Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?3 7.46429710
2L:L:L5 8.642510
3L:L:H9 7.844510
4R:R:F38 8.576504
5R:R:L43 7.7075405
6R:R:Y81 5.806508
7R:R:D89 4.935409
8R:R:F93 4.19857716
9R:R:M96 5.17417
10R:R:R102 7.13415
11R:R:Y106 6.4025413
12R:R:W109 4.88617
13R:R:F119 7.486514
14R:R:Q120 8.8425414
15R:R:E124 6.225414
16R:R:Y128 10.2575406
17R:R:I134 4.1325408
18R:R:Y142 6.914528
19R:R:F143 2.84405
20R:R:F147 4.21426
21R:R:E197 7.685414
22R:R:F220 10.1275406
23R:R:F221 6.87408
24R:R:Y232 6.00667609
25R:R:L239 4.09428
26R:R:W276 5.715618
27R:R:F279 7.426516
28R:R:R283 7.32416
29R:R:L285 2.84404
30R:R:F286 7.0425414
31R:R:F290 4.755411
32R:R:N305 6.2775414
33R:R:F309 4.762515
34R:R:F312 5.74333617
35R:R:Y313 9.774517
36R:R:L322 2.676508
37R:R:Y323 5.0875449
38R:R:Y330 6.37833638
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:S2 R:R:S308 15.86366.52NoNo007
2L:L:?3 L:L:F4 30.9257.56YesNo000
3L:L:F4 R:R:F38 12.93216.43NoYes004
4L:L:?3 R:R:F286 48.144713.23YesYes104
5L:L:L5 R:R:F286 19.884.87YesYes104
6L:L:H9 L:L:L5 13.930421.86YesYes100
7R:R:F286 R:R:F290 16.29064.29YesYes141
8L:L:H9 R:R:F290 13.04174.53YesYes101
9L:L:F4 R:R:L103 26.64324.87NoNo004
10R:R:F309 R:R:L103 40.10043.65YesNo054
11R:R:D99 R:R:F309 14.21894.78NoYes165
12R:R:D99 R:R:F119 69.21924.78NoYes164
13R:R:F119 R:R:R102 33.86239.62YesYes145
14R:R:R102 R:R:Y106 34.46828.23YesYes153
15R:R:E197 R:R:Y106 29.19966.73YesYes143
16R:R:E197 R:R:R107 22.59224.65YesNo044
17L:L:E8 R:R:R107 16.56764.65NoNo004
18L:L:E8 L:L:R11 12.493517.45NoNo000
19L:L:H9 L:L:Q13 14.11516.18YesNo000
20L:L:H9 L:L:Q10 10.77962.47YesNo000
21L:L:R11 L:L:V12 10.43917.85NoNo000
22L:L:K16 L:L:Q13 11.10855.42NoNo000
23R:R:L103 R:R:L43 17.72754.15NoYes045
24R:R:F309 R:R:Y313 31.634810.32YesYes157
25R:R:F93 R:R:Y313 66.01655.16YesYes167
26R:R:F93 R:R:L53 14.49592.44YesNo067
27R:R:L314 R:R:L53 13.06484.15NoNo057
28L:L:?3 R:R:R283 54.24438.48YesYes106
29R:R:F279 R:R:R283 55.40428.55YesYes166
30R:R:F279 R:R:F312 25.11975.36YesYes167
31R:R:F312 R:R:Y313 67.915113.41YesYes177
32R:R:F54 R:R:F93 10.10445.36NoYes076
33R:R:A316 R:R:F93 54.53294.16NoYes096
34R:R:A316 R:R:D89 53.81154.63NoYes099
35R:R:D89 R:R:N61 10.676.73YesNo099
36R:R:F279 R:R:W276 56.662210.02YesYes168
37R:R:F272 R:R:W276 1009.02NoYes098
38R:R:F272 R:R:L228 99.67684.87NoNo098
39R:R:I134 R:R:L228 59.61114.28YesNo088
40R:R:I134 R:R:Y323 65.54333.63YesYes089
41R:R:L82 R:R:Y323 33.10645.86NoYes489
42R:R:L82 R:R:N324 33.51035.49NoNo087
43R:R:N324 R:R:Y330 29.655519.77NoYes078
44R:R:D89 R:R:T130 37.07664.34YesNo099
45R:R:S88 R:R:T130 35.11454.8NoNo089
46R:R:C126 R:R:S88 10.675.16NoNo088
47R:R:L137 R:R:Y323 44.19184.69NoYes489
48R:R:L137 R:R:Y81 44.70544.69NoYes088
49R:R:E140 R:R:Y81 22.34988.98NoYes098
50R:R:E140 R:R:T78 16.55618.47NoNo098
51R:R:T76 R:R:T78 14.53631.57NoNo078
52R:R:N79 R:R:T76 12.49357.31NoNo087
53R:R:N79 R:R:V68 10.43915.91NoNo087
54R:R:L74 R:R:Y330 16.15212.34NoYes088
55R:R:E73 R:R:L74 12.0783.98NoNo068
56R:R:E73 R:R:F71 10.02374.66NoNo065
57R:R:S88 R:R:W168 23.16.18NoNo089
58R:R:I134 R:R:N319 37.03624.25YesNo089
59R:R:F119 R:R:W109 25.45444.01YesYes147
60R:R:V184 R:R:W109 14.2942.45NoYes057
61R:R:F172 R:R:W168 16.93696.01NoNo049
62R:R:F121 R:R:F172 12.77057.5NoNo064
63R:R:T127 R:R:Y128 14.96913.75NoYes076
64R:R:F220 R:R:Y128 14.951827.85YesYes066
65R:R:L228 R:R:Y232 62.00014.69NoYes089
66R:R:S138 R:R:Y232 49.35087.63NoYes099
67R:R:L231 R:R:S138 47.79854.5NoNo079
68R:R:R141 R:R:Y232 14.507510.29NoYes099
69R:R:L231 R:R:Y142 46.234612.89NoYes078
70R:R:F147 R:R:Y142 12.65514.13YesYes268
71R:R:L234 R:R:Y142 11.06825.86NoYes058
72R:R:I235 R:R:Y142 21.55923.63NoYes288
73R:R:F286 R:R:P200 14.7965.78YesNo044
74R:R:L210 R:R:P200 12.83973.28NoNo034
75R:R:L181 R:R:L210 10.72774.15NoNo043
76R:R:N196 R:R:V184 10.2664.43NoNo045
77R:R:F279 R:R:H280 15.6277.92YesNo067
78R:R:F221 R:R:H280 15.90976.79YesNo087
79R:R:V269 R:R:Y232 12.79945.05NoYes089
80R:R:I235 R:R:L239 16.17522.85NoYes288
81R:R:H258 R:R:L239 12.88017.71NoYes268
82R:R:V268 R:R:Y232 19.66072.52NoYes089
