psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G2	R:R:S123	3.71	No	No	0	0	6
2	L:L:F5	L:L:S3	3.96	Yes	No	0	0	0
3	L:L:S4	R:R:F286	10.57	No	Yes	0	0	4
4	L:L:?1	L:L:S4	12.86	Yes	No	0	0	0
5	L:L:F5	R:R:F38	3.22	Yes	Yes	2	0	4
6	L:L:F5	R:R:R102	6.41	Yes	No	0	0	5
7	L:L:F5	R:R:Q302	3.51	Yes	Yes	2	0	3
8	L:L:F5	R:R:N305	3.62	Yes	No	0	0	4
9	L:L:F5	R:R:F309	5.36	Yes	No	0	0	5
10	L:L:H10	L:L:L6	11.57	No	Yes	2	0	0
11	L:L:L6	R:R:F286	4.87	Yes	Yes	2	0	4
12	L:L:L6	R:R:S289	9.01	Yes	No	2	0	2
13	L:L:L6	R:R:F290	3.65	Yes	Yes	2	0	1
14	L:L:L6	R:R:Q302	5.32	Yes	Yes	2	0	3
15	L:L:S7	R:R:Y106	8.9	No	No	5	0	3
16	L:L:S7	R:R:E197	4.31	No	No	5	0	4
17	L:L:P8	R:R:Q36	6.32	No	No	0	0	5
18	L:L:P8	R:R:L37	13.14	No	No	0	0	5
19	L:L:P8	R:R:Y106	9.74	No	No	0	0	3
20	L:L:E9	L:L:R12	4.65	No	No	0	0	0
21	L:L:H10	L:L:Q14	9.89	No	No	0	0	0
22	L:L:H10	R:R:F290	7.92	No	Yes	2	0	1
23	L:L:Q11	R:R:Q299	3.84	No	No	0	0	1
24	L:L:Q15	L:L:R12	9.35	No	No	0	0	0
25	L:L:Q14	L:L:V13	5.73	No	No	0	0	0
26	R:R:F38	R:R:L37	4.87	Yes	No	2	4	5
27	R:R:L37	R:R:Q302	3.99	No	Yes	2	5	3
28	R:R:F38	R:R:Q302	9.37	Yes	Yes	2	4	3
29	R:R:F38	R:R:L306	13.4	Yes	No	0	4	4
30	R:R:L306	R:R:L42	4.15	No	No	0	4	3
31	R:R:L43	R:R:W104	23.92	No	No	0	5	4
32	R:R:L100	R:R:T47	5.9	No	No	0	7	6
33	R:R:T47	R:R:W104	9.7	No	No	0	6	4
34	R:R:C50	R:R:M96	3.24	No	Yes	0	6	7
35	R:R:L314	R:R:L53	4.15	No	No	0	5	7
36	R:R:F54	R:R:I58	11.3	Yes	Yes	3	7	6
37	R:R:F54	R:R:F93	3.22	Yes	Yes	3	7	6
38	R:R:F54	R:R:M96	7.46	Yes	Yes	0	7	7
39	R:R:F93	R:R:G57	4.52	Yes	No	0	6	8
40	R:R:F93	R:R:I58	7.54	Yes	Yes	3	6	6
41	R:R:A86	R:R:N61	4.69	No	Yes	0	9	9
42	R:R:D89	R:R:N61	6.73	No	Yes	0	9	9
43	R:R:F93	R:R:N61	3.62	Yes	Yes	0	6	9
44	R:R:N61	R:R:P320	11.4	Yes	No	0	9	9
45	R:R:L62	R:R:L90	5.54	No	No	3	3	7
46	R:R:L63	R:R:Y330	3.52	No	Yes	0	6	8
47	R:R:A86	R:R:T64	3.36	No	No	0	9	9
48	R:R:N324	R:R:T64	7.31	No	No	6	7	9
49	R:R:T64	R:R:Y330	7.49	No	Yes	6	9	8
50	R:R:N79	R:R:V68	5.91	No	No	0	8	7
51	R:R:F71	R:R:L74	4.87	No	No	0	5	8
52	R:R:L74	R:R:N79	4.12	No	No	0	8	8
53	R:R:A333	R:R:L74	4.73	No	No	0	6	8
54	R:R:K157	R:R:R75	4.95	Yes	No	0	3	7
55	R:R:T76	R:R:T77	3.14	No	No	0	7	7
56	R:R:T76	R:R:T78	6.28	No	No	0	7	8
57	R:R:N79	R:R:T76	5.85	No	No	0	8	7
58	R:R:E140	R:R:T77	9.88	Yes	No	0	9	7
59	R:R:T77	R:R:V160	3.17	No	No	0	7	7
60	R:R:E140	R:R:T78	4.23	Yes	No	0	9	8
61	R:R:A136	R:R:Y81	4	No	Yes	0	7	8
62	R:R:E140	R:R:Y81	6.73	Yes	Yes	0	9	8
63	R:R:V160	R:R:Y81	12.62	No	Yes	0	7	8
64	R:R:V163	R:R:Y81	7.57	No	Yes	0	6	8
65	R:R:I164	R:R:Y81	3.63	No	Yes	0	7	8
66	R:R:L82	R:R:Y323	7.03	No	Yes	0	8	9
67	R:R:L82	R:R:N324	5.49	No	No	0	8	7
68	R:R:S84	R:R:W168	4.94	No	Yes	0	9	9
69	R:R:M85	R:R:T133	6.02	No	No	0	9	8
70	R:R:I134	R:R:M85	4.37	No	No	0	8	9
71	R:R:M85	R:R:N319	5.61	No	No	0	9	9
72	R:R:C126	R:R:S88	3.44	Yes	No	0	8	8
73	R:R:S88	R:R:T130	4.8	No	No	0	8	9
74	R:R:S88	R:R:W168	3.71	No	Yes	0	8	9
75	R:R:A316	R:R:D89	4.63	No	No	0	9	9
76	R:R:D89	R:R:N319	8.08	No	No	0	9	9
77	R:R:F93	R:R:I92	3.77	Yes	No	0	6	7
