120B:B:D205 5.065459
121B:B:K209 9.3075456
122B:B:L210 4.912545
123B:B:W211 8.27429758
124B:B:D212 5.7525449
125B:B:V213 3.1725404
126B:B:R219 2.7075445
127B:B:Q220 5.91547
128B:B:F222 8.046548
129B:B:H225 7.54429749
130B:B:D228 8.815419
131B:B:I232 4.692548
132B:B:F235 7.20833616
133B:B:P236 6.03417
134B:B:N237 9.9415
135B:B:F241 5.98286746
136B:B:T243 4.502548
137B:B:D246 6.85419
138B:B:D247 5.99167649
139B:B:R251 8.40167648
140B:B:F253 6.065646
141B:B:D254 3.78333609
142B:B:L255 3.5725446
143B:B:R256 5.7925409
144B:B:D258 7.438547
145B:B:M262 5.0975414
146B:B:Y264 6.59333615
147B:B:H266 4.0925404
148B:B:I269 3.5725414
149B:B:C271 3.83415
150B:B:T274 3.8518
151B:B:S277 2.8575405
152B:B:F278 7.08417
153B:B:S279 4.2375419
154B:B:S281 4.2375419
155B:B:G282 2.6975419
156B:B:R283 5.28143719
157B:B:L284 3.104515
158B:B:L285 6.935416
159B:B:Y289 5.38714717
160B:B:D290 7.15516
161B:B:N293 5.2625415
162B:B:C294 3.8975415
163B:B:N295 4.586516
164B:B:W297 5.7775418
165B:B:L300 3.446516
166B:B:V307 4.07413
167B:B:H311 7.89619
168B:B:R314 13.266518
169B:B:V315 4.03417
170B:B:S316 3.335419
171B:B:L318 3.20833616
172B:B:T321 7.35417
173B:B:G324 2.365409
174B:B:M325 4.48333615
175B:B:V327 3.2775416
176B:B:T329 5.4175418
177B:B:W332 8.12286719
178B:B:D333 8.18419
179B:B:L336 4.7825417
180B:B:K337 7.588516
181B:B:W339 6.97429719
182B:B:N340 5.096519
183L:L:F5 4.07429720
184L:L:L6 6620
185L:L:H10 8.0375420
186G:G:Q18 6.5675459
187G:G:I25 4.2775442
188G:G:Y40 7.6375416
189G:G:D48 6.398519
190G:G:P49 3.9425407
191G:G:L51 3.185616
192G:G:N59 4.95333619
193G:G:P60 8.01419
194G:G:F61 4.6891018
195R:R:F38 5.31143724
196R:R:F54 5.8225427
197R:R:I58 6.135426
198R:R:N61 6.61409
199R:R:T77 4.985427
200R:R:T78 6.816528
201R:R:Y81 6.175628
202R:R:L82 4.174528
203R:R:M85 4.368509
204R:R:D89 5.5825409
205R:R:F93 4.6475826
206R:R:M96 7.405407
207R:R:L98 6.4375425
208R:R:D99 3.25426
209R:R:R102 3.8225405
210R:R:W109 6.52571727
211R:R:F111 5.676526
212R:R:D113 6.3404
213R:R:F119 6.356524
214R:R:Q120 5.768504
215R:R:F121 6.53667626
216R:R:E124 7.94667624
217R:R:C126 2.9125408
218R:R:Y128 8.08333626
219R:R:I134 3.34428
220R:R:L137 3.5025428
221R:R:E140 7.39529
222R:R:R141 4.09429
223R:R:Y142 7.71508
224R:R:I145 3.6429
225R:R:L149 3.598537
226R:R:K157 2.4075403
227R:R:V160 5.46427
228R:R:W168 5.76509
229R:R:A175 2.97427
230R:R:T190 3.3125473
231R:R:D191 6.83476
232R:R:R199 3.6375423
233R:R:L209 3.746504
234R:R:W215 3.4245184
235R:R:S217 5.3426
236R:R:F220 7.195426
237R:R:F221 6.7275428
238R:R:L228 4.364528
239R:R:Y232 5.68143729
240R:R:I235 3.33428
241R:R:L239 4.4275428
242R:R:F272 6.5575429
243R:R:W276 5.4875828
244R:R:F279 5.456526
245R:R:H280 7.1475427
246R:R:G282 2.72404
247R:R:R283 11.2875426
248R:R:F286 6.55424
249R:R:F290 6.16167621
250R:R:Q302 5.5475423
251R:R:N305 2.82424
252R:R:F309 4.955425
253R:R:F312 4.714527
254R:R:Y313 7.31527
255R:R:L322 3.29408
256R:R:Y323 4.4729
257R:R:Y330 8.33428
258L:L:?1 9.19857720
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:S316 B:B:W332 13.76444.94YesYes199
2A:A:W281 B:B:W332 15.3325.62YesYes159
3A:A:F246 A:A:I276 45.29762.51YesYes098
4A:A:F246 A:A:F273 72.04742.14YesYes099
5A:A:F273 A:A:W277 71.8065.01YesYes1096
6A:A:H357 A:A:W277 90.952722.22NoYes076
7A:A:H357 A:A:S286 90.99561.39NoNo078
8A:A:S286 A:A:Y360 91.01715.09NoYes388
9A:A:D378 A:A:Y360 95.013916.09NoYes378
10A:A:D378 A:A:I288 95.12212.59NoYes079
11A:A:I245 A:A:I288 97.23722.94YesYes079
12A:A:I245 A:A:L43 1005.71YesYes377
13A:A:F219 A:A:L43 60.89963.65YesYes387
14A:A:F219 A:A:L41 39.19317.31YesYes386
15A:A:I383 A:A:L41 78.25932.85YesYes386
16A:A:I383 R:R:P148 43.00993.39YesNo088
17A:A:L384 R:R:P148 64.67716.57NoNo068
18A:A:L384 A:A:L388 64.63112.77NoYes068
19A:A:L388 R:R:I145 11.57132.85YesYes289
20R:R:I145 R:R:I235 11.50414.42YesYes298
21A:A:R280 A:A:R283 18.55485.33NoNo053
22A:A:R283 A:A:R356 18.61257.46NoNo032
23A:A:D354 A:A:R356 18.670416.68NoNo032
24A:A:D354 A:A:S352 18.79988.83NoNo035
25A:A:S352 A:A:W277 18.95416.18NoYes056
26A:A:L43 A:A:T242 39.11592.95YesNo078
27A:A:L41 A:A:T242 39.11654.42YesNo068
28A:A:F219 A:A:F376 21.68952.14YesYes388
29A:A:F376 A:A:K380 21.69086.2YesNo387
30A:A:K380 R:R:P148 21.72323.35NoNo078
31A:A:L388 R:R:L239 11.57224.15YesYes288
32R:R:I235 R:R:L239 11.51422.85YesYes288
33A:A:W234 B:B:Y145 49.17755.79YesYes198
34A:A:R231 A:A:W234 60.38597YesYes199
35A:A:I276 A:A:R231 30.26975.01YesYes189
36A:A:K233 B:B:Y145 23.82333.58YesYes198
37A:A:D272 A:A:R231 30.25534.76NoYes089
38A:A:D272 A:A:F246 30.31562.39NoYes089
39A:A:K233 B:B:D246 22.86385.53YesYes199
40A:A:I383 A:A:N387 35.32394.25YesNo088
41A:A:N387 R:R:A144 35.28434.69NoNo088
42A:A:Y391 R:R:A144 35.20782.67YesNo048
43A:A:L388 A:A:L393 41.20694.15YesYes288
44A:A:Y391 R:R:T78 15.198216.23YesYes248
45A:A:Y391 R:R:E140 12.01088.98YesYes249
46R:R:L137 R:R:T78 14.17862.95YesYes288
47A:A:L393 R:R:R141 30.92383.64YesYes289
48A:A:L393 R:R:L265 10.22294.15YesNo088
49B:B:H142 B:B:S161 10.03049.76YesYes199
50B:B:G162 B:B:Y145 11.01357.24NoYes198
51B:B:G162 B:B:S161 10.93683.71NoYes199
52B:B:D246 B:B:S227 22.74784.42YesNo096
53B:B:D247 B:B:S227 22.60552.94YesNo096
54B:B:D247 B:B:H225 13.61975.04YesYes499
55R:R:I164 R:R:W168 14.27062.35NoYes079
56R:R:E140 R:R:Y81 11.95966.73YesYes298
57R:R:L137 R:R:Y323 13.79635.86YesYes289
58R:R:I134 R:R:Y323 15.14013.63YesYes289
59R:R:F272 R:R:I134 15.02062.51YesYes298
60R:R:F272 R:R:W276 47.825816.04YesYes298
61R:R:F279 R:R:W276 16.6554.01YesYes268
62R:R:F279 R:R:S308 15.63782.64YesNo067
63R:R:N305 R:R:S308 15.20392.98YesNo047
64L:L:F5 R:R:N305 11.74853.62YesYes204
65R:R:R141 R:R:Y323 20.69216.17YesYes299
66R:R:R141 R:R:Y232 10.17124.12YesYes299
67R:R:L228 R:R:Y232 36.119510.55YesYes289
68R:R:F272 R:R:L228 35.82682.44YesYes298
69R:R:L265 R:R:Y232 10.156710.55NoYes089
70R:R:I235 R:R:Y232 20.472.42YesYes289
71R:R:F312 R:R:W276 23.03984.01YesYes278
72R:R:F312 R:R:Y313 22.63722.06YesYes277
73R:R:F309 R:R:Y313 20.07669.28YesYes257
74L:L:F5 R:R:F309 18.71045.36YesYes205
75R:R:N319 R:R:Y323 17.03862.33NoYes099
76R:R:D89 R:R:N319 16.90698.08YesNo099
77R:R:F93 R:R:Y313 13.43736.19YesYes267
78R:R:F172 R:R:W168 12.885810.02NoYes049
79R:R:F121 R:R:F172 12.46987.5YesNo264
80L:L:F5 R:R:F38 14.59943.22YesYes204
81R:R:D99 R:R:Y313 13.20743.45YesYes267
82A:A:F238 A:A:W234 10.32415.01YesYes199
83A:A:R280 B:B:D290 11.06895.96NoYes156
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:G2 R:R:S123 3.71 0 No No 0 6 0 1
L:L:S3 R:R:N305 2.98 2 No Yes 0 4 0 1
L:L:S4 R:R:F286 10.57 0 No Yes 0 4 0 1
L:L:F5 R:R:F38 3.22 2 Yes Yes 0 4 0 1
L:L:F5 R:R:R102 6.41 2 Yes Yes 0 5 0 1
L:L:F5 R:R:L103 2.44 2 Yes No 0 4 0 1
L:L:F5 R:R:Q302 3.51 2 Yes Yes 0 3 0 1
L:L:F5 R:R:N305 3.62 2 Yes Yes 0 4 0 1
L:L:F5 R:R:F309 5.36 2 Yes Yes 0 5 0 1
L:L:L6 R:R:F286 4.87 2 Yes Yes 0 4 0 1
L:L:L6 R:R:S289 9.01 2 Yes No 0 2 0 1
L:L:L6 R:R:F290 3.65 2 Yes Yes 0 1 0 1
L:L:L6 R:R:Q302 5.32 2 Yes Yes 0 3 0 1
L:L:S7 R:R:Y106 8.9 2 No No 0 3 0 1
L:L:S7 R:R:E197 4.31 2 No No 0 4 0 1
L:L:S7 R:R:R199 2.64 2 No Yes 0 3 0 1
L:L:P8 R:R:Q36 6.32 0 No No 0 5 0 1
L:L:P8 R:R:L37 13.14 0 No No 0 5 0 1
L:L:P8 R:R:Y106 9.74 0 No No 0 3 0 1
L:L:H10 R:R:F290 7.92 2 Yes Yes 0 1 0 1
L:L:Q11 R:R:A298 3.03 2 No No 0 3 0 1
L:L:Q11 R:R:Q299 3.84 2 No No 0 1 0 1
R:R:F38 R:R:L37 4.87 2 Yes No 4 5 1 1
R:R:L37 R:R:Q302 3.99 2 No Yes 5 3 1 1
R:R:F38 R:R:L42 2.44 2 Yes No 4 3 1 2
R:R:F38 R:R:L103 2.44 2 Yes No 4 4 1 1
R:R:F38 R:R:Q302 9.37 2 Yes Yes 4 3 1 1
R:R:F38 R:R:L306 13.4 2 Yes No 4 4 1 2
R:R:L306 R:R:L42 4.15 2 No No 4 3 2 2
R:R:L103 R:R:L43 2.77 2 No No 4 5 1 2
R:R:C50 R:R:F309 2.79 0 No Yes 6 5 2 1
R:R:D99 R:R:R102 2.38 2 Yes Yes 6 5 2 1
R:R:D99 R:R:F119 4.78 2 Yes Yes 6 4 2 2
R:R:D99 R:R:F309 2.39 2 Yes Yes 6 5 2 1
R:R:D99 R:R:Y313 3.45 2 Yes Yes 6 7 2 2
R:R:R102 R:R:W109 3 0 Yes Yes 5 7 1 2
R:R:Q120 R:R:R102 3.5 0 Yes Yes 4 5 1 1
R:R:E197 R:R:Y106 15.71 2 No No 4 3 1 1
R:R:F119 R:R:W109 4.01 2 Yes Yes 4 7 2 2
R:R:C198 R:R:W109 11.75 2 No Yes 9 7 2 2
R:R:F119 R:R:Q120 3.51 2 Yes Yes 4 4 2 1
R:R:Q120 R:R:V182 8.6 0 Yes No 4 4 1 2
R:R:C198 R:R:Q120 3.05 2 No Yes 9 4 2 1
L:L:?1 R:R:Q120 10.18 2 Yes Yes 0 4 0 1
R:R:A175 R:R:F121 2.77 2 Yes Yes 7 6 2 2
R:R:F121 R:R:I178 2.51 2 Yes No 6 4 2 1
R:R:E124 R:R:Y128 15.71 2 Yes Yes 4 6 1 1
R:R:A175 R:R:E124 3.02 2 Yes Yes 7 4 2 1
R:R:E124 R:R:I178 5.47 2 Yes No 4 4 1 1
R:R:E124 R:R:S217 2.87 2 Yes Yes 4 6 1 2
R:R:E124 R:R:R283 10.47 2 Yes Yes 4 6 1 1
L:L:?1 R:R:E124 10.14 2 Yes Yes 0 4 0 1
R:R:S174 R:R:Y128 8.9 2 No Yes 5 6 2 1
R:R:A175 R:R:Y128 2.67 2 Yes Yes 7 6 2 1
R:R:S217 R:R:Y128 7.63 2 Yes Yes 6 6 2 1
R:R:F220 R:R:Y128 11.35 2 Yes Yes 6 6 2 1
L:L:?1 R:R:Y128 2.24 2 Yes Yes 0 6 0 1
R:R:F220 R:R:S174 3.96 2 Yes No 6 5 2 2
L:L:?1 R:R:I178 9.56 2 Yes No 0 4 0 1
R:R:L181 R:R:M213 4.24 0 No No 4 5 2 1
R:R:E197 R:R:R199 5.82 2 No Yes 4 3 1 1
R:R:P200 R:R:R199 2.88 0 No Yes 4 3 2 1
R:R:F290 R:R:R199 3.21 2 Yes Yes 1 3 1 1
R:R:F286 R:R:P200 4.33 2 Yes No 4 4 1 2
R:R:F290 R:R:V205 11.8 2 Yes No 1 4 1 2
R:R:M213 R:R:S287 3.07 0 No No 5 4 1 2
L:L:?1 R:R:M213 5.41 2 Yes No 0 5 0 1
R:R:R283 R:R:S217 7.91 2 Yes Yes 6 6 1 2
R:R:F279 R:R:R283 12.83 2 Yes Yes 6 6 2 1
R:R:F279 R:R:S308 2.64 2 Yes No 6 7 2 2
L:L:?1 R:R:R283 13.94 2 Yes Yes 0 6 0 1
R:R:F286 R:R:F290 6.43 2 Yes Yes 4 1 1 1
R:R:F290 R:R:S289 3.96 2 Yes No 1 2 1 1
R:R:I297 R:R:S289 3.1 0 No No 1 2 2 1
R:R:A298 R:R:Q299 4.55 2 No No 3 1 1 1
R:R:Q299 R:R:Y303 2.25 2 No No 1 1 1 2
R:R:N305 R:R:S308 2.98 2 Yes No 4 7 1 2
R:R:F309 R:R:Y313 9.28 2 Yes Yes 5 7 1 2
R:R:C95 R:R:S123 1.72 0 No No 6 6 2 1
R:R:G282 R:R:N305 1.7 0 Yes Yes 4 4 2 1
L:L:L6 R:R:A298 1.58 2 Yes No 0 3 0 1
R:R:F38 R:R:P39 1.44 2 Yes No 4 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
57.69Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
56.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
56.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
56.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
52.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
52.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
51.72Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
51.72Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
51.72Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
51.72Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
51.72Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
51.72Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
50.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
48.39Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
48.39Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
48.39Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
48.39Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
48.28Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
48.28Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
48.15Single3OE0CVX153OE0-CXCR4-CVX15
48.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
48.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
47.83Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
46.43Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
46.43Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
46.15Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
46.15Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
44.83Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.83Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
44.83Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
44.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
43.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
43.33Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
43.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
43.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
43.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
43.33Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
42.86Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
42.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusangiotensin_onOrthosteric Ligandat1_on
42.86Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.86Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.86Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
42.86Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
42.31Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
42.31Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
41.67Single6OS1TRV0266OS1-AT1-TRV026
41.67Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
41.38Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.38Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
41.38Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
41.38Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.38Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
41.38Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.38Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
41.38Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
40.91Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.91Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.74Single7F8XNN90567F8X-CCKA-NN9056
40.74Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.74Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
40.74Single8XWNCXCL88XWN-CXCR2-CXCL8
40.74Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
40.74Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
40.62Single6IGLIRL16206IGL-ETB-IRL1620
40.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
40.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
40.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
40.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
40.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
40.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
40.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
40.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
40.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
40.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
40.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
40.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
40.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
40.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
39.39Single5GLHEndothelin-15GLH-ETB-Endothelin-1
