psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R102	13.04	Yes	Yes	1	0	5
2	L:L:?1	R:R:L103	5.94	Yes	No	1	0	4
3	L:L:?1	R:R:Q120	11.43	Yes	Yes	1	0	4
4	L:L:?1	R:R:S123	7.52	Yes	No	0	0	6
5	L:L:?1	R:R:E124	5.69	Yes	Yes	1	0	4
6	L:L:?1	R:R:L181	3.96	Yes	Yes	1	0	4
7	L:L:?1	R:R:L210	2.97	Yes	No	1	0	3
8	L:L:?1	R:R:V214	3.2	Yes	No	0	0	5
9	L:L:?1	R:R:R283	12.17	Yes	Yes	1	0	6
10	L:L:?1	R:R:F286	19.18	Yes	No	0	0	4
11	L:L:?1	R:R:N305	8.85	Yes	No	0	0	4
12	L:L:?1	R:R:F309	6.1	Yes	Yes	1	0	5
13	R:R:L37	R:R:Y106	4.69	No	No	0	5	3
14	R:R:L37	R:R:Q302	3.99	No	No	0	5	3
15	R:R:F38	R:R:Q302	4.68	Yes	No	0	4	3
16	R:R:F38	R:R:Y303	13.41	Yes	No	0	4	1
17	R:R:F38	R:R:L306	7.31	Yes	No	0	4	4
18	R:R:L43	R:R:W104	13.67	No	No	0	5	4
19	R:R:L306	R:R:V46	2.98	No	No	0	4	4
20	R:R:C50	R:R:L100	6.35	No	Yes	0	6	7
21	R:R:L314	R:R:L53	4.15	No	No	0	5	7
22	R:R:A317	R:R:L53	3.15	No	No	0	7	7
23	R:R:F54	R:R:F93	7.5	No	Yes	0	7	6
24	R:R:F54	R:R:M96	7.46	No	Yes	0	7	7
25	R:R:F93	R:R:G57	4.52	Yes	No	0	6	8
26	R:R:I58	R:R:L62	5.71	No	No	5	6	3
27	R:R:I58	R:R:L90	4.28	No	No	5	6	7
28	R:R:A86	R:R:N61	4.69	No	Yes	0	9	9
29	R:R:D89	R:R:N61	6.73	Yes	Yes	0	9	9
30	R:R:L90	R:R:N61	4.12	No	Yes	0	7	9
31	R:R:N61	R:R:P320	3.26	Yes	No	0	9	9
32	R:R:L62	R:R:L90	4.15	No	No	5	3	7
33	R:R:L63	R:R:Y330	5.86	No	Yes	3	6	8
34	R:R:L63	R:R:V334	7.45	No	No	3	6	6
35	R:R:N324	R:R:T64	5.85	No	No	3	7	9
36	R:R:T64	R:R:Y330	3.75	No	Yes	3	9	8
37	R:R:V67	R:R:Y330	5.05	No	Yes	0	8	8
38	R:R:N79	R:R:V68	5.91	No	No	0	8	7
39	R:R:S83	R:R:V68	4.85	No	No	0	6	7
40	R:R:F71	R:R:R70	7.48	Yes	No	0	5	5
41	R:R:F71	R:R:L74	4.87	Yes	Yes	6	5	8
42	R:R:A333	R:R:F71	4.16	No	Yes	6	6	5
43	R:R:F71	R:R:R336	6.41	Yes	No	0	5	3
44	R:R:E73	R:R:L74	3.98	No	Yes	0	6	8
45	R:R:A333	R:R:L74	3.15	No	Yes	6	6	8
46	R:R:T76	R:R:T78	3.14	No	No	0	7	8
47	R:R:N79	R:R:T76	10.24	No	No	0	8	7
48	R:R:E140	R:R:T77	5.64	No	No	0	9	7
49	R:R:K157	R:R:T77	4.5	No	No	0	3	7
50	R:R:T77	R:R:V160	7.93	No	No	0	7	7
51	R:R:L80	R:R:V160	2.98	No	No	0	5	7
52	R:R:A136	R:R:Y81	4	No	Yes	0	7	8
53	R:R:L137	R:R:Y81	8.21	No	Yes	0	8	8
54	R:R:E140	R:R:Y81	4.49	No	Yes	0	9	8
55	R:R:V160	R:R:Y81	6.31	No	Yes	0	7	8
56	R:R:V163	R:R:Y81	6.31	No	Yes	0	6	8
57	R:R:I164	R:R:Y81	4.84	No	Yes	0	7	8
58	R:R:L82	R:R:M85	4.24	No	No	0	8	9
59	R:R:L82	R:R:N324	6.87	No	No	0	8	7
60	R:R:S84	R:R:T133	3.2	No	No	0	9	8
61	R:R:S84	R:R:W168	6.18	No	No	0	9	9
62	R:R:M85	R:R:T133	9.03	No	No	0	9	8
63	R:R:F87	R:R:L91	10.96	No	No	0	6	7
64	R:R:C126	R:R:S88	5.16	No	No	0	8	8
65	R:R:S88	R:R:T130	4.8	No	No	0	8	9
66	R:R:D89	R:R:T130	4.34	Yes	No	0	9	9
67	R:R:A316	R:R:D89	6.18	No	Yes	0	9	9
68	R:R:D89	R:R:N319	4.04	Yes	No	0	9	9
69	R:R:C126	R:R:L91	4.76	No	No	0	8	7
70	R:R:C126	R:R:I92	3.27	No	No	0	8	7
71	R:R:I92	R:R:T127	3.04	No	No	0	7	7
72	R:R:F312	R:R:I92	5.02	Yes	No	0	7	7
73	R:R:F93	R:R:Y313	3.09	Yes	Yes	0	6	7
74	R:R:A316	R:R:F93	4.16	No	Yes	0	9	6
75	R:R:C95	R:R:F119	6.98	No	Yes	0	6	4
76	R:R:C95	R:R:V122	3.42	No	No	0	6	5
77	R:R:M96	R:R:P97	3.35	Yes	No	0	7	7
78	R:R:L100	R:R:M96	5.65	Yes	Yes	0	7	7
79	R:R:M96	R:R:Y313	7.18	Yes	Yes	0	7	7
80	R:R:L98	R:R:W109	7.97	No	Yes	0	5	7
81	R:R:F119	R:R:L98	15.83	Yes	No	0	4	5
82	R:R:D99	R:R:R102	8.34	Yes	Yes	1	6	5
83	R:R:D99	R:R:F119	10.75	Yes	Yes	1	6	4
84	R:R:D99	R:R:F309	4.78	Yes	Yes	1	6	5
85	R:R:D99	R:R:Y313	5.75	Yes	Yes	1	6	7
86	R:R:F309	R:R:L100	3.65	Yes	Yes	0	5	7
87	R:R:R107	R:R:V101	6.54	No	No	0	4	4
88	R:R:F119	R:R:R102	6.41	Yes	Yes	1	4	5
89	R:R:Q120	R:R:R102	8.18	Yes	Yes	1	4	5
90	R:R:C198	R:R:R102	4.18	Yes	Yes	1	9	5
91	R:R:F309	R:R:L103	4.87	Yes	No	1	5	4
92	R:R:Q105	R:R:R107	7.01	No	No	0	4	4
93	R:R:P108	R:R:R107	5.76	No	No	0	4	4
94	R:R:N110	R:R:P108	8.15	No	No	0	3	4
95	R:R:N196	R:R:P108	3.26	Yes	No	0	4	4
96	R:R:F111	R:R:W109	3.01	No	Yes	0	6	7
97	R:R:C116	R:R:W109	7.84	Yes	Yes	1	9	7
98	R:R:V184	R:R:W109	7.36	Yes	Yes	1	5	7
99	R:R:C198	R:R:W109	11.75	Yes	Yes	1	9	7
100	R:R:N110	R:R:W193	3.39	No	No	0	3	4
101	R:R:F111	R:R:L115	3.65	No	No	0	6	5
102	R:R:D113	R:R:K117	11.06	No	No	0	4	7
103	R:R:D113	R:R:V184	8.76	No	Yes	0	4	5
104	R:R:L114	R:R:L118	5.54	No	No	0	4	5
105	R:R:C116	R:R:V184	3.42	Yes	Yes	1	9	5
