Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Q45 7.422505
2R:R:Y46 10.12622
3R:R:E47 5.425426
4R:R:Y49 9.015403
5R:R:Q50 9.1625424
6R:R:W69 10.685407
7R:R:W72 8.468515
8R:R:L73 6.34575
9R:R:W75 12.1917679
10R:R:V78 4.17407
11R:R:C88 6.44419
12R:R:Y91 8.41833615
13R:R:F92 9.05516
14R:R:D94 7.54615
15R:R:F95 8.28667615
16R:R:W111 10.53509
17R:R:H114 9.218594
18R:R:Y124 9.255404
19R:R:L141 10.60254116
20R:R:F142 4.52406
21R:R:F163 6.0425407
22R:R:Q172 6.032547
23R:R:P209 3.248535
24R:R:C212 4.435439
25R:R:Y221 6.022558
26R:R:L222 3.8925455
27R:R:F228 6.105455
28R:R:W229 8.02509
29R:R:L231 5.29408
30R:R:I235 5.2325406
31R:R:Y236 8.594548
32R:R:H238 6.8275408
33R:R:Q250 6.996546
34R:R:Y255 5.41143748
35R:R:F262 7.828554
36R:R:P263 4.85559
37R:R:H270 8.3054158
38R:R:Y277 4.99403
39R:R:Y278 10.648566
40R:R:C282 4.7625439
41R:R:W283 9.954538
42R:R:T288 7.1825465
43R:R:V315 1.55408
44R:R:L341 5.14754139
45R:R:E348 6.745408
46R:R:F349 7.31754168
47R:R:H374 10.925409
48R:R:F375 5.7785127
49R:R:L378 4.925406
50R:R:V380 4.615409
51R:R:F384 7.5445138
52R:R:R396 2.00254205
53L:L:F11 4.2625410
54E:E:Y32 4.12716
55E:E:L36 4.28415
56E:E:W56 7.43405
57E:E:W59 8.365627
58E:E:Y66 7.245429
59E:E:M76 4.445414
60E:E:W84 7.665617
61E:E:E88 6.525414
62E:E:V89 4.282518
63E:E:F92 6.23405
64E:E:H97 9.4425429
65E:E:R109 10.0425425
66E:E:D113 6.4075469
67E:E:P114 5.8325409
68E:E:T130 2.5225409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F11 R:R:W72 64.38268.02YesYes105
2L:L:F11 R:R:G71 53.24713.01YesNo004
3R:R:G71 R:R:W69 53.18449.85NoYes047
4R:R:Q45 R:R:W69 35.800913.14YesYes057
5E:E:Y66 R:R:Q45 30.14816.76YesYes095
6E:E:W59 E:E:Y66 22.70966.75YesYes279
7E:E:F93 R:R:Q45 12.425.86NoYes095
8R:R:C48 R:R:W69 11.36379.14NoYes097
9E:E:H97 R:R:Y49 13.65986.53YesYes093
10E:E:D90 R:R:Y49 10.14193.45NoYes083
11E:E:G108 R:R:E47 13.6241.64NoYes056
12E:E:G108 E:E:S107 11.70391.86NoNo055
13R:R:W72 R:R:Y124 13.100314.47YesYes054
14R:R:F95 R:R:W72 45.59376.01YesYes155
15R:R:F112 R:R:H114 10.36126.79NoYes054
16R:R:H114 R:R:W121 22.047214.81YesNo048
17R:R:N123 R:R:W121 23.68089.04NoNo088
18R:R:N123 R:R:Q126 25.23836.6NoNo1085
19R:R:Q126 R:R:V129 28.5281.43NoNo052
20R:R:N130 R:R:V129 30.12588.87NoNo022
21R:R:E133 R:R:N130 31.714611.83NoNo012
22R:R:E133 R:R:K134 33.29452.7NoNo013
23R:R:D96 R:R:K134 34.86552.77NoNo053
24R:R:D96 R:R:E99 39.52476.5NoNo055
25R:R:C88 R:R:E99 22.15019.12YesNo195
26R:R:C88 R:R:F95 20.08685.59YesYes195
27R:R:C127 R:R:E99 18.90523.04NoNo195
28R:R:C127 R:R:F95 19.630313.97NoYes195
29R:R:D94 R:R:F95 10.10617.17YesYes155
30E:E:W84 L:L:F11 34.19863.01YesYes170
31E:E:T73 E:E:W84 10.007612.13NoYes187
32E:E:A77 E:E:W84 10.01213.89NoYes087
33E:E:V89 E:E:W84 13.34654.9YesYes187
34E:E:F92 E:E:F93 23.05427.5YesNo059
35E:E:M76 E:E:Y32 17.45073.59YesYes146
36E:E:F44 E:E:L69 11.1319.74NoNo098
37E:E:F44 E:E:Y100 13.825413.41NoNo097
38E:E:T62 E:E:W59 13.07343.64NoYes087
39E:E:F92 E:E:V96 17.13295.24YesNo057
40E:E:R99 E:E:Y100 13.941719.55NoNo027
41E:E:F93 R:R:Y49 12.151515.47NoYes093
42R:R:W69 R:R:Y49 17.20910.61YesYes073
43E:E:Y66 R:R:Y46 10.20458.94YesYes292
44E:E:R99 E:E:V96 15.927.85NoNo027
45R:R:H374 R:R:T145 14.138720.54YesNo097
46R:R:L195 R:R:T145 12.76464.42NoNo077
47R:R:F142 R:R:L195 11.38162.44YesNo067
48R:R:L378 R:R:S152 20.18987.51YesNo069
49R:R:G377 R:R:S152 21.81443.71NoNo099
50R:R:G377 R:R:V380 23.43021.84NoYes099
51R:R:F184 R:R:V380 71.34676.55NoYes089
52R:R:F184 R:R:N226 71.839112.08NoNo1488
53R:R:N187 R:R:N226 74.242513.62NoNo088
54R:R:L222 R:R:N187 75.50914.12YesNo058
55R:R:L222 R:R:Y221 39.74853.52YesYes558
56R:R:P263 R:R:Y221 42.34448.34YesYes598
57R:R:F228 R:R:P263 61.75985.78YesYes559
58R:R:F228 R:R:G224 1003.01YesNo055
59R:R:G224 R:R:I298 99.41373.53NoNo057
60R:R:F349 R:R:I298 95.73023.77YesNo1687
61R:R:E348 R:R:F349 50.09189.33YesYes088
62R:R:E348 R:R:M373 37.34069.47YesNo087
63R:R:H374 R:R:M373 36.12765.25YesNo097
64R:R:C225 R:R:L222 38.47743.17NoYes585
65R:R:C225 R:R:P263 38.99663.77NoYes589
66R:R:H149 R:R:H374 12.76468.36NoYes079
67R:R:F181 R:R:V380 45.08792.62NoYes089
68R:R:F163 R:R:F181 35.57715.36YesNo078
69R:R:F163 R:R:I162 18.50696.28YesNo078
70R:R:I162 R:R:V391 16.91363.07NoNo089
71R:R:F163 R:R:I174 11.932110.05YesNo079
72R:R:F228 R:R:F262 39.381512.86YesYes554
73R:R:F262 R:R:L258 44.05853.65YesNo046
74R:R:L231 R:R:L258 42.69795.54YesNo086
75R:R:I235 R:R:L231 40.76444.28YesYes068
76R:R:I235 R:R:Y255 36.03816.04YesYes068
77R:R:Y236 R:R:Y255 17.7464.96YesYes488
78R:R:L252 R:R:Y255 10.18665.86NoYes068
79R:R:E233 R:R:H177 18.76657.39NoNo099
80R:R:E233 R:R:L176 20.25697.95NoNo099
81R:R:L176 R:R:Y236 16.565.86NoYes098
82R:R:F384 R:R:L341 23.93146.09YesYes1389
83R:R:L341 R:R:V380 33.83617.45YesYes099
84R:R:H270 R:R:R274 15.051713.54YesNo087
85R:R:L290 R:R:R274 37.34063.64NoNo037
86R:R:L290 R:R:T288 38.54452.95NoYes035
87R:R:L291 R:R:T288 62.76694.42NoYes055
88R:R:H295 R:R:L291 63.76493.86NoNo065
89R:R:F349 R:R:H295 64.75417.92YesNo086
90R:R:R274 R:R:W283 21.742816.99NoYes078
91R:R:K213 R:R:W283 16.497318.57NoYes388
92R:R:C282 R:R:K213 11.01914.85YesNo398
93R:R:F308 R:R:I235 22.19497.54NoYes086
94R:R:F308 R:R:H238 20.136113.58NoYes088
95R:R:H238 R:R:I312 10.42832.65YesNo089
96E:E:T130 R:R:F262 21.18785.19YesYes094
97E:E:D113 R:R:T288 21.836810.12YesYes695
98E:E:D113 E:E:P114 16.85994.83YesYes099
99R:R:G296 R:R:P297 11.66814.06NoNo048
100E:E:T130 R:R:P297 15.70961.75YesNo098
101R:R:C299 R:R:G296 10.24031.96NoNo044
102R:R:F384 R:R:T338 10.54926.49YesNo089
103R:R:E348 R:R:M369 11.38162.71YesNo088
104R:R:N388 R:R:V391 15.26218.87NoNo099
105R:R:G389 R:R:N388 11.93211.7NoNo069
106R:R:G389 R:R:Q392 10.25381.64NoNo067
107R:R:F384 R:R:H177 17.338813.58YesNo089
108R:R:F262 R:R:P263 19.99284.33YesYes549
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:G71 R:R:W69 9.85 0 No Yes 4 7 1 2
L:L:F11 R:R:G71 3.01 1 Yes No 0 4 0 1
R:R:W72 R:R:Y91 4.82 1 Yes Yes 5 5 1 2
R:R:F92 R:R:W72 9.02 1 Yes Yes 6 5 1 1
R:R:F95 R:R:W72 6.01 1 Yes Yes 5 5 1 1
