psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D99	3.94	Yes	Yes	1	0	6
2	L:L:?1	R:R:R102	17.65	Yes	No	0	0	5
3	L:L:?1	R:R:L103	6.43	Yes	No	0	0	4
4	L:L:?1	R:R:Q120	17.01	Yes	Yes	1	0	4
5	L:L:?1	R:R:S123	3.49	Yes	No	0	0	6
6	L:L:?1	R:R:E124	7.7	Yes	No	1	0	4
7	L:L:?1	R:R:M213	4.11	Yes	Yes	0	0	5
8	L:L:?1	R:R:R283	19.06	Yes	Yes	1	0	6
9	L:L:?1	R:R:F286	16.28	Yes	Yes	1	0	4
10	L:L:?1	R:R:Q302	3.09	Yes	No	0	0	3
11	L:L:?1	R:R:N305	11.97	Yes	Yes	1	0	4
12	R:R:P39	R:R:Q105	3.16	No	No	0	4	4
13	R:R:P39	R:R:Q302	4.74	No	No	0	4	3
14	R:R:L42	R:R:V46	2.98	No	No	0	3	4
15	R:R:L43	R:R:V46	4.47	Yes	No	0	5	4
16	R:R:L43	R:R:T47	5.9	Yes	No	0	5	6
17	R:R:L103	R:R:L43	5.54	No	Yes	0	4	5
18	R:R:L43	R:R:W104	10.25	Yes	No	0	5	4
19	R:R:C50	R:R:M96	3.24	Yes	Yes	1	6	7
20	R:R:C50	R:R:L100	3.17	Yes	No	1	6	7
21	R:R:F54	R:R:I58	10.05	No	No	1	7	6
22	R:R:F54	R:R:F93	7.5	No	Yes	1	7	6
23	R:R:F93	R:R:G57	4.52	Yes	No	0	6	8
24	R:R:F93	R:R:I58	5.02	Yes	No	1	6	6
25	R:R:G60	R:R:P320	4.06	No	Yes	0	8	9
26	R:R:A86	R:R:N61	4.69	No	No	0	9	9
27	R:R:D89	R:R:N61	9.42	Yes	No	0	9	9
28	R:R:N61	R:R:P320	11.4	No	Yes	0	9	9
29	R:R:L63	R:R:V67	4.47	No	No	0	6	8
30	R:R:L63	R:R:V334	2.98	No	Yes	0	6	6
31	R:R:L337	R:R:L66	4.15	Yes	No	0	5	3
32	R:R:L337	R:R:V67	2.98	Yes	No	0	5	8
33	R:R:N79	R:R:V68	4.43	No	No	0	8	7
34	R:R:F71	R:R:R70	10.69	Yes	No	2	5	5
35	R:R:L337	R:R:R70	6.07	Yes	No	2	5	5
36	R:R:E73	R:R:F71	5.83	No	Yes	0	6	5
37	R:R:F71	R:R:L74	3.65	Yes	No	0	5	8
38	R:R:A333	R:R:F71	8.32	No	Yes	0	6	5
39	R:R:F71	R:R:R336	4.28	Yes	No	0	5	3
40	R:R:F71	R:R:L337	3.65	Yes	Yes	2	5	5
41	R:R:R72	R:R:R75	5.33	No	No	0	6	7
42	R:R:L74	R:R:N79	4.12	No	No	0	8	8
43	R:R:N79	R:R:T76	5.85	No	No	0	8	7
44	R:R:T77	R:R:V160	6.35	No	No	0	7	7
45	R:R:L80	R:R:S83	3	No	No	0	5	6
46	R:R:T133	R:R:Y81	3.75	No	Yes	0	8	8
47	R:R:A136	R:R:Y81	4	No	Yes	0	7	8
48	R:R:L137	R:R:Y81	5.86	No	Yes	0	8	8
49	R:R:E140	R:R:Y81	13.47	No	Yes	0	9	8
50	R:R:V160	R:R:Y81	8.83	No	Yes	0	7	8
51	R:R:V163	R:R:Y81	6.31	No	Yes	0	6	8
52	R:R:L82	R:R:Y323	5.86	No	Yes	0	8	9
53	R:R:L82	R:R:N324	6.87	No	No	0	8	7
54	R:R:S84	R:R:T133	3.2	No	No	0	9	8
55	R:R:I164	R:R:S84	3.1	No	No	0	7	9
56	R:R:S84	R:R:W168	6.18	No	Yes	0	9	9
57	R:R:M85	R:R:T133	6.02	No	No	0	9	8
58	R:R:M85	R:R:N319	7.01	No	No	0	9	9
59	R:R:F87	R:R:L91	9.74	No	Yes	0	6	7
60	R:R:A129	R:R:S88	3.42	No	No	3	6	8
61	R:R:S88	R:R:W168	7.41	No	Yes	3	8	9
62	R:R:D89	R:R:K130	9.68	Yes	Yes	1	9	9
63	R:R:A316	R:R:D89	6.18	No	Yes	0	9	9
64	R:R:D89	R:R:N319	5.39	Yes	No	1	9	9
65	R:R:L91	R:R:V122	2.98	Yes	No	0	7	5
66	R:R:C126	R:R:L91	4.76	No	Yes	0	8	7
67	R:R:C126	R:R:I92	4.91	No	No	0	8	7
68	R:R:F312	R:R:I92	6.28	Yes	No	0	7	7
69	R:R:F93	R:R:Y313	5.16	Yes	Yes	1	6	7
70	R:R:A316	R:R:F93	4.16	No	Yes	0	9	6
71	R:R:C95	R:R:V122	3.42	No	No	0	6	5
72	R:R:M96	R:R:P97	3.35	Yes	No	0	7	7
73	R:R:L100	R:R:M96	7.07	No	Yes	1	7	7
74	R:R:M96	R:R:Y313	22.75	Yes	Yes	1	7	7
75	R:R:F119	R:R:L98	9.74	No	No	0	4	5
76	R:R:D99	R:R:F119	10.75	Yes	No	0	6	4
77	R:R:D99	R:R:F309	10.75	Yes	No	1	6	5
78	R:R:D99	R:R:Y313	3.45	Yes	Yes	1	6	7
79	R:R:R102	R:R:W109	4	No	No	0	5	7
80	R:R:F309	R:R:L103	9.74	No	No	0	5	4
81	R:R:P108	R:R:W109	8.11	No	No	0	4	7
82	R:R:E197	R:R:W109	4.36	No	No	0	4	7
83	R:R:N110	R:R:W193	6.78	No	No	0	3	4
84	R:R:N110	R:R:N196	5.45	No	No	0	3	4
85	R:R:F111	R:R:L115	9.74	No	No	0	6	5
86	R:R:C116	R:R:F111	4.19	Yes	No	4	9	6
87	R:R:C198	R:R:F111	5.59	No	No	4	9	6
88	R:R:G112	R:R:L115	3.42	No	No	0	8	5
89	R:R:K117	R:R:L114	5.64	No	No	0	7	4
90	R:R:C116	R:R:C198	5.46	Yes	No	4	9	9
91	R:R:F119	R:R:Q120	9.37	No	Yes	0	4	4
92	R:R:I178	R:R:Q120	4.12	Yes	Yes	1	4	4
93	R:R:Q120	R:R:V182	11.46	Yes	No	1	4	4
94	R:R:F121	R:R:F172	6.43	Yes	No	0	6	4
95	R:R:F121	R:R:I178	3.77	Yes	Yes	0	6	4
96	R:R:F121	R:R:F179	15	Yes	Yes	0	6	5
97	R:R:E124	R:R:Y128	17.96	No	No	0	4	6
98	R:R:E124	R:R:R283	13.96	No	Yes	1	4	6
99	R:R:F172	R:R:S125	5.28	No	No	0	4	5
100	R:R:T127	R:R:W276	3.64	No	Yes	1	7	8
101	R:R:F312	R:R:T127	6.49	Yes	No	1	7	7
102	R:R:S217	R:R:Y128	3.82	No	No	0	6	6
103	R:R:F220	R:R:Y128	28.88	Yes	No	0	6	6
