psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D99	7.79	Yes	No	1	0	6
2	L:L:?1	R:R:R102	10.15	Yes	Yes	1	0	5
3	L:L:?1	R:R:Q120	7.64	Yes	Yes	1	0	4
4	L:L:?1	R:R:S123	6.27	Yes	No	0	0	6
5	L:L:?1	R:R:E124	6.92	Yes	Yes	1	0	4
6	L:L:?1	R:R:L210	4.34	Yes	No	0	0	3
7	L:L:?1	R:R:F279	4.45	Yes	Yes	1	0	6
8	L:L:?1	R:R:R283	18.39	Yes	Yes	1	0	6
9	L:L:?1	R:R:F286	7.63	Yes	Yes	0	0	4
10	L:L:?1	R:R:F309	7.63	Yes	Yes	1	0	5
11	L:L:?1	R:R:F312	5.72	Yes	Yes	1	0	7
12	R:R:L100	R:R:T47	7.37	No	No	0	7	6
13	R:R:C50	R:R:F309	4.19	No	Yes	0	6	5
14	R:R:L314	R:R:L53	4.15	No	No	0	5	7
15	R:R:F54	R:R:I58	6.28	Yes	Yes	2	7	6
16	R:R:F54	R:R:F93	5.36	Yes	Yes	2	7	6
17	R:R:F54	R:R:M96	12.44	Yes	No	0	7	7
18	R:R:F93	R:R:G57	4.52	Yes	No	0	6	8
19	R:R:F93	R:R:I58	3.77	Yes	Yes	2	6	6
20	R:R:A86	R:R:N61	4.69	No	No	0	9	9
21	R:R:D89	R:R:N61	8.08	Yes	No	0	9	9
22	R:R:N61	R:R:P320	8.15	No	No	0	9	9
23	R:R:L63	R:R:V334	4.47	No	No	0	6	6
24	R:R:N324	R:R:T64	5.85	No	No	3	7	9
25	R:R:T64	R:R:Y330	3.75	No	Yes	3	9	8
26	R:R:F87	R:R:M65	3.73	No	No	0	6	7
27	R:R:V67	R:R:Y330	5.05	No	Yes	0	8	8
28	R:R:N79	R:R:V68	5.91	No	No	0	8	7
29	R:R:F71	R:R:R70	4.28	No	No	0	5	5
30	R:R:A333	R:R:F71	4.16	No	No	0	6	5
31	R:R:R72	R:R:R75	8.53	No	No	0	6	7
32	R:R:E73	R:R:L74	3.98	No	No	0	6	8
33	R:R:K329	R:R:L74	5.64	No	No	0	6	8
34	R:R:N79	R:R:T76	7.31	No	No	0	8	7
35	R:R:E140	R:R:T77	9.88	No	Yes	0	9	7
36	R:R:K157	R:R:T77	9.01	No	Yes	0	3	7
37	R:R:T77	R:R:V160	7.93	Yes	No	0	7	7
38	R:R:E140	R:R:T78	5.64	No	No	0	9	8
39	R:R:A136	R:R:Y81	5.34	No	Yes	0	7	8
40	R:R:L137	R:R:Y81	8.21	No	Yes	0	8	8
41	R:R:E140	R:R:Y81	8.98	No	Yes	0	9	8
42	R:R:V160	R:R:Y81	6.31	No	Yes	0	7	8
43	R:R:V163	R:R:Y81	6.31	No	Yes	0	6	8
44	R:R:L137	R:R:L82	5.54	No	No	0	8	8
45	R:R:L82	R:R:Y323	5.86	No	No	0	8	9
46	R:R:L82	R:R:N324	6.87	No	No	0	8	7
47	R:R:I164	R:R:S84	4.64	No	No	0	7	9
48	R:R:S84	R:R:W168	6.18	No	Yes	0	9	9
49	R:R:M85	R:R:T130	6.02	Yes	No	0	9	9
50	R:R:M85	R:R:T133	7.53	Yes	No	0	9	8
51	R:R:I134	R:R:M85	4.37	Yes	Yes	1	8	9
52	R:R:M85	R:R:N319	4.21	Yes	Yes	1	9	9
53	R:R:F87	R:R:L91	9.74	No	No	0	6	7
54	R:R:S88	R:R:T130	4.8	No	No	0	8	9
55	R:R:S88	R:R:W168	7.41	No	Yes	0	8	9
56	R:R:D89	R:R:T130	5.78	Yes	No	0	9	9
57	R:R:A316	R:R:D89	4.63	No	Yes	0	9	9
58	R:R:D89	R:R:N319	8.08	Yes	Yes	0	9	9
59	R:R:L91	R:R:V122	4.47	No	No	0	7	5
60	R:R:C126	R:R:L91	6.35	No	No	0	8	7
61	R:R:F312	R:R:I92	6.28	Yes	No	0	7	7
62	R:R:A316	R:R:F93	5.55	No	Yes	0	9	6
63	R:R:C95	R:R:F119	5.59	No	No	0	6	4
64	R:R:M96	R:R:Y313	16.76	No	Yes	0	7	7
65	R:R:F119	R:R:L98	9.74	No	No	0	4	5
66	R:R:D99	R:R:F309	11.94	No	Yes	1	6	5
67	R:R:D99	R:R:Y313	10.34	No	Yes	1	6	7
68	R:R:R102	R:R:W109	4	Yes	Yes	1	5	7
69	R:R:Q120	R:R:R102	5.84	Yes	Yes	1	4	5
70	R:R:E197	R:R:R102	4.65	No	Yes	0	4	5