39.39Single6IGKEndothelin-36IGK-ETB-Endothelin-3
39.39Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
39.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
39.29Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
39.29Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
39.29Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
39.29Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
39.29Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
39.13Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
39.13Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
39.13Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
38.71Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
38.71Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.71Single7SK3CXCL127SK3-ACKR3-CXCL12
38.71Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
38.46Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
38.46Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
38.46Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
38.46Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
38.46Consensuscck_onOrthosteric Ligandccka_on cckb_on
38.46Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
38.24Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
37.93Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
37.93Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
37.93Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
37.93Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.93Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.93Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
37.93Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
37.84Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
37.84Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
37.50Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
37.50Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
37.50Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
37.14Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
37.04Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
37.04Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
37.04Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Single8QJ2pN1628QJ2-MC4-pN162-Gs
37.04Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
36.67Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
36.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
36.67Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
36.67Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
36.67Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
36.36Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
36.36Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
36.36Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
36.36Single8IY6Endothelin-18IY6-ETB-Endothelin-1
36.36Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
36.36Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
36.36Consensusbradykinin_onOrthosteric Ligandbk2_on
36.36Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
36.36Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
36.36Consensusendothelin_onOrthosteric Ligandetb_on eta_on
36.36Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
36.36Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
36.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
36.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
36.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
36.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
36.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
36.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
36.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
36.00Consensusneurotensin_onOrthosteric Ligandnts1_on
36.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
35.71Single4XT1Fractalkine4XT1-US28-Fractalkine
35.71Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
35.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
35.71Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
35.71Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.71Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
35.71Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
35.71Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
35.71Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.71Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
35.71Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.71Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
35.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.48Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
35.48Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
35.48Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
35.48Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
35.48Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
35.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
35.48Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
35.29Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
34.78Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
34.62Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
34.62Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
34.62Single4XEENeurotensin4XEE-NTS1-Neurotensin
34.62Single4XESNeurotensin4XES-NTS1-Neurotensin
34.62Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
34.62Single6OS2TRV0266OS2-AT1-TRV026
34.62Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.62Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
34.62Single8XQJJN2418XQJ-Apelin-JN241
34.62Single8XWACXCL18XWA-CXCR2-CXCL1
34.62Single8XWMCXCL68XWM-CXCR2-CXCL6
34.62Single8XWSCXCL58XWS-CXCR2-CXCL5
34.62Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
34.62Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
34.62Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
34.62Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
34.62Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
34.62Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
34.62Consensusorexin_onOrthosteric Ligandox2_on
34.62Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
34.62Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
34.48Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
34.48Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
34.48Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
34.48Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
34.48Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
34.48Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
34.48Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
34.48Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
34.48Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
34.48Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
34.48Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.38Single4XT3Fractalkine4XT3-US28-Fractalkine
34.38Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
34.38Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
34.38Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
34.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
34.29Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
34.29Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
34.29Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
34.29Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
33.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
33.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
33.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
33.33Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
33.33Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
33.33Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
33.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
33.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
33.33Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
33.33Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
33.33Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XVUCXCL28XVU-CXCR2-CXCL2
33.33Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
33.33Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
33.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
33.33Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
33.33Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
33.33Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
33.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
33.33Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
33.33Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
32.56Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
32.35Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
32.35Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
32.35Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.35Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
32.26Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
32.26Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.26Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
32.26Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
32.26Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
32.14Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
32.14Single6KNMJN241-96KNM-Apelin-JN241-9
32.14Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
32.14Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
32.14Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
32.14Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
32.14Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
32.14Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
32.14Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
32.14Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
32.14Single8XQJJN2418XQJ-Apelin-JN241
32.14Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
32.14Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
32.14Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
32.14Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
32.14Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
32.14Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
32.14Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
32.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
32.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
32.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
32.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
32.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
32.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
31.82Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
31.82Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
31.82Consensusgq_nucleotideOrthosteric Ligandgq_p2y
31.82Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.43Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
31.25Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
31.25Single8ZRTET-18ZRT-ETB-ET-1
31.25Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
31.25Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.25Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.25Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
31.25Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
31.25Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.03Single4IARErgotamine4IAR-5-HT1B-Ergotamine
31.03Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
31.03Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
31.03Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
31.03Single8WKYPG-9348WKY-MC4-PG-934
31.03Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
31.03Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
31.03Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.03Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
31.03Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
31.03Consensuslpl_onOrthosteric Ligands1p_on lpa_on
31.03Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
31.03Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
31.03Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.03Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.03Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Single4BV0Neurotensin4BV0-NTS1-Neurotensin
30.77Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
30.77Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
30.77Single5XR8AM8415XR8-CB1-AM841
30.77Single5XRAAM115425XRA-CB1-AM11542
30.77Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
30.77Single7F1TMIP-1a7F1T-CCR5-MIP-1a
30.77Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
30.77Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
30.77Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
30.77Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
30.77Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
30.77Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
30.77Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
30.77Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
30.77Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
30.77Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
30.77Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
30.43Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
30.43Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.43Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
30.30Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.30Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
30.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
30.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.00Single7SK5CXCL127SK5-ACKR3-CXCL12
30.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
30.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
30.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
30.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
30.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
30.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
30.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
30.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
29.63Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
29.63Single4RWADIPP-NH24RWA-δ-DIPP-NH2
29.63Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
29.63Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
