psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L103	R:R:L43	4.15	No	No	0	4	5
2	R:R:L43	R:R:W104	22.78	No	No	0	5	4
3	R:R:L100	R:R:T47	8.84	No	No	0	7	6
4	R:R:T47	R:R:W104	3.64	No	No	0	6	4
5	R:R:L314	R:R:L53	4.15	No	No	0	5	7
6	R:R:F54	R:R:I58	8.79	No	Yes	4	7	6
7	R:R:F54	R:R:F93	6.43	No	Yes	4	7	6
8	R:R:F54	R:R:M96	7.46	No	Yes	0	7	7
9	R:R:F93	R:R:G57	4.52	Yes	No	0	6	8
10	R:R:F93	R:R:I58	5.02	Yes	Yes	4	6	6
11	R:R:G60	R:R:P320	4.06	No	No	0	8	9
12	R:R:A86	R:R:N61	4.69	No	No	0	9	9
13	R:R:D89	R:R:N61	10.77	Yes	No	0	9	9
14	R:R:N61	R:R:P320	6.52	No	No	0	9	9
15	R:R:T64	R:R:Y330	4.99	No	Yes	0	9	8
16	R:R:F71	R:R:V67	3.93	Yes	No	0	5	8
17	R:R:F71	R:R:R70	8.55	Yes	No	5	5	5
18	R:R:L337	R:R:R70	6.07	No	No	5	5	5
19	R:R:A333	R:R:F71	8.32	No	Yes	0	6	5
20	R:R:F71	R:R:R336	4.28	Yes	No	0	5	3
21	R:R:F71	R:R:L337	3.65	Yes	No	5	5	5
22	R:R:R72	R:R:R75	4.26	No	No	0	6	7
23	R:R:E73	R:R:L74	5.3	No	No	0	6	8
24	R:R:K329	R:R:L74	5.64	No	No	0	6	8
25	R:R:N79	R:R:T76	10.24	No	No	0	8	7
26	R:R:T77	R:R:Y81	3.75	No	Yes	2	7	8
27	R:R:E140	R:R:T77	11.29	No	No	2	9	7
28	R:R:T77	R:R:V160	7.93	No	No	2	7	7
29	R:R:K157	R:R:L80	4.23	No	No	0	3	5
30	R:R:A136	R:R:Y81	5.34	No	Yes	0	7	8
31	R:R:L137	R:R:Y81	3.52	Yes	Yes	2	8	8
32	R:R:E140	R:R:Y81	4.49	No	Yes	2	9	8
33	R:R:V160	R:R:Y81	5.05	No	Yes	2	7	8
34	R:R:V163	R:R:Y81	7.57	No	Yes	0	6	8
35	R:R:I164	R:R:Y81	4.84	No	Yes	0	7	8
36	R:R:L137	R:R:L82	6.92	Yes	No	2	8	8
37	R:R:L82	R:R:Y323	5.86	No	Yes	2	8	9
38	R:R:L82	R:R:N324	4.12	No	No	0	8	7
39	R:R:I164	R:R:S84	9.29	No	No	0	7	9
40	R:R:D89	R:R:M85	4.16	Yes	Yes	0	9	9
41	R:R:I134	R:R:M85	4.37	Yes	Yes	0	8	9
42	R:R:M85	R:R:N319	5.61	Yes	No	0	9	9
43	R:R:F87	R:R:L91	10.96	No	Yes	0	6	7
44	R:R:F87	R:R:W168	5.01	No	Yes	0	6	9
45	R:R:S88	R:R:W168	7.41	No	Yes	0	8	9
46	R:R:D89	R:R:K130	12.44	Yes	No	0	9	9
47	R:R:A316	R:R:D89	6.18	No	Yes	0	9	9
48	R:R:C126	R:R:L91	4.76	No	Yes	0	8	7
49	R:R:F312	R:R:I92	6.28	Yes	No	0	7	7
50	R:R:A316	R:R:F93	5.55	No	Yes	0	9	6
51	R:R:C95	R:R:V122	3.42	No	No	0	6	5
52	R:R:M96	R:R:Y313	16.76	Yes	Yes	0	7	7
53	R:R:L115	R:R:L98	5.54	No	No	0	5	5
54	R:R:F119	R:R:L98	15.83	Yes	No	0	4	5
55	R:R:D99	R:R:R102	4.76	Yes	Yes	1	6	5
56	R:R:D99	R:R:F119	8.36	Yes	Yes	1	6	4
57	R:R:D99	R:R:F309	3.58	Yes	Yes	1	6	5
58	R:R:D99	R:R:Y313	5.75	Yes	Yes	1	6	7
59	R:R:Q105	R:R:V101	5.73	No	No	0	4	4
60	R:R:F111	R:R:V101	6.55	No	No	0	6	4
61	R:R:R102	R:R:Y106	11.32	Yes	No	0	5	3
62	R:R:R102	R:R:W109	6	Yes	Yes	1	5	7
63	R:R:F119	R:R:R102	8.55	Yes	Yes	1	4	5
64	R:R:Q120	R:R:R102	8.18	Yes	Yes	1	4	5
65	R:R:F309	R:R:L103	4.87	Yes	No	1	5	4
66	L:L:F4	R:R:L103	10.96	Yes	No	1	0	4
67	R:R:P108	R:R:Q105	11.05	No	No	0	4	4
68	R:R:Q105	R:R:W109	4.38	No	Yes	0	4	7
69	R:R:E197	R:R:Y106	4.49	Yes	No	0	4	3
70	R:R:E197	R:R:R107	5.82	Yes	No	0	4	4
71	L:L:E8	R:R:R107	13.96	No	No	0	0	4
72	R:R:F111	R:R:W109	15.03	No	Yes	0	6	7
73	R:R:F119	R:R:W109	8.02	Yes	Yes	1	4	7
74	R:R:C198	R:R:W109	14.37	No	Yes	1	9	7
75	R:R:D113	R:R:K117	8.3	No	No	6	4	7
76	R:R:D113	R:R:G183	5.03	No	No	6	4	4
77	R:R:D113	R:R:V184	8.76	No	No	0	4	5
78	R:R:C116	R:R:V182	3.42	No	No	0	9	4
79	R:R:C116	R:R:V184	3.42	No	No	0	9	5
80	R:R:C116	R:R:C198	7.28	No	No	0	9	9
81	R:R:F179	R:R:K117	4.96	No	No	0	5	7
82	R:R:G183	R:R:K117	3.49	No	No	6	4	7
83	R:R:F119	R:R:Q120	14.05	Yes	Yes	1	4	4
84	R:R:C198	R:R:F119	4.19	No	Yes	1	9	4
85	R:R:I178	R:R:Q120	4.12	No	Yes	1	4	4
86	R:R:Q120	R:R:V182	12.89	Yes	No	1	4	4
87	R:R:F121	R:R:F172	5.36	Yes	No	0	6	4
88	R:R:F121	R:R:I178	3.77	Yes	No	0	6	4
89	R:R:F121	R:R:F179	16.08	Yes	No	0	6	5
90	R:R:E124	R:R:Y128	7.86	No	Yes	1	4	6
91	R:R:E124	R:R:R283	11.63	No	No	1	4	6
92	L:L:?3	R:R:E124	7.11	Yes	No	1	0	4
93	R:R:F172	R:R:S125	5.28	No	No	0	4	5
94	R:R:F312	R:R:T127	9.08	Yes	No	0	7	7
95	R:R:S217	R:R:Y128	8.9	No	Yes	0	6	6
96	R:R:F220	R:R:Y128	28.88	No	Yes	0	6	6
97	L:L:?3	R:R:Y128	4.49	Yes	Yes	1	0	6
98	R:R:A129	R:R:W168	7.78	No	Yes	0	6	9
99	R:R:K130	R:R:W276	3.48	No	Yes	0	9	8
100	R:R:K130	R:R:N319	6.99	No	No	0	9	9
101	R:R:F272	R:R:V131	5.24	Yes	No	7	9	8
102	R:R:V131	R:R:W276	6.13	No	Yes	7	8	8
103	R:R:I167	R:R:L132	7.14	No	No	0	7	6
104	R:R:I134	R:R:L228	4.28	Yes	No	0	8	8
105	R:R:F272	R:R:I134	6.28	Yes	Yes	0	9	8
106	R:R:I134	R:R:Y323	4.84	Yes	Yes	0	8	9
107	R:R:P224	R:R:T135	5.25	No	No	0	9	7
108	R:R:C227	R:R:T135	3.38	No	No	0	6	7
109	R:R:L137	R:R:Y323	5.86	Yes	Yes	2	8	9
110	R:R:L228	R:R:S138	6.01	No	No	8	8	9
111	R:R:S138	R:R:Y232	3.82	No	Yes	8	9	9
112	R:R:F143	R:R:V139	5.24	No	No	0	5	7
113	R:R:E140	R:R:V155	11.41	No	No	0	9	7
114	R:R:R141	R:R:Y232	9.26	No	Yes	0	9	9
115	R:R:R141	R:R:Y323	7.2	No	Yes	0	9	9
116	R:R:F143	R:R:Y142	6.19	No	Yes	0	5	8