71	R:R:F309	R:R:L103	8.53	Yes	No	0	5	4
72	R:R:W104	R:R:Y106	35.69	No	No	0	4	3
73	R:R:R107	R:R:W104	7	No	No	0	4	4
74	R:R:E197	R:R:Q105	6.37	No	No	0	4	4
75	R:R:N110	R:R:P108	6.52	No	No	0	3	4
76	R:R:F111	R:R:W109	8.02	No	Yes	0	6	7
77	R:R:C116	R:R:W109	5.22	No	Yes	1	9	7
78	R:R:C198	R:R:W109	13.06	No	Yes	1	9	7
79	R:R:D113	R:R:L114	5.43	No	No	0	4	4
80	R:R:D113	R:R:K117	9.68	No	No	0	4	7
81	R:R:D113	R:R:V184	5.84	No	No	0	4	5
82	R:R:C116	R:R:K117	6.47	No	No	0	9	7
83	R:R:C116	R:R:C198	5.46	No	No	1	9	9
84	R:R:F179	R:R:K117	4.96	No	No	0	5	7
85	R:R:F119	R:R:Q120	10.54	No	Yes	0	4	4
86	R:R:Q120	R:R:V182	8.6	Yes	No	0	4	4
87	R:R:C198	R:R:Q120	4.58	No	Yes	1	9	4
88	R:R:F121	R:R:S125	7.93	Yes	No	4	6	5
89	R:R:F121	R:R:F172	6.43	Yes	No	4	6	4
90	R:R:F121	R:R:F179	15	Yes	No	0	6	5
91	R:R:E124	R:R:Y128	14.59	Yes	Yes	1	4	6
92	R:R:E124	R:R:I178	6.83	Yes	No	0	4	4
93	R:R:E124	R:R:R283	10.47	Yes	Yes	1	4	6
94	R:R:F172	R:R:S125	6.61	No	No	4	4	5
95	R:R:F312	R:R:T127	9.08	Yes	No	0	7	7
96	R:R:S174	R:R:Y128	7.63	No	Yes	1	5	6
97	R:R:S217	R:R:Y128	5.09	No	Yes	0	6	6
98	R:R:F220	R:R:Y128	25.79	Yes	Yes	1	6	6
99	R:R:A129	R:R:W168	7.78	No	Yes	0	6	9
100	R:R:P224	R:R:V131	5.3	Yes	No	1	9	8
101	R:R:F272	R:R:V131	3.93	Yes	No	1	9	8
102	R:R:V131	R:R:W276	3.68	No	Yes	1	8	8
103	R:R:I167	R:R:L132	7.14	No	No	0	7	6
104	R:R:F220	R:R:L132	6.09	Yes	No	0	6	6
105	R:R:I134	R:R:L228	4.28	Yes	No	0	8	8
106	R:R:F272	R:R:I134	5.02	Yes	Yes	1	9	8
107	R:R:I134	R:R:N319	4.25	Yes	Yes	1	8	9
108	R:R:I134	R:R:Y323	7.25	Yes	No	0	8	9
109	R:R:L228	R:R:S138	4.5	No	No	0	8	9
110	R:R:L231	R:R:S138	4.5	Yes	No	0	7	9
111	R:R:S138	R:R:Y232	6.36	No	Yes	0	9	9
112	R:R:R141	R:R:Y232	8.23	No	Yes	0	9	9
113	R:R:R141	R:R:Y323	6.17	No	No	0	9	9
114	R:R:C146	R:R:Y142	9.41	No	Yes	0	7	8
115	R:R:F147	R:R:Y142	4.13	No	Yes	0	6	8
116	R:R:L231	R:R:Y142	17.58	Yes	Yes	0	7	8
117	R:R:L234	R:R:Y142	7.03	No	Yes	0	5	8
118	R:R:F143	R:R:R150	7.48	No	No	0	5	5
119	R:R:I145	R:R:I235	5.89	No	No	0	9	8
120	R:R:I145	R:R:L239	4.28	No	No	0	9	8
121	R:R:F147	R:R:R150	5.34	No	No	0	6	5
122	R:R:V155	R:R:V163	4.81	No	No	0	7	6
123	R:R:R159	R:R:T156	6.47	No	No	0	5	7
124	R:R:F165	R:R:K161	3.72	No	No	0	4	3
125	R:R:F172	R:R:W168	4.01	No	Yes	0	4	9
126	R:R:F220	R:R:S174	6.61	Yes	No	1	6	5
127	R:R:G176	R:R:P177	4.06	No	No	0	4	7
128	R:R:L181	R:R:M213	5.65	No	No	0	4	5
129	R:R:E185	R:R:R199	9.3	No	No	0	1	3
130	R:R:E185	R:R:T201	4.23	No	No	0	1	3
131	R:R:H186	R:R:T195	5.48	No	No	0	2	3
132	R:R:H186	R:R:N196	3.83	No	No	0	2	4
133	R:R:E197	R:R:R199	4.65	No	No	0	4	3
134	R:R:L210	R:R:P200	4.93	No	No	0	3	4
135	R:R:F286	R:R:P200	5.78	Yes	No	0	4	4
136	R:R:E202	R:R:R206	13.96	No	No	0	6	1
137	R:R:F203	R:R:S207	7.93	No	No	0	6	3
138	R:R:F290	R:R:V205	18.35	No	No	0	1	4