106	R:R:C116	R:R:C198	7.28	Yes	Yes	1	9	9
107	R:R:F179	R:R:K117	4.96	No	No	0	5	7
108	R:R:F119	R:R:Q120	4.68	Yes	Yes	1	4	4
109	R:R:I178	R:R:Q120	4.12	No	Yes	1	4	4
110	R:R:Q120	R:R:V182	8.6	Yes	No	1	4	4
111	R:R:C198	R:R:Q120	3.05	Yes	Yes	1	9	4
112	R:R:F121	R:R:S125	7.93	Yes	No	1	6	5
113	R:R:F121	R:R:F172	4.29	Yes	No	1	6	4
114	R:R:F121	R:R:G176	3.01	Yes	No	0	6	4
115	R:R:F121	R:R:I178	3.77	Yes	No	1	6	4
116	R:R:F121	R:R:F179	16.08	Yes	No	0	6	5
117	R:R:E124	R:R:Y128	15.71	Yes	Yes	1	4	6
118	R:R:A175	R:R:E124	3.02	No	Yes	0	7	4
119	R:R:E124	R:R:R283	10.47	Yes	Yes	1	4	6
120	R:R:F172	R:R:S125	5.28	No	No	1	4	5
121	R:R:A175	R:R:S125	3.42	No	No	0	7	5
122	R:R:T127	R:R:Y128	3.75	No	Yes	0	7	6
123	R:R:S174	R:R:Y128	7.63	No	Yes	1	5	6
124	R:R:S217	R:R:Y128	3.82	No	Yes	0	6	6
125	R:R:F220	R:R:Y128	21.66	Yes	Yes	1	6	6
126	R:R:A129	R:R:W168	7.78	No	No	0	6	9
127	R:R:V131	R:R:W276	3.68	No	Yes	0	8	8
128	R:R:I167	R:R:L132	5.71	No	No	0	7	6
129	R:R:L132	R:R:V170	2.98	No	No	0	6	4
130	R:R:F220	R:R:L132	3.65	Yes	No	0	6	6
131	R:R:I167	R:R:T133	3.04	No	No	0	7	8
132	R:R:I134	R:R:L228	4.28	Yes	No	1	8	8
133	R:R:F272	R:R:I134	5.02	Yes	Yes	1	9	8
134	R:R:I134	R:R:N319	4.25	Yes	No	1	8	9
135	R:R:I134	R:R:Y323	6.04	Yes	No	1	8	9
136	R:R:P224	R:R:T135	3.5	No	No	0	9	7
137	R:R:C227	R:R:T135	3.38	No	No	0	6	7
138	R:R:L228	R:R:S138	6.01	No	No	0	8	9
139	R:R:L231	R:R:S138	4.5	Yes	No	0	7	9
140	R:R:S138	R:R:Y232	7.63	No	Yes	0	9	9
141	R:R:L231	R:R:V139	2.98	Yes	No	0	7	7
142	R:R:R141	R:R:Y232	8.23	No	Yes	0	9	9
143	R:R:R141	R:R:Y323	4.12	No	No	0	9	9
144	R:R:F143	R:R:Y142	4.13	No	Yes	0	5	8
145	R:R:C146	R:R:Y142	8.06	No	Yes	2	7	8
146	R:R:F147	R:R:Y142	3.09	Yes	Yes	2	6	8
147	R:R:L231	R:R:Y142	12.89	Yes	Yes	0	7	8
148	R:R:L234	R:R:Y142	7.03	No	Yes	0	5	8
149	R:R:I235	R:R:Y142	3.63	Yes	Yes	2	8	8
150	R:R:C146	R:R:F147	4.19	No	Yes	2	7	6
151	R:R:C146	R:R:K238	4.85	No	No	0	7	5
152	R:R:F147	R:R:R150	10.69	Yes	No	0	6	5
153	R:R:V153	R:R:V154	3.21	No	No	0	4	4
154	R:R:F172	R:R:W168	7.02	No	No	0	4	9
155	R:R:F220	R:R:S174	6.61	Yes	No	1	6	5
156	R:R:G176	R:R:P177	4.06	No	No	0	4	7
157	R:R:M213	R:R:P177	6.71	No	No	0	5	7
158	R:R:I178	R:R:V182	4.61	No	No	1	4	4
159	R:R:A204	R:R:L181	3.15	No	Yes	1	4	4
160	R:R:L181	R:R:L209	5.54	Yes	Yes	1	4	4
161	R:R:L181	R:R:L210	4.15	Yes	No	1	4	3
162	R:R:N196	R:R:V184	2.96	Yes	Yes	0	4	5
163	R:R:E185	R:R:R199	13.96	No	No	0	1	3
164	R:R:E185	R:R:E202	7.61	No	No	0	1	6
165	R:R:E187	R:R:H186	3.69	No	No	0	3	2
166	R:R:H186	R:R:N196	3.83	No	Yes	0	2	4
167	R:R:N196	R:R:W193	5.65	Yes	No	0	4	4
168	R:R:E197	R:R:R199	3.49	No	No	0	4	3
169	R:R:F286	R:R:P200	4.33	No	No	0	4	4
170	R:R:A204	R:R:T201	3.36	No	No	0	4	3
171	R:R:F203	R:R:S207	5.28	No	No	0	6	3
172	R:R:A204	R:R:L209	3.15	No	Yes	1	4	4
173	R:R:F290	R:R:V205	10.49	No	No	0	1	4
174	R:R:L209	R:R:V212	4.47	Yes	No	0	4	6
175	R:R:L210	R:R:S287	6.01	No	No	0	3	4
176	R:R:S287	R:R:V214	3.23	No	No	0	4	5
177	R:R:S218	R:R:W215	6.18	No	No	0	4	4
178	R:R:R283	R:R:S217	3.95	Yes	No	0	6	6
179	R:R:F221	R:R:F222	4.29	No	No	0	8	4
180	R:R:F221	R:R:L277	7.31	No	No	0	8	6
181	R:R:F221	R:R:H280	10.18	No	No	0	8	7
182	R:R:L223	R:R:P224	3.28	No	No	0	5	9
183	R:R:C227	R:R:L223	3.17	No	No	0	6	5
184	R:R:I273	R:R:V225	3.07	No	No	0	6	6
185	R:R:F226	R:R:V230	7.87	No	No	0	3	4
186	R:R:F272	R:R:L228	4.87	Yes	No	1	9	8
187	R:R:L265	R:R:Y232	14.07	No	Yes	0	8	9
188	R:R:V269	R:R:Y232	5.05	No	Yes	0	8	9
189	R:R:G236	R:R:V262	3.68	No	No	0	5	7
190	R:R:H258	R:R:L239	12.86	No	Yes	0	6	8
191	R:R:K259	R:R:W240	8.12	No	No	0	5	4
192	R:R:H258	R:R:N257	7.65	No	No	0	6	5
193	R:R:M264	R:R:V267	3.04	No	No	0	8	6
194	R:R:M264	R:R:V268	3.04	No	No	0	8	8
195	R:R:L322	R:R:V268	2.98	No	No	0	8	8
196	R:R:I273	R:R:V269	3.07	No	No	0	6	8
197	R:R:F270	R:R:L274	8.53	No	No	0	5	5
198	R:R:F272	R:R:W276	15.03	Yes	Yes	1	9	8
199	R:R:C275	R:R:L311	3.17	No	No	0	9	7
200	R:R:C275	R:R:S315	5.16	No	No	0	9	9
201	R:R:F279	R:R:W276	6.01	Yes	Yes	1	6	8
202	R:R:F312	R:R:W276	3.01	Yes	Yes	1	7	8
203	R:R:S315	R:R:W276	7.41	No	Yes	0	9	8
204	R:R:L277	R:R:P278	3.28	No	No	0	6	9
205	R:R:L311	R:R:P278	3.28	No	No	0	7	9
206	R:R:F279	R:R:H280	6.79	Yes	No	0	6	7
