Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 1.49189602
2G.S1.06 3.84615458
3G.H1.01 3.56874559
4G.S2.03 5.49203419
5G.S2.05 5.21971413
6G.S2.06 5.86035459
7G.S2.08 7.584274165
8G.S3.03 6.8934557
9G.S3.04 7.71892416
10G.S3.05 3.6674457
11G.S3.06 7.3773515
12G.s3h2.03 3.74118519
13G.H2.06 5.12581519
14G.H2.07 3.78656719
15G.h2s4.01 5.34322519
16G.S4.04 5.7379449
17G.s4h3.04 5.395726128
18G.s4h3.05 6.203914129
19G.H3.01 5.87924189
20G.H3.09 5.04719749
21G.H3.13 3.71267545
22G.H3.14 4.86687408
23G.H3.17 6.38137685
24G.H3.18 5.446234179
25G.S5.03 2.72919408
26G.S5.04 3.27465549
27G.S5.05 3.43869669
28G.S5.07 3.38941569
29G.HG.04 4.76847509
30G.hgh4.02 4.267316197
31G.hgh4.05 5.78317507
32G.H4.03 5.05723504
33G.H4.05 3.401444204
34G.H4.15 4.10106548
35G.H4.16 4.11761443
36G.h4s6.02 4.69388448
37G.S6.02 6.441795307
38G.H5.03 4.75471568
39G.H5.08 5.781954168
40G.H5.13 4.33483408
41G.H5.20 2.8741409
42G.H5.26 3.621675215
43b.1x1 1.39549504
44b.1x2 1.47567401
45b.1x4 1.33576508
46b.b1x4 3.144385247
47b.b1x6 7.17807409
48b.l1x3 7.11849679
49b.b2x1 6.86421588
50b.b2x5 6.3755607
51b.l3x2 4.6045579
52b.b4x3 3.655724137
53b.b4x6 9.97626579
54b.l4x2 9.28001404
55b.b5x2 5.03827407
56b.b5x3 6.41002679
57b.b5x5 4.64902405
58b.b5x7 5.20347407
59b.l5x1 3.684245138
60b.l5x2 2.82273406
61b.l5x5 6.35519719
62b.b6x5 3.70709606
63b.l6x5 5.673214144
64b.b7x1 5.289165144
65b.l7x2 3.72143519
66b.b8x4 5.205485136
67b.l8x5 1.95401503
68b.b9x4 5.98819409
69b.l9x3 6.33423619
70b.l9x6 4.07181918
71b.b10x5 4.06117509
72b.l11x2 6.33496519
73b.b12x6 7.54397718
74b.b13x7 7.03931537
75b.l13x3 6.03292739
76b.l13x6 4.66194519
77b.l13x7 4.54042439
78b.b14x3 4.23532435
79b.b15x1 6.22854539
80b.b15x2 5.01151416
81b.b15x3 4.34387439
82b.l15x1 4.65329417
83b.l15x2 4.59646539
84b.b16x4 9.49362436
85b.b16x5 4.25533405
86b.b16x6 8.13213638
87b.b17x5 6.78238417
88b.b17x7 7.3473418
89b.l17x3 8.02972619
90b.l17x6 6.41574419
91b.b18x3 4.51198418
92b.b18x5 4.57113405
93b.l18x1 5.000498106
94b.l18x2 4.990354107
95b.b19x2 5.51825716
96b.b19x4 4.98087518
97b.l19x2 6.09437519
98b.b20x4 9.57589518
99b.b20x6 6.69618516
100b.b20x7 3.1624409
101b.b21x1 6.58344517
102b.b21x5 5.19105404
103b.b21x7 5.65357505
104b.l21x2 3.79965404
105b.l21x7 3.699414115
106b.b22x5 4.229946107
107b.l22x5 5.626545239
108b.b23x6 5.77667117
109b.l23x1 7.87163406
110b.b24x4 6.465854116
111b.b24x6 5.091384118
112b.l24x3 3.56596405
113b.l25x3 7.74838599
114b.l27x1 6.287784257
115b.l28x1 9.8672789
116b.l28x2 7.25322499
117b.b28x4 6.6912496
118b.b28x6 7.20632599
119g.h1x1 0.840708402
120g.h1x12 1.97329406
121g.l1x4 2.45904608
122g.h2x11 6.121944106
123g.ctx3 6.06656409
124g.ctx6 3.16453406
125g.ctx16 4.191856248
126NT 6.68986925
1271x50 5.64954409
1281x57 2.49598408
129I1 2.609374297
1302x40 2.974576298
1312x42 2.76888508
1322x46 4.365974289
1332x50 5.325015289
1342x57 3.94528426
1352x61 2.65088406
1362x64 2.30165623
1373x25 4.88787429
1383x29 4.22332424
1393x37 2.73885406
1403x49 2.73199609
1413x50 4.901595229
142I2x53 2.60121607
1434x50 3.44852409
144E2 10.29212225
1455x43 4.1811425
1465x50 3.08714407
1475x58 3.68306709
1485x60 3.60484405
1495x69 1.62819405
150I3 2.820814303
1516x32 2.696244218
1526x48 4.60932608
153E3 4.19514921
1547x35 2.65352424
1557x52 1.98656409
1567x53 4.539354229
157Lig 4.58791620
158H.HA.19 0.09055554156
159H.HC.03 0.04426675153
160H.HC.07 0.07288894156
161H.HD.07 0.101889405
162H.hdhe.01 0.0812963606
163H.HE.05 0.0777333507
164H.HE.06 0.0953889407
165H.HF.06 0.132167406
166E1x50 3.75019420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.HN.43 b.b5x3 10.48566.93858NoYes099
2G.HN.39 G.HN.43 10.10932.64689NoNo059
3b.b4x6 b.b5x3 13.941510.5979YesYes799
4b.b3x2 b.b4x6 22.5124.27122NoYes059
5b.b2x5 b.b3x2 22.705211.9119YesNo075
6b.b2x3 b.b2x5 65.00083.13919NoYes067
7b.b26x2 b.b2x3 65.16265.05825NoNo076
8b.b26x1 b.b26x2 65.48772.73767NoNo097
9b.b26x1 b.l28x1 65.6516.23772NoYes099
10b.b2x1 b.l28x1 88.57246.28144YesYes889
11b.b2x1 b.l3x1 90.905912.8517YesNo089
12b.l3x1 b.l5x5 91.04357.14558NoYes099
13G.h2s4.01 b.l5x5 40.3528.08664YesYes199
14G.H2.07 G.h2s4.01 41.88783.27583YesYes199
15G.H2.04 G.H2.07 1003.77222NoYes099
16G.H2.04 G.H3.08 99.91773.59506NoNo099
17G.H3.08 G.S4.04 99.89734.61161NoYes099
18G.S4.04 G.S5.04 88.60332.63431YesYes499
19G.S5.04 G.S5.06 85.46143.51386YesNo098
20G.S5.06 G.s4h3.01 84.05246.32053NoNo087
21G.HG.04 G.s4h3.01 83.93578.25661YesNo097
22G.HG.04 G.s4h3.04 83.40484.64644YesYes098
23G.HG.07 G.s4h3.04 88.22624.18NoYes1298
24G.HG.07 G.s4h3.02 88.54122.73275NoNo099
25G.s4h3.02 G.s5hg.01 88.24374.61975NoNo099
26G.S5.07 G.s5hg.01 87.5871.90489YesNo099
27G.S5.07 G.s6h5.01 87.27955.80739YesNo699
28G.S5.05 G.s6h5.01 86.07874.83664YesNo699
29G.S4.03 G.S5.05 84.47062.69933NoYes079
30G.S1.04 G.S4.03 84.38683.61892NoNo077
31G.S1.04 G.S3.03 84.30293.29583NoYes077
32G.S3.01 G.S3.03 81.86316.05222NoYes047
33G.S3.01 I2x51 81.05733.35936NoNo047
34G.H5.15 I2x51 80.87422.47936NoNo077
35G.H5.15 G.H5.19 80.78242.3805NoNo078
36G.H5.19 I2x53 80.69035.38217NoYes087
373x49 I2x53 76.72583.62947YesYes097
383x49 G.H5.23 40.15362.72YesNo094
393x50 G.H5.23 40.0273.40172YesNo094
40b.l5x5 b.l7x2 51.32165.13381YesYes199
41G.H2.07 b.l7x2 40.26483.30086YesYes199
42b.l7x2 b.l9x6 10.65242.94847YesYes198
43G.H2.06 b.l9x6 20.38543.65033YesYes198
44G.H2.06 b.l17x6 19.8597.63508YesYes199
45G.H3.06 G.hgh4.02 14.50064.13372NoYes067
46G.H3.06 G.H4.15 14.7415.37547NoYes068
47b.l25x6 b.l28x1 24.33419.3957NoYes889
48b.l2x3 b.l2x5 35.1573.70619NoNo085
49b.b3x1 b.l2x3 34.96385.13944NoNo058
50b.b3x1 b.b6x5 34.77253.41114NoYes056
51b.b2x4 b.b6x5 32.73143.50011NoYes066
52b.b10x4 b.b2x4 32.520511.0237NoNo066
53b.b10x4 b.b14x5 32.31873.12783NoNo065
54b.b14x5 b.l10x1 32.11664.71808NoNo053
55b.b11x1 b.l10x1 31.71194.50892NoNo053
56b.b11x1 b.b12x5 16.01872.98944NoNo056
57b.b12x5 b.b13x5 15.57124.77731NoNo364
58b.b13x5 b.b13x7 15.35756.48625NoYes347
59b.b13x7 b.b16x6 12.188412.2852YesYes378
60b.l17x5 b.l17x6 20.40414.35947NoYes169
61b.l17x5 b.l19x2 20.29863.96625NoYes169
62b.l17x3 b.l19x2 16.23243.62967YesYes199
63b.b19x4 b.l17x3 12.3097.46631YesYes189
64b.l2x5 b.l4x2 35.649422.2135NoYes054
65b.l4x2 g.ctx16 33.40164.84808YesYes048
66b.b2x5 b.l4x1 36.33515.04447YesNo075
67b.l4x1 g.ctx16 36.15653.53667NoYes058
68b.b11x1 b.l10x2 16.58117.84422NoNo055
69b.l10x2 b.l10x4 16.36422.43983NoNo053
70b.b12x7 b.l10x4 15.92136.8375NoNo2693
71b.b12x7 b.l12x3 15.71227.76625NoNo095
72b.b13x2 b.l12x3 15.49454.21994NoNo045
73b.l23x1 b.l25x6 24.243518.956YesNo068
74b.l21x7 b.l23x1 16.95654.90472YesYes056
75b.b23x6 b.l21x7 15.622.66931YesYes1175
76b.b23x6 b.b24x6 12.76366.34242YesYes1178
77b.b21x7 b.b24x6 12.41846.1925YesYes058
783x50 7x53 33.57375.04244YesYes2299
793x43 7x53 65.01954.94833NoYes089
802x46 3x43 64.7273.47386YesNo098
812x46 7x49 50.42544.98417YesNo2899
827x45 7x49 50.57446.01386NoNo099
836x48 7x45 49.72418.32161YesNo089
843x36 6x48 43.36963.34356NoYes068
853x36 Lig 43.06614.49375NoYes060
862x42 3x49 33.56184.18439YesYes089
872x42 3x46 32.82223.42664YesNo089
883x46 7x53 32.66394.18219NoYes2299
89E2 Lig 17.54811.9153YesYes250
90H.hdhe.01 b.b13x2 15.26860.05YesNo064
91H.hdhe.01 H.hdhe.03 13.99630.052YesNo067
92H.HD.07 H.hdhe.03 13.63270.0542222YesNo057
93G.H2.07 b.l9x6 17.26873.18781YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT14.59112YesYes5522
2x64NT2.816812YesYes3512
E2NT19.79762YesYes5512
1x462x543.027440NoNo7821
2x563x322.735470NoNo4521
2x572x613.512422YesYes6612
2x577x424.497442YesNo6611
2x57Lig2.654442YesYes6010
2x603x283.652420NoNo4512
2x60Lig6.606170NoYes4010
2x64Lig5.8232YesYes3010
3x223x263.787172NoNo3522
3x22E24.357082NoYes3521
3x253x294.802062YesYes9421
3x25E26.517422YesYes9521
3x26E25.270282NoYes5521
3x29E24.390672YesYes4511
3x29Lig3.346812YesYes4010
3x32Lig4.081530NoYes5010
3x33Lig7.602942NoYes4010
3x366x483.343560NoYes6812
3x36Lig4.493750NoYes6010
3x375x432.750110YesYes6521
4x594x602.633942NoNo5522
4x59E22.781582NoYes5521
4x60E24.229782NoYes5521
4x605x398.37022NoNo5722
5x36E211.83892NoYes4521
5x39E27.727032NoYes7521
E2E251.20312YesYes5511
E2E38.904612YesYes5112
6x58E26.8590NoYes3521
7x34E25.922392NoYes4511
E2Lig11.91532YesYes5010
5x395x435.398472NoYes7521
5x406x553.323082NoNo5611
5x406x594.069752NoNo5312
5x43Lig5.741172YesYes5010
6x516x554.834922NoNo6611
6x547x343.068780NoNo4421
6x55Lig2.733032NoYes6010
7x34Lig2.77052NoYes4010
7x38Lig4.980440NoYes5010
3x335x432.834642NoYes4511
5x40Lig2.714282NoYes5010
6x51Lig2.852312NoYes6010
1x432x575.116830NoYes7621
E2E2x514.640832YesNo5012
7x35E23.858672YesYes4521
E3E38.210922YesYes1122
7x42Lig3.0662NoYes6010
E2E2x523.707422YesNo5012
2x647x352.72552YesYes3412
3x294x654.353752YesNo4012
4x64E25.379752NoYes0521
4x65E2x524.6620NoNo0022
5x38E22.594560NoYes4521
3x334x572.574692NoNo4712
E1x49E22.3282NoYes0521
2x54Lig2.024670NoYes8010
1x362x641.865580NoYes5321
5x32E20.999752NoYes0521
2x64E1x470.3403332YesNo3012
2x642x670.2386672YesNo3012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
68.42Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
66.67Single7YITNalfurafine7YIT-κ-Nalfurafine
66.67Single8WU1KCA8WU1-CB1-KCA-Arrestin1
66.67Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
64.71Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
64.71Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
64.71Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
63.16Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
62.50Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
62.50Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
61.11Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
61.11Single8E0GBU728E0G-μ-BU72
60.00Single5ZTYAM102575ZTY-CB2-AM10257
60.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
58.82Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
58.82Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
58.82Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
57.89Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
57.89Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
57.89Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
57.89Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
57.14Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
57.14Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
57.14Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
56.25Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
55.56Single5C1MBU725C1M-μ-BU72
55.56Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
55.56Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
55.56Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
55.56Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
55.56Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
55.56Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
55.56Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
55.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
55.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
55.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
54.55Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
53.85Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
52.94Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
52.94Single4ZJCSB-6740424ZJC-OX1-SB-674042
52.94Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
52.94Single6TPGEMPA6TPG-OX2-EMPA
