psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q33	R:R:Q93	3.84	No	No	0	4	4
2	R:R:G35	R:R:L34	1.71	No	No	0	2	2
3	R:R:L34	R:R:R38	2.43	No	No	0	2	5
4	R:R:T37	R:R:Y91	3.75	No	Yes	0	4	5
5	R:R:I41	R:R:R38	10.02	No	No	0	6	5
6	E:E:R67	R:R:R38	18.13	Yes	No	0	5	5
7	E:E:I63	R:R:N39	4.25	Yes	No	2	5	5
8	E:E:R67	R:R:N39	3.62	Yes	No	2	5	5
9	R:R:D90	R:R:K40	6.91	No	No	0	3	5
10	R:R:K40	R:R:Y91	7.17	No	Yes	0	5	5
11	R:R:I41	R:R:W72	2.35	No	Yes	3	6	5
12	R:R:I41	R:R:Y91	10.88	No	Yes	3	6	5
13	R:R:M42	R:R:Q45	2.72	Yes	Yes	2	3	5
14	E:E:Y66	R:R:M42	2.39	Yes	Yes	2	9	3
15	E:E:R67	R:R:M42	6.2	Yes	Yes	2	5	3
16	E:E:A70	R:R:M42	3.22	No	Yes	0	7	3
17	R:R:E47	R:R:T43	2.82	Yes	No	0	6	5
18	E:E:W59	R:R:T43	8.49	Yes	No	0	7	5
19	R:R:A44	R:R:W69	3.89	No	Yes	0	6	7
20	R:R:Q45	R:R:W69	17.52	Yes	Yes	2	5	7
21	E:E:Y66	R:R:Q45	3.38	Yes	Yes	2	9	5
22	E:E:F93	R:R:Q45	7.03	Yes	Yes	2	9	5
23	R:R:E47	R:R:Y46	4.49	Yes	Yes	2	6	2
24	R:R:Q50	R:R:Y46	24.8	No	Yes	2	4	2
25	E:E:C57	R:R:Y46	2.69	No	Yes	2	9	2
26	E:E:W59	R:R:Y46	20.26	Yes	Yes	2	7	2
27	E:E:Y66	R:R:Y46	5.96	Yes	Yes	2	9	2
28	E:E:H97	R:R:Y46	4.36	Yes	Yes	2	9	2
29	E:E:F101	R:R:Y46	10.32	Yes	Yes	2	9	2
30	E:E:R109	R:R:Y46	7.2	No	Yes	2	5	2
31	R:R:E47	R:R:Q50	3.82	Yes	No	2	6	4
32	E:E:S107	R:R:E47	4.31	No	Yes	0	5	6
33	E:E:R109	R:R:E47	16.28	No	Yes	2	5	6
34	R:R:C48	R:R:Y49	4.03	Yes	Yes	2	9	3
35	R:R:C48	R:R:I52	3.27	Yes	No	0	9	5
36	R:R:C48	R:R:W69	5.22	Yes	Yes	2	9	7
37	R:R:C48	R:R:C74	7.28	Yes	No	2	9	9
38	R:R:W69	R:R:Y49	3.86	Yes	Yes	2	7	3
39	E:E:D90	R:R:Y49	9.2	No	Yes	0	8	3
40	E:E:F93	R:R:Y49	5.16	Yes	Yes	2	9	3
41	E:E:H97	R:R:Y49	5.44	Yes	Yes	2	9	3
42	E:E:H97	R:R:Q50	8.65	Yes	No	2	9	4
43	R:R:K51	R:R:R67	6.19	No	No	0	3	4
44	R:R:K51	R:R:N76	9.79	No	No	0	3	6
45	R:R:I52	R:R:R67	5.01	No	No	0	5	4
46	E:E:L94	R:R:M53	2.83	No	Yes	0	6	2
47	E:E:G98	R:R:M53	1.75	No	Yes	0	5	2
48	E:E:R102	R:R:M53	3.72	No	Yes	0	5	2
49	E:E:I106	R:R:Q54	4.12	No	No	0	4	2
50	R:R:N66	R:R:Y64	2.33	No	No	0	5	3
51	R:R:D77	R:R:Y64	11.49	No	No	0	4	3
52	R:R:A79	R:R:Y64	2.67	No	No	0	1	3
53	R:R:C65	R:R:V78	1.71	No	Yes	3	9	7
54	R:R:C105	R:R:C65	7.28	No	No	3	9	9
55	R:R:C65	R:R:W111	19.59	No	Yes	3	9	9
56	R:R:D77	R:R:R67	3.57	No	No	0	4	4
57	R:R:T68	R:R:W111	2.43	No	Yes	0	5	9
58	R:R:G71	R:R:W69	8.44	No	Yes	0	4	7
59	R:R:C74	R:R:W69	2.61	No	Yes	2	9	7
60	R:R:D70	R:R:G71	3.35	Yes	No	0	9	4
61	R:R:D70	R:R:L73	4.07	Yes	Yes	3	9	5
62	R:R:D70	R:R:W75	2.23	Yes	Yes	3	9	9
63	R:R:D70	R:R:T122	7.23	Yes	No	3	9	7
64	R:R:D70	R:R:Y124	10.34	Yes	Yes	3	9	4
65	E:E:P85	R:R:G71	4.06	No	No	0	9	4
66	R:R:W72	R:R:Y91	1.93	Yes	Yes	3	5	5
67	R:R:F92	R:R:W72	4.01	No	Yes	3	6	5
68	R:R:F95	R:R:W72	5.01	Yes	Yes	3	5	5
69	R:R:W72	R:R:Y124	15.43	Yes	Yes	3	5	4
70	R:R:L73	R:R:W75	3.42	Yes	Yes	3	5	9
71	R:R:L73	R:R:Q86	6.65	Yes	No	3	5	5
72	R:R:L73	R:R:P89	11.49	Yes	No	0	5	8
73	R:R:L73	R:R:V101	4.47	Yes	Yes	3	5	7
74	R:R:L73	R:R:Y124	7.03	Yes	Yes	3	5	4
75	R:R:S84	R:R:W75	4.94	No	Yes	0	7	9
76	R:R:Q86	R:R:W75	14.24	No	Yes	3	5	9
77	R:R:V101	R:R:W75	2.45	Yes	Yes	3	7	9
78	R:R:K103	R:R:W75	9.28	Yes	Yes	3	8	9
79	R:R:T82	R:R:V78	9.52	No	Yes	0	5	7
80	R:R:C105	R:R:V78	3.42	No	Yes	3	9	7
81	R:R:V78	R:R:W111	3.68	Yes	Yes	3	7	9
82	R:R:E83	R:R:M85	4.06	No	No	0	3	4
83	R:R:E83	R:R:T102	12.7	No	No	0	3	5
84	R:R:E83	R:R:I104	4.1	No	No	0	3	4
85	R:R:K100	R:R:M85	7.2	No	No	0	3	4
86	R:R:C88	R:R:P89	3.77	Yes	No	0	9	8
87	R:R:C88	R:R:F95	5.59	Yes	Yes	3	9	5
88	R:R:C88	R:R:V101	1.71	Yes	Yes	3	9	7
89	R:R:C127	R:R:C88	7.28	No	Yes	3	9	9
90	R:R:P89	R:R:Y91	11.13	No	Yes	0	8	5
91	R:R:D90	R:R:P97	3.22	No	No	0	3	3
92	R:R:F92	R:R:Y91	4.13	No	Yes	3	6	5
93	R:R:F92	R:R:F95	8.57	No	Yes	3	6	5
94	R:R:D94	R:R:F95	9.55	No	Yes	3	5	5
95	R:R:D94	R:R:N128	12.12	No	No	3	5	3
96	R:R:C127	R:R:F95	5.59	No	Yes	3	9	5
97	R:R:F95	R:R:N128	7.25	Yes	No	3	5	3
98	R:R:D96	R:R:P97	4.83	No	No	0	5	3
99	R:R:D96	R:R:S98	8.83	No	No	0	5	3
100	R:R:D96	R:R:E99	2.6	No	No	0	5	5
101	R:R:E99	R:R:Q126	6.37	No	No	0	5	5
102	R:R:C127	R:R:E99	6.08	No	No	0	9	5
103	R:R:V101	R:R:Y124	2.52	Yes	Yes	3	7	4
104	R:R:N123	R:R:T102	2.92	Yes	No	0	8	5
105	R:R:K103	R:R:W111	18.57	Yes	Yes	3	8	9
106	R:R:K103	R:R:T120	4.5	Yes	No	3	8	5
107	R:R:K103	R:R:T122	7.51	Yes	No	3	8	7
