Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F38 5.41414
2R:R:I58 3.974506
3R:R:F71 4.4475445
4R:R:L74 5.3825448
5R:R:T77 5.9675407
6R:R:Y81 6.592508
7R:R:S88 5.1975428
8R:R:D89 6.146519
9R:R:F93 3.805406
10R:R:D99 7.018516
11R:R:R102 11.3425415
12R:R:W109 6.50667617
13R:R:L115 3.2325415
14R:R:F119 6.735404
15R:R:Q120 9.288514
16R:R:F121 7.43426
17R:R:E124 11.2975414
18R:R:I134 5.855418
19R:R:Y142 9.1675408
20R:R:W168 6.845429
21R:R:V184 5.6325415
22R:R:C198 7.015419
23R:R:F220 7.2825406
24R:R:P224 5.2875409
25R:R:L231 5.72407
26R:R:Y232 7.948509
27R:R:I235 2.97458
28R:R:L239 4.4125458
29R:R:F272 7.12419
30R:R:W276 7.335618
31R:R:F279 11.425416
32R:R:H280 6.965407
33R:R:R283 14.59416
34R:R:F286 8.91414
35R:R:L306 4.37404
36R:R:F312 8.456517
37R:R:Y313 11.405417
38R:R:N319 5.71419
39R:R:L322 3.075408
40R:R:Y323 4.82571719
41R:R:Y330 8.4475438
42L:L:?1 9.408331210
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L306 R:R:L42 15.43512.77YesNo043
2R:R:F38 R:R:L43 19.41094.87YesNo045
3R:R:L43 R:R:W104 16.66319.11NoNo054
4R:R:F38 R:R:Q302 29.54367.03YesNo143
5L:L:?1 R:R:Q302 34.35666.25YesNo103
6R:R:D99 R:R:Y313 37.16464.6YesYes167
7R:R:M96 R:R:Y313 17.448813.17NoYes077
8R:R:F54 R:R:M96 15.70563.73NoNo077
9R:R:L103 R:R:L306 14.78254.15NoYes044
10R:R:F309 R:R:L103 16.44847.31NoNo054
11R:R:F309 R:R:Y313 12.880515.47NoYes157
12R:R:F54 R:R:I58 14.77827.54NoYes076
13R:R:F93 R:R:I58 13.8683.77YesYes066
14L:L:?1 R:R:R283 90.708921.57YesYes106
15R:R:F279 R:R:R283 88.854117.1YesYes166
16R:R:F279 R:R:W276 91.44310.02YesYes168
17R:R:F272 R:R:W276 10014.03YesYes198
18R:R:F272 R:R:I134 68.03495.02YesYes198
19R:R:I134 R:R:N319 45.23645.66YesYes189
20R:R:D89 R:R:N319 66.48498.08YesYes199
21R:R:I134 R:R:Y323 23.12488.46YesYes189
22R:R:L82 R:R:Y323 12.71745.86NoYes089
23R:R:L82 R:R:N324 10.96139.61NoNo087
24L:L:?1 R:R:R102 61.281214.59YesYes105
25R:R:C198 R:R:R102 82.46538.36YesYes195
26R:R:C198 R:R:W109 73.96427.84YesYes197
27R:R:V184 R:R:W109 79.97087.36YesYes157
28R:R:D113 R:R:V184 77.48065.84NoYes045
29R:R:D113 R:R:K117 73.60789.68NoNo047
30R:R:F179 R:R:K117 70.62387.44NoNo057
31R:R:F121 R:R:F179 65.922513.93YesNo065
32R:R:F121 R:R:F172 55.11147.5YesNo264
33R:R:F172 R:R:W168 56.1596.01NoYes249
34R:R:S84 R:R:W168 97.34236.18NoYes099
35R:R:I164 R:R:S84 95.54334.64NoNo079
36R:R:I164 R:R:Y81 93.73584.84NoYes078
37R:R:E140 R:R:Y81 41.94328.98NoYes098
38R:R:E140 R:R:T77 34.67439.88NoYes097
39R:R:T76 R:R:T77 61.75783.14NoYes077
40R:R:N79 R:R:T76 53.63454.39NoNo087
41L:L:?1 R:R:Q120 65.97839.73YesYes104
42R:R:C198 R:R:Q120 62.78824.58YesYes194
43R:R:C116 R:R:C198 69.90257.28NoYes199
44R:R:C116 R:R:V184 67.91033.42NoYes195
45R:R:D89 R:R:T130 67.735.78YesNo099
46R:R:S88 R:R:T130 67.03024.8YesNo089
