psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L34	R:R:Q33	3.99	No	No	0	2	4
2	R:R:K40	R:R:T37	4.5	No	No	0	5	4
3	E:E:D71	R:R:R38	3.57	No	No	0	3	5
4	E:E:I63	R:R:N39	5.66	No	No	0	5	5
5	R:R:K40	R:R:Y91	4.78	No	Yes	0	5	5
6	R:R:I41	R:R:Y91	10.88	No	Yes	0	6	5
7	R:R:M42	R:R:Q45	6.8	No	Yes	0	3	5
8	E:E:W59	R:R:T43	3.64	Yes	No	0	7	5
9	R:R:Q45	R:R:W69	13.14	Yes	Yes	0	5	7
10	E:E:Y66	R:R:Q45	6.76	Yes	Yes	0	9	5
11	E:E:A70	R:R:Q45	4.55	No	Yes	0	7	5
12	E:E:F93	R:R:Q45	5.86	No	Yes	0	9	5
13	R:R:E47	R:R:Y46	4.49	Yes	Yes	2	6	2
14	R:R:Q50	R:R:Y46	16.91	Yes	Yes	2	4	2
15	E:E:W59	R:R:Y46	7.72	Yes	Yes	2	7	2
16	E:E:Y66	R:R:Y46	8.94	Yes	Yes	2	9	2
17	E:E:F101	R:R:Y46	9.28	No	Yes	2	9	2
18	E:E:R109	R:R:Y46	13.38	Yes	Yes	2	5	2
19	R:R:E47	R:R:Q50	5.1	Yes	Yes	2	6	4
20	E:E:R109	R:R:E47	10.47	Yes	Yes	2	5	6
21	R:R:C48	R:R:I52	3.27	No	No	0	9	5
22	R:R:C48	R:R:W69	9.14	No	Yes	0	9	7
23	R:R:C48	R:R:C74	7.28	No	No	0	9	9
24	R:R:W69	R:R:Y49	10.61	Yes	Yes	0	7	3
25	E:E:D90	R:R:Y49	3.45	No	Yes	0	8	3
26	E:E:F93	R:R:Y49	15.47	No	Yes	0	9	3
27	E:E:H97	R:R:Y49	6.53	Yes	Yes	0	9	3
28	E:E:H97	R:R:Q50	11.13	Yes	Yes	2	9	4
29	E:E:F101	R:R:Q50	3.51	No	Yes	2	9	4
30	R:R:K51	R:R:R67	6.19	No	No	0	3	4
31	R:R:K51	R:R:N76	8.39	No	No	0	3	6
32	R:R:I52	R:R:R67	13.78	No	No	0	5	4
33	E:E:L94	R:R:I52	5.71	No	No	0	6	5
34	R:R:M53	R:R:Q54	4.08	No	No	8	2	2
35	E:E:R102	R:R:M53	11.17	No	No	8	5	2
36	E:E:R102	R:R:Q54	4.67	No	No	8	5	2
37	E:E:I106	R:R:Q54	4.12	No	No	0	4	2
38	R:R:D77	R:R:Y64	14.94	No	No	0	4	3
39	R:R:C105	R:R:C65	7.28	No	No	0	9	9
40	R:R:C65	R:R:N110	4.72	No	No	0	9	5
41	R:R:C65	R:R:W111	19.59	No	Yes	0	9	9
42	R:R:D77	R:R:R67	13.1	No	No	0	4	4
43	R:R:T68	R:R:W111	6.06	No	Yes	0	5	9
44	E:E:D90	R:R:T68	5.78	No	No	0	8	5
45	R:R:G71	R:R:W69	9.85	No	Yes	0	4	7
46	R:R:D70	R:R:W75	7.82	No	Yes	0	9	9
47	R:R:D70	R:R:Y124	9.2	No	Yes	0	9	4
48	L:L:F11	R:R:G71	3.01	Yes	No	0	0	4
49	R:R:W72	R:R:Y91	4.82	Yes	Yes	1	5	5
50	R:R:F92	R:R:W72	9.02	Yes	Yes	1	6	5
51	R:R:F95	R:R:W72	6.01	Yes	Yes	1	5	5
52	R:R:W72	R:R:Y124	14.47	Yes	Yes	0	5	4
53	L:L:F11	R:R:W72	8.02	Yes	Yes	1	0	5
54	R:R:L73	R:R:W75	4.56	Yes	Yes	7	5	9
55	R:R:L73	R:R:Q86	5.32	Yes	No	7	5	5
56	R:R:L73	R:R:P89	11.49	Yes	No	0	5	8
57	R:R:L73	R:R:V101	4.47	Yes	No	7	5	7
58	R:R:L73	R:R:Y124	5.86	Yes	Yes	0	5	4
59	R:R:S84	R:R:W75	7.41	No	Yes	0	7	9
60	R:R:Q86	R:R:W75	24.09	No	Yes	7	5	9
61	R:R:V101	R:R:W75	4.9	No	Yes	7	7	9
62	R:R:K103	R:R:W75	24.37	No	Yes	0	8	9
63	R:R:T82	R:R:V78	6.35	No	Yes	0	5	7
64	R:R:S84	R:R:V78	3.23	No	Yes	0	7	7
65	R:R:C105	R:R:V78	3.42	No	Yes	0	9	7
66	R:R:V78	R:R:W111	3.68	Yes	Yes	0	7	9
67	R:R:K100	R:R:M85	4.32	No	No	0	3	4
68	R:R:C88	R:R:P89	3.77	Yes	No	0	9	8
69	R:R:C88	R:R:F95	5.59	Yes	Yes	1	9	5
70	R:R:C88	R:R:E99	9.12	Yes	No	1	9	5
71	R:R:C127	R:R:C88	7.28	No	Yes	1	9	9
72	R:R:P89	R:R:Y91	18.08	No	Yes	0	8	5
73	R:R:D90	R:R:P97	3.22	No	No	0	3	3
74	R:R:F92	R:R:Y91	9.28	Yes	Yes	1	6	5
75	R:R:D94	R:R:F92	4.78	Yes	Yes	1	5	6
76	R:R:F92	R:R:F95	11.79	Yes	Yes	1	6	5
77	L:L:T4	R:R:F92	10.38	No	Yes	1	0	6
78	L:L:F1	R:R:Q93	10.54	No	No	0	0	4
79	R:R:D94	R:R:F95	7.17	Yes	Yes	1	5	5
80	R:R:D94	R:R:N128	8.08	Yes	No	0	5	3
81	L:L:F1	R:R:D94	10.75	No	Yes	0	0	5
82	L:L:T4	R:R:D94	13.01	No	Yes	1	0	5
83	R:R:C127	R:R:F95	13.97	No	Yes	1	9	5
84	L:L:T4	R:R:F95	5.19	No	Yes	1	0	5
85	R:R:D96	R:R:E99	6.5	No	No	0	5	5
86	R:R:C127	R:R:E99	3.04	No	No	1	9	5
87	R:R:K103	R:R:W111	20.89	No	Yes	0	8	9
88	R:R:K103	R:R:T122	10.51	No	No	0	8	7
89	R:R:F112	R:R:I104	12.56	No	No	0	5	4
90	R:R:D106	R:R:N110	6.73	No	No	0	5	5
91	R:R:F112	R:R:H114	6.79	No	Yes	0	5	4
92	R:R:N118	R:R:R113	13.26	No	No	0	6	1
93	R:R:H114	R:R:P115	9.15	Yes	No	0	4	3
94	R:R:H114	R:R:S117	6.97	Yes	No	9	4	4
95	R:R:H114	R:R:W121	14.81	Yes	No	0	4	8
96	L:L:S8	R:R:H114	8.37	No	Yes	9	0	4
97	R:R:R119	R:R:S117	5.27	No	No	0	4	4
98	L:L:S8	R:R:S117	6.52	No	No	9	0	4
99	E:E:F83	R:R:R119	19.24	No	No	0	5	4
100	R:R:N123	R:R:W121	9.04	No	No	0	8	8
101	R:R:T122	R:R:Y124	7.49	No	Yes	0	7	4
102	R:R:N123	R:R:T125	8.77	No	No	10	8	6
103	R:R:N123	R:R:Q126	6.6	No	No	10	8	5
104	R:R:Q126	R:R:T125	8.5	No	No	10	5	6
105	L:L:V6	R:R:N128	11.82	No	No	0	0	3
106	R:R:N130	R:R:V129	8.87	No	No	0	2	2
107	R:R:E133	R:R:N130	11.83	No	No	0	1	2
108	R:R:H132	R:R:T131	4.11	No	No	0	2	1
109	R:R:K136	R:R:N140	8.39	No	No	0	2	4
110	R:R:L141	R:R:T137	2.95	Yes	No	0	6	4
111	R:R:L139	R:R:Y143	5.86	No	No	0	3	4
112	R:R:N140	R:R:Y367	6.98	No	No	0	4	6
113	R:R:D366	R:R:L141	5.43	No	Yes	11	6	6
114	R:R:L141	R:R:Y367	7.03	Yes	No	11	6	6
115	R:R:H370	R:R:L141	27	No	Yes	0	7	6
116	R:R:F142	R:R:Y143	4.13	Yes	No	0	6	4
117	R:R:F142	R:R:I146	5.02	Yes	No	0	6	6
118	R:R:F142	R:R:T196	6.49	Yes	No	0	6	3
119	R:R:I371	R:R:L144	5.71	No	No	12	6	6
120	R:R:F375	R:R:L144	3.65	Yes	No	12	7	6
121	R:R:L195	R:R:T145	4.42	No	No	0	7	7
122	R:R:H374	R:R:T145	20.54	Yes	No	0	9	7
123	R:R:F375	R:R:I147	3.77	Yes	No	0	7	5
124	R:R:F375	R:R:G148	9.03	Yes	No	0	7	9
125	R:R:H149	R:R:S188	9.76	No	No	0	7	8
126	R:R:H149	R:R:T191	6.85	No	No	0	7	7
127	R:R:H149	R:R:H374	8.36	No	Yes	0	7	9
128	R:R:L151	R:R:L378	5.54	No	Yes	0	5	6
129	R:R:G377	R:R:S152	3.71	No	No	0	9	9
130	R:R:L378	R:R:S152	7.51	Yes	No	0	6	9
131	R:R:I153	R:R:S188	3.1	No	No	0	6	8
132	R:R:I153	R:R:V189	3.07	No	No	0	6	4
133	R:R:L378	R:R:S155	3	Yes	No	0	6	6
134	R:R:S155	R:R:S381	6.52	No	No	0	6	8
135	R:R:L156	R:R:V185	4.47	No	No	0	9	7
136	R:R:L156	R:R:S381	3	No	No	0	9	8
137	R:R:L157	R:R:V185	2.98	No	No	0	3	7
138	R:R:F181	R:R:S159	5.28	No	No	0	8	8
139	R:R:C385	R:R:S159	6.89	No	No	0	9	8
140	R:R:F163	R:R:I162	6.28	Yes	No	0	7	8
141	R:R:C385	R:R:I162	3.27	No	No	0	9	8
142	R:R:I162	R:R:V391	3.07	No	No	0	8	9
143	R:R:F163	R:R:I174	10.05	Yes	No	0	7	9
144	R:R:F163	R:R:F181	5.36	Yes	No	0	7	8
145	R:R:F164	R:R:K178	8.69	No	No	0	4	6
146	R:R:F166	R:R:Y165	5.16	No	No	0	7	3
147	R:R:F166	R:R:I394	3.77	No	No	0	7	8
148	R:R:C171	R:R:I174	4.91	No	No	0	8	9
149	R:R:Q172	R:R:Y236	9.02	Yes	Yes	4	7	8
150	R:R:Q172	R:R:Q250	8.96	Yes	Yes	4	7	6
151	R:R:L252	R:R:Q172	7.99	No	Yes	0	6	7
152	R:R:H177	R:R:R173	11.28	No	No	0	9	9
153	R:R:A334	R:R:R173	6.91	No	No	0	8	9
154	R:R:L176	R:R:W229	3.42	No	Yes	0	9	9
155	R:R:E233	R:R:L176	7.95	No	No	0	9	9
156	R:R:L176	R:R:Y236	5.86	No	Yes	0	9	8
157	R:R:E233	R:R:H177	7.39	No	No	0	9	9
158	R:R:F384	R:R:H177	13.58	Yes	No	0	8	9
159	R:R:N179	R:R:W229	12.43	No	Yes	0	8	9
160	R:R:N179	R:R:Y256	4.65	No	No	0	8	5
161	R:R:L180	R:R:M230	4.24	No	No	0	9	9
162	R:R:E233	R:R:L180	3.98	No	No	0	9	9
163	R:R:F182	R:R:W260	4.01	No	No	0	4	9
164	R:R:F184	R:R:S183	3.96	No	No	14	8	8
165	R:R:N226	R:R:S183	2.98	No	No	14	8	8
166	R:R:F184	R:R:N226	12.08	No	No	14	8	8
167	R:R:F184	R:R:V380	6.55	No	Yes	0	8	9
168	R:R:C186	R:R:L222	4.76	No	Yes	0	7	5
169	R:R:L222	R:R:N187	4.12	Yes	No	0	5	8
170	R:R:N187	R:R:N226	13.62	No	No	0	8	8
171	R:R:I193	R:R:V190	3.07	No	No	0	5	6
172	R:R:H219	R:R:T191	9.58	No	No	0	6	7
173	R:R:H194	R:R:V198	8.3	No	No	0	7	6
174	R:R:H194	R:R:S215	12.55	No	No	0	7	6
175	R:R:H194	R:R:Q216	7.42	No	No	0	7	6
176	R:R:C212	R:R:V198	3.42	Yes	No	0	9	6
177	R:R:L204	R:R:N201	8.24	No	No	0	4	4
178	R:R:N281	R:R:V205	5.91	No	No	0	4	4
179	R:R:P209	R:R:T207	3.5	Yes	No	0	5	3
180	R:R:K213	R:R:N208	9.79	No	No	3	8	6
181	R:R:N208	R:R:N281	8.17	No	No	0	6	4
182	R:R:C282	R:R:N208	3.15	Yes	No	3	9	6
183	R:R:P209	R:R:S211	3.56	Yes	No	0	5	4
184	R:R:C212	R:R:P209	3.77	Yes	Yes	3	9	5
185	R:R:C282	R:R:P209	3.77	Yes	Yes	3	9	5
186	R:R:C212	R:R:C282	7.28	Yes	Yes	3	9	9
187	R:R:C212	R:R:I284	3.27	Yes	No	0	9	6
188	R:R:C282	R:R:K213	4.85	Yes	No	3	9	8
189	R:R:K213	R:R:W283	18.57	No	Yes	3	8	8
190	R:R:L220	R:R:Q216	9.32	No	No	0	7	6
191	R:R:I284	R:R:Q216	4.12	No	No	0	6	6
192	R:R:A267	R:R:F217	4.16	No	No	0	6	6
193	R:R:I218	R:R:Y221	4.84	No	Yes	0	5	8
194	R:R:H219	R:R:M223	5.25	No	No	0	6	6
195	R:R:H270	R:R:L220	6.43	Yes	No	15	8	7
196	R:R:I294	R:R:L220	8.56	No	No	15	7	7
197	R:R:L222	R:R:Y221	3.52	Yes	Yes	5	5	8
198	R:R:C225	R:R:Y221	9.41	No	Yes	5	8	8
199	R:R:P263	R:R:Y221	8.34	Yes	Yes	5	9	8
200	R:R:A267	R:R:Y221	4	No	Yes	0	6	8
201	R:R:C225	R:R:L222	3.17	No	Yes	5	8	5
202	R:R:F228	R:R:G224	3.01	Yes	No	0	5	5
203	R:R:G224	R:R:I298	3.53	No	No	0	5	7
204	R:R:C225	R:R:P263	3.77	No	Yes	5	8	9
205	R:R:I298	R:R:Y227	12.09	No	No	16	7	8
206	R:R:L345	R:R:Y227	4.69	No	No	0	9	8
207	R:R:F349	R:R:Y227	8.25	Yes	No	16	8	8
208	R:R:F228	R:R:F262	12.86	Yes	Yes	5	5	4
209	R:R:F228	R:R:P263	5.78	Yes	Yes	5	5	9
210	R:R:C232	R:R:W229	7.84	No	Yes	0	7	9
211	R:R:G259	R:R:W229	7.04	No	Yes	0	9	9
212	R:R:W229	R:R:W260	9.37	Yes	No	0	9	9
213	R:R:I235	R:R:L231	4.28	Yes	Yes	0	6	8
214	R:R:L231	R:R:L258	5.54	Yes	No	0	8	6
215	R:R:L231	R:R:V304	4.47	Yes	No	0	8	6
216	R:R:L231	R:R:N305	6.87	Yes	No	0	8	9
217	R:R:C232	R:R:Y255	4.03	No	Yes	0	7	8
218	R:R:I235	R:R:Y255	6.04	Yes	Yes	0	6	8
219	R:R:F308	R:R:I235	7.54	No	Yes	0	8	6
220	E:E:V138	R:R:I235	3.07	No	Yes	0	9	6
221	R:R:L240	R:R:Y236	15.24	No	Yes	4	8	8
222	R:R:Q250	R:R:Y236	7.89	Yes	Yes	4	6	8
223	R:R:Y236	R:R:Y255	4.96	Yes	Yes	4	8	8
224	R:R:H238	R:R:V242	5.54	Yes	No	0	8	6
225	R:R:H238	R:R:V243	5.54	Yes	No	0	8	5
226	R:R:F308	R:R:H238	13.58	No	Yes	0	8	8
227	R:R:Q250	R:R:T239	8.5	Yes	No	4	6	7
228	R:R:T239	R:R:Y255	4.99	No	Yes	4	7	8
