Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 20.9214724
21x28 7.30754144
31x31 4.63254143
41x35 3.76429706
51x39 4.96167627
61x46 1.8025408
71x50 5.645409
81x53 2.73409
91x57 3.284207
101x60 6.8165124
112x41 3.2175406
122x42 4.665607
132x46 4.3125439
142x50 5.61539
152x57 5.73408
162x60 6.362527
172x63 7.5575425
18E1 7.19333624
19E1x50 9.66167629
20E1x52 7.568526
213x34 4.054505
223x36 4.575427
233x37 5.62527
243x50 10.0275439
253x51 7.086538
26I2x57 5.87833636
274x50 5.7175409
284x65 9.675405
29E2 29.8431023
30E2x52 8.0725424
315x43 11.98425
325x47 5.7954218
335x50 3.1325408
345x58 4.97639
355x62 5.268535
365x65 3.355438
37I3 4.903641133
386x33 3.935437
396x34 6.678536
406x43 7.275426
416x44 3.9675429
426x45 8.5854215
436x48 4.906528
446x49 5.20254215
456x51 6.46626
467x34 5.9625424
477x37 4.3275427
487x38 4.8375426
497x49 4.2725439
507x53 5.25167639
518x50 7.6365128
528x53 7.376125
53Lig 12.57592220
54G.HN.43 3.3475449
55G.S1.02 6.1754185
56G.S1.05 5.965419
57G.S1.06 3.1554158
58G.S1.07 4.375419
59G.s1h1.04 6.5519
60G.H1.04 7.34107
61G.H1.08 4.255109
62G.h1ha.04 4.9545167
63H.HA.07 4.98754165
64H.HA.16 6.966564
65H.HA.19 4.16833656
66H.HA.22 5.384556
67H.HA.23 5.1075455
68H.HA.26 6.2875407
69H.HA.29 5.19254196
70H.hahb.04 4.26254196
71H.hahb.06 6.57333654
72H.hahb.08 6.378553
73H.HB.02 7.09555
74H.HB.10 6.17401
75H.hbhc.14 4.578564
76H.HC.10 5.9825457
77H.HC.11 11.5217658
78H.hchd.01 6.525658
79H.HD.03 4.612556
80H.HD.07 10.0775454
81H.hdhe.01 8.355456
82H.hdhe.03 6.7225457
83H.HE.02 4.034507
84H.HE.04 10.115669
85H.HE.05 7.012566
86H.HE.06 8.685456
87H.HE.09 2.455405
88H.HE.11 8.744568
89H.HE.12 3.8725466
90H.hehf.04 6.91167668
91H.hehf.06 5.075469
92H.HF.03 8.648569
93H.HF.05 4.135408
94H.HF.06 9.3525466
95G.S2.06 6.79754108
96G.S3.02 6.154224
97G.S3.03 5.36254187
98G.S3.05 5.364107
99G.S3.07 5.934159
100G.S3.08 4.23333619
101G.H2.02 4.3625418
102G.H2.04 5.746519
103G.H2.06 5.25619
104G.H2.07 6.158519
105G.H2.08 5.1925418
106G.H2.09 5.8175418
107G.H2.10 4.7325417
108G.h2s4.01 5.04619
109G.S4.03 3.6325407
110G.S4.06 3.9825417
111G.s4h3.03 7.71517
112G.s4h3.04 6.50667618
113G.s4h3.05 7.324519
114G.s4h3.06 9.5725419
115G.H3.01 9.425419
116G.H3.02 4.8825418
117G.H3.06 4.906517
118G.H3.09 6.568519
119G.H3.12 4.654517
120G.H3.15 5.35718
121G.H3.17 6.21415
122G.H3.18 6.038519
123G.S5.02 3.335416
124G.S5.03 4.0325408
125G.S5.05 5.292867109
126G.S5.06 5.685418
127G.HG.08 2.236516
128G.HG.15 5.546516
129G.hgh4.02 4.33714718
130G.hgh4.05 8.3975416
131G.H4.10 8.18417
132G.H4.11 2.9175408
133G.H4.14 7.4575415
134G.H4.15 6.564519
135G.h4s6.13 3.9525417
136G.S6.02 6.26167638
137G.S6.05 7.48515
138G.H5.03 6.8545108
139G.H5.14 4.23536
140G.H5.20 3.56408
141G.H5.23 6.14667634
142G.H5.25 5.9825438
143b.lhb1x6 4.6445133
144b.lhb1x11 4.79494
145b.b1x6 7.094549
146b.l1x3 7.57571749
147b.b2x1 8.996518
148b.b2x5 6.45167647
149b.b3x2 5.7125445
150b.b3x3 5.0575478
151b.l3x2 7.6325449
152b.b4x2 5.14548
153b.b4x3 3.71167677
154b.b4x5 4.925477
155b.b4x6 8.75429749
156b.b5x3 6.01714749
157b.b5x5 5.015475
158b.b5x7 5.6225407
159b.l5x1 4.0675478
160b.l5x5 6.0925819
161b.b6x3 2.9775478
162b.b6x5 4.65667676
163b.b7x1 4.202514
164b.b7x2 3.7575478
165b.l7x2 4.13419
166b.b8x1 3.34418
167b.b8x3 3.655416
168b.b8x4 5.165676
169b.l8x1 4.0325475
170b.b9x4 5.9175409
171b.l9x3 6.82333619
172b.l9x6 6.67833618
173b.b10x3 3.39618
174b.b10x5 4.368519
175b.b11x2 4.358517
176b.b11x4 4.9619
177b.l11x1 3.38419
178b.l11x2 8.75419
179b.b12x2 5.1775417
180b.b12x6 7.67333618
181b.b13x7 8.242587
182b.l13x3 6.66789
183b.l13x6 5.514519
184b.b15x1 6.51667689
185b.b15x2 7.1975416
186b.l15x1 3.9675417
187b.l15x2 6.055489
188b.b16x4 9.434586
189b.b16x5 5.115405
190b.b16x6 7.995688
191b.b17x4 8.454265
192b.b17x7 8.8475418
193b.l17x3 8.77571719
194b.l17x6 6.99619
195b.b18x3 5.0975418
196b.l18x1 5.742867176
197b.l18x2 6.0154177
198b.b19x2 7.896516
199b.b19x4 5.8975418
200b.l19x2 6.028519
201b.b20x2 3.702516
202b.b20x4 9.62857718
203b.b20x6 6.66833616
204b.l20x2 7.8825409
205b.b21x1 10.7975417
206b.b21x6 4.5825411
207b.b21x7 5.34605
208b.l21x5 3.6465114
209b.b22x5 6.35254177
210b.b23x2 4.7475406
211b.b23x6 6.564297117
212b.l23x1 9.015406
213b.b24x3 4.07595
214b.b24x4 7.875116
215b.b24x5 3.12405
216b.b24x7 8.5054139
217b.l24x2 3.374256
218b.b25x3 7.754115
219b.l25x3 9.32499
220b.b26x3 4.07496
221b.b27x3 4.208598
222b.l27x1 11.4267619
223b.l27x2 10.64499
224b.b28x3 4.78447
225b.b28x4 6.114596
226b.b28x6 7.256599
227g.h1x11 3.355249
228g.l1x5 4.0825404
229g.h2x11 9.10254176
230g.ctx3 7.69409
231g.ctx6 4.1045136
232g.ctx15 6.895449
233g.ctx16 5.24429748
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x50 2x50 12.91276.73YesYes099
23x50 5x58 23.2598.23YesYes399
33x47 5x58 22.47245.09NoYes099
43x47 5x54 22.16974.64NoNo098
55x54 6x44 21.09735.02NoYes089
66x44 6x48 18.49525.01YesYes298
73x36 6x48 16.59553.42YesYes278
83x36 Lig 15.81434.87YesYes270
93x50 G.H5.25 38.05913.36YesYes398
106x33 G.H5.25 47.49694.28YesYes378
116x33 I3 50.46364.84YesYes373
12G.S6.02 I3 52.76313.38YesYes383
13G.H5.10 G.S6.02 55.32625.34NoYes078
14G.H5.10 G.S5.03 55.46493.25NoYes078
15G.S5.03 G.S5.05 57.20993.77YesYes089
16G.S5.05 G.s6h5.01 51.74453.89YesNo1099
17G.S5.07 G.s6h5.01 93.88097.31NoNo099
18G.S5.07 G.s5hg.01 97.53512.8NoNo099
19G.s5hg.01 H.hdhe.05 48.79994.15NoNo098
20G.s1h1.04 H.hdhe.05 48.84333.9YesNo098
21G.s1h1.04 G.s4h3.06 48.79646.37YesYes199
22G.s4h3.05 G.s4h3.06 98.13582.61YesYes199
23G.s4h3.04 G.s4h3.05 98.142711.49YesYes189
24G.HG.15 G.s4h3.04 98.40585.86YesYes168
25G.HG.15 G.hgh4.02 97.25143.65YesYes168
26G.H3.02 G.hgh4.02 97.18516.22YesYes188
27G.H3.02 G.H4.15 97.08496.22YesYes189
28G.H3.09 G.H4.15 98.99988.57YesYes199
29G.H3.09 G.S4.04 10011.79YesNo199
30G.H3.12 G.S4.04 41.83987.54YesNo179
31G.H3.12 G.H3.15 14.64294.84YesYes178
32G.H3.15 G.H3.17 14.48362.89YesYes185
33G.H2.09 G.H3.17 14.36226.35YesYes185
34G.H2.09 b.l27x1 14.40696.35YesYes189
35b.b26x1 b.l27x1 11.29914.94NoYes099
36b.b26x1 b.b26x2 11.24383.44NoNo097
37b.b26x2 b.b2x3 11.14754.86NoNo076
38b.b2x3 b.b2x5 11.09944.65NoYes067
39G.s4h3.02 G.s5hg.01 48.84453.06NoNo099
40G.s4h3.02 G.s4h3.03 48.97472.87NoYes097
41G.s4h3.03 G.s4h3.06 48.92715.29YesYes179
42G.S1.07 G.S4.04 58.17496.09YesNo199
43G.S1.07 G.S3.08 56.56072.98YesYes199
44G.H5.02 G.s6h5.05 45.70885.2NoNo049
45G.H5.01 G.H5.02 45.41645.64NoNo094
46G.H1.11 G.H5.01 45.27017.6NoNo089
47G.H1.07 G.H1.11 45.12382.74NoNo098
48G.H1.07 H.HF.05 44.97733.99NoYes098
49G.H5.03 G.s6h5.05 42.48426.73YesNo089
50H.HF.02 H.HF.05 42.84735.32NoYes068
51H.HE.04 H.HF.02 17.5465.64YesNo696
52H.HF.02 H.HF.06 25.15438.18NoYes666
53H.HE.01 H.HF.06 24.54366.59NoYes696
54H.HE.01 H.hdhe.04 24.45514.89NoNo097
55H.HE.02 H.hdhe.04 24.30383.2YesNo077
56H.HE.02 H.hdhe.03 12.62554.42YesYes077
57H.HA.26 H.hahb.04 10.64934.37YesYes076
58G.S3.08 G.s3h2.03 27.09052.98YesNo199
59G.H2.02 G.s3h2.03 27.04383YesNo189
60G.H2.02 b.l9x6 40.6155.09YesYes188
61b.l11x1 b.l9x6 26.14384.35YesYes198
62G.H2.07 G.S3.08 27.28154.9YesYes199
63G.H2.02 G.H2.07 54.24644.94YesYes189
64G.H2.04 G.H3.12 27.14653.76YesYes197
65G.H2.04 G.H2.07 27.43085YesYes199
66G.H2.02 b.l13x6 40.49344.42YesYes189
67b.l11x1 b.l13x6 25.23163.35YesYes199
68G.H2.06 b.l9x6 17.39175.97YesYes198
69G.H2.06 b.l17x6 16.75135.53YesYes199
70b.l13x6 b.l15x1 16.0313.11YesYes197
71b.l15x1 b.l17x6 15.82174.67YesYes179
72b.b11x6 b.l11x1 49.88663.71NoYes199
73b.b11x6 b.l9x3 47.468316.74NoYes199
74b.b11x4 b.l9x3 32.09455.48YesYes199
75b.b10x3 b.b11x4 24.56963.38YesYes189
76b.b10x3 b.b6x2 24.93445.07YesNo088
77b.b10x2 b.b6x2 24.66733.38NoNo068
78b.b10x2 b.b14x3 20.02813.17NoNo065
79b.b14x3 b.b15x1 19.36226.09NoYes859
80b.b15x1 b.b16x6 12.693411.02YesYes898
81b.l17x5 b.l17x6 31.96485.89NoYes169
82b.l17x5 b.l19x2 31.66365.89NoYes169
83b.l17x3 b.l19x2 18.31723.78YesYes199
84b.b19x4 b.l17x3 11.49188.21YesYes189
85b.b17x7 b.b20x6 14.909111.79YesYes186
86b.b17x7 b.b21x1 12.43084.78YesYes187
87b.b20x4 b.b20x6 13.97813.21YesYes186
88b.b10x5 b.b11x2 12.1587.54YesYes197
89b.b12x6 b.l9x3 12.71734.23YesYes189
903x50 7x53 14.94357.2YesYes399
91G.H5.03 G.s6h5.01 42.026410.24YesNo1089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2NT74.912YesYes3411
NTNT172YesYes4411
LigNT16.752YesYes0401
7x24NT7.282NoYes7421
7x31NT6.312NoYes4411
E1NT7.22YesYes4411
1x32E14.130NoYes4421
1x351x396.040YesYes6721
1x352x643.040YesNo6522
1x357x355.080YesNo6521
1x392x578.212YesYes7812
1x392x612.672YesNo7712
1x397x386.042YesYes7611
1x397x394.032YesNo7512
1x39Lig2.782YesYes7010
2x562x604.850NoYes7721
2x577x428.210YesNo8722
2x602x633.862YesYes7511
2x603x283.892YesNo7612
2x604x6532YesYes7512
2x60Lig16.212YesYes7010
2x63E110.922YesYes5411
2x63E1x5010.612YesYes5912
2x63Lig4.842YesYes5010
2x64E17.490NoYes5421
7x35E12.782NoYes5411
E1Lig10.642YesYes4010
E1x49E25.012NoYes5321
E1x50E2x5015.672YesNo9922
3x22E212.722NoYes3321
3x323x362.982NoYes6711
3x327x423.792NoNo6712
3x32Lig3.932NoYes6010
3x334x576.522NoNo4712
3x334x613.422NoNo4412
3x33Lig5.282NoYes4010
3x366x483.422YesYes7812
3x367x427.032YesNo7712
3x36Lig4.872YesYes7010
3x373x416.192YesNo7512
3x374x568.012YesNo7512
3x375x424.992YesNo7312
3x375x434.782YesYes7511
3x37Lig4.132YesYes7010
4x65E2x5217.10YesYes5421
E2E265.492YesYes3311
E2E2x505.122YesNo3912
E2Lig34.32YesYes3010
E2x51Lig4.950NoYes5010
E2E2x524.132YesYes3411
5x39E2x524.870NoYes5421
E2x52Lig6.192YesYes4010
5x36E213.082NoYes3321
6x62E218.182NoYes3321
5x436x517.862YesYes5611
5x436x5510.512YesNo5612
5x43Lig24.772YesYes5010
6x516x556.852YesNo6612
6x517x343.942YesYes6411
6x517x378.212YesYes6712
6x517x383.982YesYes6611
6x51Lig7.922YesYes6010
6x58Lig14.050NoYes4010
6x61E35.892NoNo2112
6x617x304.612NoNo2412
6x61Lig5.012NoYes2010
7x31Lig22.072NoYes4010
7x347x373.012YesYes4712
7x347x382.922YesYes4611
7x34Lig13.982YesYes4010
7x35Lig7.632NoYes5010
7x38Lig6.412YesYes6010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
100.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
100.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
95.00Consensusangiotensin_onOrthosteric Ligandat1_on
95.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
80.95Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
70.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
66.67Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
61.90Single6OS2TRV0266OS2-AT1-TRV026
61.54Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
61.54Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
61.54Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
60.87Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
60.87Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
60.87Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
60.87Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
60.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
60.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
60.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
60.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
59.26Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
59.26Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
59.26Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
59.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
58.33Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
57.69Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
57.69Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
57.14Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
57.14Single6OS1TRV0266OS1-AT1-TRV026
57.14Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
57.14Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
57.14Consensusbradykinin_onOrthosteric Ligandbk2_on
57.14Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
57.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
56.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
55.56Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
54.55Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
54.17Single4IARErgotamine4IAR-5-HT1B-Ergotamine
54.17Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
54.17Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
54.17Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
53.85Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
53.57Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
52.38Single6D26Fevipiprant6D26-DP2-Fevipiprant
52.38Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
52.38Consensusdp_offOrthosteric Liganddp2_off
52.17Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
52.17Consensuschemerin_onOrthosteric Ligandcml1_on
52.17Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
52.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
52.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
52.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
52.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
52.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
51.85Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
51.85Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
51.85Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
51.85Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
51.72Single6IGLIRL16206IGL-ETB-IRL1620
50.00Single4XT3Fractalkine4XT3-US28-Fractalkine
50.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
50.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
50.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
