psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C2	L:L:C7	7.28	No	Yes	2	0	0
2	L:L:C2	L:L:R11	2.79	No	No	2	0	0
3	L:L:C2	R:R:Y292	4.03	No	No	0	0	6
4	L:L:D3	R:R:W354	8.93	No	No	0	0	5
5	L:L:T4	L:L:T6	4.71	No	No	0	0	0
6	L:L:A5	R:R:M369	4.83	No	No	0	0	8
7	L:L:T6	R:R:H295	6.85	No	Yes	0	0	6
8	L:L:T6	R:R:C299	3.38	No	No	0	0	4
9	L:L:C7	L:L:H10	4.42	Yes	Yes	2	0	0
10	L:L:C7	L:L:R11	2.79	Yes	No	2	0	0
11	L:L:C7	R:R:H295	7.37	Yes	Yes	2	0	6
12	L:L:R11	L:L:V8	5.23	No	Yes	0	0	0
13	L:L:V8	R:R:H370	6.92	Yes	Yes	0	0	7
14	L:L:V8	R:R:M373	4.56	Yes	Yes	0	0	7
15	L:L:H10	R:R:H219	4.78	Yes	Yes	2	0	6
16	L:L:H10	R:R:L220	2.57	Yes	Yes	2	0	7
17	L:L:H10	R:R:M223	6.57	Yes	Yes	2	0	6
18	L:L:H10	R:R:L291	2.57	Yes	No	2	0	5
19	L:L:H10	R:R:H295	7.17	Yes	Yes	2	0	6
20	L:L:L12	L:L:L16	5.54	Yes	No	2	0	0
21	L:L:L12	R:R:F142	2.44	Yes	Yes	2	0	6
22	L:L:L12	R:R:L195	4.15	Yes	No	2	0	7
23	L:L:L12	R:R:H370	5.14	Yes	Yes	2	0	7
24	L:L:G14	R:R:S286	3.71	No	No	0	0	7
25	L:L:L15	L:L:S19	3	No	No	0	0	0
26	L:L:L15	R:R:K134	2.82	No	No	0	0	3
27	L:L:L16	R:R:F142	4.87	No	Yes	2	0	6
28	L:L:S17	R:R:V205	4.85	No	No	0	0	4
29	L:L:R18	R:R:D90	7.15	No	No	0	0	3
30	L:L:R18	R:R:P97	4.32	No	No	0	0	3
31	L:L:R18	R:R:D287	2.38	No	No	0	0	3
32	L:L:S19	R:R:V135	3.23	No	Yes	0	0	1
33	L:L:G21	R:R:Q93	3.29	No	No	0	0	4
34	L:L:V23	R:R:H132	2.77	No	No	0	0	2
35	L:L:V23	R:R:V135	4.81	No	Yes	9	0	1
36	L:L:V23	R:R:L139	2.98	No	No	9	0	3
37	L:L:F27	R:R:Q93	4.68	No	No	0	0	4
38	L:L:F27	R:R:D94	8.36	No	Yes	0	0	5
39	L:L:P29	L:L:V28	3.53	No	No	0	0	0
40	L:L:T30	R:R:W72	2.43	Yes	Yes	1	0	5
41	L:L:T30	R:R:F92	14.27	Yes	Yes	1	0	6
42	L:L:T30	R:R:D94	8.67	Yes	Yes	1	0	5
43	L:L:T30	R:R:F95	7.78	Yes	Yes	1	0	5
44	L:L:A36	L:L:N31	6.25	No	No	0	0	0
45	L:L:V32	R:R:F95	2.62	Yes	Yes	0	0	5
46	L:L:V32	R:R:Y124	2.52	Yes	Yes	0	0	4
47	L:L:V32	R:R:T125	3.17	Yes	Yes	0	0	6
48	L:L:V32	R:R:N128	5.91	Yes	No	0	0	3
49	L:L:S34	R:R:H114	15.34	No	Yes	5	0	4
50	L:L:S34	R:R:A116	3.42	No	No	5	0	3
51	L:L:S34	R:R:S117	4.89	No	No	0	0	4
52	L:L:F37	R:R:G71	3.01	Yes	No	0	0	4
53	L:L:F37	R:R:W72	7.02	Yes	Yes	1	0	5
54	E:E:W84	L:L:F37	4.01	Yes	Yes	1	9	0
55	E:E:P85	L:L:F37	2.89	No	Yes	1	9	0
56	R:R:L34	R:R:R38	3.64	No	No	0	2	5
57	R:R:G35	R:R:R38	3	No	No	0	2	5
58	R:R:I41	R:R:T37	3.04	No	No	0	6	4
59	E:E:I63	R:R:N39	5.66	No	No	0	4	5
60	E:E:R67	R:R:N39	6.03	No	No	0	3	5
61	R:R:I41	R:R:M42	2.92	No	Yes	0	6	3
62	R:R:I41	R:R:Y91	4.84	No	Yes	0	6	5
63	R:R:M42	R:R:Q45	2.72	Yes	Yes	0	3	5
64	E:E:R67	R:R:M42	2.48	No	Yes	0	3	3
65	E:E:A70	R:R:M42	3.22	No	Yes	0	8	3
66	R:R:E47	R:R:T43	2.82	No	No	0	6	5
67	E:E:W59	R:R:T43	7.28	Yes	No	0	9	5
68	R:R:A44	R:R:W69	2.59	No	Yes	0	6	7
69	R:R:A44	R:R:Y91	2.67	No	Yes	0	6	5
70	R:R:Q45	R:R:Y49	9.02	Yes	Yes	1	5	3
71	R:R:Q45	R:R:W69	18.62	Yes	Yes	1	5	7
72	E:E:Y66	R:R:Q45	4.51	Yes	Yes	1	9	5
73	E:E:F93	R:R:Q45	4.68	Yes	Yes	1	9	5
74	R:R:Q50	R:R:Y46	13.53	No	Yes	1	4	2
75	E:E:W59	R:R:Y46	17.36	Yes	Yes	1	9	2
76	E:E:Y66	R:R:Y46	4.96	Yes	Yes	1	9	2
77	E:E:H97	R:R:Y46	6.53	Yes	Yes	1	9	2
78	E:E:F101	R:R:Y46	12.38	Yes	Yes	1	9	2
79	E:E:C104	R:R:Y46	2.69	Yes	Yes	1	9	2
80	E:E:R109	R:R:Y46	17.49	Yes	Yes	1	9	2
81	E:E:R109	R:R:E47	3.49	Yes	No	0	9	6
82	E:E:A110	R:R:E47	4.53	No	No	0	6	6
83	R:R:C48	R:R:I52	3.27	No	Yes	1	9	5
84	R:R:C48	R:R:W69	7.84	No	Yes	1	9	7
85	R:R:C48	R:R:C74	7.28	No	No	1	9	9
86	R:R:I52	R:R:Y49	2.42	Yes	Yes	1	5	3
87	R:R:W69	R:R:Y49	6.75	Yes	Yes	1	7	3
88	E:E:D90	R:R:Y49	5.75	No	Yes	0	9	3
89	E:E:F93	R:R:Y49	10.32	Yes	Yes	1	9	3
90	E:E:H97	R:R:Y49	8.71	Yes	Yes	1	9	3
91	R:R:M53	R:R:Q50	4.08	Yes	No	1	2	4
92	E:E:H97	R:R:Q50	6.18	Yes	No	1	9	4
93	R:R:K51	R:R:N76	8.39	No	No	0	3	6
94	R:R:I52	R:R:R67	8.77	Yes	No	0	5	4
95	R:R:C74	R:R:I52	3.27	No	Yes	1	9	5
96	R:R:M53	R:R:Q54	5.44	Yes	No	0	2	2
97	E:E:L94	R:R:M53	2.83	No	Yes	0	5	2
98	E:E:H97	R:R:M53	2.63	Yes	Yes	1	9	2
99	E:E:I106	R:R:Q54	6.86	No	No	0	4	2
100	R:R:N66	R:R:Y64	4.65	No	No	10	5	3
101	R:R:D77	R:R:Y64	8.05	No	No	10	4	3
102	R:R:C105	R:R:C65	7.28	No	No	1	9	9
103	R:R:C65	R:R:W111	15.67	No	Yes	1	9	9
104	R:R:D77	R:R:N66	2.69	No	No	10	4	5
105	R:R:D77	R:R:R67	19.06	No	No	0	4	4
106	R:R:T68	R:R:W111	3.64	No	Yes	0	5	9
107	E:E:D90	R:R:T68	5.78	No	No	0	9	5
108	R:R:G71	R:R:W69	7.04	No	Yes	0	4	7
109	R:R:C74	R:R:W69	2.61	No	Yes	1	9	7
110	R:R:D70	R:R:L73	2.71	Yes	Yes	1	9	5
111	R:R:D70	R:R:W75	11.17	Yes	Yes	1	9	9
112	R:R:D70	R:R:T122	8.67	Yes	Yes	1	9	7
113	R:R:D70	R:R:Y124	8.05	Yes	Yes	1	9	4
114	R:R:W72	R:R:Y91	4.82	Yes	Yes	1	5	5
115	R:R:F92	R:R:W72	7.02	Yes	Yes	1	6	5
116	R:R:F95	R:R:W72	6.01	Yes	Yes	1	5	5
117	R:R:W72	R:R:Y124	23.15	Yes	Yes	1	5	4
118	R:R:L73	R:R:W75	3.42	Yes	Yes	1	5	9
119	R:R:L73	R:R:Q86	14.64	Yes	No	1	5	5
120	R:R:L73	R:R:P89	9.85	Yes	No	0	5	8
121	R:R:L73	R:R:V101	4.47	Yes	No	1	5	7
122	R:R:L73	R:R:Y124	7.03	Yes	Yes	1	5	4
123	R:R:S84	R:R:W75	2.47	No	Yes	0	7	9
124	R:R:Q86	R:R:W75	9.86	No	Yes	1	5	9
125	R:R:K103	R:R:W75	9.28	No	Yes	1	8	9
126	R:R:T122	R:R:W75	4.85	Yes	Yes	1	7	9
127	R:R:T82	R:R:V78	4.76	No	No	0	5	7
128	R:R:S84	R:R:V78	4.85	No	No	0	7	7
129	R:R:V78	R:R:W111	2.45	No	Yes	0	7	9
130	R:R:E83	R:R:T102	9.88	No	No	0	3	5
131	R:R:E83	R:R:I104	9.56	No	No	0	3	4
132	R:R:K100	R:R:M85	10.08	No	No	0	3	4
133	R:R:C88	R:R:E99	3.04	No	Yes	0	9	5
134	R:R:C88	R:R:V101	3.42	No	No	0	9	7
135	R:R:C127	R:R:C88	7.28	No	No	0	9	9
136	R:R:P89	R:R:Y91	15.3	No	Yes	0	8	5
137	R:R:F92	R:R:Y91	3.09	Yes	Yes	1	6	5
