psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	16.09	Yes	Yes	1	0	0
2	L:L:?1	R:R:Y106	10.1	Yes	No	0	0	3
3	L:L:?1	R:R:R199	5.23	Yes	No	0	0	3
4	L:L:?1	R:R:Q302	3.44	Yes	Yes	1	0	3
5	L:L:?2	L:L:?3	30.17	Yes	Yes	1	0	0
6	L:L:?2	L:L:?6	9.58	Yes	Yes	1	0	0
7	L:L:?2	R:R:D99	5.39	Yes	No	1	0	6
8	L:L:?2	R:R:L103	8.79	Yes	No	0	0	4
9	L:L:?2	R:R:Q302	11.62	Yes	Yes	1	0	3
10	L:L:?2	R:R:N305	3.27	Yes	Yes	1	0	4
11	L:L:?2	R:R:F309	9.67	Yes	Yes	1	0	5
12	L:L:?3	L:L:?4	17.88	Yes	Yes	1	0	0
13	L:L:?3	R:R:F286	9.91	Yes	Yes	1	0	4
14	L:L:?3	R:R:N305	22.35	Yes	Yes	1	0	4
15	L:L:?4	L:L:?5	13.96	Yes	Yes	1	0	0
16	L:L:?4	L:L:?6	9.58	Yes	Yes	1	0	0
17	L:L:?4	R:R:F286	3.87	Yes	Yes	1	0	4
18	L:L:?4	R:R:S308	4.77	Yes	No	0	0	7
19	L:L:?4	R:R:F309	8.7	Yes	Yes	1	0	5
20	L:L:?5	L:L:?6	28.64	Yes	Yes	1	0	0
21	L:L:?5	L:L:?7	5.81	Yes	Yes	1	0	0
22	L:L:?5	R:R:E124	5.61	Yes	Yes	1	0	4
23	L:L:?5	R:R:L181	11.73	Yes	No	1	0	4
24	L:L:?5	R:R:P200	6.96	Yes	No	0	0	4
25	L:L:?5	R:R:M213	11.98	Yes	No	1	0	5
26	L:L:?5	R:R:R283	27.79	Yes	Yes	1	0	6
27	L:L:?6	L:L:?7	23.9	Yes	Yes	1	0	0
28	L:L:?6	R:R:D99	4.73	Yes	No	1	0	6
29	L:L:?6	R:R:Q120	22.05	Yes	Yes	1	0	4
30	L:L:?6	R:R:E124	6.93	Yes	Yes	1	0	4
31	L:L:?6	R:R:I178	4.98	Yes	No	1	0	4
32	L:L:?7	R:R:Q120	9.88	Yes	Yes	1	0	4
33	L:L:?7	R:R:E124	13.12	Yes	Yes	1	0	4
34	R:R:L42	R:R:P39	4.93	No	No	0	3	4
35	R:R:L43	R:R:W104	3.42	No	No	0	5	4
36	R:R:T47	R:R:W104	4.85	No	No	0	6	4
37	R:R:C50	R:R:L100	3.17	No	No	0	6	7
38	R:R:L314	R:R:L53	4.15	No	No	0	5	7
39	R:R:F54	R:R:I58	12.56	No	No	0	7	6
40	R:R:F54	R:R:F93	5.36	No	Yes	0	7	6
41	R:R:F54	R:R:M96	6.22	No	Yes	0	7	7
42	R:R:G60	R:R:P320	4.06	No	No	0	8	9
43	R:R:A86	R:R:N61	4.69	No	Yes	0	9	9
44	R:R:D89	R:R:N61	8.08	No	Yes	0	9	9
45	R:R:F93	R:R:N61	3.62	Yes	Yes	0	6	9
46	R:R:N61	R:R:P320	6.52	Yes	No	0	9	9
47	R:R:L63	R:R:Y330	3.52	No	Yes	0	6	8
48	R:R:A86	R:R:T64	3.36	No	No	0	9	9
49	R:R:P320	R:R:T64	3.5	No	No	0	9	9
50	R:R:F87	R:R:M65	3.73	No	No	0	6	7
51	R:R:V67	R:R:Y330	5.05	No	Yes	0	8	8
52	R:R:L74	R:R:V68	4.47	Yes	No	2	8	7
53	R:R:N79	R:R:V68	7.39	No	No	2	8	7
54	R:R:F71	R:R:R70	4.28	No	No	0	5	5
55	R:R:E73	R:R:F71	3.5	No	No	0	6	5
56	R:R:F71	R:R:L74	3.65	No	Yes	0	5	8
57	R:R:R72	R:R:R75	10.66	No	No	0	6	7
58	R:R:L74	R:R:N79	9.61	Yes	No	2	8	8
59	R:R:T76	R:R:T77	4.71	No	Yes	2	7	7
60	R:R:T76	R:R:T78	3.14	No	No	2	7	8
61	R:R:N79	R:R:T76	4.39	No	No	2	8	7
62	R:R:T77	R:R:T78	3.14	Yes	No	2	7	8
63	R:R:E140	R:R:T77	12.7	No	Yes	0	9	7
64	R:R:T77	R:R:V160	3.17	Yes	No	0	7	7
65	R:R:A136	R:R:Y81	4	No	Yes	0	7	8
66	R:R:L137	R:R:Y81	9.38	No	Yes	0	8	8
67	R:R:E140	R:R:Y81	11.22	No	Yes	0	9	8
68	R:R:V160	R:R:Y81	3.79	No	Yes	0	7	8
69	R:R:L82	R:R:M85	4.24	No	Yes	0	8	9
70	R:R:L82	R:R:Y323	5.86	No	No	0	8	9
71	R:R:I164	R:R:S84	4.64	No	No	0	7	9
72	R:R:S84	R:R:W168	3.71	No	Yes	0	9	9