104	R:R:A129	R:R:W168	7.78	No	Yes	3	6	9
105	R:R:K130	R:R:W276	9.28	Yes	Yes	1	9	8
106	R:R:K130	R:R:S315	4.59	Yes	No	1	9	9
107	R:R:K130	R:R:N319	4.2	Yes	No	1	9	9
108	R:R:F220	R:R:V131	3.93	Yes	No	0	6	8
109	R:R:P224	R:R:V131	3.53	Yes	No	0	9	8
110	R:R:V131	R:R:W276	3.68	No	Yes	0	8	8
111	R:R:I167	R:R:L132	5.71	No	No	0	7	6
112	R:R:L132	R:R:V170	2.98	No	No	0	6	4
113	R:R:F220	R:R:L132	6.09	Yes	No	0	6	6
114	R:R:I134	R:R:L228	4.28	No	No	0	8	8
115	R:R:F272	R:R:I134	5.02	Yes	No	0	9	8
116	R:R:I134	R:R:Y323	6.04	No	Yes	0	8	9
117	R:R:P224	R:R:T135	3.5	Yes	No	0	9	7
118	R:R:C227	R:R:T135	6.76	No	No	0	6	7
119	R:R:L228	R:R:S138	7.51	No	No	0	8	9
120	R:R:S138	R:R:Y232	8.9	No	Yes	0	9	9
121	R:R:F143	R:R:V139	6.55	No	No	0	5	7
122	R:R:L231	R:R:V139	2.98	No	No	0	7	7
123	R:R:R141	R:R:Y232	10.29	No	Yes	0	9	9
124	R:R:R141	R:R:Y323	8.23	No	Yes	0	9	9
125	R:R:C146	R:R:Y142	9.41	No	Yes	0	7	8
126	R:R:F147	R:R:Y142	6.19	No	Yes	0	6	8
127	R:R:L231	R:R:Y142	9.38	No	Yes	0	7	8
128	R:R:L234	R:R:Y142	7.03	No	Yes	0	5	8
129	R:R:I145	R:R:I235	7.36	No	No	0	9	8
130	R:R:C146	R:R:K238	4.85	No	No	0	7	5
131	R:R:F147	R:R:R150	5.34	No	No	0	6	5
132	R:R:R159	R:R:T156	3.88	No	No	0	5	7
133	R:R:L162	R:R:V166	2.98	No	No	0	3	4
134	R:R:I167	R:R:V163	3.07	No	No	0	7	6
135	R:R:F172	R:R:W168	5.01	No	Yes	0	4	9
136	R:R:F220	R:R:S174	5.28	Yes	No	0	6	5
137	R:R:G176	R:R:P177	4.06	No	No	0	4	7
138	R:R:M213	R:R:P177	6.71	Yes	No	0	5	7
139	R:R:I178	R:R:L181	4.28	Yes	No	1	4	4
140	R:R:I178	R:R:V182	4.61	Yes	No	1	4	4
141	R:R:L181	R:R:V182	2.98	No	No	1	4	4
142	R:R:L181	R:R:M213	5.65	No	Yes	0	4	5
143	R:R:E185	R:R:R199	13.96	No	Yes	5	1	3
144	R:R:E185	R:R:T201	4.23	No	No	0	1	3
145	R:R:E185	R:R:E202	7.61	No	No	5	1	6
146	R:R:H186	R:R:N196	3.83	No	No	0	2	4
147	R:R:E187	R:R:T195	7.06	No	No	0	3	3
148	R:R:D194	R:R:P192	6.44	No	No	0	5	1
149	R:R:D194	R:R:T195	7.23	No	No	0	5	3
150	R:R:E197	R:R:R199	5.82	No	Yes	0	4	3
151	R:R:E202	R:R:R199	19.77	No	Yes	5	6	3
152	R:R:L210	R:R:P200	9.85	No	No	0	3	4
153	R:R:F203	R:R:R206	3.21	No	No	0	6	1
154	R:R:A204	R:R:L209	4.73	No	No	0	4	4
155	R:R:F290	R:R:V205	6.55	No	No	0	1	4
156	R:R:E291	R:R:V205	4.28	No	No	0	1	4
157	R:R:G208	R:R:S207	3.71	No	No	0	2	3
158	R:R:L210	R:R:S287	4.5	No	No	0	3	4
159	R:R:M213	R:R:V216	6.09	Yes	No	0	5	5
160	R:R:S287	R:R:V214	3.23	No	No	0	4	5
161	R:R:H280	R:R:S217	5.58	No	No	0	7	6
162	R:R:R283	R:R:S217	3.95	Yes	No	0	6	6
163	R:R:F222	R:R:S218	7.93	No	No	0	4	4
164	R:R:F221	R:R:F222	5.36	Yes	No	0	8	4
165	R:R:F221	R:R:F272	4.29	Yes	Yes	1	8	9
166	R:R:F221	R:R:L277	7.31	Yes	No	0	8	6
167	R:R:F221	R:R:H280	10.18	Yes	No	0	8	7
168	R:R:F222	R:R:F226	3.22	No	No	0	4	3
169	R:R:L223	R:R:P224	6.57	No	Yes	0	5	9
170	R:R:F272	R:R:P224	5.78	Yes	Yes	0	9	9
171	R:R:C227	R:R:L228	4.76	No	No	0	6	8
172	R:R:L231	R:R:V230	2.98	No	No	0	7	4
173	R:R:L265	R:R:Y232	8.21	No	Yes	0	8	9
174	R:R:V268	R:R:Y232	3.79	No	Yes	0	8	9
175	R:R:V269	R:R:Y232	5.05	No	Yes	0	8	9
176	R:R:L234	R:R:R237	4.86	No	No	0	5	4
177	R:R:G236	R:R:I235	3.53	No	No	0	5	8
178	R:R:R237	R:R:R241	15.99	No	No	0	4	5
179	R:R:K238	R:R:R242	8.66	No	No	0	5	5
180	R:R:H258	R:R:L239	16.71	No	No	0	6	8
181	R:R:K259	R:R:W240	8.12	No	No	0	5	4
182	R:R:V262	R:R:W240	4.9	No	No	0	7	4
183	R:R:K259	R:R:R243	8.66	No	No	0	5	3
184	R:R:D255	R:R:N257	9.42	No	No	0	1	5
185	R:R:K259	R:R:Q256	4.07	No	No	0	5	4
186	R:R:K263	R:R:Q260	6.78	No	No	0	7	7
187	R:R:K263	R:R:V267	3.04	No	No	0	7	6
188	R:R:M264	R:R:M326	5.78	No	No	0	8	7
189	R:R:L322	R:R:V268	2.98	No	No	0	8	8
190	R:R:V268	R:R:Y323	5.05	No	Yes	0	8	9
191	R:R:I273	R:R:V269	3.07	No	No	0	6	8
192	R:R:F272	R:R:W276	13.03	Yes	Yes	1	9	8
193	R:R:C275	R:R:W276	3.92	No	Yes	1	9	8
194	R:R:C275	R:R:S315	3.44	No	No	1	9	9
195	R:R:F279	R:R:W276	6.01	Yes	Yes	1	6	8
196	R:R:F312	R:R:W276	4.01	Yes	Yes	1	7	8
197	R:R:S315	R:R:W276	6.18	No	Yes	1	9	8
198	R:R:L277	R:R:P278	3.28	No	No	0	6	9
199	R:R:L277	R:R:V281	2.98	No	No	0	6	7
200	R:R:L311	R:R:P278	3.28	No	No	0	7	9
201	R:R:F279	R:R:H280	4.53	Yes	No	0	6	7
202	R:R:F279	R:R:R283	12.83	Yes	Yes	1	6	6