83R:R:L322 R:R:V268 18.51814.47YesNo088
84R:R:I321 R:R:L322 17.60061.43NoYes068
85R:R:I321 R:R:I325 15.67312.94NoNo066
86R:R:I325 R:R:M326 13.73422.92NoNo067
87R:R:M264 R:R:M326 11.78372.89NoNo087
88L:L:?3 R:R:N305 25.20059.59YesYes104
89R:R:N305 R:R:S301 32.49474.47YesNo044
90R:R:L285 R:R:S301 29.59783YesNo044
91R:R:L285 R:R:Y284 17.89492.34YesNo045
92R:R:K288 R:R:Y284 14.94037.17NoNo045
93R:R:V154 R:R:V155 12.40693.21NoNo047
94R:R:I318 R:R:L314 12.18191.43NoNo075
95R:R:D99 R:R:Y313 56.47769.2NoYes167
96R:R:F279 R:R:S308 20.01855.28YesNo067
97L:L:S2 R:R:N305 13.04755.96NoYes104
98R:R:D89 R:R:N319 36.49954.04YesNo099
99R:R:I318 R:R:L322 11.39131.43NoYes078
100R:R:F312 R:R:W276 39.69074.01YesYes178
101R:R:R141 R:R:Y323 13.74576.17NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:S2 R:R:N305 5.96 1 No Yes 0 4 0 1
L:L:S2 R:R:S308 6.52 1 No No 0 7 0 1
L:L:?3 R:R:E124 4.11 1 Yes Yes 0 4 0 1
L:L:?3 R:R:V214 4.62 1 Yes No 0 5 0 1
L:L:?3 R:R:R283 8.48 1 Yes Yes 0 6 0 1
L:L:?3 R:R:F286 13.23 1 Yes Yes 0 4 0 1
L:L:?3 R:R:N305 9.59 1 Yes Yes 0 4 0 1
L:L:F4 R:R:F38 6.43 0 No Yes 0 4 0 1
L:L:F4 R:R:L103 4.87 0 No No 0 4 0 1
L:L:L5 R:R:F286 4.87 1 Yes Yes 0 4 0 1
L:L:L5 R:R:S289 7.51 1 Yes No 0 2 0 1
L:L:L5 R:R:F290 3.65 1 Yes Yes 0 1 0 1
L:L:L5 R:R:Q302 5.32 1 Yes No 0 3 0 1
L:L:S6 R:R:Y106 5.09 1 No Yes 0 3 0 1
L:L:S6 R:R:E197 10.06 1 No Yes 0 4 0 1
L:L:P7 R:R:Y106 5.56 1 No Yes 0 3 0 1
L:L:E8 R:R:Q36 3.82 0 No No 0 5 0 1
L:L:E8 R:R:R107 4.65 0 No No 0 4 0 1
L:L:H9 R:R:S289 4.18 1 Yes No 0 2 0 1
L:L:H9 R:R:F290 4.53 1 Yes Yes 0 1 0 1
L:L:Q10 R:R:L295 9.32 0 No No 0 7 0 1
L:L:R15 R:R:E187 4.65 0 No No 0 3 0 1
L:L:K16 R:R:E202 4.05 0 No No 0 6 0 1
R:R:F38 R:R:L37 8.53 0 Yes No 4 5 1 2
R:R:L37 R:R:Q302 3.99 0 No No 5 3 2 1
R:R:F38 R:R:L43 6.09 0 Yes Yes 4 5 1 2
R:R:F38 R:R:Y303 7.22 0 Yes No 4 1 1 2
R:R:F38 R:R:L306 14.61 0 Yes No 4 4 1 2
R:R:L103 R:R:L43 4.15 0 No Yes 4 5 1 2
R:R:F312 R:R:I92 6.28 1 Yes No 7 7 1 2
R:R:C95 R:R:S123 3.44 0 No No 6 6 2 1
R:R:R102 R:R:Y106 8.23 1 Yes Yes 5 3 2 1
R:R:F309 R:R:L103 3.65 1 Yes No 5 4 2 1
R:R:E197 R:R:Y106 6.73 1 Yes Yes 4 3 1 1
R:R:P108 R:R:R107 8.65 0 No No 4 4 2 1
R:R:E197 R:R:R107 4.65 1 Yes No 4 4 1 1
R:R:E124 R:R:Y128 5.61 1 Yes Yes 4 6 1 2
R:R:E124 R:R:I178 8.2 1 Yes No 4 4 1 2
R:R:E124 R:R:R283 6.98 1 Yes Yes 4 6 1 1
R:R:T127 R:R:Y128 3.75 1 No Yes 7 6 2 2
R:R:T127 R:R:W276 3.64 1 No Yes 7 8 2 2
R:R:F312 R:R:T127 3.89 1 Yes No 7 7 1 2
R:R:S217 R:R:Y128 3.82 0 No Yes 6 6 2 2
R:R:E187 R:R:T190 7.06 0 No No 3 3 1 2
R:R:E197 R:R:R199 9.3 1 Yes No 4 3 1 2
R:R:F286 R:R:P200 5.78 1 Yes No 4 4 1 2
R:R:F290 R:R:V205 6.55 1 Yes No 1 4 1 2
R:R:R283 R:R:S217 5.27 1 Yes No 6 6 1 2
R:R:F279 R:R:W276 10.02 1 Yes Yes 6 8 2 2
R:R:F312 R:R:W276 4.01 1 Yes Yes 7 8 1 2
R:R:F279 R:R:R283 8.55 1 Yes Yes 6 6 2 1
R:R:F279 R:R:S308 5.28 1 Yes No 6 7 2 1
R:R:F279 R:R:F312 5.36 1 Yes Yes 6 7 2 1
R:R:G282 R:R:N305 5.09 0 No Yes 4 4 2 1
R:R:F286 R:R:F290 4.29 1 Yes Yes 4 1 1 1
R:R:A298 R:R:S289 3.42 0 No No 3 2 2 1
R:R:Q299 R:R:Q302 7.68 0 No No 1 3 2 1
R:R:N305 R:R:S301 4.47 1 Yes No 4 4 1 2
R:R:F309 R:R:Y313 10.32 1 Yes Yes 5 7 2 2
R:R:F312 R:R:Y313 13.41 1 Yes Yes 7 7 1 2
R:R:S287 R:R:V214 3.23 0 No No 4 5 2 1
L:L:V12 R:R:E187 2.85 0 No No 0 3 0 1
L:L:G1 R:R:S123 1.86 0 No No 0 6 0 1
R:R:P278 R:R:S308 1.78 0 No No 9 7 2 1
L:L:G1 R:R:F312 1.51 0 No Yes 0 7 0 1
R:R:E202 R:R:N188 1.31 0 No No 6 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7W2Z_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.28
Number of Linked Nodes 300
Number of Links 324
Number of Hubs 38
Number of Links mediated by Hubs 146
Number of Communities 4
Number of Nodes involved in Communities 44
Number of Links involved in Communities 60
Path Summary
Number Of Nodes in MetaPath 102
Number Of Links MetaPath 101
Number of Shortest Paths 53244
Length Of Smallest Path 3
Average Path Length 12.5262
Length of Longest Path 28
Minimum Path Strength 1.155
Average Path Strength 6.07313
Maximum Path Strength 16.73
Minimum Path Correlation 0.7
