Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L58 5.3325406
2R:R:D64 7.585409
3R:R:V67 4.11516
4R:R:F74 7.702516
5R:R:W83 6.59728
6R:R:F85 8.366527
7R:R:Y95 6.68833655
8R:R:C97 4.06416
9R:R:Y102 5.66407
10R:R:W106 7.31167615
11R:R:T109 4.39617
12R:R:R115 4.7975419
13R:R:R129 9.69407
14R:R:L138 5.21407
15R:R:Y155 8.3275414
16R:R:R156 16.0425415
17R:R:P170 11.955414
18R:R:Y172 10.5375414
19R:R:R178 9.96414
20R:R:H181 5.53415
21R:R:E185 5.736515
22R:R:F190 10.6025418
23R:R:P193 8.9725419
24R:R:F194 6.995416
25R:R:Y201 5.22418
26R:R:L208 2.07408
27R:R:R215 7.215405
28R:R:V223 3.7825417
29R:R:I227 3.85418
30R:R:F230 7.338519
31R:R:W234 9.33857719
32R:R:Y237 6.95833616
33R:R:H238 6.16667618
34R:R:N241 8.935416
35R:R:E244 8.055403
36R:R:R247 5.135472
37R:R:L263 4.3475
38R:R:R267 7.552514
39R:R:F275 7.1275416
40R:R:S279 2.8775407
41R:R:Y285 4.28439
42R:R:G309 2.4275407
43L:L:?1 9.062861410
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F233 R:R:L273 11.00734.87NoNo078
2R:R:F233 R:R:S277 29.52917.93NoNo079
3R:R:S277 R:R:W234 30.92457.41NoYes099
4L:L:?1 R:R:W234 40.06938.05YesYes109
5R:R:F275 R:R:L25 10.355210.96YesNo067
6R:R:L276 R:R:S279 14.9793NoYes057
7R:R:F233 R:R:L276 17.90497.31NoNo075
8R:R:S279 R:R:V31 10.54613.23YesNo075
9R:R:D64 R:R:N36 10.19656.73YesNo099
10R:R:D64 R:R:S278 58.94078.83YesNo099
11R:R:S278 R:R:V67 59.45773.23NoYes096
12R:R:F275 R:R:V67 12.37043.93YesYes166
13L:L:?1 R:R:V67 46.60853.51YesYes106
14I:I:?1 R:R:D64 49.14968.05NoYes009
15I:I:?1 R:R:S104 49.36115.94NoNo009
16R:R:F230 R:R:S104 49.92513.96YesNo099
17R:R:F230 R:R:W234 49.2721.05YesYes199
18R:R:I43 R:R:V57 10.23773.07NoNo077
19R:R:V57 R:R:Y285 52.64535.05NoYes079
20R:R:N281 R:R:Y285 55.18054.65NoYes399
21R:R:D64 R:R:N281 1006.73YesNo099
22R:R:G309 R:R:M47 44.53751.75YesNo076
23R:R:A54 R:R:M47 48.63843.22NoNo076
24R:R:A54 R:R:S51 50.68591.71NoNo077
25R:R:E314 R:R:S51 52.72178.62NoNo067
26R:R:E314 R:R:T53 56.77865.64NoNo067
27R:R:F317 R:R:T53 84.32776.49NoNo077
28R:R:F317 R:R:V57 43.78843.93NoNo077
29R:R:F317 R:R:L222 42.35197.31NoNo077
30R:R:I226 R:R:L222 43.23024.28NoNo077
31R:R:I226 R:R:N281 44.10277.08NoNo379
32R:R:F230 R:R:V105 41.51765.24YesNo198
33R:R:V105 R:R:W106 31.71473.68NoYes185
34R:R:I141 R:R:W106 19.58233.52NoYes065
35R:R:I141 R:R:L107 17.77277.14NoNo067
36R:R:L107 R:R:M56 16.00425.65NoNo077
37R:R:L138 R:R:M56 17.052.83YesNo077
38R:R:R129 R:R:T53 27.7435.17YesNo077
39R:R:F194 R:R:F230 33.51553.22YesYes169
40R:R:F194 R:R:I108 40.72743.77YesNo068
41R:R:I108 R:R:I227 33.90034.42NoYes088
42R:R:I227 R:R:V223 17.81683.07YesYes187
43L:L:?1 R:R:F74 27.957515.79YesYes106
44R:R:C93 R:R:F73 10.47275.59NoNo056
45R:R:C93 R:R:F74 35.49254.19NoYes056
46R:R:C93 R:R:W83 23.77723.92NoYes058
47L:L:?1 R:R:R156 12.29412.17YesYes105
48R:R:R156 R:R:V152 13.93033.92YesNo054
49R:R:V152 R:R:Y95 12.84923.79NoYes045
50R:R:E185 R:R:H181 11.12194.92YesYes155
51R:R:L144 R:R:W106 10.44924.56NoYes045
52R:R:T109 R:R:W106 13.11657.28YesYes175
53R:R:I108 R:R:T109 12.12663.04NoYes087
54R:R:S112 R:R:T109 16.0633.2NoYes197
55R:R:S112 R:R:S200 14.67643.26NoNo096
56R:R:I227 R:R:Y201 18.47184.84YesYes188
57R:R:R115 R:R:Y201 14.4597.2YesYes198
58R:R:R115 R:R:V223 15.27865.23YesYes197
59R:R:I204 R:R:R115 21.38893.76NoYes089
60R:R:S200 R:R:Y116 12.21762.54NoNo068
61R:R:R129 R:R:S125 19.40312.64YesNo075
62R:R:L117 R:R:S125 15.13183NoNo055
63R:R:L117 R:R:V124 12.98735.96NoNo055
64L:L:?1 R:R:P170 11.53617.74YesYes104
65R:R:P170 R:R:Y172 12.12958.34YesYes144
66R:R:H177 R:R:Y155 10.73127.62NoYes124
67R:R:R267 R:R:Y237 16.64173.09YesYes146
68R:R:E244 R:R:R267 20.601612.79YesYes034
69R:R:F190 R:R:H238 14.347412.44YesYes188
70R:R:I204 R:R:L208 17.06771.43NoYes088
71R:R:L208 R:R:R215 10.68423.64YesYes085
72R:R:E244 R:R:R247 14.63825.82YesYes032
73R:R:E311 R:R:G309 36.25331.64NoYes037
74R:R:E311 R:R:L304 32.0763.98NoNo034
75R:R:L304 R:R:V315 25.7664.47NoNo046
76R:R:L293 R:R:V315 23.65094.47NoNo076
77R:R:L293 R:R:L316 21.52992.77NoNo075
78R:R:F312 R:R:L316 19.403110.96NoNo045
79R:R:F312 R:R:L305 17.270415.83NoNo047
80R:R:L305 R:R:V301 15.13182.98NoNo073
81R:R:R294 R:R:V301 12.987317NoNo063
82L:L:?1 R:R:Y237 14.18294.84YesYes106
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L78 R:R:S18 6.01 0 No No 3 4 1 2
R:R:F275 R:R:L25 10.96 1 Yes No 6 7 1 2
R:R:C97 R:R:V67 3.42 1 Yes Yes 6 6 1 1
R:R:S100 R:R:V67 6.46 0 No Yes 8 6 2 1
R:R:F275 R:R:V67 3.93 1 Yes Yes 6 6 1 1
R:R:S278 R:R:V67 3.23 0 No Yes 9 6 2 1
L:L:?1 R:R:V67 3.51 1 Yes Yes 0 6 0 1
R:R:F74 R:R:T70 5.19 1 Yes No 6 6 1 2
R:R:C97 R:R:T70 3.38 1 Yes No 6 6 1 2
R:R:C93 R:R:F74 4.19 0 No Yes 5 6 2 1
R:R:F74 R:R:H94 9.05 1 Yes No 6 6 1 1
R:R:F275 R:R:F74 4.29 1 Yes Yes 6 6 1 1
L:L:?1 R:R:F74 15.79 1 Yes Yes 0 6 0 1
L:L:?1 R:R:L78 5.71 1 Yes No 0 3 0 1
R:R:H94 R:R:R156 29.34 1 No Yes 6 5 1 1
L:L:?1 R:R:H94 22.73 1 Yes No 0 6 0 1
L:L:?1 R:R:C97 7.48 1 Yes Yes 0 6 0 1
R:R:E185 R:R:M101 6.77 1 Yes No 5 7 2 2
R:R:M101 R:R:W234 11.63 1 No Yes 7 9 2 1
R:R:H238 R:R:M101 3.94 1 Yes No 8 7 2 2
R:R:R156 R:R:V152 3.92 1 Yes No 5 4 1 2
R:R:P170 R:R:R156 18.74 1 Yes Yes 4 5 1 1
L:L:?1 R:R:R156 12.17 1 Yes Yes 0 5 0 1
R:R:F169 R:R:P170 13 1 No Yes 3 4 1 1
L:L:?1 R:R:F169 5.02 1 Yes No 0 3 0 1
R:R:P170 R:R:Y172 8.34 1 Yes Yes 4 4 1 2
L:L:?1 R:R:P170 7.74 1 Yes Yes 0 4 0 1
R:R:E185 R:R:Y237 6.73 1 Yes Yes 5 6 2 1
R:R:E185 R:R:H238 3.69 1 Yes Yes 5 8 2 2
R:R:E185 R:R:N241 6.57 1 Yes Yes 5 6 2 2
R:R:F230 R:R:W234 21.05 1 Yes Yes 9 9 2 1
R:R:W234 R:R:Y237 6.75 1 Yes Yes 9 6 1 1
R:R:H238 R:R:W234 5.29 1 Yes Yes 8 9 2 1
R:R:A274 R:R:W234 5.19 1 No Yes 8 9 1 1
R:R:S277 R:R:W234 7.41 0 No Yes 9 9 2 1
L:L:?1 R:R:W234 8.05 1 Yes Yes 0 9 0 1
R:R:H238 R:R:Y237 8.71 1 Yes Yes 8 6 2 1
R:R:N241 R:R:Y237 11.63 1 Yes Yes 6 6 2 1
R:R:R267 R:R:Y237 3.09 1 Yes Yes 4 6 2 1
L:L:?1 R:R:Y237 4.84 1 Yes Yes 0 6 0 1
R:R:N241 R:R:R267 12.05 1 Yes Yes 6 4 2 2
R:R:I271 R:R:R267 3.76 0 No Yes 5 4 1 2
L:L:?1 R:R:N268 5.66 1 Yes No 0 4 0 1
L:L:?1 R:R:I271 15.14 1 Yes No 0 5 0 1
L:L:?1 R:R:A274 3.71 1 Yes No 0 8 0 1
L:L:?1 R:R:F275 9.33 1 Yes Yes 0 6 0 1
R:R:F169 R:R:R171 2.14 1 No No 3 4 1 2
R:R:C97 R:R:G98 1.96 1 Yes No 6 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
100.00Consensusblt_offOrthosteric Ligandblt1_off
56.25Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
50.00Single5X93K-87945X93-ETB-K-8794
50.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
50.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
50.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
50.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
50.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
50.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
50.00Single8K5CAcipimox8K5C-HCA2-Acipimox
50.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
50.00Consensushcar_onOrthosteric Ligandhca_on
47.37Single5X33BIIL2605X33-BLT1-BIIL260
47.37Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
47.37Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
47.37Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
47.37Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
47.06Single4YAYZD-71554YAY-AT1-ZD-7155
47.06Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
47.06Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
47.06Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
47.06Single8K5DGSK2560738K5D-HCA2-GSK256073
47.06Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
47.06Consensusgi_hcarOrthosteric Ligandgi_hca
47.06Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
45.83Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
45.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
45.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
45.00Consensusendothelin_offOrthosteric Ligandetb_off
45.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
44.44Single6D26Fevipiprant6D26-DP2-Fevipiprant
44.44Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
44.44Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
44.44Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
43.75Single4S0VSuvorexant4S0V-OX2-Suvorexant
43.75Single6TPJSuvorexant6TPJ-OX2-Suvorexant
43.75Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
43.75Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
42.86Single7SK9CCX6627SK9-ACKR3-CCX662
42.86Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
42.31Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
42.11Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
42.11Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
42.11Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
42.11Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
41.18Single2YDOAdenosine2YDO-A2A-Adenosine
41.18Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
41.18Single6TP3Nemorexant6TP3-OX1-Nemorexant
41.18Single6V9SGTPL114036V9S-OX1-GTPL11403
41.18Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
41.18Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
41.18Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
40.91Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.00Single6A93Risperidone6A93-5-HT2A-Risperidone
40.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
40.00Single7DFPSpiperone7DFP-D2-Spiperone
40.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
40.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