50.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
50.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
50.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
50.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
50.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
50.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
50.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
48.39Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
48.28Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
48.28Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
48.28Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
48.15Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.15Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
48.15Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
48.00Single8WDTphotoNECA8WDT-A2A-photoNECA
48.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
48.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
48.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
47.83Single6MXTSalmeterol6MXT-β2-Salmeterol
47.83Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
47.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
47.83Single8JJLOlodaterol8JJL-β2-Olodaterol
47.83Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
47.83Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
47.62Single6D27CAY104716D27-DP2-CAY10471
47.62Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
46.88Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
46.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
46.67Consensusendothelin_onOrthosteric Ligandetb_on eta_on
46.43Single8ZRTET-18ZRT-ETB-ET-1
46.43Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
46.43Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
46.43Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
46.43Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.15Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
46.15Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
46.15Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
46.15Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
46.15Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
46.15Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
46.15Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
46.15Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
45.83Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
45.83Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
45.83Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
45.83Consensusprostanoid_offOrthosteric Ligandep_off dp_off
45.45Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
45.45Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
45.45Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
45.45Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
45.16Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
44.44Single5WF5UK-4320975WF5-A2A-UK-432097
44.44Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
44.44Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
44.44Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
44.44Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
44.44Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
44.44Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
44.44Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
44.44Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
44.44Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
44.44Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
44.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
44.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
44.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
44.00Single7SK9CCX6627SK9-ACKR3-CCX662
44.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
44.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
44.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
44.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
44.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
43.75Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
43.48Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
43.48Single7TUYGSK682753A7TUY-GPR183-GSK682753A
43.48Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
43.48Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
43.48Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
43.48Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
43.48Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
43.48Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
43.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
43.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
43.33Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
43.33Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
43.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
43.33Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
42.86Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
42.86Single7UL3Famotidine7UL3-H2-Famotidine
42.86Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
42.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
42.86Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
42.86Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.86Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
42.86Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
42.42Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
42.31Single4XT1Fractalkine4XT1-US28-Fractalkine
42.31Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.31Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
42.31Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
42.31Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
42.31Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
42.31Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
42.31Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.94Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
41.94Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
41.67Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
41.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
41.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
41.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
41.67Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
41.67Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
41.67Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.67Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
41.67Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
41.67Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
41.67Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
41.67Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
41.67Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
41.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
41.67Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
41.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.67Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
41.67Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
41.67Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
41.67Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
41.67Consensuslpa_offOrthosteric Ligandlpa1_off
41.67Consensuslpl_offOrthosteric Ligands1p_off lpa_off
41.38Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
41.38Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
41.38Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
41.38Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
41.38Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
41.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
41.38Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
40.91Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
40.91Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
40.91Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
40.91Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
40.91Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
40.91Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
40.91Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
40.91Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
40.91Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
40.74Single3QAKUK-4320973QAK-A2A-UK-432097
40.74Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
40.74Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
40.74Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
40.74Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
40.74Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.74Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.74Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.74Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
40.62Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
40.62Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.62Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
40.62Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
40.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
40.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
40.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
40.00Single6IBLArformoterol6IBL-β1-Arformoterol
40.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
40.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
40.00Single7EZCUKA7EZC-A2A-UKA
40.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
40.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
40.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
40.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
40.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
40.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
40.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
40.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
40.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
40.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
40.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
40.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
40.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
40.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
40.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
40.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
39.39Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
39.39Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
39.39Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
39.39Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
39.29Single3OE0CVX153OE0-CXCR4-CVX15
39.29Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
39.29Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
39.29Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
39.29Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.29Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
39.29Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
39.13Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
39.13Single5C1MBU725C1M-μ-BU72
39.13Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
39.13Single7C61Ergotamine7C61-5-HT1B-Ergotamine
39.13Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
39.13Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.13Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
39.13Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
39.13Single8TF5Oleic acid8TF5-GPR6-Oleic acid
39.13Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
39.13Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
39.13Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
39.13Consensusa3_on_gpOrthosteric Liganda3a_on_gp
39.13Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
39.13Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
39.13Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
39.13Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
39.13Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
38.89Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
38.89Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
38.71Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.46Single5WF6UK-4320975WF6-A2A-UK-432097
38.46Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
38.46Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
38.46Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
38.46Single7XN9L-054,5227XN9-SST2-L-054,522
38.46Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
38.46Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
38.46Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
38.46Single8QJ2pN1628QJ2-MC4-pN162-Gs
38.46Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
38.46Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
38.46Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
38.46Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.46Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
38.46Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
38.10Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
38.10Single6AKXA4R6AKX-CCR5-A4R
38.10Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.10Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
38.10Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8GNGIstradefylline8GNG-A2A-Istradefylline
38.10Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
38.10Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
38.10Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