52.94Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
52.94Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
52.94Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
52.63Single4RWADIPP-NH24RWA-δ-DIPP-NH2
52.63Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
52.63Single5XR8AM8415XR8-CB1-AM841
52.63Single5XRAAM115425XRA-CB1-AM11542
52.63Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
52.63Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
52.63Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
52.63Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
52.63Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
52.63Consensusa2_onOrthosteric Liganda2a_on a2b_on
52.63Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
52.63Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
52.63Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
52.63Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
52.63Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
52.38Single3NY9PubChem 9131033NY9-β2-PubChem 913103
52.38Single4UG2CGS216804UG2-A2A-CGS21680
52.38Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
52.38Consensuslpl_offOrthosteric Ligands1p_off lpa_off
52.38Consensuslpl_onOrthosteric Ligands1p_on lpa_on
52.38Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
52.17Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
52.17Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
50.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
50.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
50.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
50.00Single7UL4Alvimopan7UL4-μ-Alvimopan
50.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
50.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
50.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
50.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
50.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
50.00Consensusgi_hcarOrthosteric Ligandgi_hca
50.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
50.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
50.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
48.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
47.83Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
47.83Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
47.62Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.62Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
47.62Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
47.62Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
47.62Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
47.62Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
47.62Consensusendothelin_offOrthosteric Ligandetb_off
47.62Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
47.62Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.62Consensusorexin_onOrthosteric Ligandox2_on
47.62Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
47.37Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
47.37Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
47.37Single5WQCEMPA5WQC-OX2-EMPA
47.37Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
47.37Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
47.37Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
47.37Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
47.37Single6TP6Filorexant6TP6-OX1-Filorexant
47.37Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
47.37Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
47.37Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
47.37Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
47.37Single7WC6LSD7WC6-5-HT2A-LSD
47.37Single7XKAEpinephrine7XKA-β2-Epinephrine
47.37Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.37Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
47.37Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
47.06Single5WS3EMPA5WS3-OX2-EMPA
47.06Single6AKXA4R6AKX-CCR5-A4R
47.06Single6B73PubChem 1319551386B73-κ-PubChem 131955138
47.06Single6TODEMPA6TOD-OX1-EMPA-Na
47.06Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
47.06Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
47.06Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
47.06Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
47.06Consensusorexin_offOrthosteric Ligandox2_off ox1_off
46.43Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
46.15Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
45.83Single6PT2KGCHM076PT2-δ-KGCHM07
45.83Single6W25SHU91196W25-MC4-SHU9119-Ca
45.83Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
45.83Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
45.83Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
45.45Single6PT3DPI-2876PT3-δ-DPI-287
45.45Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
45.45Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
45.45Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
45.45Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
45.45Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
45.00Single2YDVNECA2YDV-A2A-NECA
45.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
45.00Single4DJHJDTic4DJH-κ-JDTic
45.00Single4UHRCGS216804UHR-A2A-CGS21680
45.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
45.00Single5G53NECA5G53-A2A-NECA-Gs
45.00Single5X93K-87945X93-ETB-K-8794
45.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
45.00Single6J21Aprepitant6J21-NK1-Aprepitant
45.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
45.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
45.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
45.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
45.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
45.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
45.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
45.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
45.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
45.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
45.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
45.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
45.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
45.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
45.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
45.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
45.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
45.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
45.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
45.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
45.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
45.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
45.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
44.44Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
44.44Single4MBSMaraviroc4MBS-CCR5-Maraviroc
44.44Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
44.44Single6PS4ICI 118-5516PS4-β2-ICI 118-551
44.44Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
44.44Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
44.44Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
44.44Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
44.44Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
44.44Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
44.44Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
44.44Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GGQEpinephrine8GGQ-β2-Epinephrine
44.44Single8GGTEpinephrine8GGT-β2-Epinephrine
44.44Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
44.44Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
44.44Single8K5CAcipimox8K5C-HCA2-Acipimox
44.44Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
44.44Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
44.44Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
44.44Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
44.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
44.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
44.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
43.48Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
43.48Single7QA8Peptide7QA8-STE2-Peptide
43.48Single7QA8Peptide7QA8-STE2-Peptide
43.48Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
43.48Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
43.48Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
43.48Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
43.48Consensusclass-d_offOrthosteric Ligandste2_off
43.48Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
43.48Consensussst_onOrthosteric Ligandsst2_on sst4_on
42.86Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
42.86Single4LDEBI1671074LDE-β2-BI167107
42.86Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.86Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
42.86Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
42.86Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
42.86Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
42.86Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.86Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
42.86Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
42.86Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
42.86Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
42.86Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
42.86Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
42.86Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
42.86Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
42.86Single8JJ8Formoterol8JJ8-β2-Formoterol
42.86Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
42.86Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
42.86Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
42.86Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
42.86Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
42.86Consensusgs_steroidOrthosteric Ligandgs_bileacid
42.86Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
42.86Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
42.86Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
42.31Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
42.31Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
42.31Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
42.11Single2Y04Salbutamol2Y04-β1-Salbutamol
42.11Single3NY8ICI 118-5513NY8-β2-ICI 118-551
42.11Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
42.11Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
42.11Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
42.11Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
42.11Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
42.11Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
42.11Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
42.11Single6PS1Timolol6PS1-β2-Timolol
42.11Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
42.11Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
42.11Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
42.11Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
42.11Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
42.11Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
42.11Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
42.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