R:R:W72 R:R:Y124 14.47 1 Yes Yes 5 4 1 2
L:L:F11 R:R:W72 8.02 1 Yes Yes 0 5 0 1
R:R:C88 R:R:F95 5.59 1 Yes Yes 9 5 2 1
R:R:C127 R:R:C88 7.28 1 No Yes 9 9 2 2
R:R:F92 R:R:Y91 9.28 1 Yes Yes 6 5 1 2
R:R:D94 R:R:F92 4.78 1 Yes Yes 5 6 1 1
R:R:F92 R:R:F95 11.79 1 Yes Yes 6 5 1 1
L:L:T4 R:R:F92 10.38 1 No Yes 0 6 0 1
L:L:F1 R:R:Q93 10.54 0 No No 0 4 0 1
R:R:D94 R:R:F95 7.17 1 Yes Yes 5 5 1 1
R:R:D94 R:R:N128 8.08 1 Yes No 5 3 1 1
L:L:F1 R:R:D94 10.75 0 No Yes 0 5 0 1
L:L:T4 R:R:D94 13.01 1 No Yes 0 5 0 1
R:R:C127 R:R:F95 13.97 1 No Yes 9 5 2 1
L:L:T4 R:R:F95 5.19 1 No Yes 0 5 0 1
R:R:F112 R:R:H114 6.79 0 No Yes 5 4 2 1
R:R:H114 R:R:P115 9.15 9 Yes No 4 3 1 2
R:R:H114 R:R:S117 6.97 9 Yes No 4 4 1 1
R:R:H114 R:R:W121 14.81 9 Yes No 4 8 1 2
L:L:S8 R:R:H114 8.37 9 No Yes 0 4 0 1
R:R:R119 R:R:S117 5.27 0 No No 4 4 1 1
L:L:S8 R:R:S117 6.52 9 No No 0 4 0 1
E:E:F83 R:R:R119 19.24 0 No No 5 4 2 1
L:L:V6 R:R:N128 11.82 0 No No 0 3 0 1
E:E:W74 L:L:F11 3.01 1 No Yes 7 0 1 0
E:E:W84 L:L:F11 3.01 1 Yes Yes 7 0 1 0
E:E:T73 E:E:W84 12.13 1 No Yes 8 7 2 1
E:E:T73 E:E:V89 4.76 1 No Yes 8 8 2 2
E:E:E78 E:E:W74 18.54 0 No No 3 7 2 1
E:E:W74 E:E:W84 11.25 1 No Yes 7 7 1 1
E:E:A77 E:E:W84 3.89 0 No Yes 8 7 2 1
E:E:P85 E:E:W84 10.81 1 No Yes 9 7 2 1
E:E:V89 E:E:W84 4.9 1 Yes Yes 8 7 2 1
E:E:P85 E:E:V89 3.53 1 No Yes 9 8 2 2
L:L:P3 R:R:N128 1.63 0 No No 0 3 0 1
R:R:D94 R:R:T131 1.45 1 Yes No 5 1 1 2
L:L:K9 R:R:R119 1.24 0 No No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
33.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
33.33Single6D35Cholesterol6D35-SMO-Cholesterol
33.33Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
33.33Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
33.33Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
33.33Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
33.33Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
33.33Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
33.33Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
33.33Single7DTTCa7DTT-CaS-Ca-Ca
33.33Single7DTTCa7DTT-CaS-Ca-Ca
33.33Single7DTUTryptophan7DTU-CaS-Tryptophan
33.33Single7DTUTryptophan7DTU-CaS-Tryptophan
33.33Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
33.33Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
33.33Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
33.33Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
33.33Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
33.33Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
33.33Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
33.33Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
33.33Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
33.33Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
33.33Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
33.33Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
33.33Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
33.33Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
33.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
33.33Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
33.33Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
33.33Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
33.33Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
33.33Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
33.33Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
33.33Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
33.33Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
33.33Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
33.33Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
33.33Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
33.33Single7XW7K1-707XW7-TSH-K1-70
33.33Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
33.33Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
33.33Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
33.33Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
33.33Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
33.33Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
33.33Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
33.33Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
33.33Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
33.33Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
33.33Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
33.33Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
33.33Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
33.33Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
33.33Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
33.33Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
33.33Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
33.33Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
33.33Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
33.33Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
33.33Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
33.33Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
33.33Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
33.33Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
33.33Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
33.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
33.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
33.33Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
33.33Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
33.33Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
33.33Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
33.33Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
33.33Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
33.33Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
33.33Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
33.33Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
33.33Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
33.33Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