203	R:R:F279	R:R:S308	3.96	Yes	No	0	6	7
204	R:R:F279	R:R:F312	7.5	Yes	Yes	1	6	7
205	R:R:G282	R:R:N305	5.09	No	Yes	0	4	4
206	R:R:K288	R:R:Y284	9.55	No	No	0	4	5
207	R:R:C304	R:R:L285	3.17	No	No	0	5	4
208	R:R:F286	R:R:F290	3.22	Yes	No	0	4	1
209	R:R:F286	R:R:N305	4.83	Yes	Yes	1	4	4
210	R:R:K288	R:R:S294	3.06	No	No	0	4	6
211	R:R:F290	R:R:S289	5.28	No	No	0	1	2
212	R:R:S289	R:R:S294	3.26	No	No	0	2	6
213	R:R:E291	R:R:P292	4.72	No	No	0	1	2
214	R:R:I297	R:R:S294	9.29	No	No	0	1	6
215	R:R:I300	R:R:Q299	5.49	No	No	0	2	1
216	R:R:Q299	R:R:Y303	3.38	No	No	0	1	1
217	R:R:N305	R:R:S308	5.96	Yes	No	0	4	7
218	R:R:L311	R:R:V307	2.98	No	No	0	7	5
219	R:R:F309	R:R:Y313	10.32	No	Yes	1	5	7
220	R:R:F312	R:R:Y313	11.35	Yes	Yes	1	7	7
221	R:R:N324	R:R:Y330	19.77	No	No	0	7	8
222	R:R:I325	R:R:M326	8.75	No	No	0	6	7
223	R:R:M326	R:R:R331	6.2	No	No	0	7	8
224	R:R:K328	R:R:V332	3.04	No	No	0	5	4
225	R:R:V334	R:R:Y330	8.83	Yes	No	0	6	8
226	R:R:F335	R:R:F340	6.43	No	No	0	3	4
227	R:R:G339	R:R:L338	3.42	No	No	0	5	7
228	R:R:L137	R:R:T78	2.95	No	No	0	8	8
229	R:R:L239	R:R:T261	2.95	No	No	0	8	8
230	R:R:I318	R:R:I321	2.94	No	No	0	7	6
231	R:R:P200	R:R:R199	2.88	No	Yes	0	4	3
232	R:R:I58	R:R:L90	2.85	No	No	0	6	7
233	R:R:E140	R:R:V155	2.85	No	No	0	9	7
234	R:R:I300	R:R:L285	2.85	No	No	0	2	4
235	R:R:I318	R:R:L314	2.85	No	No	0	7	5
236	R:R:L90	R:R:M65	2.83	No	No	0	7	7
237	R:R:L209	R:R:M213	2.83	No	Yes	0	4	5
238	R:R:K329	R:R:L74	2.82	No	No	0	6	8
239	R:R:K157	R:R:L80	2.82	No	No	0	3	5
240	R:R:E291	R:R:T211	2.82	No	No	0	1	4
241	R:R:L314	R:R:L53	2.77	No	No	0	5	7
242	R:R:L62	R:R:L66	2.77	No	No	0	3	3
243	R:R:L115	R:R:L98	2.77	No	No	0	5	5
244	R:R:A175	R:R:F121	2.77	No	Yes	0	7	6
245	R:R:E296	R:R:I297	2.73	No	No	0	2	1
246	R:R:F286	R:R:S301	2.64	Yes	No	0	4	4
247	R:R:R159	R:R:V154	2.62	No	No	0	5	4
248	R:R:F221	R:R:V225	2.62	Yes	Yes	1	8	6
249	R:R:F226	R:R:V225	2.62	No	Yes	0	3	6
250	R:R:F272	R:R:V225	2.62	Yes	Yes	1	9	6
251	R:R:S327	R:R:Y330	2.54	No	No	0	8	8
252	R:R:F179	R:R:K117	2.48	Yes	No	0	5	7
253	R:R:F165	R:R:K161	2.48	No	No	0	4	3
254	R:R:V212	R:R:W215	2.45	No	No	0	6	4
255	R:R:F179	R:R:L118	2.44	Yes	No	0	5	5
256	R:R:F203	R:R:L209	2.44	No	No	0	6	4
257	R:R:I235	R:R:Y142	2.42	No	Yes	0	8	8
258	R:R:C116	R:R:G183	1.96	Yes	No	0	9	4
259	R:R:C304	R:R:G282	1.96	No	No	0	5	4
260	R:R:A40	R:R:P41	1.87	No	No	0	2	2
261	R:R:G57	R:R:V56	1.84	No	No	0	8	6
262	R:R:G236	R:R:V262	1.84	No	No	0	5	7
263	R:R:G158	R:R:T156	1.82	No	No	0	4	7
264	R:R:G208	R:R:T211	1.82	No	No	0	2	4
265	R:R:A129	R:R:A171	1.79	No	No	0	6	8
266	R:R:P320	R:R:T64	1.75	Yes	No	0	9	9
267	R:R:C50	R:R:V310	1.71	Yes	No	0	6	5
268	R:R:C116	R:R:V184	1.71	Yes	No	0	9	5
269	R:R:A151	R:R:V155	1.7	No	No	0	6	7
270	R:R:C50	R:R:T49	1.69	Yes	No	0	6	5
271	R:R:I321	R:R:P320	1.69	No	Yes	0	6	9
272	R:R:L149	R:R:P148	1.64	No	No	0	7	8
273	R:R:A271	R:R:I318	1.62	No	No	0	6	7
274	R:R:V166	R:R:V170	1.6	No	No	0	4	4
275	R:R:V212	R:R:V216	1.6	No	No	0	6	5
276	R:R:T229	R:R:V225	1.59	No	Yes	0	5	6
277	R:R:T229	R:R:V230	1.59	No	No	0	5	4
278	R:R:T229	R:R:V269	1.59	No	No	0	5	8
279	R:R:T261	R:R:V262	1.59	No	No	0	8	7
280	R:R:A40	R:R:L42	1.58	No	No	0	2	3
281	R:R:A317	R:R:L53	1.58	No	No	0	7	7
282	R:R:M65	R:R:S83	1.53	No	No	0	7	6
283	R:R:L66	R:R:S69	1.5	No	No	0	3	3
284	R:R:L234	R:R:S233	1.5	No	No	0	5	4
285	R:R:L306	R:R:V46	1.49	No	No	0	4	4
286	R:R:L100	R:R:V51	1.49	No	No	0	7	4
287	R:R:L322	R:R:V267	1.49	No	No	0	8	6
288	R:R:L338	R:R:V334	1.49	No	Yes	0	7	6
289	R:R:D113	R:R:V184	1.46	No	No	0	4	5
290	R:R:F147	R:R:P148	1.44	No	No	0	6	8
291	R:R:K161	R:R:L80	1.41	No	No	0	3	5
292	R:R:L91	R:R:L94	1.38	Yes	No	0	7	5
293	R:R:H186	R:R:T195	1.37	No	No	0	2	3
294	R:R:F54	R:R:V55	1.31	No	No	0	7	5
295	R:R:R75	R:R:V68	1.31	No	No	0	7	7
296	R:R:R150	R:R:V154	1.31	No	No	0	5	4
297	R:R:F179	R:R:V180	1.31	Yes	No	0	5	4
298	R:R:D255	R:R:Q256	1.31	No	No	0	1	4
299	R:R:F335	R:R:V334	1.31	No	Yes	0	3	6
300	R:R:F270	R:R:L274	1.22	No	No	0	5	5
301	R:R:F335	R:R:R331	1.07	No	No	0	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.0664	11	1	0