207	R:R:F279	R:R:R283	16.03	Yes	Yes	1	6	6
208	R:R:F279	R:R:F312	5.36	Yes	Yes	1	6	7
209	R:R:G282	R:R:L285	3.42	Yes	Yes	4	4	4
210	R:R:C304	R:R:G282	3.92	No	Yes	4	5	4
211	R:R:G282	R:R:N305	3.39	Yes	No	0	4	4
212	R:R:L285	R:R:S301	3	Yes	No	0	4	4
213	R:R:C304	R:R:L285	3.17	No	Yes	4	5	4
214	R:R:F286	R:R:F290	8.57	No	No	0	4	1
215	R:R:S289	R:R:S301	3.26	No	No	0	2	4
216	R:R:E291	R:R:P292	11	No	No	0	1	2
217	R:R:E291	R:R:S294	4.31	No	No	0	1	6
218	R:R:I297	R:R:S294	4.64	No	No	0	1	6
219	R:R:I297	R:R:I300	5.89	No	No	4	1	2
220	R:R:N305	R:R:S301	4.47	No	No	0	4	4
221	R:R:F309	R:R:Y313	16.5	Yes	Yes	1	5	7
222	R:R:F312	R:R:Y313	11.35	Yes	Yes	1	7	7
223	R:R:I318	R:R:I321	4.42	Yes	No	7	7	6
224	R:R:N319	R:R:Y323	3.49	No	No	1	9	9
225	R:R:N324	R:R:Y330	6.98	No	Yes	3	7	8
226	R:R:K328	R:R:V332	3.04	No	No	0	5	4
227	R:R:V334	R:R:Y330	7.57	No	Yes	3	6	8
228	R:R:L100	R:R:T47	2.95	Yes	No	0	7	6
229	R:R:L82	R:R:T78	2.95	No	No	0	8	8
230	R:R:L137	R:R:T78	2.95	No	No	0	8	8
231	R:R:L239	R:R:T261	2.95	Yes	No	0	8	8
232	R:R:I325	R:R:M326	2.92	No	No	0	6	7
233	R:R:F272	R:R:P224	2.89	Yes	No	0	9	9
234	R:R:M264	R:R:M326	2.89	No	No	0	8	7
235	R:R:P200	R:R:R199	2.88	No	No	0	4	3
236	R:R:I318	R:R:L314	2.85	Yes	No	0	7	5
237	R:R:I318	R:R:L322	2.85	Yes	No	7	7	8
238	R:R:I321	R:R:L322	2.85	No	No	7	6	8
239	R:R:G112	R:R:W109	2.81	No	Yes	0	8	7
240	R:R:L311	R:R:L314	2.77	No	No	0	7	5
241	R:R:F279	R:R:S308	2.64	Yes	No	0	6	7
242	R:R:F71	R:R:V67	2.62	Yes	No	0	5	8
243	R:R:E296	R:R:Q299	2.55	No	No	0	2	1
244	R:R:S327	R:R:Y330	2.54	No	Yes	0	8	8
245	R:R:F165	R:R:K161	2.48	No	No	0	4	3
246	R:R:K328	R:R:R331	2.48	No	No	0	5	8
247	R:R:F38	R:R:L42	2.44	Yes	No	0	4	3
248	R:R:F38	R:R:L43	2.44	Yes	No	0	4	5
249	R:R:F71	R:R:L337	2.44	Yes	No	0	5	5
250	R:R:F179	R:R:L118	2.44	No	No	0	5	5
251	R:R:L149	R:R:R150	2.43	No	No	0	7	5
252	R:R:L234	R:R:R237	2.43	No	No	0	5	4
253	R:R:E202	R:R:R206	2.33	No	No	0	6	1
254	R:R:Q105	R:R:W104	2.19	No	No	0	4	4
255	R:R:R72	R:R:R75	2.13	No	No	0	6	7
256	R:R:C116	R:R:G183	1.96	Yes	No	0	9	4
257	R:R:P39	R:R:P41	1.95	No	No	0	4	2
258	R:R:A44	R:R:G45	1.95	No	No	0	4	6
259	R:R:A48	R:R:G45	1.95	No	No	0	5	6
260	R:R:A59	R:R:G60	1.95	No	No	0	3	8
261	R:R:A40	R:R:P41	1.87	No	No	0	2	2
262	R:R:G208	R:R:S207	1.86	No	No	0	2	3
263	R:R:G57	R:R:V56	1.84	No	No	0	8	6
264	R:R:G282	R:R:V281	1.84	Yes	No	0	4	7
265	R:R:A129	R:R:A171	1.79	No	No	0	6	8
266	R:R:A144	R:R:A151	1.79	No	No	0	8	6
267	R:R:G236	R:R:I235	1.76	No	Yes	0	5	8
268	R:R:G293	R:R:L295	1.71	No	No	0	2	7
269	R:R:A151	R:R:V155	1.7	No	No	0	6	7
270	R:R:E291	R:R:G293	1.64	No	No	0	1	2
271	R:R:A271	R:R:I318	1.62	No	Yes	0	6	7
272	R:R:S308	R:R:V307	1.62	No	No	0	7	5
273	R:R:A86	R:R:M65	1.61	No	No	0	9	7
274	R:R:V310	R:R:V46	1.6	No	No	0	5	4
275	R:R:V166	R:R:V170	1.6	No	No	0	4	4
276	R:R:S287	R:R:T211	1.6	No	No	0	4	4
277	R:R:T47	R:R:V51	1.59	No	No	0	6	4
278	R:R:T229	R:R:V225	1.59	No	No	0	5	6
279	R:R:T229	R:R:V269	1.59	No	No	0	5	8
280	R:R:K152	R:R:V153	1.52	No	No	0	4	4
281	R:R:A298	R:R:Q299	1.52	No	No	0	3	1
282	R:R:A298	R:R:Q302	1.52	No	No	0	3	3
283	R:R:L209	R:R:S207	1.5	Yes	No	0	4	3
284	R:R:L234	R:R:S233	1.5	No	No	0	5	4
285	R:R:L162	R:R:V166	1.49	No	No	0	3	4
286	R:R:L209	R:R:V180	1.49	Yes	No	0	4	4
287	R:R:L231	R:R:V230	1.49	Yes	No	0	7	4
288	R:R:I145	R:R:I235	1.47	No	Yes	2	9	8
289	R:R:I164	R:R:K161	1.45	No	No	0	7	3
290	R:R:D194	R:R:T195	1.45	No	No	0	5	3
291	R:R:F38	R:R:P39	1.44	Yes	No	0	4	4
292	R:R:F147	R:R:P148	1.44	Yes	No	0	6	8
293	R:R:E140	R:R:V155	1.43	No	No	0	9	7
294	R:R:I145	R:R:L239	1.43	No	Yes	2	9	8
295	R:R:I235	R:R:L239	1.43	Yes	Yes	2	8	8
296	R:R:I297	R:R:L285	1.43	No	Yes	4	1	4
297	R:R:I300	R:R:L285	1.43	No	Yes	4	2	4
298	R:R:K329	R:R:L74	1.41	No	Yes	0	6	8
299	R:R:K152	R:R:L149	1.41	No	No	0	4	7
300	R:R:R70	R:R:S69	1.32	No	No	0	5	3
301	R:R:F54	R:R:V55	1.31	No	No	0	7	5
302	R:R:R159	R:R:V155	1.31	No	No	0	5	7
303	R:R:R159	R:R:V163	1.31	No	No	0	5	6
304	R:R:F220	R:R:V216	1.31	Yes	No	0	6	5
305	R:R:R159	R:R:T156	1.29	No	No	0	5	7
306	R:R:D194	R:R:H186	1.26	No	No	0	5	2
307	R:R:K288	R:R:Y284	1.19	No	No	0	4	5
308	R:R:W215	R:R:Y284	0.96	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.3375	12	1	0