139	R:R:L210	R:R:S287	4.5	No	No	0	3	4
140	R:R:T211	R:R:W215	6.06	No	No	0	4	4
141	R:R:S287	R:R:T211	4.8	No	No	0	4	4
142	R:R:V214	R:R:W215	3.68	No	No	0	5	4
143	R:R:W215	R:R:Y284	4.82	No	No	0	4	5
144	R:R:H280	R:R:S217	5.58	No	No	0	7	6
145	R:R:R283	R:R:S217	7.91	Yes	No	0	6	6
146	R:R:F222	R:R:S218	7.93	No	No	0	4	4
147	R:R:F221	R:R:F222	4.29	Yes	No	0	8	4
148	R:R:F221	R:R:V225	7.87	Yes	No	0	8	6
149	R:R:F221	R:R:L277	8.53	Yes	No	0	8	6
150	R:R:F221	R:R:H280	9.05	Yes	No	0	8	7
151	R:R:F272	R:R:P224	5.78	Yes	Yes	1	9	9
152	R:R:I273	R:R:V225	4.61	No	No	0	6	6
153	R:R:F226	R:R:V230	5.24	No	No	0	3	4
154	R:R:L265	R:R:Y232	11.72	No	Yes	0	8	9
155	R:R:V268	R:R:Y232	3.79	No	Yes	0	8	9
156	R:R:V269	R:R:Y232	5.05	No	Yes	0	8	9
157	R:R:L234	R:R:R237	4.86	No	No	0	5	4
158	R:R:G236	R:R:V262	5.52	No	No	0	5	7
159	R:R:R237	R:R:R241	11.73	No	No	0	4	5
160	R:R:H258	R:R:L239	9	No	No	0	6	8
161	R:R:V262	R:R:W240	3.68	No	No	0	7	4
162	R:R:M264	R:R:V267	7.61	No	No	0	8	6
163	R:R:M264	R:R:M326	5.78	No	No	0	8	7
164	R:R:F272	R:R:W276	18.04	Yes	Yes	1	9	8
165	R:R:C275	R:R:W276	3.92	No	Yes	1	9	8
166	R:R:C275	R:R:S315	6.89	No	No	1	9	9
167	R:R:F279	R:R:W276	10.02	Yes	Yes	1	6	8
168	R:R:F312	R:R:W276	4.01	Yes	Yes	1	7	8
169	R:R:S315	R:R:W276	8.65	No	Yes	1	9	8
170	R:R:L311	R:R:P278	4.93	No	No	0	7	9
171	R:R:F279	R:R:H280	11.31	Yes	No	0	6	7
172	R:R:F279	R:R:R283	11.76	Yes	Yes	1	6	6
173	R:R:F279	R:R:F312	8.57	Yes	Yes	1	6	7
174	R:R:C304	R:R:G282	3.92	No	No	0	5	4
175	R:R:L285	R:R:Y284	5.86	Yes	No	0	4	5
176	R:R:K288	R:R:Y284	9.55	No	No	0	4	5
177	R:R:I297	R:R:L285	4.28	No	Yes	0	1	4
178	R:R:I300	R:R:L285	4.28	No	Yes	0	2	4
179	R:R:F286	R:R:F290	7.5	Yes	No	0	4	1
180	R:R:I297	R:R:S289	4.64	No	No	0	1	2
181	R:R:S289	R:R:S301	4.89	No	No	0	2	4
182	R:R:E291	R:R:P292	6.29	No	No	0	1	2
183	R:R:I297	R:R:S294	4.64	No	No	0	1	6
184	R:R:F309	R:R:Y313	12.38	Yes	Yes	1	5	7
185	R:R:F312	R:R:Y313	11.35	Yes	Yes	1	7	7
186	R:R:N319	R:R:S315	4.47	Yes	No	1	9	9
187	R:R:I318	R:R:L322	4.28	No	No	0	7	8
188	R:R:I321	R:R:I325	5.89	No	No	0	6	6
189	R:R:N324	R:R:Y330	20.93	No	Yes	3	7	8
190	R:R:K329	R:R:S327	6.12	No	No	0	6	8
191	R:R:K328	R:R:R331	4.95	No	No	0	5	8
192	R:R:F309	R:R:L100	3.65	Yes	No	0	5	7
193	R:R:F270	R:R:L274	3.65	No	No	0	5	5
194	R:R:I235	R:R:Y142	3.63	No	Yes	0	8	8
195	R:R:F286	R:R:N305	3.62	Yes	No	0	4	4
196	R:R:E73	R:R:F71	3.5	No	No	0	6	5
197	R:R:P224	R:R:T135	3.5	Yes	No	0	9	7
198	R:R:G158	R:R:K157	3.49	No	No	0	4	3
199	R:R:C95	R:R:V122	3.42	No	No	0	6	5
200	R:R:G112	R:R:L115	3.42	No	No	0	8	5
201	R:R:A175	R:R:S125	3.42	No	No	0	7	5
202	R:R:G282	R:R:L285	3.42	No	Yes	0	4	4
203	R:R:A298	R:R:S289	3.42	No	No	0	3	2
204	R:R:C227	R:R:T135	3.38	No	No	0	6	7
205	R:R:L223	R:R:P224	3.28	No	Yes	0	5	9