40.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
40.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
40.00Consensusdp_offOrthosteric Liganddp2_off
39.29Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
39.29Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
39.13Single3QAKUK-4320973QAK-A2A-UK-432097
39.13Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
38.89Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
38.89Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
38.89Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
38.89Single5TGZAM65385TGZ-CB1-AM6538
38.89Single6D27CAY104716D27-DP2-CAY10471
38.89Single6TOTLemborexant6TOT-OX1-Lemborexant
38.89Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
38.89Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
38.89Single7UL4Alvimopan7UL4-μ-Alvimopan
38.89Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
38.89Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
38.89Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
38.89Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
38.46Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
38.10Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
38.10Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
38.10Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
37.50Single3OE9IT1t3OE9-CXCR4-IT1t
37.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
37.50Single5WF5UK-4320975WF5-A2A-UK-432097
37.50Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
37.50Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
37.50Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
37.50Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
37.50Single8K5BNiacin8K5B-HCA2-Niacin
37.50Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
37.04Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
36.84Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
36.84Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
36.84Single5WQCEMPA5WQC-OX2-EMPA
36.84Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
36.84Single6TP6Filorexant6TP6-OX1-Filorexant
36.84Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
36.84Single7SINNPS-21437SIN-CaS-NPS-2143
36.84Single7SINNPS-21437SIN-CaS-NPS-2143
36.84Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single4UG2CGS216804UG2-A2A-CGS21680
36.36Single5WF6UK-4320975WF6-A2A-UK-432097
36.36Single5ZTYAM102575ZTY-CB2-AM10257
36.36Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
36.36Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
36.36Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
36.36Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.36Consensuslpl_offOrthosteric Ligands1p_off lpa_off
36.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
36.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
36.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
35.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
35.29Single5WS3EMPA5WS3-OX2-EMPA
35.29Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
35.29Single8IHKAcifran8IHK-HCA3-Acifran
35.29Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8IWESpermidine8IWE-TAAR9-Spermidine
35.29Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
35.29Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensusgt_class-aOrthosteric Ligandgt_opsin
35.29Consensusgt_opsinOrthosteric Ligandgt_sensory
35.29Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.29Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.00Single2YDVNECA2YDV-A2A-NECA
35.00Single4UHRCGS216804UHR-A2A-CGS21680
35.00Single5G53NECA5G53-A2A-NECA-Gs
35.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
35.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
35.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
35.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
35.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
35.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
35.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
35.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
35.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
35.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
35.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
34.78Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
34.78Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
34.78Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
34.78Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.62Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
34.62Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
34.62Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
34.62Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
34.62Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.48Single5GLHEndothelin-15GLH-ETB-Endothelin-1
33.33Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
33.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
33.33Single4AMIBucindolol4AMI-β1-Bucindolol
33.33Single4LDEBI1671074LDE-β2-BI167107
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
33.33Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
33.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
33.33Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
33.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single6ZG4HTL00099366ZG4-M1-HTL0009936
33.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
33.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
33.33Single7YITNalfurafine7YIT-κ-Nalfurafine
33.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
33.33Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
33.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
33.33Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
33.33Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
33.33Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
33.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
33.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
33.33Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
33.33Consensuss1p_offOrthosteric Ligands1p1_off
33.33Consensussensory_onOrthosteric Ligandopsin_on
32.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
32.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
32.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
32.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
31.82Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
31.82Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
31.82Single6IBLArformoterol6IBL-β1-Arformoterol
31.82Single7EZCUKA7EZC-A2A-UKA
31.82Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
31.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
31.82Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
31.82Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
31.82Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
31.82Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
31.82Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.58Single2Y01Dobutamine2Y01-β1-Dobutamine
31.58Single2Y04Salbutamol2Y04-β1-Salbutamol
31.58Single3NY8ICI 118-5513NY8-β2-ICI 118-551
31.58Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
31.58Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
31.58Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
31.58Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.58Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
31.58Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
31.58Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
31.58Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
31.58Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
31.58Single6GPSMK08126GPS-CCR2-MK0812
31.58Single6IIVDaltroban6IIV-TP-Daltroban
31.58Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
31.58Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7BU7BI1671077BU7-β1-BI167107
31.58Single7F83PF-051904577F83-Ghrelin-PF-05190457
31.58Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
31.58Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
31.58Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.58Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
31.58Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.58Single8JJOAlprenolol8JJO-β2-Alprenolol
31.58Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
31.58Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
31.58Consensusadenosine_onOrthosteric Liganda1_on a2_on
31.58Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
31.58Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
31.58Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Consensusblt_onOrthosteric Ligandblt1_on
31.58Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Consensushcar_offOrthosteric Ligandsuccinate_off
31.58Consensushistamine_onOrthosteric Ligandh1_on h4_on
31.58Consensusleuko_onOrthosteric Ligandblt_on
31.58Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
31.58Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.58Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
31.58Consensusnucleotide_onOrthosteric Ligandadenosine_on
31.58Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
31.58Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
31.25Single3OE6IT1t3OE6-CXCR4-IT1t
31.25Single3OE8IT1t3OE8-CXCR4-IT1t