117	R:R:C146	R:R:Y142	9.41	No	Yes	0	7	8
118	R:R:F147	R:R:Y142	5.16	No	Yes	0	6	8
119	R:R:L231	R:R:Y142	16.41	No	Yes	0	7	8
120	R:R:L234	R:R:Y142	8.21	No	Yes	0	5	8
121	R:R:I235	R:R:Y142	3.63	No	Yes	0	8	8
122	R:R:F147	R:R:R150	5.34	No	No	0	6	5
123	R:R:R159	R:R:T156	3.88	No	No	0	5	7
124	R:R:F172	R:R:W168	5.01	No	Yes	0	4	9
125	R:R:F220	R:R:S174	7.93	No	No	0	6	5
126	R:R:G176	R:R:P177	4.06	No	No	0	4	7
127	R:R:M213	R:R:P177	8.39	No	No	0	5	7
128	R:R:I178	R:R:V182	6.14	No	No	1	4	4
129	R:R:L181	R:R:P200	4.93	No	No	0	4	4
130	R:R:L181	R:R:L209	4.15	No	No	0	4	4
131	R:R:N196	R:R:V184	5.91	No	No	0	4	5
132	R:R:E185	R:R:R199	5.82	No	No	9	1	3
133	R:R:E185	R:R:T201	4.23	No	No	0	1	3
134	R:R:E185	R:R:E202	6.34	No	No	9	1	6
135	R:R:H186	R:R:N196	3.83	No	No	0	2	4
136	L:L:E8	R:R:E187	3.81	No	No	0	0	3
137	R:R:D194	R:R:T190	5.78	No	No	0	5	3
138	R:R:D191	R:R:W193	13.4	No	Yes	10	6	4
139	R:R:D191	R:R:D194	5.32	No	No	10	6	5
140	R:R:D194	R:R:W193	8.93	No	Yes	10	5	4
141	R:R:E197	R:R:T195	5.64	Yes	No	0	4	3
142	R:R:E197	R:R:R199	5.82	Yes	No	0	4	3
143	L:L:S6	R:R:E197	4.31	No	Yes	0	0	4
144	R:R:E202	R:R:R199	9.3	No	No	9	6	3
145	R:R:F286	R:R:P200	4.33	Yes	No	0	4	4
146	R:R:F203	R:R:S207	9.25	No	No	0	6	3
147	R:R:F290	R:R:V205	15.73	Yes	No	0	1	4
148	R:R:F286	R:R:L210	4.87	Yes	No	0	4	3
149	R:R:L210	R:R:S287	4.5	No	No	0	3	4
150	R:R:T211	R:R:W215	4.85	Yes	No	0	4	4
151	R:R:S287	R:R:T211	4.8	No	Yes	0	4	4
152	L:L:?3	R:R:M213	4.33	Yes	No	0	0	5
153	R:R:S287	R:R:V214	8.08	No	No	0	4	5
154	R:R:F222	R:R:S218	3.96	No	No	0	4	4
155	R:R:F221	R:R:F222	4.29	No	No	0	8	4
156	R:R:F221	R:R:L277	7.31	No	No	0	8	6
157	R:R:F221	R:R:H280	13.58	No	No	0	8	7
158	R:R:L223	R:R:P224	6.57	No	No	0	5	9
159	R:R:F272	R:R:P224	5.78	Yes	No	0	9	9
160	R:R:F226	R:R:V225	3.93	No	No	0	3	6
161	R:R:L228	R:R:Y232	3.52	No	Yes	8	8	9
162	R:R:L265	R:R:Y232	12.89	No	Yes	0	8	9
163	R:R:V268	R:R:Y232	5.05	No	Yes	0	8	9
164	R:R:V269	R:R:Y232	5.05	No	Yes	0	8	9
165	R:R:L234	R:R:R237	3.64	No	No	0	5	4
166	R:R:R237	R:R:R241	15.99	No	No	0	4	5
167	R:R:K238	R:R:R242	4.95	No	No	0	5	5
168	R:R:H258	R:R:L239	16.71	Yes	No	0	6	8
169	R:R:K259	R:R:W240	3.48	No	No	0	5	4
170	R:R:R242	R:R:R243	4.26	No	No	0	5	3
171	R:R:D255	R:R:R243	3.57	No	No	11	1	3
172	R:R:H258	R:R:R243	11.28	Yes	No	11	6	3
173	R:R:D255	R:R:N257	8.08	No	No	0	1	5
174	R:R:D255	R:R:H258	3.78	No	Yes	11	1	6
175	R:R:N257	R:R:Q256	3.96	No	No	0	5	4
176	R:R:Q256	R:R:Q260	6.4	No	No	0	4	7
177	R:R:K263	R:R:Q260	5.42	No	No	0	7	7
178	R:R:M264	R:R:M326	4.33	No	No	0	8	7
179	R:R:V268	R:R:Y323	3.79	No	Yes	0	8	9
180	R:R:F272	R:R:W276	19.04	Yes	Yes	7	9	8
181	R:R:C275	R:R:S315	6.89	No	No	0	9	9
182	R:R:F279	R:R:W276	5.01	Yes	Yes	0	6	8
183	R:R:F312	R:R:W276	4.01	Yes	Yes	0	7	8
184	R:R:L311	R:R:P278	4.93	No	No	0	7	9
185	R:R:F279	R:R:H280	4.53	Yes	No	0	6	7
186	R:R:F279	R:R:R283	13.9	Yes	No	0	6	6
187	L:L:S2	R:R:F279	5.28	No	Yes	0	0	6
188	R:R:C304	R:R:G282	3.92	No	No	0	5	4
189	R:R:G282	R:R:N305	5.09	No	No	0	4	4
190	L:L:?3	R:R:R283	13.97	Yes	No	1	0	6
191	R:R:L285	R:R:Y284	3.52	Yes	No	0	4	5
192	R:R:K288	R:R:Y284	8.36	No	No	0	4	5
193	R:R:F286	R:R:F290	10.72	Yes	Yes	0	4	1
194	L:L:?3	R:R:F286	9.33	Yes	Yes	0	0	4
195	L:L:L5	R:R:F286	4.87	Yes	Yes	0	0	4
196	R:R:F290	R:R:S289	5.28	Yes	No	3	1	2
197	L:L:L5	R:R:S289	7.51	Yes	No	3	0	2
198	L:L:H9	R:R:S289	4.18	Yes	No	3	0	2
199	L:L:H9	R:R:F290	6.79	Yes	Yes	3	0	1
200	R:R:E291	R:R:P292	4.72	No	No	0	1	2
201	L:L:R11	R:R:P292	4.32	No	No	0	0	2
202	R:R:E296	R:R:I300	10.93	No	No	0	2	2
203	R:R:Q299	R:R:Y303	12.4	No	No	0	1	1
204	R:R:N305	R:R:S301	5.96	No	No	0	4	4
205	R:R:Q302	R:R:Y303	3.38	No	No	0	3	1
206	L:L:?3	R:R:N305	12.63	Yes	No	0	0	4
207	R:R:F309	R:R:Y313	13.41	Yes	Yes	1	5	7
208	L:L:S2	R:R:F309	6.61	No	Yes	0	0	5
209	L:L:F4	R:R:F309	5.36	Yes	Yes	1	0	5
210	R:R:F312	R:R:Y313	11.35	Yes	Yes	0	7	7
211	R:R:I318	R:R:L314	4.28	No	No	0	7	5
212	R:R:I318	R:R:L322	4.28	No	No	0	7	8
213	R:R:I321	R:R:I325	4.42	No	No	0	6	6
214	R:R:N324	R:R:Y330	22.1	No	Yes	0	7	8
215	R:R:I325	R:R:M326	5.83	No	No	0	6	7
216	R:R:K328	R:R:R331	8.66	No	No	0	5	8
217	R:R:V334	R:R:Y330	8.83	No	Yes	0	6	8
218	R:R:F335	R:R:V334	3.93	No	No	0	3	6
219	L:L:?3	L:L:F4	9.33	Yes	Yes	1	0	0
220	L:L:H9	L:L:L5	5.14	Yes	Yes	3	0	0
221	L:L:P7	L:L:S6	3.56	No	No	0	0	0
222	L:L:E8	L:L:Q10	6.37	No	No	0	0	0
223	L:L:H9	L:L:R11	9.03	Yes	No	0	0	0
224	R:R:M96	R:R:P97	3.35	Yes	No	0	7	7
225	R:R:L277	R:R:P278	3.28	No	No	0	6	9
226	R:R:C50	R:R:M96	3.24	No	Yes	0	6	7
227	R:R:C146	R:R:K238	3.23	No	No	0	7	5
228	R:R:F335	R:R:F340	3.22	No	No	0	3	4
229	R:R:V334	R:R:V67	3.21	No	No	0	6	8
230	R:R:T49	R:R:V46	3.17	No	Yes	0	5	4
231	R:R:C227	R:R:L231	3.17	No	No	0	6	7