29.63Single6YVRNTS8-136YVR-NTS1-NTS8-13
29.63Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
29.63Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
29.63Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.63Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
29.63Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
29.63Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
29.63Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
29.63Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
29.63Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
29.63Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
29.63Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
29.63Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.63Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
29.63Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
29.63Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
29.63Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
29.63Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.63Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.63Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
29.63Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
29.63Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
29.63Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
29.63Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
29.63Consensuslpa_offOrthosteric Ligandlpa1_off
29.63Consensuslpl_offOrthosteric Ligands1p_off lpa_off
29.63Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
29.63Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
29.41Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.41Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
29.41Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
29.41Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
29.17Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
29.17Single6ZINSR486926ZIN-NTS1-SR48692
29.17Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
29.17Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
29.17Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
29.17Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
29.17Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.17Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
29.17Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
29.03Single5WF5UK-4320975WF5-A2A-UK-432097
29.03Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
29.03Single6W25SHU91196W25-MC4-SHU9119-Ca
29.03Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
29.03Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.03Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
29.03Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
29.03Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.03Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.03Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
29.03Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
28.57Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
28.57Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
28.57Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
28.57Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
28.57Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
28.57Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
28.57Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
28.57Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
28.57Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
28.57Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
28.57Single8XWFCXCL38XWF-CXCR2-CXCL3
28.57Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
28.57Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
28.57Consensuschemerin_onOrthosteric Ligandcml1_on
28.57Consensusp2y_offOrthosteric Ligandp2y1_off
28.57Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
28.57Consensusprostanoid_offOrthosteric Ligandep_off dp_off
28.12Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
28.12Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
28.12Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.12Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.12Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.12Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.00Single4QIMANTA XV4QIM-SMO-ANTA XV
28.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
28.00Single6D27CAY104716D27-DP2-CAY10471
28.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
28.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
28.00Single7V3ZCP559407V3Z-CB1-CP55940
28.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
28.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
28.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
28.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
28.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
28.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
27.78Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.78Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.78Consensusbombesin_onOrthosteric Ligandbb2_on
27.78Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
27.78Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.59Single5ZTYAM102575ZTY-CB2-AM10257
27.59Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
27.59Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
27.59Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
27.59Single7XN9L-054,5227XN9-SST2-L-054,522
27.59Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
27.59Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
27.59Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
27.59Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
27.59Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
27.59Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
27.27Single3OE6IT1t3OE6-CXCR4-IT1t
27.27Single4XNWMRS25004XNW-P2Y1-MRS2500
27.27Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
27.27Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
27.27Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
27.27Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
27.27Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
27.27Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
26.92Single5N2SPSB365N2S-A1-PSB36
26.92Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.92Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.92Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
26.92Single6Z4SSR486926Z4S-NTS1-SR48692
26.92Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
26.92Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
26.92Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.92Single7W41PD1762527W41-BB2-PD176252
26.92Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8S4DCMF-0198S4D-Apelin-CMF-019
26.92Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
26.92Consensusa3_on_gpOrthosteric Liganda3a_on_gp
26.92Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.92Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.92Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.92Consensusbombesin_offOrthosteric Ligandbb2_off
26.92Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.92Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.92Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
26.92Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
26.92Consensusdp_offOrthosteric Liganddp2_off
26.92Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.92Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.92Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
26.67Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
26.67Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
26.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
26.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
26.67Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
26.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.67Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.67Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
26.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
26.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
26.67Single8WDTphotoNECA8WDT-A2A-photoNECA
26.67Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.67Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.67Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.67Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.67Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
26.47Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.47Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
26.09Single3OE9IT1t3OE9-CXCR4-IT1t
26.09Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.93Single5TZRMK86665TZR-FFA1-MK8666
25.93Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
25.93Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
25.93Single7B6WCyclazosin7B6W-α1b-Cyclazosin
25.93Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.93Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
25.93Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
25.93Single7FEECP559407FEE-CB1-CP55940-ZCZ011
25.93Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
25.93Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
25.93Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
25.93Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
25.93Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
25.93Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
25.93Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
25.93Single8E0GBU728E0G-μ-BU72
25.93Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
25.93Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
25.93Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
25.93Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
25.93Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
25.93Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.93Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
25.93Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
25.93Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
25.93Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
25.93Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.93Consensuslpa_onOrthosteric Ligandlpa1_on
25.93Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
25.93Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.93Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.81Single3QAKUK-4320973QAK-A2A-UK-432097
25.81Single7XNACYN1548067XNA-SST2-CYN154806
25.81Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
25.81Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.81Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.81Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
25.81Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
25.81Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
25.71Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
25.00Single3ODUIT1t3ODU-CXCR4-IT1t
25.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
25.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
25.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
25.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
25.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
25.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
25.00Single8JJLOlodaterol8JJL-β2-Olodaterol
25.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
25.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
25.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.24Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
24.24Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.24Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.14Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
24.14Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
24.14Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
24.14Single7EZCUKA7EZC-A2A-UKA
24.14Single7UM4AS26747237UM4-5-HT5A-AS2674723
24.14Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
24.14Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
24.14Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
24.14Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
24.14Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.14Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
24.14Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
24.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
24.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
24.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
24.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
24.00Single7AROLUF58337ARO-A2A-LUF5833-Na
24.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
24.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
24.00Single8IHKAcifran8IHK-HCA3-Acifran
24.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
24.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
24.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
24.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
24.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
24.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
24.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
24.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
24.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
24.00Consensushca_onOrthosteric Ligandhca2_on
23.53Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.33Single4UG2CGS216804UG2-A2A-CGS21680
23.33Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
23.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
23.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
23.33Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskisspeptin_onOrthosteric Ligandkiss1_on
23.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.08Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
23.08Single4YAYZD-71554YAY-AT1-ZD-7155
23.08Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
23.08Single5T04Neurotensin5T04-NTS1-Neurotensin
23.08Single5UIGCmpd-15UIG-A2A-Cmpd-1
23.08Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
23.08Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.08Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