138	R:R:D94	R:R:F92	2.39	Yes	Yes	1	5	6
139	R:R:F92	R:R:F95	8.57	Yes	Yes	1	6	5
140	R:R:D94	R:R:F95	4.78	Yes	Yes	1	5	5
141	R:R:D94	R:R:N128	5.39	Yes	No	0	5	3
142	R:R:C127	R:R:F95	4.19	No	Yes	0	9	5
143	R:R:D96	R:R:P97	6.44	Yes	No	0	5	3
144	R:R:D96	R:R:S98	5.89	Yes	No	0	5	3
145	R:R:D96	R:R:E99	3.9	Yes	Yes	0	5	5
146	R:R:D96	R:R:K134	12.44	Yes	No	0	5	3
147	R:R:E99	R:R:Q126	5.1	Yes	No	0	5	5
148	R:R:E99	R:R:N130	9.2	Yes	No	0	5	2
149	R:R:V101	R:R:Y124	11.36	No	Yes	1	7	4
150	R:R:N123	R:R:T102	4.39	No	No	0	8	5
151	R:R:K103	R:R:W111	19.73	No	Yes	1	8	9
152	R:R:K103	R:R:T122	16.52	No	Yes	1	8	7
153	R:R:F112	R:R:I104	3.77	No	No	0	5	4
154	R:R:C105	R:R:W111	5.22	No	Yes	1	9	9
155	R:R:D106	R:R:N110	6.73	No	No	0	5	5
156	R:R:F112	R:R:P115	2.89	No	No	0	5	3
157	R:R:N118	R:R:R113	6.03	No	No	0	6	1
158	R:R:R113	R:R:T120	7.76	No	No	11	1	5
159	E:E:F83	R:R:R113	5.34	No	No	11	5	1
160	R:R:H114	R:R:P115	9.15	Yes	No	0	4	3
161	R:R:A116	R:R:H114	2.93	No	Yes	5	3	4
162	R:R:H114	R:R:W121	15.87	Yes	No	5	4	8
163	R:R:R119	R:R:S117	5.27	No	No	0	4	4
164	E:E:F83	R:R:R119	9.62	No	No	0	5	4
165	E:E:F83	R:R:T120	3.89	No	No	11	5	5
166	R:R:N123	R:R:W121	13.56	No	No	5	8	8
167	R:R:T125	R:R:W121	2.43	Yes	No	5	6	8
168	R:R:T122	R:R:Y124	11.24	Yes	Yes	1	7	4
169	R:R:N123	R:R:T125	10.24	No	Yes	5	8	6
170	R:R:C127	R:R:Y124	2.69	No	Yes	0	9	4
171	R:R:Q126	R:R:T125	2.83	No	Yes	0	5	6
172	R:R:E133	R:R:N130	5.26	No	No	0	1	2
173	R:R:E133	R:R:K134	2.7	No	No	0	1	3
174	R:R:L139	R:R:V135	2.98	No	Yes	9	3	1
175	R:R:L141	R:R:T137	2.95	Yes	No	2	6	4
176	R:R:T137	R:R:Y367	2.5	No	No	2	4	6
177	R:R:L141	R:R:L144	2.77	Yes	No	2	6	6
178	R:R:D366	R:R:L141	4.07	No	Yes	2	6	6
179	R:R:L141	R:R:Y367	5.86	Yes	No	2	6	6
180	R:R:H370	R:R:L141	18	Yes	Yes	2	7	6
181	R:R:F142	R:R:I146	7.54	Yes	Yes	2	6	6
182	R:R:F142	R:R:L195	4.87	Yes	No	2	6	7
183	R:R:F142	R:R:T196	5.19	Yes	No	2	6	3
184	R:R:H370	R:R:L144	2.57	Yes	No	2	7	6
185	R:R:H370	R:R:T145	2.74	Yes	No	2	7	7
186	R:R:H374	R:R:T145	17.8	Yes	No	2	9	7
187	R:R:I146	R:R:I192	2.94	Yes	No	0	6	6
188	R:R:I146	R:R:T196	3.04	Yes	No	2	6	3
189	R:R:F375	R:R:I147	2.51	No	No	0	7	5
190	R:R:F375	R:R:G148	9.03	No	No	0	7	9
191	R:R:H149	R:R:S188	11.16	No	No	0	7	8
192	R:R:H149	R:R:I192	2.65	No	No	0	7	6
193	R:R:H149	R:R:H374	10.75	No	Yes	0	7	9
194	R:R:L156	R:R:S152	3	Yes	No	0	9	9
195	R:R:G377	R:R:S152	3.71	No	No	0	9	9
196	R:R:I153	R:R:S188	6.19	No	No	0	6	8
197	R:R:L378	R:R:S155	3	No	No	0	6	6
198	R:R:S155	R:R:S381	6.52	No	Yes	6	6	8
199	R:R:F386	R:R:S155	2.64	Yes	No	6	8	6
200	R:R:F181	R:R:L156	7.31	Yes	Yes	0	8	9
201	R:R:F184	R:R:L156	2.44	Yes	Yes	0	8	9
202	R:R:L156	R:R:S381	4.5	Yes	Yes	0	9	8
203	R:R:L157	R:R:V185	4.47	No	No	0	3	7
204	R:R:F386	R:R:I158	3.77	Yes	No	0	8	5
205	R:R:F181	R:R:S159	3.96	Yes	Yes	0	8	8
206	R:R:S159	R:R:S381	4.89	Yes	Yes	6	8	8
207	R:R:C385	R:R:S159	6.89	No	Yes	6	9	8
208	R:R:F386	R:R:S159	2.64	Yes	Yes	6	8	8
209	R:R:F181	R:R:L160	3.65	Yes	Yes	0	8	5
210	R:R:F182	R:R:L160	2.44	No	Yes	0	4	5
211	R:R:F163	R:R:I162	2.51	Yes	No	0	7	8
212	R:R:F166	R:R:I162	3.77	Yes	No	0	7	8
213	R:R:C385	R:R:I162	3.27	No	No	0	9	8
214	R:R:F163	R:R:I174	7.54	Yes	No	0	7	9
215	R:R:F163	R:R:K178	2.48	Yes	No	0	7	6
216	R:R:F163	R:R:F181	5.36	Yes	Yes	0	7	8
217	R:R:F164	R:R:K178	23.58	No	No	0	4	6
218	R:R:F166	R:R:I394	3.77	Yes	No	0	7	8
219	R:R:F166	R:R:L395	2.44	Yes	No	0	7	5
220	R:R:F166	R:R:N398	4.83	Yes	No	0	7	5
221	R:R:E390	R:R:L169	3.98	No	No	0	9	9
222	R:R:I394	R:R:L169	4.28	No	No	0	8	9
223	R:R:C171	R:R:I174	3.27	No	No	0	8	9
224	R:R:Q172	R:R:Y236	13.53	Yes	Yes	7	7	8
225	R:R:K249	R:R:Q172	5.42	No	Yes	7	5	7
226	R:R:Q172	R:R:Q250	19.2	Yes	No	7	7	6
227	R:R:L252	R:R:Q172	11.98	No	Yes	0	6	7
228	R:R:I174	R:R:R173	6.26	No	No	0	9	9
229	R:R:H177	R:R:R173	4.51	No	No	0	9	9
230	R:R:L176	R:R:W229	5.69	No	Yes	0	9	9
231	R:R:E233	R:R:L176	3.98	Yes	No	0	9	9
232	R:R:L176	R:R:Y236	4.69	No	Yes	0	9	8
233	R:R:E233	R:R:H177	12.31	Yes	No	0	9	9
234	R:R:N179	R:R:W229	11.3	No	Yes	0	8	9
235	R:R:N179	R:R:Y256	10.47	No	No	0	8	5
236	R:R:F181	R:R:L180	4.87	Yes	Yes	0	8	9
237	R:R:F184	R:R:L180	7.31	Yes	Yes	0	8	9
238	R:R:L180	R:R:W229	7.97	Yes	Yes	0	9	9
239	R:R:E233	R:R:L180	6.63	Yes	Yes	0	9	9
240	R:R:C186	R:R:F182	5.59	No	No	0	7	4
241	R:R:F182	R:R:W260	3.01	No	Yes	0	4	9
242	R:R:C225	R:R:S183	5.16	No	No	12	8	8
243	R:R:N226	R:R:S183	5.96	No	No	0	8	8
244	R:R:S183	R:R:W260	3.71	No	Yes	12	8	9
245	R:R:F184	R:R:N226	21.75	Yes	No	0	8	8
246	R:R:F184	R:R:M230	2.49	Yes	Yes	2	8	9
247	R:R:F184	R:R:Q376	8.2	Yes	Yes	2	8	9
248	R:R:F184	R:R:V380	2.62	Yes	No	0	8	9
249	R:R:N187	R:R:T191	2.92	No	No	0	8	7
250	R:R:M223	R:R:N187	5.61	Yes	No	0	6	8
251	R:R:N187	R:R:N226	12.26	No	No	0	8	8
252	R:R:H219	R:R:V190	4.15	Yes	No	0	6	6
253	R:R:L222	R:R:V190	2.98	No	No	0	5	6
254	R:R:H219	R:R:T191	9.58	Yes	No	0	6	7
255	R:R:H194	R:R:V198	6.92	Yes	No	0	7	6
256	R:R:H194	R:R:S215	6.97	Yes	No	0	7	6
257	R:R:H194	R:R:Q216	8.65	Yes	No	0	7	6
258	R:R:H194	R:R:H219	8.36	Yes	Yes	0	7	6
259	R:R:C212	R:R:V198	3.42	No	No	0	9	6
260	R:R:L204	R:R:N201	8.24	No	No	0	4	4
261	R:R:Q202	R:R:V205	5.73	No	No	0	2	4
262	R:R:L204	R:R:P209	3.28	No	Yes	0	4	5
263	R:R:C282	R:R:V205	6.83	No	No	0	9	4
264	R:R:P209	R:R:T207	3.5	Yes	No	0	5	3
265	R:R:K213	R:R:N208	6.99	No	No	0	8	6
266	R:R:N208	R:R:N281	13.62	No	No	0	6	4
267	R:R:P209	R:R:S211	3.56	Yes	No	0	5	4
268	R:R:C212	R:R:P209	3.77	No	Yes	0	9	5