232	R:R:C304	R:R:L285	3.17	No	Yes	0	5	4
233	R:R:A317	R:R:L53	3.15	No	No	0	7	7
234	R:R:A204	R:R:L181	3.15	No	No	0	4	4
235	R:R:T190	R:R:T195	3.14	No	No	0	3	3
236	R:R:I297	R:R:S294	3.1	No	No	0	1	6
237	R:R:I167	R:R:V163	3.07	No	No	0	7	6
238	R:R:I273	R:R:V225	3.07	No	No	0	6	6
239	R:R:I273	R:R:V269	3.07	No	No	0	6	8
240	R:R:M85	R:R:T133	3.01	Yes	No	0	9	8
241	L:L:G1	R:R:F279	3.01	No	Yes	0	0	6
242	R:R:L80	R:R:S83	3	No	No	0	5	6
243	R:R:L80	R:R:V160	2.98	No	No	0	5	7
244	R:R:L91	R:R:V122	2.98	Yes	No	0	7	5
245	R:R:L118	R:R:V122	2.98	No	No	0	5	5
246	R:R:L132	R:R:V170	2.98	No	No	0	6	4
247	R:R:L231	R:R:V230	2.98	No	No	0	7	4
248	R:R:L322	R:R:V268	2.98	No	No	0	8	8
249	R:R:L277	R:R:V281	2.98	No	No	0	6	7
250	R:R:L285	R:R:V281	2.98	Yes	No	0	4	7
251	R:R:N79	R:R:V68	2.96	No	No	0	8	7
252	R:R:L137	R:R:T78	2.95	Yes	No	0	8	8
253	R:R:L239	R:R:T261	2.95	No	No	0	8	8
254	R:R:I145	R:R:I235	2.94	No	No	0	9	8
255	R:R:K263	R:R:M264	2.88	No	No	0	7	8
256	R:R:K157	R:R:K161	2.87	No	No	0	3	3
257	L:L:Q10	L:L:V12	2.87	No	No	0	0	0
258	R:R:I58	R:R:L62	2.85	Yes	No	0	6	3
259	R:R:I58	R:R:L90	2.85	Yes	No	0	6	7
260	R:R:I219	R:R:L223	2.85	No	No	0	5	5
261	R:R:I297	R:R:L285	2.85	No	Yes	0	1	4
262	R:R:L62	R:R:M65	2.83	No	No	0	3	7
263	R:R:L90	R:R:M65	2.83	No	No	0	7	7
264	R:R:L337	R:R:L66	2.77	No	No	0	5	3
265	R:R:A175	R:R:F121	2.77	No	Yes	0	7	6
266	R:R:L274	R:R:L311	2.77	No	No	0	5	7
267	R:R:L74	R:R:N79	2.75	No	No	0	8	8
268	R:R:E296	R:R:I297	2.73	No	No	0	2	1
269	R:R:P192	R:R:W193	2.7	No	Yes	0	1	4
270	L:L:L5	R:R:Q302	2.66	Yes	No	0	0	3
271	R:R:F312	R:R:S123	2.64	Yes	No	0	7	6
272	R:R:C275	R:R:W276	2.61	No	Yes	0	9	8
273	R:R:E187	R:R:Q188	2.55	No	No	0	3	3
274	R:R:S327	R:R:Y330	2.54	No	Yes	0	8	8
275	R:R:F165	R:R:K161	2.48	No	No	0	4	3
276	R:R:F203	R:R:L209	2.44	No	No	0	6	4
277	L:L:F4	R:R:L306	2.44	Yes	No	0	0	4
278	R:R:E73	R:R:F71	2.33	No	Yes	0	6	5
279	R:R:G293	R:R:P292	2.03	No	No	0	2	2
280	R:R:A44	R:R:G45	1.95	No	No	0	4	6
281	R:R:A59	R:R:G60	1.95	No	No	0	3	8
282	R:R:A40	R:R:P41	1.87	No	No	0	2	2
283	R:R:G236	R:R:V262	1.84	No	No	0	5	7
284	R:R:G158	R:R:T156	1.82	No	No	0	4	7
285	R:R:G208	R:R:T211	1.82	No	Yes	0	2	4
286	R:R:A129	R:R:A171	1.79	No	No	0	6	8
287	R:R:P278	R:R:S308	1.78	No	No	0	9	7
288	R:R:P177	R:R:V180	1.77	No	No	0	7	4
289	R:R:G236	R:R:I235	1.76	No	No	0	5	8
290	R:R:C50	R:R:V46	1.71	No	Yes	0	6	4
291	R:R:G60	R:R:L63	1.71	No	No	0	8	6
292	R:R:G112	R:R:L115	1.71	No	No	0	8	5
293	R:R:C304	R:R:V307	1.71	No	No	0	5	5
294	R:R:G339	R:R:L338	1.71	No	No	0	5	7
295	R:R:A317	R:R:V56	1.7	No	No	0	7	6
296	R:R:A151	R:R:V155	1.7	No	No	0	6	7
297	R:R:L149	R:R:P148	1.64	No	No	0	7	8
298	R:R:G189	R:R:Q188	1.64	No	No	0	4	3
299	R:R:V310	R:R:V46	1.6	No	Yes	0	5	4
300	R:R:V166	R:R:V170	1.6	No	No	0	4	4
301	R:R:V212	R:R:V216	1.6	No	No	0	6	5
302	R:R:T211	R:R:V212	1.59	Yes	No	0	4	6
303	R:R:T229	R:R:V225	1.59	No	No	0	5	6
304	R:R:T229	R:R:V269	1.59	No	No	0	5	8
305	R:R:A271	R:R:L322	1.58	No	No	0	6	8
306	R:R:K263	R:R:V267	1.52	No	No	0	7	6
307	R:R:L42	R:R:V46	1.49	No	Yes	0	3	4
308	R:R:F147	R:R:P148	1.44	No	No	0	6	8
309	R:R:A266	R:R:F270	1.39	No	No	0	5	5
310	R:R:L91	R:R:L94	1.38	Yes	No	0	7	5
311	R:R:R75	R:R:V68	1.31	No	No	0	7	7
312	R:R:R150	R:R:V154	1.31	No	No	0	5	4
313	R:R:R159	R:R:V154	1.31	No	No	0	5	4
314	R:R:H258	R:R:K259	1.31	Yes	No	0	6	5
315	R:R:N110	R:R:W193	1.13	No	Yes	0	3	4
316	R:R:F335	R:R:R331	1.07	No	No	0	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V46	1.9925	4	0	4
2	R:R:I58	4.8775	4	4	6
3	R:R:F71	5.17667	6	5	5
4	R:R:Y81	4.93714	7	2	8
5	R:R:M85	4.2875	4	0	9
6	R:R:D89	8.3875	4	0	9
7	R:R:L91	5.02	4	0	7
8	R:R:F93	5.38	4	4	6
9	R:R:M96	7.7025	4	0	7
10	R:R:D99	5.6125	4	1	6
11	R:R:R102	7.762	5	1	5
12	R:R:W109	9.56	5	1	7
13	R:R:F119	9.83333	6	1	4
14	R:R:Q120	9.81	4	1	4
15	R:R:F121	6.995	4	0	6
16	R:R:Y128	12.5325	4	1	6
17	R:R:I134	4.9425	4	0	8
18	R:R:L137	4.8125	4	2	8
19	R:R:Y142	8.16833	6	0	8
20	R:R:W168	6.3025	4	0	9
21	R:R:W193	6.54	4	10	4
22	R:R:E197	5.216	5	0	4
23	R:R:T211	3.265	4	0	4
24	R:R:Y232	6.59833	6	8	9
25	R:R:H258	8.27	4	11	6
26	R:R:F272	9.085	4	7	9
27	R:R:W276	6.71333	6	7	8
28	R:R:F279	6.346	5	0	6
29	R:R:L285	3.13	4	0	4
30	R:R:F286	6.824	5	0	4
31	R:R:F290	9.63	4	3	1
32	R:R:F309	6.766	5	1	5
33	R:R:F312	6.672	5	0	7
34	R:R:Y313	11.8175	4	1	7
35	R:R:Y323	5.51	5	2	9
36	R:R:Y330	9.615	4	0	8
37	L:L:?3	8.74143	7	1	0
38	L:L:F4	7.0225	4	1	0
39	L:L:L5	5.045	4	3	0
40	L:L:H9	6.285	4	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F309	R:R:Y313	10.6919	13.41	Yes	Yes	1	5	7
2	R:R:F312	R:R:Y313	62.9818	11.35	Yes	Yes	0	7	7
3	R:R:F312	R:R:W276	63.7761	4.01	Yes	Yes	0	7	8
4	R:R:F272	R:R:W276	100	19.04	Yes	Yes	7	9	8