73	R:R:M85	R:R:T133	6.02	Yes	No	0	9	8
74	R:R:I134	R:R:M85	4.37	No	Yes	0	8	9
75	R:R:C126	R:R:S88	5.16	No	No	0	8	8
76	R:R:S88	R:R:T130	4.8	No	No	0	8	9
77	R:R:A316	R:R:D89	3.09	No	No	0	9	9
78	R:R:D89	R:R:N319	4.04	No	No	0	9	9
79	R:R:L91	R:R:V122	4.47	No	No	0	7	5
80	R:R:C126	R:R:L91	4.76	No	No	0	8	7
81	R:R:F93	R:R:I92	3.77	Yes	Yes	1	6	7
82	R:R:C126	R:R:I92	4.91	No	Yes	0	8	7
83	R:R:F312	R:R:I92	3.77	Yes	Yes	1	7	7
84	R:R:I92	R:R:Y313	3.63	Yes	Yes	1	7	7
85	R:R:F93	R:R:Y313	4.13	Yes	Yes	1	6	7
86	R:R:C95	R:R:F119	4.19	No	Yes	0	6	4
87	R:R:C95	R:R:S123	3.44	No	No	0	6	6
88	R:R:L100	R:R:M96	4.24	No	Yes	0	7	7
89	R:R:M96	R:R:Y313	8.38	Yes	Yes	0	7	7
90	R:R:F111	R:R:L98	7.31	No	No	0	6	5
91	R:R:F119	R:R:L98	6.09	Yes	No	0	4	5
92	R:R:D99	R:R:F309	9.55	No	Yes	1	6	5
93	R:R:R102	R:R:V101	5.23	No	No	0	5	4
94	R:R:P108	R:R:V101	3.53	No	No	0	4	4
95	R:R:R102	R:R:W109	11	No	Yes	0	5	7
96	R:R:Q105	R:R:W104	8.76	No	No	0	4	4
97	R:R:P108	R:R:Q105	4.74	No	No	0	4	4
98	R:R:E197	R:R:Y106	8.98	No	No	0	4	3
99	R:R:C116	R:R:W109	5.22	No	Yes	4	9	7
100	R:R:V184	R:R:W109	4.9	No	Yes	0	5	7
101	R:R:C198	R:R:W109	5.22	No	Yes	4	9	7
102	R:R:F111	R:R:L115	4.87	No	No	0	6	5
103	R:R:D113	R:R:K117	16.59	No	No	0	4	7
104	R:R:D113	R:R:G183	5.03	No	No	0	4	4
105	R:R:D113	R:R:V184	8.76	No	No	0	4	5
106	R:R:C116	R:R:F119	4.19	No	Yes	0	9	4
107	R:R:C116	R:R:C198	7.28	No	No	4	9	9
108	R:R:F119	R:R:Q120	4.68	Yes	Yes	0	4	4
109	R:R:F121	R:R:F172	7.5	Yes	No	0	6	4
110	R:R:F121	R:R:F179	9.65	Yes	No	0	6	5
111	R:R:E124	R:R:Y128	4.49	Yes	No	0	4	6
112	R:R:E124	R:R:I178	6.83	Yes	No	1	4	4
113	R:R:E124	R:R:R283	5.82	Yes	Yes	1	4	6
114	R:R:F172	R:R:S125	5.28	No	No	0	4	5
115	R:R:F312	R:R:T127	5.19	Yes	No	0	7	7
116	R:R:S217	R:R:Y128	5.09	No	No	0	6	6
117	R:R:F220	R:R:Y128	10.32	No	No	0	6	6
118	R:R:A129	R:R:W168	9.08	No	Yes	0	6	9
119	R:R:T130	R:R:T133	3.14	No	No	0	9	8
120	R:R:P224	R:R:V131	3.53	No	No	0	9	8
121	R:R:V131	R:R:W276	4.9	No	Yes	0	8	8
122	R:R:I167	R:R:L132	4.28	No	No	0	7	6
123	R:R:F272	R:R:I134	6.28	Yes	No	0	9	8
124	R:R:P224	R:R:T135	3.5	No	No	0	9	7
125	R:R:L228	R:R:S138	6.01	Yes	No	3	8	9
126	R:R:L231	R:R:S138	6.01	Yes	No	0	7	9
127	R:R:S138	R:R:Y232	5.09	No	Yes	3	9	9
128	R:R:R141	R:R:Y232	9.26	No	Yes	0	9	9
129	R:R:R141	R:R:Y323	4.12	No	No	0	9	9
130	R:R:F143	R:R:Y142	4.13	No	Yes	0	5	8
131	R:R:C146	R:R:Y142	9.41	No	Yes	0	7	8
132	R:R:L231	R:R:Y142	14.07	Yes	Yes	0	7	8
133	R:R:L234	R:R:Y142	7.03	No	Yes	0	5	8
134	R:R:I145	R:R:I235	11.77	No	No	0	9	8
135	R:R:I145	R:R:K238	4.36	No	No	0	9	5
136	R:R:C146	R:R:F147	13.97	No	No	0	7	6
137	R:R:C146	R:R:K238	3.23	No	No	0	7	5
138	R:R:F147	R:R:R150	5.34	No	No	0	6	5
139	R:R:L149	R:R:P148	3.28	No	No	0	7	8
140	R:R:R159	R:R:V154	13.08	No	No	0	5	4
141	R:R:F172	R:R:W168	8.02	No	Yes	0	4	9
142	R:R:F220	R:R:S174	7.93	No	No	0	6	5