47R:R:S88 R:R:W168 61.66337.41YesYes289
48R:R:V160 R:R:Y81 40.8147.57NoYes078
49R:R:T77 R:R:V160 34.91486.35YesNo077
50R:R:N79 R:R:V68 20.79774.43NoNo087
51R:R:L74 R:R:N79 29.05844.12YesNo088
52R:R:F71 R:R:L74 12.48983.65YesYes458
53R:R:R75 R:R:V68 12.50271.31NoNo077
54R:R:A316 R:R:F93 14.73534.16NoYes096
55R:R:F312 R:R:Y313 40.049812.38YesYes177
56R:R:D99 R:R:F119 18.17878.36YesYes064
57R:R:F119 R:R:L98 17.08818.53YesNo045
58R:R:P200 R:R:R199 26.78722.88NoNo043
59L:L:?1 R:R:P200 28.84384.29YesNo104
60R:R:N196 R:R:V184 75.6735.91NoYes045
61R:R:N110 R:R:N196 70.32332.72NoNo034
62R:R:N110 R:R:P108 10.90984.89NoNo034
63R:R:N110 R:R:W193 54.222710.17NoNo034
64R:R:E124 R:R:Y128 14.675216.83YesNo046
65R:R:R283 R:R:S217 23.62299.22YesNo066
66R:R:F220 R:R:Y128 24.691916.5YesNo066
67R:R:V131 R:R:W276 25.00544.9NoYes088
68R:R:P224 R:R:V131 23.79465.3YesNo098
69R:R:F272 R:R:P224 35.10375.78YesYes099
70R:R:F220 R:R:L132 15.49536.09YesNo066
71R:R:P224 R:R:T135 52.1793.5YesNo097
72R:R:F272 R:R:L228 20.02063.65YesNo198
73R:R:L228 R:R:S138 19.56126.01NoNo089
74R:R:S138 R:R:Y232 18.14015.09NoYes099
75R:R:L231 R:R:Y142 32.029515.24YesYes078
76R:R:C227 R:R:L231 46.49443.17NoYes067
77R:R:C227 R:R:T135 49.3413.38NoNo067
78R:R:F143 R:R:F147 11.8635.36NoNo056
79R:R:F147 R:R:Y142 17.53045.16NoYes068
80R:R:L265 R:R:Y232 28.633417.58NoYes089
81R:R:I235 R:R:L265 26.46952.85YesNo088
82R:R:F121 R:R:G176 15.0233.01YesNo064
83R:R:G176 R:R:P177 12.03474.06NoNo047
84L:L:?1 R:R:F286 20.570215.9YesYes104
85R:R:E185 R:R:R199 18.839911.63NoNo013
86R:R:E185 R:R:T201 13.49454.23NoNo013
87R:R:D191 R:R:W193 48.83868.93NoNo064
88R:R:D191 R:R:P192 16.3546.44NoNo061
89R:R:H186 R:R:P192 10.90989.15NoNo021
90R:R:D194 R:R:T195 21.78957.23NoNo053
91R:R:D191 R:R:D194 27.21656.65NoNo065
92R:R:T190 R:R:T195 10.90127.85NoNo633
93R:R:F286 R:R:F290 15.81736.43YesNo041
94R:R:H280 R:R:S217 23.84185.58YesNo076
95R:R:H280 R:R:S218 20.60454.18YesNo074
96R:R:F279 R:R:H280 38.68026.79YesYes067
97R:R:S218 R:R:W215 18.05853.71NoNo044
98R:R:W215 R:R:Y284 10.36883.86NoNo045
99R:R:F221 R:R:H280 26.997611.31NoYes087
100R:R:F221 R:R:F222 11.36495.36NoNo084
101R:R:F221 R:R:L277 15.38366.09NoNo086
102L:L:?1 R:R:N305 19.647112.19YesNo004
103R:R:G282 R:R:N305 14.67955.09NoNo044
104R:R:V268 R:R:Y323 11.00853.79NoYes089
105R:R:I235 R:R:L239 15.62412.85YesYes588
106R:R:H258 R:R:L239 11.22329NoYes068
107R:R:F290 R:R:S289 10.63933.96NoNo012
108R:R:R141 R:R:Y323 17.26855.14NoYes099
109R:R:L277 R:R:P278 13.42583.28NoNo069
110R:R:L311 R:R:P278 10.08113.28NoNo079
111R:R:A316 R:R:D89 15.05734.63NoYes099
112R:R:F312 R:R:W276 36.224.01YesYes178
113R:R:D99 R:R:R102 22.158811.91YesYes165
114R:R:L98 R:R:W109 12.08194.56NoYes157
115R:R:N319 R:R:Y323 24.09943.49YesYes199