206	R:R:L277	R:R:P278	3.28	No	No	0	6	9
207	R:R:C146	R:R:K238	3.23	No	No	0	7	5
208	R:R:F203	R:R:R206	3.21	No	No	0	6	1
209	R:R:A317	R:R:L53	3.15	No	No	0	7	7
210	R:R:T76	R:R:T78	3.14	No	No	0	7	8
211	R:R:F121	R:R:G176	3.01	Yes	No	0	6	4
212	R:R:L306	R:R:V46	2.98	No	No	0	4	4
213	R:R:L80	R:R:V160	2.98	No	No	0	5	7
214	R:R:L132	R:R:V170	2.98	No	No	0	6	4
215	R:R:L231	R:R:V139	2.98	Yes	No	0	7	7
216	R:R:L209	R:R:V212	2.98	No	No	0	4	6
217	R:R:L322	R:R:V268	2.98	No	No	0	8	8
218	R:R:L277	R:R:V281	2.98	No	No	0	6	7
219	R:R:L285	R:R:V281	2.98	Yes	No	0	4	7
220	R:R:L311	R:R:V307	2.98	No	No	0	7	5
221	L:L:?1	R:R:M213	2.95	Yes	No	0	0	5
222	R:R:L239	R:R:T261	2.95	No	No	0	8	8
223	R:R:F54	R:R:P97	2.89	Yes	No	0	7	7
224	R:R:E291	R:R:S294	2.87	No	No	0	1	6
225	R:R:I58	R:R:L62	2.85	Yes	No	0	6	3
226	R:R:I58	R:R:L90	2.85	Yes	No	0	6	7
227	R:R:I318	R:R:L314	2.85	No	No	0	7	5
228	R:R:L306	R:R:L42	2.77	No	No	0	4	3
229	R:R:L103	R:R:L306	2.77	No	No	0	4	4
230	R:R:L274	R:R:L311	2.77	No	No	0	5	7
231	R:R:F203	R:R:T201	2.59	No	No	0	6	3
232	R:R:S327	R:R:Y330	2.54	No	Yes	0	8	8
233	R:R:F179	R:R:L118	2.44	No	No	0	5	5
234	R:R:K263	R:R:W240	2.32	No	No	0	7	4
235	R:R:G60	R:R:P320	2.03	No	No	0	8	9
236	R:R:A44	R:R:G45	1.95	No	No	0	4	6
237	R:R:A48	R:R:G45	1.95	No	No	0	5	6
238	R:R:A59	R:R:G60	1.95	No	No	0	3	8
239	R:R:A40	R:R:P41	1.87	No	No	0	2	2
240	R:R:G57	R:R:V56	1.84	No	No	0	8	6
241	R:R:G183	R:R:V182	1.84	No	No	0	4	4
242	R:R:G158	R:R:T156	1.82	No	No	0	4	7
243	R:R:A129	R:R:A171	1.79	No	No	0	6	8
244	R:R:P278	R:R:S308	1.78	No	No	0	9	7
245	R:R:G236	R:R:I235	1.76	No	No	0	5	8
246	R:R:C50	R:R:V310	1.71	No	No	0	6	5
247	R:R:G60	R:R:L63	1.71	No	No	0	8	6
248	R:R:C50	R:R:T49	1.69	No	No	0	6	5
249	R:R:A204	R:R:T201	1.68	No	No	0	4	3
250	R:R:N196	R:R:P108	1.63	No	No	0	4	4
251	R:R:S83	R:R:V68	1.62	No	No	0	6	7
252	R:R:A271	R:R:I318	1.62	No	No	0	6	7
253	R:R:V55	R:R:V56	1.6	No	No	0	5	6
254	R:R:V154	R:R:V155	1.6	No	No	0	4	7
255	R:R:S233	R:R:T229	1.6	No	No	0	4	5
256	R:R:T47	R:R:V51	1.59	No	No	0	6	4
257	R:R:T229	R:R:V225	1.59	No	No	0	5	6
258	R:R:T229	R:R:V269	1.59	No	No	0	5	8
259	R:R:M213	R:R:V212	1.52	No	No	0	5	6
260	R:R:F111	R:R:G112	1.51	No	No	0	6	8
261	R:R:K152	R:R:T77	1.5	No	Yes	0	4	7
262	R:R:L162	R:R:V166	1.49	No	No	0	3	4
263	R:R:L231	R:R:V230	1.49	Yes	No	0	7	4
264	R:R:L234	R:R:V230	1.49	No	No	0	5	4
265	R:R:L322	R:R:V267	1.49	No	No	0	8	6
266	R:R:L43	R:R:T47	1.47	No	No	0	5	6
267	R:R:I325	R:R:M326	1.46	No	No	0	6	7
268	R:R:I164	R:R:K161	1.45	No	No	0	7	3
269	R:R:D194	R:R:T195	1.45	No	No	0	5	3
270	R:R:P108	R:R:R107	1.44	No	No	0	4	4
271	R:R:F147	R:R:P148	1.44	No	No	0	6	8
272	R:R:K259	R:R:K263	1.44	No	No	0	5	7
273	R:R:Q302	R:R:S301	1.44	No	No	0	3	4
274	R:R:I58	R:R:L94	1.43	Yes	No	0	6	5
