Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1b.h2x1 3.08405
2b.h2x5 4.48875485
3b.lhb1x3 3.615482
4b.lhb1x6 4.821583
5b.lhb1x9 3.37875403
6b.b1x6 4.6225459
7b.l1x3 10.182559
8b.b2x1 6.13357718
9b.b2x3 4.00375406
10b.b2x5 8.0025407
11b.b3x1 5.28625475
12b.b3x4 5.48875459
13b.l3x2 5.03875409
14b.b4x4 8.41875458
15b.b4x5 5.38875477
16b.b4x6 7.905659
17b.b4x7 6.67875478
18b.b5x2 4.532577
19b.b5x3 6.245759
20b.b5x5 5.56875475
21b.b5x7 6.63875407
22b.l5x1 5.2275228
23b.l5x5 8.209519
24b.b6x5 4.86313876
25b.l6x5 5.7975494
26b.b7x1 5.71594
27b.l7x2 4.489519
28b.l7x4 3.205409
29b.b8x4 6.6075226
30b.l8x5 4.755493
31b.b9x4 4.807509
32b.l9x3 7.18256109
33b.l9x6 5.33286718
34b.b10x3 3.43875408
35b.b10x5 3.48625409
36b.l10x1 4.324503
37b.b11x3 4.14875465
38b.b11x4 4.5154109
39b.l11x2 7.05754109
40b.b12x6 8.549176108
41b.b13x7 7.276567
42b.l13x3 7.61583669
43b.l13x6 5.744519
44b.b14x1 3.565418
45b.b14x3 4.91465
46b.b15x1 6.683569
47b.b15x2 5.2475446
48b.l15x1 4.11417617
49b.b16x4 9.3275466
50b.b16x5 3.585405
51b.b16x6 8.41214768
52b.b17x4 4.046254205
53b.b17x5 7.05375447
54b.b17x7 9.725448
55b.l17x3 7.53125849
56b.l17x6 6.413519
57b.l17x7 4.7325447
58b.b18x3 4.826548
59b.b18x5 5.94405
60b.l18x1 5.240836166
61b.b19x2 6.4975646
62b.b19x4 6.0525448
63b.l19x2 4.905449
64b.b20x2 4.629546
65b.b20x4 10.993548
66b.b20x6 6.53746
67b.b21x1 9.67125447
68b.b21x4 4.3375405
69b.b21x5 4.2925404
70b.b21x7 6.431505
71b.l21x2 6.401254114
72b.l21x5 3.931254114
73b.b22x5 6.8356167
74b.l22x5 6.095689
75b.b23x1 3.8154195
76b.b23x6 5.6757117
77b.l23x1 8.33406
78b.b24x4 6.454116
79b.b24x6 6.626254118
80b.l24x2 4.04586
81b.l24x3 4.56375405
82b.b25x3 7.30254115
83b.l25x3 7.7775129
84b.b26x3 4.77506
85b.b27x3 5.351254128
86b.l27x1 10.2307719
87b.l27x2 6.0565129
88b.b28x3 3.397557
89b.b28x6 7.6935129
90G.S1.02 6.30254135
91G.H1.01 5.6365249
92G.S2.08 5.0525134
93G.S3.03 6.515836136
94G.S3.04 7.546517
95G.S3.06 7.696519
96G.s3h2.03 5.269519
97G.H2.02 4.41625419
98G.H2.03 8.88125419
99G.H2.04 4.333754238
100G.H2.06 6.04833619
101G.H2.07 4.9618
102G.H2.09 5.65625417
103G.h2s4.01 6.847517
104G.S4.03 4.31875409
105G.S4.06 4.085438
106G.s4h3.04 5.3675609
107G.H3.09 6.58643735
108G.H3.15 4.115414
109G.H3.17 7.16333619
110G.H3.18 5.68625413
111G.S5.03 3.145509
112G.S5.04 3.91639
113G.S5.05 3.255178
114G.S5.06 5.5075439
115G.S5.07 3.3525179
116G.HG.04 5.435535
117G.hgh4.01 4.803754157
118G.hgh4.02 8.76754155
119G.hgh4.05 7.21375403
120G.H4.03 6.77634
121G.H4.10 9.246254157
122G.H4.15 5.77533
123G.h4s6.02 5.24625435
124G.h4s6.12 6.868754145
125G.S6.01 5.025437
126G.S6.02 7.621676145
127G.S6.05 5.11625439
128G.s6h5.01 4.60254177
129G.s6h5.02 2.85875409
130G.H5.03 5.366177
131G.H5.08 5.21756134
132G.H5.19 4.98754189
133G.H5.26 6.2855145
1341x32 3.70875403
1351x36 4.7225405
1361x39 3.88408
1371x40 2.17406
1381x43 6.671254277
1391x50 3.962509
1402x39 2.925407
1412x43 6.444298
1422x45 4.63875409
1432x46 3.711254289
1442x50 5.2354289
1452x51 3.6225407
1462x54 3.047506
1472x57 3.5454278
148E1 2.58375404
149E1x50 3.145509
1503x30 4.143526
1513x31 3.57375405
1523x32 5.774507
1533x33 8.73625425
1543x37 5.272528
1553x38 6.135407
1563x41 3.951505
1573x42 5.605408
1583x49 5.28375408
1593x50 4.996254269
160I2x52 6.9975405
161I2x53 6.313754185
1624x56 6.385424
163E2 11.33621323
1645x40 10.144525
1655x43 4.38875425
1665x461 6.205426
1675x58 5.859287268
168I3 6.7715143
1696x37 3.79125407
1706x45 5.93875409
1716x51 4.90357727
1726x55 6.442526
173E3 5.39062822
1747x34 7.00875425
1758x50 2.6275407
1768x54 2.44406
177g.l1x4 4.8225408
178g.ctx3 6.1415199
179g.ctx5 3.8655199
180g.ctx6 2.635486
181g.ctx14 6.61375459
182g.ctx16 5.36143758
183Lig 7.076921320
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.1x19 b.b21x2 28.44064.67NoNo066
2b.b21x2 g.h2x1 29.45865.73NoNo068
3b.b21x4 g.h2x1 29.96722.98YesNo058
4b.b20x5 b.b21x4 16.21843.46NoYes075
5b.b20x5 b.b21x7 16.22886.445NoYes075
6b.b21x7 b.b24x6 27.16868.68YesYes058
7b.b23x6 b.b24x6 27.46665.305YesYes1178
8b.b23x6 b.l21x7 30.95813.36YesNo1175
9b.l21x7 b.l23x1 32.23513.11NoYes056
10b.l23x1 b.l25x6 47.353920.845YesNo068
11b.b14x1 b.l9x6 47.77643.59YesYes188
12b.b10x1 b.b14x1 47.37733.83NoYes098
13b.b10x1 b.b11x5 47.16074.075NoNo096
14b.b11x5 b.l13x7 11.16234.845NoNo069
15b.l13x3 b.l13x7 10.91744.84YesNo099
16G.H2.07 b.l9x6 47.66663.86YesYes188
17b.1x19 b.b21x1 25.89078.935NoYes067
18b.b14x5 b.b15x1 20.83793.655NoYes059
19b.b10x4 b.b14x5 21.44876.68NoNo065
20b.b10x4 b.b2x4 21.340312.415NoNo066
21b.b2x4 b.b6x5 21.27132.725NoYes066
22b.b3x1 b.b6x5 23.81738.79YesYes756
23b.b3x1 b.b4x7 32.58742.715YesYes758
24b.b4x7 b.l2x5 24.563911.91YesNo085
25b.l2x5 b.l4x2 24.473826.235NoNo054
26b.l4x2 g.ctx15 23.60388.34NoNo049
27b.l26x5 g.ctx15 35.84919.225NoNo059
28b.l26x5 g.ctx4 40.12567.545NoNo057
29g.ctx3 g.ctx4 40.41574.83YesNo097
30b.l22x1 g.ctx3 10.26417.36NoYes1999
31b.b23x1 b.l22x1 10.44973YesNo1959
32b.b23x1 b.lhb1x9 22.33414.28YesYes053
33b.lhb1x6 b.lhb1x9 37.45743.07YesYes033
34b.l22x5 b.lhb1x6 20.41576.535YesYes893
35b.l22x5 b.l24x2 10.33346.075YesYes896
36g.ctx3 g.ctx5 31.07144.75YesYes1999
37b.b23x1 g.ctx5 10.35532.765YesYes1959
38b.lhb1x11 g.ctx5 11.52932.83NoYes049
39b.lhb1x11 b.lhb1x9 16.97072.92NoYes043
40b.h2x1 b.h2x5 29.26142.95YesYes055
41b.b24x7 b.lhb1x6 10.34788.76NoYes893
42b.l25x5 b.l27x1 11.11256.78NoYes079
43b.l25x5 b.l27x2 10.70982.69NoYes079
44g.ctx14 g.ctx15 12.75095.705YesNo099
45b.b4x7 b.b5x2 15.01252.695YesYes787
46G.HN.40 b.b5x2 11.43245.215NoYes077
47G.HN.40 b.b5x3 11.03546.885NoYes079
48G.H2.07 G.h2s4.01 46.04244.51YesYes187
49b.b6x5 b.l8x1 13.27173.515YesNo765
50b.l8x1 b.l8x8 12.93642.98NoNo054
51b.b5x7 b.l8x8 20.784511.52YesNo074
52b.b5x7 b.b8x4 16.59196.65YesYes076
53b.b7x4 b.b8x4 10.36335.38NoYes2286
54b.b12x7 b.b13x4 16.63295.06NoNo094
55b.b12x7 b.l10x4 15.66726.73NoNo093
56b.l10x4 b.l12x1 15.02585.66NoNo036
57b.b14x3 b.b15x1 19.38526.7YesYes659
58b.b11x3 b.b12x5 16.14553.725YesNo656
59b.b17x7 b.b21x1 17.62987.76YesYes487
60b.b17x7 b.b20x6 10.378910.715YesYes486
61b.b22x1 b.l23x1 16.18284.335NoYes086
62b.b22x1 b.b22x2 15.96754NoNo088
63b.b22x2 b.b26x3 15.76516.76NoYes086
64b.b27x1 g.ctx5 10.15953.725NoYes069
65b.b23x3 b.b26x3 12.942.765NoYes076
666x30 G.H5.26 90.575413.895NoYes1455
676x30 G.h4s6.12 90.90092.325NoYes1455
68G.S6.02 G.h4s6.12 90.698115.715YesYes1455
69G.H5.06 G.S6.02 88.0494.13NoYes085
70G.H5.06 G.S6.04 84.992914.705NoNo084
71G.H5.03 G.S6.04 84.55353.825YesNo1774
72G.H5.03 G.s6h5.05 95.39334.71YesNo079
73G.s6h5.04 G.s6h5.05 95.49125.06NoNo099
74G.s6h5.02 G.s6h5.04 95.58883.38YesNo099
75G.HG.01 G.s6h5.02 95.83094.04NoYes099
76G.H4.03 G.HG.01 95.92616.57YesNo049
77G.H4.03 G.S6.05 93.87565.675YesYes349
78G.S5.06 G.S6.05 48.0857.92YesYes399
79G.S5.04 G.S5.06 48.74434.845YesYes399
80G.H3.09 G.S5.04 48.28033.045YesYes359
81G.H3.09 G.S5.02 54.13025.025YesNo358
82G.S4.02 G.S5.02 1005.15NoNo078
83G.S1.05 G.S4.02 49.18192.855NoNo097
84G.S1.05 G.h2s4.01 49.09449.74NoYes097
856x37 G.H5.25 18.88146.23YesNo075
866x33 6x37 83.70963.64NoYes077
876x33 G.H5.26 83.98266.95NoYes075
88G.H4.12 G.S6.05 46.05124.1NoYes039
89G.H4.12 G.H4.16 45.97084.46NoNo034
90G.H4.16 G.S6.01 45.97622.735NoYes047
91G.S5.02 G.S6.01 45.96645.89NoYes387
92G.S4.03 G.S5.03 11.97022.945YesYes099
93G.H3.18 G.S4.02 51.53084.395YesNo037
94G.H3.15 G.H3.18 50.97483.62YesYes143
953x50 G.H5.23 12.31362.785YesNo098
963x50 G.H5.25 12.578.5YesNo2695
973x32 3x36 52.30073.14YesNo078
983x36 6x48 52.64513.14NoNo089
996x48 7x45 55.1419.06NoNo099
1006x47 7x45 67.17346.3NoNo089
1016x44 6x47 67.33823.145NoNo078
1026x44 7x52 72.2813.59NoNo078
1037x52 7x55 72.60172.62NoNo087
1046x37 7x55 72.76163.045YesNo077
1057x45 7x49 12.102312.79NoNo099
106E1 E1x50 13.30174.48YesYes049
107E1 E2x52 18.95832.825YesNo045
108E2 E2x52 12.00976.965YesNo235
109E2 Lig 12.15144.91YesYes230
1103x33 Lig 16.939817.735YesYes250
1113x33 7x38 23.39285.025YesNo255
1123x32 7x38 45.55743.135YesNo075
1137x34 Lig 11.58029.135YesYes250
1146x51 Lig 17.18926.13YesYes270
1156x51 7x38 21.98693.605YesNo275
116b.b21x4 b.h2x1 19.40682.765YesYes055
117b.h2x5 b.l24x2 10.46573.685YesYes856
118G.H3.17 b.l25x6 40.51536YesNo198
119b.b11x5 b.b14x3 35.8474.505NoYes065
120b.b11x3 b.b14x3 16.07834.47YesYes655
121b.b12x5 b.b13x4 15.61373.685NoNo664
122G.H3.15 G.H3.17 50.65715.085YesYes149
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x336x516.512YesYes5711
3x337x385.0252YesNo5512
3x33Lig17.7352YesYes5010
3x375x434.7252YesYes8521
3x375x4619.9652YesYes8622
3x376x515.462YesYes8721
3x376x523.4852YesNo8822
3x376x552.7252YesYes8621
4x565x435.2152YesYes4521
4x565x4616.432YesYes4622
4x60Lig11.840NoYes5010
4x614x622.632NoNo4422
4x61E24.252NoYes4321
4x62E22.832NoYes4321
4x63Lig2.6650NoYes4010
4x64E226.7952NoYes5311
4x64Lig11.4352NoYes5010
4x65E222.332NoYes5321
E2E228.922YesYes3311
5x32E213.752NoYes1321
E2E2x526.9652YesNo3512
E2Lig4.912YesYes3010
E2E2x512.842YesNo3412
7x34E2x522.912YesNo5512
5x35Lig3.20NoYes3010
5x365x372.8752NoNo4212
5x365x409.3452NoYes4511
5x36Lig4.2652NoYes4010
5x39Lig2.6650NoYes4010
5x406x5514.672YesYes5611
5x40E34.7952YesYes5212
5x407x3411.732YesYes5511
5x40Lig10.182YesYes5010
5x435x4614.1952YesYes5612
5x43Lig3.422YesYes5010
5x446x554.4050NoYes6621
6x516x524.072YesNo7812
6x516x555.992YesYes7611
6x517x383.6052YesNo7512
6x51Lig6.132YesYes7010
E3E33.562YesYes2222
7x34E34.262YesYes5212
7x34Lig9.1352YesYes5010
3x33E2x515.6752YesNo5412
4x645x327.012NoNo5112
6x55Lig4.422YesYes6010
6x517x372.562YesNo7712
3x26E22.3450NoYes7321
5x33E21.830NoYes1321
4x634x671.480NoNo4512
4x594x630.770NoNo7421
4x664x670.6852NoNo2522
4x66E20.6852NoYes2321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
100.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
70.59Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
58.82Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
57.14Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.85Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
53.85Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
53.85Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
52.94Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
50.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
50.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
47.37Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
47.06Single4NTJAZD12834NTJ-P2Y12-AZD1283
46.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
44.44Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
44.44Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
44.44Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
43.75Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
42.86Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
42.11Single4PY02MeSATP4PY0-P2Y12-2MeSATP
42.11Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
41.18Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
40.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
40.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
40.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
40.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
38.89Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
38.10Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
38.10Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
38.10Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
38.10Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
37.50Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
36.84Single6J21Aprepitant6J21-NK1-Aprepitant