269	R:R:C212	R:R:C282	7.28	No	No	0	9	9
270	R:R:K213	R:R:W283	26.69	No	No	0	8	8
271	R:R:L220	R:R:Q216	7.99	Yes	No	0	7	6
272	R:R:I284	R:R:Q216	2.74	No	No	0	6	6
273	R:R:F217	R:R:I218	3.77	Yes	No	0	6	5
274	R:R:A267	R:R:F217	4.16	No	Yes	0	6	6
275	R:R:C268	R:R:F217	2.79	No	Yes	0	2	6
276	R:R:A271	R:R:F217	2.77	No	Yes	0	5	6
277	R:R:I218	R:R:L222	2.85	No	No	0	5	5
278	R:R:H219	R:R:M223	3.94	Yes	Yes	2	6	6
279	R:R:H270	R:R:L220	2.57	Yes	Yes	2	8	7
280	R:R:I294	R:R:L220	5.71	No	Yes	2	7	7
281	R:R:L222	R:R:Y221	4.69	No	No	0	5	8
282	R:R:P263	R:R:Y221	8.34	No	No	0	9	8
283	R:R:L264	R:R:Y221	11.72	No	No	0	3	8
284	R:R:M223	R:R:Y227	3.59	Yes	Yes	2	6	8
285	R:R:H295	R:R:M223	3.94	Yes	Yes	2	6	6
286	R:R:G224	R:R:I298	3.53	No	No	0	5	7
287	R:R:C225	R:R:W260	9.14	No	Yes	12	8	9
288	R:R:M230	R:R:Y227	2.39	Yes	Yes	2	9	8
289	R:R:I298	R:R:Y227	14.51	No	Yes	0	7	8
290	R:R:F349	R:R:Y227	4.13	Yes	Yes	2	8	8
291	R:R:M373	R:R:Y227	3.59	Yes	Yes	2	7	8
292	R:R:F228	R:R:L231	3.65	Yes	Yes	4	5	8
293	R:R:F228	R:R:L258	2.44	Yes	Yes	0	5	6
294	R:R:F228	R:R:F262	6.43	Yes	Yes	4	5	4
295	R:R:F228	R:R:P297	2.89	Yes	Yes	4	5	8
296	R:R:A301	R:R:F228	2.77	No	Yes	4	7	5
297	E:E:T130	R:R:F228	5.19	Yes	Yes	4	9	5
298	R:R:C232	R:R:W229	3.92	No	Yes	0	7	9
299	R:R:G259	R:R:W229	2.81	No	Yes	0	9	9
300	R:R:W229	R:R:W260	7.5	Yes	Yes	0	9	9
301	R:R:G346	R:R:M230	3.49	No	Yes	0	9	9
302	R:R:M230	R:R:Q376	2.72	Yes	Yes	2	9	9
303	R:R:I235	R:R:L231	2.85	Yes	Yes	4	6	8
304	R:R:A301	R:R:L231	6.3	No	Yes	4	7	8
305	R:R:L231	R:R:V304	2.98	Yes	No	0	8	6
306	R:R:L231	R:R:N305	6.87	Yes	No	0	8	9
307	E:E:T134	R:R:L231	5.9	No	Yes	4	9	8
308	R:R:C232	R:R:L258	4.76	No	Yes	0	7	6
309	R:R:E233	R:R:L344	14.58	Yes	No	0	9	9
310	R:R:I235	R:R:Y255	4.84	Yes	Yes	0	6	8
311	R:R:F308	R:R:I235	3.77	Yes	Yes	0	8	6
312	E:E:T134	R:R:I235	3.04	No	Yes	4	9	6
313	E:E:V137	R:R:I235	3.07	No	Yes	0	9	6
314	E:E:V138	R:R:I235	6.14	No	Yes	0	9	6
315	R:R:L240	R:R:Y236	8.21	No	Yes	0	8	8
316	R:R:Q250	R:R:Y236	16.91	No	Yes	7	6	8
317	R:R:Y236	R:R:Y255	5.96	Yes	Yes	0	8	8
318	R:R:I241	R:R:L237	2.85	Yes	No	3	8	9
319	R:R:I312	R:R:L237	4.28	No	No	3	9	9
320	R:R:H238	R:R:V242	9.69	Yes	Yes	3	8	6
321	R:R:H238	R:R:V243	2.77	Yes	No	3	8	5
322	R:R:F308	R:R:H238	27.15	Yes	Yes	0	8	8
323	R:R:H238	R:R:N311	7.65	Yes	No	0	8	7
324	E:E:S141	R:R:T239	3.2	No	No	0	9	7
325	R:R:I241	R:R:I312	7.36	Yes	No	3	8	9
326	R:R:V242	R:R:V243	3.21	Yes	No	3	6	5
327	E:E:K142	R:R:V243	6.07	No	No	0	8	5
328	R:R:F246	R:R:V245	3.93	No	No	0	6	7
329	R:R:E248	R:R:K249	2.7	No	No	0	6	5
330	R:R:K249	R:R:Q250	6.78	No	No	7	5	6
331	R:R:H251	R:R:M253	2.63	No	No	0	4	3
332	R:R:H251	R:R:W254	5.29	No	No	0	4	2
333	R:R:L252	R:R:Y255	5.86	No	Yes	0	6	8
334	R:R:L252	R:R:Y256	4.69	No	No	0	6	5
335	E:E:V137	R:R:W254	2.45	No	No	0	9	2
336	E:E:Q140	R:R:W254	16.43	No	No	0	8	2
337	E:E:S141	R:R:Y255	7.63	No	Yes	0	9	8
338	E:E:V133	R:R:L258	2.98	No	Yes	0	7	6
339	E:E:V137	R:R:L258	2.98	No	Yes	0	9	6
340	R:R:G261	R:R:L264	3.42	No	No	0	7	3
341	R:R:F262	R:R:P263	4.33	Yes	No	0	4	9
342	R:R:F262	R:R:I265	2.51	Yes	No	0	4	4
343	E:E:V129	R:R:F262	2.62	No	Yes	0	6	4
344	E:E:T130	R:R:F262	5.19	Yes	Yes	4	9	4
345	E:E:V133	R:R:F262	5.24	No	Yes	0	7	4
346	R:R:I265	R:R:P266	3.39	No	No	0	4	6
347	R:R:H270	R:R:R274	11.28	Yes	Yes	2	8	7
348	R:R:H270	R:R:L290	2.57	Yes	No	2	8	3
349	R:R:H270	R:R:L291	2.57	Yes	No	2	8	5
350	R:R:H270	R:R:I293	6.63	Yes	No	0	8	8
351	R:R:H270	R:R:I294	11.93	Yes	No	2	8	7
352	R:R:A271	R:R:W283	2.59	No	No	0	5	8
353	R:R:I272	R:R:L276	2.85	No	No	0	4	3
354	E:E:F122	R:R:A273	2.77	No	No	0	8	5
355	R:R:R274	R:R:Y278	4.12	Yes	Yes	2	7	6
356	R:R:R274	R:R:W283	18.99	Yes	No	0	7	8
357	R:R:L290	R:R:R274	7.29	No	Yes	2	3	7
358	R:R:L291	R:R:R274	2.43	No	Yes	2	5	7
359	R:R:L276	R:R:S275	3	No	No	0	3	3
360	R:R:L276	R:R:Y277	3.52	No	No	0	3	3
361	E:E:I118	R:R:Y277	13.3	No	No	0	6	3
362	R:R:D280	R:R:Y278	5.75	No	Yes	2	4	6
363	R:R:S285	R:R:Y278	10.17	Yes	Yes	2	5	6
364	R:R:D287	R:R:Y278	3.45	No	Yes	2	3	6
365	R:R:T288	R:R:Y278	9.99	Yes	Yes	2	5	6
366	E:E:V111	R:R:Y278	8.83	No	Yes	0	5	6
367	E:E:D113	R:R:Y278	4.6	No	Yes	2	9	6
368	R:R:D280	R:R:N281	4.04	No	No	0	4	4
369	R:R:D280	R:R:S285	5.89	No	Yes	2	4	5
370	R:R:C282	R:R:I284	3.27	No	No	0	9	6
371	R:R:D287	R:R:S285	4.42	No	Yes	2	3	5
372	R:R:S285	R:R:T288	4.8	Yes	Yes	2	5	5
373	R:R:L290	R:R:T288	4.42	No	Yes	2	3	5
374	E:E:D113	R:R:T288	8.67	No	Yes	2	9	5
375	R:R:H289	R:R:Y292	8.71	No	No	0	4	6
376	E:E:I123	R:R:I293	2.94	No	No	0	9	8
377	R:R:G296	R:R:P297	4.06	No	Yes	0	4	8
378	E:E:P126	R:R:P297	3.9	No	Yes	0	9	8
379	E:E:I127	R:R:P297	5.08	No	Yes	0	6	8
380	E:E:T130	R:R:P297	6.99	Yes	Yes	4	9	8
381	R:R:F349	R:R:L302	3.65	Yes	No	0	8	7
382	R:R:L302	R:R:V350	7.45	No	No	0	7	6
383	R:R:F308	R:R:V304	5.24	Yes	No	0	8	6
384	R:R:L345	R:R:N305	15.1	Yes	No	0	9	9
385	R:R:L306	R:R:L310	2.77	No	No	0	5	5
386	R:R:I347	R:R:L306	2.85	Yes	No	0	7	5
387	R:R:F307	R:R:F308	4.29	No	Yes	0	4	8
388	R:R:F307	R:R:N311	8.46	No	No	0	4	7
389	R:R:L309	R:R:V313	2.98	Yes	No	0	9	6
390	R:R:L309	R:R:L341	4.15	Yes	No	0	9	9
391	R:R:L309	R:R:L345	4.15	Yes	Yes	13	9	9
392	R:R:I347	R:R:L309	2.85	Yes	Yes	13	7	9
393	R:R:N311	R:R:R314	6.03	No	No	0	7	7
394	R:R:I317	R:R:V313	3.07	No	No	0	5	6
395	R:R:T338	R:R:V313	3.17	No	No	0	9	6
396	R:R:T318	R:R:V315	3.17	No	Yes	3	7	8
397	R:R:K319	R:R:V315	3.04	No	Yes	3	9	8
398	R:R:L316	R:R:L320	4.15	No	No	0	8	7