78	R:R:C126	R:R:I92	4.91	Yes	No	0	8	7
79	R:R:F312	R:R:I92	6.28	No	No	0	7	7
80	R:R:F93	R:R:Y313	6.19	Yes	Yes	0	6	7
81	R:R:A316	R:R:F93	5.55	No	Yes	0	9	6
82	R:R:C95	R:R:V122	3.42	No	No	0	6	5
83	R:R:M96	R:R:P97	3.35	Yes	No	0	7	7
84	R:R:M96	R:R:Y313	15.57	Yes	Yes	0	7	7
85	R:R:F111	R:R:L98	4.87	Yes	No	0	6	5
86	R:R:F119	R:R:L98	15.83	Yes	No	0	4	5
87	R:R:D99	R:R:F119	4.78	No	Yes	0	6	4
88	R:R:D99	R:R:Y313	3.45	No	Yes	0	6	7
89	R:R:Q120	R:R:R102	3.5	Yes	No	0	4	5
90	R:R:Q105	R:R:R107	18.69	No	No	0	4	4
91	R:R:E197	R:R:Y106	15.71	No	No	5	4	3
92	R:R:F111	R:R:W109	17.04	Yes	Yes	0	6	7
93	R:R:C116	R:R:W109	3.92	No	Yes	7	9	7
94	R:R:F119	R:R:W109	4.01	Yes	Yes	0	4	7
95	R:R:V184	R:R:W109	3.68	No	Yes	0	5	7
96	R:R:C198	R:R:W109	11.75	No	Yes	7	9	7
97	R:R:F111	R:R:L115	3.65	Yes	No	0	6	5
98	R:R:C116	R:R:D113	3.11	No	Yes	0	9	4
99	R:R:D113	R:R:K117	8.3	Yes	No	0	4	7
100	R:R:D113	R:R:G183	5.03	Yes	No	0	4	4
101	R:R:D113	R:R:V184	8.76	Yes	No	0	4	5
102	R:R:F119	R:R:L115	3.65	Yes	No	0	4	5
103	R:R:C116	R:R:C198	7.28	No	No	7	9	9
104	R:R:F179	R:R:K117	4.96	No	No	0	5	7
105	R:R:F119	R:R:Q120	3.51	Yes	Yes	0	4	4
106	R:R:Q120	R:R:V182	8.6	Yes	No	0	4	4
107	L:L:?1	R:R:Q120	10.13	Yes	Yes	0	0	4
108	R:R:F121	R:R:S125	10.57	Yes	No	8	6	5
109	R:R:F121	R:R:F172	7.5	Yes	No	8	6	4
110	R:R:F121	R:R:F179	12.86	Yes	No	0	6	5
111	R:R:E124	R:R:Y128	15.71	Yes	Yes	1	4	6
112	R:R:E124	R:R:I178	5.47	Yes	No	1	4	4
113	R:R:E124	R:R:R283	10.47	Yes	Yes	1	4	6
114	L:L:?1	R:R:E124	10.09	Yes	Yes	1	0	4
115	R:R:F172	R:R:S125	5.28	No	No	8	4	5
116	R:R:A175	R:R:S125	3.42	No	No	0	7	5
117	R:R:T127	R:R:W276	7.28	No	Yes	1	7	8
118	R:R:F312	R:R:T127	9.08	No	No	1	7	7
119	R:R:S174	R:R:Y128	8.9	No	Yes	1	5	6
120	R:R:S217	R:R:Y128	7.63	No	Yes	0	6	6
121	R:R:F220	R:R:Y128	11.35	Yes	Yes	1	6	6
122	R:R:A129	R:R:W168	7.78	No	Yes	0	6	9
123	R:R:P224	R:R:V131	3.53	No	No	0	9	8
124	R:R:F272	R:R:V131	5.24	No	No	1	9	8
125	R:R:V131	R:R:W276	3.68	No	Yes	1	8	8
126	R:R:I167	R:R:L132	9.99	No	No	0	7	6
127	R:R:F220	R:R:L132	10.96	Yes	No	0	6	6
128	R:R:I134	R:R:Y323	3.63	No	Yes	0	8	9
129	R:R:P224	R:R:T135	3.5	No	No	0	9	7
130	R:R:C227	R:R:T135	3.38	No	No	0	6	7
131	R:R:L137	R:R:Y323	5.86	No	Yes	0	8	9
132	R:R:S138	R:R:Y232	5.09	No	Yes	0	9	9
133	R:R:E140	R:R:V155	7.13	Yes	No	0	9	7
134	R:R:R141	R:R:Y232	4.12	No	Yes	0	9	9
135	R:R:R141	R:R:Y323	6.17	No	Yes	0	9	9
136	R:R:C146	R:R:Y142	9.41	No	Yes	0	7	8
137	R:R:L231	R:R:Y142	15.24	No	Yes	0	7	8
138	R:R:L234	R:R:Y142	8.21	No	Yes	0	5	8
139	R:R:I235	R:R:Y142	3.63	No	Yes	0	8	8
140	R:R:F143	R:R:V154	7.87	No	No	0	5	4
141	R:R:I145	R:R:I235	4.42	No	No	0	9	8
142	R:R:I145	R:R:L239	4.28	No	No	0	9	8
143	R:R:C146	R:R:F147	4.19	No	No	0	7	6
144	R:R:C146	R:R:K238	4.85	No	No	0	7	5
145	R:R:R159	R:R:T156	11.64	No	No	0	5	7
146	R:R:F172	R:R:W168	10.02	No	Yes	0	4	9
147	R:R:F220	R:R:S174	3.96	Yes	No	1	6	5
148	R:R:G176	R:R:P177	4.06	No	No	0	4	7
149	R:R:P177	R:R:V212	3.53	No	No	0	7	6
150	L:L:?1	R:R:I178	9.51	Yes	No	1	0	4
151	R:R:L181	R:R:L209	4.15	No	Yes	0	4	4