Average Path Correlation 0.935455
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 56.2931
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.871
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • mu-type opioid receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cation binding   • metal ion binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • heart process   • multicellular organismal process   • system process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • behavior   • locomotory behavior   • transport   • secretion   • export from cell   • membrane docking   • establishment of localization   • vesicle-mediated transport   • localization   • organelle localization by membrane tethering   • secretion by cell   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • protein localization   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • cellular macromolecule localization   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • GABA-ergic synapse   • glutamatergic synapse   • cell body   • molecular transducer activity   • growth hormone secretagogue receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • amide binding   • binding   • peptide hormone binding   • hormone binding   • identical protein binding   • protein binding   • growth hormone-releasing hormone receptor activity   • multicellular organismal process   • system process   • regulation of biological process   • digestive system process   • regulation of system process   • regulation of gastric motility   • biological regulation   • regulation of digestive system process   • digestion   • gastric motility   • regulation of multicellular organismal process   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to insulin-like growth factor stimulus   • cellular response to hormone stimulus   • developmental process   • spermatogenesis   • sexual reproduction   • reproductive process   • multicellular organismal reproductive process   • developmental process involved in reproduction   • male gamete generation   • gamete generation   • regulation of tumor necrosis factor production   • regulation of cellular process   • negative regulation of biological process   • negative regulation of tumor necrosis factor production   • cytokine production   • regulation of cytokine production   • negative regulation of cellular process   • negative regulation of macromolecule metabolic process   • regulation of biosynthetic process   • negative regulation of metabolic process   • tumor necrosis factor superfamily cytokine production   • negative regulation of cytokine production   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • tumor necrosis factor production   • regulation of gene expression   • negative regulation of gene expression   • regulation of tumor necrosis factor superfamily cytokine production   • biosynthetic process   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of tumor necrosis factor superfamily cytokine production   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • negative regulation of multicellular organismal process   • regulation of metabolic process   • interleukin-6 production   • regulation of interleukin-6 production   • negative regulation of interleukin-6 production   • negative regulation of behavior   • negative regulation of locomotion   • locomotion involved in locomotory behavior   • behavior   • regulation of behavior   • negative regulation of locomotion involved in locomotory behavior   • locomotory behavior   • regulation of locomotion   • regulation of locomotion involved in locomotory behavior   • locomotion   • regulation of localization   • regulation of hormone secretion   • nitrogen compound transport   • regulation of peptide secretion   • signaling   • transport   • hormone secretion   • cell communication   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of biological quality   • regulation of peptide hormone secretion   • regulation of signaling   • growth hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of growth hormone secretion   • regulation of peptide transport   • export from cell   • cell-cell signaling   • establishment of localization   • regulation of secretion   • peptide transport   • peptide hormone secretion   • regulation of cell communication   • hormone transport   • intestinal motility   • positive regulation of small intestinal transit   • positive regulation of biological process   • positive regulation of digestive system process   • positive regulation of multicellular organismal process   • small intestinal transit   • regulation of small intestinal transit   • cell surface receptor signaling pathway   • insulin-like growth factor receptor signaling pathway   • cell surface receptor protein tyrosine kinase signaling pathway   • signal transduction   • enzyme-linked receptor protein signaling pathway   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of insulin-like growth factor receptor signaling pathway   • regulation of insulin-like growth factor receptor signaling pathway   • positive regulation of cellular process   • regulation of response to stimulus   • positive regulation of signaling   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • response to ketone   • response to lipid   • response to glucocorticoid   • response to corticosteroid   • response to steroid hormone   • response to dexamethasone   • cell population proliferation   • positive regulation of cell population proliferation   • endothelial cell proliferation   • positive regulation of epithelial cell proliferation   • regulation of vascular endothelial cell proliferation   • regulation of endothelial cell proliferation   • regulation of cell population proliferation   • positive regulation of endothelial cell proliferation   • regulation of epithelial cell proliferation   • vascular endothelial cell proliferation   • epithelial cell proliferation   • positive regulation of vascular endothelial cell proliferation   • response to growth hormone   • response to thyroid hormone   • cellular response to thyroid hormone stimulus   • response to acid chemical   • response to L-glutamate   • response to amino acid   • regulation of cellular component organization   • cellular component organization   • cellular component biogenesis   • multicellular organism development   • cellular component assembly   • cell junction assembly   • anatomical structure development   • regulation of synapse structure or activity   • regulation of synapse assembly   • synapse organization   • cellular component organization or biogenesis   • system development   • nervous system development   • regulation of cellular component biogenesis   • regulation of cell junction assembly   • regulation of synapse organization   • cell junction organization   • synapse assembly   • response to gonadotropin   • response to follicle-stimulating hormone   • postsynapse organization   • regulation of postsynapse organization   • regulation of hindgut contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • hindgut contraction   • smooth muscle contraction   • regulation of smooth muscle contraction   • regulation of muscle contraction   • adult feeding behavior   • adult behavior   • feeding behavior   • actin polymerization or depolymerization   • organelle organization   • actin cytoskeleton organization   • actin filament organization   • actin filament-based process   • supramolecular fiber organization   • cytoskeleton organization   • positive regulation of smooth muscle contraction   • intestine smooth muscle contraction   • regulation of gastro-intestinal system smooth muscle contraction   • positive regulation of small intestine smooth muscle contraction   • regulation of small intestine smooth muscle contraction   • small intestine smooth muscle contraction   • gastro-intestinal system smooth muscle contraction   • phasic smooth muscle contraction   • positive regulation of gastro-intestinal system smooth muscle contraction   • positive