33.33Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
33.33Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
33.33Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
33.33Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
33.33Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
33.33Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
33.33Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
33.33Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
33.33Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8WVXNorrin8WVX-LGR4-Norrin
33.33Single8WVYNorrin8WVY-LGR4-Norrin
33.33Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
33.33Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
33.33Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
33.33Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
33.33Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
33.33Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
33.33Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
33.33Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
33.33Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
33.33Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
33.33Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
33.33Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
25.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
25.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
16.67Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.67Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
16.67Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
16.67Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
14.29Single5L7DCholesterol5L7D-SMO-Cholesterol
14.29Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
14.29Single8HS2Fab0468HS2-GPR20-Fab046
14.29Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
14.29Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
12.50Consensusp2y_offOrthosteric Ligandp2y1_off
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.11Single8JPSCCL78JPS-ACKR1-CCL7
11.11Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single6LI0C176LI0-GPR52-C17
10.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Single9B9Y7DY9B9Y-CB1-7DY
9.09Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
9.09Single4BWBNeurotensin4BWB-NTS1-Neurotensin
9.09Single4QINSAG1.54QIN-SMO-SAG1.5
9.09Single5U09Taranabant5U09-CB1-Taranabant
9.09Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.09Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.09Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.09Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
9.09Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.09Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
9.09Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.09Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.09Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.09Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
9.09Single9BA0A1AKN9BA0-CB1-A1AKN
9.09Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.09Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
8.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
8.33Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.33Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
8.33Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
8.33Single7VV6C48/807VV6-MRGPRX2-C48/80
8.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
8.33Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
8.33Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensusgrh_offOrthosteric Ligandgnrh1_off
8.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
8.33Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.69Single4QIMANTA XV4QIM-SMO-ANTA XV
7.69Single5T04Neurotensin5T04-NTS1-Neurotensin
7.69Single5TGZAM65385TGZ-CB1-AM6538
7.69Single6D27CAY104716D27-DP2-CAY10471
7.69Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
7.69Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.69Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
7.69Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.69Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
7.69Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
7.69Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
7.69Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
7.69Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
7.69Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
7.69Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
7.69Single7YXAONO-54306087YXA-S1P5-ONO-5430608
7.69Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69Single9B9ZA1AKO9B9Z-CB1-A1AKO
7.69Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
7.69Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
7.69Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
7.69Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
7.41Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.14Single4JKVTaladegib4JKV-SMO-Taladegib
7.14Single5C1MBU725C1M-μ-BU72
7.14Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
7.14Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
7.14Single7C4SS1P7C4S-S1P3-S1P
7.14Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
7.14Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
7.14Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
7.14Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
7.14Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
6.67Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
6.67Single4BV0Neurotensin4BV0-NTS1-Neurotensin
6.67Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
6.67Single5V56TC1145V56-SMO-TC114
6.67Single5V57TC1145V57-SMO-TC114
6.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.67Single6OS1TRV0266OS1-AT1-TRV026
6.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
6.67Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
6.67Single7F1TMIP-1a7F1T-CCR5-MIP-1a
6.67Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