38.10Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
37.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
37.93Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
37.93Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
37.93Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.93Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
37.93Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
37.93Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
37.93Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
37.93Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
37.93Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
37.93Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.93Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.93Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
37.93Consensusvasop-oxy_onOrthosteric Ligandv2_on
37.93Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
37.50Single3P0GBI1671073P0G-β2-BI167107
37.50Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
37.50Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
37.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
37.50Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
37.50Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
37.50Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
37.50Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
37.50Single8E0GBU728E0G-μ-BU72
37.50Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
37.50Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
37.50Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
37.50Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
37.50Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
37.50Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
37.50Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
37.50Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
37.50Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
37.50Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
37.50Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
37.50Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
37.50Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.50Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
37.14Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
37.04Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
37.04Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
37.04Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
37.04Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
37.04Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
37.04Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
37.04Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
37.04Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
37.04Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.04Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
37.04Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.04Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.67Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
36.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
36.67Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
36.67Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
36.67Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
36.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
36.67Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
36.36Single4MBSMaraviroc4MBS-CCR5-Maraviroc
36.36Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
36.36Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
36.36Single7AROLUF58337ARO-A2A-LUF5833-Na
36.36Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
36.36Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
36.36Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
36.36Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
36.36Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
36.36Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
36.36Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
36.36Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
36.36Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
36.36Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
36.36Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
36.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
36.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
36.00Single6A93Risperidone6A93-5-HT2A-Risperidone
36.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
36.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
36.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
36.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
36.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
36.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
36.00Single8JJ8Formoterol8JJ8-β2-Formoterol
36.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
36.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
36.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
36.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
36.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
36.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
36.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
36.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
36.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
36.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
36.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
36.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
36.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensusorexin_onOrthosteric Ligandox2_on
36.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.71Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
35.71Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
35.71Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
35.71Single7SK5CXCL127SK5-ACKR3-CXCL12
35.71Single7XNACYN1548067XNA-SST2-CYN154806
35.71Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
35.71Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
35.71Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
35.71Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
35.48Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
35.48Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
35.48Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
35.48Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.48Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
35.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single4QKX35V4QKX-β2-35V
34.78Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
34.78Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
34.78Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
34.78Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
34.78Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
34.78Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
34.78Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
34.78Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
34.78Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
34.78Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
34.78Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
34.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
34.78Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
34.78Single8K5DGSK2560738K5D-HCA2-GSK256073
34.78Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
34.78Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
34.78Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
34.78Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
34.78Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
34.78Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
34.78Single9CHXS-Carazolol9CHX-β2-S-Carazolol
34.78Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
34.78Consensus5ht5_onOrthosteric Ligand5ht5a_on
34.78Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
34.78Consensusa3_onOrthosteric Liganda3a_on
34.78Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
34.78Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
34.78Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
34.78Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
34.78Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
34.78Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Consensushca_on_gpOrthosteric Ligandhca2_on_gp
34.62Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
34.62Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
34.62Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
34.62Single6H7LDobutamine6H7L-β1-Dobutamine
34.62Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
34.62Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
34.62Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
34.62Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
34.62Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
34.62Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
34.62Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
34.62Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
34.62Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
34.62Consensuscck_onOrthosteric Ligandccka_on cckb_on
34.62Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
34.62Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
34.62Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
34.48Single6PT2KGCHM076PT2-δ-KGCHM07
34.48Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.48Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
34.48Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
34.48Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
34.48Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
34.48Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.48Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
34.48Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.38Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
34.38Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
34.38Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
34.38Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
33.33Single2Y00Dobutamine2Y00-β1-Dobutamine
33.33Single3NY9ICI118-5513NY9-β2-ICI118-551
33.33Single3OE9IT1t3OE9-CXCR4-IT1t
33.33Single4UG2CGS216804UG2-A2A-CGS21680
33.33Single5N2RPSB-365N2R-A2A-PSB-36-Na
33.33Single5N2SPSB365N2S-A1-PSB36
33.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
33.33Single5WIUNemonapride5WIU-D4-Nemonapride
33.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
33.33Single6E67BI1671076E67-β2-BI167107-Gs (fused)
33.33Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
33.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
33.33Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
33.33Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
33.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
33.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
33.33Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
33.33Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
33.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
33.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
33.33Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
33.33Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
33.33Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
33.33Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
33.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8JXSPF-61428JXS-D1-PF-6142
33.33Single8S4DCMF-0198S4D-Apelin-CMF-019
33.33Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
33.33Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
33.33Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
33.33Single8X5YAstemizole8X5Y-H1-Astemizole
33.33Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
33.33Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
33.33Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
33.33Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
33.33Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
33.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
33.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
33.33Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
33.33Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
33.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
33.33Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
33.33Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
33.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
33.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
33.33Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
33.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
33.33Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
33.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrace-amine_onOrthosteric Ligandta1_on
32.35Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
32.35Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
32.35Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbombesin_onOrthosteric Ligandbb2_on
32.35Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
32.35Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.26Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
32.26Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
32.26Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
32.26Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
32.26Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