31.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
31.25Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
31.25Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
31.25Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
31.25Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
31.03Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.77Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.77Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
30.77Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
30.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
30.43Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single8X5YAstemizole8X5Y-H1-Astemizole
30.43Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
30.43Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
30.43Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
30.43Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
30.43Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
30.00Single2Y00Dobutamine2Y00-β1-Dobutamine
30.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
30.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
30.00Single5CGCHTL142425CGC-mGlu5-HTL14242
30.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
30.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
30.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
30.00Single5XPRBosentan5XPR-ETB-Bosentan
30.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
30.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
30.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
30.00Single6GPXMK08126GPX-CCR2-MK0812
30.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
30.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.00Single6PS6Timolol6PS6-β2-Timolol
30.00Single7C4SS1P7C4S-S1P3-S1P
30.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
30.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
30.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
30.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
30.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
30.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
30.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
30.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
30.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
30.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
30.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
30.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
30.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
30.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
30.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
30.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
30.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
30.00Consensusep_offOrthosteric Ligandep4_off
30.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
30.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
30.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
30.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
29.63Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.63Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.63Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
29.41Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
29.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
29.41Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
29.41Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
29.41Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
29.41Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
29.41Consensusgo_class-b2Orthosteric Ligandgo_adhesion
29.41Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
29.17Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
29.17Single4IARErgotamine4IAR-5-HT1B-Ergotamine
29.17Single4XT1Fractalkine4XT1-US28-Fractalkine
29.17Single7F8XNN90567F8X-CCKA-NN9056
29.17Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
29.17Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
29.17Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
29.17Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.17Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
29.17Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
29.17Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensussst_onOrthosteric Ligandsst2_on sst4_on
28.57Single4DJHJDTic4DJH-κ-JDTic
28.57Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
28.57Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
28.57Single4RWADIPP-NH24RWA-δ-DIPP-NH2
28.57Single4U15Tiotropium4U15-M3-Tiotropium
28.57Single4XT3Fractalkine4XT3-US28-Fractalkine
28.57Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
28.57Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
28.57Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
28.57Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
28.57Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
28.57Single6FJ3PTH6FJ3-PTH1-PTH
28.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
28.57Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
28.57Single6OL9Tiotropium6OL9-M5-Tiotropium
28.57Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.57Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
28.57Single7PX4PSB-21137PX4-A2A-PSB-2113
28.57Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
28.57Single7TUYGSK682753A7TUY-GPR183-GSK682753A
28.57Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
28.57Single7W41PD1762527W41-BB2-PD176252
28.57Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
28.57Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
28.57Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8E0GBU728E0G-μ-BU72
28.57Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
28.57Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
28.57Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
28.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
28.57Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
28.57Consensusa2_onOrthosteric Liganda2a_on a2b_on
28.57Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusadenosine_offOrthosteric Liganda1_off a2_off
28.57Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
28.57Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
28.57Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
28.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
28.57Consensusbombesin_offOrthosteric Ligandbb2_off
28.57Consensuscck_onOrthosteric Ligandccka_on cckb_on
28.57Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.57Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
28.57Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
28.57Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
28.57Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
28.57Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.57Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
28.57Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
28.57Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
28.57Consensusrelaxin_onOrthosteric Ligandrxfp4_on
28.57Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
28.12Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single6HLOAprepitant6HLO-NK1-Aprepitant
28.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
28.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
28.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.78Single3ODUIT1t3ODU-CXCR4-IT1t
27.78Single3PWHZM2413853PWH-A2A-ZM241385
27.78Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.78Single6B73PubChem 1319551386B73-κ-PubChem 131955138
27.78Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Single6KUXRS-799486KUX-α2a-RS-79948
27.78Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
27.78Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
27.78Single6TODEMPA6TOD-OX1-EMPA-Na
27.78Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
27.78Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
27.78Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
27.78Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
27.78Single7XRRLemborexant7XRR-OX2-Lemborexant
27.78Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
27.78Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGVEpinephrine8GGV-β2-Epinephrine
27.78Single8GGWEpinephrine8GGW-β2-Epinephrine
27.78Single8GGXEpinephrine8GGX-β2-Epinephrine
27.78Single8GH0Epinephrine8GH0-β2-Epinephrine
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
27.78Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Consensusalpha1_onOrthosteric Ligandalpha1a_on
27.78Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
27.78Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
27.78Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Consensusorexin_offOrthosteric Ligandox2_off ox1_off
27.59Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
27.27Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.27Single5CXVTiotropium5CXV-M1-Tiotropium
27.27Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
27.27Single6CM4Risperidone6CM4-D2-Risperidone
27.27Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
27.27Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
27.27Single6IIURamatroban6IIU-TP-Ramatroban
27.27Single6MXTSalmeterol6MXT-β2-Salmeterol