6.67Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
6.67Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
6.67Single7R0CAVP7R0C-V2-AVP-Arrestin2
6.67Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
6.67Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
6.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
6.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8E0GBU728E0G-μ-BU72
6.67Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
6.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
6.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
6.67Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
6.67Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
6.67Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
6.67Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
6.67Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
6.67Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
6.67Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
6.67Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Consensuslpa_onOrthosteric Ligandlpa1_on
6.67Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
6.67Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusneurotensin_onOrthosteric Ligandnts1_on
6.67Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.67Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
6.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
6.67Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
6.25Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
6.25Single4XEENeurotensin4XEE-NTS1-Neurotensin
6.25Single4XESNeurotensin4XES-NTS1-Neurotensin
6.25Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
6.25Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
6.25Single6OS2TRV0266OS2-AT1-TRV026
6.25Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
6.25Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
6.25Single6YVRNTS8-136YVR-NTS1-NTS8-13
6.25Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
6.25Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.25Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.25Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
6.25Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
6.25Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
6.25Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
6.25Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XWACXCL18XWA-CXCR2-CXCL1
6.25Single8XWMCXCL68XWM-CXCR2-CXCL6
6.25Single8XWSCXCL58XWS-CXCR2-CXCL5
6.25Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
6.25Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
6.25Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
6.25Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
6.25Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
6.25Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
6.25Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.25Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
6.25Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
6.25Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
6.25Consensuslpa_offOrthosteric Ligandlpa1_off
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
6.25Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
6.25Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
6.25Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.25Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.25Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.25Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.88Single4BUONeurotensin4BUO-NTS1-Neurotensin
5.88Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
5.88Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
5.88Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.88Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
5.88Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
5.88Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
5.88Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
5.88Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
5.88Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
5.88Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
5.88Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
5.88Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
5.88Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
5.88Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
5.88Single8XVUCXCL28XVU-CXCR2-CXCL2
5.88Single8XWFCXCL38XWF-CXCR2-CXCL3
5.88Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
5.88Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
5.88Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.88Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
5.88Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
5.88Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
5.88Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.88Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
5.56Single6KNMJN241-96KNM-Apelin-JN241-9
5.56Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
5.56Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
5.56Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
5.56Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
5.56Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
5.56Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
5.56Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
5.56Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8QJ2pN1628QJ2-MC4-pN162-Gs
5.56Single8XQJJN2418XQJ-Apelin-JN241
5.56Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
5.56Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
5.56Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.56Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
5.56Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
5.56Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
5.56Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.26Single4XT1Fractalkine4XT1-US28-Fractalkine