399	R:R:I317	R:R:K321	4.36	No	No	0	5	6
400	R:R:K319	R:R:T318	3	No	No	3	9	7
401	R:R:L320	R:R:L330	2.77	No	No	0	7	6
402	R:R:K333	R:R:L320	7.05	No	No	0	8	7
403	R:R:K321	R:R:L330	2.82	No	No	0	6	6
404	R:R:L330	R:R:N329	2.75	No	No	0	6	5
405	R:R:V335	R:R:Y331	3.79	No	No	0	8	7
406	R:R:L339	R:R:V335	2.98	No	No	0	7	8
407	R:R:I340	R:R:R336	7.52	No	No	0	8	8
408	R:R:F384	R:R:I340	2.51	No	No	0	8	8
409	R:R:P343	R:R:V342	3.53	No	No	0	9	8
410	R:R:I347	R:R:V342	10.75	Yes	No	0	7	8
411	R:R:E348	R:R:V342	4.28	Yes	No	0	8	8
412	R:R:L379	R:R:P343	8.21	No	No	0	5	9
413	R:R:I383	R:R:P343	3.39	No	No	0	7	9
414	R:R:L344	R:R:L345	2.77	No	Yes	0	9	9
415	R:R:F384	R:R:L344	10.96	No	No	0	8	9
416	R:R:I347	R:R:L345	4.28	Yes	Yes	13	7	9
417	R:R:E348	R:R:G346	4.91	Yes	No	0	8	9
418	R:R:E348	R:R:F349	9.33	Yes	Yes	2	8	8
419	R:R:E348	R:R:L372	6.63	Yes	No	0	8	6
420	R:R:E348	R:R:Q376	6.37	Yes	Yes	2	8	9
421	R:R:F349	R:R:M373	7.46	Yes	Yes	2	8	7
422	R:R:F349	R:R:Q376	10.54	Yes	Yes	2	8	9
423	R:R:I352	R:R:L351	4.28	No	No	0	7	5
424	R:R:E363	R:R:W354	3.27	No	No	8	4	5
425	R:R:W354	R:R:Y365	10.61	No	Yes	8	5	6
426	R:R:E363	R:R:Y365	5.61	No	Yes	8	4	6
427	R:R:I368	R:R:V364	4.61	No	No	0	4	4
428	R:R:M369	R:R:Y365	10.78	No	Yes	0	8	6
429	R:R:D366	R:R:H370	10.08	No	Yes	2	6	7
430	R:R:H370	R:R:H374	9.55	Yes	Yes	2	7	9
431	R:R:F375	R:R:I371	5.02	No	No	0	7	6
432	R:R:H374	R:R:M373	6.57	Yes	Yes	2	9	7
433	R:R:F386	R:R:S381	2.64	Yes	Yes	6	8	8
434	R:R:F386	R:R:T382	5.19	Yes	No	0	8	5
435	R:R:F387	R:R:T382	2.59	No	No	0	5	5
436	R:R:F384	R:R:I383	8.79	No	No	0	8	7
437	R:R:C385	R:R:F386	4.19	No	Yes	6	9	8
438	R:R:N388	R:R:V391	5.91	No	No	0	9	9
439	R:R:L395	R:R:V391	2.98	No	No	0	5	9
440	R:R:Q392	R:R:R396	10.51	No	No	0	7	5
441	R:R:I394	R:R:R397	2.51	No	No	0	8	7
442	E:E:L36	E:E:Y32	16.41	Yes	Yes	1	7	7
443	E:E:M76	E:E:Y32	7.18	Yes	Yes	1	6	7
444	E:E:A77	E:E:Y32	4	No	Yes	0	9	7
445	E:E:L80	E:E:Y32	7.03	Yes	Yes	1	5	7
446	E:E:V89	E:E:Y32	3.79	No	Yes	0	9	7
447	E:E:G33	E:E:L36	5.13	No	Yes	0	4	7
448	E:E:G33	E:E:R37	3	No	No	0	4	4
449	E:E:E88	E:E:G33	4.91	No	No	0	4	4
450	E:E:L35	E:E:L80	4.15	No	Yes	0	3	5
451	E:E:L36	E:E:T73	2.95	Yes	Yes	1	7	9
452	E:E:L36	E:E:M76	2.83	Yes	Yes	1	7	6
453	E:E:L41	E:E:R37	2.43	No	No	0	7	4
454	E:E:E38	E:E:L39	2.65	No	No	0	4	2
455	E:E:L39	E:E:M76	5.65	No	Yes	0	2	6
456	E:E:C40	E:E:C72	7.28	No	No	0	9	9
457	E:E:C40	E:E:T73	3.38	No	Yes	0	9	9
458	E:E:L41	E:E:Q45	10.65	No	No	0	7	4
459	E:E:F92	E:E:L41	9.74	Yes	No	0	8	7
460	E:E:D47	E:E:Q43	10.44	No	No	0	6	4
461	E:E:F44	E:E:M48	11.2	Yes	Yes	1	9	9
462	E:E:F44	E:E:S65	2.64	Yes	No	1	9	5
463	E:E:F44	E:E:L69	19.49	Yes	Yes	1	9	8
464	E:E:F44	E:E:V96	3.93	Yes	No	1	9	7
465	E:E:F44	E:E:Y100	5.16	Yes	Yes	1	9	9
466	E:E:Q45	E:E:Y100	5.64	No	Yes	0	4	9
467	E:E:D47	E:E:R64	4.76	No	No	0	6	3
468	E:E:M48	E:E:W56	6.98	Yes	Yes	1	9	9
469	E:E:M48	E:E:S65	3.07	Yes	No	1	9	5
470	E:E:M48	E:E:Y100	9.58	Yes	Yes	1	9	9
471	E:E:F101	E:E:M48	2.49	Yes	Yes	1	9	9
472	E:E:V51	E:E:W56	2.45	No	Yes	0	6	9
473	E:E:R61	E:E:V51	5.23	No	No	0	5	6
474	E:E:E53	E:E:W56	14.17	No	Yes	0	4	9
475	E:E:L55	E:E:T54	2.95	No	No	0	4	3
476	E:E:L55	E:E:R61	4.86	No	No	0	4	5
477	E:E:W56	E:E:Y100	10.61	Yes	Yes	1	9	9
478	E:E:C104	E:E:C57	7.28	Yes	No	1	9	9
479	E:E:C57	E:E:P105	3.77	No	No	0	9	6
480	E:E:D58	E:E:R61	3.57	No	No	0	7	5
481	E:E:T62	E:E:W59	4.85	No	Yes	0	9	9
482	E:E:I63	E:E:W59	15.27	No	Yes	0	4	9
483	E:E:W59	E:E:Y66	6.75	Yes	Yes	1	9	9
484	E:E:R109	E:E:W59	11	Yes	Yes	1	9	9
485	E:E:F101	E:E:T62	7.78	Yes	No	0	9	9
486	E:E:R64	E:E:S65	6.59	No	No	0	3	5
487	E:E:H97	E:E:Y66	11.98	Yes	Yes	1	9	9
488	E:E:F92	E:E:L69	4.87	Yes	Yes	1	8	8
489	E:E:F93	E:E:L69	4.87	Yes	Yes	1	9	8
490	E:E:L69	E:E:V96	2.98	Yes	No	1	8	7
491	E:E:A70	E:E:F93	2.77	No	Yes	0	8	9
492	E:E:T73	E:E:W84	3.64	Yes	Yes	1	9	9
493	E:E:F92	E:E:T73	2.59	Yes	Yes	1	8	9
494	E:E:F93	E:E:T73	5.19	Yes	Yes	1	9	9
495	E:E:H75	E:E:W74	8.46	No	No	0	4	1
496	E:E:E78	E:E:W74	10.9	No	No	0	1	1
497	E:E:W74	E:E:W84	10.31	No	Yes	0	1	9
498	E:E:L80	E:E:M76	2.83	Yes	Yes	1	5	6
499	E:E:A77	E:E:W84	3.89	No	Yes	0	9	9
500	E:E:P85	E:E:W84	13.51	No	Yes	1	9	9
501	E:E:V89	E:E:W84	6.13	No	Yes	0	9	9
502	E:E:N86	E:E:V89	5.91	No	No	0	8	9
503	E:E:F92	E:E:F93	5.36	Yes	Yes	1	8	9
504	E:E:F92	E:E:V96	5.24	Yes	No	1	8	7
505	E:E:F101	E:E:H97	9.05	Yes	Yes	1	9	9
506	E:E:G98	E:E:R102	4.5	No	No	0	3	4
507	E:E:R99	E:E:Y100	10.29	No	Yes	0	3	9
508	E:E:F101	E:E:Y100	3.09	Yes	Yes	1	9	9
509	E:E:C104	E:E:F101	2.79	Yes	Yes	1	9	9
510	E:E:P105	E:E:R109	10.09	No	Yes	0	6	9
511	E:E:G108	E:E:S107	3.71	No	No	0	9	7
512	E:E:D113	E:E:P114	4.83	No	Yes	0	9	9
513	E:E:L119	E:E:P114	8.21	No	Yes	0	9	9
514	E:E:F122	E:E:I118	2.51	No	No	0	8	6
515	E:E:P126	E:E:V125	3.53	No	No	0	9	6
516	E:E:L132	E:E:V133	2.98	No	No	0	7	7
517	E:E:R143	E:E:W139	4	No	No	0	6	9
518	E:E:Q140	E:E:R143	8.18	No	No	0	8	6
519	E:E:E88	E:E:R91	2.33	No	No	0	4	3
520	R:R:L395	R:R:W399	2.28	No	No	0	5	5
521	L:L:G20	L:L:G21	2.11	No	No	0	0	0
522	L:L:A13	L:L:G14	1.95	No	No	0	0	0
523	E:E:P114	E:E:P115	1.95	Yes	No	0	9	9
524	E:E:G52	E:E:V51	1.84	No	No	0	6	6
525	R:R:G81	R:R:T82	1.82	No	No	0	7	5
526	L:L:A13	R:R:A199	1.79	No	No	0	0	4
527	R:R:A244	R:R:A247	1.79	No	No	0	6	6
528	L:L:G14	R:R:I284	1.76	No	No	0	0	6
529	E:E:G60	E:E:I63	1.76	No	No	0	3	4
530	E:E:G98	R:R:M53	1.75	No	Yes	0	3	2
531	E:E:C57	E:E:S103	1.72	No	No	1	9	5
532	E:E:C104	E:E:S103	1.72	Yes	No	1	9	5