36.84Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
36.84Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
36.84Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
36.84Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
36.84Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
36.84Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
36.84Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
36.36Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
36.36Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
36.36Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
35.29Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
35.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
35.29Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
35.29Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
35.29Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
35.29Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
35.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
35.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
35.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
35.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
35.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
34.78Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
34.62Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
33.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
33.33Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
33.33Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
33.33Single9IYAONO-97105319IYA-GPR55-ONO-9710531
33.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Consensusa3_onOrthosteric Liganda3a_on
33.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
33.33Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
33.33Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
33.33Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
33.33Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
32.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
31.82Single3NY9ICI118-5513NY9-β2-ICI118-551
31.82Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
31.82Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
31.82Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
31.82Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
31.58Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
31.58Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
31.58Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
31.58Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
31.58Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
31.58Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
31.58Single8QOTNanobody-E8QOT-μ-Nanobody-E
31.58Consensusa3_on_gpOrthosteric Liganda3a_on_gp
31.58Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.25Single6HLLCP999946HLL-NK1-CP99994
31.25Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
31.25Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
31.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
31.25Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
31.25Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
31.25Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
31.25Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.25Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
30.77Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
30.43Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
30.43Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.43Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
30.43Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
30.43Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
30.43Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
30.43Single8IEBA1LYA8IEB-GPR156-A1LYA
30.43Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
30.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
30.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
30.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
30.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
30.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
30.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
30.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
30.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
30.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
30.00Consensusa2_onOrthosteric Liganda2b_on
30.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensuslpa_onOrthosteric Ligandlpa1_on
30.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
30.00Consensustachykinin_offOrthosteric Ligandnk1_off
29.41Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
29.41Single3PWHZM-2413853PWH-A2A-ZM-241385
29.41Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
29.41Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
29.41Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
29.41Single6ME9Ramelteon6ME9-MT2-Ramelteon
29.41Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
29.41Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
29.41Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
29.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
29.41Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
29.41Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
29.41Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
29.41Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
29.41Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
29.17Single6HLOAprepitant6HLO-NK1-Aprepitant
29.17Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
29.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
28.57Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
28.57Single4RWADIPP-NH24RWA-δ-DIPP-NH2
28.57Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
28.57Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
28.57Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.57Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
28.57Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
28.57Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
28.57Single7YITNalfurafine7YIT-κ-Nalfurafine
28.57Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
28.57Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
28.57Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.57Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.57Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.57Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
28.57Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
28.57Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
28.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
28.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
27.78Single4MBSMaraviroc4MBS-CCR5-Maraviroc
27.78Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
27.78Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
27.78Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.78Single5IUBQ274563445IUB-A2A-Q27456344-Na
27.78Single5JTBZM-2413855JTB-A2A-ZM-241385
27.78Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
27.78Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
27.78Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
27.78Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
27.78Single5UVIZM-2413855UVI-A2A-ZM-241385
27.78Single6AQFZM-2413856AQF-A2A-ZM-241385
27.78Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.78Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
27.78Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
27.78Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.78Single7AROLUF58337ARO-A2A-LUF5833-Na
27.78Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
27.78Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
27.78Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
27.78Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
27.78Single7VV6C48/807VV6-MRGPRX2-C48/80
27.78Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
27.78Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
27.78Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
27.78Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
27.78Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
27.78Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
27.78Single9BJKNaloxone9BJK-μ-Naloxone-NAM
27.78Consensusa2_offOrthosteric Liganda2a_off
27.78Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
27.27Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
27.27Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
27.27Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
27.27Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
27.27Single7UM4AS26747237UM4-5-HT5A-AS2674723
27.27Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
27.27Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
27.27Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
27.27Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
27.27Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
27.27Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
27.27Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.92Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
26.92Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
26.92Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
26.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.32Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.32Single3EMLZM-2413853EML-A2A-ZM-241385
26.32Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.32Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
26.32Single4EJ4Naltrindole4EJ4-δ-Naltrindole
26.32Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
26.32Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
26.32Single5IU8Q274563475IU8-A2A-Q27456347-Na
26.32Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
26.32Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
26.32Single5UENDU1725UEN-A1-DU172
26.32Single5UIGCmpd-15UIG-A2A-Cmpd-1
26.32Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
26.32Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
26.32Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
26.32Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
26.32Single6S0LZM-2413856S0L-A2A-ZM-241385
26.32Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
26.32Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
26.32Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
26.32Single7PYRPSB-21157PYR-A2A-PSB-2115
26.32Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
26.32Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
26.32Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
26.32Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
26.32Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
26.32Single8CU6LJ-45178CU6-A2A-LJ-4517
26.32Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.32Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
26.32Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
26.32Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.32Single9CHXS-Carazolol9CHX-β2-S-Carazolol
26.32Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
26.32Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
26.32Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
26.32Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
26.32Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
26.09Single4UG2CGS216804UG2-A2A-CGS21680
26.09Single5ZTYAM102575ZTY-CB2-AM10257
26.09Single6PT3DPI-2876PT3-δ-DPI-287
26.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single7XN9L-054,5227XN9-SST2-L-054,522