23.08Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
23.08Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
23.08Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
23.08Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
23.08Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
23.08Single8CU6LJ-45178CU6-A2A-LJ-4517
23.08Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
23.08Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
23.08Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
23.08Single8K5DGSK2560738K5D-HCA2-GSK256073
23.08Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
23.08Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
23.08Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
23.08Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
23.08Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
23.08Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
23.08Single9IYAONO-97105319IYA-GPR55-ONO-9710531
23.08Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
23.08Consensusa3_onOrthosteric Liganda3a_on
23.08Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
23.08Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
23.08Consensuscck_offOrthosteric Ligandccka_off
23.08Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.08Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
23.08Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
23.08Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
23.08Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
23.08Consensushca_on_gpOrthosteric Ligandhca2_on_gp
22.58Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
22.58Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
22.58Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
22.58Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
22.58Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
22.58Single8KIGSHU91198KIG-MC3-SHU9119-Ca
22.58Consensussomatostatin_offOrthosteric Ligandsst2_off
22.22Single4NTJAZD12834NTJ-P2Y12-AZD1283
22.22Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
22.22Single5C1MBU725C1M-μ-BU72
22.22Single5N2RPSB-365N2R-A2A-PSB-36-Na
22.22Single5XPRBosentan5XPR-ETB-Bosentan
22.22Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
22.22Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
22.22Single7C4SS1P7C4S-S1P3-S1P
22.22Single7C61Ergotamine7C61-5-HT1B-Ergotamine
22.22Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
22.22Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
22.22Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
22.22Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
22.22Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
22.22Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
22.22Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
22.22Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
22.22Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.22Single8QOTNanobody-E8QOT-μ-Nanobody-E
22.22Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
22.22Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
22.22Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
22.22Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
22.22Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
22.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.22Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.22Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.22Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.22Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.22Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.22Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
21.88Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
21.88Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.74Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.74Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.74Single8JPSCCL78JPS-ACKR1-CCL7
21.74Consensus5ht2_onOrthosteric Ligand5ht2b_on
21.74Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.62Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
21.43Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
21.43Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
21.43Single5V56TC1145V56-SMO-TC114
21.43Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
21.43Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.43Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
21.43Single6TQ7SB-3348676TQ7-OX1-SB-334867
21.43Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
21.43Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
21.43Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
21.43Single7R0CAVP7R0C-V2-AVP-Arrestin2
21.43Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
21.43Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.43Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
21.43Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
21.43Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
21.43Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.43Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
21.43Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
21.43Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
21.43Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
21.43Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
21.43Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single8XVLZibotentan8XVL-ETA-Zibotentan
21.43Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
21.43Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
21.43Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
21.43Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
21.43Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
21.43Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
21.43Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.43Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
21.43Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
21.43Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.43Consensusrelaxin_onOrthosteric Ligandrxfp4_on
21.43Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
21.21Single6PT2KGCHM076PT2-δ-KGCHM07
21.21Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
20.83Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.83Single7SRQLSD7SRQ-5-HT2B-LSD
20.83Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
20.83Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.83Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
20.83Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
20.83Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
20.83Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
20.83Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
20.69Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.69Single3D4STimolol3D4S-β2-Timolol
20.69Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
20.69Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
20.69Single6ZG4HTL00099366ZG4-M1-HTL0009936
20.69Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
20.69Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
20.69Single7YITNalfurafine7YIT-κ-Nalfurafine
20.69Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
20.69Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
20.69Single8JWY2-1188JWY-A2A-2-118
20.69Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
20.69Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
20.69Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
20.69Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
20.69Consensusalpha1_offOrthosteric Ligandalpha1a_off
20.69Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
20.69Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
20.59Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
20.59Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.59Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.59Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.59Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
20.59Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.59Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
20.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.00Single3PWHZM-2413853PWH-A2A-ZM-241385
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5WS3EMPA5WS3-OX2-EMPA
20.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
20.00Single6IBLArformoterol6IBL-β1-Arformoterol
20.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
20.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
20.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.00Single6TODEMPA6TOD-OX1-EMPA-Na
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
20.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
20.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
20.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
20.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
20.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
20.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
20.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
20.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
20.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
20.00Consensusendothelin_offOrthosteric Ligandetb_off
20.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
20.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
20.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
20.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
20.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
20.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.44Single6FJ3PTH6FJ3-PTH1-PTH
19.44Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
19.44Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
19.35Single3NY9ICI118-5513NY9-β2-ICI118-551
19.35Single5WF6UK-4320975WF6-A2A-UK-432097
19.35Single6PT3DPI-2876PT3-δ-DPI-287
19.35Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
19.35Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
19.35Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
19.35Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
19.23Single3REYXAC3REY-A2A-XAC
19.23Single4ZJCSB-6740424ZJC-OX1-SB-674042
19.23Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
19.23Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
19.23Single6IQLL7458706IQL-D4-L745870
19.23Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
19.23Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
19.23Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
19.23Single6TP3Nemorexant6TP3-OX1-Nemorexant
19.23Single6TPNHTL66416TPN-OX2-HTL6641
19.23Single6V9SGTPL114036V9S-OX1-GTPL11403
19.23Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
19.23Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
19.23Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
19.23Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single7UL3Famotidine7UL3-H2-Famotidine
19.23Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
19.23Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
19.23Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
19.23Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.23Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
19.23Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
19.23Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
19.23Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8K5CAcipimox8K5C-HCA2-Acipimox
19.23Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
19.23Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
19.23Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
19.23Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
19.23Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
19.23Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
19.23Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
19.23Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
19.23Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
19.23Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
19.23Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
19.23Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
19.23Consensusgrh_offOrthosteric Ligandgnrh1_off
19.23Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
18.92Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
18.92Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.75Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
18.75Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8IEBA1LYA8IEB-GPR156-A1LYA
18.75Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
18.52Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
18.52Single2Y02Carmoterol2Y02-β1-Carmoterol
18.52Single3EMLZM-2413853EML-A2A-ZM-241385
18.52Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.52Single4EJ4Naltrindole4EJ4-δ-Naltrindole
18.52Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
18.52Single5DHGC-355DHG-NOP-C-35
18.52Single5DHHSB-6121115DHH-NOP-SB-612111
18.52Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
18.52Single5TGZAM65385TGZ-CB1-AM6538
18.52Single5UENDU1725UEN-A1-DU172
18.52Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
18.52Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.52Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.52Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
18.52Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
18.52Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
18.52Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
18.52Single6PS1Timolol6PS1-β2-Timolol
18.52Single6S0LZM-2413856S0L-A2A-ZM-241385
18.52Single6TOTLemborexant6TOT-OX1-Lemborexant
18.52Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
18.52Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
18.52Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
18.52Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.52Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
18.52Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
18.52Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
18.52Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
18.52Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
18.52Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.52Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