143	R:R:G176	R:R:P177	4.06	No	No	0	4	7
144	R:R:L181	R:R:M213	7.07	No	No	1	4	5
145	R:R:N196	R:R:V184	5.91	No	No	0	4	5
146	R:R:E185	R:R:R199	20.93	No	No	0	1	3
147	R:R:H186	R:R:T195	5.48	No	No	0	2	3
148	R:R:H186	R:R:N196	7.65	No	No	0	2	4
149	R:R:E187	R:R:T190	8.47	No	No	5	3	3
150	R:R:E187	R:R:T195	4.23	No	No	5	3	3
151	R:R:T190	R:R:T195	7.85	No	No	5	3	3
152	R:R:D191	R:R:P192	6.44	No	No	0	6	1
153	R:R:D191	R:R:W193	5.58	No	No	0	6	4
154	R:R:D191	R:R:D194	5.32	No	No	0	6	5
155	R:R:E197	R:R:R199	5.82	No	No	0	4	3
156	R:R:E202	R:R:V205	12.84	No	No	0	6	4
157	R:R:F203	R:R:S207	5.28	No	No	0	6	3
158	R:R:A204	R:R:L209	4.73	No	No	0	4	4
159	R:R:F290	R:R:V205	14.42	No	No	0	1	4
160	R:R:G208	R:R:S207	3.71	No	No	0	2	3
161	R:R:L209	R:R:V212	5.96	No	No	0	4	6
162	R:R:V212	R:R:V216	6.41	No	No	0	6	5
163	R:R:V214	R:R:W215	9.81	No	No	0	5	4
164	R:R:V214	R:R:Y284	3.79	No	No	0	5	5
165	R:R:S287	R:R:V214	3.23	No	No	0	4	5
166	R:R:H280	R:R:S217	6.97	Yes	No	0	7	6
167	R:R:R283	R:R:S217	7.91	Yes	No	0	6	6
168	R:R:F222	R:R:S218	3.96	No	No	0	4	4
169	R:R:F221	R:R:V225	5.24	No	No	0	8	6
170	R:R:F221	R:R:L277	6.09	No	No	0	8	6
171	R:R:F221	R:R:H280	18.1	No	Yes	0	8	7
172	R:R:L223	R:R:P224	3.28	No	No	0	5	9
173	R:R:C227	R:R:L223	3.17	No	No	0	6	5
174	R:R:F272	R:R:V225	5.24	Yes	No	0	9	6
175	R:R:F226	R:R:V230	3.93	No	No	0	3	4
176	R:R:L228	R:R:Y232	10.55	Yes	Yes	3	8	9
177	R:R:L228	R:R:V269	5.96	Yes	No	3	8	8
178	R:R:F272	R:R:L228	6.09	Yes	Yes	0	9	8
179	R:R:L265	R:R:Y232	7.03	No	Yes	0	8	9
180	R:R:V269	R:R:Y232	5.05	No	Yes	3	8	9
181	R:R:L234	R:R:R237	3.64	No	No	0	5	4
182	R:R:G236	R:R:I235	3.53	No	No	0	5	8
183	R:R:H258	R:R:L239	11.57	No	No	0	6	8
184	R:R:K259	R:R:W240	12.76	No	No	0	5	4
185	R:R:K259	R:R:N257	4.2	No	No	0	5	5
186	R:R:K259	R:R:K263	10.06	No	No	0	5	7
187	R:R:L265	R:R:T261	4.42	No	No	0	8	8
188	R:R:M264	R:R:M326	4.33	No	No	0	8	7
189	R:R:L322	R:R:V268	4.47	No	No	0	8	8
190	R:R:V268	R:R:Y323	5.05	No	No	0	8	9
191	R:R:F272	R:R:W276	14.03	Yes	Yes	0	9	8
192	R:R:C275	R:R:L311	4.76	No	Yes	0	9	7
193	R:R:C275	R:R:S315	6.89	No	No	0	9	9
194	R:R:F279	R:R:W276	12.03	No	Yes	0	6	8
195	R:R:F312	R:R:W276	6.01	Yes	Yes	0	7	8
196	R:R:L277	R:R:P278	3.28	No	No	0	6	9
197	R:R:P278	R:R:S308	3.56	No	No	0	9	7
198	R:R:F279	R:R:H280	7.92	No	Yes	0	6	7
199	R:R:F279	R:R:R283	8.55	No	Yes	0	6	6
200	R:R:C304	R:R:G282	3.92	No	No	0	5	4
201	R:R:G282	R:R:N305	3.39	No	Yes	0	4	4
202	R:R:L285	R:R:S301	4.5	No	No	0	4	4
203	R:R:F286	R:R:S289	3.96	Yes	No	0	4	2
204	R:R:F286	R:R:F290	8.57	Yes	No	0	4	1
205	R:R:E291	R:R:K288	6.75	No	No	0	1	4
206	R:R:E296	R:R:S294	7.19	No	No	0	2	6
207	R:R:L295	R:R:Q299	6.65	No	No	0	7	1
208	R:R:N305	R:R:S301	4.47	Yes	No	0	4	4
209	R:R:F309	R:R:Y313	14.44	Yes	Yes	1	5	7
210	R:R:F312	R:R:Y313	4.13	Yes	Yes	1	7	7