26.09Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
26.09Single8IEIA1LYA8IEI-GPR156-A1LYA
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8QJ2pN1628QJ2-MC4-pN162-Gs
26.09Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
26.09Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
26.09Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.09Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
26.09Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskisspeptin_onOrthosteric Ligandkiss1_on
25.93Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
25.93Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
25.93Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.93Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
25.93Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.81Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.81Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
25.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
25.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
25.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
25.00Single5C1MBU725C1M-μ-BU72
25.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5N2SPSB365N2S-A1-PSB36
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
25.00Single5XPRBosentan5XPR-ETB-Bosentan
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
25.00Single6HLPNetupitant6HLP-NK1-Netupitant
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
25.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
25.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
25.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
25.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
25.00Single7W41PD1762527W41-BB2-PD176252
25.00Single7WC6LSD7WC6-5-HT2A-LSD
25.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
25.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
25.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
25.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
25.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
25.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
25.00Single8IEPA1LYA8IEP-GPR156-A1LYA
25.00Single8IEPA1LYA8IEP-GPR156-A1LYA
25.00Single8JXSPF-61428JXS-D1-PF-6142
25.00Single8S4DCMF-0198S4D-Apelin-CMF-019
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
25.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
25.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8WDTphotoNECA8WDT-A2A-photoNECA
25.00Single8WKYPG-9348WKY-MC4-PG-934
25.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
25.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
25.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
25.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
25.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
25.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
25.00Consensusbombesin_offOrthosteric Ligandbb2_off
25.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
25.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
25.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
25.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
25.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
25.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
25.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
25.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
25.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
24.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
24.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
24.00Single3QAKUK-4320973QAK-A2A-UK-432097
24.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
24.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
24.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
24.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
24.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
24.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
24.00Single8IEBA1LYA8IEB-GPR156-A1LYA
24.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
24.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
24.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
24.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
24.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.81Single2YDVNECA2YDV-A2A-NECA
23.81Single3P0GBI1671073P0G-β2-BI167107
23.81Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
23.81Single4UHRCGS216804UHR-A2A-CGS21680
23.81Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.81Single5D5AS-Carazolol5D5A-β2-S-Carazolol
23.81Single5D5BS-Carazolol5D5B-β2-S-Carazolol
23.81Single5G53NECA5G53-A2A-NECA-Gs
23.81Single5TZRMK86665TZR-FFA1-MK8666
23.81Single5XR8AM8415XR8-CB1-AM841
23.81Single5XRAAM115425XRA-CB1-AM11542
23.81Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
23.81Single6E59L-7607356E59-NK1-L-760735
23.81Single6J20Aprepitant6J20-NK1-Aprepitant
23.81Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
23.81Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
23.81Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
23.81Single7FEECP559407FEE-CB1-CP55940-ZCZ011
23.81Single7PX4PSB-21137PX4-A2A-PSB-2113
23.81Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
23.81Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.81Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
23.81Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
23.81Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
23.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
23.81Single8E0GBU728E0G-μ-BU72
23.81Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
23.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
23.81Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
23.81Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.81Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
23.81Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
23.81Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
23.81Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
23.81Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
23.81Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
23.81Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
23.81Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.81Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
23.81Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
23.81Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
23.81Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single3PBLEticlopride3PBL-D3-Eticlopride
23.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
23.53Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
23.53Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
23.53Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
23.53Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
23.53Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
23.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
23.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
23.33Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.33Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.33Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.33Consensusbradykinin_onOrthosteric Ligandbk2_on
23.33Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
23.08Single6PT2KGCHM076PT2-δ-KGCHM07
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
23.08Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
23.08Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
23.08Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
23.08Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
23.08Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.08Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.08Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
22.73Single3D4STimolol3D4S-β2-Timolol
22.73Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
22.73Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
22.73Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
22.73Single6KQICP559406KQI-CB1-CP55940-Org27569
22.73Single6MXTSalmeterol6MXT-β2-Salmeterol
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
22.73Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.73Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
22.73Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.73Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
22.73Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
22.73Single8JJ8Formoterol8JJ8-β2-Formoterol
22.73Single8JJLOlodaterol8JJL-β2-Olodaterol
22.73Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
22.73Single8JWY2-1188JWY-A2A-2-118
22.73Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
22.73Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
22.73Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.73Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
22.73Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
22.73Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
22.73Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.73Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
22.73Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
22.73Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
22.73Consensuslpl_offOrthosteric Ligands1p_off lpa_off
22.58Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
22.58Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.58Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.58Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
22.58Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
22.22Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
22.22Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
22.22Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
22.22Single6AKXA4R6AKX-CCR5-A4R
22.22Single6AKYMaraviroc6AKY-CCR5-Maraviroc
22.22Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
22.22Single6DS0Ly2660976DS0-5-HT2B-Ly266097
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
22.22Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
22.22Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.22Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
22.22Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
22.22Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
22.22Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.22Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
22.22Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
22.22Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
22.22Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
22.22Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
22.22Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
22.22Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
22.22Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.22Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
22.22Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
22.22Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
22.22Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
22.22Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
22.22Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.22Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.22Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
22.22Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.22Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
22.22Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensusvasop-oxy_onOrthosteric Ligandv2_on
22.22Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