152	R:R:L181	R:R:M213	4.24	No	No	0	4	5
153	R:R:G183	R:R:V182	3.68	No	No	0	4	4
154	R:R:N196	R:R:V184	5.91	No	No	0	4	5
155	R:R:H186	R:R:P192	15.25	No	No	0	2	1
156	R:R:E187	R:R:T190	5.64	No	Yes	4	3	3
157	R:R:E187	R:R:T195	9.88	No	No	4	3	3
158	R:R:T190	R:R:T195	4.71	Yes	No	4	3	3
159	R:R:D191	R:R:P192	8.05	Yes	No	0	6	1
160	R:R:D191	R:R:W193	11.17	Yes	No	0	6	4
161	R:R:D191	R:R:D194	6.65	Yes	No	4	6	5
162	R:R:N196	R:R:P192	3.26	No	No	0	4	1
163	R:R:E197	R:R:R199	5.82	No	No	0	4	3
164	R:R:F290	R:R:R199	3.21	Yes	No	0	1	3
165	R:R:F286	R:R:P200	4.33	Yes	No	0	4	4
166	R:R:F203	R:R:T201	3.89	No	No	0	6	3
167	R:R:E202	R:R:V205	5.7	No	No	0	6	4
168	R:R:F203	R:R:R206	5.34	No	No	0	6	1
169	R:R:A204	R:R:L209	3.15	No	Yes	0	4	4
170	R:R:F290	R:R:V205	11.8	Yes	No	0	1	4
171	R:R:G208	R:R:S207	3.71	No	No	0	2	3
172	R:R:L209	R:R:S207	6.01	Yes	No	0	4	3
173	R:R:T211	R:R:W215	6.06	No	No	0	4	4
174	R:R:V212	R:R:V216	3.21	No	No	0	6	5
175	L:L:?1	R:R:M213	5.38	Yes	No	0	0	5
176	R:R:V214	R:R:Y284	3.79	No	No	0	5	5
177	R:R:S287	R:R:V214	4.85	No	No	0	4	5
178	R:R:W215	R:R:Y284	3.86	No	No	0	4	5
179	R:R:R283	R:R:S217	7.91	Yes	No	0	6	6
180	R:R:F222	R:R:S218	7.93	No	No	0	4	4
181	R:R:F221	R:R:F222	4.29	No	No	0	8	4
182	R:R:F221	R:R:L277	3.65	No	No	0	8	6
183	R:R:F221	R:R:H280	16.97	No	No	0	8	7
184	R:R:F222	R:R:F226	5.36	No	No	0	4	3
185	R:R:L223	R:R:P224	3.28	No	No	0	5	9
186	R:R:C227	R:R:L223	3.17	No	No	0	6	5
187	R:R:L228	R:R:Y232	10.55	No	Yes	0	8	9
188	R:R:L265	R:R:Y232	10.55	No	Yes	0	8	9
189	R:R:V269	R:R:Y232	5.05	No	Yes	0	8	9
190	R:R:L234	R:R:R237	3.64	No	No	0	5	4
191	R:R:G236	R:R:V262	3.68	No	No	0	5	7
192	R:R:H258	R:R:L239	6.43	No	No	0	6	8
193	R:R:K259	R:R:W240	8.12	No	No	0	5	4
194	R:R:K259	R:R:K263	11.49	No	No	0	5	7
195	R:R:K263	R:R:Q260	5.42	No	No	0	7	7
196	R:R:M326	R:R:Q260	4.08	No	No	0	7	7
197	R:R:M264	R:R:M326	11.55	No	No	0	8	7
198	R:R:L322	R:R:V268	4.47	Yes	No	0	8	8
199	R:R:V268	R:R:Y323	3.79	No	Yes	0	8	9
200	R:R:F272	R:R:W276	16.04	No	Yes	1	9	8
201	R:R:C275	R:R:S315	6.89	No	No	0	9	9
202	R:R:F279	R:R:W276	4.01	No	Yes	1	6	8
203	R:R:H280	R:R:W276	3.17	No	Yes	1	7	8
204	R:R:F312	R:R:W276	4.01	No	Yes	1	7	8
205	R:R:S315	R:R:W276	3.71	No	Yes	0	9	8
206	R:R:L277	R:R:P278	3.28	No	No	0	6	9
207	R:R:L311	R:R:P278	3.28	No	No	0	7	9
208	R:R:F279	R:R:H280	5.66	No	No	1	6	7
209	R:R:F279	R:R:R283	12.83	No	Yes	1	6	6
210	R:R:G282	R:R:L285	3.42	Yes	No	0	4	4
211	R:R:C304	R:R:G282	3.92	No	Yes	0	5	4
212	L:L:?1	R:R:R283	13.87	Yes	Yes	1	0	6
213	R:R:L285	R:R:S301	4.5	No	No	0	4	4
214	R:R:F286	R:R:F290	6.43	Yes	Yes	2	4	1
215	R:R:E291	R:R:K288	6.75	No	No	0	1	4
216	R:R:I297	R:R:K288	8.72	No	No	0	1	4
217	R:R:F290	R:R:S289	3.96	Yes	No	2	1	2
218	R:R:I297	R:R:S289	3.1	No	No	0	1	2
219	R:R:I297	R:R:S294	6.19	No	No	0	1	6
220	R:R:E296	R:R:L295	6.63	No	No	0	2	7
221	R:R:A298	R:R:Q299	4.55	No	No	0	3	1
222	R:R:F309	R:R:Y313	9.28	No	Yes	0	5	7
223	R:R:I318	R:R:L314	7.14	No	No	0	7	5
224	R:R:I318	R:R:L322	4.28	No	Yes	0	7	8