2	R:R:L43	6.54	4	0	5
3	R:R:C50	2.4525	4	1	6
4	R:R:F71	6.07	6	2	5
5	R:R:Y81	7.03667	6	0	8
6	R:R:D89	7.6675	4	1	9
7	R:R:L91	4.715	4	0	7
8	R:R:F93	5.272	5	1	6
9	R:R:M96	9.1025	4	1	7
10	R:R:D99	7.2225	4	1	6
11	R:R:C116	3.33	4	4	9
12	R:R:Q120	10.49	4	1	4
13	R:R:F121	6.9925	4	0	6
14	R:R:K130	6.9375	4	1	9
15	R:R:Y142	6.886	5	0	8
16	R:R:W168	6.595	4	3	9
17	R:R:I178	4.195	4	1	4
18	R:R:F179	5.3075	4	0	5
19	R:R:R199	10.6075	4	5	3
20	R:R:M213	5.078	5	0	5
21	R:R:F220	11.045	4	0	6
22	R:R:F221	5.952	5	1	8
23	R:R:P224	4.845	4	0	9
24	R:R:V225	2.3625	4	1	6
25	R:R:Y232	7.248	5	0	9
26	R:R:F272	6.148	5	1	9
27	R:R:W276	6.21875	8	1	8
28	R:R:F279	6.966	5	1	6
29	R:R:R283	12.45	4	1	6
30	R:R:F286	6.7425	4	1	4
31	R:R:N305	6.9625	4	1	4
32	R:R:F312	7.126	5	1	7
33	R:R:Y313	10.606	5	1	7
34	R:R:P320	4.725	4	0	9
35	R:R:Y323	6.295	4	0	9
36	R:R:V334	3.6525	4	0	6
37	R:R:L337	4.2125	4	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L103	16.5816	6.43	Yes	No	0	0	4
2	R:R:L103	R:R:L43	21.8489	5.54	No	Yes	0	4	5
3	R:R:L43	R:R:V46	13.7376	4.47	Yes	No	0	5	4
4	L:L:?1	R:R:D99	19.8856	3.94	Yes	Yes	1	0	6
5	R:R:D99	R:R:Y313	26.516	3.45	Yes	Yes	1	6	7
6	R:R:M96	R:R:Y313	11.8921	22.75	Yes	Yes	1	7	7
7	R:R:F93	R:R:Y313	24.4405	5.16	Yes	Yes	1	6	7
8	R:R:F93	R:R:I58	12.1838	5.02	Yes	No	1	6	6
9	R:R:D89	R:R:N61	20.0482	9.42	Yes	No	0	9	9
10	R:R:N61	R:R:P320	16.5031	11.4	No	Yes	0	9	9
11	L:L:?1	R:R:R283	82.577	19.06	Yes	Yes	1	0	6
12	R:R:F279	R:R:R283	64.9464	12.83	Yes	Yes	1	6	6
13	R:R:F279	R:R:W276	58.5068	6.01	Yes	Yes	1	6	8
14	R:R:K130	R:R:W276	30.9138	9.28	Yes	Yes	1	9	8
15	R:R:D89	R:R:K130	14.5117	9.68	Yes	Yes	1	9	9
16	R:R:F272	R:R:W276	100	13.03	Yes	Yes	1	9	8
17	R:R:F272	R:R:I134	62.9943	5.02	Yes	No	0	9	8
18	R:R:I134	R:R:Y323	56.6051	6.04	No	Yes	0	8	9
19	R:R:L82	R:R:Y323	58.4899	5.86	No	Yes	0	8	9
20	R:R:L82	R:R:N324	56.8015	6.87	No	No	0	8	7
21	R:R:N324	R:R:Y330	55.0625	19.77	No	No	0	7	8
22	R:R:V334	R:R:Y330	51.5398	8.83	Yes	No	0	6	8
23	R:R:L63	R:R:V334	35.3228	2.98	No	Yes	0	6	6
24	R:R:L63	R:R:V67	33.6512	4.47	No	No	0	6	8
25	R:R:L337	R:R:V67	31.744	2.98	Yes	No	0	5	8
26	R:R:F71	R:R:L337	22.0564	3.65	Yes	Yes	2	5	5
27	R:R:F71	R:R:L74	14.2312	3.65	Yes	No	0	5	8
28	R:R:L74	R:R:N79	10.2317	4.12	No	No	0	8	8
29	R:R:F220	R:R:Y128	10.3943	28.88	Yes	No	0	6	6
30	R:R:F220	R:R:L132	15.4709	6.09	Yes	No	0	6	6
31	R:R:I58	R:R:L90	10.7141	2.85	No	No	0	6	7
32	L:L:?1	R:R:Q120	28.2044	17.01	Yes	Yes	1	0	4
33	R:R:I178	R:R:Q120	23.4476	4.12	Yes	Yes	1	4	4
34	R:R:F121	R:R:I178	23.2344	3.77	Yes	Yes	0	6	4
35	R:R:F121	R:R:F172	10.1587	6.43	Yes	No	0	6	4
36	R:R:S84	R:R:T133	10.0802	3.2	No	No	0	9	8
37	R:R:K130	R:R:N319	15.7738	4.2	Yes	No	1	9	9
38	R:R:M85	R:R:N319	18.7132	7.01	No	No	0	9	9
39	R:R:M85	R:R:T133	17.2884	6.02	No	No	0	9	8
40	R:R:F312	R:R:Y313	34.9246	11.35	Yes	Yes	1	7	7
41	R:R:F312	R:R:I92	13.9732	6.28	Yes	No	0	7	7
42	R:R:C126	R:R:I92	12.0099	4.91	No	No	0	8	7
43	R:R:C126	R:R:L91	10.0353	4.76	No	Yes	0	8	7
44	R:R:D99	R:R:F119	17.3669	10.75	Yes	No	0	6	4
45	R:R:F119	R:R:L98	19.448	9.74	No	No	0	4	5
46	L:L:?1	R:R:R102	25.3548	17.65	Yes	No	0	0	5
47	R:R:R102	R:R:W109	23.3971	4	No	No	0	5	7
48	R:R:E197	R:R:W109	19.3246	4.36	No	No	0	4	7
49	R:R:L115	R:R:L98	17.3052	2.77	No	No	0	5	5
50	R:R:F111	R:R:L115	12.9971	9.74	No	No	0	6	5
51	R:R:F121	R:R:F179	11.3536	15	Yes	Yes	0	6	5
52	R:R:R283	R:R:S217	20.5531	3.95	Yes	No	0	6	6
53	R:R:F220	R:R:V131	13.8049	3.93	Yes	No	0	6	8
54	R:R:V131	R:R:W276	12.0211	3.68	No	Yes	0	8	8
55	R:R:P224	R:R:V131	10.916	3.53	Yes	No	0	9	8
56	R:R:F272	R:R:P224	10.6524	5.78	Yes	Yes	0	9	9
57	R:R:H280	R:R:S217	21.5516	5.58	No	No	0	7	6
58	R:R:F221	R:R:H280	48.3985	10.18	Yes	No	0	8	7
59	R:R:F221	R:R:V225	37.2581	2.62	Yes	Yes	1	8	6
60	R:R:T229	R:R:V225	85.3873	1.59	No	Yes	0	5	6
61	R:R:T229	R:R:V269	22.9988	1.59	No	No	0	5	8
62	R:R:V269	R:R:Y232	19.2797	5.05	No	Yes	0	8	9
63	R:R:F279	R:R:H280	28.7597	4.53	Yes	No	0	6	7
64	R:R:F272	R:R:V225	51.7922	2.62	Yes	Yes	1	9	6
65	R:R:R141	R:R:Y323	10.299	8.23	No	Yes	0	9	9