21.88Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.74Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.74Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
21.74Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
21.74Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
21.74Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
21.74Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
21.74Single7EZCUKA7EZC-A2A-UKA
21.74Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
21.74Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
21.74Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
21.74Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
21.74Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
21.74Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
21.74Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
21.74Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
21.74Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.74Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
21.74Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
21.74Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.74Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
21.74Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.74Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.43Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
21.43Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
21.43Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.43Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.43Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
21.43Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.43Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.43Single8ZRTET-18ZRT-ETB-ET-1
21.43Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.43Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.43Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single3REYXAC3REY-A2A-XAC
21.05Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
21.05Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
21.05Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
21.05Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.05Single6PS0S-Carazolol6PS0-β2-S-Carazolol
21.05Single6PS4ICI118-5516PS4-β2-ICI118-551
21.05Single6PS5S-Propranolol6PS5-β2-S-Propranolol
21.05Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
21.05Single6TPNHTL66416TPN-OX2-HTL6641
21.05Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
21.05Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
21.05Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
21.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
21.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
21.05Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
21.05Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single7T32ZM-2413857T32-A2A-ZM-241385
21.05Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
21.05Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
21.05Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
21.05Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
21.05Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
21.05Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
21.05Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
21.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
21.05Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
21.05Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
21.05Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
21.05Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.05Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
21.05Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
21.05Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
21.05Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
21.05Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
21.05Consensusalpha1_onOrthosteric Ligandalpha1a_on
21.05Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
21.05Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
21.05Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
21.05Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.05Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
21.05Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.83Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.83Single5WF6UK-4320975WF6-A2A-UK-432097
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.83Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.83Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.83Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
20.83Single8XQJJN2418XQJ-Apelin-JN241
20.83Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.83Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.83Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.83Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
20.83Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
20.83Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.83Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.69Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.69Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.69Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
20.69Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.69Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.69Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
20.00Single2Y02Carmoterol2Y02-β1-Carmoterol
20.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.00Single3NY8ICI118-5513NY8-β2-ICI118-551
20.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
20.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
20.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
20.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
20.00Single6PS1Timolol6PS1-β2-Timolol
20.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.00Single7BU7BI1671077BU7-β1-BI167107
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
20.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
20.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
20.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
20.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
20.00Single7V3ZCP559407V3Z-CB1-CP55940
20.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
20.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
20.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
20.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
20.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
20.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
20.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
20.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
20.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Single8IEIA1LYA8IEI-GPR156-A1LYA
20.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
20.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
20.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
20.00Single8JXRLSD8JXR-D1-LSD
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
20.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8RLNLUF58348RLN-A2A-LUF5834
20.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
20.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
20.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
20.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
20.00Single8X64Desloratadine8X64-H1-Desloratadine
20.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
20.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
20.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
20.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
20.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
20.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
20.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
20.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
20.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
20.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
20.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
20.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
20.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
20.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
20.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
20.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
20.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
20.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.44Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.44Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.35Single6IGLIRL16206IGL-ETB-IRL1620
19.35Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
19.35Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
19.35Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
19.23Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
19.23Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
19.23Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
19.23Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
19.23Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
19.23Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
19.23Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
19.23Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
19.05Single2RH1S-Carazolol2RH1-β2-S-Carazolol
19.05Single5JQHS-Carazolol5JQH-β2-S-Carazolol
19.05Single5N2RPSB-365N2R-A2A-PSB-36-Na
19.05Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
19.05Single6E67BI1671076E67-β2-BI167107-Gs (fused)
19.05Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
19.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
19.05Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
19.05Single6PS6Timolol6PS6-β2-Timolol
19.05Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
19.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
19.05Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
19.05Single7C61Ergotamine7C61-5-HT1B-Ergotamine
19.05Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
19.05Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
19.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
19.05Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
19.05Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
19.05Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
19.05Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
19.05Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
19.05Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
19.05Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
19.05Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
19.05Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
19.05Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
19.05Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
19.05Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
19.05Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.05Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
19.05Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.05Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
19.05Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
19.05Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
19.05Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
19.05Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
19.05Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
19.05Consensusamine_offonOrthosteric Ligandamine_off amine_on
19.05Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
19.05Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