regulation of muscle contraction   • leukocyte apoptotic process   • regulation of programmed cell death   • macrophage apoptotic process   • negative regulation of leukocyte apoptotic process   • myeloid cell apoptotic process   • regulation of leukocyte apoptotic process   • negative regulation of programmed cell death   • regulation of apoptotic process   • negative regulation of macrophage apoptotic process   • cell death   • negative regulation of apoptotic process   • regulation of macrophage apoptotic process   • inflammatory cell apoptotic process   • negative regulation of myeloid cell apoptotic process   • apoptotic process   • regulation of myeloid cell apoptotic process   • programmed cell death   • response to nutrient levels   • regulation of response to nutrient levels   • negative regulation of response to food   • negative regulation of response to nutrient levels   • negative regulation of response to stimulus   • negative regulation of appetite   • regulation of response to food   • response to food   • regulation of appetite   • oxoacid metabolic process   • ketone metabolic process   • regulation of lipid metabolic process   • organic acid metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • positive regulation of fatty acid metabolic process   • fatty acid metabolic process   • carboxylic acid metabolic process   • primary metabolic process   • regulation of ketone metabolic process   • regulation of fatty acid metabolic process   • monocarboxylic acid metabolic process   • positive regulation of small molecule metabolic process   • lipid metabolic process   • hormone-mediated signaling pathway   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • defense response   • response to external stimulus   • regulation of inflammatory response   • response to stress   • negative regulation of response to external stimulus   • regulation of response to stress   • negative regulation of defense response   • inflammatory response   • interleukin-1 production   • regulation of interleukin-1 beta production   • negative regulation of interleukin-1 beta production   • negative regulation of interleukin-1 production   • regulation of interleukin-1 production   • interleukin-1 beta production   • biological process involved in interspecies interaction between organisms   • response to other organism   • cellular response to lipopolysaccharide   • cellular response to molecule of bacterial origin   • response to lipopolysaccharide   • response to biotic stimulus   • cellular response to biotic stimulus   • response to bacterium   • cellular response to lipid   • response to external biotic stimulus   • response to molecule of bacterial origin   • positive regulation of appetite   • positive regulation of response to food   • positive regulation of response to nutrient levels   • protein localization   • negative regulation of protein transport   • establishment of protein localization   • negative regulation of transport   • negative regulation of secretion   • cellular macromolecule localization   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • negative regulation of protein secretion   • cellular localization   • regulation of protein localization   • negative regulation of signaling   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • negative regulation of protein localization   • regulation of establishment of protein localization   • regulation of protein transport   • negative regulation of insulin secretion   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • macromolecule localization   • insulin secretion   • ghrelin secretion   • protein localization to synapse   • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane   • regulation of protein localization to synapse   • neurotransmitter receptor localization to postsynaptic specialization membrane   • regulation of protein localization to membrane   • regulation of receptor localization to synapse   • protein localization to postsynaptic