5	R:R:F272	R:R:I134	75.1414	6.28	Yes	Yes	0	9	8
6	R:R:I134	R:R:Y323	63.2322	4.84	Yes	Yes	0	8	9
7	R:R:V268	R:R:Y323	12.6775	3.79	No	Yes	0	8	9
8	L:L:S2	R:R:F309	11.279	6.61	No	Yes	0	0	5
9	L:L:S2	R:R:F279	11.4775	5.28	No	Yes	0	0	6
10	R:R:F279	R:R:W276	49.8295	5.01	Yes	Yes	0	6	8
11	R:R:M96	R:R:Y313	16.8775	16.76	Yes	Yes	0	7	7
12	R:R:D89	R:R:K130	11.5552	12.44	Yes	No	0	9	9
13	R:R:K130	R:R:W276	15.0947	3.48	No	Yes	0	9	8
14	R:R:L82	R:R:Y323	31.683	5.86	No	Yes	2	8	9
15	R:R:L82	R:R:N324	32.6628	4.12	No	No	0	8	7
16	R:R:N324	R:R:Y330	31.4197	22.1	No	Yes	0	7	8
17	R:R:F71	R:R:V67	19.7479	3.93	Yes	No	0	5	8
18	R:R:V334	R:R:V67	20.9479	3.21	No	No	0	6	8
19	R:R:V334	R:R:Y330	27.5608	8.83	No	Yes	0	6	8
20	R:R:E73	R:R:F71	11.4948	2.33	No	Yes	0	6	5
21	R:R:E73	R:R:L74	10.0876	5.3	No	No	0	6	8
22	R:R:L137	R:R:Y323	26.1406	5.86	Yes	Yes	2	8	9
23	R:R:L137	R:R:Y81	25.9205	3.52	Yes	Yes	2	8	8
24	R:R:I134	R:R:M85	11.2229	4.37	Yes	Yes	0	8	9
25	R:R:F87	R:R:W168	15.9192	5.01	No	Yes	0	6	9
26	R:R:F172	R:R:W168	24.8284	5.01	No	Yes	0	4	9
27	R:R:F121	R:R:F172	29.2312	5.36	Yes	No	0	6	4
28	R:R:F121	R:R:I178	37.5879	3.77	Yes	No	0	6	4
29	R:R:I178	R:R:Q120	39.28	4.12	No	Yes	1	4	4
30	R:R:Q120	R:R:R102	22.9853	8.18	Yes	Yes	1	4	5
31	R:R:D99	R:R:R102	48.5475	4.76	Yes	Yes	1	6	5
32	R:R:D99	R:R:F309	29.4384	3.58	Yes	Yes	1	6	5
33	R:R:F119	R:R:Q120	20.8486	14.05	Yes	Yes	1	4	4
34	R:R:D99	R:R:F119	37.8038	8.36	Yes	Yes	1	6	4
35	R:R:F87	R:R:L91	13.6703	10.96	No	Yes	0	6	7
36	R:R:R102	R:R:Y106	26.6284	11.32	Yes	No	0	5	3
37	R:R:E197	R:R:Y106	25.4932	4.49	Yes	No	0	4	3
38	L:L:?3	L:L:F4	29.1449	9.33	Yes	Yes	1	0	0
39	L:L:?3	R:R:R283	31.8427	13.97	Yes	No	1	0	6
40	R:R:I134	R:R:L228	12.889	4.28	Yes	No	0	8	8
41	R:R:F272	R:R:P224	57.3877	5.78	Yes	No	0	9	9
42	R:R:P224	R:R:T135	53.969	5.25	No	No	0	9	7
43	R:R:C227	R:R:T135	52.8122	3.38	No	No	0	6	7
44	R:R:L228	R:R:Y232	10.2905	3.52	No	Yes	8	8	9
45	R:R:L231	R:R:Y142	49.2899	16.41	No	Yes	0	7	8
46	R:R:C227	R:R:L231	51.6467	3.17	No	No	0	6	7
47	R:R:C146	R:R:Y142	26.6154	9.41	No	Yes	0	7	8
48	R:R:F147	R:R:Y142	11.6459	5.16	No	Yes	0	6	8
49	L:L:?3	R:R:F286	41.1102	9.33	Yes	Yes	0	0	4
50	R:R:F286	R:R:F290	10.5624	10.72	Yes	Yes	0	4	1
51	R:R:F286	R:R:L210	10.8732	4.87	Yes	No	0	4	3
52	R:R:F221	R:R:H280	16.6444	13.58	No	No	0	8	7
53	R:R:F279	R:R:H280	17.9652	4.53	Yes	No	0	6	7
54	R:R:F221	R:R:L277	12.6559	7.31	No	No	0	8	6
55	R:R:V269	R:R:Y232	11.1322	5.05	No	Yes	0	8	9
56	R:R:C146	R:R:K238	25.2558	3.23	No	No	0	7	5
57	R:R:K238	R:R:R242	24.0169	4.95	No	No	0	5	5
58	R:R:R242	R:R:R243	22.6529	4.26	No	No	0	5	3
59	R:R:D255	R:R:R243	14.1883	3.57	No	No	11	1	3
60	R:R:D255	R:R:N257	13.0919	8.08	No	No	0	1	5
61	R:R:N257	R:R:Q256	11.6588	3.96	No	No	0	5	4
62	R:R:Q256	R:R:Q260	10.2171	6.4	No	No	0	4	7
63	L:L:?3	R:R:N305	11.443	12.63	Yes	No	0	0	4
64	L:L:L5	R:R:F286	13.1221	4.87	Yes	Yes	0	0	4
65	L:L:H9	L:L:R11	10.666	9.03	Yes	No	0	0	0
66	R:R:D99	R:R:Y313	57.461	5.75	Yes	Yes	1	6	7
67	L:L:F4	R:R:F309	29.4427	5.36	Yes	Yes	1	0	5
68	R:R:F279	R:R:R283	35.5463	13.9	Yes	No	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L103	R:R:L43	4.15	1	No	No	4	5	1	2
R:R:D99	R:R:F309	3.58	1	Yes	Yes	6	5	2	1
R:R:D99	R:R:Y313	5.75	1	Yes	Yes	6	7	2	2
R:R:F309	R:R:L103	4.87	1	Yes	No	5	4	1	1
L:L:F4	R:R:L103	10.96	1	Yes	No	0	4	0	1
R:R:E197	R:R:Y106	4.49	0	Yes	No	4	3	1	2
R:R:E197	R:R:R107	5.82	0	Yes	No	4	4	1	1
L:L:E8	R:R:R107	13.96	0	No	No	0	4	0	1
R:R:E124	R:R:Y128	7.86	1	No	Yes	4	6	1	1
R:R:E124	R:R:R283	11.63	1	No	No	4	6	1	1
L:L:?3	R:R:E124	7.11	1	Yes	No	0	4	0	1
R:R:S217	R:R:Y128	8.9	0	No	Yes	6	6	2	1
R:R:F220	R:R:Y128	28.88	0	No	Yes	6	6	2	1
L:L:?3	R:R:Y128	4.49	1	Yes	Yes	0	6	0	1
R:R:M213	R:R:P177	8.39	0	No	No	5	7	1	2
L:L:E8	R:R:E187	3.81	0	No	No	0	3	0	1
R:R:E197	R:R:T195	5.64	0	Yes	No	4	3	1	2
R:R:E197	R:R:R199	5.82	0	Yes	No	4	3	1	2
L:L:S6	R:R:E197	4.31	0	No	Yes	0	4	0	1
R:R:F286	R:R:P200	4.33	0	Yes	No	4	4	1	2
R:R:F290	R:R:V205	15.73	3	Yes	No	1	4	1	2
R:R:F286	R:R:L210	4.87	0	Yes	No	4	3	1	2
L:L:?3	R:R:M213	4.33	1	Yes	No	0	5	0	1
R:R:F279	R:R:W276	5.01	0	Yes	Yes	6	8	1	2
R:R:F279	R:R:H280	4.53	0	Yes	No	6	7	1	2
R:R:F279	R:R:R283	13.9	0	Yes	No	6	6	1	1
L:L:S2	R:R:F279	5.28	0	No	Yes	0	6	0	1
R:R:G282	R:R:N305	5.09	0	No	No	4	4	2	1
L:L:?3	R:R:R283	13.97	1	Yes	No	0	6	0	1
R:R:F286	R:R:F290	10.72	0	Yes	Yes	4	1	1	1
L:L:?3	R:R:F286	9.33	1	Yes	Yes	0	4	0	1
L:L:L5	R:R:F286	4.87	3	Yes	Yes	0	4	0	1
R:R:F290	R:R:S289	5.28	3	Yes	No	1	2	1	1
L:L:L5	R:R:S289	7.51	3	Yes	No	0	2	0	1
L:L:H9	R:R:S289	4.18	3	Yes	No	0	2	0	1
L:L:H9	R:R:F290	6.79	3	Yes	Yes	0	1	0	1
R:R:E291	R:R:P292	4.72	0	No	No	1	2	2	1
L:L:R11	R:R:P292	4.32	0	No	No	0	2	0	1