108	R:R:F112	R:R:I104	2.51	Yes	No	0	5	4
109	R:R:C105	R:R:W111	3.92	No	Yes	3	9	9
110	R:R:D106	R:R:N110	5.39	No	No	0	5	5
111	R:R:T120	R:R:W111	2.43	No	Yes	3	5	9
112	R:R:F112	R:R:P115	2.89	Yes	No	0	5	3
113	R:R:F112	R:R:W121	3.01	Yes	No	0	5	8
114	R:R:N118	R:R:R113	10.85	No	No	0	6	1
115	R:R:H114	R:R:P115	6.1	Yes	No	0	4	3
116	R:R:A116	R:R:H114	2.93	No	Yes	0	3	4
117	R:R:H114	R:R:S117	13.95	Yes	No	0	4	4
118	R:R:H114	R:R:W121	15.87	Yes	No	0	4	8
119	R:R:R119	R:R:S117	9.22	No	No	0	4	4
120	E:E:F83	R:R:R119	11.76	No	No	0	5	4
121	R:R:N123	R:R:W121	4.52	Yes	No	0	8	8
122	R:R:T122	R:R:Y124	8.74	No	Yes	3	7	4
123	R:R:N123	R:R:T125	5.85	Yes	No	6	8	6
124	R:R:N123	R:R:Q126	9.24	Yes	No	6	8	5
125	R:R:Q126	R:R:T125	5.67	No	No	6	5	6
126	R:R:E133	R:R:N130	15.77	Yes	No	0	1	2
127	R:R:E133	R:R:K136	2.7	Yes	No	0	1	2
128	R:R:T137	R:R:Y367	6.24	No	No	0	4	6
129	R:R:L139	R:R:Y143	3.52	No	No	0	3	4
130	R:R:D366	R:R:L141	5.43	No	No	1	6	6
131	R:R:L141	R:R:Y367	8.21	No	No	0	6	6
132	R:R:H370	R:R:L141	10.29	Yes	No	1	7	6
133	R:R:F142	R:R:Y143	5.16	Yes	No	0	6	4
134	R:R:F142	R:R:I146	7.54	Yes	No	0	6	6
135	R:R:F142	R:R:L195	7.31	Yes	No	0	6	7
136	R:R:F142	R:R:T196	2.59	Yes	No	0	6	3
137	R:R:F375	R:R:L144	2.44	Yes	No	0	7	6
138	R:R:H149	R:R:T145	2.74	Yes	No	1	7	7
139	R:R:L195	R:R:T145	4.42	No	No	0	7	7
140	R:R:H374	R:R:T145	21.91	Yes	No	1	9	7
141	R:R:I146	R:R:I192	4.42	No	No	0	6	6
142	R:R:G148	R:R:I147	1.76	No	No	7	9	5
143	R:R:F375	R:R:I147	5.02	Yes	No	7	7	5
144	R:R:F375	R:R:G148	9.03	Yes	No	7	7	9
145	R:R:H149	R:R:S188	9.76	Yes	No	0	7	8
146	R:R:H149	R:R:T191	8.21	Yes	No	1	7	7
147	R:R:H149	R:R:I192	2.65	Yes	No	0	7	6
148	R:R:H149	R:R:H374	14.33	Yes	Yes	1	7	9
149	R:R:F375	R:R:L151	3.65	Yes	No	0	7	5
150	R:R:L151	R:R:L378	4.15	No	No	0	5	6
151	R:R:G377	R:R:S152	3.71	No	No	0	9	9
152	R:R:I153	R:R:S188	3.1	No	No	0	6	8
153	R:R:L378	R:R:S155	9.01	No	No	0	6	6
154	R:R:F181	R:R:L156	2.44	Yes	Yes	1	8	9
155	R:R:L156	R:R:V185	4.47	Yes	No	0	9	7
156	R:R:G377	R:R:L156	1.71	No	Yes	0	9	9
157	R:R:L156	R:R:S381	9.01	Yes	Yes	1	9	8
158	R:R:L157	R:R:V185	2.98	No	No	0	3	7
159	R:R:F386	R:R:I158	3.77	No	No	0	8	5
160	R:R:S159	R:R:S381	6.52	No	Yes	0	8	8
161	R:R:C385	R:R:S159	6.89	Yes	No	0	9	8
162	R:R:F386	R:R:S159	7.93	No	No	0	8	8
163	R:R:F181	R:R:L160	2.44	Yes	No	0	8	5
164	R:R:F166	R:R:I162	6.28	No	No	0	7	8
165	R:R:C385	R:R:I162	3.27	Yes	No	0	9	8
166	R:R:F163	R:R:I174	5.02	Yes	Yes	1	7	9
167	R:R:F163	R:R:K178	2.48	Yes	Yes	1	7	6
168	R:R:F163	R:R:F181	5.36	Yes	Yes	1	7	8
169	R:R:C385	R:R:F163	6.98	Yes	Yes	1	9	7
170	R:R:F163	R:R:V391	2.62	Yes	Yes	1	7	9
171	R:R:F164	R:R:K178	6.2	No	Yes	0	4	6
172	R:R:F166	R:R:I394	11.3	No	No	0	7	8
173	R:R:E390	R:R:L169	7.95	No	No	0	9	9
174	R:R:L169	R:R:V391	2.98	No	Yes	0	9	9
175	R:R:C171	R:R:I174	3.27	No	Yes	0	8	9
176	R:R:C171	R:R:E248	3.04	No	No	0	8	6
177	R:R:Q172	R:R:Y236	10.15	Yes	Yes	4	7	8
178	R:R:E248	R:R:Q172	5.1	No	Yes	0	6	7
179	R:R:Q172	R:R:Q250	6.4	Yes	Yes	4	7	6
180	R:R:L252	R:R:Q172	6.65	No	Yes	0	6	7
181	R:R:H177	R:R:R173	10.16	Yes	No	0	9	9
182	R:R:A334	R:R:R173	5.53	No	No	0	8	9
183	R:R:H177	R:R:I174	5.3	Yes	Yes	0	9	9
184	R:R:I174	R:R:K178	7.27	Yes	Yes	1	9	6
185	R:R:L176	R:R:W229	4.56	No	Yes	0	9	9
186	R:R:E233	R:R:L176	7.95	No	No	0	9	9
187	R:R:L176	R:R:Y236	4.69	No	Yes	0	9	8
188	R:R:E233	R:R:H177	7.39	No	Yes	0	9	9
189	R:R:F384	R:R:H177	14.71	Yes	Yes	0	8	9
190	R:R:N179	R:R:W229	12.43	No	Yes	1	8	9
191	R:R:N179	R:R:Y256	9.3	No	No	1	8	5
192	R:R:N179	R:R:W260	2.26	No	Yes	1	8	9
193	R:R:F184	R:R:L180	6.09	Yes	Yes	0	8	9
194	R:R:L180	R:R:W229	2.28	Yes	Yes	1	9	9
195	R:R:L180	R:R:M230	2.83	Yes	Yes	1	9	9
196	R:R:E233	R:R:L180	2.65	No	Yes	0	9	9
197	R:R:F384	R:R:L180	2.44	Yes	Yes	1	8	9
198	R:R:F181	R:R:V380	3.93	Yes	Yes	1	8	9
199	R:R:F181	R:R:S381	3.96	Yes	Yes	1	8	8
200	R:R:F181	R:R:F384	5.36	Yes	Yes	1	8	8
201	R:R:F182	R:R:W260	4.01	No	Yes	0	4	9
202	R:R:C225	R:R:S183	1.72	No	No	0	8	8
203	R:R:N226	R:R:S183	5.96	Yes	No	0	8	8
204	R:R:F184	R:R:N226	16.92	Yes	Yes	0	8	8
205	R:R:F184	R:R:Q376	3.51	Yes	No	0	8	9
206	R:R:F184	R:R:V380	9.18	Yes	Yes	0	8	9
207	R:R:C186	R:R:L222	4.76	No	Yes	0	7	5
208	R:R:N187	R:R:T191	4.39	Yes	No	1	8	7