specialization membrane   • protein localization to cell periphery   • protein localization to postsynaptic membrane   • regulation of protein localization to cell periphery   • localization within membrane   • protein localization to membrane   • protein-containing complex localization   • regulation of postsynaptic membrane neurotransmitter receptor levels   • protein localization to organelle   • protein localization to postsynapse   • protein localization to cell junction   • receptor localization to synapse   • multi-multicellular organism process   • placenta development   • maternal process involved in female pregnancy   • animal organ development   • tissue development   • maternal placenta development   • female pregnancy   • multi-organism reproductive process   • decidualization   • learning or memory   • nervous system process   • cognition   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • regulation of developmental process   • developmental growth   • growth   • positive regulation of multicellular organism growth   • positive regulation of developmental process   • multicellular organism growth   • positive regulation of growth   • positive regulation of developmental growth   • regulation of sprouting angiogenesis   • angiogenesis   • regulation of vasculature development   • tube morphogenesis   • positive regulation of sprouting angiogenesis   • regulation of anatomical structure morphogenesis   • blood vessel development   • regulation of multicellular organismal development   • blood vessel morphogenesis   • tube development   • positive regulation of angiogenesis   • sprouting angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • anatomical structure formation involved in morphogenesis   • regulation of eating behavior   • positive regulation of feeding behavior   • eating behavior   • positive regulation of eating behavior   • positive regulation of behavior   • regulation of feeding behavior   • response to insulin   • cellular response to insulin stimulus   • G protein-coupled receptor signaling pathway   • monoamine transport   • negative regulation of amine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • catecholamine transport   • negative regulation of norepinephrine secretion   • norepinephrine transport   • negative regulation of catecholamine secretion   • organic cation transport   • catecholamine secretion   • amine transport   • norepinephrine secretion   • regulation of amine transport   • regulation of norepinephrine secretion   • transmission of nerve impulse   • regulation of nervous system process   • regulation of transmission of nerve impulse   • response to estradiol   • cell surface   • membrane microdomain   • membrane raft   • Schaffer collateral - CA1 synapse   • G-protein beta-subunit binding   • fibroblast proliferation   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to prostaglandin   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to prostaglandin E   • cellular response to ketone   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • protein tyrosine kinase activator activity   • enzyme regulator activity   • catalytic activity, acting on a protein   • molecular function activator activity   • kinase activity   • protein kinase activity   • transferase activity   • protein kinase regulator activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • kinase activator activity   • enzyme activator activity   • protein tyrosine kinase activity   • molecular function regulator activity   • protein kinase activator activity   • kinase regulator activity   • ghrelin receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • growth hormone-releasing hormone activity   • signaling receptor activator activity   • hormone activity   • signaling receptor regulator activity   • receptor ligand activity   • skeletal system development   • connective tissue development   • cartilage development   • positive regulation of blood circulation   • gastric mucosal blood circulation   • regulation of gastric mucosal blood circulation   • circulatory system process   • regulation of blood circulation   • positive regulation of gastric mucosal blood circulation   • blood circulation   • regulation of circadian sleep/wake cycle   • negative regulation of circadian sleep/wake cycle, REM sleep   • regulation of circadian rhythm   • sleep   • circadian sleep/wake cycle, sleep   • rhythmic process   • circadian sleep/wake cycle   • rhythmic behavior   • circadian rhythm   • regulation of circadian sleep/wake cycle, REM sleep   • negative regulation of circadian sleep/wake cycle, sleep   • negative regulation of circadian rhythm   • circadian behavior   • circadian sleep/wake cycle, REM sleep   • regulation of circadian sleep/wake cycle, sleep   • circadian sleep/wake cycle process   • regulation of bone development   • positive regulation of bone development   • bone development   • positive regulation of growth rate   • regulation of growth rate   • monosaccharide metabolic process   • carbohydrate metabolic process   • hexose metabolic process   • glucose metabolic process   • response to electrical stimulus   • response to abiotic stimulus   • positive regulation of corticotropin secretion   • positive regulation of peptide hormone secretion   • endocrine hormone secretion   • regulation of endocrine process   • positive regulation of secretion by cell   • regulation of corticotropin secretion   • positive regulation of hormone secretion   • positive regulation of secretion   • positive regulation of peptide secretion   • corticotropin secretion   • endocrine process   • positive regulation of transport   • steroid hormone secretion   • cortisol secretion   • lipid localization   • lipid transport   • lipid export from cell   • glucocorticoid secretion   • corticosteroid hormone secretion   • cellular response to growth hormone stimulus   • regulation of growth hormone receptor signaling pathway   • growth hormone receptor signaling pathway   • positive regulation of growth hormone receptor signaling pathway   • positive regulation of steroid hormone secretion   • regulation of glucocorticoid secretion   • positive regulation of cortisol secretion   • positive regulation of glucocorticoid secretion   • regulation of steroid hormone secretion   • positive regulation of corticosteroid hormone secretion   • regulation of corticosteroid hormone secretion   • positive regulation of lipid transport   • regulation of cortisol secretion   • regulation of lipid transport   • positive regulation of lipid localization   • regulation of lipid localization   • acid secretion   • gastric acid secretion   • positive regulation of cytosolic calcium ion concentration   • positive regulation of nervous system development   • positive regulation of cellular component organization   • regulation of nervous system development   • positive regulation of cellular component biogenesis   • positive regulation of cell junction assembly   • positive regulation of synapse assembly   • response to estrogen   • adipose tissue development   • positive regulation of adipose tissue development   • regulation of adipose tissue development   • regulation of circadian sleep/wake cycle, non-REM sleep   • circadian sleep/wake cycle, non-REM sleep   • positive regulation of circadian sleep/wake cycle, non-REM sleep   • positive regulation of circadian rhythm   • positive regulation of circadian sleep/wake cycle, sleep   • regulation of postsynaptic membrane potential   • chemical synaptic transmission, postsynaptic   • excitatory postsynaptic potential   • regulation of membrane potential   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of establishment of protein localization   • carbohydrate homeostasis   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular glucose homeostasis   • cellular response to carbohydrate stimulus   • chemical homeostasis   • response to glucose   • glucose homeostasis   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • positive