225	R:R:N324	R:R:Y330	19.77	No	Yes	6	7	8
226	R:R:K328	R:R:R331	3.71	No	No	0	5	8
227	R:R:M65	R:R:S69	3.07	No	No	0	7	3
228	R:R:M65	R:R:S83	3.07	No	No	0	7	6
229	R:R:I167	R:R:V163	3.07	No	No	0	7	6
230	R:R:M213	R:R:S287	3.07	No	No	0	5	4
231	R:R:I273	R:R:V225	3.07	No	No	0	6	6
232	R:R:F121	R:R:G176	3.01	Yes	No	0	6	4
233	R:R:L306	R:R:V46	2.98	No	No	0	4	4
234	R:R:L63	R:R:V67	2.98	No	No	0	6	8
235	R:R:L63	R:R:V334	2.98	No	No	0	6	6
236	R:R:L80	R:R:V160	2.98	No	No	0	5	7
237	R:R:L118	R:R:V122	2.98	No	No	0	5	5
238	R:R:L231	R:R:V139	2.98	No	No	0	7	7
239	R:R:L162	R:R:V166	2.98	No	No	0	3	4
240	R:R:N305	R:R:S308	2.98	No	No	0	4	7
241	R:R:L311	R:R:V307	2.98	No	No	0	7	5
242	R:R:L53	R:R:T49	2.95	No	No	0	7	5
243	R:R:I321	R:R:I325	2.94	No	No	0	6	6
244	R:R:P108	R:R:R107	2.88	No	No	0	4	4
245	L:L:E9	L:L:V13	2.85	No	No	0	0	0
246	R:R:I58	R:R:L62	2.85	Yes	No	3	6	3
247	R:R:I58	R:R:L90	2.85	Yes	No	3	6	7
248	R:R:L322	R:R:M264	2.83	Yes	No	0	8	8
249	R:R:L103	R:R:L43	2.77	No	No	0	4	5
250	R:R:A317	R:R:F93	2.77	No	Yes	0	7	6
251	R:R:L274	R:R:L311	2.77	No	No	0	5	7
252	R:R:R70	R:R:S69	2.64	No	No	0	5	3
253	R:R:F143	R:R:V139	2.62	No	No	0	5	7
254	R:R:R150	R:R:V153	2.62	No	No	0	5	4
255	R:R:F226	R:R:V225	2.62	No	No	0	3	6
256	R:R:S327	R:R:Y330	2.54	No	Yes	0	8	8
257	R:R:F220	R:R:I219	2.51	Yes	No	0	6	5
258	R:R:V262	R:R:W240	2.45	No	No	0	7	4
259	L:L:F5	R:R:L103	2.44	Yes	No	2	0	4
260	R:R:F38	R:R:L103	2.44	Yes	No	2	4	4
261	R:R:F87	R:R:L91	2.44	No	No	0	6	7
262	R:R:F203	R:R:L209	2.44	No	Yes	0	6	4
263	R:R:I235	R:R:Y232	2.42	No	Yes	0	8	9
264	R:R:L210	R:R:W215	2.28	No	No	0	3	4
265	R:R:Q299	R:R:Y303	2.25	No	No	0	1	1
266	R:R:P39	R:R:P41	1.95	No	No	0	4	2
267	R:R:A44	R:R:G45	1.95	No	No	0	4	6
268	R:R:A59	R:R:G60	1.95	No	No	0	3	8
269	R:R:A40	R:R:P41	1.87	No	No	0	2	2
270	R:R:G57	R:R:V56	1.84	No	No	0	8	6
271	R:R:G282	R:R:V281	1.84	Yes	No	0	4	7
272	R:R:A129	R:R:A171	1.79	No	No	0	6	8
273	R:R:A144	R:R:A151	1.79	No	No	0	8	6
274	R:R:G158	R:R:K157	1.74	No	Yes	0	4	3
275	R:R:C95	R:R:S123	1.72	No	No	0	6	6
276	R:R:C126	R:R:V122	1.71	Yes	No	0	8	5
277	R:R:G282	R:R:N305	1.7	Yes	No	0	4	4
278	R:R:L35	R:R:P39	1.64	No	No	0	4	4
279	R:R:L149	R:R:P148	1.64	No	No	0	7	8
280	R:R:V310	R:R:V46	1.6	No	No	0	5	4
281	R:R:V153	R:R:V154	1.6	No	No	0	4	4
282	R:R:S233	R:R:T229	1.6	No	No	0	4	5
283	R:R:C126	R:R:L91	1.59	Yes	No	0	8	7
284	R:R:T229	R:R:V225	1.59	No	No	0	5	6
285	R:R:T229	R:R:V269	1.59	No	No	0	5	8
286	R:R:T261	R:R:V262	1.59	No	No	0	8	7
287	L:L:L6	R:R:A298	1.58	Yes	No	0	0	3
288	R:R:A271	R:R:L322	1.58	No	Yes	0	6	8
289	R:R:E291	R:R:P292	1.57	No	No	0	1	2
290	R:R:K329	R:R:S327	1.53	No	No	0	6	8
291	R:R:M264	R:R:V267	1.52	No	No	0	8	6
292	R:R:A333	R:R:E73	1.51	No	No	0	6	6
293	R:R:F111	R:R:G112	1.51	Yes	No	0	6	8
294	R:R:L80	R:R:S83	1.5	No	No	0	5	6
295	R:R:K157	R:R:T156	1.5	Yes	No	0	3	7
296	R:R:L132	R:R:V170	1.49	No	No	0	6	4
297	R:R:L181	R:R:V180	1.49	No	No	0	4	4
298	R:R:L234	R:R:V230	1.49	No	No	0	5	4
299	R:R:I325	R:R:M326	1.46	No	No	0	6	7