229	E:E:S141	R:R:T239	4.8	No	No	4	9	7
230	R:R:L240	R:R:Q250	3.99	No	Yes	4	8	6
231	R:R:F246	R:R:V245	5.24	No	No	0	6	7
232	R:R:F246	R:R:Y331	10.32	No	No	0	6	7
233	R:R:Q250	R:R:Y255	5.64	Yes	Yes	4	6	8
234	R:R:H251	R:R:M253	6.57	No	No	0	4	3
235	R:R:H251	R:R:W254	14.81	No	No	0	4	2
236	R:R:L252	R:R:Y255	5.86	No	Yes	0	6	8
237	R:R:L252	R:R:Y256	4.69	No	No	0	6	5
238	R:R:M253	R:R:Y256	4.79	No	No	0	3	5
239	R:R:F257	R:R:M253	6.22	No	No	0	3	3
240	E:E:Q140	R:R:W254	20.81	No	No	18	7	2
241	E:E:R143	R:R:W254	8	No	No	18	8	2
242	E:E:S141	R:R:Y255	6.36	No	Yes	4	9	8
243	R:R:F262	R:R:L258	3.65	Yes	No	0	4	6
244	E:E:V137	R:R:L258	4.47	No	No	0	9	6
245	R:R:F262	R:R:P263	4.33	Yes	Yes	5	4	9
246	E:E:T130	R:R:F262	5.19	Yes	Yes	0	9	4
247	E:E:V133	R:R:F262	13.11	No	Yes	0	7	4
248	R:R:I265	R:R:P266	3.39	No	No	0	4	6
249	R:R:H270	R:R:R274	13.54	Yes	No	0	8	7
250	R:R:H270	R:R:I293	7.95	Yes	No	0	8	8
251	R:R:H270	R:R:I294	5.3	Yes	No	15	8	7
252	R:R:R274	R:R:W283	16.99	No	Yes	0	7	8
253	R:R:L290	R:R:R274	3.64	No	No	0	3	7
254	R:R:N279	R:R:S275	2.98	No	No	3	6	3
255	R:R:S275	R:R:W283	3.71	No	Yes	3	3	8
256	R:R:L276	R:R:Y277	3.52	No	Yes	0	3	3
257	E:E:P114	R:R:Y277	8.34	Yes	Yes	0	9	3
258	E:E:I118	R:R:Y277	6.04	No	Yes	0	6	3
259	R:R:D280	R:R:Y278	22.99	No	Yes	6	4	6
260	R:R:S285	R:R:Y278	6.36	No	Yes	6	5	6
261	R:R:D287	R:R:Y278	5.75	No	Yes	6	3	6
262	R:R:T288	R:R:Y278	11.24	Yes	Yes	6	5	6
263	E:E:D113	R:R:Y278	6.9	Yes	Yes	6	9	6
264	R:R:N279	R:R:W283	7.91	No	Yes	3	6	8
265	R:R:D280	R:R:S285	7.36	No	No	6	4	5
266	R:R:D287	R:R:S285	7.36	No	No	6	3	5
267	R:R:L290	R:R:T288	2.95	No	Yes	0	3	5
268	R:R:L291	R:R:T288	4.42	No	Yes	0	5	5
269	E:E:D113	R:R:T288	10.12	Yes	Yes	6	9	5
270	R:R:H289	R:R:Y292	10.89	No	No	0	4	6
271	E:E:D113	R:R:H289	3.78	Yes	No	0	9	4
272	R:R:H295	R:R:L291	3.86	No	No	0	6	5
273	R:R:F349	R:R:H295	7.92	Yes	No	0	8	6
274	R:R:G296	R:R:P297	4.06	No	No	0	4	8
275	R:R:F349	R:R:I298	3.77	Yes	No	16	8	7
276	E:E:I127	R:R:A300	3.25	No	No	0	8	3
277	R:R:L302	R:R:L303	4.15	No	No	0	7	3
278	R:R:L302	R:R:V342	2.98	No	No	0	7	8
279	R:R:G346	R:R:L302	5.13	No	No	0	9	7
280	R:R:L306	R:R:V342	4.47	No	No	0	5	8
281	R:R:F307	R:R:F308	3.22	No	No	0	4	8
282	R:R:L309	R:R:V335	2.98	No	No	0	9	8
283	R:R:L309	R:R:T338	2.95	No	No	0	9	9
284	R:R:L309	R:R:L339	6.92	No	No	0	9	7
285	R:R:N311	R:R:R314	9.64	No	No	0	7	7
286	R:R:L330	R:R:N329	5.49	No	No	17	6	5
287	R:R:N329	R:R:Y331	11.63	No	No	17	5	7
288	R:R:L330	R:R:Y331	11.72	No	No	17	6	7
289	R:R:F384	R:R:T338	6.49	Yes	No	0	8	9
290	R:R:L341	R:R:V380	7.45	Yes	Yes	0	9	9
291	R:R:I383	R:R:L341	4.28	No	Yes	13	7	9
292	R:R:F384	R:R:L341	6.09	Yes	Yes	13	8	9
293	R:R:P343	R:R:V342	5.3	No	No	0	9	8
294	R:R:L344	R:R:L379	4.15	No	No	0	9	5
295	R:R:L345	R:R:Q376	3.99	No	No	0	9	9
296	R:R:I347	R:R:L372	5.71	No	No	0	7	6
297	R:R:E348	R:R:F349	9.33	Yes	Yes	0	8	8
298	R:R:E348	R:R:I352	5.47	Yes	No	0	8	7
299	R:R:E348	R:R:M373	9.47	Yes	No	0	8	7
300	R:R:L351	R:R:V350	2.98	No	No	0	5	6
301	R:R:L351	R:R:Y365	3.52	No	No	19	5	6
302	R:R:L351	R:R:M369	5.65	No	No	19	5	8
303	R:R:I352	R:R:P353	3.39	No	No	0	7	6
304	R:R:W354	R:R:Y365	23.15	No	No	0	5	6
305	R:R:M369	R:R:Y365	9.58	No	No	19	8	6
306	R:R:D366	R:R:Y367	5.75	No	No	11	6	6
307	R:R:H370	R:R:H374	9.55	No	Yes	0	7	9
308	R:R:F375	R:R:I371	8.79	Yes	No	12	7	6
309	R:R:H374	R:R:M373	5.25	Yes	No	0	9	7
310	R:R:F375	R:R:L378	3.65	Yes	Yes	0	7	6
311	R:R:F384	R:R:I383	8.79	Yes	No	13	8	7
312	R:R:C385	R:R:F386	4.19	No	No	0	9	8
313	R:R:E390	R:R:N388	7.89	No	No	0	9	9
314	R:R:N388	R:R:V391	8.87	No	No	0	9	9
315	R:R:R396	R:R:R397	3.2	Yes	No	20	5	7
316	R:R:N400	R:R:W399	9.04	No	No	0	4	5
317	L:L:P3	L:L:V2	3.53	No	No	0	0	0
318	E:E:W74	L:L:F11	3.01	No	Yes	1	7	0
319	E:E:W84	L:L:F11	3.01	Yes	Yes	1	7	0
320	E:E:E29	E:E:N31	13.15	No	No	0	5	1
321	E:E:C82	E:E:E29	6.08	No	No	0	8	5
322	E:E:T73	E:E:Y32	3.75	No	Yes	1	8	6
323	E:E:M76	E:E:Y32	3.59	Yes	Yes	1	4	6
324	E:E:A77	E:E:Y32	5.34	No	Yes	0	8	6
325	E:E:C82	E:E:Y32	5.38	No	Yes	0	8	6
326	E:E:N86	E:E:Y32	4.65	No	Yes	1	9	6
327	E:E:V89	E:E:Y32	3.79	Yes	Yes	1	8	6
328	E:E:G33	E:E:L36	3.42	No	Yes	1	3	5
329	E:E:E88	E:E:G33	6.55	Yes	No	1	4	3
330	E:E:E38	E:E:L35	5.3	No	No	1	3	3
331	E:E:L35	E:E:L39	8.3	No	No	1	3	1
332	E:E:L36	E:E:R37	6.07	Yes	No	0	5	4
333	E:E:E88	E:E:L36	3.98	Yes	Yes	1	4	5
334	E:E:F92	E:E:L36	3.65	Yes	Yes	0	5	5
335	E:E:E38	E:E:L39	3.98	No	No	1	3	1
336	E:E:L39	E:E:M76	4.24	No	Yes	1	1	4
337	E:E:C40	E:E:L69	3.17	No	No	0	9	8
338	E:E:C40	E:E:C72	7.28	No	No	0	9	9
339	E:E:F92	E:E:L41	8.53	Yes	No	0	5	5
340	E:E:Q43	E:E:T42	5.67	No	No	0	2	1
341	E:E:D47	E:E:Q43	5.22	No	No	0	4	2
342	E:E:F44	E:E:L69	9.74	No	No	0	9	8
343	E:E:F44	E:E:Y100	13.41	No	No	0	9	7
344	E:E:D47	E:E:E68	10.39	No	No	0	4	3
345	E:E:M48	E:E:W56	4.65	No	Yes	0	9	5
346	E:E:M48	E:E:T62	3.01	No	No	0	9	8
347	E:E:R61	E:E:V51	13.08	No	No	0	4	5
348	E:E:E53	E:E:W56	11.99	No	Yes	0	3	5
349	E:E:D58	E:E:L55	8.14	No	No	0	6	5
350	E:E:W56	E:E:Y100	10.61	Yes	No	0	5	7
351	E:E:C104	E:E:C57	7.28	No	No	2	9	9
352	E:E:C57	E:E:P105	3.77	No	No	2	9	7
353	E:E:D58	E:E:R61	7.15	No	No	0	6	4
354	E:E:T62	E:E:W59	3.64	No	Yes	0	8	7
355	E:E:I63	E:E:W59	16.44	No	Yes	0	5	7
356	E:E:W59	E:E:Y66	6.75	Yes	Yes	2	7	9
357	E:E:R109	E:E:W59	12	Yes	Yes	2	5	7
358	E:E:R64	E:E:R67	9.6	No	No	0	5	5
359	E:E:H97	E:E:Y66	6.53	Yes	Yes	2	9	9
360	E:E:E68	E:E:L69	5.3	No	No	0	3	8
361	E:E:T73	E:E:W84	12.13	No	Yes	1	8	7
362	E:E:T73	E:E:V89	4.76	No	Yes	1	8	8
363	E:E:E78	E:E:W74	18.54	No	No	0	3	7
364	E:E:W74	E:E:W84	11.25	No	Yes	1	7	7
365	E:E:K79	E:E:M76	8.64	No	Yes	1	1	4
366	E:E:A77	E:E:W84	3.89	No	Yes	0	8	7
367	E:E:P85	E:E:W84	10.81	No	Yes	1	9	7
368	E:E:V89	E:E:W84	4.9	Yes	Yes	1	8	7
369	E:E:P85	E:E:V89	3.53	No	Yes	1	9	8
370	E:E:E88	E:E:N86	3.94	Yes	No	1	4	9
371	E:E:N86	E:E:V89	4.43	No	Yes	1	9	8
372	E:E:E88	E:E:R91	11.63	Yes	No	0	4	3
373	E:E:F92	E:E:F93	7.5	Yes	No	0	5	9
374	E:E:F92	E:E:V96	5.24	Yes	No	0	5	7
375	E:E:R99	E:E:V96	7.85	No	No	0	2	7
376	E:E:F101	E:E:H97	13.58	No	Yes	2	9	9
377	E:E:G98	E:E:R102	3	No	No	0	5	5
378	E:E:R99	E:E:Y100	19.55	No	No	0	2	7
379	E:E:C104	E:E:P105	3.77	No	No	2	9	7
380	E:E:P105	E:E:R109	4.32	No	Yes	2	7	5
381	E:E:I106	E:E:S107	3.1	No	No	0	4	5
382	E:E:D113	E:E:P114	4.83	Yes	Yes	0	9	9
383	E:E:L119	E:E:P114	8.21	No	Yes	0	8	9
384	E:E:P126	E:E:V125	3.53	No	No	0	9	7
385	E:E:K142	E:E:W139	9.28	No	No	0	8	6
386	E:E:Q140	E:E:R143	7.01	No	No	18	7	8
387	R:R:I146	R:R:I192	2.94	No	No	0	6	6
388	R:R:I340	R:R:I383	2.94	No	No	0	8	7
389	E:E:D47	E:E:S65	2.94	No	No	0	4	5
390	R:R:I241	R:R:L237	2.85	No	No	0	8	9
391	R:R:I312	R:R:L237	2.85	No	No	0	9	9
392	R:R:Q172	R:R:T175	2.83	Yes	No	0	7	6
393	R:R:K178	R:R:L160	2.82	No	No	0	6	5
394	R:R:D96	R:R:K134	2.77	No	No	0	5	3
395	R:R:A301	R:R:F228	2.77	No	Yes	0	7	5
396	E:E:F122	R:R:A273	2.77	No	No	0	8	5
397	R:R:A337	R:R:F384	2.77	No	Yes	0	9	8
398	R:R:L341	R:R:L379	2.77	Yes	No	0	9	5
399	R:R:E348	R:R:M369	2.71	Yes	No	0	8	8
400	R:R:E133	R:R:K134	2.7	No	No	0	1	3
401	R:R:D77	R:R:N66	2.69	No	No	0	4	5
402	R:R:A44	R:R:Y91	2.67	No	Yes	0	6	5
403	E:E:L136	E:E:Q140	2.66	No	No	0	8	7
404	R:R:H238	R:R:I312	2.65	Yes	No	0	8	9
405	R:R:F181	R:R:V380	2.62	No	Yes	0	8	9
406	R:R:A271	R:R:W283	2.59	No	Yes	0	5	8
407	R:R:F386	R:R:T382	2.59	No	No	0	8	5
408	R:R:F246	R:R:I241	2.51	No	No	0	6	8
409	R:R:F163	R:R:K178	2.48	Yes	No	0	7	6
410	R:R:M332	R:R:R336	2.48	No	No	0	6	8
411	E:E:S103	E:E:W56	2.47	No	Yes	0	7	5
412	R:R:F142	R:R:L195	2.44	Yes	No	0	6	7
413	R:R:T120	R:R:W111	2.43	No	Yes	0	5	9
414	R:R:L395	R:R:R396	2.43	No	Yes	0	5	5
415	E:E:I123	R:R:Y292	2.42	No	No	0	9	6
416	E:E:R67	R:R:N39	2.41	No	No	0	5	5
417	E:E:D71	E:E:R67	2.38	No	No	0	3	5
418	E:E:L80	E:E:Y32	2.34	No	Yes	0	5	6
419	E:E:F44	E:E:Q45	2.34	No	No	0	9	4
420	E:E:F122	R:R:Y277	2.06	No	Yes	0	8	3
421	R:R:G261	R:R:P263	2.03	No	Yes	0	7	9
422	E:E:G116	E:E:P115	2.03	No	No	0	5	9
423	R:R:C105	R:R:G81	1.96	No	No	0	9	7
424	R:R:C299	R:R:G296	1.96	No	No	0	4	4
425	E:E:P126	R:R:P297	1.95	No	No	0	9	8
426	E:E:P114	E:E:P115	1.95	Yes	No	0	9	9
427	E:E:G108	E:E:S107	1.86	No	No	0	5	5
428	R:R:G377	R:R:V380	1.84	No	Yes	0	9	9
429	R:R:A244	R:R:A247	1.79	No	No	0	6	6
430	E:E:T130	R:R:P297	1.75	Yes	No	0	9	8
431	R:R:G234	R:R:L237	1.71	No	No	0	8	9
432	E:E:G52	E:E:L55	1.71	No	No	0	5	5
433	R:R:G35	R:R:N39	1.7	No	No	0	2	5
434	R:R:G389	R:R:N388	1.7	No	No	0	6	9
435	L:L:G7	L:L:N5	1.7	No	No	0	0	0
436	R:R:I294	R:R:P266	1.69	No	No	0	7	6
437	E:E:P126	R:R:I269	1.69	No	No	0	9	5
438	E:E:A110	R:R:T43	1.68	No	No	0	4	5
439	R:R:A79	R:R:T82	1.68	No	No	0	1	5
440	E:E:T130	R:R:A300	1.68	Yes	No	0	9	3
441	E:E:D58	E:E:G60	1.68	No	No	0	6	5
442	E:E:G108	R:R:E47	1.64	No	Yes	0	5	6
443	R:R:L204	R:R:P209	1.64	No	Yes	0	4	5
444	R:R:G389	R:R:Q392	1.64	No	No	0	6	7
445	L:L:P3	R:R:N128	1.63	No	No	0	0	3
446	R:R:D96	R:R:P97	1.61	No	No	0	5	3
447	R:R:V242	R:R:V315	1.6	No	Yes	0	6	8
448	R:R:V313	R:R:V335	1.6	No	No	0	6	8
449	E:E:V125	E:E:V129	1.6	No	No	0	7	8
450	E:E:V129	E:E:V133	1.6	No	No	0	8	7
451	R:R:T37	R:R:V36	1.59	No	No	0	4	2
452	R:R:T191	R:R:V190	1.59	No	No	0	7	6
453	R:R:C299	R:R:L303	1.59	No	No	0	4	3
454	E:E:T134	R:R:V304	1.59	No	No	0	8	6
455	R:R:T318	R:R:V315	1.59	No	Yes	0	7	8
456	E:E:T62	E:E:V51	1.59	No	No	0	8	5