66	R:R:V268	R:R:Y323	16.0823	5.05	No	Yes	0	8	9
67	R:R:V268	R:R:Y232	10.2765	3.79	No	Yes	0	8	9
68	R:R:T229	R:R:V230	89.0054	1.59	No	No	0	5	4
69	R:R:L231	R:R:V230	86.4587	2.98	No	No	0	7	4
70	R:R:L231	R:R:Y142	79.0879	9.38	No	Yes	0	7	8
71	R:R:F147	R:R:Y142	22.5893	6.19	No	Yes	0	6	8
72	R:R:L234	R:R:Y142	11.5499	7.03	No	Yes	0	5	8
73	R:R:I235	R:R:Y142	36.8935	2.42	No	Yes	0	8	8
74	R:R:F147	R:R:R150	14.0742	5.34	No	No	0	6	5
75	R:R:R150	R:R:V154	11.2133	1.31	No	No	0	5	4
76	L:L:?1	R:R:M213	22.3032	4.11	Yes	Yes	0	0	5
77	R:R:E197	R:R:R199	17.1818	5.82	No	Yes	0	4	3
78	L:L:?1	R:R:F286	31.5028	16.28	Yes	Yes	1	0	4
79	R:R:F286	R:R:F290	41.123	3.22	Yes	No	0	4	1
80	R:R:F290	R:R:V205	19.2124	6.55	No	No	0	1	4
81	R:R:E291	R:R:V205	16.0375	4.28	No	No	0	1	4
82	R:R:F221	R:R:L277	12.2511	7.31	Yes	No	0	8	6
83	R:R:G236	R:R:I235	31.3401	3.53	No	No	0	5	8
84	R:R:G236	R:R:V262	28.5466	1.84	No	No	0	5	7
85	R:R:V262	R:R:W240	17.2491	4.9	No	No	0	7	4
86	R:R:K259	R:R:W240	14.3995	8.12	No	No	0	5	4
87	R:R:F335	R:R:V334	12.0267	1.31	No	Yes	0	3	6
88	R:R:N305	R:R:S308	22.8081	5.96	Yes	No	0	4	7
89	R:R:G282	R:R:N305	10.9329	5.09	No	Yes	0	4	4
90	R:R:F290	R:R:S289	19.2124	5.28	No	No	0	1	2
91	R:R:S289	R:R:S294	16.0375	3.26	No	No	0	2	6
92	R:R:I321	R:R:P320	11.1011	1.69	No	Yes	0	6	9
93	R:R:F312	R:R:W276	33.6961	4.01	Yes	Yes	1	7	8
94	R:R:T133	R:R:Y81	11.1067	3.75	No	Yes	0	8	8
95	R:R:F279	R:R:S308	23.5261	3.96	Yes	No	0	6	7
96	R:R:F286	R:R:N305	15.5775	4.83	Yes	Yes	1	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D99	3.94	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R102	17.65	1	Yes	No	0	5	0	1
L:L:?1	R:R:L103	6.43	1	Yes	No	0	4	0	1
L:L:?1	R:R:Q120	17.01	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S123	3.49	1	Yes	No	0	6	0	1
L:L:?1	R:R:E124	7.7	1	Yes	No	0	4	0	1
L:L:?1	R:R:M213	4.11	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R283	19.06	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F286	16.28	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q302	3.09	1	Yes	No	0	3	0	1
L:L:?1	R:R:N305	11.97	1	Yes	Yes	0	4	0	1
R:R:P39	R:R:Q302	4.74	0	No	No	4	3	2	1
R:R:L103	R:R:L43	5.54	0	No	Yes	4	5	1	2
R:R:D99	R:R:F119	10.75	1	Yes	No	6	4	1	2
R:R:D99	R:R:F309	10.75	1	Yes	No	6	5	1	2
R:R:D99	R:R:Y313	3.45	1	Yes	Yes	6	7	1	2
R:R:R102	R:R:W109	4	0	No	No	5	7	1	2
R:R:F309	R:R:L103	9.74	1	No	No	5	4	2	1
R:R:F119	R:R:Q120	9.37	0	No	Yes	4	4	2	1
R:R:I178	R:R:Q120	4.12	1	Yes	Yes	4	4	2	1
R:R:Q120	R:R:V182	11.46	1	Yes	No	4	4	1	2
R:R:E124	R:R:Y128	17.96	1	No	No	4	6	1	2
R:R:E124	R:R:R283	13.96	1	No	Yes	4	6	1	1
R:R:S217	R:R:Y128	3.82	0	No	No	6	6	2	2
R:R:M213	R:R:P177	6.71	0	Yes	No	5	7	1	2
R:R:I178	R:R:L181	4.28	1	Yes	No	4	4	2	2
R:R:I178	R:R:V182	4.61	1	Yes	No	4	4	2	2
R:R:L181	R:R:V182	2.98	1	No	No	4	4	2	2
R:R:L181	R:R:M213	5.65	1	No	Yes	4	5	2	1
R:R:M213	R:R:V216	6.09	0	Yes	No	5	5	1	2
R:R:R283	R:R:S217	3.95	1	Yes	No	6	6	1	2
R:R:F279	R:R:R283	12.83	1	Yes	Yes	6	6	2	1
R:R:F279	R:R:S308	3.96	1	Yes	No	6	7	2	2
R:R:G282	R:R:N305	5.09	0	No	Yes	4	4	2	1
R:R:F286	R:R:F290	3.22	1	Yes	No	4	1	1	2
R:R:F286	R:R:N305	4.83	1	Yes	Yes	4	4	1	1
R:R:N305	R:R:S308	5.96	1	Yes	No	4	7	1	2
R:R:F309	R:R:Y313	10.32	1	No	Yes	5	7	2	2
R:R:L209	R:R:M213	2.83	0	No	Yes	4	5	2	1
R:R:F286	R:R:S301	2.64	1	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7NA8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	270
Number of Links	301
Number of Hubs	37
Number of Links mediated by Hubs	145
Number of Communities	5
Number of Nodes involved in Communities	42
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	52110
Length Of Smallest Path	3
Average Path Length	12.5726
Length of Longest Path	29
Minimum Path Strength	1.19
Average Path Strength	6.59487
Maximum Path Strength	23.42
Minimum Path Correlation	0.7
Average Path Correlation	0.922799
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.4289
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.3954