27.27Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.27Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.27Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.27Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
27.27Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
27.27Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
27.27Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
27.27Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
27.27Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
27.27Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8JJ8Formoterol8JJ8-β2-Formoterol
27.27Single8JJLOlodaterol8JJL-β2-Olodaterol
27.27Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
27.27Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
27.27Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
27.27Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.27Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
27.27Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.27Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
27.27Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
27.27Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
26.92Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
26.92Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
26.92Consensusangiotensin_onOrthosteric Ligandat1_on
26.92Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.92Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
26.67Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
26.67Single6IGLIRL16206IGL-ETB-IRL1620
26.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
26.67Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
26.32Single3REYPubChem 56973REY-A2A-PubChem 5697
26.32Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
26.32Single6AQFZM2413856AQF-A2A-ZM241385
26.32Single6IQLL7458706IQL-D4-L745870
26.32Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6MH8ZM2413856MH8-A2A-ZM241385
26.32Single6PS4ICI 118-5516PS4-β2-ICI 118-551
26.32Single6TPKRetosiban6TPK-OT-Retosiban
26.32Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
26.32Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
26.32Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.32Single7AROLUF58337ARO-A2A-LUF5833-Na
26.32Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
26.32Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
26.32Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.32Single7T32ZM2413857T32-A2A-ZM241385
26.32Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
26.32Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.32Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.32Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
26.32Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.32Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GGIEpinephrine8GGI-β2-Epinephrine
26.32Single8GGQEpinephrine8GGQ-β2-Epinephrine
26.32Single8GGTEpinephrine8GGT-β2-Epinephrine
26.32Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
26.32Single8K2WAMG4878K2W-CXCR3-AMG487
26.32Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
26.32Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
26.32Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
26.32Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
26.32Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
26.32Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.32Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
26.32Consensusvasopressin-ot_offOrthosteric Ligandot_off
26.09Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
26.09Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
26.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.09Single5CGDHTL142425CGD-mGlu5-HTL14242
26.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.09Single6H7LDobutamine6H7L-β1-Dobutamine
26.09Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
26.09Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
26.09Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.09Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
26.09Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
26.09Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
26.09Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.09Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
26.09Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
26.09Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
26.09Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
26.09Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
26.09Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
26.09Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.93Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.93Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
25.93Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.93Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.93Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
25.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
25.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.00Single4DAJTiotropium4DAJ-M3-Tiotropium
25.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
25.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4MQSIperoxo4MQS-M2-Iperoxo
25.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
25.00Single4U14Tiotropium4U14-M3-Tiotropium
25.00Single5DSGTiotropium5DSG-M4-Tiotropium
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
25.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
25.00Single6H7MSalbutamol6H7M-β1-Salbutamol
25.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
25.00Single6PS1Timolol6PS1-β2-Timolol
25.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
25.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
25.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
25.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
25.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
25.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
25.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
25.00Single8GGNEpinephrine8GGN-β2-Epinephrine
25.00Single8GGOEpinephrine8GGO-β2-Epinephrine
25.00Single8GGUEpinephrine8GGU-β2-Epinephrine
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
25.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
25.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
25.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
25.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
25.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
25.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
25.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
25.00Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
25.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
25.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
25.00Consensustar_onOrthosteric Ligandta1_on
24.24Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.14Single7SK3CXCL127SK3-ACKR3-CXCL12
24.14Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
24.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
24.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
24.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
24.00Consensusclass-d_offOrthosteric Ligandste2_off
24.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
24.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
24.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
24.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
23.81Single5C1MBU725C1M-μ-BU72
23.81Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.81Single5N2SPSB365N2S-A1-PSB36
23.81Single5NM2ZM2413855NM2-A2A-ZM241385-Na
23.81Single5WIUNemonapride5WIU-D4-Nemonapride
23.81Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.81Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.81Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.81Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
23.81Single6LPLZM2413856LPL-A2A-ZM241385-Na
23.81Single6LUQHaloperidol6LUQ-D2-Haloperidol
23.81Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
23.81Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
23.81Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
23.81Single6S0QZM2413856S0Q-A2A-ZM241385
23.81Single6WQAZM2413856WQA-A2A-ZM241385-Na
23.81Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.81Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.81Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
23.81Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
23.81Single7RM5ZM2413857RM5-A2A-ZM241385-Na
23.81Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
23.81Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
23.81Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
23.81Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
23.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.81Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
23.81Single7XKAEpinephrine7XKA-β2-Epinephrine
23.81Single8EA0Iperoxo8EA0-M3-Iperoxo
23.81Single8FYNZM2413858FYN-A2A-ZM241385-Na
23.81Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
23.81Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
23.81Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
23.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.81Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.81Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