457	E:E:T128	E:E:V124	1.59	No	No	0	6	6
458	E:E:T128	E:E:V129	1.59	No	No	0	6	8
459	R:R:A138	R:R:L139	1.58	No	No	0	5	3
460	E:E:I118	E:E:S117	1.55	No	No	0	6	5
461	R:R:I347	R:R:V350	1.54	No	No	0	7	6
462	R:R:I104	R:R:T102	1.52	No	No	0	4	5
463	E:E:K142	R:R:V243	1.52	No	No	0	8	5
464	R:R:K319	R:R:V315	1.52	No	Yes	0	9	8
465	R:R:M85	R:R:T102	1.51	No	No	0	4	5
466	E:E:A50	E:E:E49	1.51	No	No	0	4	2
467	R:R:L310	R:R:V313	1.49	No	No	0	5	6
468	R:R:L316	R:R:V315	1.49	No	Yes	0	8	8
469	E:E:L55	E:E:T54	1.47	No	No	0	5	3
470	E:E:L131	E:E:T130	1.47	No	Yes	0	8	9
471	R:R:N200	R:R:T196	1.46	No	No	0	3	3
472	E:E:V111	R:R:D280	1.46	No	No	0	4	4
473	R:R:D94	R:R:T131	1.45	Yes	No	0	5	1
474	E:E:G116	E:E:Y120	1.45	No	No	0	5	5
475	R:R:K333	R:R:M332	1.44	No	No	0	8	6
476	R:R:Q126	R:R:V129	1.43	No	No	0	5	2
477	R:R:I174	R:R:L169	1.43	No	No	0	9	9
478	R:R:I394	R:R:L169	1.43	No	No	0	8	9
479	E:E:P121	E:E:Y120	1.39	No	No	0	6	5
480	E:E:A34	E:E:R37	1.38	No	No	0	2	4
481	E:E:A95	E:E:R99	1.38	No	No	0	3	2
482	R:R:E83	R:R:I104	1.37	No	No	0	3	4
483	R:R:K249	R:R:Q172	1.36	No	Yes	0	5	7
484	E:E:H75	E:E:M76	1.31	No	Yes	1	1	4
485	E:E:H75	E:E:K79	1.31	No	No	1	1	1
486	R:R:F386	R:R:I158	1.26	No	No	0	8	5
487	R:R:I340	R:R:R336	1.25	No	No	0	8	8
488	L:L:K9	R:R:R119	1.24	No	No	0	0	4
489	R:R:F217	R:R:L264	1.22	No	No	0	6	3
490	R:R:L34	R:R:R38	1.21	No	No	0	2	5
491	R:R:F166	R:R:N398	1.21	No	No	0	7	5
492	R:R:N400	R:R:R396	1.21	No	Yes	20	4	5
493	R:R:N400	R:R:R397	1.21	No	No	20	4	7
494	R:R:Q392	R:R:R396	1.17	No	Yes	0	7	5
495	R:R:Q401	R:R:Y402	1.13	No	No	0	6	3
496	R:R:E363	R:R:W354	1.09	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q45	7.422	5	0	5
2	R:R:Y46	10.12	6	2	2
3	R:R:E47	5.425	4	2	6
4	R:R:Y49	9.015	4	0	3
5	R:R:Q50	9.1625	4	2	4
6	R:R:W69	10.685	4	0	7
7	R:R:W72	8.468	5	1	5
8	R:R:L73	6.34	5	7	5
9	R:R:W75	12.1917	6	7	9
10	R:R:V78	4.17	4	0	7
11	R:R:C88	6.44	4	1	9
12	R:R:Y91	8.41833	6	1	5
13	R:R:F92	9.05	5	1	6
14	R:R:D94	7.54	6	1	5
15	R:R:F95	8.28667	6	1	5
16	R:R:W111	10.53	5	0	9
17	R:R:H114	9.218	5	9	4
18	R:R:Y124	9.255	4	0	4
19	R:R:L141	10.6025	4	11	6
20	R:R:F142	4.52	4	0	6
21	R:R:F163	6.0425	4	0	7
22	R:R:Q172	6.032	5	4	7
23	R:R:P209	3.248	5	3	5
24	R:R:C212	4.435	4	3	9
25	R:R:Y221	6.022	5	5	8
26	R:R:L222	3.8925	4	5	5
27	R:R:F228	6.105	4	5	5
28	R:R:W229	8.02	5	0	9
29	R:R:L231	5.29	4	0	8
30	R:R:I235	5.2325	4	0	6
31	R:R:Y236	8.594	5	4	8
32	R:R:H238	6.8275	4	0	8
33	R:R:Q250	6.996	5	4	6
34	R:R:Y255	5.41143	7	4	8
35	R:R:F262	7.828	5	5	4
36	R:R:P263	4.85	5	5	9
37	R:R:H270	8.305	4	15	8
38	R:R:Y277	4.99	4	0	3
39	R:R:Y278	10.648	5	6	6
40	R:R:C282	4.7625	4	3	9
41	R:R:W283	9.954	5	3	8
42	R:R:T288	7.1825	4	6	5
43	R:R:V315	1.55	4	0	8
44	R:R:L341	5.1475	4	13	9
45	R:R:E348	6.745	4	0	8
46	R:R:F349	7.3175	4	16	8
47	R:R:H374	10.925	4	0	9
48	R:R:F375	5.778	5	12	7
49	R:R:L378	4.925	4	0	6
50	R:R:V380	4.615	4	0	9
51	R:R:F384	7.544	5	13	8
52	R:R:R396	2.0025	4	20	5
53	L:L:F11	4.2625	4	1	0
54	E:E:Y32	4.12	7	1	6
55	E:E:L36	4.28	4	1	5
56	E:E:W56	7.43	4	0	5
57	E:E:W59	8.365	6	2	7
58	E:E:Y66	7.245	4	2	9
59	E:E:M76	4.445	4	1	4
60	E:E:W84	7.665	6	1	7
61	E:E:E88	6.525	4	1	4
62	E:E:V89	4.282	5	1	8
63	E:E:F92	6.23	4	0	5
64	E:E:H97	9.4425	4	2	9
65	E:E:R109	10.0425	4	2	5
66	E:E:D113	6.4075	4	6	9
67	E:E:P114	5.8325	4	0	9
68	E:E:T130	2.5225	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F11	R:R:W72	64.3826	8.02	Yes	Yes	1	0	5
2	L:L:F11	R:R:G71	53.2471	3.01	Yes	No	0	0	4
3	R:R:G71	R:R:W69	53.1844	9.85	No	Yes	0	4	7
4	R:R:Q45	R:R:W69	35.8009	13.14	Yes	Yes	0	5	7
5	E:E:Y66	R:R:Q45	30.1481	6.76	Yes	Yes	0	9	5
6	E:E:W59	E:E:Y66	22.7096	6.75	Yes	Yes	2	7	9
7	E:E:F93	R:R:Q45	12.42	5.86	No	Yes	0	9	5
8	R:R:C48	R:R:W69	11.3637	9.14	No	Yes	0	9	7
9	E:E:H97	R:R:Y49	13.6598	6.53	Yes	Yes	0	9	3
10	E:E:D90	R:R:Y49	10.1419	3.45	No	Yes	0	8	3
11	E:E:G108	R:R:E47	13.624	1.64	No	Yes	0	5	6
12	E:E:G108	E:E:S107	11.7039	1.86	No	No	0	5	5
13	R:R:W72	R:R:Y124	13.1003	14.47	Yes	Yes	0	5	4
14	R:R:F95	R:R:W72	45.5937	6.01	Yes	Yes	1	5	5
15	R:R:F112	R:R:H114	10.3612	6.79	No	Yes	0	5	4
16	R:R:H114	R:R:W121	22.0472	14.81	Yes	No	0	4	8
17	R:R:N123	R:R:W121	23.6808	9.04	No	No	0	8	8
18	R:R:N123	R:R:Q126	25.2383	6.6	No	No	10	8	5
19	R:R:Q126	R:R:V129	28.528	1.43	No	No	0	5	2
20	R:R:N130	R:R:V129	30.1258	8.87	No	No	0	2	2
21	R:R:E133	R:R:N130	31.7146	11.83	No	No	0	1	2
22	R:R:E133	R:R:K134	33.2945	2.7	No	No	0	1	3
23	R:R:D96	R:R:K134	34.8655	2.77	No	No	0	5	3
24	R:R:D96	R:R:E99	39.5247	6.5	No	No	0	5	5
25	R:R:C88	R:R:E99	22.1501	9.12	Yes	No	1	9	5
26	R:R:C88	R:R:F95	20.0868	5.59	Yes	Yes	1	9	5
27	R:R:C127	R:R:E99	18.9052	3.04	No	No	1	9	5
28	R:R:C127	R:R:F95	19.6303	13.97	No	Yes	1	9	5
29	R:R:D94	R:R:F95	10.1061	7.17	Yes	Yes	1	5	5
30	E:E:W84	L:L:F11	34.1986	3.01	Yes	Yes	1	7	0
31	E:E:T73	E:E:W84	10.0076	12.13	No	Yes	1	8	7
32	E:E:A77	E:E:W84	10.0121	3.89	No	Yes	0	8	7
33	E:E:V89	E:E:W84	13.3465	4.9	Yes	Yes	1	8	7
34	E:E:F92	E:E:F93	23.0542	7.5	Yes	No	0	5	9
35	E:E:M76	E:E:Y32	17.4507	3.59	Yes	Yes	1	4	6
36	E:E:F44	E:E:L69	11.131	9.74	No	No	0	9	8
37	E:E:F44	E:E:Y100	13.8254	13.41	No	No	0	9	7
38	E:E:T62	E:E:W59	13.0734	3.64	No	Yes	0	8	7
39	E:E:F92	E:E:V96	17.1329	5.24	Yes	No	0	5	7
40	E:E:R99	E:E:Y100	13.9417	19.55	No	No	0	2	7
41	E:E:F93	R:R:Y49	12.1515	15.47	No	Yes	0	9	3
42	R:R:W69	R:R:Y49	17.209	10.61	Yes	Yes	0	7	3
43	E:E:Y66	R:R:Y46	10.2045	8.94	Yes	Yes	2	9	2
44	E:E:R99	E:E:V96	15.92	7.85	No	No	0	2	7
45	R:R:H374	R:R:T145	14.1387	20.54	Yes	No	0	9	7
46	R:R:L195	R:R:T145	12.7646	4.42	No	No	0	7	7
47	R:R:F142	R:R:L195	11.3816	2.44	Yes	No	0	6	7
48	R:R:L378	R:R:S152	20.1898	7.51	Yes	No	0	6	9
49	R:R:G377	R:R:S152	21.8144	3.71	No	No	0	9	9
50	R:R:G377	R:R:V380	23.4302	1.84	No	Yes	0	9	9
51	R:R:F184	R:R:V380	71.3467	6.55	No	Yes	0	8	9
52	R:R:F184	R:R:N226	71.8391	12.08	No	No	14	8	8
53	R:R:N187	R:R:N226	74.2425	13.62	No	No	0	8	8
54	R:R:L222	R:R:N187	75.5091	4.12	Yes	No	0	5	8
55	R:R:L222	R:R:Y221	39.7485	3.52	Yes	Yes	5	5	8
56	R:R:P263	R:R:Y221	42.3444	8.34	Yes	Yes	5	9	8
57	R:R:F228	R:R:P263	61.7598	5.78	Yes	Yes	5	5	9
58	R:R:F228	R:R:G224	100	3.01	Yes	No	0	5	5
59	R:R:G224	R:R:I298	99.4137	3.53	No	No	0	5	7
60	R:R:F349	R:R:I298	95.7302	3.77	Yes	No	16	8	7
61	R:R:E348	R:R:F349	50.0918	9.33	Yes	Yes	0	8	8
62	R:R:E348	R:R:M373	37.3406	9.47	Yes	No	0	8	7
63	R:R:H374	R:R:M373	36.1276	5.25	Yes	No	0	9	7
64	R:R:C225	R:R:L222	38.4774	3.17	No	Yes	5	8	5
65	R:R:C225	R:R:P263	38.9966	3.77	No	Yes	5	8	9
66	R:R:H149	R:R:H374	12.7646	8.36	No	Yes	0	7	9
67	R:R:F181	R:R:V380	45.0879	2.62	No	Yes	0	8	9
68	R:R:F163	R:R:F181	35.5771	5.36	Yes	No	0	7	8
69	R:R:F163	R:R:I162	18.5069	6.28	Yes	No	0	7	8
70	R:R:I162	R:R:V391	16.9136	3.07	No	No	0	8	9
71	R:R:F163	R:R:I174	11.9321	10.05	Yes	No	0	7	9
72	R:R:F228	R:R:F262	39.3815	12.86	Yes	Yes	5	5	4
73	R:R:F262	R:R:L258	44.0585	3.65	Yes	No	0	4	6
74	R:R:L231	R:R:L258	42.6979	5.54	Yes	No	0	8	6
75	R:R:I235	R:R:L231	40.7644	4.28	Yes	Yes	0	6	8
76	R:R:I235	R:R:Y255	36.0381	6.04	Yes	Yes	0	6	8
77	R:R:Y236	R:R:Y255	17.746	4.96	Yes	Yes	4	8	8
78	R:R:L252	R:R:Y255	10.1866	5.86	No	Yes	0	6	8
79	R:R:E233	R:R:H177	18.7665	7.39	No	No	0	9	9
80	R:R:E233	R:R:L176	20.2569	7.95	No	No	0	9	9
81	R:R:L176	R:R:Y236	16.56	5.86	No	Yes	0	9	8
82	R:R:F384	R:R:L341	23.9314	6.09	Yes	Yes	13	8	9
83	R:R:L341	R:R:V380	33.8361	7.45	Yes	Yes	0	9	9
84	R:R:H270	R:R:R274	15.0517	13.54	Yes	No	0	8	7
85	R:R:L290	R:R:R274	37.3406	3.64	No	No	0	3	7
86	R:R:L290	R:R:T288	38.5445	2.95	No	Yes	0	3	5
87	R:R:L291	R:R:T288	62.7669	4.42	No	Yes	0	5	5
88	R:R:H295	R:R:L291	63.7649	3.86	No	No	0	6	5
89	R:R:F349	R:R:H295	64.7541	7.92	Yes	No	0	8	6
90	R:R:R274	R:R:W283	21.7428	16.99	No	Yes	0	7	8
91	R:R:K213	R:R:W283	16.4973	18.57	No	Yes	3	8	8
92	R:R:C282	R:R:K213	11.0191	4.85	Yes	No	3	9	8
93	R:R:F308	R:R:I235	22.1949	7.54	No	Yes	0	8	6
94	R:R:F308	R:R:H238	20.1361	13.58	No	Yes	0	8	8
95	R:R:H238	R:R:I312	10.4283	2.65	Yes	No	0	8	9
96	E:E:T130	R:R:F262	21.1878	5.19	Yes	Yes	0	9	4
97	E:E:D113	R:R:T288	21.8368	10.12	Yes	Yes	6	9	5
98	E:E:D113	E:E:P114	16.8599	4.83	Yes	Yes	0	9	9
99	R:R:G296	R:R:P297	11.6681	4.06	No	No	0	4	8
100	E:E:T130	R:R:P297	15.7096	1.75	Yes	No	0	9	8
101	R:R:C299	R:R:G296	10.2403	1.96	No	No	0	4	4
102	R:R:F384	R:R:T338	10.5492	6.49	Yes	No	0	8	9
103	R:R:E348	R:R:M369	11.3816	2.71	Yes	No	0	8	8
104	R:R:N388	R:R:V391	15.2621	8.87	No	No	0	9	9
105	R:R:G389	R:R:N388	11.9321	1.7	No	No	0	6	9
106	R:R:G389	R:R:Q392	10.2538	1.64	No	No	0	6	7
107	R:R:F384	R:R:H177	17.3388	13.58	Yes	No	0	8	9
108	R:R:F262	R:R:P263	19.9928	4.33	Yes	Yes	5	4	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G71	R:R:W69	9.85	0	No	Yes	4	7	1	2
L:L:F11	R:R:G71	3.01	1	Yes	No	0	4	0	1
R:R:W72	R:R:Y91	4.82	1	Yes	Yes	5	5	1	2
R:R:F92	R:R:W72	9.02	1	Yes	Yes	6	5	1	1
R:R:F95	R:R:W72	6.01	1	Yes	Yes	5	5	1	1
R:R:W72	R:R:Y124	14.47	1	Yes	Yes	5	4	1	2
L:L:F11	R:R:W72	8.02	1	Yes	Yes	0	5	0	1
R:R:C88	R:R:F95	5.59	1	Yes	Yes	9	5	2	1
R:R:C127	R:R:C88	7.28	1	No	Yes	9	9	2	2
R:R:F92	R:R:Y91	9.28	1	Yes	Yes	6	5	1	2
R:R:D94	R:R:F92	4.78	1	Yes	Yes	5	6	1	1
R:R:F92	R:R:F95	11.79	1	Yes	Yes	6	5	1	1
L:L:T4	R:R:F92	10.38	1	No	Yes	0	6	0	1
L:L:F1	R:R:Q93	10.54	0	No	No	0	4	0	1
R:R:D94	R:R:F95	7.17	1	Yes	Yes	5	5	1	1