R:R:N305	R:R:S301	5.96	0	No	No	4	4	1	2
R:R:Q302	R:R:Y303	3.38	0	No	No	3	1	1	2
L:L:?3	R:R:N305	12.63	1	Yes	No	0	4	0	1
R:R:F309	R:R:Y313	13.41	1	Yes	Yes	5	7	1	2
L:L:S2	R:R:F309	6.61	0	No	Yes	0	5	0	1
L:L:F4	R:R:F309	5.36	1	Yes	Yes	0	5	0	1
L:L:G1	R:R:F279	3.01	0	No	Yes	0	6	0	1
L:L:L5	R:R:Q302	2.66	3	Yes	No	0	3	0	1
R:R:E187	R:R:Q188	2.55	0	No	No	3	3	1	2
L:L:F4	R:R:L306	2.44	1	Yes	No	0	4	0	1
R:R:G293	R:R:P292	2.03	0	No	No	2	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7NA7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.38
Number of Linked Nodes	285
Number of Links	316
Number of Hubs	40
Number of Links mediated by Hubs	154
Number of Communities	11
Number of Nodes involved in Communities	51
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	51706
Length Of Smallest Path	3
Average Path Length	13.1769
Length of Longest Path	33
Minimum Path Strength	1.31
Average Path Strength	6.98451
Maximum Path Strength	18.89
Minimum Path Correlation	0.7
Average Path Correlation	0.927836
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	52.2557
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.6726
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • protein tyrosine kinase activator activity • enzyme regulator activity • kinase activator activity • enzyme activator activity • molecular function activator activity • molecular function regulator activity • protein kinase activator activity • protein kinase regulator activity • kinase regulator activity • ghrelin receptor binding • signaling receptor binding • G protein-coupled receptor binding • hormone activity • growth hormone-releasing hormone activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • skeletal system development • connective tissue development • tissue development • cartilage development • digestive system process • regulation of system process • regulation of gastric motility • regulation of digestive system process • digestion • gastric motility • regulation of multicellular organismal process • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • interleukin-6 production • regulation of interleukin-6 production • negative regulation of interleukin-6 production • intestinal motility • positive regulation of small intestinal transit • positive regulation of biological process • positive regulation of digestive system process • positive regulation of multicellular organismal process • small intestinal transit • regulation of small intestinal transit • positive regulation of blood circulation • gastric mucosal blood circulation • regulation of gastric mucosal blood circulation • circulatory system process • regulation of blood circulation • positive regulation of gastric mucosal blood circulation • blood circulation • regulation of circadian sleep/wake cycle • negative regulation of circadian sleep/wake cycle, REM sleep • regulation of circadian rhythm • regulation of behavior • sleep • circadian sleep/wake cycle, sleep • rhythmic process • negative regulation of behavior • circadian sleep/wake cycle • rhythmic behavior • circadian rhythm • regulation of circadian sleep/wake cycle, REM sleep • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of circadian rhythm • behavior • circadian behavior • circadian sleep/wake cycle, REM sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • regulation of multicellular organismal development • regulation of developmental process • regulation of bone development • positive regulation of developmental process • positive regulation of bone development • bone development • positive regulation of growth • regulation of growth • growth • positive regulation of growth rate • regulation of growth rate • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • primary metabolic process • glucose metabolic process • response to electrical stimulus • response to abiotic stimulus • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • regulation of cell communication • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of epithelial cell proliferation • regulation of vascular endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of cell population proliferation • positive regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • vascular endothelial cell proliferation • epithelial cell proliferation • positive regulation of vascular endothelial cell proliferation • positive regulation of cellular process • positive regulation of cell communication • regulation of localization • nitrogen compound transport • localization • regulation of biological quality • regulation of peptide hormone secretion • positive regulation of corticotropin secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • regulation of endocrine process • regulation of hormone secretion • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • regulation of corticotropin secretion • peptide secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of peptide secretion • secretion • regulation of transport • corticotropin secretion • regulation of peptide transport • export from cell • peptide transport • endocrine process • positive regulation of transport • peptide hormone secretion • hormone transport • positive regulation of signaling • nervous system development • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • regulation of cellular component organization • postsynapse organization • regulation of postsynapse organization • regulation of synapse organization • regulation of synapse structure or activity • steroid hormone secretion • organic hydroxy compound transport • cortisol secretion • lipid localization • lipid transport • lipid export from cell • macromolecule localization • glucocorticoid secretion • corticosteroid hormone secretion • positive regulation of signal transduction • response to peptide hormone • regulation of signal transduction • cellular response to growth hormone stimulus • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of response to stimulus • regulation of growth hormone receptor signaling pathway • enzyme-linked receptor protein signaling pathway • growth hormone receptor signaling pathway • cell surface receptor signaling pathway • cellular response to peptide hormone stimulus • response to growth hormone • regulation of response to stimulus • positive regulation of growth hormone receptor signaling pathway • adult feeding behavior • adult behavior • feeding behavior • actin polymerization or depolymerization • organelle organization • actin cytoskeleton organization • actin filament organization • actin filament-based process • supramolecular fiber organization • cytoskeleton organization • positive regulation of smooth muscle contraction • intestine smooth muscle contraction • regulation of gastro-intestinal system smooth muscle contraction • positive regulation of small intestine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of small intestine smooth muscle contraction • small intestine smooth muscle contraction • gastro-intestinal system smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • positive regulation of gastro-intestinal system smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • response to nutrient levels • regulation of response to nutrient levels • regulation of response to food • response to food • positive regulation of steroid hormone secretion • regulation of glucocorticoid secretion • positive regulation of cortisol secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • positive regulation of corticosteroid hormone secretion • regulation of corticosteroid hormone secretion • positive regulation of lipid transport • regulation of cortisol secretion • regulation of lipid transport • positive regulation of lipid localization • regulation of lipid localization • acid secretion • gastric acid secretion • positive regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • positive regulation of cellular component organization • regulation of nervous system development • regulation of synapse assembly • positive regulation of cellular component biogenesis • regulation of cellular component biogenesis • regulation of cell junction assembly • positive regulation of cell junction assembly • positive regulation of synapse assembly • response to estrogen • adipose tissue development • positive regulation of adipose tissue development • regulation of adipose tissue development • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • hormone-mediated signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • regulation of circadian sleep/wake cycle, non-REM sleep • circadian sleep/wake cycle, non-REM sleep • positive regulation of circadian sleep/wake cycle, non-REM sleep • positive regulation of behavior • positive regulation of circadian rhythm • positive regulation of circadian sleep/wake cycle, sleep • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of interleukin-1 production • interleukin-1 beta production • positive regulation of appetite • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • negative