211	R:R:I318	R:R:L314	7.14	No	No	0	7	5
212	R:R:I318	R:R:L322	4.28	No	No	0	7	8
213	R:R:N324	R:R:Y330	23.26	No	Yes	0	7	8
214	R:R:K328	R:R:R331	6.19	No	No	0	5	8
215	R:R:I167	R:R:V163	3.07	No	No	0	7	6
216	R:R:I273	R:R:V225	3.07	No	No	0	6	6
217	R:R:H186	R:R:P192	3.05	No	No	0	2	1
218	R:R:F93	R:R:G57	3.01	Yes	No	0	6	8
219	R:R:F87	R:R:W168	3.01	No	Yes	0	6	9
220	R:R:F121	R:R:G176	3.01	Yes	No	0	6	4
221	R:R:L63	R:R:V334	2.98	No	No	0	6	6
222	R:R:L231	R:R:V139	2.98	Yes	No	0	7	7
223	R:R:L231	R:R:V230	2.98	Yes	No	0	7	4
224	R:R:L239	R:R:V262	2.98	No	No	0	8	7
225	R:R:L311	R:R:V307	2.98	Yes	No	0	7	5
226	R:R:L53	R:R:T49	2.95	No	No	0	7	5
227	R:R:L210	R:R:T211	2.95	No	No	0	3	4
228	R:R:N324	R:R:T64	2.92	No	No	0	7	9
229	R:R:Q120	R:R:V182	2.87	Yes	No	0	4	4
230	R:R:I58	R:R:L62	2.85	No	No	0	6	3
231	R:R:I235	R:R:L239	2.85	No	No	0	8	8
232	R:R:I300	R:R:L285	2.85	No	No	0	2	4
233	R:R:L90	R:R:M65	2.83	No	No	0	7	7
234	R:R:L137	R:R:M85	2.83	No	Yes	0	8	9
235	R:R:K329	R:R:L74	2.82	No	Yes	0	6	8
236	R:R:H280	R:R:S218	2.79	Yes	No	0	7	4
237	R:R:L306	R:R:L42	2.77	No	No	0	4	3
238	R:R:A175	R:R:F121	2.77	No	Yes	0	7	6
239	R:R:L274	R:R:L311	2.77	No	Yes	0	5	7
240	R:R:L306	R:R:Q302	2.66	No	Yes	0	4	3
241	R:R:R75	R:R:V68	2.62	No	No	0	7	7
242	R:R:S327	R:R:Y330	2.54	No	Yes	0	8	8
243	R:R:V163	R:R:Y81	2.52	No	Yes	0	6	8
244	R:R:F121	R:R:I178	2.51	Yes	No	0	6	4
245	R:R:S218	R:R:W215	2.47	No	No	0	4	4
246	R:R:F270	R:R:L274	2.44	No	No	0	5	5
247	R:R:T211	R:R:W215	2.43	No	No	0	4	4
248	R:R:K288	R:R:Y284	2.39	No	No	0	4	5
249	R:R:E202	R:R:R206	2.33	No	No	0	6	1
250	R:R:Q299	R:R:Y303	2.25	No	No	0	1	1
251	R:R:A44	R:R:G45	1.95	No	No	0	4	6
252	R:R:A317	R:R:G57	1.95	No	No	0	7	8
253	R:R:A59	R:R:G60	1.95	No	No	0	3	8
254	R:R:A40	R:R:P41	1.87	No	No	0	2	2
255	R:R:G57	R:R:V56	1.84	No	No	0	8	6
256	R:R:G282	R:R:V281	1.84	No	No	0	4	7
257	R:R:G183	R:R:T201	1.82	No	No	0	4	3
258	R:R:A129	R:R:A171	1.79	No	No	0	6	8
259	R:R:A144	R:R:A151	1.79	No	No	0	8	6
260	R:R:G158	R:R:K161	1.74	No	No	0	4	3
261	R:R:C50	R:R:V46	1.71	No	No	0	6	4
262	R:R:M96	R:R:P97	1.68	Yes	No	0	7	7
263	R:R:A204	R:R:T201	1.68	No	No	0	4	3
264	R:R:L311	R:R:P278	1.64	Yes	No	0	7	9
265	R:R:S174	R:R:V170	1.62	No	No	0	5	4
266	R:R:V310	R:R:V46	1.6	No	No	0	5	4
267	R:R:V153	R:R:V154	1.6	No	No	0	4	4
268	R:R:V163	R:R:V166	1.6	No	No	0	6	4
269	R:R:T77	R:R:V155	1.59	Yes	No	0	7	7
270	R:R:T229	R:R:V269	1.59	No	No	0	5	8
271	R:R:A333	R:R:L74	1.58	No	Yes	0	6	8
272	R:R:E291	R:R:P292	1.57	No	No	0	1	2
273	R:R:F111	R:R:G112	1.51	No	No	0	6	8
274	R:R:M326	R:R:T261	1.51	No	No	0	7	8
275	R:R:L209	R:R:S207	1.5	No	No	0	4	3
276	R:R:L295	R:R:S294	1.5	No	No	0	7	6
277	R:R:L80	R:R:V160	1.49	No	No	0	5	7
278	R:R:I321	R:R:I325	1.47	No	No	0	6	6
279	R:R:P108	R:R:R107	1.44	No	No	0	4	4
280	R:R:F147	R:R:P148	1.44	No	No	0	6	8