275	R:R:K259	R:R:Q260	1.36	No	No	0	5	7
276	R:R:E296	R:R:L295	1.33	No	No	0	2	7
277	R:R:R75	R:R:V68	1.31	No	No	0	7	7
278	R:R:R102	R:R:V101	1.31	Yes	No	0	5	4
279	R:R:H258	R:R:N257	1.28	No	No	0	6	5
280	R:R:E296	R:R:Q299	1.27	No	No	0	2	1
281	R:R:F220	R:R:I219	1.26	Yes	No	0	6	5
282	R:R:L162	R:R:R159	1.21	No	No	0	3	5
283	R:R:L43	R:R:W104	1.14	No	No	0	5	4
284	R:R:Q302	R:R:Y303	1.13	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.49	12	1	0
2	R:R:F54	6.7425	4	2	7
3	R:R:I58	3.436	5	2	6
4	R:R:T77	7.08	4	0	7
5	R:R:Y81	7.03	5	0	8
6	R:R:M85	5.5325	4	1	9
7	R:R:D89	6.6425	4	0	9
8	R:R:F93	4.8	4	2	6
9	R:R:R102	5.19	5	1	5
10	R:R:W109	7.575	4	1	7
11	R:R:Q120	7.44	5	1	4
12	R:R:F121	8.0925	4	4	6
13	R:R:E124	9.7025	4	1	4
14	R:R:Y128	13.275	4	1	6
15	R:R:I134	5.034	5	1	8
16	R:R:Y142	8.356	5	0	8
17	R:R:W168	6.345	4	0	9
18	R:R:F220	9.9375	4	1	6
19	R:R:F221	7.435	4	0	8
20	R:R:P224	4.465	4	1	9
21	R:R:L231	6.6375	4	0	7
22	R:R:Y232	7.03	5	0	9
23	R:R:F272	8.1925	4	1	9
24	R:R:W276	8.05333	6	1	8
25	R:R:F279	9.222	5	1	6
26	R:R:R283	12.1325	4	1	6
27	R:R:L285	4.164	5	0	4
28	R:R:F286	6.1325	4	0	4
29	R:R:F309	8.05333	6	1	5
30	R:R:F312	7.50167	6	1	7
31	R:R:Y313	12.7075	4	1	7
32	R:R:N319	5.2525	4	1	9
33	R:R:Y330	8.0675	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F309	38.9166	7.63	Yes	Yes	1	0	5
2	R:R:F309	R:R:L100	31.8286	3.65	Yes	No	0	5	7
3	R:R:L100	R:R:T47	29.6589	7.37	No	No	0	7	6
4	L:L:?1	R:R:F279	59.0302	4.45	Yes	Yes	1	0	6
5	R:R:F279	R:R:W276	69.3691	10.02	Yes	Yes	1	6	8
6	R:R:F272	R:R:W276	100	18.04	Yes	Yes	1	9	8
7	R:R:F272	R:R:I134	98.1579	5.02	Yes	Yes	1	9	8
8	R:R:I134	R:R:L228	48.815	4.28	Yes	No	0	8	8
9	R:R:L228	R:R:S138	48.0105	4.5	No	No	0	8	9
10	R:R:S138	R:R:Y232	23.6012	6.36	No	Yes	0	9	9
11	R:R:V268	R:R:Y232	29.2985	3.79	No	Yes	0	8	9
12	R:R:L322	R:R:V268	26.9031	2.98	No	No	0	8	8
13	R:R:I318	R:R:L322	12.6106	4.28	No	No	0	7	8
14	L:L:?1	R:R:F312	49.6669	5.72	Yes	Yes	1	0	7
15	R:R:F312	R:R:W276	60.9159	4.01	Yes	Yes	1	7	8
16	R:R:I134	R:R:Y323	67.7891	7.25	Yes	No	0	8	9
17	R:R:R141	R:R:Y323	25.618	6.17	No	No	0	9	9
18	R:R:R141	R:R:Y232	24.9445	8.23	No	Yes	0	9	9
19	R:R:F279	R:R:H280	30.4671	11.31	Yes	No	0	6	7
20	R:R:F221	R:R:H280	28.8907	9.05	Yes	No	0	8	7
21	R:R:F221	R:R:V225	17.8383	7.87	Yes	No	0	8	6
22	R:R:T229	R:R:V225	17.1612	1.59	No	No	0	5	6
23	R:R:T229	R:R:V269	17.1757	1.59	No	No	0	5	8
24	R:R:V269	R:R:Y232	17.3031	5.05	No	Yes	0	8	9
25	R:R:M96	R:R:Y313	13.6336	16.76	No	Yes	0	7	7
26	R:R:F54	R:R:M96	12.2538	12.44	Yes	No	0	7	7
27	R:R:F309	R:R:Y313	17.8092	12.38	Yes	Yes	1	5	7
28	R:R:F312	R:R:Y313	18.996	11.35	Yes	Yes	1	7	7
29	R:R:S315	R:R:W276	24.3584	8.65	No	Yes	1	9	8
30	R:R:N319	R:R:S315	24.504	4.47	Yes	No	1	9	9
31	R:R:D89	R:R:N319	22.5454	8.08	Yes	Yes	0	9	9