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • growth hormone secretagogue receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • amide binding • peptide hormone binding • hormone binding • identical protein binding • growth hormone-releasing hormone receptor activity • digestive system process • regulation of system process • regulation of gastric motility • regulation of digestive system process • digestion • gastric motility • regulation of multicellular organismal process • response to peptide hormone • cellular response to peptide hormone stimulus • cellular response to insulin-like growth factor stimulus • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • interleukin-6 production • regulation of interleukin-6 production • negative regulation of interleukin-6 production • negative regulation of behavior • negative regulation of locomotion • locomotion involved in locomotory behavior • behavior • regulation of behavior • negative regulation of locomotion involved in locomotory behavior • locomotory behavior • regulation of locomotion • regulation of locomotion involved in locomotory behavior • locomotion • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • growth hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of growth hormone secretion • regulation of peptide transport • export from cell • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • intestinal motility • positive regulation of small intestinal transit • positive regulation of biological process • positive regulation of digestive system process • positive regulation of multicellular organismal process • small intestinal transit • regulation of small intestinal transit • cell surface receptor signaling pathway • insulin-like growth factor receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of insulin-like growth factor receptor signaling pathway • regulation of insulin-like growth factor receptor signaling pathway • positive regulation of cellular process • regulation of response to stimulus • positive regulation of signaling • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • response to glucocorticoid • response to corticosteroid • response to steroid hormone • response to dexamethasone • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of epithelial cell proliferation • regulation of vascular endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of cell population proliferation • positive regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • vascular endothelial cell proliferation • epithelial cell proliferation • positive regulation of vascular endothelial cell proliferation • response to growth hormone • response to thyroid hormone • cellular response to thyroid hormone stimulus • response to acid chemical • response to L-glutamate • response to amino acid • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • cell junction assembly • regulation of synapse structure or activity • regulation of synapse assembly • synapse organization • cellular component organization or biogenesis • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • response to gonadotropin • response to follicle-stimulating hormone • postsynapse organization • regulation of postsynapse organization • regulation of hindgut contraction • muscle contraction • muscle system process • regulation of muscle system process • hindgut contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • adult feeding behavior • adult behavior • feeding behavior • actin polymerization or depolymerization • organelle organization • actin cytoskeleton organization • actin filament organization • actin filament-based process • supramolecular fiber organization • cytoskeleton organization • positive regulation of smooth muscle contraction • intestine smooth muscle contraction • regulation of gastro-intestinal system smooth muscle contraction • positive regulation of small intestine smooth muscle contraction • regulation of small intestine smooth muscle contraction • small intestine