281	R:R:K157	R:R:K161	1.44	No	No	0	3	3
282	R:R:I219	R:R:L223	1.43	No	No	0	5	5
283	R:R:I325	R:R:L322	1.43	No	No	0	6	8
284	R:R:L66	R:R:M65	1.41	No	No	0	3	7
285	R:R:K157	R:R:L80	1.41	No	No	0	3	5
286	R:R:K117	R:R:L114	1.41	No	No	0	7	4
287	R:R:A151	R:R:F143	1.39	No	No	0	6	5
288	R:R:L91	R:R:L94	1.38	No	No	0	7	5
289	R:R:H258	R:R:N257	1.28	No	No	0	6	5
290	R:R:Q302	R:R:Y303	1.13	Yes	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.715	4	1	0
2	L:L:?2	11.8225	8	1	0
3	L:L:?3	20.0775	4	1	0
4	L:L:?4	9.79333	6	1	0
5	L:L:?5	14.06	8	1	0
6	L:L:?6	13.7987	8	1	0
7	L:L:?7	13.1775	4	1	0
8	R:R:N61	5.7275	4	0	9
9	R:R:L74	4.426	5	2	8
10	R:R:T77	5.062	5	2	7
11	R:R:Y81	6.182	5	0	8
12	R:R:M85	4.365	4	0	9
13	R:R:I92	4.02	4	1	7
14	R:R:F93	3.978	5	1	6
15	R:R:M96	5.13	4	0	7
16	R:R:W109	6.585	4	4	7
17	R:R:F119	4.7875	4	0	4
18	R:R:Q120	9.87	4	1	4
19	R:R:F121	5.088	5	0	6
20	R:R:E124	7.13333	6	1	4
21	R:R:Y142	8.66	4	0	8
22	R:R:W168	5.955	4	0	9
23	R:R:L228	7.1525	4	3	8
24	R:R:L231	6.51	4	0	7
25	R:R:Y232	7.396	5	3	9
26	R:R:F272	7.91	4	0	9
27	R:R:W276	9.2425	4	0	8
28	R:R:H280	8.945	4	0	7
29	R:R:R283	12.5175	4	1	6
30	R:R:F286	6.5775	4	1	4
31	R:R:Q302	4.7125	4	1	3
32	R:R:N305	8.37	4	1	4
33	R:R:F309	10.59	4	1	5
34	R:R:L311	3.0375	4	0	7
35	R:R:F312	4.775	4	1	7
36	R:R:Y313	6.942	5	1	7
37	R:R:Y330	8.5925	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:?6	19.6608	9.58	Yes	Yes	1	0	0
2	L:L:?4	L:L:?6	13.5581	9.58	Yes	Yes	1	0	0
3	L:L:?2	R:R:F309	20.9096	9.67	Yes	Yes	1	0	5
4	L:L:?4	R:R:F309	16.4883	8.7	Yes	Yes	1	0	5
5	L:L:?5	L:L:?6	20.4309	28.64	Yes	Yes	1	0	0
6	L:L:?5	R:R:R283	42.5115	27.79	Yes	Yes	1	0	6
7	L:L:?6	R:R:Q120	62.778	22.05	Yes	Yes	1	0	4
8	L:L:?6	R:R:I178	11.6661	4.98	Yes	No	1	0	4
9	R:R:F119	R:R:Q120	95.6162	4.68	Yes	Yes	0	4	4
10	R:R:C116	R:R:F119	79.6585	4.19	No	Yes	0	9	4
11	R:R:C116	R:R:W109	74.8854	5.22	No	Yes	4	9	7
12	R:R:R102	R:R:W109	19.7589	11	No	Yes	0	5	7
13	R:R:R102	R:R:V101	17.518	5.23	No	No	0	5	4
14	R:R:P108	R:R:V101	15.0319	3.53	No	No	0	4	4
15	R:R:P108	R:R:Q105	10.0453	4.74	No	No	0	4	4
16	R:R:F309	R:R:Y313	45.7964	14.44	Yes	Yes	1	5	7
17	R:R:M96	R:R:Y313	10.4346	8.38	Yes	Yes	0	7	7
18	R:R:F312	R:R:Y313	26.1154	4.13	Yes	Yes	1	7	7
19	R:R:F312	R:R:W276	37.62	6.01	Yes	Yes	0	7	8
20	R:R:F272	R:R:W276	100	14.03	Yes	Yes	0	9	8
21	R:R:F272	R:R:I134	61.6243	6.28	Yes	No	0	9	8
22	R:R:I134	R:R:M85	60.6062	4.37	No	Yes	0	8	9
23	R:R:L82	R:R:M85	13.6273	4.24	No	Yes	0	8	9
24	R:R:L82	R:R:Y323	12.4333	5.86	No	No	0	8	9
25	R:R:V268	R:R:Y323	19.8829	5.05	No	No	0	8	9
26	R:R:L322	R:R:V268	17.4574	4.47	No	No	0	8	8
27	R:R:I318	R:R:L322	10.0107	4.28	No	No	0	7	8
28	R:R:F272	R:R:L228	53.0297	6.09	Yes	Yes	0	9	8
29	R:R:L228	R:R:Y232	16.4826	10.55	Yes	Yes	3	8	9
30	R:R:R141	R:R:Y232	12.2401	9.26	No	Yes	0	9	9