42.11Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
42.11Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
42.11Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
42.11Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
42.11Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
42.11Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
42.11Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GGJEpinephrine8GGJ-β2-Epinephrine
42.11Single8GGNEpinephrine8GGN-β2-Epinephrine
42.11Single8GGOEpinephrine8GGO-β2-Epinephrine
42.11Single8GGUEpinephrine8GGU-β2-Epinephrine
42.11Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
42.11Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
42.11Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
42.11Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
42.11Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
42.11Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
42.11Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
42.11Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
42.11Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
42.11Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
42.11Consensustar_onOrthosteric Ligandta1_on
41.67Single3QAKUK-4320973QAK-A2A-UK-432097
41.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
41.67Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
41.67Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
41.67Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
41.67Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
41.18Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
41.18Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
41.18Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
41.18Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
41.18Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GH1Epinephrine8GH1-β2-Epinephrine
41.18Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
41.18Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
41.18Single8K5BNiacin8K5B-HCA2-Niacin
41.18Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
40.91Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
40.91Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
40.91Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.91Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
40.91Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
40.91Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
40.91Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
40.91Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
40.91Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
40.91Single7UM4AS26747237UM4-5-HT5A-AS2674723
40.91Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
40.91Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
40.91Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
40.91Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.91Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
40.91Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
40.91Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.91Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
40.91Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
40.91Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
40.91Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
40.91Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
40.91Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
40.91Consensussteroid_onOrthosteric Ligandbileacid_on
40.74Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
40.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
40.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
40.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
40.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
40.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
40.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
40.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
40.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
40.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
40.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
40.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
40.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
40.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
40.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
40.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
40.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
40.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
40.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
40.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
40.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
40.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
40.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
40.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
40.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
40.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
40.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
40.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
40.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
40.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
40.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
40.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
40.00Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
40.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
39.29Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
39.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
39.13Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
39.13Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
39.13Single7SK9CCX6627SK9-ACKR3-CCX662
39.13Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
39.13Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
39.13Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
39.13Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Single8X5YAstemizole8X5Y-H1-Astemizole
39.13Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
39.13Consensusclass-d_offOrthosteric Ligandste2_off
39.13Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
39.13Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
38.89Single3PWHZM2413853PWH-A2A-ZM241385
38.89Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
38.89Single4S0VSuvorexant4S0V-OX2-Suvorexant
38.89Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.89Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
38.89Single6TPJSuvorexant6TPJ-OX2-Suvorexant
38.89Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
38.89Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
38.89Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.89Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
38.89Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
38.89Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
38.89Single7XRRLemborexant7XRR-OX2-Lemborexant
38.89Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
38.89Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGVEpinephrine8GGV-β2-Epinephrine
38.89Single8GGWEpinephrine8GGW-β2-Epinephrine
38.89Single8GGXEpinephrine8GGX-β2-Epinephrine
38.89Single8GH0Epinephrine8GH0-β2-Epinephrine
38.89Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
38.89Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
38.89Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Consensusalpha1_onOrthosteric Ligandalpha1a_on
38.89Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
38.10Single3P0GBI1671073P0G-β2-BI167107
38.10Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
38.10Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
38.10Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
38.10Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
38.10Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
38.10Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
38.10Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
38.10Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
38.10Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
38.10Single7TUYGSK682753A7TUY-GPR183-GSK682753A
38.10Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
38.10Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
38.10Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
38.10Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.10Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.10Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
38.10Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
38.10Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.10Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
38.10Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
38.10Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
38.10Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
38.10Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
38.10Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
38.10Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
38.10Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
38.10Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
38.10Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
38.10Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
38.10Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
38.10Consensuscck_onOrthosteric Ligandccka_on cckb_on
38.10Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
38.10Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
38.10Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
38.10Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
38.10Consensushistamine_offOrthosteric Ligandh1_off
38.10Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.10Consensuslpa_offOrthosteric Ligandlpa1_off
38.10Consensuslpa_onOrthosteric Ligandlpa1_on
38.10Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
38.10Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
37.93Single6IGLIRL16206IGL-ETB-IRL1620
37.93Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
37.93Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
37.50Single4IARErgotamine4IAR-5-HT1B-Ergotamine
37.50Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
37.50Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
37.50Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
37.50Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
37.50Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
37.50Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
37.50Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
37.50Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
37.04Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
37.04Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
37.04Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
37.04Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
37.04Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
37.04Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
37.04Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
36.84Single2YDOAdenosine2YDO-A2A-Adenosine
36.84Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
36.84Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
36.84Single6IQLL7458706IQL-D4-L745870
36.84Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
36.84Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