300	R:R:D191	R:R:T190	1.45	Yes	Yes	4	6	3
301	R:R:D194	R:R:T190	1.45	No	Yes	4	5	3
302	R:R:D194	R:R:T195	1.45	No	No	4	5	3
303	R:R:F38	R:R:P39	1.44	Yes	No	0	4	4
304	R:R:F147	R:R:P148	1.44	No	No	0	6	8
305	R:R:K157	R:R:K161	1.44	Yes	No	0	3	3
306	R:R:E296	R:R:S294	1.44	No	No	0	2	6
307	R:R:I300	R:R:L285	1.43	No	No	0	2	4
308	R:R:E185	R:R:T201	1.41	No	No	0	1	3
309	R:R:K259	R:R:N257	1.4	No	No	0	5	5
310	R:R:F54	R:R:V55	1.31	Yes	No	0	7	5
311	R:R:F111	R:R:V101	1.31	Yes	No	0	6	4
312	R:R:F165	R:R:V166	1.31	No	No	0	4	4
313	R:R:Q105	R:R:W104	1.1	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F5	4.07429	7	2	0
2	L:L:L6	6	6	2	0
3	R:R:F38	5.79	6	2	4
4	R:R:F54	5.8225	4	3	7
5	R:R:I58	6.135	4	3	6
6	R:R:N61	6.61	4	0	9
7	R:R:Y81	6.91	5	0	8
8	R:R:F93	4.6475	8	3	6
9	R:R:M96	7.405	4	0	7
10	R:R:W109	8.08	5	7	7
11	R:R:F111	5.676	5	0	6
12	R:R:D113	6.3	4	0	4
13	R:R:F119	6.356	5	0	4
14	R:R:Q120	6.435	4	0	4
15	R:R:F121	8.485	4	8	6
16	R:R:E124	10.435	4	1	4
17	R:R:C126	2.9125	4	0	8
18	R:R:Y128	10.8975	4	1	6
19	R:R:E140	6.9925	4	0	9
20	R:R:Y142	9.1225	4	0	8
21	R:R:K157	2.4075	4	0	3
22	R:R:W168	6.6125	4	0	9
23	R:R:T190	3.3125	4	4	3
24	R:R:D191	6.83	4	4	6
25	R:R:L209	3.9375	4	0	4
26	R:R:F220	7.195	4	1	6
27	R:R:Y232	6.29667	6	0	9
28	R:R:W276	5.98571	7	1	8
29	R:R:G282	2.72	4	0	4
30	R:R:R283	11.27	4	1	6
31	R:R:F286	6.55	4	2	4
32	R:R:F290	6.16167	6	2	1
33	R:R:Q302	5.5475	4	2	3
34	R:R:Y313	8.6225	4	0	7
35	R:R:L322	3.29	4	0	8
36	R:R:Y323	5.296	5	0	9
37	R:R:Y330	8.33	4	6	8
38	L:L:?1	10.3067	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F5	R:R:F309	50.0896	5.36	Yes	No	0	0	5
2	R:R:F309	R:R:Y313	50.6157	9.28	No	Yes	0	5	7
3	R:R:F93	R:R:Y313	99.5557	6.19	Yes	Yes	0	6	7
4	R:R:F93	R:R:I92	65.4404	3.77	Yes	No	0	6	7
5	R:R:C126	R:R:I92	30.5066	4.91	Yes	No	0	8	7
6	R:R:F312	R:R:I92	52.463	6.28	No	No	0	7	7
7	R:R:F312	R:R:W276	51.6329	4.01	No	Yes	1	7	8
8	R:R:F279	R:R:W276	51.3211	4.01	No	Yes	1	6	8
9	R:R:F279	R:R:R283	86.7888	12.83	No	Yes	1	6	6
10	L:L:?1	R:R:R283	22.5916	13.87	Yes	Yes	1	0	6
11	L:L:?1	L:L:S4	27.6461	12.86	Yes	No	0	0	0
12	L:L:F5	R:R:Q302	30.1715	3.51	Yes	Yes	2	0	3
13	L:L:L6	R:R:Q302	25.8574	5.32	Yes	Yes	2	0	3
14	L:L:L6	R:R:F286	14.3726	4.87	Yes	Yes	2	0	4
15	L:L:S4	R:R:F286	26.8083	10.57	No	Yes	0	0	4
16	L:L:F5	R:R:F38	18.7529	3.22	Yes	Yes	2	0	4
17	L:L:F5	R:R:R102	21.8862	6.41	Yes	No	0	0	5
18	L:L:F5	R:R:N305	12.5292	3.62	Yes	No	0	0	4
19	L:L:H10	L:L:L6	10.3274	11.57	No	Yes	2	0	0
20	L:L:L6	R:R:S289	13.8698	9.01	Yes	No	2	0	2
21	L:L:P8	R:R:L37	11.6329	13.14	No	No	0	0	5
22	L:L:H10	L:L:Q14	12.0966	9.89	No	No	0	0	0
23	L:L:F5	R:R:L103	11.7147	2.44	Yes	No	2	0	4
24	R:R:L103	R:R:L43	11.5355	2.77	No	No	0	4	5
25	R:R:F93	R:R:N61	97.7786	3.62	Yes	Yes	0	6	9
26	R:R:A86	R:R:N61	51.2627	4.69	No	Yes	0	9	9
27	R:R:A86	R:R:T64	50.226	3.36	No	No	0	9	9
28	R:R:N324	R:R:T64	41.6446	7.31	No	No	6	7	9
29	R:R:L82	R:R:N324	42.0109	5.49	No	No	0	8	7
30	R:R:L82	R:R:Y323	40.986	7.03	No	Yes	0	8	9