23.81Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
23.81Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
23.81Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
23.81Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
23.81Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
23.81Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.81Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
23.81Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
23.81Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
23.81Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
23.81Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
23.81Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
23.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.53Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.53Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
23.53Single3UZAGTPL92363UZA-A2A-GTPL9236
23.53Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.53Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
23.53Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
23.53Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
23.53Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single8GGREpinephrine8GGR-β2-Epinephrine
23.53Single8GGZEpinephrine8GGZ-β2-Epinephrine
23.53Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
23.08Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
23.08Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
23.08Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
23.08Single7SK5CXCL127SK5-ACKR3-CXCL12
23.08Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
23.08Consensussst_offOrthosteric Ligandsst2_off
23.08Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
22.73Single3P0GBI1671073P0G-β2-BI167107
22.73Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.73Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
22.73Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
22.73Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
22.73Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.73Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.73Single5XRAAM115425XRA-CB1-AM11542
22.73Single6J20Aprepitant6J20-NK1-Aprepitant
22.73Single6J21Aprepitant6J21-NK1-Aprepitant
22.73Single6WGTLSD6WGT-5-HT2A-LSD
22.73Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
22.73Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
22.73Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
22.73Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
22.73Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
22.73Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
22.73Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
22.73Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
22.73Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
22.73Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
22.73Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
22.73Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.73Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
22.73Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
22.73Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
22.73Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.73Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.73Consensus5ht5_offOrthosteric Ligand5ht5a_off
22.73Consensuschemerin_onOrthosteric Ligandcml1_on
22.73Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.73Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
22.73Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
22.73Consensushistamine_offOrthosteric Ligandh1_off
22.73Consensuslpa_offOrthosteric Ligandlpa1_off
22.73Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
22.73Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
22.73Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
22.73Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
22.58Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.58Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.58Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
22.58Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
22.22Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
22.22Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
22.22Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single3PBLEticlopride3PBL-D3-Eticlopride
22.22Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
22.22Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
22.22Single6PT2KGCHM076PT2-δ-KGCHM07
22.22Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.22Single6W25SHU91196W25-MC4-SHU9119-Ca
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
22.22Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
22.22Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
22.22Single7XNACYN1548067XNA-SST2-CYN154806
22.22Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
22.22Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGSEpinephrine8GGS-β2-Epinephrine
22.22Single8GGYEpinephrine8GGY-β2-Epinephrine
22.22Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
22.22Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.22Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
22.22Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.22Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.22Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
22.22Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
22.22Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
22.22Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
21.88Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.88Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.74Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.74Single4N4WSANT-14N4W-SMO-SANT-1
21.74Single6HLPNetupitant6HLP-NK1-Netupitant
21.74Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
21.74Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
21.74Single6OS2TRV0266OS2-AT1-TRV026
21.74Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
21.74Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
21.74Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.74Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
21.74Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
21.74Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.74Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.74Single8WU1KCA8WU1-CB1-KCA-Arrestin1
21.74Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
21.74Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
21.74Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.74Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
21.74Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.74Consensusclass-b2_onOrthosteric Ligandadgrg_on
21.74Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
21.74Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.74Consensusgi_class-fOther Ligandgi_frizzled
21.74Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.74Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
21.74Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.74Consensusgs_steroidOrthosteric Ligandgs_bileacid
21.74Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
21.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.43Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
21.43Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
21.43Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.43Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
21.21Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.21Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.21Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
21.05Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.05Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
21.05Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
21.05Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
21.05Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
21.05Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
21.05Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.05Single5U09Taranabant5U09-CB1-Taranabant
21.05Single6AKXA4R6AKX-CCR5-A4R
21.05Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.05Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.05Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
21.05Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
21.05Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.05Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
21.05Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
21.05Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
21.05Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
21.05Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.05Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.05Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
21.05Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
21.05Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
21.05Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
21.05Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.05Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
21.05Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
20.83Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
20.83Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