5.26Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.26Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.26Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.26Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.26Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.26Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.26Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.26Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.26Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.26Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.26Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.26Single8XWNCXCL88XWN-CXCR2-CXCL8
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.26Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.26Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.26Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.26Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.26Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.26Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.26Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.00Single7SK5CXCL127SK5-ACKR3-CXCL12
5.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
4.76Single3OE0CVX153OE0-CXCR4-CVX15
4.76Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
4.76Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
4.76Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.76Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
4.76Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
4.76Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
4.76Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
4.76Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
4.76Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
4.76Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
4.76Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.76Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
4.76Consensusangiotensin_onOrthosteric Ligandat1_on
4.76Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.76Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
4.76Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
4.76Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.76Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
4.55Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
4.55Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.55Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
4.55Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.55Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.55Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
4.55Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
4.55Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
4.55Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
4.55Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.55Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
4.55Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
4.55Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
4.55Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
4.55Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
4.55Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
4.55Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.55Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
4.55Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
4.55Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
4.55Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.55Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
4.55Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
4.55Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
4.55Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
4.55Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
4.55Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.55Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.55Consensusvasop-oxy_onOrthosteric Ligandv2_on
4.55Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.35Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.35Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.35Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.35Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.35Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.35Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.35Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.35Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.35Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.35Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.35Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.35Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.35Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.35Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.35Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.35Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.35Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.35Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.35Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.35Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.35Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.35Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.35Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.35Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.35Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.35Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.17Single4XT3Fractalkine4XT3-US28-Fractalkine
4.17Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.17Single6FJ3PTH6FJ3-PTH1-PTH
4.17Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.17Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.17Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.17Single7SK3CXCL127SK3-ACKR3-CXCL12