32.14Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
32.14Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
32.14Single7F8XNN90567F8X-CCKA-NN9056
32.14Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
32.14Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
32.14Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.14Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
32.14Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
32.14Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.14Single8XWNCXCL88XWN-CXCR2-CXCL8
32.14Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
32.14Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
32.14Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
32.14Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensussomatostatin_offOrthosteric Ligandsst2_off
32.00Single2YDVNECA2YDV-A2A-NECA
32.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
32.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
32.00Single4UHRCGS216804UHR-A2A-CGS21680
32.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
32.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
32.00Single5G53NECA5G53-A2A-NECA-Gs
32.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
32.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
32.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
32.00Single6WGTLSD6WGT-5-HT2A-LSD
32.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
32.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
32.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
32.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
32.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
32.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
32.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
32.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
32.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
32.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
32.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
32.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
32.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
32.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
32.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
32.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
32.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
32.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
32.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
32.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
32.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
32.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
32.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
32.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
32.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
32.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
32.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
32.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
32.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
32.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
32.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
32.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
32.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
32.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
32.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
32.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
32.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
32.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
32.00Consensuslpa_onOrthosteric Ligandlpa1_on
32.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
32.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
32.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
32.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
31.82Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
31.82Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
31.82Single6ME9Ramelteon6ME9-MT2-Ramelteon
31.82Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
31.82Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
31.82Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
31.82Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
31.82Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
31.82Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
31.82Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
31.82Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
31.82Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
31.82Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
31.82Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
31.82Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
31.82Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
31.82Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
31.82Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
31.82Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
31.82Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
31.82Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
31.82Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
31.82Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
31.82Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
31.82Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
31.82Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.82Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
31.25Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
31.25Single7SK3CXCL127SK3-ACKR3-CXCL12
31.25Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
31.25Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
31.03Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
31.03Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
31.03Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
31.03Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
31.03Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.03Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
30.77Single3D4STimolol3D4S-β2-Timolol
30.77Single4AMIBucindolol4AMI-β1-Bucindolol
30.77Single4LDEBI1671074LDE-β2-BI167107
30.77Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
30.77Single6ZG4HTL00099366ZG4-M1-HTL0009936
30.77Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
30.77Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
30.77Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
30.77Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
30.77Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.77Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.77Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
30.77Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
30.77Single7YITNalfurafine7YIT-κ-Nalfurafine
30.77Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
30.77Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
30.77Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
30.77Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
30.77Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
30.77Single8JWY2-1188JWY-A2A-2-118
30.77Single8JWZAB9288JWZ-A2A-AB928-Na
30.77Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
30.77Single8XYIVUF106618XYI-CXCR3-VUF10661
30.77Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
30.77Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
30.77Consensusalpha1_offOrthosteric Ligandalpha1a_off
30.77Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
30.77Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
30.77Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
30.77Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
30.77Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
30.77Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
30.77Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.77Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
30.43Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
30.43Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
30.43Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
30.43Single6KUXRS-799486KUX-α2a-RS-79948
30.43Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
30.43Single6MH8ZM-2413856MH8-A2A-ZM-241385
30.43Single6PS0S-Carazolol6PS0-β2-S-Carazolol
30.43Single6PS4ICI118-5516PS4-β2-ICI118-551
30.43Single6PS5S-Propranolol6PS5-β2-S-Propranolol
30.43Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
30.43Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
30.43Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
30.43Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
30.43Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single7T32ZM-2413857T32-A2A-ZM-241385
30.43Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
30.43Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
30.43Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
30.43Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
30.43Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
30.43Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
30.43Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
30.43Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
30.43Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
30.43Single8IHKAcifran8IHK-HCA3-Acifran
30.43Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
30.43Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
30.43Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
30.43Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
30.43Single8K5CAcipimox8K5C-HCA2-Acipimox
30.43Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
30.43Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
30.43Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
30.43Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
30.43Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
30.43Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
30.43Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
30.43Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
30.43Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
30.43Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
30.43Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.43Consensushca_onOrthosteric Ligandhca2_on
30.43Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
30.30Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
30.30Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
30.30Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
30.30Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
30.30Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
30.30Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
30.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
30.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
30.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
30.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.63Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
29.63Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
29.63Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
29.63Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.63Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
29.63Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
29.63Single7UM4AS26747237UM4-5-HT5A-AS2674723
29.63Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
29.63Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
29.63Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
29.63Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
29.63Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
29.63Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
29.63Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
29.63Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.63Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
29.63Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
29.63Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.63Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.63Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.63Consensusendothelin_offOrthosteric Ligandetb_off
29.63Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
29.63Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
29.63Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
29.63Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
29.41Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
29.41Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
29.41Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
29.41Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
29.17Single2Y01Dobutamine2Y01-β1-Dobutamine
29.17Single2Y02Carmoterol2Y02-β1-Carmoterol
29.17Single2Y04Salbutamol2Y04-β1-Salbutamol
29.17Single3NY8ICI118-5513NY8-β2-ICI118-551
29.17Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
29.17Single4EJ4Naltrindole4EJ4-δ-Naltrindole
29.17Single4GBRS-Carazolol4GBR-β2-S-Carazolol
29.17Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
29.17Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
29.17Single5UENDU1725UEN-A1-DU172
29.17Single5UIGCmpd-15UIG-A2A-Cmpd-1
29.17Single6DRXLisuride6DRX-5-HT2B-Lisuride
29.17Single6H7MSalbutamol6H7M-β1-Salbutamol
29.17Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
29.17Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
29.17Single6PS1Timolol6PS1-β2-Timolol
29.17Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
29.17Single6TOTLemborexant6TOT-OX1-Lemborexant