20.83Single6K1QIRL25006K1Q-ETB-IRL2500
20.83Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
20.83Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
20.83Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
20.83Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.83Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
20.83Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.83Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.83Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.83Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.83Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.83Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.83Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.83Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
20.83Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.83Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
20.83Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusorexin_onOrthosteric Ligandox2_on
20.83Consensussteroid_onOrthosteric Ligandbileacid_on
20.69Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
20.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
20.69Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.69Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
20.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
20.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM2413855JTB-A2A-ZM241385
20.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
20.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
20.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
20.00Single6TPNHTL66416TPN-OX2-HTL6641
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
20.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
20.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
20.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
20.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
20.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
20.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
20.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
20.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGKEpinephrine8GGK-β2-Epinephrine
20.00Single8GGMEpinephrine8GGM-β2-Epinephrine
20.00Single8GGPEpinephrine8GGP-β2-Epinephrine
20.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
20.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
20.00Consensusclass-d_offOrthosteric Ligandste2_off
20.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
20.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
20.00Consensussensory_offOrthosteric Ligandopsin_off
19.44Consensuspth_onOrthosteric Ligandpth1_on pth2_on
19.35Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
19.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.35Consensusgo_class-b1Orthosteric Ligandgo_crf
19.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.23Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
19.23Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
19.23Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
19.23Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
19.23Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
19.23Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
19.23Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
19.05Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
19.05Single3EMLZM2413853EML-A2A-ZM241385
19.05Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
19.05Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
19.05Single5K2AZM2413855K2A-A2A-ZM241385-Na
19.05Single5VRAZM2413855VRA-A2A-ZM241385-Na
19.05Single6FFHFenobam6FFH-mGlu5-Fenobam
19.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
19.05Single6LPJZM2413856LPJ-A2A-ZM241385-Na
19.05Single6LPKZM2413856LPK-A2A-ZM241385-Na
19.05Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
19.05Single6S0LZM2413856S0L-A2A-ZM241385
19.05Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
19.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
19.05Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
19.05Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
19.05Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.05Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.05Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
19.05Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
19.05Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
19.05Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
19.05Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
19.05Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
19.05Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
19.05Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
19.05Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
19.05Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
19.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
19.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
19.05Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8X63Mepyramine8X63-H1-Mepyramine
19.05Single8X64Desloratadine8X64-H1-Desloratadine
19.05Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
19.05Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
19.05Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
19.05Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
19.05Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
18.75Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.75Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
18.75Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
18.75Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.75Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
18.75Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
18.75Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.75Single8PWNTheophylline8PWN-A2A-Theophylline
18.75Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
18.75Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.75Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.75Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
18.52Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
18.52Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
18.52Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
18.52Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
18.42Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.42Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.18Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
18.18Single5TVNLSD5TVN-5-HT2B-LSD
18.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
18.18Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.18Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.18Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.18Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
18.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
18.18Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
18.18Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
18.18Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
18.18Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single7WC6LSD7WC6-5-HT2A-LSD
18.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
18.18Single8GNEKW-63568GNE-A2A-KW-6356-Na
18.18Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
18.18Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
18.18Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
18.18Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
18.18Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.86Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.86Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
17.86Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
17.86Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
17.65Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
17.65Single3RFMCaffeine3RFM-A2A-Caffeine
17.65Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.65Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.65Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
17.65Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
17.65Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
17.39Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.39Single5XR8AM8415XR8-CB1-AM841
17.39Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.39Single6E59L-7607356E59-NK1-L-760735
17.39Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.39Single7EPENAM5637EPE-mGlu-NAM563
17.39Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
17.39Single7P2L4YI7P2L-mGlu5-4YI
17.39Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
17.39Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
17.39Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
17.39Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
17.39Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.39Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
17.39Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
17.39Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
17.39Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
17.39Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
17.39Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Consensuslpa_onOrthosteric Ligandlpa1_on