4.17Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.17Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.17Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.17Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.17Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.17Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.17Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.17Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.17Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.17Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.17Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.17Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.17Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.17Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.00Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
3.85Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
3.85Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.85Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.85Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.85Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.85Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
3.85Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
3.85Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.85Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.85Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
3.85Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.85Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
3.85Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.85Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
3.85Single8IY6Endothelin-18IY6-ETB-Endothelin-1
3.85Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.85Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.85Consensusbradykinin_onOrthosteric Ligandbk2_on
3.85Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
3.85Consensusendothelin_onOrthosteric Ligandetb_on eta_on
3.85Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.85Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
3.70Single5GLHEndothelin-15GLH-ETB-Endothelin-1
3.70Single6IGKEndothelin-36IGK-ETB-Endothelin-3
3.70Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
3.70Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
3.70Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
3.70Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.70Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.70Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
3.70Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.57Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.57Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.57Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.57Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.57Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.57Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.57Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.57Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.57Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.45Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.45Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.45Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.45Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.45Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.45Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.45Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.33Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.33Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.33Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.33Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.33Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.33Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.33Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.12Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.03Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.94Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.86Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.63Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB 7KNU
Class B1
SubFamily Peptide
Type Calcitonin
SubType CT Like
Species Homo Sapiens
Ligand Calcitonin gene-related peptide-1
Other Ligand(s) -
Protein Partners RAMP1
PDB Resolution 3.49
Date 2021-02-24
D.O.I. 10.1126/science.abf7258
Net Summary
Imin 2.95
Number of Linked Nodes 432
Number of Links 496
Number of Hubs 68
Number of Links mediated by Hubs 252
Number of Communities 20
Number of Nodes involved in Communities 107
Number of Links involved in Communities 139
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 70376
Length Of Smallest Path 3
Average Path Length 14.5258
Length of Longest Path 33
Minimum Path Strength 1.19
Average Path Strength 6.50639
Maximum Path Strength 24.23
Minimum Path Correlation 0.7
Average Path Correlation 0.964032
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 5.88235
Average % Of Corr. Nodes 65.8248
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.983
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• calcitonin family binding   • calcitonin gene-related peptide binding   • amide binding   • binding   • peptide hormone binding   • hormone binding   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • calcitonin family receptor activity   • peptide receptor activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • transmembrane signaling receptor activity   • calcitonin gene-related peptide receptor activity   • amylin receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • protein localization   • cellular localization