116R:R:R141 R:R:Y232 10.02968.23NoYes099
117R:R:S217 R:R:Y128 13.43875.09NoNo066
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:L37 3.65 1 Yes No 4 5 2 2
R:R:L37 R:R:Q302 6.65 1 No No 5 3 2 1
R:R:F38 R:R:Q302 7.03 1 Yes No 4 3 2 1
R:R:D99 R:R:R102 11.91 1 Yes Yes 6 5 1 1
R:R:D99 R:R:F119 8.36 1 Yes Yes 6 4 1 2
R:R:D99 R:R:F309 5.97 1 Yes No 6 5 1 2
R:R:D99 R:R:Y313 4.6 1 Yes Yes 6 7 1 2
L:L:?1 R:R:D99 4.25 1 Yes Yes 0 6 0 1
R:R:Q120 R:R:R102 10.51 1 Yes Yes 4 5 1 1
R:R:C198 R:R:R102 8.36 1 Yes Yes 9 5 2 1
L:L:?1 R:R:R102 14.59 1 Yes Yes 0 5 0 1
R:R:F119 R:R:Q120 5.86 0 Yes Yes 4 4 2 1
R:R:Q120 R:R:V182 15.76 1 Yes No 4 4 1 2
R:R:C198 R:R:Q120 4.58 1 Yes Yes 9 4 2 1
L:L:?1 R:R:Q120 9.73 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S123 6.27 1 Yes No 0 6 0 1
R:R:E124 R:R:Y128 16.83 1 Yes No 4 6 1 2
R:R:E124 R:R:I178 8.2 1 Yes No 4 4 1 2
R:R:E124 R:R:R283 10.47 1 Yes Yes 4 6 1 1
L:L:?1 R:R:E124 9.69 1 Yes Yes 0 4 0 1
R:R:S217 R:R:Y128 5.09 0 No No 6 6 2 2
R:R:L181 R:R:L209 4.15 0 No No 4 4 1 2
R:R:L181 R:R:L210 4.15 0 No No 4 3 1 2
L:L:?1 R:R:L181 5.06 1 Yes No 0 4 0 1
R:R:F286 R:R:P200 7.22 1 Yes No 4 4 1 1
L:L:?1 R:R:P200 4.29 1 Yes No 0 4 0 1
R:R:F286 R:R:L210 6.09 1 Yes No 4 3 1 2
R:R:R283 R:R:S217 9.22 1 Yes No 6 6 1 2
R:R:F279 R:R:R283 17.1 1 Yes Yes 6 6 2 1
R:R:G282 R:R:N305 5.09 0 No No 4 4 2 1
L:L:?1 R:R:R283 21.57 1 Yes Yes 0 6 0 1
R:R:F286 R:R:F290 6.43 1 Yes No 4 1 1 2
L:L:?1 R:R:F286 15.9 1 Yes Yes 0 4 0 1
L:L:?1 R:R:Q302 6.25 1 Yes No 0 3 0 1
L:L:?1 R:R:N305 12.19 1 Yes No 0 4 0 1
R:R:F309 R:R:Y313 15.47 1 No Yes 5 7 2 2
R:R:S287 R:R:V214 3.23 0 No No 4 5 2 1
L:L:?1 R:R:V214 3.11 1 Yes No 0 5 0 1
R:R:N305 R:R:S308 2.98 0 No No 4 7 1 2
R:R:P200 R:R:R199 2.88 1 No No 4 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9UY3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.42
Number of Linked Nodes 274
Number of Links 308
Number of Hubs 42
Number of Links mediated by Hubs 153
Number of Communities 6
Number of Nodes involved in Communities 49
Number of Links involved in Communities 66
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 83186
Length Of Smallest Path 3
Average Path Length 14.6578
Length of Longest Path 27
Minimum Path Strength 1.3
Average Path Strength 7.25776
Maximum Path Strength 19.335
Minimum Path Correlation 0.7
Average Path Correlation 0.919729
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 43.0752
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.6939
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeA1E
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeA1E
Name(R)-tacrine(10)-hupyridone
Synonyms(R)-N-9 -(1 ,2 ,3 ,4 -TETRAHYDROACRIDINYL)-N'-5 -[5 ,6 ,7 ,8 -TETRAHYDRO-2'(1'H)-QUINOLINONYL]-1,10-DIAMINODECANE; (R)-TACRINE(10)-HUPYRIDONE
Identifier