19.05Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
19.05Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
19.05Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.05Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.05Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
19.05Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
19.05Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.05Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
19.05Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
19.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.05Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.05Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Consensustrace-amine_onOrthosteric Ligandta1_on
18.75Single5GLHEndothelin-15GLH-ETB-Endothelin-1
18.75Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.75Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.75Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
18.75Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.75Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.75Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.52Single3OE0CVX153OE0-CXCR4-CVX15
18.52Single5WF5UK-4320975WF5-A2A-UK-432097
18.52Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
18.52Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
18.52Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
18.52Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.52Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
18.52Consensusangiotensin_onOrthosteric Ligandat1_on
18.52Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
18.52Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
18.52Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
18.52Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
18.18Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
18.18Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
18.18Single5V54Methiothepin5V54-5-HT1B-Methiothepin
18.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.18Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.18Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
18.18Single6WGTLSD6WGT-5-HT2A-LSD
18.18Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
18.18Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
18.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
18.18Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
18.18Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
18.18Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
18.18Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
18.18Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
18.18Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
18.18Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
18.18Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.18Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
18.18Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
18.18Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
18.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
18.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.18Single8XVLZibotentan8XVL-ETA-Zibotentan
18.18Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.18Consensus5ht1_offOrthosteric Ligand5ht1b_off
18.18Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
18.18Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
18.18Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
18.18Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
18.18Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
18.18Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.18Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
18.18Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.18Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
18.18Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
18.18Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
18.18Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.86Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.86Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.86Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.86Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
17.86Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
17.86Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
17.86Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
17.86Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.86Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.86Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
17.86Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.65Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
17.65Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
17.65Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
17.65Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
17.65Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
17.65Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
17.65Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
17.65Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.65Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.65Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.65Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.65Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.65Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.65Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
17.65Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.65Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.65Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.65Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.39Single4AMIBucindolol4AMI-β1-Bucindolol
17.39Single4LDEBI1671074LDE-β2-BI167107
17.39Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.39Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
17.39Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
17.39Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
17.39Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
17.39Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
17.39Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
17.39Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
17.39Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
17.39Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.39Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
17.39Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
17.39Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
17.39Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
17.39Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.39Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
17.39Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.39Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.39Single8JWZAB9288JWZ-A2A-AB928-Na
17.39Single8XQJJN2418XQJ-Apelin-JN241
17.39Single8XWACXCL18XWA-CXCR2-CXCL1
17.39Single8XWMCXCL68XWM-CXCR2-CXCL6
17.39Single8XWSCXCL58XWS-CXCR2-CXCL5
17.39Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
17.39Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
17.39Consensusalpha1_offOrthosteric Ligandalpha1a_off
17.39Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
17.39Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.39Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.39Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
17.39Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
17.39Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.39Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
17.39Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.39Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
17.39Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
17.39Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
17.39Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.39Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.39Consensusorexin_onOrthosteric Ligandox2_on
17.39Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
17.39Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
17.24Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
17.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.24Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
17.24Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.14Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5X93K-87945X93-ETB-K-8794
16.67Single6H7LDobutamine6H7L-β1-Dobutamine
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6IBLArformoterol6IBL-β1-Arformoterol
16.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
16.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
16.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
16.67Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
16.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
16.67Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
16.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
16.67Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8XVUCXCL28XVU-CXCR2-CXCL2
16.67Single8XWFCXCL38XWF-CXCR2-CXCL3
16.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
16.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
16.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
16.67Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Consensuschemerin_onOrthosteric Ligandcml1_on
16.67Consensusendothelin_offOrthosteric Ligandetb_off
16.67Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
16.67Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
16.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
16.13Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.00Single6KNMJN241-96KNM-Apelin-JN241-9
16.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
16.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
16.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
16.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
16.00Single8X5YAstemizole8X5Y-H1-Astemizole
16.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
16.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.79Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.79Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.79Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.79Single5WS3EMPA5WS3-OX2-EMPA
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6B73MP11046B73-κ-MP1104
15.79Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
15.79Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.79Single6TODEMPA6TOD-OX1-EMPA-Na
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
15.79Single7F8ULintitript7F8U-CCKA-Lintitript
15.79Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
15.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.79Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
15.79Single7XRRLemborexant7XRR-OX2-Lemborexant
15.79Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
15.79Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
15.79Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
15.79Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
15.79Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
15.79Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
15.79Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
15.79Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
15.79Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.79Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
15.79Consensusalpha2_offOrthosteric Ligandalpha2c_off
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusorexin_offOrthosteric Ligandox2_off ox1_off