29.17Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
29.17Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
29.17Single7BU7BI1671077BU7-β1-BI167107
29.17Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
29.17Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
29.17Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
29.17Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
29.17Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
29.17Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.17Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
29.17Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
29.17Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
29.17Single7UL4Alvimopan7UL4-μ-Alvimopan
29.17Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
29.17Single7V3ZCP559407V3Z-CB1-CP55940
29.17Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
29.17Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
29.17Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
29.17Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Single7WC7Lisuride7WC7-5-HT2A-Lisuride
29.17Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
29.17Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
29.17Single8CU6LJ-45178CU6-A2A-LJ-4517
29.17Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
29.17Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
29.17Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
29.17Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
29.17Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
29.17Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
29.17Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
29.17Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.17Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
29.17Single8JXRLSD8JXR-D1-LSD
29.17Single8T1WCVN4248T1W-GPR6-CVN424
29.17Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
29.17Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.17Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
29.17Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
29.17Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
29.17Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
29.17Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
29.17Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
29.17Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensusblt_onOrthosteric Ligandblt1_on
29.17Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
29.17Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.17Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
29.17Consensusdopamine_offOrthosteric Ligandd2_off d3_off
29.17Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
29.17Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
29.17Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
29.17Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
29.17Consensusleukotriene_onOrthosteric Ligandblt_on
29.17Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
29.17Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
29.03Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.03Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
28.57Single3OE6IT1t3OE6-CXCR4-IT1t
28.57Single5EE7MK08935EE7-Glucagon-MK0893
28.57Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
28.57Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
28.57Single5ZTYAM102575ZTY-CB2-AM10257
28.57Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
28.57Single6KNMJN241-96KNM-Apelin-JN241-9
28.57Single6ME5Agomelatine6ME5-MT1-Agomelatine
28.57Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
28.57Single6PT3DPI-2876PT3-δ-DPI-287
28.57Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
28.57Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
28.57Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
28.57Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
28.57Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
28.57Single8XQJJN2418XQJ-Apelin-JN241
28.57Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
28.57Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
28.57Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
28.57Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
28.12Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
28.12Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.12Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
28.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
28.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
28.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
28.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
28.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
28.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
28.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
28.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
28.00Single5TVNLSD5TVN-5-HT2B-LSD
28.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
28.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
28.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
28.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
28.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
28.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
28.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
28.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
28.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
28.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
28.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
28.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
28.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
28.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
28.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
28.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
28.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
28.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
28.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
28.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
28.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
28.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
28.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
28.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
28.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
28.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
28.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
28.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
28.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
28.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
28.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
28.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
28.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
28.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
28.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
28.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
28.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
28.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
27.59Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
27.59Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
27.59Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
27.59Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.59Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
27.59Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.59Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.50Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
27.27Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
27.27Single6FJ3PTH6FJ3-PTH1-PTH
27.27Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
27.27Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
27.27Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
27.27Single7SRQLSD7SRQ-5-HT2B-LSD
27.27Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.27Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
27.27Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
27.27Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
27.27Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
27.27Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
27.27Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
27.27Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
27.27Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
27.27Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
27.27Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
27.27Single8K5BNiacin8K5B-HCA2-Niacin
27.27Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
27.27Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.27Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
27.27Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
27.27Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
27.27Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
27.27Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
27.27Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
27.27Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
27.03Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
27.03Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
27.03Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
26.92Single4U15Tiotropium4U15-M3-Tiotropium
26.92Single5D5AS-Carazolol5D5A-β2-S-Carazolol
26.92Single5D5BS-Carazolol5D5B-β2-S-Carazolol
26.92Single5V54Methiothepin5V54-5-HT1B-Methiothepin
26.92Single5XR8AM8415XR8-CB1-AM841
26.92Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
26.92Single6H7JIsoprenaline6H7J-β1-Isoprenaline
26.92Single6J21Aprepitant6J21-NK1-Aprepitant
26.92Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
26.92Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
26.92Single6OL9Tiotropium6OL9-M5-Tiotropium
26.92Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
26.92Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
26.92Single7PX4PSB-21137PX4-A2A-PSB-2113
26.92Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
26.92Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
26.92Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.92Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
26.92Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
26.92Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
26.92Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
26.92Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.92Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
26.92Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
26.92Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
26.92Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
26.92Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
26.92Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
26.92Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.92Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
26.92Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
26.92Consensus5ht1_offOrthosteric Ligand5ht1b_off
26.92Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
26.92Consensusa2_onOrthosteric Liganda2b_on
26.92Consensusa2_on_gpOrthosteric Liganda2b_on_gp
26.92Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.92Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.92Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
26.92Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.92Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
26.92Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
26.92Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
26.67Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.67Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
26.67Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
26.67Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.47Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
26.09Single3ODUIT1t3ODU-CXCR4-IT1t
26.09Single3PWHZM-2413853PWH-A2A-ZM-241385
26.09Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
26.09Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
26.09Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.09Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.09Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
26.09Single6ME2Ramelteon6ME2-MT1-Ramelteon
26.09Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
26.09Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.09Single7BR3Elagolix7BR3-GnRH1-Elagolix
26.09Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
26.09Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
26.09Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
26.09Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
26.09Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
26.09Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
26.09Single7XRRLemborexant7XRR-OX2-Lemborexant
26.09Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
26.09Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
26.09Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
26.09Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
26.09Single8IWESpermidine8IWE-TA9-Spermidine
26.09Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
26.09Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
26.09Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
26.09Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
26.09Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