FormulaC32 H44 N4 O
Molecular Weight500.718
SMILES
PubChem5287575
Formal Charge0
Total Atoms81
Total Chiral Atoms1
Total Bonds85
Total Aromatic Bonds17

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ92847
Sequence
>9UY3_nogp_Chain_R
LFPAPLLAG VTATCVALF VVGIAGNLL TMLVVSRFR ELRTTTNLY 
LSSMAFSDL LIFLCMPLD LVRLWQYRP WNFGDLLCK LFQFVSESC 
TYATVLTIT ALSVERYFA ICFPLRAKV VVTKGRVKL VIFVIWAVA 
FCSAGPIFV LVGVEHENG TDPWDTNEC RPTEFAVRS GLLTVMVWV 
SSIFFFLPV FCLTVLYSL IGRKLWRNH KQTVKMLAV VVFAFILCW 
LPFHVGRYL FSKSFEPGS LEIAQISQY CNLVSFVLF YLSAAINPI 
LYNIMSKKY RVAV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6KO5APeptideGhrelinGhrelinHomo sapiensPubChem 57400002--3.32020-08-12doi.org/10.1038/s41467-020-17554-1
7F9YAPeptideGhrelinGhrelinHomo sapiensGhrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ22.92021-08-18doi.org/10.1038/s41467-021-25364-2
7F9Y (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-28-2.92021-08-18doi.org/10.1038/s41467-021-25364-2
7F9ZAPeptideGhrelinGhrelinHomo sapiensGHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ23.22021-08-18doi.org/10.1038/s41467-021-25364-2
7F9Z (No Gprot) APeptideGhrelinGhrelinHomo sapiensGHRP-6-3.22021-08-18doi.org/10.1038/s41467-021-25364-2
7NA7APeptideGhrelinGhrelinHomo sapiensGhrelin-27-Gi1/β1/γ22.72021-12-15doi.org/10.1038/s41467-021-26735-5
7NA7 (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-27-2.72021-12-15doi.org/10.1038/s41467-021-26735-5
7NA8APeptideGhrelinGhrelinHomo sapiensPubChem 178024-Gi1/β1/γ22.72021-12-15doi.org/10.1038/s41467-021-26735-5
7NA8 (No Gprot) APeptideGhrelinGhrelinHomo sapiensPubChem 178024-2.72021-12-15doi.org/10.1038/s41467-021-26735-5
7F83APeptideGhrelinGhrelinHomo sapiensPF-05190457--2.942022-01-19doi.org/10.1038/s41467-022-27975-9
7W2ZAPeptideGhrelinGhrelinHomo sapiensGhrelin-Go/β1/γ22.82022-01-19doi.org/10.1038/s41467-022-27975-9
7W2Z (No Gprot) APeptideGhrelinGhrelinHomo sapiensGhrelin-2.82022-01-19doi.org/10.1038/s41467-022-27975-9
8JSRAPeptideGhrelinGhrelinHomo sapiensAnamorelin-chim(NtGi1-Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1038/s41594-024-01481-6
8JSR (No Gprot) APeptideGhrelinGhrelinHomo sapiensAnamorelin-2.92025-01-22doi.org/10.1038/s41594-024-01481-6
9UY3APeptideGhrelinGhrelinHomo sapiensAnamorelin-chim(NtGi1-Gs-CtGq)/β1/γ22.522025-07-02doi.org/10.1038/s41401-025-01606-7
9UY3 (No Gprot) APeptideGhrelinGhrelinHomo sapiensAnamorelin-2.522025-07-02doi.org/10.1038/s41401-025-01606-7
9V2NAPeptideGhrelinGhrelinHomo sapiensMacimorelin-chim(NtGi1-Gs-CtGq)/β1/γ22.632025-07-02doi.org/10.1038/s41401-025-01606-7
9V2N (No Gprot) APeptideGhrelinGhrelinHomo sapiensMacimorelin-2.632025-07-02doi.org/10.1038/s41401-025-01606-7




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