533	R:R:G161	R:R:L160	1.71	No	Yes	0	1	5
534	R:R:G234	R:R:L345	1.71	No	Yes	0	8	9
535	E:E:G116	E:E:L119	1.71	No	No	0	4	9
536	L:L:A5	L:L:V8	1.7	No	Yes	0	0	0
537	L:L:G33	L:L:N31	1.7	No	No	0	0	0
538	R:R:G389	R:R:N388	1.7	No	No	0	6	9
539	R:R:I352	R:R:P353	1.69	No	No	0	7	6
540	E:E:I118	E:E:P114	1.69	No	Yes	0	6	9
541	R:R:A79	R:R:T82	1.68	No	No	0	1	5
542	R:R:A244	R:R:T239	1.68	No	No	0	6	7
543	E:E:T130	R:R:A300	1.68	Yes	No	0	9	3
544	R:R:G389	R:R:Q392	1.64	No	No	0	6	7
545	L:L:S19	L:L:V22	1.62	No	No	0	0	0
546	L:L:P29	R:R:D94	1.61	No	Yes	0	0	5
547	R:R:V189	R:R:V190	1.6	No	No	0	4	6
548	R:R:V210	R:R:V214	1.6	No	No	0	4	4
549	R:R:V242	R:R:V315	1.6	Yes	Yes	3	6	8
550	L:L:V22	R:R:T131	1.59	No	No	0	0	1
551	R:R:T131	R:R:V135	1.59	No	Yes	0	1	1
552	R:R:G148	R:R:H374	1.59	No	Yes	0	9	9
553	E:E:C82	E:E:L80	1.59	No	Yes	0	9	5
554	E:E:T128	E:E:V129	1.59	No	No	0	6	6
555	L:L:L15	R:R:A138	1.58	No	No	0	0	5
556	L:L:L16	R:R:A138	1.58	No	No	0	0	5
557	R:R:A337	R:R:L316	1.58	No	No	0	9	8
558	L:L:T9	R:R:T191	1.57	No	No	0	0	7
559	R:R:I218	R:R:V214	1.54	No	No	0	5	4
560	R:R:I241	R:R:V242	1.54	Yes	Yes	3	8	6
561	R:R:I241	R:R:V315	1.54	Yes	Yes	3	8	8
562	R:R:I312	R:R:V242	1.54	No	Yes	3	9	6
563	R:R:A206	R:R:Q33	1.52	No	No	0	4	4
564	R:R:K40	R:R:V36	1.52	No	No	0	5	2
565	E:E:C82	E:E:E29	1.52	No	No	0	9	4
566	R:R:M85	R:R:T102	1.51	No	No	0	4	5
567	R:R:L169	R:R:S168	1.5	No	No	0	9	7
568	R:R:K178	R:R:T175	1.5	No	No	0	6	6
569	E:E:G108	E:E:R112	1.5	No	No	0	9	4
570	R:R:L156	R:R:V185	1.49	Yes	No	0	9	7
571	R:R:L160	R:R:V185	1.49	Yes	No	0	5	7
572	E:E:L131	R:R:V304	1.49	No	No	0	9	6
573	R:R:N128	R:R:V129	1.48	No	No	0	3	2
574	R:R:L34	R:R:T37	1.47	No	No	0	2	4
575	R:R:I192	R:R:I193	1.47	No	No	0	6	5
576	R:R:I269	R:R:I293	1.47	No	No	0	5	8
577	E:E:I106	R:R:K51	1.45	No	No	0	4	3
578	R:R:I147	R:R:L151	1.43	No	No	0	5	5
579	R:R:I368	R:R:L372	1.43	No	No	0	4	6
580	R:R:L87	R:R:M85	1.41	No	No	0	4	4
581	E:E:K79	E:E:L80	1.41	No	Yes	0	3	5
582	R:R:K213	R:R:N279	1.4	No	No	0	8	6
583	R:R:P353	R:R:Y365	1.39	No	Yes	0	6	6
584	E:E:P121	E:E:Y120	1.39	No	No	0	8	6
585	R:R:A393	R:R:R397	1.38	No	No	0	4	7
586	E:E:A34	E:E:R37	1.38	No	No	0	2	4
587	E:E:E29	E:E:N31	1.31	No	No	0	4	1
588	E:E:D71	E:E:H75	1.26	No	No	0	8	4
589	R:R:F142	R:R:N200	1.21	Yes	No	0	6	3
590	R:R:I146	R:R:Y143	1.21	Yes	No	0	6	4
591	E:E:I123	E:E:Y120	1.21	No	No	0	9	6
592	L:L:D3	R:R:R355	1.19	No	No	0	0	4
593	R:R:K40	R:R:Y91	1.19	No	Yes	0	5	5
594	E:E:E68	E:E:R64	1.16	No	No	0	4	3
595	E:E:L136	E:E:W139	1.14	No	No	0	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:C7	5.465	4	2	0
2	L:L:V8	4.6025	4	0	0
3	L:L:H10	4.68	6	2	0
4	L:L:L12	4.3175	4	2	0
5	L:L:T30	8.2875	4	1	0
6	L:L:V32	3.555	4	0	0
7	L:L:F37	4.2325	4	1	0
8	R:R:M42	2.835	4	0	3
9	R:R:Q45	7.91	5	1	5
10	R:R:Y46	10.7057	7	1	2
11	R:R:Y49	7.16167	6	1	3
12	R:R:I52	4.4325	4	1	5
13	R:R:M53	3.346	5	1	2
14	R:R:W69	7.575	6	1	7
15	R:R:D70	7.65	4	1	9
16	R:R:W72	8.40833	6	1	5
17	R:R:L73	7.02	6	1	5
18	R:R:W75	6.84167	6	1	9
19	R:R:Y91	5.31833	6	1	5
20	R:R:F92	7.068	5	1	6
21	R:R:D94	5.2	6	1	5
22	R:R:F95	5.65833	6	1	5
23	R:R:D96	7.1675	4	0	5
24	R:R:E99	5.31	4	0	5
25	R:R:W111	9.342	5	1	9
26	R:R:H114	10.8225	4	5	4
27	R:R:T122	10.32	4	1	7
28	R:R:Y124	9.43429	7	1	4
29	R:R:T125	4.6675	4	5	6
30	R:R:V135	3.1525	4	9	1
31	R:R:L141	6.73	5	2	6
32	R:R:F142	4.35333	6	2	6
33	R:R:I146	3.6825	4	2	6
34	R:R:L156	3.748	5	0	9
35	R:R:S159	4.595	4	6	8
36	R:R:L160	2.3225	4	0	5
37	R:R:F163	4.4725	4	0	7
38	R:R:F166	3.7025	4	0	7
39	R:R:Q172	12.5325	4	7	7
40	R:R:L180	6.695	4	0	9
41	R:R:F181	5.03	5	0	8
42	R:R:F184	7.46833	6	2	8
43	R:R:H194	7.725	4	0	7
44	R:R:P209	3.5275	4	0	5
45	R:R:F217	3.3725	4	0	6
46	R:R:H219	6.162	5	2	6
47	R:R:L220	4.71	4	2	7
48	R:R:M223	4.73	5	2	6
49	R:R:Y227	5.642	5	2	8
50	R:R:F228	3.895	6	4	5
51	R:R:W229	6.53167	6	0	9
52	R:R:M230	2.7725	4	2	9
53	R:R:L231	4.75833	6	4	8
54	R:R:E233	9.375	4	0	9
55	R:R:I235	3.95167	6	4	6
56	R:R:Y236	9.86	5	7	8
57	R:R:H238	11.815	4	3	8
58	R:R:I241	3.3225	4	3	8
59	R:R:V242	3.516	5	3	6
60	R:R:Y255	6.0725	4	0	8
61	R:R:L258	3.29	4	0	6
62	R:R:W260	5.84	4	12	9
63	R:R:F262	4.38667	6	4	4
64	R:R:H270	6.25833	6	2	8
65	R:R:R274	8.822	5	2	7
66	R:R:Y278	6.70143	7	2	6
67	R:R:S285	6.32	4	2	5
68	R:R:T288	6.97	4	2	5
69	R:R:H295	6.3325	4	2	6
70	R:R:P297	4.584	5	4	8
71	R:R:F308	10.1125	4	0	8
72	R:R:L309	3.5325	4	13	9
73	R:R:V315	2.3375	4	3	8
74	R:R:L345	5.602	5	13	9
75	R:R:I347	5.1825	4	13	7
76	R:R:E348	6.304	5	2	8
77	R:R:F349	7.022	5	2	8
78	R:R:Y365	7.0975	4	8	6
79	R:R:H370	7.85714	7	2	7
80	R:R:M373	5.545	4	2	7
81	R:R:H374	9.252	5	2	9
82	R:R:Q376	6.9575	4	2	9
83	R:R:S381	4.6375	4	6	8
84	R:R:F386	3.51167	6	6	8
85	E:E:Y32	7.682	5	1	7
86	E:E:L36	6.83	4	1	7
87	E:E:F44	8.484	5	1	9
88	E:E:M48	6.664	5	1	9
89	E:E:W56	8.5525	4	1	9
90	E:E:W59	10.4183	6	1	9
91	E:E:Y66	7.05	4	1	9
92	E:E:L69	8.0525	4	1	8
93	E:E:T73	3.55	5	1	9
94	E:E:M76	4.6225	4	1	6
95	E:E:L80	3.402	5	1	5
96	E:E:W84	6.915	6	1	9
97	E:E:F92	5.56	5	1	8
98	E:E:F93	5.53167	6	1	9
99	E:E:H97	7.51333	6	1	9
100	E:E:Y100	7.395	6	1	9
101	E:E:F101	6.26333	6	1	9
102	E:E:C104	3.62	4	1	9
103	E:E:R109	10.5175	4	1	9
104	E:E:P114	4.17	4	0	9
105	E:E:T130	4.7625	4	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V8	R:R:H370	27.7243	6.92	Yes	Yes	0	0	7
2	L:L:V8	R:R:M373	26.7603	4.56	Yes	Yes	0	0	7
3	L:L:H10	R:R:M223	24.1017	6.57	Yes	Yes	2	0	6