209	R:R:H219	R:R:N187	5.1	No	Yes	1	6	8
210	R:R:L222	R:R:N187	4.12	Yes	Yes	1	5	8
211	R:R:N187	R:R:N226	10.9	Yes	Yes	0	8	8
212	R:R:I218	R:R:V190	6.14	Yes	No	1	5	6
213	R:R:L222	R:R:V190	2.98	Yes	No	1	5	6
214	R:R:H219	R:R:T191	4.11	No	No	1	6	7
215	R:R:H194	R:R:V198	5.54	No	No	0	7	6
216	R:R:H194	R:R:S215	11.16	No	No	0	7	6
217	R:R:H194	R:R:Q216	7.42	No	Yes	0	7	6
218	R:R:A197	R:R:V198	1.7	No	No	0	5	6
219	R:R:C212	R:R:V198	6.83	No	No	0	9	6
220	R:R:N200	R:R:N201	14.98	No	Yes	0	3	4
221	R:R:L204	R:R:N201	10.98	No	Yes	0	4	4
222	R:R:N281	R:R:V205	5.91	No	No	5	4	4
223	R:R:C282	R:R:V205	3.42	Yes	No	5	9	4
224	R:R:P209	R:R:T207	5.25	Yes	No	0	5	3
225	R:R:K213	R:R:N208	4.2	No	No	0	8	6
226	R:R:N208	R:R:N281	13.62	No	No	0	6	4
227	R:R:P209	R:R:S211	1.78	Yes	No	0	5	4
228	R:R:C212	R:R:P209	7.53	No	Yes	5	9	5
229	R:R:C282	R:R:P209	1.88	Yes	Yes	5	9	5
230	R:R:C212	R:R:C282	7.28	No	Yes	5	9	9
231	R:R:K213	R:R:N279	11.19	No	No	1	8	6
232	R:R:K213	R:R:W283	29.01	No	Yes	1	8	8
233	R:R:H219	R:R:Q216	3.71	No	Yes	0	6	6
234	R:R:L220	R:R:Q216	9.32	Yes	Yes	0	7	6
235	R:R:Q216	R:R:W283	4.38	Yes	Yes	0	6	8
236	R:R:F217	R:R:I218	3.77	No	Yes	0	6	5
237	R:R:A267	R:R:F217	4.16	No	No	0	6	6
238	R:R:I218	R:R:L222	2.85	Yes	Yes	1	5	5
239	R:R:H270	R:R:L220	5.14	Yes	Yes	1	8	7
240	R:R:L220	R:R:L291	4.15	Yes	Yes	1	7	5
241	R:R:I294	R:R:L220	8.56	No	Yes	1	7	7
242	R:R:L222	R:R:Y221	3.52	Yes	Yes	1	5	8
243	R:R:C225	R:R:Y221	6.72	No	Yes	1	8	8
244	R:R:W260	R:R:Y221	3.86	Yes	Yes	1	9	8
245	R:R:P263	R:R:Y221	2.78	Yes	Yes	1	9	8
246	R:R:L264	R:R:Y221	4.69	No	Yes	0	3	8
247	R:R:A267	R:R:Y221	2.67	No	Yes	0	6	8
248	R:R:H295	R:R:M223	5.25	Yes	No	1	6	6
249	R:R:I298	R:R:M223	4.37	Yes	No	1	7	6
250	R:R:F349	R:R:M223	2.49	Yes	No	1	8	6
251	R:R:G224	R:R:P263	2.03	No	Yes	0	5	9
252	R:R:G224	R:R:I298	3.53	No	Yes	0	5	7
253	R:R:C225	R:R:P263	5.65	No	Yes	1	8	9
254	R:R:N226	R:R:Y227	2.33	Yes	Yes	0	8	8
255	R:R:I298	R:R:Y227	12.09	Yes	Yes	1	7	8
256	R:R:L302	R:R:Y227	8.21	No	Yes	0	7	8
257	R:R:L345	R:R:Y227	2.34	Yes	Yes	1	9	8
258	R:R:F349	R:R:Y227	4.13	Yes	Yes	1	8	8
259	R:R:Q376	R:R:Y227	5.64	No	Yes	1	9	8
260	R:R:F228	R:R:F262	7.5	Yes	Yes	1	5	4
261	R:R:F228	R:R:P263	10.11	Yes	Yes	1	5	9
262	R:R:F228	R:R:P297	4.33	Yes	Yes	1	5	8
263	R:R:A301	R:R:F228	2.77	No	Yes	0	7	5
264	E:E:T130	R:R:F228	3.89	No	Yes	1	9	5
265	R:R:C232	R:R:W229	5.22	No	Yes	0	7	9
266	R:R:W229	R:R:Y256	1.93	Yes	No	1	9	5
267	R:R:G259	R:R:W229	8.44	No	Yes	0	9	9
268	R:R:W229	R:R:W260	10.31	Yes	Yes	1	9	9
269	R:R:L341	R:R:M230	4.24	Yes	Yes	1	9	9
270	R:R:L345	R:R:M230	2.83	Yes	Yes	1	9	9
271	R:R:F384	R:R:M230	3.73	Yes	Yes	1	8	9
272	R:R:I235	R:R:L231	5.71	Yes	Yes	0	6	8
273	R:R:L231	R:R:L258	2.77	Yes	Yes	0	8	6
274	R:R:L231	R:R:N305	10.98	Yes	No	0	8	9
275	E:E:T134	R:R:L231	5.9	No	Yes	0	8	8
276	R:R:C232	R:R:Y255	9.41	No	Yes	0	7	8
277	R:R:C232	R:R:L258	4.76	No	Yes	0	7	6
278	R:R:G234	R:R:L237	1.71	No	Yes	0	8	9
279	R:R:G234	R:R:N305	1.7	No	No	0	8	9
280	R:R:G234	R:R:L309	1.71	No	No	0	8	9
281	R:R:I235	R:R:Y255	7.25	Yes	Yes	0	6	8
282	R:R:F308	R:R:I235	5.02	No	Yes	0	8	6
283	E:E:V138	R:R:I235	3.07	No	Yes	0	9	6
284	R:R:L240	R:R:Y236	11.72	No	Yes	4	8	8
285	R:R:Q250	R:R:Y236	13.53	Yes	Yes	4	6	8
286	R:R:Y236	R:R:Y255	2.98	Yes	Yes	4	8	8
287	R:R:I241	R:R:L237	2.85	No	Yes	0	8	9
288	R:R:I312	R:R:L237	4.28	No	Yes	0	9	9
289	R:R:L237	R:R:V335	4.47	Yes	No	0	9	8
290	R:R:H238	R:R:V242	6.92	Yes	No	0	8	6
291	R:R:F308	R:R:H238	15.84	No	Yes	0	8	8
292	R:R:H238	R:R:N311	5.1	Yes	No	0	8	7
293	R:R:H238	R:R:I312	9.28	Yes	No	0	8	9
294	R:R:T239	R:R:V243	4.76	Yes	No	0	7	5
295	R:R:Q250	R:R:T239	7.09	Yes	Yes	4	6	7
296	R:R:T239	R:R:Y255	2.5	Yes	Yes	4	7	8
297	E:E:S141	R:R:T239	6.4	No	Yes	4	9	7
298	R:R:L240	R:R:Q250	6.65	No	Yes	4	8	6
299	R:R:I241	R:R:V242	3.07	No	No	0	8	6
300	R:R:I241	R:R:L316	2.85	No	No	0	8	8
301	R:R:V242	R:R:V315	4.81	No	No	0	6	8
302	E:E:K142	R:R:V243	6.07	No	No	0	8	5
303	R:R:A244	R:R:A247	1.79	No	No	0	6	6
304	R:R:F246	R:R:V245	3.93	No	No	0	6	7
305	R:R:F246	R:R:Y331	16.5	No	No	0	6	7
306	R:R:A247	R:R:K249	6.42	No	No	0	6	5
307	R:R:M253	R:R:Y256	2.39	No	No	0	3	5
308	E:E:Q140	R:R:W254	21.9	No	No	0	7	2
309	E:E:S141	R:R:Y255	5.09	No	Yes	4	9	8