R:R:D94	R:R:N128	8.08	1	Yes	No	5	3	1	1
L:L:F1	R:R:D94	10.75	0	No	Yes	0	5	0	1
L:L:T4	R:R:D94	13.01	1	No	Yes	0	5	0	1
R:R:C127	R:R:F95	13.97	1	No	Yes	9	5	2	1
L:L:T4	R:R:F95	5.19	1	No	Yes	0	5	0	1
R:R:F112	R:R:H114	6.79	0	No	Yes	5	4	2	1
R:R:H114	R:R:P115	9.15	9	Yes	No	4	3	1	2
R:R:H114	R:R:S117	6.97	9	Yes	No	4	4	1	1
R:R:H114	R:R:W121	14.81	9	Yes	No	4	8	1	2
L:L:S8	R:R:H114	8.37	9	No	Yes	0	4	0	1
R:R:R119	R:R:S117	5.27	0	No	No	4	4	1	1
L:L:S8	R:R:S117	6.52	9	No	No	0	4	0	1
E:E:F83	R:R:R119	19.24	0	No	No	5	4	2	1
L:L:V6	R:R:N128	11.82	0	No	No	0	3	0	1
E:E:W74	L:L:F11	3.01	1	No	Yes	7	0	1	0
E:E:W84	L:L:F11	3.01	1	Yes	Yes	7	0	1	0
E:E:T73	E:E:W84	12.13	1	No	Yes	8	7	2	1
E:E:T73	E:E:V89	4.76	1	No	Yes	8	8	2	2
E:E:E78	E:E:W74	18.54	0	No	No	3	7	2	1
E:E:W74	E:E:W84	11.25	1	No	Yes	7	7	1	1
E:E:A77	E:E:W84	3.89	0	No	Yes	8	7	2	1
E:E:P85	E:E:W84	10.81	1	No	Yes	9	7	2	1
E:E:V89	E:E:W84	4.9	1	Yes	Yes	8	7	2	1
E:E:P85	E:E:V89	3.53	1	No	Yes	9	8	2	2
L:L:P3	R:R:N128	1.63	0	No	No	0	3	0	1
R:R:D94	R:R:T131	1.45	1	Yes	No	5	1	1	2
L:L:K9	R:R:R119	1.24	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
33.33	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
33.33	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
33.33	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
33.33	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
33.33	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
33.33	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
33.33	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042
33.33	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
33.33	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
33.33	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
33.33	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
33.33	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626
33.33	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
33.33	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
33.33	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
33.33	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
33.33	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
33.33	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
33.33	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
33.33	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
33.33	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
33.33	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
33.33	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
33.33	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
33.33	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
33.33	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
33.33	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
33.33	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
33.33	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
33.33	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
33.33	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
33.33	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
33.33	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
33.33	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
33.33	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
33.33	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
33.33	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
33.33	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
33.33	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
33.33	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
33.33	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
33.33	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
33.33	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
33.33	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
33.33	Single	7XW7	K1-70	7XW7-TSH-K1-70
33.33	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
33.33	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
33.33	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
33.33	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
33.33	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
33.33	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
33.33	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
33.33	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
33.33	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
33.33	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
33.33	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
33.33	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
33.33	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
33.33	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
33.33	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
33.33	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
33.33	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
33.33	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
33.33	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
33.33	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
33.33	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
33.33	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
33.33	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
33.33	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
33.33	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
33.33	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
33.33	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
33.33	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
33.33	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
33.33	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
33.33	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
33.33	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
33.33	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
33.33	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
33.33	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
33.33	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
33.33	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
33.33	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
33.33	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
33.33	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
33.33	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
33.33	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
33.33	Single	8WG9	(2S)-2-amino-4-phosphonobutanoic acid	8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
33.33	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
33.33	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
33.33	Single	8WGC	LY379268	8WGC-mGlu4; mGlu2-LY379268
33.33	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
33.33	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
33.33	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33	Single	8WVX	Norrin	8WVX-LGR4-Norrin
33.33	Single	8WVY	Norrin	8WVY-LGR4-Norrin
33.33	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
33.33	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
33.33	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
33.33	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
33.33	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
33.33	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
33.33	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
33.33	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
33.33	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
33.33	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
33.33	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
33.33	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
33.33	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
33.33	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
33.33	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
33.33	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
33.33	Single	9KHH	Norrin	9KHH-LGR4-Norrin
33.33	Single	9S37	NB21	9S37-LGR4-NB21
33.33	Single	9UTB	Sucralose	9UTB-TAS1R2; TAS1R3-Sucralose
25.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
25.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
25.00	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
16.67	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
16.67	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
16.67	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
16.67	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
14.29	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
14.29	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
14.29	Single	8HS2	Fab046	8HS2-GPR20-Fab046
14.29	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
14.29	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
12.50	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
12.50	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
11.11	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
11.11	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