4	L:L:H10	R:R:L291	32.4354	2.57	Yes	No	2	0	5
5	L:L:L12	R:R:H370	55.0335	5.14	Yes	Yes	2	0	7
6	L:L:L12	L:L:L16	54.8864	5.54	Yes	No	2	0	0
7	L:L:L16	R:R:A138	55.8053	1.58	No	No	0	0	5
8	L:L:L15	R:R:A138	55.8303	1.58	No	No	0	0	5
9	L:L:L15	R:R:K134	56.0715	2.82	No	No	0	0	3
10	R:R:L291	R:R:R274	32.2586	2.43	No	Yes	2	5	7
11	R:R:R274	R:R:Y278	42.5521	4.12	Yes	Yes	2	7	6
12	R:R:D287	R:R:Y278	43.4424	3.45	No	Yes	2	3	6
13	L:L:R18	R:R:D287	43.9724	2.38	No	No	0	0	3
14	L:L:R18	R:R:P97	44.0623	4.32	No	No	0	0	3
15	R:R:D96	R:R:P97	44.1091	6.44	Yes	No	0	5	3
16	R:R:D96	R:R:E99	100	3.9	Yes	Yes	0	5	5
17	R:R:C88	R:R:E99	98.2967	3.04	No	Yes	0	9	5
18	R:R:C127	R:R:C88	61.764	7.28	No	No	0	9	9
19	R:R:C127	R:R:F95	35.3376	4.19	No	Yes	0	9	5
20	R:R:D96	R:R:K134	56.025	12.44	Yes	No	0	5	3
21	R:R:C88	R:R:V101	36.5338	3.42	No	No	0	9	7
22	R:R:V101	R:R:Y124	26.4199	11.36	No	Yes	1	7	4
23	R:R:W72	R:R:Y124	52.0326	23.15	Yes	Yes	1	5	4
24	R:R:C127	R:R:Y124	26.4348	2.69	No	Yes	0	9	4
25	R:R:F95	R:R:W72	26.251	6.01	Yes	Yes	1	5	5
26	L:L:F37	R:R:W72	51.2969	7.02	Yes	Yes	1	0	5
27	L:L:F37	R:R:G71	19.087	3.01	Yes	No	0	0	4
28	E:E:W84	L:L:F37	31.764	4.01	Yes	Yes	1	9	0
29	R:R:L73	R:R:V101	10.0691	4.47	Yes	No	1	5	7
30	R:R:I41	R:R:Y91	11.8022	4.84	No	Yes	0	6	5
31	R:R:W72	R:R:Y91	26.8485	4.82	Yes	Yes	1	5	5
32	R:R:A44	R:R:Y91	31.8502	2.67	No	Yes	0	6	5
33	R:R:A44	R:R:W69	31.4666	2.59	No	Yes	0	6	7
34	R:R:Q45	R:R:W69	11.9526	18.62	Yes	Yes	1	5	7
35	R:R:G71	R:R:W69	18.8545	7.04	No	Yes	0	4	7
36	E:E:Y66	R:R:Q45	18.4554	4.51	Yes	Yes	1	9	5
37	R:R:W69	R:R:Y49	30.2229	6.75	Yes	Yes	1	7	3
38	E:E:H97	R:R:Y49	26.571	8.71	Yes	Yes	1	9	3
39	E:E:T73	E:E:W84	25.1597	3.64	Yes	Yes	1	9	9
40	E:E:F101	E:E:H97	15.1993	9.05	Yes	Yes	1	9	9
41	R:R:H370	R:R:H374	27.1248	9.55	Yes	Yes	2	7	9
42	R:R:H374	R:R:M373	26.8474	6.57	Yes	Yes	2	9	7
43	R:R:M223	R:R:N187	13.7298	5.61	Yes	No	0	6	8
44	R:R:N187	R:R:N226	13.9462	12.26	No	No	0	8	8
45	R:R:F184	R:R:N226	10.7712	21.75	Yes	No	0	8	8
46	R:R:F184	R:R:L156	22.3394	2.44	Yes	Yes	0	8	9
47	R:R:M223	R:R:Y227	11.3377	3.59	Yes	Yes	2	6	8
48	R:R:M230	R:R:Y227	30.977	2.39	Yes	Yes	2	9	8
49	R:R:F184	R:R:M230	30.491	2.49	Yes	Yes	2	8	9
50	R:R:M373	R:R:Y227	21.071	3.59	Yes	Yes	2	7	8
51	R:R:F349	R:R:M373	32.3807	7.46	Yes	Yes	2	8	7
52	R:R:F349	R:R:Q376	20.2039	10.54	Yes	Yes	2	8	9
53	R:R:F184	R:R:Q376	20.1128	8.2	Yes	Yes	2	8	9
54	R:R:F181	R:R:L156	13.7272	7.31	Yes	Yes	0	8	9
55	R:R:F184	R:R:L180	38.0804	7.31	Yes	Yes	0	8	9
56	R:R:F181	R:R:L180	14.095	4.87	Yes	Yes	0	8	9
57	R:R:F163	R:R:F181	22.4254	5.36	Yes	Yes	0	7	8
58	R:R:F163	R:R:I162	16.3294	2.51	Yes	No	0	7	8
59	R:R:F166	R:R:I162	15.3143	3.77	Yes	No	0	7	8
60	R:R:L176	R:R:Y236	14.5485	4.69	No	Yes	0	9	8
61	R:R:L180	R:R:W229	15.0845	7.97	Yes	Yes	0	9	9
62	R:R:L222	R:R:Y221	13.9904	4.69	No	No	0	5	8
63	R:R:P263	R:R:Y221	13.4982	8.34	No	No	0	9	8
64	R:R:F262	R:R:P263	13.3408	4.33	Yes	No	0	4	9
65	R:R:E348	R:R:F349	11.9381	9.33	Yes	Yes	2	8	8
66	R:R:E348	R:R:V342	11.1548	4.28	Yes	No	0	8	8
67	E:E:F92	E:E:T73	15.9475	2.59	Yes	Yes	1	8	9
68	E:E:F44	E:E:L69	11.9655	19.49	Yes	Yes	1	9	8
69	E:E:M48	E:E:W56	10.7835	6.98	Yes	Yes	1	9	9
70	E:E:W56	E:E:Y100	12.6928	10.61	Yes	Yes	1	9	9
71	E:E:V51	E:E:W56	17.608	2.45	No	Yes	0	6	9
72	E:E:R61	E:E:V51	11.7392	5.23	No	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C2	R:R:Y292	4.03	2	No	No	0	6	0	1
L:L:D3	R:R:W354	8.93	0	No	No	0	5	0	1
L:L:A5	R:R:M369	4.83	0	No	No	0	8	0	1
L:L:T6	R:R:H295	6.85	0	No	Yes	0	6	0	1
L:L:T6	R:R:C299	3.38	0	No	No	0	4	0	1
L:L:C7	R:R:H295	7.37	2	Yes	Yes	0	6	0	1
L:L:V8	R:R:H370	6.92	0	Yes	Yes	0	7	0	1
L:L:V8	R:R:M373	4.56	0	Yes	Yes	0	7	0	1
L:L:H10	R:R:H219	4.78	2	Yes	Yes	0	6	0	1
L:L:H10	R:R:L220	2.57	2	Yes	Yes	0	7	0	1
L:L:H10	R:R:M223	6.57	2	Yes	Yes	0	6	0	1
L:L:H10	R:R:L291	2.57	2	Yes	No	0	5	0	1
L:L:H10	R:R:H295	7.17	2	Yes	Yes	0	6	0	1
L:L:L12	R:R:F142	2.44	2	Yes	Yes	0	6	0	1
L:L:L12	R:R:L195	4.15	2	Yes	No	0	7	0	1
L:L:L12	R:R:H370	5.14	2	Yes	Yes	0	7	0	1
L:L:G14	R:R:S286	3.71	0	No	No	0	7	0	1
L:L:L15	R:R:K134	2.82	0	No	No	0	3	0	1
L:L:L16	R:R:F142	4.87	2	No	Yes	0	6	0	1
L:L:S17	R:R:V205	4.85	0	No	No	0	4	0	1
L:L:R18	R:R:D90	7.15	0	No	No	0	3	0	1
L:L:R18	R:R:P97	4.32	0	No	No	0	3	0	1
L:L:R18	R:R:D287	2.38	0	No	No	0	3	0	1
L:L:S19	R:R:V135	3.23	0	No	Yes	0	1	0	1
L:L:G21	R:R:Q93	3.29	0	No	No	0	4	0	1
L:L:V23	R:R:H132	2.77	9	No	No	0	2	0	1
L:L:V23	R:R:V135	4.81	9	No	Yes	0	1	0	1
L:L:V23	R:R:L139	2.98	9	No	No	0	3	0	1
L:L:F27	R:R:Q93	4.68	0	No	No	0	4	0	1
L:L:F27	R:R:D94	8.36	0	No	Yes	0	5	0	1
L:L:T30	R:R:W72	2.43	1	Yes	Yes	0	5	0	1
L:L:T30	R:R:F92	14.27	1	Yes	Yes	0	6	0	1
L:L:T30	R:R:D94	8.67	1	Yes	Yes	0	5	0	1
L:L:T30	R:R:F95	7.78	1	Yes	Yes	0	5	0	1
L:L:V32	R:R:F95	2.62	0	Yes	Yes	0	5	0	1
L:L:V32	R:R:Y124	2.52	0	Yes	Yes	0	4	0	1
L:L:V32	R:R:T125	3.17	0	Yes	Yes	0	6	0	1
L:L:V32	R:R:N128	5.91	0	Yes	No	0	3	0	1
L:L:S34	R:R:H114	15.34	5	No	Yes	0	4	0	1
L:L:S34	R:R:A116	3.42	5	No	No	0	3	0	1
L:L:S34	R:R:S117	4.89	5	No	No	0	4	0	1
L:L:F37	R:R:G71	3.01	1	Yes	No	0	4	0	1
L:L:F37	R:R:W72	7.02	1	Yes	Yes	0	5	0	1
E:E:W84	L:L:F37	4.01	1	Yes	Yes	9	0	1	0
E:E:P85	L:L:F37	2.89	1	No	Yes	9	0	1	0
R:R:G71	R:R:W69	7.04	0	No	Yes	4	7	1	2
R:R:D70	R:R:L73	2.71	1	Yes	Yes	9	5	2	2
R:R:D70	R:R:T122	8.67	1	Yes	Yes	9	7	2	2
R:R:D70	R:R:Y124	8.05	1	Yes	Yes	9	4	2	1
R:R:W72	R:R:Y91	4.82	1	Yes	Yes	5	5	1	2
R:R:F92	R:R:W72	7.02	1	Yes	Yes	6	5	1	1