18.52Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
18.52Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
18.52Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
18.52Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
18.52Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
18.52Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
18.52Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
18.52Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
18.52Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
18.52Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
18.52Single8RLNLUF58348RLN-A2A-LUF5834
18.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.52Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
18.52Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
18.52Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
18.52Single9CHXS-Carazolol9CHX-β2-S-Carazolol
18.52Consensus5ht5_onOrthosteric Ligand5ht5a_on
18.52Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.52Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
18.52Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
18.52Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
18.52Consensusalpha2_onOrthosteric Ligandalpha2b_on
18.52Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
18.52Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.52Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.52Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.52Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.52Consensusblt_onOrthosteric Ligandblt1_on
18.52Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
18.52Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
18.52Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.52Consensusleukotriene_onOrthosteric Ligandblt_on
18.52Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
18.52Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
18.42Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
18.42Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
18.18Single6HLOAprepitant6HLO-NK1-Aprepitant
18.18Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.18Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
18.18Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
18.18Single8IEBA1LYA8IEB-GPR156-A1LYA
17.95Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
17.86Single2YCWS-Carazolol2YCW-β1-S-Carazolol
17.86Single4JKVTaladegib4JKV-SMO-Taladegib
17.86Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
17.86Single5D6LS-Carazolol5D6L-β2-S-Carazolol
17.86Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.86Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
17.86Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
17.86Single5TVNLSD5TVN-5-HT2B-LSD
17.86Single5WQCEMPA5WQC-OX2-EMPA
17.86Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
17.86Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
17.86Single6PS6Timolol6PS6-β2-Timolol
17.86Single6S0QZM-2413856S0Q-A2A-ZM-241385
17.86Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
17.86Single6TP6Filorexant6TP6-OX1-Filorexant
17.86Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.86Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
17.86Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
17.86Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
17.86Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
17.86Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
17.86Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
17.86Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
17.86Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
17.86Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
17.86Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
17.86Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.86Single8JXSPF-61428JXS-D1-PF-6142
17.86Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
17.86Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
17.86Single8TF5Oleic acid8TF5-GPR6-Oleic acid
17.86Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
17.86Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
17.86Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
17.86Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
17.86Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.86Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
17.86Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
17.86Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
17.86Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
17.86Consensusadenosine_offOrthosteric Liganda1_off a2_off
17.86Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
17.86Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
17.86Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
17.86Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
17.86Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
17.65Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
17.65Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
17.65Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
17.50Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
17.39Single3OE8IT1t3OE8-CXCR4-IT1t
17.39Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.39Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.39Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.39Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.24Single2YDVNECA2YDV-A2A-NECA
17.24Single3P0GBI1671073P0G-β2-BI167107
17.24Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.24Single4DJHJDTic4DJH-κ-JDTic
17.24Single4UHRCGS216804UHR-A2A-CGS21680
17.24Single5D5AS-Carazolol5D5A-β2-S-Carazolol
17.24Single5D5BS-Carazolol5D5B-β2-S-Carazolol
17.24Single5G53NECA5G53-A2A-NECA-Gs
17.24Single5V57TC1145V57-SMO-TC114
17.24Single6E59L-7607356E59-NK1-L-760735
17.24Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.24Single6J20Aprepitant6J20-NK1-Aprepitant
17.24Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.24Single6WGTLSD6WGT-5-HT2A-LSD
17.24Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
17.24Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
17.24Single7PX4PSB-21137PX4-A2A-PSB-2113
17.24Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.24Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.24Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
17.24Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
17.24Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
17.24Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
17.24Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.24Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
17.24Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.24Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.24Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.24Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.24Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
17.24Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
17.24Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
17.24Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
17.24Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.24Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
17.24Consensusa2_onOrthosteric Liganda2b_on
17.24Consensusa2_on_gpOrthosteric Liganda2b_on_gp
17.24Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.24Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.24Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
17.24Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
17.24Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.24Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.24Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.24Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.24Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.24Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
17.24Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
17.24Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.24Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
17.24Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
17.24Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.24Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.24Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.14Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.14Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
17.14Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.14Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.14Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.14Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.14Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.14Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.14Consensusvasop-oxy_onOrthosteric Ligandv2_on
17.14Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
17.07Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.07Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single4AMIBucindolol4AMI-β1-Bucindolol
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
16.67Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
16.67Single6A93Risperidone6A93-5-HT2A-Risperidone
16.67Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
16.67Single7DFPSpiperone7DFP-D2-Spiperone
16.67Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7K15MKD0467K15-BLT1-MKD046-Na
16.67Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
16.67Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
16.67Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
16.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
16.67Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
16.67Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
16.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
16.67Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
16.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
16.67Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
16.67Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
16.67Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
16.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
16.67Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
16.67Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
16.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
16.67Single8JJ8Formoterol8JJ8-β2-Formoterol
16.67Single8JWZAB9288JWZ-A2A-AB928-Na
16.67Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.67Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.67Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
16.67Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
16.67Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
16.22Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
16.22Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
16.13Single5X93K-87945X93-ETB-K-8794
16.13Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.13Single6H7LDobutamine6H7L-β1-Dobutamine
16.13Single6K1QIRL25006K1Q-ETB-IRL2500
16.13Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
16.13Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
16.13Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
16.13Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
16.13Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
16.13Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
16.13Single8XVJMacitentan8XVJ-ETA-Macitentan
16.13Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.13Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.13Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.13Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
16.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.00Single5L7IVismodegib5L7I-SMO-Vismodegib
16.00Single6HLLCP999946HLL-NK1-CP99994
16.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
16.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
16.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
16.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
16.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
16.00Single8K5BNiacin8K5B-HCA2-Niacin
16.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.00Single9B9Y7DY9B9Y-CB1-7DY
16.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
16.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
16.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
16.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
15.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
15.79Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
15.79Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
15.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.62Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.62Single7SK9CCX6627SK9-ACKR3-CCX662
15.62Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
15.62Single8X5YAstemizole8X5Y-H1-Astemizole
15.38Single4QINSAG1.54QIN-SMO-SAG1.5
15.38Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
15.38Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.38Single5U09Taranabant5U09-CB1-Taranabant
15.38Single6AKXA4R6AKX-CCR5-A4R
15.38Single6B73MP11046B73-κ-MP1104
15.38Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
15.38Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.38Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.38Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
15.38Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
15.38Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.38Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
15.38Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
15.38Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
15.38Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
15.38Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.38Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.38Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.38Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.38Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.38Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
15.38Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
15.38Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.38Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.38Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