11.11	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.11	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
11.11	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
11.11	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
10.00	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
10.00	Single	6LI0	C17	6LI0-GPR52-C17
10.00	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
10.00	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
10.00	Single	9B9Y	7DY	9B9Y-CB₁-7DY
10.00	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
9.09	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
9.09	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
9.09	Single	5U09	Taranabant	5U09-CB₁-Taranabant
9.09	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
9.09	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
9.09	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
9.09	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
9.09	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
9.09	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.09	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
9.09	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
9.09	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
9.09	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
9.09	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
9.09	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
9.09	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
9.09	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
9.09	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
9.09	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
8.33	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
8.33	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.33	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
8.33	Single	7UTZ	DPPC	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
8.33	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
8.33	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
8.33	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
8.33	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
8.33	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
8.33	Single	9M2F	Neuropeptide FF	9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
8.33	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
8.33	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
8.33	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
8.33	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.69	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
7.69	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
7.69	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
7.69	Single	6D27	CAY10471	6D27-DP₂-CAY10471
7.69	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
7.69	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
7.69	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
7.69	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.69	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
7.69	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
7.69	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
7.69	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
7.69	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
7.69	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
7.69	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
7.69	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
7.69	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
7.69	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
7.69	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
7.69	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
7.41	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.14	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
7.14	Single	5C1M	BU72	5C1M-μ-BU72
7.14	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
7.14	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
7.14	Single	7C4S	S1P	7C4S-S1P₃-S1P
7.14	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
7.14	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
7.14	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
7.14	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
7.14	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
7.14	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
7.14	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	8ZYT	Neurotensin peptide 8-13	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
7.14	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
7.14	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
7.14	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
7.14	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
7.14	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
7.14	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
6.67	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
6.67	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
6.67	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
6.67	Single	5V56	TC114	5V56-SMO-TC114
6.67	Single	5V57	TC114	5V57-SMO-TC114
6.67	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.67	Single	6OS1	TRV026	6OS1-AT₁-TRV026
6.67	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
6.67	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
6.67	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
6.67	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
6.67	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
6.67	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
6.67	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
6.67	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
6.67	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
6.67	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
6.67	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
6.67	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
6.67	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
6.67	Single	8E0G	BU72	8E0G-μ-BU72
6.67	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
6.67	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
6.67	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
6.67	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
6.67	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
6.67	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
6.67	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
6.67	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
6.67	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
6.67	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
6.67	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
6.67	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
6.67	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
6.67	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
6.67	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
6.67	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
6.67	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
6.67	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
6.25	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
6.25	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
6.25	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
6.25	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
6.25	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
6.25	Single	6OS2	TRV026	6OS2-AT₁-TRV026
6.25	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
6.25	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
6.25	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
6.25	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
6.25	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
6.25	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
6.25	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
6.25	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
6.25	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
6.25	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
6.25	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
6.25	Single	8XQJ	JN241	8XQJ-Apelin-JN241
6.25	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
6.25	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
6.25	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
6.25	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
6.25	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
6.25	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
6.25	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
6.25	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
6.25	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
6.25	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
6.25	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
6.25	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
6.25	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
6.25	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