36.84Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
36.84Single6TP3Nemorexant6TP3-OX1-Nemorexant
36.84Single6TPNHTL66416TPN-OX2-HTL6641
36.84Single6V9SGTPL114036V9S-OX1-GTPL11403
36.84Single6VI4JDTic6VI4-κ-JDTic
36.84Single7AROLUF58337ARO-A2A-LUF5833-Na
36.84Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
36.84Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
36.84Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
36.84Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
36.84Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
36.84Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
36.84Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
36.84Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
36.84Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8GGIEpinephrine8GGI-β2-Epinephrine
36.84Single8GGKEpinephrine8GGK-β2-Epinephrine
36.84Single8GGMEpinephrine8GGM-β2-Epinephrine
36.84Single8GGPEpinephrine8GGP-β2-Epinephrine
36.84Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
36.84Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
36.84Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
36.84Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
36.84Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
36.84Consensus5ht5_onOrthosteric Ligand5ht5a_on
36.84Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
36.84Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
36.84Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
36.84Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
36.84Consensushca_onOrthosteric Ligandhca2_on hca3_on
36.84Consensushcar_onOrthosteric Ligandhca_on
36.84Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
36.84Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
36.84Consensuss1p_offOrthosteric Ligands1p1_off
36.67Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
36.67Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
36.36Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
36.36Single4AMIBucindolol4AMI-β1-Bucindolol
36.36Single6A93Risperidone6A93-5-HT2A-Risperidone
36.36Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
36.36Single6HLPNetupitant6HLP-NK1-Netupitant
36.36Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
36.36Single6MXTSalmeterol6MXT-β2-Salmeterol
36.36Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
36.36Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
36.36Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
36.36Single6ZG4HTL00099366ZG4-M1-HTL0009936
36.36Single7DFPSpiperone7DFP-D2-Spiperone
36.36Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
36.36Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
36.36Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
36.36Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
36.36Single8JJLOlodaterol8JJL-β2-Olodaterol
36.36Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
36.36Single8JWZAB9288JWZ-A2A-AB928-Na
36.36Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
36.36Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
36.36Consensusgi_class-fOther Ligandgi_frizzled
36.36Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
36.36Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
36.36Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
36.36Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
36.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
36.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
36.00Single6HLOAprepitant6HLO-NK1-Aprepitant
36.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
36.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
36.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
36.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
36.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
36.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
36.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
36.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
36.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
35.71Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
35.71Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
35.71Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
35.71Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
35.29Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.29Single8GGREpinephrine8GGR-β2-Epinephrine
35.29Single8GGZEpinephrine8GGZ-β2-Epinephrine
35.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
35.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
35.29Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
35.29Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
35.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
35.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
35.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
35.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
35.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
35.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
35.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
35.00Single4YAYZD-71554YAY-AT1-ZD-7155
35.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
35.00Single5TGZAM65385TGZ-CB1-AM6538
35.00Single5UENDU1725UEN-A1-DU172
35.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
35.00Single6H7MSalbutamol6H7M-β1-Salbutamol
35.00Single6IIVDaltroban6IIV-TP-Daltroban
35.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
35.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
35.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
35.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
35.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
35.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
35.00Single7BU7BI1671077BU7-β1-BI167107
35.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
35.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
35.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
35.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
35.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
35.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
35.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
35.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
35.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
35.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
35.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
35.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
35.00Single8CU6LJ-45178CU6-A2A-LJ-4517
35.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
35.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
35.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
35.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
35.00Single8JJOAlprenolol8JJO-β2-Alprenolol
35.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Single8K5DGSK2560738K5D-HCA2-GSK256073
35.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
35.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
35.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Single8X64Desloratadine8X64-H1-Desloratadine
35.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
35.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
35.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
35.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
35.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
35.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
35.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
35.00Consensusblt_onOrthosteric Ligandblt1_on
35.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
35.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
35.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
35.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
35.00Consensusleuko_onOrthosteric Ligandblt_on
35.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
35.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
35.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
34.78Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
34.78Single6H7LDobutamine6H7L-β1-Dobutamine
34.78Single6IBLArformoterol6IBL-β1-Arformoterol
34.78Single7EZCUKA7EZC-A2A-UKA
34.78Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
34.78Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
34.78Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
34.78Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
34.78Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
34.78Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
34.78Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
34.78Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
34.78Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single5WF5UK-4320975WF5-A2A-UK-432097
34.62Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
34.62Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
34.62Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
34.62Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
34.62Consensusangiotensin_onOrthosteric Ligandat1_on
34.62Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
34.62Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
34.62Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
34.48Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
34.48Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single3PBLEticlopride3PBL-D3-Eticlopride
33.33Single5N2SPSB365N2S-A1-PSB36
33.33Single5NM2ZM2413855NM2-A2A-ZM241385-Na
33.33Single5TVNLSD5TVN-5-HT2B-LSD
33.33Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
33.33Single5WF6UK-4320975WF6-A2A-UK-432097
33.33Single5WIUNemonapride5WIU-D4-Nemonapride
33.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
33.33Single5XPRBosentan5XPR-ETB-Bosentan
33.33Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
33.33Single6E67BI1671076E67-β2-BI167107-Gs (fused)
33.33Single6HLLCP999946HLL-NK1-CP99994
33.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
33.33Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
33.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
33.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
33.33Single6PS6Timolol6PS6-β2-Timolol
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
33.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
33.33Single7C4SS1P7C4S-S1P3-S1P
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
33.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
33.33Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
33.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
33.33Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SRQLSD7SRQ-5-HT2B-LSD
33.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7XN9L-054,5227XN9-SST2-L-054,522
33.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
33.33Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
33.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
33.33Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
33.33Single8GGSEpinephrine8GGS-β2-Epinephrine
33.33Single8GGYEpinephrine8GGY-β2-Epinephrine
33.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
33.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
33.33Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
33.33Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
33.33Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