15.38Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
15.38Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.38Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
15.38Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
15.38Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
15.38Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
15.38Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
15.38Single8IWESpermidine8IWE-TA9-Spermidine
15.38Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
15.38Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.38Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.38Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.38Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.38Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
15.38Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.38Single9BA0A1AKN9BA0-CB1-A1AKN
15.38Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.38Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
15.38Consensusalpha2_offOrthosteric Ligandalpha2c_off
15.38Consensusangiotensin_offOrthosteric Ligandat1_off
15.38Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.38Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.38Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.38Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.15Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.15Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
15.15Single8IEIA1LYA8IEI-GPR156-A1LYA
15.15Single8IEPA1LYA8IEP-GPR156-A1LYA
15.15Single8IEPA1LYA8IEP-GPR156-A1LYA
15.15Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.15Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
15.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
14.81Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
14.81Single2YDOAdenosine2YDO-A2A-Adenosine
14.81Single3RZECidoxepin3RZE-H1-Cidoxepin
14.81Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
14.81Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
14.81Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
14.81Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.81Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
14.81Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
14.81Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.81Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
14.81Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.81Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.81Single5JTBZM-2413855JTB-A2A-ZM-241385
14.81Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
14.81Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
14.81Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
14.81Single5UVIZM-2413855UVI-A2A-ZM-241385
14.81Single6AQFZM-2413856AQF-A2A-ZM-241385
14.81Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.81Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
14.81Single6KUXRS-799486KUX-α2a-RS-79948
14.81Single6PS0S-Carazolol6PS0-β2-S-Carazolol
14.81Single6PS4ICI118-5516PS4-β2-ICI118-551
14.81Single6PS5S-Propranolol6PS5-β2-S-Propranolol
14.81Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
14.81Single6TPGEMPA6TPG-OX2-EMPA
14.81Single6TPKRetosiban6TPK-OT-Retosiban
14.81Single6VI4JDTic6VI4-κ-JDTic
14.81Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
14.81Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.81Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
14.81Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.81Single6ZG9GSK10347026ZG9-M1-GSK1034702
14.81Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
14.81Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
14.81Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
14.81Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
14.81Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
14.81Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
14.81Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
14.81Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single7T32ZM-2413857T32-A2A-ZM-241385
14.81Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
14.81Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
14.81Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
14.81Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
14.81Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
14.81Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
14.81Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
14.81Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
14.81Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
14.81Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
14.81Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
14.81Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
14.81Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.81Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
14.81Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
14.81Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
14.81Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
14.81Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
14.81Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.81Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
14.81Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
14.81Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
14.81Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
14.81Consensusa2_offOrthosteric Liganda2a_off
14.81Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.81Consensusalpha1_onOrthosteric Ligandalpha1a_on
14.81Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
14.81Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
14.81Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
14.81Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
14.81Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
14.81Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
14.81Consensusopsins_offOrthosteric Ligandrhodopsin_off
14.81Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.81Consensussensory_offOrthosteric Ligandopsins_off
14.81Consensusvasop-oxy_offOrthosteric Ligandot_off
14.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
14.71Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
14.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.63Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
14.63Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
14.63Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single2Y04Salbutamol2Y04-β1-Salbutamol
14.29Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
14.29Single3NY8ICI118-5513NY8-β2-ICI118-551
14.29Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
14.29Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
14.29Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
14.29Single4GBRS-Carazolol4GBR-β2-S-Carazolol
14.29Single4MQSIperoxo4MQS-M2-Iperoxo
14.29Single4QKX35V4QKX-β2-35V
14.29Single4U14Tiotropium4U14-M3-Tiotropium
14.29Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
14.29Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.29Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
14.29Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
14.29Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6GPSMK08126GPS-CCR2-MK0812
14.29Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
14.29Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
14.29Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
14.29Single7BU7BI1671077BU7-β1-BI167107
14.29Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
14.29Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.29Single7PYRPSB-21157PYR-A2A-PSB-2115
14.29Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
14.29Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
14.29Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
14.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.29Single7UL4Alvimopan7UL4-μ-Alvimopan
14.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
14.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
14.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
14.29Single7YXAONO-54306087YXA-S1P5-ONO-5430608
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
14.29Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
14.29Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
14.29Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
14.29Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
14.29Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
14.29Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
14.29Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
14.29Single8JJOAlprenolol8JJO-β2-Alprenolol
14.29Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.29Single8JXRLSD8JXR-D1-LSD
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.29Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
14.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
14.29Single8X63Mepyramine8X63-H1-Mepyramine
14.29Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
14.29Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
14.29Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
14.29Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.29Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.29Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
14.29Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
14.29Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
14.29Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
14.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
14.29Consensusdopamine_offOrthosteric Ligandd2_off d3_off
14.29Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
14.29Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
14.29Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
14.29Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.29Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.29Consensushistamine_offOrthosteric Ligandh1_off
14.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.29Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
13.89Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
13.89Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
13.89Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
13.89Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.79Single2RH1S-Carazolol2RH1-β2-S-Carazolol
13.79Single2Y00Dobutamine2Y00-β1-Dobutamine
13.79Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.79Single5JQHS-Carazolol5JQH-β2-S-Carazolol
13.79Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
13.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.79Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
13.79Single6E67BI1671076E67-β2-BI167107-Gs (fused)
13.79Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
13.79Single6GPXMK08126GPX-CCR2-MK0812
13.79Single6HLPNetupitant6HLP-NK1-Netupitant
13.79Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
13.79Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
13.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.79Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
13.79Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.79Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.79Single7SINNPS-21437SIN-CaS-NPS-2143
13.79Single7SINNPS-21437SIN-CaS-NPS-2143
13.79Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
13.79Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
13.79Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.79Single7WC6LSD7WC6-5-HT2A-LSD
13.79Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
13.79Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
13.79Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
13.79Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
13.79Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.79Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
13.79Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
13.79Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
13.79Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.79Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
13.79Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
13.79Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
13.79Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
13.79Consensusamine_offonOrthosteric Ligandamine_off amine_on
13.79Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
13.79Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
13.79Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
13.79Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
13.79Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
13.79Consensusblt_offOrthosteric Ligandblt1_off
13.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.79Consensusep_offOrthosteric Ligandep4_off
13.79Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.79Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.79Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
13.79Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.79Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Consensustrace-amine_onOrthosteric Ligandta1_on
13.64Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.64Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
13.64Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
13.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
13.33Single4U15Tiotropium4U15-M3-Tiotropium
13.33Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.33Single6J21Aprepitant6J21-NK1-Aprepitant
13.33Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.33Single6OL9Tiotropium6OL9-M5-Tiotropium
13.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
13.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.33Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
13.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
13.33Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.33Single9BJKNAM9BJK-μ-Naloxone-NAM
13.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
13.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
13.33Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
13.33Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.33Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