smooth muscle contraction • gastro-intestinal system smooth muscle contraction • phasic smooth muscle contraction • positive regulation of gastro-intestinal system smooth muscle contraction • positive regulation of muscle contraction • leukocyte apoptotic process • regulation of programmed cell death • macrophage apoptotic process • negative regulation of leukocyte apoptotic process • myeloid cell apoptotic process • regulation of leukocyte apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of macrophage apoptotic process • cell death • negative regulation of apoptotic process • regulation of macrophage apoptotic process • inflammatory cell apoptotic process • negative regulation of myeloid cell apoptotic process • apoptotic process • regulation of myeloid cell apoptotic process • programmed cell death • response to nutrient levels • regulation of response to nutrient levels • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of response to stimulus • negative regulation of appetite • regulation of response to food • response to food • regulation of appetite • oxoacid metabolic process • ketone metabolic process • regulation of lipid metabolic process • organic acid metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • positive regulation of fatty acid metabolic process • fatty acid metabolic process • carboxylic acid metabolic process • primary metabolic process • regulation of ketone metabolic process • regulation of fatty acid metabolic process • monocarboxylic acid metabolic process • positive regulation of small molecule metabolic process • lipid metabolic process • hormone-mediated signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • interleukin-1 production • regulation of interleukin-1 beta production • negative regulation of interleukin-1 beta production • negative regulation of interleukin-1 production • regulation of interleukin-1 production • interleukin-1 beta production • biological process involved in interspecies interaction between organisms • response to other organism • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • positive regulation of appetite • positive regulation of response to food • positive regulation of response to nutrient levels • negative regulation of protein transport • establishment of protein localization • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • macromolecule localization • insulin secretion • ghrelin secretion • cellular localization • protein localization to synapse • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane • regulation of protein localization to synapse • neurotransmitter receptor localization to postsynaptic specialization membrane • regulation of protein localization to membrane • regulation of receptor localization to synapse • protein localization to postsynaptic specialization membrane • protein localization to cell periphery • protein localization to postsynaptic membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • protein-containing complex localization • regulation of postsynaptic membrane neurotransmitter receptor levels • regulation of cellular localization • protein localization to organelle • protein localization to postsynapse • protein localization to cell junction • receptor localization to synapse • multi-multicellular organism process • placenta development • maternal process involved in female pregnancy • tissue development • maternal placenta development • female pregnancy • multi-organism reproductive process • decidualization • learning or memory • cognition • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of developmental growth • regulation of sprouting angiogenesis • angiogenesis • regulation of vasculature development • tube morphogenesis • positive regulation of sprouting angiogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • sprouting angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • regulation of eating