33.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
33.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
33.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
33.33Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
33.33Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
33.33Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
33.33Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
33.33Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
33.33Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
33.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.26Single5GLHEndothelin-15GLH-ETB-Endothelin-1
32.26Single6IGKEndothelin-36IGK-ETB-Endothelin-3
32.14Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
32.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
32.14Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
32.14Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
32.14Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
32.14Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
32.00Single4XT1Fractalkine4XT1-US28-Fractalkine
32.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
32.00Single7F8XNN90567F8X-CCKA-NN9056
32.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
32.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
32.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
32.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
32.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
32.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
32.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
32.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
32.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
32.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
31.82Single4U15Tiotropium4U15-M3-Tiotropium
31.82Single5V54Methiothepin5V54-5-HT1B-Methiothepin
31.82Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
31.82Single6E59L-7607356E59-NK1-L-760735
31.82Single6J20Aprepitant6J20-NK1-Aprepitant
31.82Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
31.82Single6OL9Tiotropium6OL9-M5-Tiotropium
31.82Single6WGTLSD6WGT-5-HT2A-LSD
31.82Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
31.82Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
31.82Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
31.82Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
31.82Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
31.82Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
31.82Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
31.82Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.82Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
31.82Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
31.82Consensus5ht1_offOrthosteric Ligand5ht1b_off
31.82Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
31.82Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.82Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
31.82Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
31.82Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
31.82Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
31.82Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
31.82Consensusrelaxin_onOrthosteric Ligandrxfp4_on
31.58Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
31.58Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
31.58Single5DHHSB-6121115DHH-NOP-SB-612111
31.58Single5K2DZM2413855K2D-A2A-ZM241385
31.58Single5ZKQABT-4915ZKQ-PAF-ABT-491
31.58Single6JZHZM2413856JZH-A2A-ZM241385-Na
31.58Single6KUXRS-799486KUX-α2a-RS-79948
31.58Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
31.58Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
31.58Single6PS7ZM2413856PS7-A2A-ZM241385-Na
31.58Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
31.58Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
31.58Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
31.58Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
31.58Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
31.58Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
31.58Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
31.58Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
31.58Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
31.58Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
31.58Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GNGIstradefylline8GNG-A2A-Istradefylline
31.58Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
31.58Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
31.58Single8IHKAcifran8IHK-HCA3-Acifran
31.58Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
31.58Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8IWESpermidine8IWE-TAAR9-Spermidine
31.58Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
31.58Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
31.58Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
31.58Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
31.58Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
31.58Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
31.58Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
31.58Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
31.58Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
31.58Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
31.58Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Consensusmglu_onOther Ligandmglu2_on mglu4_on
31.03Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
31.03Consensusclass-d_onOrthosteric Ligandste2_on
31.03Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
31.03Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
30.77Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.77Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
30.77Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
30.77Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
30.56Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
30.43Single4N4WSANT-14N4W-SMO-SANT-1
30.43Single5CXVTiotropium5CXV-M1-Tiotropium
30.43Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
30.43Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
30.43Single6CM4Risperidone6CM4-D2-Risperidone
30.43Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
30.43Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
30.43Single6IIURamatroban6IIU-TP-Ramatroban
30.43Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
30.43Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.43Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.43Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
30.43Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
30.43Single7K15MKD0467K15-BLT1-MKD046-Na
30.43Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
30.43Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
30.43Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
30.43Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
30.43Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
30.43Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
30.43Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
30.43Consensusblt_offOrthosteric Ligandblt1_off
30.43Consensusclass-b2_onOrthosteric Ligandadgrg_on
30.43Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
30.43Consensusdp_offOrthosteric Liganddp2_off
30.43Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
30.43Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
30.43Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
30.30Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
30.00Single3REYPubChem 56973REY-A2A-PubChem 5697
30.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
30.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
30.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
30.00Single5JTBZM2413855JTB-A2A-ZM241385
30.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
30.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
30.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
30.00Single6AQFZM2413856AQF-A2A-ZM241385
30.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
30.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
30.00Single6MH8ZM2413856MH8-A2A-ZM241385
30.00Single6TPKRetosiban6TPK-OT-Retosiban
30.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
30.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
30.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
30.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
30.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
30.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
30.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
30.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
30.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
30.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
30.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8GGLEpinephrine8GGL-β2-Epinephrine
30.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
30.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
30.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
30.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
30.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
30.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
30.00Consensusgi_class-dOrthosteric Ligandgi_ste
30.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
30.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
30.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
29.63Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
29.63Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
29.63Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
29.63Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single3RFMCaffeine3RFM-A2A-Caffeine
29.41Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
29.41Single8A2OTheophylline8A2O-A2A-Theophylline-Na
29.41Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
29.41Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
29.41Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
29.41Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
29.17Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
29.17Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
29.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
29.17Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
29.17Single6K1QIRL25006K1Q-ETB-IRL2500
29.17Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
29.17Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
29.17Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
29.17Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
29.17Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
29.17Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
29.17Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
29.17Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
29.03Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
29.03Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single2Y01Dobutamine2Y01-β1-Dobutamine
28.57Single2Y02Carmoterol2Y02-β1-Carmoterol
28.57Single3EMLZM2413853EML-A2A-ZM241385
28.57Single4EIYZM2413854EIY-A2A-ZM241385-Na
28.57Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
28.57Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
28.57Single5IU8Q274563475IU8-A2A-Q27456347-Na
28.57Single5K2AZM2413855K2A-A2A-ZM241385-Na
28.57Single5OLGZM2413855OLG-A2A-ZM241385-Na