17.39Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.39Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.24Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
17.24Consensusclass-d_onOrthosteric Ligandste2_on
17.24Consensusgi_class-dOrthosteric Ligandgi_ste
17.24Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.24Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.24Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.24Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.14Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.07Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
16.67Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
16.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
16.67Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
16.67Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
16.67Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
16.67Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
16.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Consensuschemokine_offOrthosteric Ligandcxcr_off
16.67Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
16.67Consensuscxcr_offOrthosteric Ligandcxcr4_off
16.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
16.67Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.22Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
16.13Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.13Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.13Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
16.13Consensusclass-d_onOrthosteric Ligandste2_on
16.13Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.13Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
16.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
16.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
16.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
15.79Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
15.79Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.79Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.79Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
15.79Single7SRQLSD7SRQ-5-HT2B-LSD
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.79Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.79Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.79Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8GH1Epinephrine8GH1-β2-Epinephrine
15.79Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
15.79Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.79Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.79Consensusclass-t_onOrthosteric Ligandtaste2_on
15.79Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Consensusgs_class-tOrthosteric Ligandgs_taste
15.79Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.79Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
15.79Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.62Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
15.62Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.62Consensusgi_class-dOrthosteric Ligandgi_ste
15.62Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
15.38Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
15.38Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
15.38Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
15.38Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
15.38Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.38Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.15Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.15Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.15Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.15Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
15.15Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.15Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
15.00Single5DHHSB-6121115DHH-NOP-SB-612111
15.00Single5K2DZM2413855K2D-A2A-ZM241385
15.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
15.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.00Single7F8ULintitript7F8U-CCKA-Lintitript
15.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
15.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
15.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
15.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
15.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
15.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.81Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.81Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
14.81Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
14.81Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
14.81Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
14.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single3RZECidoxepin3RZE-H1-Cidoxepin
14.29Single5NLXZM2413855NLX-A2A-ZM241385-Na
14.29Single5UVIZM2413855UVI-A2A-ZM241385
14.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
14.29Single6VI4JDTic6VI4-κ-JDTic
14.29Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.29Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
14.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
14.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
14.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
14.29Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
14.29Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
14.29Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
14.29Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
14.29Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Single8GGLEpinephrine8GGL-β2-Epinephrine
14.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensus5ht5_onOrthosteric Ligand5ht5a_on
14.29Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
14.29Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.29Consensusgnrh_offOrthosteric Ligandgnrh1_off
14.29Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
13.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.89Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
13.79Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.64Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
13.64Single5T04Neurotensin5T04-NTS1-Neurotensin
13.64Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
13.64Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
13.64Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
13.64Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.64Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.64Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
13.64Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.64Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.64Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
13.64Consensustachykinin_offOrthosteric Ligandnk1_off
13.51Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
13.51Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.51Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
13.51Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
13.51Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.33Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.33Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.33Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.04Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
13.04Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.04Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.04Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.04Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.04Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.04Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.04Single8QOTNanobody E8QOT-μ-Nanobody E
12.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
12.90Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
12.90Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.90Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.50Single5TZR-5TZR-FFA1 (GPR40)-MK8666
12.50Single5V56TC1145V56-SMO-TC114
12.50Single5V57TC1145V57-SMO-TC114
12.50Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50Single6OS1TRV0266OS1-AT1-TRV026
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single6W25Ca6W25-MC4-SHU9119-Ca
12.50Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.50Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.50Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
12.50Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.50Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
12.50Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
12.50Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
12.50Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
12.50Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.20Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.20Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.12Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.12Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.12Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.12Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.12Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
12.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.00Single4XESNeurotensin4XES-NTS1-Neurotensin
12.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
12.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
12.00Consensusnts_offOrthosteric Ligandnts1_off