2	R:R:F38	5.28667	6	0	4
3	R:R:N61	4.7	4	0	9
4	R:R:F71	4.66333	6	6	5
5	R:R:L74	3.3525	4	6	8
6	R:R:Y81	5.69333	6	0	8
7	R:R:D89	5.3225	4	0	9
8	R:R:F93	4.8175	4	0	6
9	R:R:M96	5.91	4	0	7
10	R:R:D99	7.405	4	1	6
11	R:R:L100	4.65	4	0	7
12	R:R:R102	8.03	5	1	5
13	R:R:W109	6.79	6	1	7
14	R:R:C116	5.125	4	1	9
15	R:R:F119	8.93	5	1	4
16	R:R:Q120	6.67667	6	1	4
17	R:R:F121	7.016	5	1	6
18	R:R:E124	8.7225	4	1	4
19	R:R:Y128	10.514	5	1	6
20	R:R:I134	4.8975	4	1	8
21	R:R:Y142	6.47167	6	2	8
22	R:R:F147	4.8525	4	2	6
23	R:R:L181	4.2	4	1	4
24	R:R:V184	5.625	4	1	5
25	R:R:N196	3.925	4	0	4
26	R:R:C198	6.565	4	1	9
27	R:R:L209	3.23	5	1	4
28	R:R:F220	8.3075	4	1	6
29	R:R:L231	5.465	4	0	7
30	R:R:Y232	8.745	4	0	9
31	R:R:I235	2.0725	4	2	8
32	R:R:L239	4.6675	4	2	8
33	R:R:F272	6.9525	4	1	9
34	R:R:W276	7.028	5	1	8
35	R:R:F279	7.366	5	1	6
36	R:R:G282	3.1425	4	4	4
37	R:R:R283	10.655	4	1	6
38	R:R:L285	2.49	5	4	4
39	R:R:F309	7.18	5	1	5
40	R:R:F312	6.185	4	1	7
41	R:R:Y313	8.774	5	1	7
42	R:R:I318	2.935	4	7	7
43	R:R:Y330	5.29167	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R102	37.4857	13.04	Yes	Yes	1	0	5
2	R:R:C198	R:R:R102	60.9481	4.18	Yes	Yes	1	9	5
3	R:R:C198	R:R:W109	50.362	11.75	Yes	Yes	1	9	7
4	R:R:V184	R:R:W109	56.1619	7.36	Yes	Yes	1	5	7
5	R:R:N196	R:R:V184	100	2.96	Yes	Yes	0	4	5
6	R:R:N196	R:R:P108	76.0384	3.26	Yes	No	0	4	4
7	R:R:P108	R:R:R107	69.2363	5.76	No	No	0	4	4
8	R:R:Q105	R:R:R107	62.3161	7.01	No	No	0	4	4
9	R:R:Q105	R:R:W104	58.8446	2.19	No	No	0	4	4
10	R:R:L43	R:R:W104	55.3654	13.67	No	No	0	5	4
11	R:R:F38	R:R:L43	51.8787	2.44	Yes	No	0	4	5
12	R:R:F38	R:R:Q302	21.0197	4.68	Yes	No	0	4	3
13	L:L:?1	R:R:Q120	44.4593	11.43	Yes	Yes	1	0	4
14	R:R:C198	R:R:Q120	37.6801	3.05	Yes	Yes	1	9	4
15	R:R:C116	R:R:C198	47.142	7.28	Yes	Yes	1	9	9
16	R:R:C116	R:R:V184	44.1011	3.42	Yes	Yes	1	9	5
17	R:R:F38	R:R:L306	10.3346	7.31	Yes	No	0	4	4
18	L:L:?1	R:R:R283	55.1406	12.17	Yes	Yes	1	0	6
19	R:R:F279	R:R:R283	85.8547	16.03	Yes	Yes	1	6	6
20	R:R:F279	R:R:W276	75.8936	6.01	Yes	Yes	1	6	8
21	R:R:S315	R:R:W276	32.5128	7.41	No	Yes	0	9	8
22	R:R:C275	R:R:S315	30.3864	5.16	No	No	0	9	9
23	R:R:C275	R:R:L311	28.2677	3.17	No	No	0	9	7
24	R:R:L311	R:R:L314	25.9965	2.77	No	No	0	7	5
25	L:L:?1	R:R:F309	16.2602	6.1	Yes	Yes	1	0	5
26	R:R:F309	R:R:Y313	11.2758	16.5	Yes	Yes	1	5	7
27	R:R:F93	R:R:Y313	18.8515	3.09	Yes	Yes	0	6	7
28	R:R:A316	R:R:F93	12.48	4.16	No	Yes	0	9	6
29	R:R:A316	R:R:D89	11.2606	6.18	No	Yes	0	9	9
30	R:R:D89	R:R:N61	10.346	6.73	Yes	Yes	0	9	9
31	L:L:?1	R:R:E124	23.893	5.69	Yes	Yes	1	0	4
32	R:R:E124	R:R:Y128	35.3632	15.71	Yes	Yes	1	4	6
33	R:R:F220	R:R:Y128	61.5235	21.66	Yes	Yes	1	6	6
34	R:R:F220	R:R:L132	58.5131	3.65	Yes	No	0	6	6
35	R:R:I167	R:R:L132	52.2331	5.71	No	No	0	7	6
36	R:R:I167	R:R:T133	50.8269	3.04	No	No	0	7	8
37	R:R:M85	R:R:T133	59.0275	9.03	No	No	0	9	8
38	R:R:L82	R:R:M85	57.7395	4.24	No	No	0	8	9
39	R:R:L82	R:R:N324	23.6072	6.87	No	No	0	8	7
40	R:R:N324	R:R:Y330	20.9245	6.98	No	Yes	3	7	8
41	R:R:L82	R:R:T78	35.466	2.95	No	No	0	8	8
42	R:R:V67	R:R:Y330	15.0903	5.05	No	Yes	0	8	8
43	R:R:F71	R:R:V67	13.749	2.62	Yes	No	0	5	8
44	R:R:L137	R:R:T78	28.26	2.95	No	No	0	8	8
45	R:R:L137	R:R:Y81	26.7967	8.21	No	Yes	0	8	8
46	R:R:I178	R:R:Q120	12.179	4.12	No	Yes	1	4	4
47	R:R:F121	R:R:I178	11.5997	3.77	Yes	No	1	6	4
48	R:R:F121	R:R:F172	12.3885	4.29	Yes	No	1	6	4
49	R:R:F172	R:R:W168	14.7092	7.02	No	No	0	4	9
50	R:R:S84	R:R:W168	11.474	6.18	No	No	0	9	9
51	R:R:T127	R:R:Y128	19.907	3.75	No	Yes	0	7	6
52	R:R:I92	R:R:T127	19.2821	3.04	No	No	0	7	7
53	R:R:F312	R:R:I92	20.6577	5.02	Yes	No	0	7	7
54	R:R:F312	R:R:Y313	37.4933	11.35	Yes	Yes	1	7	7
55	R:R:F272	R:R:W276	89.8864	15.03	Yes	Yes	1	9	8
56	R:R:F119	R:R:L98	14.2291	15.83	Yes	No	0	4	5
57	R:R:D99	R:R:R102	27.4522	8.34	Yes	Yes	1	6	5
58	R:R:D113	R:R:V184	10.3498	8.76	No	Yes	0	4	5
59	R:R:F121	R:R:F179	11.8627	16.08	Yes	No	0	6	5
60	R:R:R283	R:R:S217	15.2046	3.95	Yes	No	0	6	6
61	R:R:F272	R:R:P224	11.1615	2.89	Yes	No	0	9	9
62	R:R:F272	R:R:L228	71.0159	4.87	Yes	No	1	9	8
63	R:R:L228	R:R:S138	71.3437	6.01	No	No	0	8	9
64	R:R:L231	R:R:S138	55.9104	4.5	Yes	No	0	7	9