regulation of protein transport • establishment of protein localization • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • insulin secretion • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • excitatory postsynaptic potential • regulation of membrane potential • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • positive regulation of protein transport • response to monosaccharide • response to carbohydrate • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • cellular response to glucose stimulus • positive regulation of protein secretion • response to hexose • cellular homeostasis • regulation of cellular localization • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • generation of neurons • neurogenesis • neuron differentiation • dendrite development • cell differentiation • neuron development • multi-multicellular organism process • placenta development • reproductive process • maternal process involved in female pregnancy • multicellular organismal reproductive process • developmental process involved in reproduction • maternal placenta development • female pregnancy • multi-organism reproductive process • decidualization • regulation of multicellular organism growth • regulation of developmental growth • developmental growth • positive regulation of multicellular organism growth • multicellular organism growth • positive regulation of developmental growth • regulation of sprouting angiogenesis • angiogenesis • regulation of vasculature development • tube morphogenesis • positive regulation of sprouting angiogenesis • regulation of anatomical structure morphogenesis • blood vessel development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • sprouting angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • negative regulation of locomotion • regulation of locomotion • locomotion • regulation of eating behavior • positive regulation of feeding behavior • eating behavior • positive regulation of eating behavior • regulation of feeding behavior • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • growth hormone secretion • regulation of growth hormone secretion • positive regulation of growth hormone secretion • negative regulation of cell population proliferation • negative regulation of endothelial cell proliferation • negative regulation of epithelial cell proliferation • transmission of nerve impulse • regulation of nervous system process • regulation of transmission of nerve impulse • glutamatergic synapse • endoplasmic reticulum lumen • endoplasmic reticulum • axon • postsynapse • intracellular vesicle • cytoplasmic vesicle lumen • cytoplasmic vesicle • neuronal dense core vesicle lumen • neuronal dense core vesicle • vesicle lumen • dense core granule • secretory granule lumen • secretory granule • dense core granule lumen • secretory vesicle • Schaffer collateral - CA1 synapse • molecular transducer activity • growth hormone secretagogue receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • amide binding • peptide hormone binding • hormone binding • identical protein binding • growth hormone-releasing hormone receptor activity • cellular response to insulin-like growth factor stimulus • spermatogenesis • sexual reproduction • male gamete generation • gamete generation • locomotion involved in locomotory behavior • negative regulation of locomotion involved in locomotory behavior • locomotory behavior • regulation of locomotion involved in locomotory behavior • insulin-like growth factor receptor signaling pathway • positive regulation of insulin-like growth factor receptor signaling pathway • regulation of insulin-like growth factor receptor signaling pathway • response to glucocorticoid • response to corticosteroid • response to steroid hormone • response to dexamethasone • response to thyroid hormone • cellular response to thyroid hormone stimulus • response to acid chemical • response to L-glutamate • response to amino acid • response to gonadotropin • response to follicle-stimulating hormone • regulation of hindgut contraction • hindgut contraction • leukocyte apoptotic process • macrophage apoptotic process • negative regulation of leukocyte apoptotic process • myeloid cell apoptotic process • regulation of leukocyte apoptotic process • negative regulation of macrophage apoptotic process • regulation of macrophage apoptotic process • inflammatory cell apoptotic process • negative regulation of myeloid cell apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of appetite • oxoacid metabolic process • ketone metabolic process • regulation of lipid metabolic process • organic acid metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • positive regulation of fatty acid metabolic process • fatty acid metabolic process • carboxylic acid metabolic process • regulation of ketone metabolic process • regulation of fatty acid metabolic process • monocarboxylic acid metabolic process • positive regulation of small molecule metabolic process • lipid metabolic process • biological process involved in interspecies interaction between organisms • response to other organism • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • ghrelin secretion • protein localization to synapse • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane • regulation of protein localization to synapse • neurotransmitter receptor localization to postsynaptic specialization membrane • regulation of protein localization to membrane • regulation of receptor localization to synapse • protein localization to postsynaptic specialization membrane • protein localization to cell periphery • protein localization to postsynaptic membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • protein-containing complex localization • regulation of postsynaptic membrane neurotransmitter receptor levels • protein localization to organelle • protein localization to postsynapse • protein localization to cell junction • receptor localization to synapse • learning or memory • cognition • response to insulin • cellular response to insulin stimulus • monoamine transport • negative regulation of amine transport • regulation of catecholamine secretion • catecholamine transport • negative regulation of norepinephrine secretion • norepinephrine transport • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • response to estradiol • plasma membrane region • synaptic membrane • cell surface • membrane microdomain • membrane raft
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	1IC
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	1IC
Name	O-octanoyl-D-serine
Synonyms
Identifier
Formula	C11 H21 N O4
Molecular Weight	231.289
SMILES
PubChem	162368291
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	1
Total Bonds	36
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92847
Sequence	>7NA7_nogp_Chain_R P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F R E L R T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y R P W N F G D L L C K L F Q F V S E S C T Y A K V L T I T A L S V E R Y F A I C F P L R A K V V V T K G R V K L V I F V I W A V A F C S A G P I F V L V G V E H E Q G T D P W D T N E C R P T E F A V R S G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E P G S L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K Y R V A V F R L L G F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KO5	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 57400002	-	-	3.3	2020-08-12	doi.org/10.1038/s41467-020-17554-1
	7F9Y	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Y (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-		2.9	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-		3.2	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7NA7	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-	Gi1/β1/γ2	2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA7 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-		2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA8	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-	Gi1/β1/γ2	2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA8 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-		2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7F83	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PF-05190457	-	-	2.94	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	7W2Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-	Go/β1/γ2	2.8	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	7W2Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-		2.8	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	8JSR	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	8JSR (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	9UY3	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.52	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9UY3 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.52	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-		2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7

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