26.09Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
26.09Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.09Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
26.09Consensusalpha2_offOrthosteric Ligandalpha2c_off
26.09Consensusangiotensin_offOrthosteric Ligandat1_off
26.09Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
26.09Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
26.09Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
26.09Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
26.09Consensusorexin_offOrthosteric Ligandox2_off ox1_off
26.09Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
26.09Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.09Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.09Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.09Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
26.09Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
26.09Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.93Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.93Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.93Single4XESNeurotensin4XES-NTS1-Neurotensin
25.93Single5CXVTiotropium5CXV-M1-Tiotropium
25.93Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.93Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
25.93Single6CM4Risperidone6CM4-D2-Risperidone
25.93Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.93Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.93Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
25.93Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.93Single7DFPSpiperone7DFP-D2-Spiperone
25.93Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
25.93Single7K15MKD0467K15-BLT1-MKD046-Na
25.93Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.93Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
25.93Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
25.93Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
25.93Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
25.93Single8XQJJN2418XQJ-Apelin-JN241
25.93Single8XWACXCL18XWA-CXCR2-CXCL1
25.93Single8XWMCXCL68XWM-CXCR2-CXCL6
25.93Single8XWSCXCL58XWS-CXCR2-CXCL5
25.93Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
25.93Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.93Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
25.93Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.93Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
25.93Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
25.93Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
25.93Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.93Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.93Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.81Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
25.81Single6W25SHU91196W25-MC4-SHU9119-Ca
25.81Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
25.81Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.81Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.81Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.71Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
25.71Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
25.00Single2YDOAdenosine2YDO-A2A-Adenosine
25.00Single3REYXAC3REY-A2A-XAC
25.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
25.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
25.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
25.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
25.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
25.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
25.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
25.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
25.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
25.00Single5X93K-87945X93-ETB-K-8794
25.00Single6A94Zotepine6A94-5-HT2A-Zotepine
25.00Single6AQFZM-2413856AQF-A2A-ZM-241385
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
25.00Single6TPGEMPA6TPG-OX2-EMPA
25.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
25.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
25.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
25.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
25.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
25.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
25.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
25.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
25.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
25.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
25.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
25.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
25.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
25.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
25.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
25.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
25.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
25.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
25.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
25.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
25.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
25.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
25.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.00Single8XVUCXCL28XVU-CXCR2-CXCL2
25.00Single8XWFCXCL38XWF-CXCR2-CXCL3
25.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
25.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
25.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
25.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
25.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
25.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
25.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
25.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
25.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
25.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
25.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
25.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
25.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusgrh_offOrthosteric Ligandgnrh1_off
25.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
25.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
24.32Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
24.32Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
24.32Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
24.24Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
24.24Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
24.24Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
24.14Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
24.14Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
24.14Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
24.14Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.14Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
24.14Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
24.14Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
24.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
24.00Single3EMLZM-2413853EML-A2A-ZM-241385
24.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
24.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
24.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
24.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
24.00Single4MQSIperoxo4MQS-M2-Iperoxo
24.00Single4QIMANTA XV4QIM-SMO-ANTA XV
24.00Single4U14Tiotropium4U14-M3-Tiotropium
24.00Single4YAYZD-71554YAY-AT1-ZD-7155
24.00Single5DHHSB-6121115DHH-NOP-SB-612111
24.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
24.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
24.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
24.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
24.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
24.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
24.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
24.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
24.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
24.00Single6S0LZM-2413856S0L-A2A-ZM-241385
24.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
24.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
24.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
24.00Single7PYRPSB-21157PYR-A2A-PSB-2115
24.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
24.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
24.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
24.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
24.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
24.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
24.00Single8JJOAlprenolol8JJO-β2-Alprenolol
24.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
24.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
24.00Single8RLNLUF58348RLN-A2A-LUF5834
24.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
24.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
24.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
24.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
24.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
24.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
24.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
24.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
24.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
24.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
24.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
24.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
24.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
23.81Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.81Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.81Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
23.81Single9CHUNoradrenaline9CHU-β2-Noradrenaline
23.81Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.81Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.81Consensusp2y_offOrthosteric Ligandp2y1_off
23.68Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
23.68Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
23.53Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
23.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
23.33Single7QA8Peptide7QA8-STE2-Peptide
23.33Single7QA8Peptide7QA8-STE2-Peptide
23.33Single8WKYPG-9348WKY-MC4-PG-934
23.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
23.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
23.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.08Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.08Single5WQCEMPA5WQC-OX2-EMPA
23.08Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.08Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.08Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
23.08Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
23.08Single6LUQHaloperidol6LUQ-D2-Haloperidol
23.08Single6PS6Timolol6PS6-β2-Timolol
23.08Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.08Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
23.08Single6TP6Filorexant6TP6-OX1-Filorexant
23.08Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.08Single7C4SS1P7C4S-S1P3-S1P
23.08Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.08Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
23.08Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
23.08Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
23.08Single7WC6LSD7WC6-5-HT2A-LSD
23.08Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
23.08Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.08Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.08Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
23.08Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
23.08Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
23.08Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
23.08Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.08Single8QOTNanobody-E8QOT-μ-Nanobody-E
23.08Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
23.08Single8ZMFA1L108ZMF-5-HT2C-A1L10
23.08Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.08Consensusep_offOrthosteric Ligandep4_off
23.08Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.08Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
23.08Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.08Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
22.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
22.73Single4XNWMRS25004XNW-P2Y1-MRS2500
22.73Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
22.73Single7WC5Psilocin7WC5-5-HT2A-Psilocin
22.73Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
22.73Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.73Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
22.73Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
22.73Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
22.73Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
22.73Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.73Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
22.73Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
22.73Consensus5ht2_onOrthosteric Ligand5ht2b_on
22.73Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
22.73Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
22.73Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