13.33Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.33Consensustachykinin_offOrthosteric Ligandnk1_off
13.16Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.16Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
13.16Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
13.16Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.16Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.16Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
13.04Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.04Single7WC4Serotonin7WC4-5-HT2A-Serotonin
13.04Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
13.04Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
13.04Single8PWNTheophylline8PWN-A2A-Theophylline
13.04Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.90Single4N4WSANT-14N4W-SMO-SANT-1
12.90Single5CXVTiotropium5CXV-M1-Tiotropium
12.90Single5X33BIIL2605X33-BLT1-BIIL260
12.90Single6CM4Risperidone6CM4-D2-Risperidone
12.90Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.90Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.90Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
12.90Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
12.90Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.90Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.90Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.90Single8XYIVUF106618XYI-CXCR3-VUF10661
12.90Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.90Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
12.82Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.82Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.82Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.82Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.82Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
12.82Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
12.50Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
12.50Single3RFMCaffeine3RFM-A2A-Caffeine
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
12.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.50Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
12.50Single9CHUNoradrenaline9CHU-β2-Noradrenaline
12.12Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.12Single8IEIA1LYA8IEI-GPR156-A1LYA
12.12Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
12.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
12.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
12.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
12.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
12.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
12.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
12.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
12.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
12.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.90Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.76Single7QA8Peptide7QA8-STE2-Peptide
11.76Single7QA8Peptide7QA8-STE2-Peptide
11.76Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.63Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.63Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.54Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.54Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.54Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
11.54Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.54Single3PBLEticlopride3PBL-D3-Eticlopride
11.54Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.54Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.54Single6LI0C176LI0-GPR52-C17
11.54Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.54Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.54Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.54Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.54Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.54Single7UL2SR486927UL2-NTS1-SR48692-Na
11.54Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.54Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
11.54Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
11.54Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
11.54Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
11.54Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
11.54Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
11.54Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.54Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.54Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
11.54Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.54Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
11.54Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
11.54Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
11.54Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
11.54Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
11.54Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.54Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
11.54Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
11.54Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.54Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.54Consensusneurotensin_offOrthosteric Ligandnts1_off
11.54Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.43Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.36Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.11Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.11Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.11Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.11Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
11.11Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.11Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
11.11Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.11Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
11.11Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
11.11Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
11.11Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
11.11Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
11.11Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
11.11Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
11.11Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
11.11Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
11.11Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
11.11Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
11.11Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
11.11Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
11.11Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
11.11Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
11.11Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
11.11Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
11.11Single8Y0HVUF114188Y0H-CXCR3-VUF11418
11.11Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
11.11Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
11.11Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.11Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
11.11Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
11.11Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
11.11Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
11.11Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
11.11Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
11.11Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.11Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
11.11Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
10.81Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
10.71Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.71Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.71Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.71Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.71Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
10.71Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
10.71Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
10.71Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
10.71Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
10.71Single7VV6C48/807VV6-MRGPRX2-C48/80
10.71Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.71Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.71Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.71Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
10.71Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
10.71Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
10.71Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
10.71Single8K2WAMG4878K2W-CXCR3-AMG487
10.71Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
10.71Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
10.71Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
10.71Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
10.71Single9BJKNaloxone9BJK-μ-Naloxone-NAM
10.71Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.71Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.53Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
10.53Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.53Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.34Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.34Single2Y01Dobutamine2Y01-β1-Dobutamine
10.34Single4DAJTiotropium4DAJ-M3-Tiotropium
10.34Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
10.34Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
10.34Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
10.34Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
10.34Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.34Single6H7MSalbutamol6H7M-β1-Salbutamol
10.34Single6IIVDaltroban6IIV-TP-Daltroban
10.34Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.34Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.34Single7WC7Lisuride7WC7-5-HT2A-Lisuride
10.34Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
10.34Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
10.34Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
10.34Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
10.34Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
10.34Single8T1WCVN4248T1W-GPR6-CVN424
10.34Single8X64Desloratadine8X64-H1-Desloratadine
10.34Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.34Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.34Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.34Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.34Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.26Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
10.26Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.26Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
10.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single5WIUNemonapride5WIU-D4-Nemonapride
10.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
10.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
10.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
10.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
10.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
10.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
10.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
10.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
10.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
9.76Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
9.76Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
9.68Single5V54Methiothepin5V54-5-HT1B-Methiothepin
9.68Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.68Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
9.68Single8EA0Iperoxo8EA0-M3-Iperoxo
9.68Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
9.68Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
9.68Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
9.68Consensus5ht1_offOrthosteric Ligand5ht1b_off
9.68Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
9.68Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
9.52Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
9.52Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.38Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.38Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
9.38Single6IIURamatroban6IIU-TP-Ramatroban
9.38Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
9.38Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
9.38Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.30Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
9.30Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
9.09Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
9.09Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
9.09Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
9.09Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
9.09Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.89Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
8.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.82Single5EE7MK08935EE7-Glucagon-MK0893
8.82Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
8.82Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.70Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.33Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.33Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.33Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.16Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
8.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
8.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
8.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
8.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
8.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.89Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.89Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
7.69Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.69Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
7.69Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69Single3UZAGTPL92363UZA-A2A-GTPL9236
7.69Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
7.69Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.69Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.69Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