R:R:F95	R:R:W72	6.01	1	Yes	Yes	5	5	1	1
R:R:W72	R:R:Y124	23.15	1	Yes	Yes	5	4	1	1
R:R:L73	R:R:V101	4.47	1	Yes	No	5	7	2	2
R:R:L73	R:R:Y124	7.03	1	Yes	Yes	5	4	2	1
R:R:F92	R:R:Y91	3.09	1	Yes	Yes	6	5	1	2
R:R:D94	R:R:F92	2.39	1	Yes	Yes	5	6	1	1
R:R:F92	R:R:F95	8.57	1	Yes	Yes	6	5	1	1
R:R:D94	R:R:F95	4.78	1	Yes	Yes	5	5	1	1
R:R:D94	R:R:N128	5.39	1	Yes	No	5	3	1	1
R:R:C127	R:R:F95	4.19	0	No	Yes	9	5	2	1
R:R:D96	R:R:P97	6.44	0	Yes	No	5	3	2	1
R:R:D96	R:R:K134	12.44	0	Yes	No	5	3	2	1
R:R:V101	R:R:Y124	11.36	1	No	Yes	7	4	2	1
R:R:H114	R:R:P115	9.15	5	Yes	No	4	3	1	2
R:R:A116	R:R:H114	2.93	5	No	Yes	3	4	1	1
R:R:H114	R:R:W121	15.87	5	Yes	No	4	8	1	2
R:R:R119	R:R:S117	5.27	0	No	No	4	4	2	1
R:R:N123	R:R:W121	13.56	5	No	No	8	8	2	2
R:R:T125	R:R:W121	2.43	5	Yes	No	6	8	1	2
R:R:T122	R:R:Y124	11.24	1	Yes	Yes	7	4	2	1
R:R:N123	R:R:T125	10.24	5	No	Yes	8	6	2	1
R:R:C127	R:R:Y124	2.69	0	No	Yes	9	4	2	1
R:R:Q126	R:R:T125	2.83	0	No	Yes	5	6	2	1
R:R:E133	R:R:K134	2.7	0	No	No	1	3	2	1
R:R:L139	R:R:V135	2.98	9	No	Yes	3	1	1	1
R:R:L141	R:R:L144	2.77	2	Yes	No	6	6	2	2
R:R:D366	R:R:L141	4.07	2	No	Yes	6	6	2	2
R:R:H370	R:R:L141	18	2	Yes	Yes	7	6	1	2
R:R:F142	R:R:I146	7.54	2	Yes	Yes	6	6	1	2
R:R:F142	R:R:L195	4.87	2	Yes	No	6	7	1	1
R:R:F142	R:R:T196	5.19	2	Yes	No	6	3	1	2
R:R:H370	R:R:L144	2.57	2	Yes	No	7	6	1	2
R:R:H370	R:R:T145	2.74	2	Yes	No	7	7	1	2
R:R:H374	R:R:T145	17.8	2	Yes	No	9	7	2	2
R:R:I146	R:R:T196	3.04	2	Yes	No	6	3	2	2
R:R:N187	R:R:T191	2.92	0	No	No	8	7	2	1
R:R:M223	R:R:N187	5.61	2	Yes	No	6	8	1	2
R:R:H219	R:R:V190	4.15	2	Yes	No	6	6	1	2
R:R:H219	R:R:T191	9.58	2	Yes	No	6	7	1	1
R:R:H194	R:R:Q216	8.65	0	Yes	No	7	6	2	2
R:R:H194	R:R:H219	8.36	0	Yes	Yes	7	6	2	1
R:R:Q202	R:R:V205	5.73	0	No	No	2	4	2	1
R:R:C282	R:R:V205	6.83	0	No	No	9	4	2	1
R:R:L220	R:R:Q216	7.99	2	Yes	No	7	6	1	2
R:R:I284	R:R:Q216	2.74	0	No	No	6	6	1	2
R:R:H219	R:R:M223	3.94	2	Yes	Yes	6	6	1	1
R:R:H270	R:R:L220	2.57	2	Yes	Yes	8	7	2	1
R:R:I294	R:R:L220	5.71	2	No	Yes	7	7	2	1
R:R:M223	R:R:Y227	3.59	2	Yes	Yes	6	8	1	2
R:R:H295	R:R:M223	3.94	2	Yes	Yes	6	6	1	1
R:R:F349	R:R:Y227	4.13	2	Yes	Yes	8	8	2	2
R:R:M373	R:R:Y227	3.59	2	Yes	Yes	7	8	1	2
R:R:H270	R:R:R274	11.28	2	Yes	Yes	8	7	2	2
R:R:H270	R:R:L291	2.57	2	Yes	No	8	5	2	1
R:R:H270	R:R:I294	11.93	2	Yes	No	8	7	2	2
R:R:R274	R:R:Y278	4.12	2	Yes	Yes	7	6	2	2
R:R:L291	R:R:R274	2.43	2	No	Yes	5	7	1	2
R:R:S285	R:R:Y278	10.17	2	Yes	Yes	5	6	2	2
R:R:D287	R:R:Y278	3.45	2	No	Yes	3	6	1	2
R:R:C282	R:R:I284	3.27	0	No	No	9	6	2	1
R:R:D287	R:R:S285	4.42	2	No	Yes	3	5	1	2
R:R:H289	R:R:Y292	8.71	0	No	No	4	6	2	1
R:R:F349	R:R:M373	7.46	2	Yes	Yes	8	7	2	1
R:R:E363	R:R:W354	3.27	8	No	No	4	5	2	1
R:R:W354	R:R:Y365	10.61	8	No	Yes	5	6	1	2
R:R:E363	R:R:Y365	5.61	8	No	Yes	4	6	2	2
R:R:M369	R:R:Y365	10.78	0	No	Yes	8	6	1	2
R:R:D366	R:R:H370	10.08	2	No	Yes	6	7	2	1
R:R:H370	R:R:H374	9.55	2	Yes	Yes	7	9	1	2
R:R:H374	R:R:M373	6.57	2	Yes	Yes	9	7	2	1
E:E:T73	E:E:W84	3.64	1	Yes	Yes	9	9	2	1
E:E:W74	E:E:W84	10.31	0	No	Yes	1	9	2	1
E:E:A77	E:E:W84	3.89	0	No	Yes	9	9	2	1
E:E:P85	E:E:W84	13.51	1	No	Yes	9	9	1	1
E:E:V89	E:E:W84	6.13	0	No	Yes	9	9	2	1
L:L:A13	R:R:A199	1.79	0	No	No	0	4	0	1
L:L:G14	R:R:I284	1.76	0	No	No	0	6	0	1
L:L:P29	R:R:D94	1.61	0	No	Yes	0	5	0	1
L:L:V22	R:R:T131	1.59	0	No	No	0	1	0	1
R:R:T131	R:R:V135	1.59	0	No	Yes	1	1	1	1
L:L:L15	R:R:A138	1.58	0	No	No	0	5	0	1
L:L:L16	R:R:A138	1.58	2	No	No	0	5	0	1
L:L:T9	R:R:T191	1.57	0	No	No	0	7	0	1
R:R:N128	R:R:V129	1.48	0	No	No	3	2	1	2
R:R:F142	R:R:N200	1.21	2	Yes	No	6	3	1	2
L:L:D3	R:R:R355	1.19	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6E3Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.38
Number of Linked Nodes	463
Number of Links	595
Number of Hubs	105
Number of Links mediated by Hubs	369
Number of Communities	13
Number of Nodes involved in Communities	141
Number of Links involved in Communities	214

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	1794038
Length Of Smallest Path	3
Average Path Length	26.8737
Length of Longest Path	40
Minimum Path Strength	1.3
Average Path Strength	5.81786
Maximum Path Strength	22.84
Minimum Path Correlation	0.7
Average Path Correlation	0.968582
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	33.7568
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	59.9486
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cell population proliferation • endothelial cell proliferation • cellular process • epithelial cell proliferation • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • regulation of cellular process • interleukin-1 production • positive regulation of biological process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of interleukin-1 alpha production • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of interleukin-1 production • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of biosynthetic process • regulation of biological process • regulation of interleukin-1 production • regulation of macromolecule metabolic process • gene expression • regulation of interleukin-1 alpha production • macromolecule biosynthetic process • regulation of gene expression • interleukin-1 alpha production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • endothelial cell migration • cell migration • cell motility • signaling • cell-cell signaling • cell communication • cellular response to stimulus • response