22.73Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
22.73Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
22.73Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
22.73Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
22.58Single6HLOAprepitant6HLO-NK1-Aprepitant
22.58Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
22.58Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
22.58Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
22.58Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
22.50Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
22.22Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
22.22Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
22.22Single4DJHJDTic4DJH-κ-JDTic
22.22Single5TZRMK86665TZR-FFA1-MK8666
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
22.22Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
22.22Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.22Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.22Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.22Single6TQ7SB-3348676TQ7-OX1-SB-334867
22.22Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
22.22Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
22.22Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
22.22Single7FEECP559407FEE-CB1-CP55940-ZCZ011
22.22Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single7R0CAVP7R0C-V2-AVP-Arrestin2
22.22Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
22.22Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
22.22Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
22.22Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.22Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
22.22Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
22.22Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
22.22Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
22.22Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8XVLZibotentan8XVL-ETA-Zibotentan
22.22Single9BJKNAM9BJK-μ-Naloxone-NAM
22.22Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
22.22Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
22.22Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
22.22Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.22Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
22.22Consensusneurotensin_onOrthosteric Ligandnts1_on
22.22Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.22Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.88Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.74Single3PBLEticlopride3PBL-D3-Eticlopride
21.74Single4O9RCyclopamine4O9R-SMO-Cyclopamine
21.74Single6HLLCP999946HLL-NK1-CP99994
21.74Single6LI0C176LI0-GPR52-C17
21.74Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.74Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
21.74Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.74Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
21.74Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
21.74Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.74Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
21.74Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
21.74Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
21.74Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
21.74Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
21.74Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
21.74Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
21.74Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
21.74Single9B9Y7DY9B9Y-CB1-7DY
21.74Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.74Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
21.74Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
21.74Consensusgq_nucleotideOrthosteric Ligandgq_p2y
21.74Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.74Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.62Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.62Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
21.43Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
21.43Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
21.43Single4N4WSANT-14N4W-SMO-SANT-1
21.43Single6KQICP559406KQI-CB1-CP55940-Org27569
21.43Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.43Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
21.43Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.43Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
21.43Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
21.43Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
21.43Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
21.43Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.43Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.21Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.21Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.21Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.21Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.05Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
20.83Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
20.83Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
20.83Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
20.83Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
20.83Single4BWBNeurotensin4BWB-NTS1-Neurotensin
20.83Single4QINSAG1.54QIN-SMO-SAG1.5
20.83Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.83Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.83Single5U09Taranabant5U09-CB1-Taranabant
20.83Single5WS3EMPA5WS3-OX2-EMPA
20.83Single6B73MP11046B73-κ-MP1104
20.83Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
20.83Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.83Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.83Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
20.83Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.83Single6TODEMPA6TOD-OX1-EMPA-Na
20.83Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
20.83Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
20.83Single7F8ULintitript7F8U-CCKA-Lintitript
20.83Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
20.83Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
20.83Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.83Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
20.83Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
20.83Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.83Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
20.83Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
20.83Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
20.83Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.83Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
20.83Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
20.83Single8Y0HVUF114188Y0H-CXCR3-VUF11418
20.83Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
20.83Single9BA0A1AKN9BA0-CB1-A1AKN
20.83Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
20.83Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
20.83Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
20.83Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
20.83Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
20.69Single6K1QIRL25006K1Q-ETB-IRL2500
20.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.69Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
20.69Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.69Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
20.69Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
20.69Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.69Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.59Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.51Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
20.00Single3RZECidoxepin3RZE-H1-Cidoxepin
20.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5JTBZM-2413855JTB-A2A-ZM-241385
20.00Single5UVIZM-2413855UVI-A2A-ZM-241385
20.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
20.00Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TPNHTL66416TPN-OX2-HTL6641
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6VI4JDTic6VI4-κ-JDTic
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
20.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
20.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
20.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
20.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
20.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
20.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
20.00Single8K2WAMG4878K2W-CXCR3-AMG487
20.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
20.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
20.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
20.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
20.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
20.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
20.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
20.00Consensusa2_offOrthosteric Liganda2a_off
20.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
20.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
20.00Consensussensory_offOrthosteric Ligandopsins_off
19.44Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
19.44Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
19.44Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
19.44Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
19.44Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
19.44Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
19.35Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
19.35Single8IEBA1LYA8IEB-GPR156-A1LYA
19.35Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.35Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
19.35Single8KIGSHU91198KIG-MC3-SHU9119-Ca
19.23Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
19.23Single4DAJTiotropium4DAJ-M3-Tiotropium
19.23Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
19.23Single5DHGC-355DHG-NOP-C-35
19.23Single5TGZAM65385TGZ-CB1-AM6538
19.23Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
19.23Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
19.23Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
19.23Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
19.23Single6GPSMK08126GPS-CCR2-MK0812
19.23Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
19.23Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.23Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
19.23Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
19.23Single7YXAONO-54306087YXA-S1P5-ONO-5430608
19.23Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.23Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
19.23Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
19.23Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
19.23Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
19.23Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.23Single8X63Mepyramine8X63-H1-Mepyramine
19.23Single8X64Desloratadine8X64-H1-Desloratadine
19.23Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
19.23Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
19.23Single9IYAONO-97105319IYA-GPR55-ONO-9710531
19.23Consensuscck_offOrthosteric Ligandccka_off
19.23Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.23Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
19.23Consensushistamine_offOrthosteric Ligandh1_off
19.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
19.05Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
19.05Single7WC4Serotonin7WC4-5-HT2A-Serotonin
19.05Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
19.05Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
19.05Single8PWNTheophylline8PWN-A2A-Theophylline
18.92Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.92Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
18.75Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
18.75Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.75Single8IEBA1LYA8IEB-GPR156-A1LYA
18.75Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.75Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single4JKVTaladegib4JKV-SMO-Taladegib
18.52Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
18.52Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
18.52Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
18.52Single5XPRBosentan5XPR-ETB-Bosentan
18.52Single6GPXMK08126GPX-CCR2-MK0812
18.52Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
18.52Single7W41PD1762527W41-BB2-PD176252
18.52Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
18.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.52Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
18.52Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
18.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
18.52Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
18.52Consensusblt_offOrthosteric Ligandblt1_off
18.52Consensusbombesin_offOrthosteric Ligandbb2_off
18.52Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
18.52Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
18.18Single3OE8IT1t3OE8-CXCR4-IT1t
18.18Single3RFMCaffeine3RFM-A2A-Caffeine
18.18Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
18.18Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
18.18Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
18.18Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