7.69Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.69Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.69Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
7.69Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
7.69Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.69Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
7.69Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.69Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
7.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
7.41Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
7.41Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
7.41Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
7.41Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
7.41Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
7.41Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
7.41Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.41Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.41Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.41Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
7.32Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
7.14Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
7.14Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.90Single6A94Zotepine6A94-5-HT2A-Zotepine
6.90Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
6.90Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.90Single7VODCariprazine7VOD-5-HT2A-Cariprazine
6.90Single8IYXYL-3658IYX-GPR34-YL-365
6.90Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.90Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
6.90Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single5DSGTiotropium5DSG-M4-Tiotropium
6.67Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
6.67Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
6.67Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
6.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
6.45Single5CGCHTL142425CGC-mGlu5-HTL14242
6.45Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
6.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.45Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.45Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.45Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
6.25Single7P2L4YI7P2L-mGlu5-4YI
6.25Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.25Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.25Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
6.06Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.88Single5CGDHTL142425CGD-mGlu5-HTL14242
5.88Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
5.71Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
5.56Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.13Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single6D35Cholesterol6D35-SMO-Cholesterol
4.76Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.76Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.76Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.76Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.76Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.76Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.76Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.76Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.76Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.76Single7DTTCa7DTT-CaS-Ca-Ca
4.76Single7DTTCa7DTT-CaS-Ca-Ca
4.76Single7DTUTryptophan7DTU-CaS-Tryptophan
4.76Single7DTUTryptophan7DTU-CaS-Tryptophan
4.76Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.76Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.76Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.76Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.76Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.76Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.76Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.76Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.76Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.76Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.76Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.76Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.76Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.76Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.76Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.76Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.76Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.76Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.76Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
4.76Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.76Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.76Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.76Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.76Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.76Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.76Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.76Single7XW7K1-707XW7-TSH-K1-70
4.76Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.76Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.76Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.76Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.76Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.76Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.76Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.76Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.76Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.76Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.76Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.76Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.76Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.76Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.76Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.76Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.76Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.76Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.76Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.76Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.76Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.76Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.76Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.76Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.76Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.76Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.76Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.76Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.76Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.76Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.76Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.76Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.76Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.76Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.76Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.76Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.76Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.76Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.76Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.76Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.76Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.76Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.76Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.76Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.76Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.76Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8WVXNorrin8WVX-LGR4-Norrin
4.76Single8WVYNorrin8WVY-LGR4-Norrin
4.76Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.76Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.76Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.76Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.76Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.76Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.76Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.76Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.76Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.76Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.76Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.76Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.35Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.35Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.17Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.17Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.17Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.17Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.17Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.17Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
4.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
4.00Single5L7DCholesterol5L7D-SMO-Cholesterol
4.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.00Single8HS2Fab0468HS2-GPR20-Fab046
4.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.00Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.85Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.85Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
3.85Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
3.85Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
3.85Consensussensory_onOrthosteric Ligandopsins_on
3.70Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
3.70Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
3.70Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.70Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.70Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.70Consensusgi_sensoryOrthosteric Ligandgi_opsins
3.70Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.70Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.57Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
3.45Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.12Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.12Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.03Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
2.86Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.70Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.70Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.63Single7SHEPI; PE7SHE-GPR158-PI; PE
2.56Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.56Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.50Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.33Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 7F9Y
Class A
SubFamily Peptide
Type Ghrelin
SubType Ghrelin
Species Homo Sapiens
Ligand Ghrelin-28
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.9
Date 2021-08-18
D.O.I. 10.1038/s41467-021-25364-2
Net Summary
Imin 1.82
Number of Linked Nodes 873
Number of Links 1222
Number of Hubs 258
Number of Links mediated by Hubs 881
Number of Communities 18
Number of Nodes involved in Communities 378
Number of Links involved in Communities 615
Path Summary
Number Of Nodes in MetaPath 84
Number Of Links MetaPath 83
Number of Shortest Paths 6901929
Length Of Smallest Path 3
Average Path Length 33.3471
Length of Longest Path 52
Minimum Path Strength 1.37
Average Path Strength 6.0951
Maximum Path Strength 19.645
Minimum Path Correlation 0.7
Average Path Correlation 0.993942
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 33.8833
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 65.4281
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeOCA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeOCA
NameCaprylic acid
Synonymsn-octylic acid
Identifier
FormulaC8 H16 O2
Molecular Weight144.211
SMILES
PubChem379
Formal Charge0
Total Atoms26
Total Chiral Atoms0
Total Bonds25
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7F9Y_Chain_A
EDKAAVERS KMIEKQLQK DKQVYRRTL RLLLLGADN SGKSTIVKQ 
MRITSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ CFNDVTAII 
FVVDSSDNR LQEALNDFK SIWNNRWLR TISVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRKEFV 
DISTASGDG RHICYPHFT CSVDTENAR RIFNDCKDI ILQMNLREY 
NLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7F9Y_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7F9Y_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ92847
Sequence
>7F9Y_Chain_R
LQLFPAPLL AGVTATCVA LFVVGIAGN LLTMLVVSR FRELRTTTN 
LYLSSMAFS DLLIFLCMP LDLVRLWQY RPWNFGDLL CKLFQFVSE 
SCTYATVLT ITALSVERY FAICFPLRA KVVVTKGRV KLVIFVIWA 
VAFCSAGPI FVLVGVEHE NGTDPWDTN ECRPTEFAV RSGLLTVMV 
WVSSIFFFL PVFCLTVLY SLIGRKLWR NHKQTVKML AVVVFAFIL 
CWLPFHVGR YLFSKSFEP GSLEIAQIS QYCNLVSFV LFYLSAAIN 
PILYNIMSK KYRVAV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JSRAPeptideGhrelinGhrelinHomo sapiensAnamorelin-chim(NtGi1-Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1038/s41594-024-01481-6
8JSR (No Gprot) APeptideGhrelinGhrelinHomo sapiensAnamorelin-2.92025-01-22doi.org/10.1038/s41594-024-01481-6
7F83APeptideGhrelinGhrelinHomo sapiensPF-05190457--2.942022-01-1910.1038/s41467-022-27975-9
7W2ZAPeptideGhrelinGhrelinHomo sapiensGhrelin-Go/β1/γ22.82022-01-1910.1038/s41467-022-27975-9
7W2Z (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-2.82022-01-1910.1038/s41467-022-27975-9
7NA8APeptideGhrelinGhrelinHomo sapiensPubChem 178024-Gi1/β1/γ22.72021-12-1510.1038/s41467-021-26735-5
7NA8 (No Gprot) APeptideGhrelinGhrelinHomo sapiensPubChem 178024-2.72021-12-1510.1038/s41467-021-26735-5
7NA7APeptideGhrelinGhrelinHomo sapiensGhrelin-27-Gi1/β1/γ22.72021-12-1510.1038/s41467-021-26735-5
7NA7 (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-27-2.72021-12-1510.1038/s41467-021-26735-5
7F9ZAPeptideGhrelinGhrelinHomo sapiensGHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ23.22021-08-1810.1038/s41467-021-25364-2
7F9Z (No Gprot) APeptideGhrelinGhrelinHomo sapiensGHRP-6-3.22021-08-1810.1038/s41467-021-25364-2
7F9YAPeptideGhrelinGhrelinHomo sapiensGhrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ22.92021-08-1810.1038/s41467-021-25364-2
7F9Y (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-28-2.92021-08-1810.1038/s41467-021-25364-2
6KO5APeptideGhrelinGhrelinHomo sapiensPubChem 57400002--3.32020-08-1210.1038/s41467-020-17554-1




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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