65	R:R:S138	R:R:Y232	15.1818	7.63	No	Yes	0	9	9
66	R:R:L231	R:R:Y142	47.5574	12.89	Yes	Yes	0	7	8
67	R:R:I235	R:R:Y142	17.6397	3.63	Yes	Yes	2	8	8
68	R:R:F147	R:R:Y142	15.3685	3.09	Yes	Yes	2	6	8
69	R:R:F147	R:R:R150	11.2568	10.69	Yes	No	0	6	5
70	L:L:?1	R:R:L181	12.823	3.96	Yes	Yes	1	0	4
71	L:L:?1	R:R:F286	12.6858	19.18	Yes	No	0	0	4
72	R:R:H186	R:R:N196	14.3549	3.83	No	Yes	0	2	4
73	R:R:V269	R:R:Y232	11.1615	5.05	No	Yes	0	8	9
74	R:R:I318	R:R:L314	19.4802	2.85	Yes	No	0	7	5
75	R:R:I318	R:R:L322	12.8725	2.85	Yes	No	7	7	8
76	R:R:L322	R:R:V268	10.6814	2.98	No	No	0	8	8
77	L:L:?1	R:R:N305	30.7027	8.85	Yes	No	0	0	4
78	R:R:G282	R:R:N305	15.5019	3.39	Yes	No	0	4	4
79	R:R:G282	R:R:L285	11.2987	3.42	Yes	Yes	4	4	4
80	R:R:N305	R:R:S301	14.0805	4.47	No	No	0	4	4
81	R:R:L285	R:R:S301	11.4511	3	Yes	No	0	4	4
82	R:R:I297	R:R:L285	17.19	1.43	No	Yes	4	1	4
83	R:R:I297	R:R:S294	14.3625	4.64	No	No	0	1	6
84	R:R:E291	R:R:S294	11.5045	4.31	No	No	0	1	6
85	R:R:A298	R:R:Q302	10.7766	1.52	No	No	0	3	3
86	R:R:F38	R:R:P39	10.7766	1.44	Yes	No	0	4	4
87	R:R:F312	R:R:W276	43.358	3.01	Yes	Yes	1	7	8
88	R:R:D99	R:R:Y313	40.3856	5.75	Yes	Yes	1	6	7
89	R:R:S84	R:R:T133	10.4908	3.2	No	No	0	9	8
90	R:R:D99	R:R:F119	15.8182	10.75	Yes	Yes	1	6	4
91	R:R:E124	R:R:R283	18.276	10.47	Yes	Yes	1	4	6
92	R:R:S217	R:R:Y128	14.1834	3.82	No	Yes	0	6	6
93	R:R:L98	R:R:W109	13.3031	7.97	No	Yes	0	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R102	13.04	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L103	5.94	1	Yes	No	0	4	0	1
L:L:?1	R:R:Q120	11.43	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S123	7.52	1	Yes	No	0	6	0	1
L:L:?1	R:R:E124	5.69	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L181	3.96	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L210	2.97	1	Yes	No	0	3	0	1
L:L:?1	R:R:V214	3.2	1	Yes	No	0	5	0	1
L:L:?1	R:R:R283	12.17	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F286	19.18	1	Yes	No	0	4	0	1
L:L:?1	R:R:N305	8.85	1	Yes	No	0	4	0	1
L:L:?1	R:R:F309	6.1	1	Yes	Yes	0	5	0	1
R:R:D99	R:R:R102	8.34	1	Yes	Yes	6	5	2	1
R:R:D99	R:R:F119	10.75	1	Yes	Yes	6	4	2	2
R:R:D99	R:R:F309	4.78	1	Yes	Yes	6	5	2	1
R:R:D99	R:R:Y313	5.75	1	Yes	Yes	6	7	2	2
R:R:F309	R:R:L100	3.65	1	Yes	Yes	5	7	1	2
R:R:F119	R:R:R102	6.41	1	Yes	Yes	4	5	2	1
R:R:Q120	R:R:R102	8.18	1	Yes	Yes	4	5	1	1
R:R:C198	R:R:R102	4.18	1	Yes	Yes	9	5	2	1
R:R:F309	R:R:L103	4.87	1	Yes	No	5	4	1	1
R:R:F119	R:R:Q120	4.68	1	Yes	Yes	4	4	2	1
R:R:I178	R:R:Q120	4.12	1	No	Yes	4	4	2	1
R:R:Q120	R:R:V182	8.6	1	Yes	No	4	4	1	2
R:R:C198	R:R:Q120	3.05	1	Yes	Yes	9	4	2	1
R:R:E124	R:R:Y128	15.71	1	Yes	Yes	4	6	1	2
R:R:A175	R:R:E124	3.02	0	No	Yes	7	4	2	1
R:R:E124	R:R:R283	10.47	1	Yes	Yes	4	6	1	1
R:R:S217	R:R:Y128	3.82	0	No	Yes	6	6	2	2
R:R:I178	R:R:V182	4.61	1	No	No	4	4	2	2
R:R:A204	R:R:L181	3.15	1	No	Yes	4	4	2	1
R:R:L181	R:R:L209	5.54	1	Yes	Yes	4	4	1	2
R:R:L181	R:R:L210	4.15	1	Yes	No	4	3	1	1
R:R:F286	R:R:P200	4.33	0	No	No	4	4	1	2
R:R:A204	R:R:L209	3.15	1	No	Yes	4	4	2	2
R:R:L210	R:R:S287	6.01	1	No	No	3	4	1	2
R:R:S287	R:R:V214	3.23	0	No	No	4	5	2	1
R:R:R283	R:R:S217	3.95	1	Yes	No	6	6	1	2
R:R:F279	R:R:R283	16.03	1	Yes	Yes	6	6	2	1
R:R:G282	R:R:N305	3.39	4	Yes	No	4	4	2	1
R:R:F286	R:R:F290	8.57	0	No	No	4	1	1	2
R:R:N305	R:R:S301	4.47	0	No	No	4	4	1	2
R:R:F309	R:R:Y313	16.5	1	Yes	Yes	5	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JSR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.96
Number of Linked Nodes	269
Number of Links	308
Number of Hubs	43
Number of Links mediated by Hubs	160
Number of Communities	7
Number of Nodes involved in Communities	59
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	68914
Length Of Smallest Path	3
Average Path Length	14.5278
Length of Longest Path	30
Minimum Path Strength	1.075
Average Path Strength	6.60323
Maximum Path Strength	18.685
Minimum Path Correlation	0.7
Average Path Correlation	0.925721
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	44.0168
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.4884