18.18Consensussensory_onOrthosteric Ligandopsins_on
17.95Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.95Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.86Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.86Single5V56TC1145V56-SMO-TC114
17.86Single5V57TC1145V57-SMO-TC114
17.86Single6J20Aprepitant6J20-NK1-Aprepitant
17.86Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.86Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8EA0Iperoxo8EA0-M3-Iperoxo
17.86Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.86Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
17.86Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
17.86Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.86Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.86Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
17.86Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
17.86Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.86Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.86Consensustachykinin_offOrthosteric Ligandnk1_off
17.78Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
17.65Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.65Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.39Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.39Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
17.39Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.39Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
17.39Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
17.39Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
17.39Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
17.39Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.39Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.24Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.24Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
17.24Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.24Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.24Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.24Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.24Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
17.24Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.24Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.24Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.14Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
17.14Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.07Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
17.07Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
16.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
16.67Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
16.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
16.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
16.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
16.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
16.67Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
16.67Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
16.67Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
16.67Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.13Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.13Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.13Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
16.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
16.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
16.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
16.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
16.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
16.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
16.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
16.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
16.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
16.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
16.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
16.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
15.79Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.62Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
15.62Single8IEIA1LYA8IEI-GPR156-A1LYA
15.62Single8IEPA1LYA8IEP-GPR156-A1LYA
15.62Single8IEPA1LYA8IEP-GPR156-A1LYA
15.62Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.38Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
15.38Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.38Single6ZINSR486926ZIN-NTS1-SR48692
15.38Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.38Single7VODCariprazine7VOD-5-HT2A-Cariprazine
15.38Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.81Single5DSGTiotropium5DSG-M4-Tiotropium
14.81Single5T04Neurotensin5T04-NTS1-Neurotensin
14.81Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.81Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.81Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.81Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
14.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.81Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
14.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.81Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
14.81Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
14.81Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
14.81Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
14.81Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.29Single5CGCHTL142425CGC-mGlu5-HTL14242
14.29Single5MZPCaffeine5MZP-A2A-Caffeine-Na
14.29Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
14.29Single6HLPNetupitant6HLP-NK1-Netupitant
14.29Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.29Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
14.29Single6Z4SSR486926Z4S-NTS1-SR48692
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
14.29Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.89Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.79Single6E59L-7607356E59-NK1-L-760735
13.79Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.79Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.79Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.79Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
13.79Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
13.64Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
13.64Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.64Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
13.64Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.33Single5X33BIIL2605X33-BLT1-BIIL260
13.33Single6IIURamatroban6IIU-TP-Ramatroban
13.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
13.33Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.33Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.33Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.16Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.04Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
13.04Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.04Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.04Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.04Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
12.90Single5CGDHTL142425CGD-mGlu5-HTL14242
12.90Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3UZAGTPL92363UZA-A2A-GTPL9236
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8IEIA1LYA8IEI-GPR156-A1LYA
12.50Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Single8JPSCCL78JPS-ACKR1-CCL7
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusgi_sensoryOrthosteric Ligandgi_opsins
12.50Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.12Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.12Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
12.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
12.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
12.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
12.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.54Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.54Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.54Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.54Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.54Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.54Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.54Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.54Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.54Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.54Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.11Single6TPKRetosiban6TPK-OT-Retosiban
11.11Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.11Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.11Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
11.11Consensusvasop-oxy_offOrthosteric Ligandot_off
10.71Single6IIVDaltroban6IIV-TP-Daltroban
10.71Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.71Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.34Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.34Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.34Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.34Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.34Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
9.09Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
8.70Single8HS2Fab0468HS2-GPR20-Fab046
8.33Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
8.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
8.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single7UL2SR486927UL2-NTS1-SR48692-Na
7.69Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
7.69Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.69Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_offOrthosteric Ligandnts1_off
7.69Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
7.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.41Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
7.41Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
7.41Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single6FFIMMPEP6FFI-mGlu5-MMPEP
7.14Single7VV6C48/807VV6-MRGPRX2-C48/80
7.14Single8IYXYL-3658IYX-GPR34-YL-365
6.90Single6FFHFenobam6FFH-mGlu5-Fenobam
6.67Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
6.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single7P2L4YI7P2L-mGlu5-4YI
6.45Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.45Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.45Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
6.06Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
5.71Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7SHEPI; PE7SHE-GPR158-PI; PE
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6D35Cholesterol6D35-SMO-Cholesterol
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.00Single7XW7K1-707XW7-TSH-K1-70
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WVXNorrin8WVX-LGR4-Norrin
5.00Single8WVYNorrin8WVY-LGR4-Norrin
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.55Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.35Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.35Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.35Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.35Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.35Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.17Single5L7DCholesterol5L7D-SMO-Cholesterol
4.17Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.17Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.85Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.85Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.70Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.70Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.70Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.70Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.23Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.23Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.23Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.23Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.12Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.12Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.03Single7SHEPI; PE7SHE-GPR158-PI; PE
2.78Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.78Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.63Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.56Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.38Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
7F6G 7F6G-AT1-SAR1-AngII-Gq/β1/γ2
Net Summary
Imin 2.61
Number of Linked Nodes 960
Number of Links 1269
Number of Hubs 233
Number of Links mediated by Hubs 844
Number of Communities 27
Number of Nodes involved in Communities 363
Number of Links involved in Communities 570
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 4185667
Length Of Smallest Path 3
Average Path Length 37.301
Length of Longest Path 63
Minimum Path Strength 1.21
Average Path Strength 5.92908
Maximum Path Strength 46.545
Minimum Path Correlation 0.7
Average Path Correlation 0.993076
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 36.0122
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 63.7034
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gq_peptidegq_cck
gq_kisspeptin
gq_bradykinin
gq_bombesin
gq_angiotensin



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Download gq_angiotensin.zip



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