32	R:R:D89	R:R:N61	10.6302	8.08	Yes	No	0	9	9
33	R:R:L82	R:R:Y323	65.5503	5.86	No	No	0	8	9
34	R:R:L82	R:R:N324	18.0604	6.87	No	No	0	8	7
35	R:R:N324	R:R:Y330	14.8385	20.93	No	Yes	3	7	8
36	L:L:?1	R:R:Q120	29.5424	7.64	Yes	Yes	1	0	4
37	R:R:F119	R:R:Q120	13.4697	10.54	No	Yes	0	4	4
38	R:R:C95	R:R:F119	10.2625	5.59	No	No	0	6	4
39	R:R:L137	R:R:L82	48.6403	5.54	No	No	0	8	8
40	R:R:L137	R:R:Y81	47.1841	8.21	No	Yes	0	8	8
41	R:R:E140	R:R:Y81	24.8098	8.98	No	Yes	0	9	8
42	R:R:E140	R:R:T78	11.4566	5.64	No	No	0	9	8
43	R:R:S327	R:R:Y330	11.6167	2.54	No	Yes	0	8	8
44	R:R:E140	R:R:T77	12.5305	9.88	No	Yes	0	9	7
45	R:R:V160	R:R:Y81	15.4865	6.31	No	Yes	0	7	8
46	R:R:T77	R:R:V160	12.5887	7.93	Yes	No	0	7	7
47	R:R:K157	R:R:T77	19.1052	9.01	No	Yes	0	3	7
48	L:L:?1	R:R:R102	36.0734	10.15	Yes	Yes	1	0	5
49	R:R:R102	R:R:W109	18.9523	4	Yes	Yes	1	5	7
50	R:R:C116	R:R:W109	12.9309	5.22	No	Yes	1	9	7
51	R:R:C116	R:R:K117	22.5199	6.47	No	No	0	9	7
52	R:R:F179	R:R:K117	12.8072	4.96	No	No	0	5	7
53	R:R:F121	R:R:F179	11.6859	15	Yes	No	0	6	5
54	R:R:F172	R:R:W168	10.2625	4.01	No	Yes	0	4	9
55	R:R:S84	R:R:W168	12.6361	6.18	No	Yes	0	9	9
56	R:R:C198	R:R:Q120	14.1068	4.58	No	Yes	1	9	4
57	R:R:C116	R:R:C198	12.6142	5.46	No	No	1	9	9
58	R:R:I134	R:R:M85	18.1222	4.37	Yes	Yes	1	8	9
59	R:R:M85	R:R:T130	22.4617	6.02	Yes	No	0	9	9
60	R:R:S88	R:R:T130	28.0789	4.8	No	No	0	8	9
61	R:R:S88	R:R:W168	25.1192	7.41	No	Yes	0	8	9
62	R:R:L43	R:R:T47	24.7879	1.47	No	No	0	5	6
63	R:R:L43	R:R:W104	22.3415	1.14	No	No	0	5	4
64	R:R:R107	R:R:W104	17.4269	7	No	No	0	4	4
65	R:R:E197	R:R:R102	16.8881	4.65	No	Yes	0	4	5
66	R:R:P108	R:R:R107	14.9587	1.44	No	No	0	4	4
67	R:R:D113	R:R:K117	10.3498	9.68	No	No	0	4	7
68	L:L:?1	R:R:E124	14.1651	6.92	Yes	Yes	1	0	4
69	R:R:E124	R:R:Y128	14.3798	14.59	Yes	Yes	1	4	6
70	R:R:F220	R:R:Y128	16.3421	25.79	Yes	Yes	1	6	6
71	R:R:L231	R:R:S138	45.3821	4.5	Yes	No	0	7	9
72	R:R:L231	R:R:Y142	34.7337	17.58	Yes	Yes	0	7	8
73	R:R:I235	R:R:Y142	19.4801	3.63	No	Yes	0	8	8
74	R:R:G158	R:R:K157	16.1418	3.49	No	No	0	4	3
75	R:R:G158	R:R:T156	12.9273	1.82	No	No	0	4	7
76	R:R:E197	R:R:R199	13.7428	4.65	No	No	0	4	3
77	R:R:E185	R:R:R199	12.0499	9.3	No	No	0	1	3
78	R:R:E185	R:R:T201	10.3498	4.23	No	No	0	1	3
79	R:R:N196	R:R:P108	10.0004	1.63	No	No	0	4	4
80	L:L:?1	R:R:L210	16.6297	4.34	Yes	No	0	0	3
81	R:R:L210	R:R:S287	13.7865	4.5	No	No	0	3	4
82	R:R:S287	R:R:T211	12.0245	4.8	No	No	0	4	4
83	R:R:T211	R:R:W215	10.3608	6.06	No	No	0	4	4
84	R:R:F221	R:R:L277	26.7174	8.53	Yes	No	0	8	6
85	R:R:L322	R:R:V267	12.3011	1.49	No	No	0	8	6
86	R:R:L277	R:R:V281	18.8685	2.98	No	No	0	6	7
87	R:R:L285	R:R:V281	17.7291	2.98	Yes	No	0	4	7
88	R:R:I297	R:R:L285	14.2816	4.28	No	Yes	0	1	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D99	7.79	1	Yes	No	0	6	0	1