31	R:R:V268	R:R:Y323	83.297	3.79	No	Yes	0	8	9
32	R:R:L322	R:R:V268	79.4193	4.47	Yes	No	0	8	8
33	R:R:I318	R:R:L322	17.0031	4.28	No	Yes	0	7	8
34	R:R:I318	R:R:L314	12.7631	7.14	No	No	0	7	5
35	R:R:D89	R:R:N61	45.1637	6.73	No	Yes	0	9	9
36	R:R:D89	R:R:N319	87.5721	8.08	No	No	0	9	9
37	R:R:M85	R:R:N319	85.2728	5.61	No	No	0	9	9
38	R:R:I134	R:R:M85	80.8067	4.37	No	No	0	8	9
39	R:R:I134	R:R:Y323	78.6009	3.63	No	Yes	0	8	9
40	R:R:A316	R:R:F93	45.8418	5.55	No	Yes	0	9	6
41	R:R:A316	R:R:D89	44.809	4.63	No	No	0	9	9
42	R:R:E124	R:R:R283	32.5955	10.47	Yes	Yes	1	4	6
43	R:R:E124	R:R:Y128	72.9696	15.71	Yes	Yes	1	4	6
44	R:R:F220	R:R:Y128	100	11.35	Yes	Yes	1	6	6
45	R:R:F220	R:R:L132	95.5612	10.96	Yes	No	0	6	6
46	R:R:I167	R:R:L132	90.9314	9.99	No	No	0	7	6
47	R:R:I167	R:R:V163	88.6048	3.07	No	No	0	7	6
48	R:R:V163	R:R:Y81	86.2588	7.57	No	Yes	0	6	8
49	R:R:E140	R:R:Y81	44.5869	6.73	Yes	Yes	0	9	8
50	R:R:E140	R:R:T77	20.0117	9.88	Yes	No	0	9	7
51	R:R:T76	R:R:T77	35.0779	3.14	No	No	0	7	7
52	R:R:N79	R:R:T76	45.0546	5.85	No	No	0	8	7
53	R:R:R283	R:R:S217	32.915	7.91	Yes	No	0	6	6
54	R:R:S217	R:R:Y128	31.7693	7.63	No	Yes	0	6	6
55	R:R:V160	R:R:Y81	34.8558	12.62	No	Yes	0	7	8
56	R:R:T77	R:R:V160	20.1559	3.17	No	No	0	7	7
57	R:R:E140	R:R:T78	19.9922	4.23	Yes	No	0	9	8
58	R:R:T76	R:R:T78	17.5097	6.28	No	No	0	7	8
59	R:R:L74	R:R:N79	30.0663	4.12	No	No	0	8	8
60	R:R:A333	R:R:L74	15.0468	4.73	No	No	0	6	8
61	R:R:C126	R:R:S88	18.0982	3.44	Yes	No	0	8	8
62	R:R:S88	R:R:W168	15.1286	3.71	No	Yes	0	8	9
63	R:R:D99	R:R:Y313	50.1208	3.45	No	Yes	0	6	7
64	R:R:D99	R:R:F119	49.6687	4.78	No	Yes	0	6	4
65	R:R:F119	R:R:W109	28.4334	4.01	Yes	Yes	0	4	7
66	R:R:F119	R:R:Q120	47.0694	3.51	Yes	Yes	0	4	4
67	R:R:V184	R:R:W109	18.6165	3.68	No	Yes	0	5	7
68	R:R:V131	R:R:W276	10.0974	3.68	No	Yes	1	8	8
69	R:R:R141	R:R:Y323	50.1052	6.17	No	Yes	0	9	9
70	R:R:R141	R:R:Y232	49.0647	4.12	No	Yes	0	9	9
71	R:R:I235	R:R:Y232	46.0522	2.42	No	Yes	0	8	9
72	R:R:I235	R:R:Y142	36.59	3.63	No	Yes	0	8	8
73	R:R:C146	R:R:Y142	12.3889	9.41	No	Yes	0	7	8
74	R:R:L231	R:R:Y142	14.8441	15.24	No	Yes	0	7	8
75	R:R:L231	R:R:V139	12.3889	2.98	No	No	0	7	7
76	L:L:?1	R:R:M213	22.7202	5.38	Yes	No	0	0	5
77	R:R:L181	R:R:M213	13.636	4.24	No	No	0	4	5
78	R:R:L181	R:R:L209	10.9704	4.15	No	Yes	0	4	4
79	R:R:N196	R:R:V184	16.1302	5.91	No	No	0	4	5
80	R:R:N196	R:R:P192	14.5518	3.26	No	No	0	4	1
81	R:R:D191	R:R:P192	11.3718	8.05	Yes	No	0	6	1
82	R:R:F221	R:R:H280	39.357	16.97	No	No	0	8	7
83	R:R:F221	R:R:F222	33.6516	4.29	No	No	0	8	4
84	R:R:F222	R:R:F226	31.7966	5.36	No	No	0	4	3
85	R:R:F226	R:R:V225	30.9002	2.62	No	No	0	3	6
86	R:R:T229	R:R:V225	29.1231	1.59	No	No	0	5	6
87	R:R:T229	R:R:V269	27.3733	1.59	No	No	0	5	8
88	R:R:L322	R:R:M264	54.5518	2.83	Yes	No	0	8	8
89	R:R:M264	R:R:M326	46.2081	11.55	No	No	0	8	7
90	R:R:M326	R:R:Q260	33.6321	4.08	No	No	0	7	7
91	R:R:K263	R:R:Q260	29.4271	5.42	No	No	0	7	7
92	R:R:K259	R:R:K263	25.2104	11.49	No	No	0	5	7
93	R:R:K259	R:R:W240	16.7537	8.12	No	No	0	5	4