310	R:R:G259	R:R:L258	1.71	No	Yes	0	9	6
311	R:R:F262	R:R:L258	3.65	Yes	Yes	0	4	6
312	R:R:G259	R:R:P263	2.03	No	Yes	0	9	9
313	R:R:G261	R:R:P263	2.03	No	Yes	0	7	9
314	R:R:F262	R:R:P263	4.33	Yes	Yes	1	4	9
315	E:E:T130	R:R:F262	9.08	No	Yes	1	9	4
316	E:E:V133	R:R:F262	6.55	No	Yes	0	7	4
317	R:R:I265	R:R:P266	5.08	No	No	0	4	6
318	R:R:P266	R:R:P297	3.9	No	Yes	0	6	8
319	R:R:I269	R:R:I293	4.42	No	No	0	5	8
320	E:E:F122	R:R:I269	2.51	No	No	0	8	5
321	E:E:P126	R:R:I269	3.39	No	No	0	9	5
322	R:R:H270	R:R:R274	10.16	Yes	Yes	1	8	7
323	R:R:H270	R:R:L290	2.57	Yes	Yes	1	8	3
324	R:R:H270	R:R:L291	9	Yes	Yes	1	8	5
325	R:R:H270	R:R:I293	7.95	Yes	No	0	8	8
326	R:R:H270	R:R:I294	6.63	Yes	No	1	8	7
327	E:E:F122	R:R:A273	5.55	No	No	0	8	5
328	R:R:R274	R:R:W283	22.99	Yes	Yes	1	7	8
329	R:R:R274	R:R:S285	3.95	Yes	Yes	1	7	5
330	R:R:R274	R:R:T288	11.64	Yes	Yes	1	7	5
331	R:R:L290	R:R:R274	4.86	Yes	Yes	1	3	7
332	R:R:L291	R:R:R274	6.07	Yes	Yes	1	5	7
333	R:R:N279	R:R:S275	2.98	No	No	0	6	3
334	R:R:L276	R:R:Y277	10.55	No	Yes	0	3	3
335	E:E:P114	R:R:Y277	8.34	No	Yes	0	9	3
336	E:E:I118	R:R:Y277	6.04	No	Yes	0	6	3
337	E:E:F122	R:R:Y277	6.19	No	Yes	0	8	3
338	R:R:D280	R:R:Y278	5.75	No	Yes	1	4	6
339	R:R:S285	R:R:Y278	6.36	Yes	Yes	1	5	6
340	R:R:D287	R:R:Y278	10.34	No	Yes	1	3	6
341	R:R:T288	R:R:Y278	18.73	Yes	Yes	1	5	6
342	R:R:L290	R:R:Y278	2.34	Yes	Yes	1	3	6
343	E:E:V111	R:R:Y278	2.52	No	Yes	0	4	6
344	R:R:N279	R:R:W283	9.04	No	Yes	1	6	8
345	R:R:D280	R:R:I284	4.2	No	No	0	4	6
346	R:R:D280	R:R:S285	11.78	No	Yes	1	4	5
347	R:R:C282	R:R:N281	3.15	Yes	No	5	9	4
348	R:R:D287	R:R:S285	7.36	No	Yes	1	3	5
349	R:R:S285	R:R:T288	3.2	Yes	Yes	1	5	5
350	R:R:D287	R:R:T288	2.89	No	Yes	1	3	5
351	R:R:L290	R:R:T288	7.37	Yes	Yes	1	3	5
352	R:R:L291	R:R:T288	7.37	Yes	Yes	1	5	5
353	E:E:D113	R:R:H289	5.04	No	No	0	9	4
354	E:E:L119	R:R:H289	5.14	Yes	No	0	8	4
355	R:R:H295	R:R:Y292	3.27	Yes	No	0	6	6
356	R:R:H295	R:R:I294	2.65	Yes	No	1	6	7
357	R:R:F349	R:R:H295	13.58	Yes	Yes	1	8	6
358	R:R:G296	R:R:P297	4.06	No	Yes	0	4	8
359	E:E:I127	R:R:G296	3.53	No	No	0	8	4
360	E:E:P126	R:R:P297	3.9	No	Yes	0	9	8
361	E:E:T130	R:R:P297	6.99	No	Yes	1	9	8
362	R:R:F349	R:R:I298	3.77	Yes	Yes	1	8	7
363	R:R:G346	R:R:L302	1.71	No	No	0	9	7
364	R:R:F308	R:R:V304	2.62	No	No	0	8	6
365	R:R:L306	R:R:L310	2.77	No	No	0	5	5
366	R:R:L309	R:R:L339	4.15	No	Yes	0	9	7
367	R:R:N311	R:R:R314	6.03	No	No	0	7	7
368	R:R:R314	R:R:V315	3.92	No	No	0	7	8
369	R:R:K319	R:R:V315	4.55	No	No	0	9	8
370	R:R:L316	R:R:Y331	4.69	No	No	0	8	7
371	R:R:K319	R:R:T318	4.5	No	No	0	9	7
372	R:R:N329	R:R:Y331	13.96	No	No	0	5	7
373	R:R:K333	R:R:M332	5.76	No	No	8	8	6
374	R:R:M332	R:R:R336	11.17	No	No	8	6	8
375	R:R:K333	R:R:R336	2.48	No	No	8	8	8
376	R:R:L339	R:R:V335	2.98	Yes	No	0	7	8
377	R:R:A337	R:R:F384	2.77	No	Yes	0	9	8
378	R:R:F384	R:R:T338	6.49	Yes	No	0	8	9
379	R:R:L341	R:R:L345	8.3	Yes	Yes	1	9	9
380	R:R:L341	R:R:L379	2.77	Yes	No	0	9	5
381	R:R:L341	R:R:V380	7.45	Yes	Yes	1	9	9
382	R:R:I383	R:R:L341	7.14	No	Yes	0	7	9
383	R:R:F384	R:R:L341	4.87	Yes	Yes	1	8	9
384	R:R:P343	R:R:V342	3.53	No	No	0	9	8
385	R:R:L344	R:R:L379	6.92	No	No	0	9	5
386	R:R:L345	R:R:Q376	5.32	Yes	No	1	9	9
387	R:R:L345	R:R:V380	2.98	Yes	Yes	1	9	9
388	R:R:I347	R:R:V350	3.07	No	No	0	7	6
389	R:R:I347	R:R:L351	4.28	No	No	0	7	5
390	R:R:I347	R:R:L372	2.85	No	No	0	7	6
391	R:R:E348	R:R:F349	13.99	Yes	Yes	0	8	8
392	R:R:E348	R:R:I352	2.73	Yes	No	0	8	7
393	R:R:E348	R:R:L372	2.65	Yes	No	0	8	6
394	R:R:E348	R:R:M373	8.12	Yes	Yes	0	8	7
395	R:R:L351	R:R:M369	4.24	No	No	0	5	8
396	R:R:I352	R:R:P353	3.39	No	No	0	7	6
397	R:R:E363	R:R:W354	2.18	No	No	9	4	5
398	R:R:W354	R:R:Y365	14.47	No	No	9	5	6
399	R:R:E363	R:R:Y365	5.61	No	No	9	4	6
400	R:R:M369	R:R:Y365	3.59	No	No	0	8	6
401	R:R:D366	R:R:H370	8.82	No	Yes	1	6	7
402	R:R:M369	R:R:M373	7.22	No	Yes	0	8	7
403	R:R:H370	R:R:M373	3.94	Yes	Yes	1	7	7
404	R:R:H370	R:R:H374	9.55	Yes	Yes	1	7	9
405	R:R:F375	R:R:I371	7.54	Yes	No	0	7	6
406	R:R:H374	R:R:M373	6.57	Yes	Yes	1	9	7
407	R:R:F384	R:R:V380	3.93	Yes	Yes	1	8	9
408	R:R:I383	R:R:T382	3.04	No	No	0	7	5
409	R:R:F387	R:R:T382	2.59	No	No	0	5	5
410	R:R:C385	R:R:V391	1.71	Yes	Yes	1	9	9