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • regulation of biological process • digestive system process • regulation of system process • regulation of gastric motility • biological regulation • regulation of digestive system process • digestion • gastric motility • regulation of multicellular organismal process • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to insulin-like growth factor stimulus • cellular response to hormone stimulus • developmental process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • regulation of tumor necrosis factor production • regulation of cellular process • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • interleukin-6 production • regulation of interleukin-6 production • negative regulation of interleukin-6 production • negative regulation of behavior • negative regulation of locomotion • locomotion involved in locomotory behavior • behavior • regulation of behavior • negative regulation of locomotion involved in locomotory behavior • locomotory behavior • regulation of locomotion • regulation of locomotion involved in locomotory behavior • locomotion • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • signaling • transport • hormone secretion • cell communication • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • growth hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of growth hormone secretion • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • intestinal motility • positive regulation of small intestinal transit • positive regulation of biological process • positive regulation of digestive system process • positive regulation of multicellular organismal process • small intestinal transit • regulation of small intestinal transit • cell surface receptor signaling pathway • insulin-like growth factor receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • signal transduction • enzyme-linked receptor protein signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of insulin-like growth factor receptor signaling pathway • regulation of insulin-like growth factor receptor signaling pathway • positive regulation of cellular process • regulation of response to stimulus • positive regulation of signaling • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • response to ketone • response to lipid • response to glucocorticoid • response to corticosteroid • response to steroid hormone • response to dexamethasone • cell population proliferation • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of epithelial cell proliferation • regulation of vascular endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of cell population proliferation • positive regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • vascular endothelial cell proliferation • epithelial cell proliferation • positive regulation of vascular endothelial cell proliferation • response to growth hormone • response to thyroid hormone • cellular response to thyroid hormone stimulus • response to acid chemical • response to L-glutamate • response to amino acid • regulation of cellular component organization • cellular component organization • cellular component biogenesis • multicellular organism development • cellular component assembly • cell junction assembly • anatomical structure development • regulation of synapse structure or activity • regulation of synapse assembly • synapse organization • cellular component organization or biogenesis • system development • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • response to gonadotropin • response to follicle-stimulating hormone • postsynapse organization • regulation of postsynapse organization • regulation of hindgut contraction • muscle contraction • muscle system process • regulation of muscle system process • hindgut contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • adult feeding behavior • adult behavior • feeding behavior • actin polymerization or depolymerization • organelle organization • actin cytoskeleton organization • actin filament organization • actin filament-based process • supramolecular fiber organization • cytoskeleton organization • positive