behavior • positive regulation of feeding behavior • eating behavior • positive regulation of eating behavior • positive regulation of behavior • regulation of feeding behavior • response to insulin • cellular response to insulin stimulus • monoamine transport • negative regulation of amine transport • regulation of catecholamine secretion • organic hydroxy compound transport • catecholamine transport • negative regulation of norepinephrine secretion • norepinephrine transport • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • transmission of nerve impulse • regulation of nervous system process • regulation of transmission of nerve impulse • response to estradiol • glutamatergic synapse • postsynapse • plasma membrane region • synaptic membrane • cell surface • membrane microdomain • membrane raft • Schaffer collateral - CA1 synapse
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	1KD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	1KD
Name	Ibutamoren
Synonyms	2-amino-n-((r)-2-(benzyloxy)-1-((1-(methylsulfonyl)spiro(indoline-3,4'-piperidin)-1'-yl)carbonyl)ethyl)-2-methylpropionamide Ibutamoren mesylate Ibutamoren 2-amino-n-(3-(benzyloxy)-1-(1-methanesulfonyl-1,2-dihydrospiro(indole-3,4'-piperidin)-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide
Identifier
Formula	C27 H36 N4 O5 S
Molecular Weight	528.664
SMILES
PubChem	178024
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	1
Total Bonds	76
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q92847
Sequence	>7NA8_nogp_Chain_R P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F R E L R T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q P W N F G D L L C K L F Q F V S E S C T Y A K V L T I T A L S V E R Y F A I C F P L R A K V V V T K G R V K L V I F V I W A V A F C S A G P I F V L V G V E H E P W D T N E C R P T E F A V R S G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E P G S L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K Y R V A V F R L L G F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KO5	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 57400002	-	-	3.3	2020-08-12	doi.org/10.1038/s41467-020-17554-1
	7F9Y	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Y (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-28	-		2.9	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7F9Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	GHRP-6	-		3.2	2021-08-18	doi.org/10.1038/s41467-021-25364-2
	7NA7	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-	Gi1/β1/γ2	2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA7 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin-27	-		2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA8	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-	Gi1/β1/γ2	2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7NA8 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PubChem 178024	-		2.7	2021-12-15	doi.org/10.1038/s41467-021-26735-5
	7F83	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	PF-05190457	-	-	2.94	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	7W2Z	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-	Go/β1/γ2	2.8	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	7W2Z (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Ghrelin	-		2.8	2022-01-19	doi.org/10.1038/s41467-022-27975-9
	8JSR	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	8JSR (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.9	2025-01-22	doi.org/10.1038/s41594-024-01481-6
	9UY3	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.52	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9UY3 (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Anamorelin	-		2.52	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7
	9V2N (No Gprot)	A	Peptide	Ghrelin	Ghrelin	Homo sapiens	Macimorelin	-		2.63	2025-07-02	doi.org/10.1038/s41401-025-01606-7

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