15.79Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
15.79Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.79Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.79Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
15.79Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
15.38Single7F8XNN90567F8X-CCKA-NN9056
15.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
15.38Single7QA8Peptide7QA8-STE2-Peptide
15.38Single7QA8Peptide7QA8-STE2-Peptide
15.38Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
15.38Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
15.38Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.38Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.38Single8XWNCXCL88XWN-CXCR2-CXCL8
15.15Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
15.00Single2YDOAdenosine2YDO-A2A-Adenosine
15.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.00Single3RZECidoxepin3RZE-H1-Cidoxepin
15.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.00Single6A94Zotepine6A94-5-HT2A-Zotepine
15.00Single6IQLL7458706IQL-D4-L745870
15.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
15.00Single6KUXRS-799486KUX-α2a-RS-79948
15.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.00Single6TPGEMPA6TPG-OX2-EMPA
15.00Single6TPKRetosiban6TPK-OT-Retosiban
15.00Single6VI4JDTic6VI4-κ-JDTic
15.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
15.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
15.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
15.00Single7UL3Famotidine7UL3-H2-Famotidine
15.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
15.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
15.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
15.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
15.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
15.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
15.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
15.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
15.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
15.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
15.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
15.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.00Consensusgrh_offOrthosteric Ligandgnrh1_off
15.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.00Consensussensory_offOrthosteric Ligandopsins_off
15.00Consensusvasop-oxy_offOrthosteric Ligandot_off
14.81Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
14.81Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
14.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.81Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
14.81Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
14.81Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
14.81Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
14.81Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
14.29Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
14.29Single2Y01Dobutamine2Y01-β1-Dobutamine
14.29Single2Y04Salbutamol2Y04-β1-Salbutamol
14.29Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
14.29Single4QIMANTA XV4QIM-SMO-ANTA XV
14.29Single4QKX35V4QKX-β2-35V
14.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.29Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
14.29Single6H7MSalbutamol6H7M-β1-Salbutamol
14.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Single6TOTLemborexant6TOT-OX1-Lemborexant
14.29Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
14.29Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.29Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
14.29Single7UL4Alvimopan7UL4-μ-Alvimopan
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
14.29Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
14.29Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
14.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
14.29Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.29Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
14.29Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
14.29Single8JJOAlprenolol8JJO-β2-Alprenolol
14.29Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
14.29Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.29Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.29Single8T1WCVN4248T1W-GPR6-CVN424
14.29Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
14.29Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
14.29Single8X63Mepyramine8X63-H1-Mepyramine
14.29Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.29Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
14.29Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.29Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
14.29Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
14.29Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
14.29Consensusalpha2_onOrthosteric Ligandalpha2b_on
14.29Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
14.29Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.29Consensuscck_offOrthosteric Ligandccka_off
14.29Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
14.29Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Consensushistamine_offOrthosteric Ligandh1_off
14.29Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
14.29Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
13.79Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.79Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
13.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
13.79Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
13.79Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.79Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
13.79Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
13.64Single2Y00Dobutamine2Y00-β1-Dobutamine
13.64Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.64Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
13.64Single5WIUNemonapride5WIU-D4-Nemonapride
13.64Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.64Single5WQCEMPA5WQC-OX2-EMPA
13.64Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
13.64Single6D26Fevipiprant6D26-DP2-Fevipiprant
13.64Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
13.64Single6TP6Filorexant6TP6-OX1-Filorexant
13.64Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.64Single6Z4SSR486926Z4S-NTS1-SR48692
13.64Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.64Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
13.64Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
13.64Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
13.64Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
13.64Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
13.64Single8ZMFA1L108ZMF-5-HT2C-A1L10
13.64Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
13.64Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
13.64Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
13.64Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
13.64Consensusdp_offOrthosteric Liganddp2_off
13.33Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
13.33Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
13.33Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
13.33Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
13.33Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
13.04Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
13.04Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
13.04Single4BV0Neurotensin4BV0-NTS1-Neurotensin
13.04Single4DJHJDTic4DJH-κ-JDTic
13.04Single4U15Tiotropium4U15-M3-Tiotropium
13.04Single5V56TC1145V56-SMO-TC114
13.04Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.04Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
13.04Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.04Single6OL9Tiotropium6OL9-M5-Tiotropium
13.04Single6OS1TRV0266OS1-AT1-TRV026
13.04Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.04Single7B6WCyclazosin7B6W-α1b-Cyclazosin
13.04Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
13.04Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.04Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
13.04Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
13.04Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
13.04Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
13.04Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
13.04Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
13.04Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
13.04Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
13.04Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
13.04Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.04Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
13.04Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
13.04Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
13.04Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
13.04Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
13.04Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.04Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
13.04Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
13.04Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.04Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.04Consensusneurotensin_onOrthosteric Ligandnts1_on
13.04Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.04Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
13.04Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.04Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
12.90Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
12.90Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
12.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.90Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.90Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.90Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.90Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
12.82Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
12.50Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
12.50Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.50Single4N4WSANT-14N4W-SMO-SANT-1
12.50Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.50Single4XESNeurotensin4XES-NTS1-Neurotensin
12.50Single5CXVTiotropium5CXV-M1-Tiotropium
12.50Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
12.50Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
12.50Single6A93Risperidone6A93-5-HT2A-Risperidone
12.50Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
12.50Single6CM4Risperidone6CM4-D2-Risperidone
12.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
12.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.50Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
12.50Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
12.50Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
12.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.50Single7WC4Serotonin7WC4-5-HT2A-Serotonin
12.50Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
12.50Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
12.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
12.50Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
12.50Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
12.50Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
12.50Single8XYIVUF106618XYI-CXCR3-VUF10661
12.50Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.50Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.50Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