L:L:?1	R:R:R102	10.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Q120	7.64	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S123	6.27	1	Yes	No	0	6	0	1
L:L:?1	R:R:E124	6.92	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L210	4.34	1	Yes	No	0	3	0	1
L:L:?1	R:R:F279	4.45	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R283	18.39	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F286	7.63	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F309	7.63	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F312	5.72	1	Yes	Yes	0	7	0	1
R:R:C50	R:R:F309	4.19	0	No	Yes	6	5	2	1
R:R:F312	R:R:I92	6.28	1	Yes	No	7	7	1	2
R:R:D99	R:R:F309	11.94	1	No	Yes	6	5	1	1
R:R:D99	R:R:Y313	10.34	1	No	Yes	6	7	1	2
R:R:R102	R:R:W109	4	1	Yes	Yes	5	7	1	2
R:R:Q120	R:R:R102	5.84	1	Yes	Yes	4	5	1	1
R:R:E197	R:R:R102	4.65	0	No	Yes	4	5	2	1
R:R:F309	R:R:L103	8.53	1	Yes	No	5	4	1	2
R:R:C198	R:R:W109	13.06	1	No	Yes	9	7	2	2
R:R:F119	R:R:Q120	10.54	0	No	Yes	4	4	2	1
R:R:Q120	R:R:V182	8.6	1	Yes	No	4	4	1	2
R:R:C198	R:R:Q120	4.58	1	No	Yes	9	4	2	1
R:R:E124	R:R:Y128	14.59	1	Yes	Yes	4	6	1	2
R:R:E124	R:R:I178	6.83	1	Yes	No	4	4	1	2
R:R:E124	R:R:R283	10.47	1	Yes	Yes	4	6	1	1
R:R:F312	R:R:T127	9.08	1	Yes	No	7	7	1	2
R:R:S217	R:R:Y128	5.09	0	No	Yes	6	6	2	2
R:R:L181	R:R:M213	5.65	0	No	No	4	5	2	1
R:R:L210	R:R:P200	4.93	0	No	No	3	4	1	2
R:R:F286	R:R:P200	5.78	0	Yes	No	4	4	1	2
R:R:L210	R:R:S287	4.5	0	No	No	3	4	1	2
R:R:H280	R:R:S217	5.58	0	No	No	7	6	2	2
R:R:R283	R:R:S217	7.91	1	Yes	No	6	6	1	2
R:R:F279	R:R:W276	10.02	1	Yes	Yes	6	8	1	2
R:R:F312	R:R:W276	4.01	1	Yes	Yes	7	8	1	2
R:R:F279	R:R:H280	11.31	1	Yes	No	6	7	1	2
R:R:F279	R:R:R283	11.76	1	Yes	Yes	6	6	1	1
R:R:F279	R:R:F312	8.57	1	Yes	Yes	6	7	1	1
R:R:F286	R:R:F290	7.5	0	Yes	No	4	1	1	2
R:R:F309	R:R:Y313	12.38	1	Yes	Yes	5	7	1	2
R:R:F312	R:R:Y313	11.35	1	Yes	Yes	7	7	1	2
R:R:F309	R:R:L100	3.65	1	Yes	No	5	7	1	2
R:R:F286	R:R:N305	3.62	0	Yes	No	4	4	1	2
L:L:?1	R:R:M213	2.95	1	Yes	No	0	5	0	1
R:R:M213	R:R:V212	1.52	0	No	No	5	6	1	2
R:R:R102	R:R:V101	1.31	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9V2N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.68
Number of Linked Nodes	259
Number of Links	284
Number of Hubs	33
Number of Links mediated by Hubs	125
Number of Communities	4
Number of Nodes involved in Communities	34
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	67559
Length Of Smallest Path	3
Average Path Length	12.9535
Length of Longest Path	28
Minimum Path Strength	1.285
Average Path Strength	6.69003
Maximum Path Strength	21.345
Minimum Path Correlation	0.7
Average Path Correlation	0.915401
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	44.4644