regulation of smooth muscle contraction • intestine smooth muscle contraction • regulation of gastro-intestinal system smooth muscle contraction • positive regulation of small intestine smooth muscle contraction • regulation of small intestine smooth muscle contraction • small intestine smooth muscle contraction • gastro-intestinal system smooth muscle contraction • phasic smooth muscle contraction • positive regulation of gastro-intestinal system smooth muscle contraction • positive regulation of muscle contraction • leukocyte apoptotic process • regulation of programmed cell death • macrophage apoptotic process • negative regulation of leukocyte apoptotic process • myeloid cell apoptotic process • regulation of leukocyte apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of macrophage apoptotic process • cell death • negative regulation of apoptotic process • regulation of macrophage apoptotic process • inflammatory cell apoptotic process • negative regulation of myeloid cell apoptotic process • apoptotic process • regulation of myeloid cell apoptotic process • programmed cell death • response to nutrient levels • regulation of response to nutrient levels • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of response to stimulus • negative regulation of appetite • regulation of response to food • response to food • regulation of appetite • oxoacid metabolic process • ketone metabolic process • regulation of lipid metabolic process • organic acid metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • positive regulation of fatty acid metabolic process • fatty acid metabolic process • carboxylic acid metabolic process • primary metabolic process • regulation of ketone metabolic process • regulation of fatty acid metabolic process • monocarboxylic acid metabolic process • positive regulation of small molecule metabolic process • lipid metabolic process • hormone-mediated signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of interleukin-1 production • interleukin-1 beta production • biological process involved in interspecies interaction between organisms • response to other organism • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to external biotic stimulus • response to molecule of bacterial origin • positive regulation of appetite • positive regulation of response to food • positive regulation of response to nutrient levels • protein localization • negative regulation of protein transport • establishment of protein localization • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • cellular localization • regulation of protein localization • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • macromolecule localization • insulin secretion • ghrelin secretion • protein localization to synapse • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane • regulation of protein localization to synapse • neurotransmitter receptor localization to postsynaptic specialization membrane • regulation of protein localization to membrane • regulation of receptor localization to synapse • protein localization to postsynaptic specialization membrane • protein localization to cell periphery • protein localization to postsynaptic membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • protein-containing complex localization • regulation of postsynaptic membrane neurotransmitter receptor levels • protein localization to organelle • protein localization to postsynapse • protein localization to cell junction • receptor localization to synapse • multi-multicellular organism process • placenta development • maternal process involved in female pregnancy • animal organ development • tissue development • maternal placenta development • female pregnancy • multi-organism reproductive process • decidualization • learning or memory • nervous system process • cognition • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of developmental growth • regulation of sprouting angiogenesis • angiogenesis • regulation of vasculature development • tube