12.50Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.12Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.12Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.12Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
12.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
12.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.00Single6K1QIRL25006K1Q-ETB-IRL2500
12.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
12.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
12.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
12.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
12.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
12.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
12.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
11.76Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.76Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
11.76Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single9CHUNoradrenaline9CHU-β2-Noradrenaline
11.76Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
11.76Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
11.76Consensusbombesin_onOrthosteric Ligandbb2_on
11.76Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
11.76Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
11.76Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.76Consensusp2y_offOrthosteric Ligandp2y1_off
11.76Consensussensory_onOrthosteric Ligandopsins_on
11.54Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
11.54Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
11.54Single7SK9CCX6627SK9-ACKR3-CCX662
11.54Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.54Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
11.43Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
11.11Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.11Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single4XT1Fractalkine4XT1-US28-Fractalkine
11.11Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.11Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
11.11Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.11Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
11.11Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
11.11Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.11Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
11.11Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.11Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
11.11Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.11Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Consensusgi_sensoryOrthosteric Ligandgi_opsins
11.11Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.11Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.11Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.11Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.11Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.71Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
10.71Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
10.71Single7XNACYN1548067XNA-SST2-CYN154806
10.71Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.71Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.53Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.53Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.53Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.53Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.53Single7UL2SR486927UL2-NTS1-SR48692-Na
10.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
10.53Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.53Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.53Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.53Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
10.53Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.53Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
10.53Single9B9Y7DY9B9Y-CB1-7DY
10.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
10.53Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Consensusneurotensin_offOrthosteric Ligandnts1_off
10.53Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
10.34Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
10.34Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
10.34Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.34Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
10.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
10.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
10.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
10.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
10.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
10.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
10.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
10.00Single8IWESpermidine8IWE-TA9-Spermidine
10.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
10.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
10.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
10.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
10.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
10.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.68Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
9.68Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
9.68Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
9.68Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
9.68Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
9.68Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
9.68Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
9.68Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
9.68Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
9.52Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
9.52Single6TP3Nemorexant6TP3-OX1-Nemorexant
9.52Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.52Single6V9SGTPL114036V9S-OX1-GTPL11403
9.52Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.52Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.52Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
9.52Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
9.52Single8IYXYL-3658IYX-GPR34-YL-365
9.52Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
9.52Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
9.52Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
9.52Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
9.52Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.52Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
9.52Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
9.52Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
9.52Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
9.38Single4XT3Fractalkine4XT3-US28-Fractalkine
9.38Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
9.38Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
9.38Single7SK3CXCL127SK3-ACKR3-CXCL12
9.38Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
9.38Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
9.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.38Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
9.38Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.38Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
9.09Single4DAJTiotropium4DAJ-M3-Tiotropium
9.09Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
9.09Single4MQSIperoxo4MQS-M2-Iperoxo
9.09Single4U14Tiotropium4U14-M3-Tiotropium
9.09Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
9.09Single5DHGC-355DHG-NOP-C-35
9.09Single5DHHSB-6121115DHH-NOP-SB-612111
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
9.09Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
9.09Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
9.09Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
9.09Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
9.09Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.09Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
9.09Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
9.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.09Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
9.09Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.09Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
9.09Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.09Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.09Consensusblt_onOrthosteric Ligandblt1_on
9.09Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
9.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
9.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
9.09Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.09Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.09Consensusleukotriene_onOrthosteric Ligandblt_on
9.09Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.09Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
9.09Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
8.82Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
8.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
8.82Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
8.82Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
8.82Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
8.82Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
8.82Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
8.82Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
8.82Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
8.70Single4JKVTaladegib4JKV-SMO-Taladegib
8.70Single6LUQHaloperidol6LUQ-D2-Haloperidol
8.70Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.70Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.70Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.70Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.70Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
8.70Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
8.70Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
8.70Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.70Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
8.70Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
8.70Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.70Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.70Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.70Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
8.70Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
8.57Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
8.33Single5V57TC1145V57-SMO-TC114
8.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
8.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8EA0Iperoxo8EA0-M3-Iperoxo
8.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
8.33Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
8.33Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
8.33Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
8.33Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.11Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
8.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
8.11Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
8.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.11Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single6OS2TRV0266OS2-AT1-TRV026
8.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
8.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
8.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
8.00Single7DFPSpiperone7DFP-D2-Spiperone
8.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
8.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