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • protein localization   • cellular localization   • establishment of protein localization   • nitrogen compound transport   • transport   • intracellular transport   • establishment of localization   • localization   • protein transport   • establishment of localization in cell   • cellular macromolecule localization   • macromolecule localization   • intracellular protein transport   • regulation of signaling   • regulation of signal transduction   • regulation of response to stimulus   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • import into cell   • receptor internalization   • receptor-mediated endocytosis   • endocytosis   • vesicle-mediated transport   • developmental process   • multicellular organismal process   • blood vessel morphogenesis   • tube development   • angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • anatomical structure formation involved in morphogenesis   • anatomical structure development   • blood vessel development   • system development   • calcitonin family receptor signaling pathway   • calcitonin gene-related peptide receptor signaling pathway   • regulation of protein modification process   • positive regulation of glycoprotein metabolic process   • positive regulation of protein metabolic process   • positive regulation of biological process   • carbohydrate derivative metabolic process   • positive regulation of macromolecule biosynthetic process   • positive regulation of protein glycosylation   • regulation of primary metabolic process   • positive regulation of metabolic process   • positive regulation of protein modification process   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • protein metabolic process   • protein modification process   • positive regulation of cellular process   • regulation of glycoprotein biosynthetic process   • positive regulation of glycoprotein biosynthetic process   • carbohydrate derivative biosynthetic process   • regulation of biosynthetic process   • regulation of protein metabolic process   • glycoprotein biosynthetic process   • primary metabolic process   • regulation of macromolecule metabolic process   • glycoprotein metabolic process   • macromolecule biosynthetic process   • protein glycosylation   • regulation of glycoprotein metabolic process   • biosynthetic process   • glycosylation   • macromolecule modification   • macromolecule glycosylation   • regulation of protein glycosylation   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of metabolic process   • amylin receptor signaling pathway   • monoatomic ion transport   • monoatomic cation transport   • calcium ion transport   • metal ion transport   • protein localization to cell periphery   • protein localization to plasma membrane   • localization within membrane   • protein localization to membrane   • amylin receptor 1 signaling pathway   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to endogenous stimulus   • response to chemical   • cellular response to hormone stimulus   • protein-containing complex   • receptor complex   • cell surface   • cellular anatomical structure   • cell periphery   • plasma membrane   • membrane   • plasma membrane protein complex   • membrane protein complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • CGRP receptor complex   • calcitonin family receptor complex   • protein binding   • binding   • signaling receptor binding   • molecular transducer activity   • molecular function activator activity   • signaling receptor activity   • signaling receptor activator activity   • hormone activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • protein-containing complex binding   • cell population proliferation   • endothelial cell proliferation   • epithelial cell proliferation   • system process   • circulatory system process   • regulation of blood pressure   • regulation of biological quality   • blood circulation   • interleukin-1 production   • positive regulation of interleukin-1 alpha production   • regulation of cytokine production   • cytokine production   • regulation of multicellular organismal process   • positive regulation of interleukin-1 production   • regulation of interleukin-1 production   • gene expression   • regulation of interleukin-1 alpha production   • regulation of gene expression   • interleukin-1 alpha production   • positive regulation of gene expression   • positive regulation of multicellular organismal process   • positive regulation of cytokine production   • endothelial cell migration   • cell migration   • cell motility   • cell-cell signaling   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • cellular developmental process   • regulation of developmental process   • negative regulation of biological process   • cell development   • regulation of cell differentiation   • regulation of cell development   • regulation of osteoclast differentiation   • cell differentiation   • osteoclast differentiation   • negative regulation of cellular process   • regulation of immune system process   • negative regulation of cell differentiation   • negative regulation of hemopoiesis   • regulation of multicellular organismal development   • negative regulation of leukocyte differentiation   • hemopoiesis   • regulation of myeloid cell differentiation   • negative regulation of developmental process   • regulation of myeloid leukocyte differentiation   • negative regulation of myeloid cell differentiation   • negative regulation of osteoclast differentiation   • negative regulation of myeloid leukocyte differentiation   • negative regulation of cell development   • myeloid cell differentiation   • negative regulation of immune system process   • immune system process   • regulation of hemopoiesis   • negative regulation of multicellular organismal process   • leukocyte differentiation   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • regulation of cytosolic calcium ion concentration   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • positive regulation of interleukin-8 production   • interleukin-8 production   • regulation of interleukin-8 production   • regulation of tube diameter   • regulation of tube size   • vascular process in circulatory system   • blood vessel diameter maintenance   • vasodilation   • regulation of anatomical structure size   • negative regulation of tissue remodeling   • negative regulation of bone remodeling   • regulation of bone remodeling   • tissue