regulation of protein transport   • response to monosaccharide   • response to carbohydrate   • cellular response to hexose stimulus   • intracellular chemical homeostasis   • cellular response to monosaccharide stimulus   • cellular response to glucose stimulus   • positive regulation of protein secretion   • response to hexose   • cellular homeostasis   • regulation of insulin secretion involved in cellular response to glucose stimulus   • regulation of intracellular signal transduction   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • MAPK cascade   • plasma membrane bounded cell projection organization   • cellular developmental process   • cell projection organization   • cell development   • neuron projection development   • generation of neurons   • neurogenesis   • neuron differentiation   • dendrite development   • cell differentiation   • neuron development   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • positive regulation of growth hormone secretion   • negative regulation of cell population proliferation   • negative regulation of endothelial cell proliferation   • negative regulation of epithelial cell proliferation   • membrane-enclosed lumen   • endomembrane system   • intracellular organelle lumen   • endoplasmic reticulum lumen   • organelle lumen   • endoplasmic reticulum   • axon   • intracellular vesicle   • cytoplasmic vesicle lumen   • cytoplasmic vesicle   • neuronal dense core vesicle lumen   • neuronal dense core vesicle   • vesicle lumen   • dense core granule   • secretory granule lumen   • secretory granule   • dense core granule lumen   • secretory vesicle
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeK4Q
PDB ResiduesL:L:?3
Environment DetailsOpen EMBL-EBI Page
CodeK4Q
Name[(2~{S})-2-azanyl-3-oxidanylidene-propyl] octanoate
Synonyms
Identifier
FormulaC11 H21 N O3
Molecular Weight215.289
SMILES
PubChem155312307
Formal Charge0
Total Atoms36
Total Chiral Atoms1
Total Bonds35
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ92847
Sequence
>7W2Z_nogp_Chain_R
LQLFPAPLL AGVTATCVA LFVVGIAGN LLTMLVVSR FRELRTTTN 
LYLSSMAFS DLLIFLCMP LDLVRLWQY RPWNFGDLL CKLFQFVSE 
SCTYATVLT ITALSVERY FAICFPLRA KVVVTKGRV KLVIFVIWA 
VAFCSAGPI FVLVGVEHE NGTDPWDTN ECRPTEFAV RSGLLTVMV 
WVSSIFFFL PVFCLTVLY SLIGRKLWR RRRGSLRDQ NHKQTVKML 
AVVVFAFIL CWLPFHVGR YLFSKSFEP GSLEIAQIS QYCNLVSFV 
LFYLSAAIN PILYNIMSK KYRVAVFRL LGFE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JSRAPeptideGhrelinGhrelinHomo sapiensAnamorelin-chim(NtGi1-Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1038/s41594-024-01481-6
8JSR (No Gprot) APeptideGhrelinGhrelinHomo sapiensAnamorelin-2.92025-01-22doi.org/10.1038/s41594-024-01481-6
7F83APeptideGhrelinGhrelinHomo sapiensPF-05190457--2.942022-01-1910.1038/s41467-022-27975-9
7W2ZAPeptideGhrelinGhrelinHomo sapiensGhrelin-Go/β1/γ22.82022-01-1910.1038/s41467-022-27975-9
7W2Z (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-2.82022-01-1910.1038/s41467-022-27975-9
7NA8APeptideGhrelinGhrelinHomo sapiensPubChem 178024-Gi1/β1/γ22.72021-12-1510.1038/s41467-021-26735-5
7NA8 (No Gprot) APeptideGhrelinGhrelinHomo sapiensPubChem 178024-2.72021-12-1510.1038/s41467-021-26735-5
7NA7APeptideGhrelinGhrelinHomo sapiensGhrelin-27-Gi1/β1/γ22.72021-12-1510.1038/s41467-021-26735-5
7NA7 (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-27-2.72021-12-1510.1038/s41467-021-26735-5
7F9ZAPeptideGhrelinGhrelinHomo sapiensGHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ23.22021-08-1810.1038/s41467-021-25364-2
7F9Z (No Gprot) APeptideGhrelinGhrelinHomo sapiensGHRP-6-3.22021-08-1810.1038/s41467-021-25364-2
7F9YAPeptideGhrelinGhrelinHomo sapiensGhrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ22.92021-08-1810.1038/s41467-021-25364-2
7F9Y (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-28-2.92021-08-1810.1038/s41467-021-25364-2
6KO5APeptideGhrelinGhrelinHomo sapiensPubChem 57400002--3.32020-08-1210.1038/s41467-020-17554-1




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