8.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
8.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
8.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
8.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
8.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.89Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
7.89Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
7.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
7.89Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.69Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
7.69Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
7.69Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
7.69Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
7.69Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
7.69Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single5EE7MK08935EE7-Glucagon-MK0893
7.41Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
7.41Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.41Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.41Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
7.14Consensussomatostatin_offOrthosteric Ligandsst2_off
6.90Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
6.90Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
6.90Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.67Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.67Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.45Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
6.45Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
6.45Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
6.25Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
6.25Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.25Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single6FJ3PTH6FJ3-PTH1-PTH
6.06Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.06Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.06Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
6.06Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
6.06Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
5.88Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
5.88Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.88Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
5.88Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.88Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.88Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.71Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
5.71Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
5.71Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
5.71Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
5.71Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.71Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
5.56Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.56Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
5.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
5.56Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.56Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
5.56Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.41Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.26Single3OE6IT1t3OE6-CXCR4-IT1t
5.26Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.26Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
5.26Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.13Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
5.13Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.00Single3OE9IT1t3OE9-CXCR4-IT1t
5.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.00Single5L7IVismodegib5L7I-SMO-Vismodegib
5.00Single5NDZAZ3451; Na5NDZ-PAR2-AZ3451; Na
5.00Single6LI0C176LI0-GPR52-C17
5.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
5.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
5.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
5.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
5.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.00Single8K5BNiacin8K5B-HCA2-Niacin
5.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
5.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
5.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
5.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.76Single3ODUIT1t3ODU-CXCR4-IT1t
4.76Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
4.76Single4QINSAG1.54QIN-SMO-SAG1.5
4.76Single5U09Taranabant5U09-CB1-Taranabant
4.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.76Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
4.76Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
4.76Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
4.76Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
4.76Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
4.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
4.76Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
4.76Single8Y0HVUF114188Y0H-CXCR3-VUF11418
4.76Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76Single9BA0A1AKN9BA0-CB1-A1AKN
4.76Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
4.76Consensusangiotensin_offOrthosteric Ligandat1_off
4.76Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.76Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
4.76Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.55Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.55Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.55Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.55Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
4.55Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.55Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.55Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.55Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.55Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
4.55Single8IHKAcifran8IHK-HCA3-Acifran
4.55Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
4.55Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
4.55Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
4.55Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
4.55Single8K2WAMG4878K2W-CXCR3-AMG487
4.55Single8K5CAcipimox8K5C-HCA2-Acipimox
4.55Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
4.55Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
4.55Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
4.55Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.55Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
4.55Consensushca_onOrthosteric Ligandhca2_on
4.55Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.35Single4YAYZD-71554YAY-AT1-ZD-7155
4.35Single5T04Neurotensin5T04-NTS1-Neurotensin
4.35Single6FFHFenobam6FFH-mGlu5-Fenobam
4.35Single6GPSMK08126GPS-CCR2-MK0812
4.35Single6IIVDaltroban6IIV-TP-Daltroban
4.35Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.35Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.35Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.35Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.35Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
4.35Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
4.35Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
4.35Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
4.35Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.35Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
4.35Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.35Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
4.35Single9B9ZA1AKO9B9Z-CB1-A1AKO
4.35Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.35Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.35Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
4.35Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.35Consensushca_on_gpOrthosteric Ligandhca2_on_gp
4.17Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
4.17Single5CGCHTL142425CGC-mGlu5-HTL14242
4.17Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
4.17Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
4.17Single6GPXMK08126GPX-CCR2-MK0812
4.17Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.17Single7C4SS1P7C4S-S1P3-S1P
4.17Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
4.17Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
4.17Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
4.17Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
4.17Consensusep_offOrthosteric Ligandep4_off
4.17Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
4.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.00Single7P2L4YI7P2L-mGlu5-4YI
4.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
4.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
4.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
4.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
3.85Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
3.85Single6IIURamatroban6IIU-TP-Ramatroban
3.85Single7K15MKD0467K15-BLT1-MKD046-Na
3.85Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
3.85Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
3.85Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.70Single5CGDHTL142425CGD-mGlu5-HTL14242
3.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.70Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
3.70Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.70Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
3.70Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
3.70Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.57Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
3.57Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.45Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.45Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.33Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.33Single7SHEPI; PE7SHE-GPR158-PI; PE
3.33Single7SK5CXCL127SK5-ACKR3-CXCL12
3.12Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.12Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.12Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
3.03Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.03Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
2.86Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.63Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.27Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.22Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3

Consensus Members
Id Members
ffa2_on_gp 8J22-FFA2-TUG-1375-Gi1/β1/γ2
ffa3_on_gp 8J21-FFA3-Butyric acid-Gi1/β1/γ2
Net Summary
Imin 2.625
Number of Linked Nodes 861
Number of Links 1077
Number of Hubs 183
Number of Links mediated by Hubs 678
Number of Communities 30
Number of Nodes involved in Communities 253
Number of Links involved in Communities 374
Path Summary
Number Of Nodes in MetaPath 123
Number Of Links MetaPath 122
Number of Shortest Paths 1307921
Length Of Smallest Path 3
Average Path Length 31.8856
Length of Longest Path 65
Minimum Path Strength 0.565
Average Path Strength 5.71644
Maximum Path Strength 24.5625
Minimum Path Correlation 0.7
Average Path Correlation 0.978408
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.72414
Average % Of Corr. Nodes 43.8811
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.5691
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
lipid_on_gpcannabinoid_on_gp
ffa_on_gp
lpl_on_gp
prostanoid_on_gp
leukotriene_on_gp



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Download ffa_on_gp.zip



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