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.5693
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1E
Name	(R)-tacrine(10)-hupyridone
Synonyms	(R)-N-9 -(1 ,2 ,3 ,4 -TETRAHYDROACRIDINYL)-N'-5 -[5 ,6 ,7 ,8 -TETRAHYDRO-2'(1'H)-QUINOLINONYL]-1,10-DIAMINODECANE; (R)-TACRINE(10)-HUPYRIDONE
Identifier
Formula	C32 H44 N4 O
Molecular Weight	500.718
SMILES
PubChem	5287575
Formal Charge	0
Total Atoms	81
Total Chiral Atoms	1
Total Bonds	85
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92847
Sequence	>9V2N_nogp_Chain_R A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F R E L R T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y R P W N F G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F P L R A K V V V T K G R V K L V I F V I W A V A F C S A G P I F V L V G V E H D T N E C R P T E F A V R S G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E P G S L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K Y R V A V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KO5	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 57400002	-	-	3.3	2020-08-12	doi.org/10.1038/s41467-020-17554-1
	7F9Y	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Y (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-		2.9	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-		3.2	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7NA7	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-	Gi1/β1/γ2	2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA7 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-		2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA8	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-	Gi1/β1/γ2	2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA8 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-		2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7F83	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PF-05190457	-	-	2.94	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	7W2Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-	Go/β1/γ2	2.8	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	7W2Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-		2.8	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	8JSR	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	8JSR (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	9UY3	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.52	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9UY3 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.52	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-		2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7

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