28.57Single5VRAZM2413855VRA-A2A-ZM241385-Na
28.57Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
28.57Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
28.57Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
28.57Single6DRXLisuride6DRX-5-HT2B-Lisuride
28.57Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
28.57Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
28.57Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
28.57Single6GPSMK08126GPS-CCR2-MK0812
28.57Single6LPJZM2413856LPJ-A2A-ZM241385-Na
28.57Single6LPKZM2413856LPK-A2A-ZM241385-Na
28.57Single6S0LZM2413856S0L-A2A-ZM241385
28.57Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
28.57Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
28.57Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
28.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
28.57Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
28.57Single7PYRPSB-21157PYR-A2A-PSB-2115
28.57Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
28.57Single7WC7Lisuride7WC7-5-HT2A-Lisuride
28.57Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
28.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
28.57Single8X63Mepyramine8X63-H1-Mepyramine
28.57Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
28.57Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
28.57Consensusa2_offOrthosteric Liganda2a_off
28.57Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
28.57Consensuscck_offOrthosteric Ligandccka_off
28.57Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
28.57Consensusclass-d_onOrthosteric Ligandste2_on
28.57Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
28.57Consensusgi_class-dOrthosteric Ligandgi_ste
28.57Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
28.57Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
28.57Consensushcar_offOrthosteric Ligandsuccinate_off
28.57Consensushistamine_onOrthosteric Ligandh1_on h4_on
28.57Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
28.57Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
28.57Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
28.57Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
28.57Consensuspth_onOrthosteric Ligandpth1_on pth2_on
28.57Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
28.57Consensustachykinin_offOrthosteric Ligandnk1_off
28.12Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
28.00Single5EE7MK08935EE7-Glucagon-MK0893
28.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
28.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
28.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
28.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
28.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
28.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
28.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
28.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
28.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
28.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
28.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
27.78Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
27.78Single3OE6IT1t3OE6-CXCR4-IT1t
27.78Single3UZAGTPL92363UZA-A2A-GTPL9236
27.78Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
27.78Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
27.78Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
27.78Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
27.59Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
27.59Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
27.59Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
27.59Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
27.59Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
27.59Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single2Y00Dobutamine2Y00-β1-Dobutamine
27.27Single4NTJAZD12834NTJ-P2Y12-AZD1283
27.27Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
27.27Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.27Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
27.27Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
27.27Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
27.27Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
27.27Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.27Single6GPXMK08126GPX-CCR2-MK0812
27.27Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
27.27Single6LPLZM2413856LPL-A2A-ZM241385-Na
27.27Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
27.27Single6S0QZM2413856S0Q-A2A-ZM241385
27.27Single6WQAZM2413856WQA-A2A-ZM241385-Na
27.27Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
27.27Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.27Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
27.27Single7RM5ZM2413857RM5-A2A-ZM241385-Na
27.27Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.27Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
27.27Single8FYNZM2413858FYN-A2A-ZM241385-Na
27.27Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
27.27Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.27Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Single8QOTNanobody E8QOT-μ-Nanobody E
27.27Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
27.27Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
27.27Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
27.27Consensusep_offOrthosteric Ligandep4_off
27.27Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Consensusglp_onOrthosteric Ligandglp1_on glp2_on
27.27Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.27Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.27Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
27.27Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.03Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
26.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.92Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
26.92Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.92Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
26.92Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
26.67Single4XT3Fractalkine4XT3-US28-Fractalkine
26.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.67Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
26.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
26.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
26.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.32Single3OE9IT1t3OE9-CXCR4-IT1t
26.32Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.32Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
26.32Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
26.32Single6TP4ACT-4622066TP4-OX1-ACT-462206
26.32Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.32Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
26.32Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
26.32Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
26.32Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
26.32Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.32Consensusclass-t_onOrthosteric Ligandtaste2_on
26.32Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Consensusgs_class-tOrthosteric Ligandgs_taste
26.32Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
26.32Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
26.09Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
26.09Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
26.09Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
26.09Single5TZR-5TZR-FFA1 (GPR40)-MK8666
26.09Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
26.09Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
26.09Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
26.09Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.09Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
26.09Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.09Single7PX4PSB-21137PX4-A2A-PSB-2113
26.09Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
26.09Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
26.09Single7W41PD1762527W41-BB2-PD176252
26.09Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
26.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
26.09Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
26.09Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
26.09Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.09Consensusbombesin_offOrthosteric Ligandbb2_off
26.09Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.09Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
26.09Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
26.09Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.93Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
25.81Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
25.81Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusgo_class-b1Orthosteric Ligandgo_crf
25.81Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.71Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.71Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
25.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
25.71Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
25.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
25.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
25.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
25.00Single3ODUIT1t3ODU-CXCR4-IT1t
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
25.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5X33BIIL2605X33-BLT1-BIIL260
25.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
25.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
25.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
25.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
25.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
25.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
25.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
25.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
25.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
25.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
25.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
25.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
25.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
25.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
25.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
25.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
25.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgt_class-aOrthosteric Ligandgt_opsin
25.00Consensusgt_opsinOrthosteric Ligandgt_sensory
25.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
25.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
25.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
24.24Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
24.24Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
24.24Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
24.14Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
24.14Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.14Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.14Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
24.14Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
24.14Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
24.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