94	R:R:V262	R:R:W240	12.7631	2.45	No	No	0	7	4
95	R:R:I297	R:R:S289	16.8277	3.1	No	No	0	1	2
96	R:R:L80	R:R:V160	12.7319	2.98	No	No	0	5	7
97	R:R:L80	R:R:S83	10.2065	1.5	No	No	0	5	6
98	R:R:Q120	R:R:R102	21.59	3.5	Yes	No	0	4	5
99	L:L:?1	R:R:Q120	59.244	10.13	Yes	Yes	0	0	4
100	L:L:?1	R:R:E124	41.9953	10.09	Yes	Yes	1	0	4
101	R:R:F279	R:R:H280	35.3741	5.66	No	No	1	6	7
102	R:R:V269	R:R:Y232	27.0772	5.05	No	Yes	0	8	9
103	R:R:F286	R:R:F290	12.5604	6.43	Yes	Yes	2	4	1

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G2	R:R:S123	3.71	0	No	No	0	6	0	1
L:L:S4	R:R:F286	10.57	0	No	Yes	0	4	0	1
L:L:F5	R:R:F38	3.22	2	Yes	Yes	0	4	0	1
L:L:F5	R:R:R102	6.41	2	Yes	No	0	5	0	1
L:L:F5	R:R:Q302	3.51	2	Yes	Yes	0	3	0	1
L:L:F5	R:R:N305	3.62	2	Yes	No	0	4	0	1
L:L:F5	R:R:F309	5.36	2	Yes	No	0	5	0	1
L:L:L6	R:R:F286	4.87	2	Yes	Yes	0	4	0	1
L:L:L6	R:R:S289	9.01	2	Yes	No	0	2	0	1
L:L:L6	R:R:F290	3.65	2	Yes	Yes	0	1	0	1
L:L:L6	R:R:Q302	5.32	2	Yes	Yes	0	3	0	1
L:L:S7	R:R:Y106	8.9	5	No	No	0	3	0	1
L:L:S7	R:R:E197	4.31	5	No	No	0	4	0	1
L:L:P8	R:R:Q36	6.32	0	No	No	0	5	0	1
L:L:P8	R:R:L37	13.14	0	No	No	0	5	0	1
L:L:P8	R:R:Y106	9.74	0	No	No	0	3	0	1
L:L:H10	R:R:F290	7.92	2	No	Yes	0	1	0	1
L:L:Q11	R:R:Q299	3.84	0	No	No	0	1	0	1
R:R:F38	R:R:L37	4.87	2	Yes	No	4	5	1	1
R:R:L37	R:R:Q302	3.99	2	No	Yes	5	3	1	1
R:R:F38	R:R:Q302	9.37	2	Yes	Yes	4	3	1	1
R:R:F38	R:R:L306	13.4	2	Yes	No	4	4	1	2
R:R:Q120	R:R:R102	3.5	0	Yes	No	4	5	1	1
R:R:E197	R:R:Y106	15.71	5	No	No	4	3	1	1
R:R:F119	R:R:Q120	3.51	0	Yes	Yes	4	4	2	1
R:R:Q120	R:R:V182	8.6	0	Yes	No	4	4	1	2
L:L:?1	R:R:Q120	10.13	1	Yes	Yes	0	4	0	1
R:R:E124	R:R:Y128	15.71	1	Yes	Yes	4	6	1	2
R:R:E124	R:R:I178	5.47	1	Yes	No	4	4	1	1
R:R:E124	R:R:R283	10.47	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:E124	10.09	1	Yes	Yes	0	4	0	1
R:R:S217	R:R:Y128	7.63	0	No	Yes	6	6	2	2
L:L:?1	R:R:I178	9.51	1	Yes	No	0	4	0	1
R:R:L181	R:R:M213	4.24	0	No	No	4	5	2	1
R:R:E197	R:R:R199	5.82	5	No	No	4	3	1	2
R:R:F290	R:R:R199	3.21	2	Yes	No	1	3	1	2
R:R:F286	R:R:P200	4.33	2	Yes	No	4	4	1	2
R:R:F290	R:R:V205	11.8	2	Yes	No	1	4	1	2
L:L:?1	R:R:M213	5.38	1	Yes	No	0	5	0	1
R:R:R283	R:R:S217	7.91	1	Yes	No	6	6	1	2
R:R:F279	R:R:R283	12.83	1	No	Yes	6	6	2	1
L:L:?1	R:R:R283	13.87	1	Yes	Yes	0	6	0	1
R:R:F286	R:R:F290	6.43	2	Yes	Yes	4	1	1	1
R:R:F290	R:R:S289	3.96	2	Yes	No	1	2	1	1
R:R:I297	R:R:S289	3.1	0	No	No	1	2	2	1
R:R:A298	R:R:Q299	4.55	0	No	No	3	1	1	1
R:R:F309	R:R:Y313	9.28	0	No	Yes	5	7	1	2
R:R:M213	R:R:S287	3.07	0	No	No	5	4	1	2
R:R:N305	R:R:S308	2.98	0	No	No	4	7	1	2
R:R:L103	R:R:L43	2.77	2	No	No	4	5	1	2
L:L:F5	R:R:L103	2.44	2	Yes	No	0	4	0	1
R:R:F38	R:R:L103	2.44	2	Yes	No	4	4	1	1
R:R:Q299	R:R:Y303	2.25	0	No	No	1	1	1	2
R:R:C95	R:R:S123	1.72	0	No	No	6	6	2	1
R:R:G282	R:R:N305	1.7	0	Yes	No	4	4	2	1
L:L:L6	R:R:A298	1.58	2	Yes	No	0	3	0	1
R:R:F38	R:R:P39	1.44	2	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F9Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	282
Number of Links	313
Number of Hubs	38