31	R:R:R141	R:R:Y323	11.3027	4.12	No	No	0	9	9
32	R:R:F93	R:R:Y313	32.2614	4.13	Yes	Yes	1	6	7
33	R:R:F93	R:R:N61	37.0634	3.62	Yes	Yes	0	6	9
34	R:R:N61	R:R:P320	16.9527	6.52	Yes	No	0	9	9
35	R:R:A86	R:R:N61	13.5264	4.69	No	Yes	0	9	9
36	R:R:A86	R:R:T64	11.8334	3.36	No	No	0	9	9
37	R:R:N324	R:R:T64	20.2665	2.92	No	No	0	7	9
38	R:R:N324	R:R:Y330	17.2094	23.26	No	Yes	0	7	8
39	R:R:P320	R:R:T64	11.8738	3.5	No	No	0	9	9
40	R:R:F121	R:R:I178	18.8706	2.51	Yes	No	0	6	4
41	R:R:F121	R:R:F172	13.1313	7.5	Yes	No	0	6	4
42	R:R:F172	R:R:W168	10.7951	8.02	No	Yes	0	4	9
43	R:R:L137	R:R:M85	53.6469	2.83	No	Yes	0	8	9
44	R:R:L137	R:R:Y81	52.4183	9.38	No	Yes	0	8	8
45	R:R:E140	R:R:Y81	19.8339	11.22	No	Yes	0	9	8
46	R:R:E140	R:R:T77	18.6341	12.7	No	Yes	0	9	7
47	R:R:T76	R:R:T77	29.5475	4.71	No	Yes	2	7	7
48	R:R:N79	R:R:T76	26.8711	4.39	No	No	2	8	7
49	R:R:L74	R:R:N79	15.9288	9.61	Yes	No	2	8	8
50	R:R:V160	R:R:Y81	25.2473	3.79	No	Yes	0	7	8
51	R:R:T77	R:R:V160	18.7927	3.17	Yes	No	0	7	7
52	R:R:C126	R:R:I92	11.3056	4.91	No	Yes	0	8	7
53	R:R:V184	R:R:W109	54.1113	4.9	No	Yes	0	5	7
54	R:R:D113	R:R:V184	29.8647	8.76	No	No	0	4	5
55	R:R:D113	R:R:G183	22.4757	5.03	No	No	0	4	4
56	L:L:?6	R:R:E124	25.6107	6.93	Yes	Yes	1	0	4
57	R:R:E124	R:R:Y128	11.2451	4.49	Yes	No	0	4	6
58	R:R:R283	R:R:S217	13.6042	7.91	Yes	No	0	6	6
59	R:R:E124	R:R:R283	45.6667	5.82	Yes	Yes	1	4	6
60	R:R:L228	R:R:S138	33.2478	6.01	Yes	No	3	8	9
61	R:R:L231	R:R:S138	33.441	6.01	Yes	No	0	7	9
62	R:R:L231	R:R:Y142	28.5496	14.07	Yes	Yes	0	7	8
63	R:R:C146	R:R:Y142	21.0394	9.41	No	Yes	0	7	8
64	R:R:C146	R:R:K238	14.6194	3.23	No	No	0	7	5
65	R:R:I145	R:R:K238	13.3187	4.36	No	No	0	9	5
66	R:R:I145	R:R:I235	12.0151	11.77	No	No	0	9	8
67	R:R:N196	R:R:V184	22.4728	5.91	No	No	0	4	5
68	R:R:H186	R:R:N196	20.0012	7.65	No	No	0	2	4
69	R:R:H186	R:R:P192	10.0453	3.05	No	No	0	2	1
70	R:R:G183	R:R:T201	20.0012	1.82	No	No	0	4	3
71	R:R:A204	R:R:T201	17.5208	1.68	No	No	0	4	3
72	R:R:A204	R:R:L209	15.0348	4.73	No	No	0	4	4
73	R:R:H280	R:R:S217	19.9319	6.97	Yes	No	0	7	6
74	R:R:H280	R:R:S218	30.3579	2.79	Yes	No	0	7	4
75	R:R:S218	R:R:W215	24.8897	2.47	No	No	0	4	4
76	R:R:V214	R:R:W215	16.6441	9.81	No	No	0	5	4
77	R:R:F279	R:R:R283	78.1732	8.55	No	Yes	0	6	6
78	R:R:F279	R:R:H280	19.6522	7.92	No	Yes	0	6	7
79	R:R:V214	R:R:Y284	11.1182	3.79	No	No	0	5	5
80	R:R:F221	R:R:H280	10.5269	18.1	No	Yes	0	8	7
81	R:R:F272	R:R:V225	10.6365	5.24	Yes	No	0	9	6
82	L:L:?5	L:L:?7	18.115	5.81	Yes	Yes	1	0	0
83	R:R:F279	R:R:W276	75.8486	12.03	No	Yes	0	6	8
84	R:R:F221	R:R:V225	11.6344	5.24	No	No	0	8	6
85	L:L:?7	R:R:Q120	37.1788	9.88	Yes	Yes	1	0	4
86	L:L:?7	R:R:E124	20.0819	13.12	Yes	Yes	1	0	4
87	R:R:F312	R:R:I92	12.3208	3.77	Yes	Yes	1	7	7
88	R:R:F93	R:R:I92	15.5712	3.77	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y106	10.1	1	Yes	No	0	3	0	1