24.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
24.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
24.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
24.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
24.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
24.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
24.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.81Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
23.81Single3RZECidoxepin3RZE-H1-Cidoxepin
23.81Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
23.81Single5K2BZM2413855K2B-A2A-ZM241385-Na
23.81Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
23.81Single5UVIZM2413855UVI-A2A-ZM241385
23.81Single6A94Zotepine6A94-5-HT2A-Zotepine
23.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.81Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
23.81Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
23.81Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
23.81Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
23.81Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.81Single7T32ZM2413857T32-A2A-ZM241385
23.81Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
23.81Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.81Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
23.81Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
23.81Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
23.81Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
23.81Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
23.81Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
23.81Single8K2WAMG4878K2W-CXCR3-AMG487
23.81Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
23.81Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
23.81Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
23.81Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
23.81Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
23.81Consensusgnrh_offOrthosteric Ligandgnrh1_off
23.81Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
23.81Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
23.81Consensussensory_offOrthosteric Ligandopsin_off
23.53Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
23.53Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
23.53Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.53Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
23.53Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
23.53Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
23.53Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8PWNTheophylline8PWN-A2A-Theophylline
23.53Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
23.33Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
23.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
23.08Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
23.08Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusgs_class-b2Orthosteric Ligandgs_adgr
23.08Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.86Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
22.86Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
22.86Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
22.86Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
22.73Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
22.73Single4DAJTiotropium4DAJ-M3-Tiotropium
22.73Single4MQSIperoxo4MQS-M2-Iperoxo
22.73Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
22.73Single4U14Tiotropium4U14-M3-Tiotropium
22.73Single5DSGTiotropium5DSG-M4-Tiotropium
22.73Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
22.73Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
22.73Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
22.73Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
22.73Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
22.73Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.73Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
22.73Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
22.73Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.73Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.73Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
22.73Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.58Single6FJ3PTH6FJ3-PTH1-PTH
22.58Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
22.58Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
22.58Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
22.22Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
22.22Single6TQ9SB-4081246TQ9-OX1-SB-408124
22.22Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
22.22Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
22.22Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
22.22Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
22.22Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
22.22Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
22.22Consensussensory_onOrthosteric Ligandopsin_on
21.88Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
21.88Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
21.88Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
21.88Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
21.88Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
21.88Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.74Single5CGCHTL142425CGC-mGlu5-HTL14242
21.74Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
21.74Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
21.74Single6LUQHaloperidol6LUQ-D2-Haloperidol
21.74Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.74Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
21.74Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
21.74Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
21.74Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
21.74Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
21.74Single8EA0Iperoxo8EA0-M3-Iperoxo
21.74Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
21.74Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
21.62Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
21.43Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single6LMLGlucagon6LML-Glucagon-Glucagon
21.21Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
21.21Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
21.21Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.21Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.05Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
21.05Single3OE8IT1t3OE8-CXCR4-IT1t
21.05Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
21.05Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.05Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
21.05Single6ME5Agomelatine6ME5-MT1-Agomelatine
21.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.05Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
21.05Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
21.05Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.05Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
21.05Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.83Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.83Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.83Single5V56TC1145V56-SMO-TC114
20.83Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
20.83Single7EPENAM5637EPE-mGlu-NAM563
20.83Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.83Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.83Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.83Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
20.83Consensuschemerin_onOrthosteric Ligandcml1_on
20.83Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.83Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
20.83Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.69Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
20.69Single7XNACYN1548067XNA-SST2-CYN154806
20.69Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
20.69Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
20.69Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.51Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
20.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
20.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
20.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
20.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
20.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
20.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
20.00Single4XESNeurotensin4XES-NTS1-Neurotensin
20.00Single5L7IVismodegib5L7I-SMO-Vismodegib
20.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
20.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
20.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
20.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
20.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
20.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
20.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
20.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
20.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.00Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
20.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
20.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
20.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
20.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
20.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
20.00Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
20.00Consensusnts_onOrthosteric Ligandnts1_on
20.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.44Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single4BUONeurotensin4BUO-NTS1-Neurotensin
19.23Single5CGDHTL142425CGD-mGlu5-HTL14242
19.23Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
19.23Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
19.23Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
19.23Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
19.23Consensuscyslt_offOrthosteric Ligandcyslt2_off
19.23Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
19.05Single5U09Taranabant5U09-CB1-Taranabant
19.05Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
19.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
19.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
19.05Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
19.05Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
19.05Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
19.05Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
19.05Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
19.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
19.05Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
19.05Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
18.75Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.75Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
18.75Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
18.75Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
18.75Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
18.75Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7SK3CXCL127SK3-ACKR3-CXCL12
18.75Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.52Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.52Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