Number of Links mediated by Hubs	152
Number of Communities	8
Number of Nodes involved in Communities	46
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	104
Number Of Links MetaPath	103
Number of Shortest Paths	77857
Length Of Smallest Path	3
Average Path Length	16.2821
Length of Longest Path	36
Minimum Path Strength	1.41
Average Path Strength	6.23242
Maximum Path Strength	16.81
Minimum Path Correlation	0.7
Average Path Correlation	0.927678
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	45.0364
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9762
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	OCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OCA
Name	Caprylic acid
Synonyms	n-octylic acid
Identifier
Formula	C8 H16 O2
Molecular Weight	144.211
SMILES
PubChem	379
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	0
Total Bonds	25
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92847
Sequence	>7F9Y_nogp_Chain_R L Q L F P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F R E L R T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y R P W N F G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F P L R A K V V V T K G R V K L V I F V I W A V A F C S A G P I F V L V G V E H E N G T D P W D T N E C R P T E F A V R S G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E P G S L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K Y R V A V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JSR	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	8JSR (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	7F83	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PF-05190457	-	-	2.94	2022-01-19	10.1038/s41467-022-27975-9
	7W2Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-	Go/β1/γ2	2.8	2022-01-19	10.1038/s41467-022-27975-9
	7W2Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-		2.8	2022-01-19	10.1038/s41467-022-27975-9
	7NA8	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-	Gi1/β1/γ2	2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA8 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-		2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA7	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-	Gi1/β1/γ2	2.7	2021-12-15	10.1038/s41467-021-26735-5
	7NA7 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-		2.7	2021-12-15	10.1038/s41467-021-26735-5
	7F9Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-08-18	10.1038/s41467-021-25364-2
	7F9Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-		3.2	2021-08-18	10.1038/s41467-021-25364-2
	7F9Y	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-08-18	10.1038/s41467-021-25364-2
	7F9Y (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-		2.9	2021-08-18	10.1038/s41467-021-25364-2
	6KO5	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 57400002	-	-	3.3	2020-08-12	10.1038/s41467-020-17554-1

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