411	R:R:F387	R:R:Q392	2.34	No	No	0	5	7
412	R:R:G389	R:R:N388	1.7	No	No	0	6	9
413	R:R:N388	R:R:V391	8.87	No	Yes	0	9	9
414	R:R:Q392	R:R:R396	2.34	No	No	0	7	5
415	R:R:I394	R:R:L395	2.85	No	No	0	8	5
416	R:R:R396	R:R:W399	9	No	No	0	5	5
417	R:R:N398	R:R:R397	7.23	No	No	0	5	7
418	R:R:N398	R:R:Q401	2.64	No	No	0	5	6
419	E:E:E29	E:E:N31	11.83	No	No	10	5	1
420	E:E:E29	E:E:Y32	2.24	No	No	10	5	6
421	E:E:N31	E:E:Y32	12.79	No	No	10	1	6
422	E:E:L80	E:E:Y32	4.69	No	No	0	5	6
423	E:E:G33	E:E:L36	1.71	No	Yes	0	3	5
424	E:E:E38	E:E:L35	3.98	No	No	0	3	3
425	E:E:L35	E:E:M76	4.24	No	Yes	0	3	4
426	E:E:L36	E:E:T73	4.42	Yes	Yes	2	5	8
427	E:E:L36	E:E:M76	5.65	Yes	Yes	0	5	4
428	E:E:F92	E:E:L36	13.4	Yes	Yes	2	5	5
429	E:E:L41	E:E:R37	6.07	Yes	Yes	2	5	4
430	E:E:F92	E:E:R37	18.17	Yes	Yes	2	5	4
431	E:E:A95	E:E:R37	2.77	No	Yes	0	3	4
432	E:E:R37	E:E:V96	5.23	Yes	No	2	4	7
433	E:E:C40	E:E:L39	3.17	Yes	No	0	9	1
434	E:E:L39	E:E:M76	4.24	No	Yes	0	1	4
435	E:E:C40	E:E:Q43	4.58	Yes	No	0	9	2
436	E:E:C40	E:E:L69	3.17	Yes	No	0	9	8
437	E:E:C40	E:E:C72	7.28	Yes	No	0	9	9
438	E:E:F44	E:E:L41	4.87	Yes	Yes	2	9	5
439	E:E:L41	E:E:L69	4.15	Yes	No	2	5	8
440	E:E:F92	E:E:L41	3.65	Yes	Yes	2	5	5
441	E:E:E68	E:E:Q43	5.1	No	No	0	3	2
442	E:E:F44	E:E:M48	14.93	Yes	Yes	2	9	9
443	E:E:F44	E:E:S65	2.64	Yes	No	2	9	5
444	E:E:F44	E:E:L69	8.53	Yes	No	2	9	8
445	E:E:F44	E:E:Y100	6.19	Yes	Yes	0	9	7
446	E:E:Q45	E:E:V46	4.3	No	No	11	4	1
447	E:E:E49	E:E:Q45	5.1	No	No	11	2	4
448	E:E:E49	E:E:V46	2.85	No	No	11	2	1
449	E:E:D47	E:E:M48	5.54	No	Yes	2	4	9
450	E:E:D47	E:E:V51	4.38	No	Yes	2	4	5
451	E:E:D47	E:E:S65	8.83	No	No	2	4	5
452	E:E:M48	E:E:W56	6.98	Yes	Yes	2	9	5
453	E:E:M48	E:E:S65	3.07	Yes	No	2	9	5
454	E:E:G52	E:E:V51	3.68	No	Yes	2	5	5
455	E:E:L55	E:E:V51	8.94	Yes	Yes	0	5	5
456	E:E:V51	E:E:W56	6.13	Yes	Yes	2	5	5
457	E:E:G52	E:E:W56	2.81	No	Yes	2	5	5
458	E:E:E53	E:E:W56	5.45	No	Yes	0	3	5
459	E:E:D58	E:E:L55	9.5	No	Yes	0	6	5
460	E:E:L55	E:E:R61	4.86	Yes	No	0	5	4
461	E:E:C57	E:E:F101	5.59	No	Yes	2	9	9
462	E:E:C104	E:E:C57	7.28	No	No	2	9	9
463	E:E:T62	E:E:W59	6.06	No	Yes	0	8	7
464	E:E:I63	E:E:W59	4.7	Yes	Yes	2	5	7
465	E:E:W59	E:E:Y66	7.72	Yes	Yes	2	7	9
466	E:E:R109	E:E:W59	5	No	Yes	2	5	7
467	E:E:G60	E:E:I63	1.76	No	Yes	0	5	5
468	E:E:I63	E:E:R67	2.51	Yes	Yes	2	5	5
469	E:E:F93	E:E:Y66	9.28	Yes	Yes	2	9	9
470	E:E:H97	E:E:Y66	3.27	Yes	Yes	2	9	9
471	E:E:D71	E:E:R67	3.57	No	Yes	0	3	5
472	E:E:A70	E:E:F93	2.77	No	Yes	0	7	9
473	E:E:D71	E:E:H75	3.78	No	No	0	3	1
474	E:E:T73	E:E:W84	8.49	Yes	Yes	2	8	7
475	E:E:F92	E:E:T73	2.59	Yes	Yes	2	5	8
476	E:E:F93	E:E:T73	5.19	Yes	Yes	2	9	8
477	E:E:A77	E:E:W74	2.59	No	No	2	8	7
478	E:E:E78	E:E:W74	20.72	No	No	0	3	7
479	E:E:W74	E:E:W84	14.99	No	Yes	2	7	7
480	E:E:E78	E:E:H75	7.39	No	No	0	3	1
481	E:E:K79	E:E:M76	7.2	No	Yes	0	1	4
482	E:E:A77	E:E:W84	3.89	No	Yes	2	8	7
483	E:E:G81	E:E:L80	1.71	No	No	0	3	5
484	E:E:P85	E:E:W84	10.81	No	Yes	2	9	7
485	E:E:V89	E:E:W84	4.9	No	Yes	2	8	7
486	E:E:P85	E:E:V89	3.53	No	No	2	9	8
487	E:E:E88	E:E:N86	13.15	No	No	0	4	9
488	E:E:N86	E:E:V89	4.43	No	No	0	9	8
489	E:E:F92	E:E:F93	6.43	Yes	Yes	2	5	9
490	E:E:F92	E:E:V96	3.93	Yes	No	2	5	7
491	E:E:V96	E:E:Y100	2.52	No	Yes	0	7	7
492	E:E:F101	E:E:H97	10.18	Yes	Yes	2	9	9
493	E:E:R99	E:E:Y100	19.55	No	Yes	0	2	7
494	E:E:F101	E:E:Y100	3.09	Yes	Yes	0	9	7
495	E:E:C104	E:E:F101	2.79	No	Yes	2	9	9
496	E:E:C104	E:E:P105	1.88	No	No	0	9	7
497	E:E:I106	E:E:S107	4.64	No	No	0	4	5
498	E:E:G108	E:E:S107	3.71	No	No	0	5	5
499	E:E:D113	E:E:R112	4.76	No	No	0	9	4
500	E:E:P114	E:E:P115	1.95	No	No	0	9	9
501	E:E:L119	E:E:P114	4.93	Yes	No	0	8	9
502	E:E:G116	E:E:L119	1.71	No	Yes	0	5	8
503	E:E:I118	E:E:S117	3.1	No	No	0	6	5
504	E:E:I123	E:E:L119	7.14	No	Yes	0	9	8
505	E:E:P126	E:E:V125	3.53	No	No	0	9	7
506	R:R:L344	R:R:P343	1.64	No	No	0	9	9
507	R:R:S155	R:R:S381	1.63	No	Yes	0	6	8
508	E:E:I127	R:R:A300	1.62	No	No	0	8	3
509	E:E:V125	E:E:V129	1.6	No	No	0	7	8
510	E:E:V137	E:E:V138	1.6	No	No	0	9	9
511	R:R:T37	R:R:V36	1.59	No	No	0	4	2
512	R:R:C299	R:R:L303	1.59	No	No	0	4	3
513	E:E:T128	E:E:V124	1.59	No	No	0	6	6
514	R:R:A138	R:R:L139	1.58	No	No	0	5	3
515	R:R:A199	R:R:L195	1.58	No	No	0	4	7