homeostasis   • regulation of tissue remodeling   • regulation of bone resorption   • bone resorption   • negative regulation of bone resorption   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • protein phosphorylation   • phosphorylation   • phosphate-containing compound metabolic process   • phosphorus metabolic process   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell adhesion   • cell-cell adhesion   • leukocyte cell-cell adhesion   • mononuclear cell differentiation   • positive regulation of developmental process   • positive regulation of cell differentiation   • positive regulation of hemopoiesis   • regulation of macrophage differentiation   • positive regulation of immune system process   • positive regulation of cell development   • macrophage differentiation   • positive regulation of myeloid leukocyte differentiation   • positive regulation of macrophage differentiation   • positive regulation of myeloid cell differentiation   • positive regulation of leukocyte differentiation   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • regulation of systemic arterial blood pressure   • nervous system process   • nervous system process involved in regulation of systemic arterial blood pressure   • regulation of localization   • regulation of calcium ion transport   • regulation of calcium ion transport into cytosol   • monoatomic ion transmembrane transport   • negative regulation of monoatomic ion transport   • negative regulation of transport   • regulation of monoatomic ion transmembrane transport   • negative regulation of transmembrane transport   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • negative regulation of monoatomic ion transmembrane transport   • negative regulation of cation transmembrane transport   • negative regulation of calcium ion transport into cytosol   • regulation of metal ion transport   • calcium ion transmembrane import into cytosol   • regulation of transport   • regulation of monoatomic ion transport   • positive regulation of cytosolic calcium ion concentration   • inorganic ion transmembrane transport   • inorganic cation transmembrane transport   • negative regulation of calcium ion transport   • transmembrane transport   • regulation of transmembrane transport   • regulation of cellular localization   • regulation of monoatomic cation transmembrane transport   • negative regulation of calcium ion transmembrane transport   • negative regulation of cytosolic calcium ion concentration   • calcium ion transmembrane transport   • calcium ion transport into cytosol   • negative adaptation of signaling pathway   • negative regulation of signaling   • desensitization of G protein-coupled receptor signaling pathway   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • G protein-coupled receptor internalization   • negative regulation of response to stimulus   • negative regulation of signal transduction   • adaptation of signaling pathway   • negative regulation of blood pressure   • intracellular anatomical structure   • cytoplasm   • extracellular region   • extracellular space   • calcitonin family receptor activity   • peptide receptor activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • transmembrane signaling receptor activity   • calcitonin receptor activity   • calcitonin family binding   • amide binding   • adrenomedullin binding   • peptide hormone binding   • hormone binding   • adrenomedullin receptor activity   • calcitonin gene-related peptide receptor activity   • heart development   • animal organ development   • regulation of vascular associated smooth muscle cell proliferation   • positive regulation of vascular associated smooth muscle cell proliferation   • regulation of smooth muscle cell proliferation   • positive regulation of cell population proliferation   • smooth muscle cell proliferation   • positive regulation of smooth muscle cell proliferation   • regulation of cell population proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • cell surface receptor signaling pathway   • adrenomedullin receptor signaling pathway   • response to disaccharide   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to sucrose stimulus   • cellular response to carbohydrate stimulus   • response to carbohydrate   • response to sucrose   • cellular response to disaccharide stimulus   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • G protein-coupled receptor dimeric complex   • adrenomedullin receptor complex   • membrane-bounded organelle   • intracellular organelle   • organelle   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • lysosome   • endosome   • intracellular vesicle   • endomembrane system   • cytoplasmic vesicle   • vesicle   • endoplasmic reticulum
Gene OntologyCellular Component
SCOP2Domain Identifier• RAMP1-like   • FnI-like domain   • G protein-coupled receptor-like
SCOP2Family Identifier• RAMP1-like   • FnI-like domain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ16602
Sequence
>7KNU_Chain_R
QLGVTRNKI MTAQYECYQ KIMQYCNRT WDGWLCWND VAAGTESMQ 
LCPDYFQDF DPSEKVTKI CDNWFRHPA SNRTWTNYT QCNVNTHEK 
VKTALNLFY LTIIGHGLS IASLLISLG IFFYFKSLS CQRITLHKN 
LFFSFVCNS VVTIIHLTA VANNQALVA TNPVSCKVS QFIHLYLMG 
CNYFWMLCE GIYLHTLIV VAVFAEKQH LMWYYFLGW GFPLIPACI 
HAIARSLYY NDNCWISSD THLLYIIHG PICAALLVN LFFLLNIVR 
VLITKNLYM KAVRATLIL VPLLGIEFV LIPWEVYDY IMHILMHFQ 
GLLVSTIFC FFNGEVQAI LRRNWNQY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainE
ProteinRAMP1
UniProtO60894
Sequence
>7KNU_Chain_E
EANYGALLR ELCLTQFQV DMEAVGETL WCDWGRTIR SYRELADCT 
WHMAEKLGC FWPNAEVDR FFLAVHGRY FRSCPISGR AVRDPPGSI 
LYPFIVVPI TVTLLVTAL VVWQSKR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7KNTB1PeptideCalcitoninCT LikeHomo sapiens--RAMP13.152021-02-2410.1126/science.abf7258
6E3YB1PeptideCalcitoninCT LikeHomo sapiensCalcitonin gene-related peptide-1-Gs/β1/γ2; RAMP13.32018-09-1910.1038/s41586-018-0535-y




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