18.52Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
18.42Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
18.18Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
18.18Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
18.18Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.18Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
18.18Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
18.18Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
18.18Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.18Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
18.18Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
18.18Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
17.65Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single5MZPCaffeine5MZP-A2A-Caffeine-Na
17.65Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.39Single6D27CAY104716D27-DP2-CAY10471
17.39Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
17.39Single7F83PF-051904577F83-Ghrelin-PF-05190457
17.39Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
17.39Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
17.39Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
17.39Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
17.39Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.39Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
17.39Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.24Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
17.24Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
17.24Consensussst_offOrthosteric Ligandsst2_off
17.14Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.14Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.07Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
16.67Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
16.67Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
16.67Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
16.67Single6Z4SSR486926Z4S-NTS1-SR48692
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Consensusclass-c_onOther Ligandgabab_on mglu_on
16.22Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
16.13Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
16.13Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
16.00Single5V57TC1145V57-SMO-TC114
16.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.00Single6OS1TRV0266OS1-AT1-TRV026
16.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
16.00Single7P2L4YI7P2L-mGlu5-4YI
16.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
16.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
16.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
15.79Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
15.62Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.62Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.62Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.62Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.38Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
15.38Single6OS2TRV0266OS2-AT1-TRV026
15.38Single6YVRNTS8-136YVR-NTS1-NTS8-13
15.38Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
15.38Consensuschemokine_offOrthosteric Ligandcxcr_off
15.38Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
15.38Consensuscxcr_offOrthosteric Ligandcxcr4_off
15.38Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
15.38Consensusnts_offOrthosteric Ligandnts1_off
15.15Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.15Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.00Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
15.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
15.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
15.00Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
14.81Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
14.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.71Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
14.29Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.29Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
14.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
14.29Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.29Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.29Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Consensusgo_class-b2Orthosteric Ligandgo_adhesion
14.29Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
13.79Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
13.64Single4BWBNeurotensin4BWB-NTS1-Neurotensin
13.64Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
13.64Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
13.64Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
13.64Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
13.64Consensusclass-f_offOrthosteric Ligandsmo_off
13.64Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.33Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
13.33Single7SK5CXCL127SK5-ACKR3-CXCL12
13.33Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.16Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single6FFIMMPEP6FFI-mGlu5-MMPEP
13.04Single6ZINSR486926ZIN-NTS1-SR48692
13.04Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
13.04Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.04Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
13.04Single7VODCariprazine7VOD-5-HT2A-Cariprazine
13.04Single7VV6C48/807VV6-MRGPRX2-C48/80
13.04Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
13.04Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
13.04Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.04Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
13.04Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
12.50Single5T04Neurotensin5T04-NTS1-Neurotensin
12.50Single6FFHFenobam6FFH-mGlu5-Fenobam
12.50Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
12.50Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
12.12Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.76Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.54Single7F1TMIP-1a7F1T-CCR5-MIP-1a
11.54Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.54Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.43Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
11.36Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.11Single6W25Ca6W25-MC4-SHU9119-Ca
11.11Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
11.11Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.71Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
10.53Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.53Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.34Single6KNMJN241-96KNM-Apelin-JN241-9
10.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.00Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
10.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
10.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
9.52Single4XNWMRS25004XNW-P2Y1-MRS2500
9.52Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.52Single6LI0GTPL98046LI0-GPR52-GTPL9804
9.52Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
9.52Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
9.52Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
9.52Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
9.52Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
9.09Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
9.09Single7UL2SR486927UL2-NTS1-SR48692-Na
9.09Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
9.09Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.09Consensusgo_proteinOrthosteric Ligandgo_chemokine
9.09Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.09Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.70Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
8.70Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
8.70Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
8.70Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.70Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.70Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.41Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.52Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.25Single7SHEPI; PE7SHE-GPR158-PI; PE
6.25Consensusclass-c_offOther Ligandgabab_off mglu_off
5.26Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.26Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.26Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.26Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.13Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.13Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
4.76Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
4.76Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.76Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
4.76Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
4.76Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
4.76Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.55Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.55Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
4.55Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.55Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.35Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.17Single4QINSAG1.54QIN-SMO-SAG1.5
4.17Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.08Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.00Single8IYXYL-3658IYX-GPR34-YL-365
4.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.45Single7SHEPI; PE7SHE-GPR158-PI; PE
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.03Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.50Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.38Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.38Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.08Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
gi_cannabinoid 8GUS-CB2-HU-308-Gi1/&β;1/&γ;2
8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
6KPG-CB1-AM841-Gi1/&β;1/&γ;2
6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
gi_prostanoid 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2
8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8GCM-EP4-L902688-Gi1/&β;1/&γ;2
gi_ffa 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
gi_lpl 7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
gi_leukotriene 7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
Net Summary
Imin 2.6065
Number of Linked Nodes 1047
Number of Links 1211
Number of Hubs 166
Number of Links mediated by Hubs 684
Number of Communities 30
Number of Nodes involved in Communities 207
Number of Links involved in Communities 288
Path Summary
Number Of Nodes in MetaPath 94
Number Of Links MetaPath 93
Number of Shortest Paths 1529692
Length Of Smallest Path 3
Average Path Length 37.8892
Length of Longest Path 82
Minimum Path Strength 0.144708
Average Path Strength 4.93967
Maximum Path Strength 21.4152
Minimum Path Correlation 0.700583
Average Path Correlation 0.957608
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.25
Average % Of Corr. Nodes 31.3726
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.5206
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_class-agi_amine
gi_lipid
gi_melatonin
gi_peptide
gi_protein
gi_nucleotide
gi_hcar



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_lipid.zip



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