morphogenesis • positive regulation of sprouting angiogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • sprouting angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • regulation of eating behavior • positive regulation of feeding behavior • eating behavior • positive regulation of eating behavior • positive regulation of behavior • regulation of feeding behavior • response to insulin • cellular response to insulin stimulus • G protein-coupled receptor signaling pathway • monoamine transport • negative regulation of amine transport • regulation of catecholamine secretion • organic hydroxy compound transport • catecholamine transport • negative regulation of norepinephrine secretion • norepinephrine transport • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • transmission of nerve impulse • regulation of nervous system process • regulation of transmission of nerve impulse • response to estradiol • cellular anatomical structure • synapse • cell junction • glutamatergic synapse • cell projection • neuron projection • plasma membrane bounded cell projection • postsynapse • cell periphery • membrane • plasma membrane • plasma membrane region • synaptic membrane • cell surface
Gene Ontology	Cellular Component	• cellular anatomical structure • synapse • cell junction • glutamatergic synapse • cell projection • neuron projection • plasma membrane bounded cell projection • postsynapse • cell periphery • membrane • plasma membrane • plasma membrane region • synaptic membrane • cell surface • membrane microdomain • membrane raft • Schaffer collateral - CA1 synapse • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UYI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UYI
Name	Anamorelin
Synonyms	Anamorelin Anamorelin Hydrochloride
Identifier
Formula	C31 H42 N6 O3
Molecular Weight	546.704
SMILES
PubChem	9828911
Formal Charge	0
Total Atoms	82
Total Chiral Atoms	2
Total Bonds	85
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92847
Sequence	>8JSR_nogp_Chain_R L F P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F R E L R T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y R P W N F G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F P L R A K V V V T K G R V K L V I F V I W A V A F C S A G P I F V L V G V E H E W D T N E C R P T E F A V R S G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E P G S L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K Y R V A V F R L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JSR	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	8JSR (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	7F83	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PF-05190457	-	-	2.94	2022-01-19	10.1038/s41467-022-27975-9
	7W2Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-	Go/β1/γ2	2.8	2022-01-19	10.1038/s41467-022-27975-9
	7W2Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-		2.8	2022-01-19	10.1038/s41467-022-27975-9
	7NA8	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-	Gi1/β1/γ2	2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA8 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-		2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA7	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-	Gi1/β1/γ2	2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA7 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-		2.7	2021-12-15	10.1038/s41467-021-26735-5
	7F9Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-08-18	10.1038/s41467-021-25364-2
	7F9Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-		3.2	2021-08-18	10.1038/s41467-021-25364-2
	7F9Y	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-08-18	10.1038/s41467-021-25364-2
	7F9Y (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-		2.9	2021-08-18	10.1038/s41467-021-25364-2
	6KO5	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 57400002	-	-	3.3	2020-08-12	10.1038/s41467-020-17554-1

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JSR_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.