516	E:E:L131	R:R:A300	1.58	No	No	0	8	3
517	R:R:A203	R:R:N201	1.56	No	Yes	0	4	4
518	R:R:I394	R:R:S168	1.55	No	No	0	8	7
519	R:R:I153	R:R:V189	1.54	No	No	0	6	4
520	R:R:I218	R:R:V214	1.54	Yes	No	0	5	4
521	R:R:I368	R:R:V364	1.54	No	No	0	4	4
522	E:E:A87	E:E:E88	1.51	No	No	0	4	4
523	R:R:K134	R:R:T131	1.5	No	No	0	3	1
524	R:R:K136	R:R:T137	1.5	No	No	0	2	4
525	R:R:K178	R:R:T175	1.5	Yes	No	0	6	6
526	R:R:L139	R:R:V135	1.49	No	No	0	3	1
527	R:R:L310	R:R:V313	1.49	No	No	0	5	6
528	E:E:L132	E:E:V133	1.49	No	No	0	6	7
529	E:E:L136	E:E:V133	1.49	No	No	0	8	7
530	R:R:N130	R:R:V129	1.48	No	No	0	2	2
531	E:E:L55	E:E:T54	1.47	Yes	No	0	5	3
532	R:R:D94	R:R:T131	1.45	No	No	0	5	1
533	E:E:G116	E:E:Y120	1.45	No	No	0	5	5
534	E:E:E53	E:E:S103	1.44	No	No	0	3	7
535	R:R:I272	R:R:L276	1.43	No	No	0	4	3
536	R:R:I340	R:R:L339	1.43	No	Yes	0	8	7
537	R:R:I340	R:R:L344	1.43	No	No	0	8	9
538	E:E:Q43	E:E:T42	1.42	No	No	0	2	1
539	E:E:Q45	E:E:T42	1.42	No	No	0	4	1
540	E:E:K79	E:E:L80	1.41	No	No	0	1	5
541	E:E:P121	E:E:Y120	1.39	No	No	0	6	5
542	R:R:L310	R:R:L339	1.38	No	Yes	0	5	7
543	R:R:M53	R:R:Q54	1.36	Yes	No	0	2	2
544	R:R:E133	R:R:K134	1.35	Yes	No	0	1	3
545	E:E:L136	E:E:Q140	1.33	No	No	0	8	7
546	R:R:N201	R:R:Q202	1.32	Yes	No	0	4	2
547	R:R:N400	R:R:Q401	1.32	No	No	0	4	6
548	R:R:A271	R:R:W283	1.3	No	Yes	0	5	8
549	R:R:I340	R:R:R336	1.25	No	No	0	8	8
550	R:R:F257	R:R:M253	1.24	No	No	0	3	3
551	R:R:E133	R:R:H132	1.23	Yes	No	0	1	2
552	R:R:F166	R:R:N398	1.21	No	No	0	7	5
553	R:R:D106	R:R:F112	1.19	No	Yes	0	5	5
554	E:E:E88	E:E:R91	1.16	No	No	0	4	3
555	E:E:K142	E:E:W139	1.16	No	No	0	8	6
556	R:R:Q401	R:R:Y402	1.13	No	No	0	6	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M42	3.6325	4	2	3
2	R:R:Q45	7.6625	4	2	5
3	R:R:Y46	10.01	8	2	2
4	R:R:E47	6.344	5	2	6
5	R:R:C48	4.95	4	2	9
6	R:R:Y49	5.538	5	2	3
7	R:R:M53	2.415	4	0	2
8	R:R:W69	6.92333	6	2	7
9	R:R:D70	5.444	5	3	9
10	R:R:W72	5.746	5	3	5
11	R:R:L73	6.18833	6	3	5
12	R:R:W75	6.09333	6	3	9
13	R:R:V78	4.5825	4	3	7
14	R:R:C88	4.5875	4	3	9
15	R:R:Y91	6.49833	6	3	5
16	R:R:F95	6.92667	6	3	5
17	R:R:V101	2.7875	4	3	7
18	R:R:K103	9.965	4	3	8
19	R:R:W111	8.43667	6	3	9
20	R:R:F112	2.4	4	0	5
21	R:R:H114	9.7125	4	0	4
22	R:R:N123	5.6325	4	6	8
23	R:R:Y124	8.812	5	3	4
24	R:R:E133	5.2625	4	0	1
25	R:R:F142	5.65	4	0	6
26	R:R:H149	7.538	5	1	7
27	R:R:L156	4.4075	4	1	9
28	R:R:F163	4.492	5	1	7
29	R:R:Q172	7.075	4	4	7
30	R:R:I174	5.215	4	1	9
31	R:R:H177	9.39	4	0	9
32	R:R:K178	4.3625	4	1	6
33	R:R:L180	3.258	5	1	9
34	R:R:F181	3.915	6	1	8
35	R:R:F184	8.925	4	0	8
36	R:R:N187	6.1275	4	1	8
37	R:R:N201	7.21	4	0	4
38	R:R:P209	4.11	4	5	5
39	R:R:Q216	6.2075	4	0	6
40	R:R:I218	3.575	4	1	5
41	R:R:L220	6.7925	4	1	7
42	R:R:Y221	4.04	6	1	8
43	R:R:L222	3.646	5	1	5
44	R:R:N226	9.0275	4	0	8
45	R:R:Y227	5.79	6	1	8
46	R:R:F228	5.72	5	1	5
47	R:R:W229	6.45286	7	1	9
48	R:R:M230	3.4075	4	1	9
49	R:R:L231	6.34	4	0	8
50	R:R:I235	5.2625	4	0	6
51	R:R:Y236	8.614	5	4	8
52	R:R:L237	3.3275	4	0	9
53	R:R:H238	9.285	4	0	8
54	R:R:T239	5.1875	4	4	7
55	R:R:Q250	8.4175	4	4	6
56	R:R:Y255	5.446	5	4	8
57	R:R:L258	3.2225	4	0	6
58	R:R:W260	5.11	4	1	9
59	R:R:F262	6.222	5	1	4
60	R:R:P263	4.13714	7	1	9
61	R:R:H270	6.90833	6	1	8
62	R:R:R274	9.945	6	1	7
63	R:R:Y277	7.78	4	0	3
64	R:R:Y278	7.67333	6	1	6
65	R:R:C282	3.9325	4	5	9
66	R:R:W283	13.344	5	1	8
67	R:R:S285	6.53	5	1	5
68	R:R:T288	8.53333	6	1	5
69	R:R:L290	4.285	4	1	3
70	R:R:L291	6.6475	4	1	5
71	R:R:H295	6.1875	4	1	6
72	R:R:P297	4.636	5	1	8
73	R:R:I298	5.94	4	1	7
74	R:R:L339	2.485	4	0	7
75	R:R:L341	5.795	6	1	9
76	R:R:L345	4.354	5	1	9
77	R:R:E348	6.8725	4	0	8
78	R:R:F349	7.592	5	1	8
79	R:R:H370	8.15	4	1	7
80	R:R:M373	6.4625	4	1	7
81	R:R:H374	13.09	4	1	9
82	R:R:F375	5.536	5	7	7
83	R:R:V380	5.494	5	1	9
84	R:R:S381	5.28	4	1	8
85	R:R:F384	5.5375	8	1	8
86	R:R:C385	4.7125	4	1	9
87	R:R:V391	4.045	4	1	9
88	E:E:L36	6.295	4	2	5
89	E:E:R37	8.06	4	2	4
90	E:E:C40	4.55	4	0	9
91	E:E:L41	4.685	4	2	5
92	E:E:F44	7.432	5	2	9
93	E:E:M48	7.63	4	2	9
94	E:E:V51	5.7825	4	2	5
95	E:E:L55	6.1925	4	0	5
96	E:E:W56	5.3425	4	2	5
97	E:E:W59	8.705	6	2	7
98	E:E:I63	3.305	4	2	5
99	E:E:Y66	5.33333	6	2	9
100	E:E:R67	6.806	5	2	5
101	E:E:T73	5.1725	4	2	8