6.25	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
6.25	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
6.25	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
6.25	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
6.25	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
6.25	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
5.88	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
5.88	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
5.88	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
5.88	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
5.88	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
5.88	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
5.88	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
5.88	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
5.88	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
5.88	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
5.88	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
5.88	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
5.88	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
5.88	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-SBI-553
5.88	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
5.88	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
5.88	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
5.88	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
5.88	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
5.88	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.88	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
5.88	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.88	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
5.88	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
5.88	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.88	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
5.56	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
5.56	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
5.56	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
5.56	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
5.56	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
5.56	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
5.56	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
5.56	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
5.56	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
5.56	Single	8XQJ	JN241	8XQJ-Apelin-JN241
5.56	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
5.56	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.56	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
5.56	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
5.56	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
5.56	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
5.26	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.26	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
5.26	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
5.26	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
5.26	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.26	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
5.26	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
5.26	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.26	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.26	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
5.26	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
5.26	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
5.26	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
5.26	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
5.26	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
5.26	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.26	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
5.26	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.26	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.26	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
5.26	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
5.26	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
5.26	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
5.00	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
5.00	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.00	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.00	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.00	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.00	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
5.00	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
5.00	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
5.00	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.00	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
5.00	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.00	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.00	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
5.00	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.00	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
5.00	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
5.00	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
4.76	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
4.76	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
4.76	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
4.76	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.76	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
4.76	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
4.76	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
4.76	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
4.76	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
4.76	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
4.76	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
4.76	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.76	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
4.76	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
4.76	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
4.76	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
4.76	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
4.76	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
4.76	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
4.76	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
4.76	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
4.76	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.76	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.55	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
4.55	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.55	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
4.55	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
4.55	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
4.55	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
4.55	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
4.55	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
4.55	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3
4.55	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
4.55	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
4.55	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
4.55	Single	9BLC	Cagrilintide backbone (non-acylated)	9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
4.55	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
4.55	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
4.55	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
4.55	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
4.55	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
4.55	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.55	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
4.55	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
4.55	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
4.55	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
4.55	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
4.55	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
4.55	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
4.55	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
4.55	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
4.55	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
4.35	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.35	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
4.35	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
4.35	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
4.35	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.35	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.35	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.35	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.35	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.35	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