to stimulus • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • negative regulation of cellular process • regulation of immune system process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • negative regulation of tissue remodeling • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • protein phosphorylation • phosphorylation • primary metabolic process • macromolecule modification • phosphate-containing compound metabolic process • protein metabolic process • protein modification process • phosphorus metabolic process • calcitonin gene-related peptide receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • cell adhesion • cell-cell adhesion • leukocyte cell-cell adhesion • mononuclear cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • positive regulation of hemopoiesis • regulation of macrophage differentiation • positive regulation of immune system process • positive regulation of cell development • macrophage differentiation • positive regulation of myeloid leukocyte differentiation • positive regulation of macrophage differentiation • positive regulation of myeloid cell differentiation • positive regulation of leukocyte differentiation • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • regulation of systemic arterial blood pressure • nervous system process • nervous system process involved in regulation of systemic arterial blood pressure • vasculature development • system development • circulatory system development • regulation of localization • regulation of calcium ion transport • cellular localization • regulation of calcium ion transport into cytosol • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • negative regulation of transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • negative regulation of transmembrane transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • monoatomic ion transport • negative regulation of cation transmembrane transport • negative regulation of calcium ion transport into cytosol • monoatomic cation transport • regulation of metal ion transport • calcium ion transmembrane import into cytosol • regulation of transport • regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • negative regulation of calcium ion transport • transmembrane transport • regulation of transmembrane transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • negative regulation of cytosolic calcium ion concentration • calcium ion transmembrane transport • calcium ion transport into cytosol • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • G protein-coupled receptor internalization • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • negative regulation of blood pressure • cellular anatomical structure • intracellular anatomical structure • cytoplasm • extracellular region • extracellular space • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • calcitonin family binding • amide binding • adrenomedullin binding • peptide hormone binding • hormone binding • adrenomedullin receptor activity • calcitonin gene-related peptide receptor activity • heart development • blood vessel morphogenesis • tube development • angiogenesis • tube morphogenesis • blood vessel development • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell surface receptor signaling pathway • adrenomedullin receptor signaling pathway • response to disaccharide • cellular response to sucrose stimulus • cellular response to carbohydrate stimulus • response to carbohydrate • response to sucrose • cellular response to disaccharide stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • endosome • intracellular vesicle • cytoplasmic vesicle • CGRP receptor complex • endoplasmic reticulum • calcitonin gene-related peptide binding • coreceptor activity • amylin receptor activity • intracellular protein transport • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • cell surface
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • RAMP1-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • RAMP1-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16602
Sequence	>6E3Y_nogp_Chain_R Q L G V T R N K I M T A Q Y E C Y Q K I M Q Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D N W F R H P A S N R T W T N Y T Q C N V N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F K S L S C Q R I T L H K N L F F S F V C N S V V T I I H L T A V A N N Q A L V A T N P V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V A V F A E K Q H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y N D N C W I S S D T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K V T N L Y M K A V R A T L I L V P L L G I E F V L I P W R E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E V Q A I L R R N W N Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>6E3Y_nogp_Chain_E E A N Y G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S G R A V R D P P G S I L Y P F I V V P I T V T L L V T A L V V W Q S K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	doi.org/10.1126/science.abf7258
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	doi.org/10.1126/science.abf7258

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6E3Y_nogp.zip

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