102	E:E:M76	5.3325	4	0	4
103	E:E:W84	8.616	5	2	7
104	E:E:F92	8.02833	6	2	5
105	E:E:F93	5.97667	6	2	9
106	E:E:H97	6.38	5	2	9
107	E:E:Y100	7.8375	4	0	7
108	E:E:F101	6.394	5	2	9
109	E:E:L119	4.73	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I41	R:R:R38	54.9308	10.02	No	No	0	6	5
2	E:E:R67	R:R:R38	54.7469	18.13	Yes	No	0	5	5
3	E:E:I63	E:E:R67	13.7848	2.51	Yes	Yes	2	5	5
4	R:R:I41	R:R:W72	53.8233	2.35	No	Yes	3	6	5
5	E:E:R67	R:R:M42	40.3519	6.2	Yes	Yes	2	5	3
6	E:E:Y66	R:R:M42	23.5157	2.39	Yes	Yes	2	9	3
7	E:E:I63	E:E:W59	13.5251	4.7	Yes	Yes	2	5	7
8	R:R:Q45	R:R:W69	10.3879	17.52	Yes	Yes	2	5	7
9	E:E:F93	R:R:Q45	17.9311	7.03	Yes	Yes	2	9	5
10	E:E:F101	R:R:Y46	12.1884	10.32	Yes	Yes	2	9	2
11	E:E:F101	E:E:H97	13.4066	10.18	Yes	Yes	2	9	9
12	R:R:W69	R:R:Y49	18.3471	3.86	Yes	Yes	2	7	3
13	E:E:F93	R:R:Y49	10.1826	5.16	Yes	Yes	2	9	3
14	R:R:W72	R:R:Y124	40.9512	15.43	Yes	Yes	3	5	4
15	R:R:D70	R:R:Y124	40.6516	10.34	Yes	Yes	3	9	4
16	R:R:D70	R:R:G71	48.5886	3.35	Yes	No	0	9	4
17	R:R:G71	R:R:W69	31.499	8.44	No	Yes	0	4	7
18	E:E:P85	R:R:G71	17.1183	4.06	No	No	0	9	4
19	R:R:F95	R:R:W72	95.2558	5.01	Yes	Yes	3	5	5
20	R:R:N123	R:R:Q126	12.3559	9.24	Yes	No	6	8	5
21	R:R:E99	R:R:Q126	13.721	6.37	No	No	0	5	5
22	R:R:C127	R:R:E99	15.9122	6.08	No	No	0	9	5
23	R:R:D94	R:R:F95	99.8332	9.55	No	Yes	3	5	5
24	R:R:E133	R:R:K134	99.9565	1.35	Yes	No	0	1	3
25	R:R:K134	R:R:T131	99.9786	1.5	No	No	0	3	1
26	R:R:D94	R:R:T131	100	1.45	No	No	0	5	1
27	R:R:E133	R:R:K136	99.8601	2.7	Yes	No	0	1	2
28	R:R:K136	R:R:T137	99.834	1.5	No	No	0	2	4
29	R:R:T137	R:R:Y367	99.8072	6.24	No	No	0	4	6
30	R:R:L141	R:R:Y367	99.7796	8.21	No	No	0	6	6
31	R:R:H370	R:R:L141	99.5394	10.29	Yes	No	1	7	6
32	R:R:H370	R:R:H374	23.597	9.55	Yes	Yes	1	7	9
33	R:R:H149	R:R:H374	21.7222	14.33	Yes	Yes	1	7	9
34	R:R:F181	R:R:V380	11.5699	3.93	Yes	Yes	1	8	9
35	R:R:L345	R:R:V380	12.3664	2.98	Yes	Yes	1	9	9
36	R:R:L345	R:R:Y227	29.9212	2.34	Yes	Yes	1	9	8
37	R:R:F349	R:R:Y227	42.2118	4.13	Yes	Yes	1	8	8
38	R:R:E348	R:R:F349	75.2066	13.99	Yes	Yes	0	8	8
39	R:R:E348	R:R:M373	75.4869	8.12	Yes	Yes	0	8	7
40	R:R:H370	R:R:M373	76.0948	3.94	Yes	Yes	1	7	7
41	R:R:H149	R:R:T191	23.2942	8.21	Yes	No	1	7	7
42	R:R:F184	R:R:N226	14.432	16.92	Yes	Yes	0	8	8
43	R:R:F184	R:R:L180	17.8775	6.09	Yes	Yes	0	8	9
44	R:R:L180	R:R:W229	18.7031	2.28	Yes	Yes	1	9	9
45	R:R:L176	R:R:Y236	12.09	4.69	No	Yes	0	9	8
46	R:R:N187	R:R:T191	15.9682	4.39	Yes	No	1	8	7
47	R:R:F349	R:R:I298	24.0922	3.77	Yes	Yes	1	8	7
48	R:R:G224	R:R:I298	24.4024	3.53	No	Yes	0	5	7
49	R:R:G224	R:R:P263	24.1668	2.03	No	Yes	0	5	9
50	R:R:G259	R:R:P263	13.6569	2.03	No	Yes	0	9	9
51	R:R:F349	R:R:H295	12.4834	13.58	Yes	Yes	1	8	6
52	R:R:H295	R:R:I294	12.0399	2.65	Yes	No	1	6	7
53	R:R:H270	R:R:I294	10.4889	6.63	Yes	No	1	8	7
54	R:R:F262	R:R:P263	10.0578	4.33	Yes	Yes	1	4	9
55	R:R:C232	R:R:W229	11.0774	5.22	No	Yes	0	7	9
56	R:R:F262	R:R:L258	10.424	3.65	Yes	Yes	0	4	6
57	R:R:L231	R:R:L258	14.1502	2.77	Yes	Yes	0	8	6
58	R:R:C232	R:R:Y255	12.3485	9.41	No	Yes	0	7	8
59	E:E:F92	E:E:F93	42.9986	6.43	Yes	Yes	2	5	9
60	E:E:F92	E:E:L41	46.8056	3.65	Yes	Yes	2	5	5
61	E:E:C40	E:E:L69	11.2912	3.17	Yes	No	0	9	8
62	E:E:L41	E:E:L69	12.3998	4.15	Yes	No	2	5	8
63	E:E:F44	E:E:L41	33.0694	4.87	Yes	Yes	2	9	5
64	E:E:F44	E:E:Y100	21.206	6.19	Yes	Yes	0	9	7
65	E:E:F101	E:E:Y100	22.9793	3.09	Yes	Yes	0	9	7
66	E:E:F44	E:E:M48	36.2273	14.93	Yes	Yes	2	9	9
67	E:E:F44	E:E:S65	15.8492	2.64	Yes	No	2	9	5
68	E:E:D47	E:E:M48	13.5885	5.54	No	Yes	2	4	9
69	E:E:D47	E:E:S65	13.5877	8.83	No	No	2	4	5
70	E:E:D47	E:E:V51	22.6497	4.38	No	Yes	2	4	5
71	E:E:V51	E:E:W56	11.3297	6.13	Yes	Yes	2	5	5
72	E:E:M48	E:E:W56	20.3839	6.98	Yes	Yes	2	9	5
73	E:E:L55	E:E:V51	27.1843	8.94	Yes	Yes	0	5	5
74	E:E:T73	E:E:W84	15.1977	8.49	Yes	Yes	2	8	7
75	E:E:P85	E:E:W84	15.5499	10.81	No	Yes	2	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7KNT

PDB Summary
PDB	7KNT
Class	B1
SubFamily	Peptide
Type	Calcitonin
SubType	CT Like
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	RAMP1
PDB Resolution	3.15
Date	2021-02-24
D.O.I.	doi.org/10.1126/science.abf7258

Net Summary
I_min	1.7
Number of Linked Nodes	428
Number of Links	556