4.35	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.35	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.35	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
4.35	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
4.35	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
4.35	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
4.35	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.35	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
4.35	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.35	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.35	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.35	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9JFY	hNPSF	9JFY-NPFF2-hNPSF-Gi1/β1/γ2
4.35	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
4.35	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.35	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
4.35	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
4.35	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
4.35	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.35	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.35	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
4.35	Consensus	pac_on	Orthosteric Ligand	pac1_on
4.35	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
4.35	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
4.17	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.17	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.17	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.17	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.17	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.17	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.17	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.17	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.17	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.17	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
4.17	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.17	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.17	Single	9BLB	Cagrilintide backbone (non-acylated)	9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
4.17	Single	9BLW	Cagrilintide backbone (non-acylated)	9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
4.17	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
4.17	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
4.17	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.17	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
4.17	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.17	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.17	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
4.17	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
4.17	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
4.17	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.17	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.17	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.17	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
4.17	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
4.17	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
4.17	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
4.17	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
4.17	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
4.00	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.00	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.00	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.00	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.00	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
4.00	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
4.00	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.00	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
4.00	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
4.00	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
4.00	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.00	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.00	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.00	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3
4.00	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.00	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.00	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
4.00	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
4.00	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.00	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
4.00	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
4.00	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
4.00	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
4.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.00	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.00	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.00	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.00	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
3.85	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
3.85	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.85	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.85	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.85	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.85	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
3.85	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
3.85	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.85	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.85	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
3.85	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.85	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
3.85	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
3.85	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
3.85	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
3.85	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
3.85	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
3.85	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
3.85	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
3.85	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
3.85	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
3.85	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
3.85	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
3.85	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
3.85	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.85	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
3.85	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
3.85	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
3.85	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
3.70	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.70	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.70	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
3.70	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
3.70	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
3.70	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.70	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
3.70	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.70	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.70	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.70	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
3.70	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
3.57	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
3.57	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.57	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.57	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.57	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.57	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.57	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.57	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
3.57	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.57	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
3.57	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.45	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.45	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.45	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.45	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
3.45	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.45	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.45	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
3.45	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.45	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.33	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
3.33	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.33	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
3.33	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.33	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
3.33	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.33	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