L:L:?1	R:R:R199	5.23	1	Yes	No	0	3	0	1
L:L:?1	R:R:Q302	3.44	1	Yes	Yes	0	3	0	1
L:L:?2	R:R:D99	5.39	1	Yes	No	0	6	0	1
L:L:?2	R:R:L103	8.79	1	Yes	No	0	4	0	1
L:L:?2	R:R:Q302	11.62	1	Yes	Yes	0	3	0	1
L:L:?2	R:R:N305	3.27	1	Yes	Yes	0	4	0	1
L:L:?2	R:R:F309	9.67	1	Yes	Yes	0	5	0	1
L:L:?3	R:R:F286	9.91	1	Yes	Yes	0	4	0	1
L:L:?3	R:R:N305	22.35	1	Yes	Yes	0	4	0	1
L:L:?4	R:R:F286	3.87	1	Yes	Yes	0	4	0	1
L:L:?4	R:R:S308	4.77	1	Yes	No	0	7	0	1
L:L:?4	R:R:F309	8.7	1	Yes	Yes	0	5	0	1
L:L:?5	R:R:E124	5.61	1	Yes	Yes	0	4	0	1
L:L:?5	R:R:L181	11.73	1	Yes	No	0	4	0	1
L:L:?5	R:R:P200	6.96	1	Yes	No	0	4	0	1
L:L:?5	R:R:M213	11.98	1	Yes	No	0	5	0	1
L:L:?5	R:R:R283	27.79	1	Yes	Yes	0	6	0	1
L:L:?6	R:R:D99	4.73	1	Yes	No	0	6	0	1
L:L:?6	R:R:Q120	22.05	1	Yes	Yes	0	4	0	1
L:L:?6	R:R:E124	6.93	1	Yes	Yes	0	4	0	1
L:L:?6	R:R:I178	4.98	1	Yes	No	0	4	0	1
L:L:?7	R:R:Q120	9.88	1	Yes	Yes	0	4	0	1
L:L:?7	R:R:E124	13.12	1	Yes	Yes	0	4	0	1
R:R:D99	R:R:F309	9.55	1	No	Yes	6	5	1	1
R:R:E197	R:R:Y106	8.98	0	No	No	4	3	2	1
R:R:F119	R:R:Q120	4.68	0	Yes	Yes	4	4	2	1
R:R:E124	R:R:Y128	4.49	1	Yes	No	4	6	1	2
R:R:E124	R:R:I178	6.83	1	Yes	No	4	4	1	1
R:R:E124	R:R:R283	5.82	1	Yes	Yes	4	6	1	1
R:R:S217	R:R:Y128	5.09	0	No	No	6	6	2	2
R:R:L181	R:R:M213	7.07	1	No	No	4	5	1	1
R:R:E185	R:R:R199	20.93	0	No	No	1	3	2	1
R:R:E197	R:R:R199	5.82	0	No	No	4	3	2	1
R:R:R283	R:R:S217	7.91	1	Yes	No	6	6	1	2
R:R:P278	R:R:S308	3.56	0	No	No	9	7	2	1
R:R:F279	R:R:R283	8.55	0	No	Yes	6	6	2	1
R:R:G282	R:R:N305	3.39	0	No	Yes	4	4	2	1
R:R:F286	R:R:S289	3.96	1	Yes	No	4	2	1	2
R:R:F286	R:R:F290	8.57	1	Yes	No	4	1	1	2
R:R:N305	R:R:S301	4.47	1	Yes	No	4	4	1	2
R:R:F309	R:R:Y313	14.44	1	Yes	Yes	5	7	1	2
R:R:Q120	R:R:V182	2.87	1	Yes	No	4	4	1	2
R:R:L306	R:R:Q302	2.66	0	No	Yes	4	3	2	1
R:R:F121	R:R:I178	2.51	0	Yes	No	6	4	2	1
R:R:Q302	R:R:Y303	1.13	1	Yes	No	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F9Z_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.09
Number of Linked Nodes	261
Number of Links	290
Number of Hubs	37
Number of Links mediated by Hubs	133
Number of Communities	5
Number of Nodes involved in Communities	38
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	78805
Length Of Smallest Path	3
Average Path Length	14.3436
Length of Longest Path	31
Minimum Path Strength	1.425
Average Path Strength	7.36297
Maximum Path Strength	28.215
Minimum Path Correlation	0.7
Average Path Correlation	0.919486
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	43.1287
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.3192
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DHI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DHI
Name	D-HISTIDINE
Synonyms
Identifier
Formula	C6 H10 N3 O2
Molecular Weight	156.162
SMILES
PubChem	5288059