Number of Hubs	109
Number of Links mediated by Hubs	376
Number of Communities	11
Number of Nodes involved in Communities	149
Number of Links involved in Communities	232

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	378770
Length Of Smallest Path	3
Average Path Length	24.593
Length of Longest Path	42
Minimum Path Strength	1.225
Average Path Strength	6.08021
Maximum Path Strength	26
Minimum Path Correlation	0.71
Average Path Correlation	0.964749
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	41.3156
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.4022
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • calcitonin family binding • amide binding • binding • adrenomedullin binding • peptide hormone binding • hormone binding • adrenomedullin receptor activity • calcitonin gene-related peptide receptor activity • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis
Gene Ontology	Biological Process	• developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • establishment of protein localization • nitrogen compound transport • protein transport • macromolecule localization • intracellular protein localization • regulation of vascular associated smooth muscle cell proliferation • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • response to disaccharide • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to sucrose stimulus • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • response to carbohydrate • response to sucrose • response to chemical • cellular response to disaccharide stimulus • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • membrane-bounded organelle • intracellular organelle • organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • vesicle • CGRP receptor complex • endoplasmic reticulum • calcitonin family binding • calcitonin gene-related peptide binding • amide binding • binding • peptide hormone binding • hormone binding • molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin gene-related peptide receptor activity • amylin receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular localization • establishment of protein localization • nitrogen compound transport • transport • intracellular transport • establishment of localization • localization • protein transport • establishment of localization in cell • macromolecule localization • intracellular protein localization • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • import into cell • receptor internalization • receptor-mediated endocytosis • endocytosis • vesicle-mediated transport • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • calcitonin family receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • amylin receptor signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • amylin receptor 1 signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • cell surface
SCOP2	Domain Identifier	• FnI-like domain • G protein-coupled receptor-like • RAMP1-like
SCOP2	Family Identifier	• FnI-like domain • G protein-coupled receptor-like • RAMP1-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16602
Sequence	>7KNT_Chain_R Q L G V T R N K I M T A Q Y E C Y Q K I M Q Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D N W F R H P A S N R T W T N Y T Q C N V N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F K S L S C Q R I T L H K N L F F S F V C N S V V T I I H L T A V A N N Q A L V A T N P V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V A V F A E K Q H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y N D N C W I S S D T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K N L Y M K A V R A T L I L V P L L G I E F V L I P W E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E V Q A I L R R N W N Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>7KNT_Chain_E E A N Y G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S G R A V R D P P G S I L Y P F I V V P I T V T L L V T A L V V W Q S K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	doi.org/10.1126/science.abf7258

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