3.33	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.33	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
3.33	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
3.33	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
3.23	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.23	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
3.23	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.12	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.12	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.12	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.03	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
3.03	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
3.03	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
2.94	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.86	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.86	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
2.70	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
2.63	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	7KNU
Class	B1
SubFamily	Peptide
Type	Calcitonin
SubType	CT Like
Species	Homo Sapiens
Ligand	Calcitonin gene-related peptide-1
Other Ligand(s)	-
Protein Partners	RAMP1
PDB Resolution	3.49
Date	2021-02-24
D.O.I.	doi.org/10.1126/science.abf7258

Net Summary
I_min	2.95
Number of Linked Nodes	432
Number of Links	496
Number of Hubs	68
Number of Links mediated by Hubs	252
Number of Communities	20
Number of Nodes involved in Communities	107
Number of Links involved in Communities	139

Path Summary
Number Of Nodes in MetaPath	109
Number Of Links MetaPath	108
Number of Shortest Paths	70376
Length Of Smallest Path	3
Average Path Length	14.5258
Length of Longest Path	33
Minimum Path Strength	1.19
Average Path Strength	6.50639
Maximum Path Strength	24.23
Minimum Path Correlation	0.7
Average Path Correlation	0.964032
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	65.8248
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.983
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • calcitonin family binding • amide binding • binding • adrenomedullin binding • peptide hormone binding • hormone binding • adrenomedullin receptor activity • calcitonin gene-related peptide receptor activity • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis
Gene Ontology	Biological Process	• developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • establishment of protein localization • nitrogen compound transport • protein transport • macromolecule localization • intracellular protein localization • regulation of vascular associated smooth muscle cell proliferation • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • response to disaccharide • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to sucrose stimulus • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • response to carbohydrate • response to sucrose • response to chemical • cellular response to disaccharide stimulus • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • membrane-bounded organelle • intracellular organelle • organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • vesicle • CGRP receptor complex • endoplasmic reticulum • protein binding • binding • signaling receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • protein-containing complex binding • cell population proliferation • endothelial cell proliferation • cellular process • epithelial cell proliferation • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • regulation of cellular process • interleukin-1 production • positive regulation of biological process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of interleukin-1 alpha production • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of interleukin-1 production • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of biosynthetic process • regulation of biological process • regulation of interleukin-1 production • regulation of macromolecule metabolic process • gene expression • regulation of interleukin-1 alpha production • macromolecule biosynthetic process • regulation of gene expression • interleukin-1 alpha production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • endothelial cell migration • cell migration • cell motility • signaling • cell-cell signaling • cell communication • cellular response to stimulus • response to stimulus • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • negative regulation of cellular process • regulation of immune system process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • negative regulation of tissue remodeling • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • protein phosphorylation • phosphorylation • primary metabolic process • macromolecule modification • phosphate-containing compound metabolic process • protein metabolic process • protein modification process • phosphorus metabolic process • calcitonin gene-related peptide receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • cell adhesion • cell-cell adhesion • leukocyte cell-cell adhesion • mononuclear cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • positive regulation of hemopoiesis • regulation of macrophage differentiation • positive regulation of immune system process • positive regulation of cell development • macrophage differentiation • positive regulation of myeloid leukocyte differentiation • positive regulation of macrophage differentiation • positive regulation of myeloid cell differentiation • positive regulation of leukocyte differentiation • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • regulation of systemic arterial blood pressure • nervous system process • nervous system process involved in regulation of systemic arterial blood pressure • vasculature development • system development • circulatory system development • regulation of localization • regulation of calcium ion transport • cellular localization • regulation of calcium ion transport into cytosol • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • negative regulation of transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • negative regulation of transmembrane transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • monoatomic ion transport • negative regulation of cation transmembrane transport • negative regulation of calcium ion transport into cytosol • monoatomic cation transport • regulation of metal ion transport • calcium ion transmembrane import into cytosol • regulation of transport • regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • negative regulation of calcium ion transport • transmembrane transport • regulation of transmembrane transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • negative regulation of cytosolic calcium ion concentration • calcium ion transmembrane transport • calcium ion transport into cytosol • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • G protein-coupled receptor internalization • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • negative regulation of blood pressure • extracellular region • extracellular space • calcitonin family binding • calcitonin gene-related peptide binding • amide binding • peptide hormone binding • hormone binding • molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin gene-related peptide receptor activity • amylin receptor activity • establishment of protein localization • nitrogen compound transport • intracellular transport • protein transport • establishment of localization in cell • macromolecule localization • intracellular protein localization • intracellular protein transport • blood vessel morphogenesis • tube development • angiogenesis • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • cell surface
SCOP2	Domain Identifier	• FnI-like domain • G protein-coupled receptor-like • RAMP1-like
SCOP2	Family Identifier	• FnI-like domain • G protein-coupled receptor-like • RAMP1-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16602
Sequence	>7KNU_Chain_R Q L G V T R N K I M T A Q Y E C Y Q K I M Q Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D N W F R H P A S N R T W T N Y T Q C N V N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F K S L S C Q R I T L H K N L F F S F V C N S V V T I I H L T A V A N N Q A L V A T N P V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V A V F A E K Q H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y N D N C W I S S D T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K N L Y M K A V R A T L I L V P L L G I E F V L I P W E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E V Q A I L R R N W N Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>7KNU_Chain_E E A N Y G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S G R A V R D P P G S I L Y P F I V V P I T V T L L V T A L V V W Q S K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	doi.org/10.1126/science.abf7258

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