Formal Charge	1
Total Atoms	21
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	5


Code	DTR
PDB Residues	L:L:?2 L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid DTR D-Tryptophan (R)-tryptophan
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	DAL
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Ala
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	6919011
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	DLY
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	DLY
Name	D-Lysine
Synonyms	D-Lysine (R)-2,6-diaminohexanoic acid D-Lysin D-2,6-Diaminohexanoic acid
Identifier
Formula	C6 H14 N2 O2
Molecular Weight	146.188
SMILES
PubChem	57449
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92847
Sequence	>7F9Z_nogp_Chain_R P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F R E L R T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y R P W N F G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F P L R A K V V V T K G R V K L V I F V I W A V A F C S A G P I F V L V G V E H E N G T D P W D T N E C R P T E F A V R S G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E P G S L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K Y R V A V F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JSR	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	8JSR (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	7F83	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PF-05190457	-	-	2.94	2022-01-19	10.1038/s41467-022-27975-9
	7W2Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-	Go/β1/γ2	2.8	2022-01-19	10.1038/s41467-022-27975-9
	7W2Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-		2.8	2022-01-19	10.1038/s41467-022-27975-9
	7NA8	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-	Gi1/β1/γ2	2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA8 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-		2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA7	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-	Gi1/β1/γ2	2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA7 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-		2.7	2021-12-15	10.1038/s41467-021-26735-5
	7F9Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-08-18	10.1038/s41467-021-25364-2
	7F9Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-		3.2	2021-08-18	10.1038/s41467-021-25364-2
	7F9Y	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-08-18	10.1038/s41467-021-25364-2
	7F9Y (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-		2.9	2021-08-18	10.1038/s41467-021-25364-2
	6KO5	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 57400002	-	-	3.3	2020-08-12	10.1038/s41467-020-17554-1

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