12.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
11.76Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.54Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
11.54Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
11.54Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.54Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single6KNMJN241-96KNM-Apelin-JN241-9
11.11Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.11Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
11.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
11.11Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.11Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.71Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
10.71Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.71Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.71Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
10.53Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.53Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.53Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
10.53Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
10.34Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
10.34Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
10.26Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
10.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
10.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
10.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
10.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
9.68Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
9.68Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
9.52Single6ME2Ramelteon6ME2-MT1-Ramelteon
9.52Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
9.52Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
9.52Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
9.52Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.52Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
9.52Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.52Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
9.09Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.09Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
9.09Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
9.09Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
9.09Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
8.70Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
8.70Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.70Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.70Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
8.70Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.57Single6LMLGlucagon6LML-Glucagon-Glucagon
8.33Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
8.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.33Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.33Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
8.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
8.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
8.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
8.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
8.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
7.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
7.69Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Consensusnts_onOrthosteric Ligandnts1_on
7.41Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.41Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.41Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.82Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.56Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.26Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.26Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.00Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
5.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
5.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.00Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
5.00Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
5.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.88Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
4.76Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
4.76Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
4.76Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.55Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.55Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.55Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
4.55Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.55Consensusclass-f_offOrthosteric Ligandsmo_off
4.55Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
4.35Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
4.35Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
4.35Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.35Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.17Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
4.17Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
4.17Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
4.17Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.17Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.17Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.17Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
4.17Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
4.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
4.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
4.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
3.85Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
3.85Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.85Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.85Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
3.70Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
3.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
3.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
3.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.70Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
3.57Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
3.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
3.23Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.78Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
2.70Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.63Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.63Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.63Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.56Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.44Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.44Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.17Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.08Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7K15
Class A
SubFamily Lipid
Type Leukotriene
SubType BLT1
Species Homo sapiens
Ligand MKD046
Other Ligand(s) Na
Protein Partners -
PDB Resolution 2.88
Date 2021-02-17
D.O.I. 10.1038/s41467-021-23149-1
Net Summary
Imin 3.02
Number of Linked Nodes 277
Number of Links 322
Number of Hubs 43
Number of Links mediated by Hubs 158
Number of Communities 7
Number of Nodes involved in Communities 62
Number of Links involved in Communities 91
Path Summary
Number Of Nodes in MetaPath 83
Number Of Links MetaPath 82
Number of Shortest Paths 76275
Length Of Smallest Path 3
Average Path Length 14.6888
Length of Longest Path 37
Minimum Path Strength 1.43
Average Path Strength 5.99407
Maximum Path Strength 24.04
Minimum Path Correlation 0.7
Average Path Correlation 0.932643
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 52.9092
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.0108
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeVRJ
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeVRJ
NameN-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide
Synonyms
Identifier~{N}-~{tert}-butylsulfonyl-4-fluoranyl-2-[(3~{S},4~{R})-4-oxidanyl-3-(pyridin-2-ylmethyl)-3,4-dihydro-2~{H}-chromen-7-yl]benzamide
FormulaC26 H27 F N2 O5 S
Molecular Weight498.566
SMILESCC(C)(C)S(=O)(=O)NC(=O)c1ccc(cc1c2ccc3c(c2)OC[C@@H]([C@H]3O)Cc4ccccn4)F
PubChem129208412
Formal Charge0
Total Atoms62
Total Chiral Atoms2
Total Bonds65
Total Aromatic Bonds18

CodeNA
PDB ResiduesI:I:?1
Environment DetailsOpen EMBL-EBI Page
CodeNA
NameSODIUM ION
Synonyms
Identifiersodium(+1) cation
FormulaNa
Molecular Weight22.99
SMILES[Na+]
PubChem
Formal Charge1
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ15722
Sequence
>7K15_Chain_R
GVEFISLLA IILLSVALA VGLPGNSFV VWSILKRMQ KRSVTALMV 
LNLALADLA VLLTAPFFL HFLAQGTWS FGLAGCRLC HYVCGVSMY 
ASVWLITAM SLDRYLAVA RPFVSQKLR TKAMARRVL AGIWVLSFL 
LATPVLAYR TVVPWKTNM SLCFPRYPS EGHRAFHLI FEAVTGFLL 
PFLIVVASY SDIGRRLQA RRFRRSRRT GRLVVLIIL TFAAFWLPY 
HVVNLAEAG RALAGQAAG LGLVGKRLS LARNVLIAL AFLSSSVNP 
VLYAFAGGG LLRSAGVGF VAKLLEGTG AEFLEVLFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
blt1_off7K15-BLT1-MKD046-Na

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5X33ALipidLeukotrieneBLT1Cavia porcellusBIIL260--3.72018-01-0310.1038/nchembio.2547
7VKTALipidLeukotrieneBLT1Homo sapiensLTB4-Gi1/&β;1/&γ;22.92022-03-0910.1038/s41467-022-28820-9




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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