Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 1.67488502
2G.hns1.03 1.7823404
3G.S1.02 5.46012465
4G.H1.01 3.83635569
5G.S2.03 5.44985419
6G.S2.04 1.85669406
7G.S2.05 5.25944513
8G.S2.08 6.875214195
9G.S3.03 8.4545467
10G.S3.04 8.32868416
11G.S3.05 3.65228467
12G.S3.06 7.66493515
13G.s3h2.03 4.28572519
14G.H2.04 3.56142409
15G.H2.06 4.64345719
16G.H2.07 4.72462619
17G.H2.09 5.50484418
18G.h2s4.01 5.29831619
19G.s4h3.04 5.717426128
20G.s4h3.05 6.492414129
21G.H3.01 6.73394409
22G.H3.09 5.43889759
23G.H3.13 4.0172455
24G.H3.14 5.31733408
25G.H3.17 6.86112615
26G.H3.18 5.790144209
27G.S5.03 2.93919408
28G.S5.04 3.69836559
29G.S5.05 3.36896679
30G.S5.07 4.05521479
31G.HG.04 5.41474509
32G.HG.15 3.43071407
33G.hgh4.02 6.427925217
34G.hgh4.05 7.54925407
35G.H4.03 5.65616654
36G.H4.05 3.177964234
37G.H4.10 8.88994216
38G.H4.15 4.50029558
39G.h4s6.02 4.93693458
40G.S6.02 6.907565227
41G.S6.05 4.63905454
42G.s6h5.05 2.84558409
43G.H5.03 4.91691578
44G.H5.08 5.271375198
45G.H5.09 2.8145404
46G.H5.13 3.209787228
47G.H5.20 2.97351409
48G.H5.26 3.089246245
49b.1x1 1.60627604
50b.1x3 1.67306501
51b.1x4 1.98259408
52b.lhb1x3 2.43687502
53b.lhb1x6 3.719774253
54b.lhb1x9 2.72805403
55b.b1x3 3.99515447
56b.b1x4 3.09945547
57b.b1x6 6.90585449
58b.l1x3 7.86066649
59b.b2x1 7.4956518
60b.b2x5 6.92736507
61b.l3x2 4.8764549
62b.b4x3 3.95043487
63b.b4x6 7.82589749
64b.b5x2 4.90661407
65b.b5x3 6.29918649
66b.b5x5 4.953984185
67b.b5x7 5.53432407
68b.l5x1 4.13543588
69b.l5x2 2.71589406
70b.l5x5 7.50459619
71b.b6x5 3.83665686
72b.l6x5 5.777754134
73b.b7x1 5.953885134
74b.l7x2 3.77303519
75b.b8x4 5.67006586
76b.l8x5 2.0121503
77b.b9x4 5.20588509
78b.l9x3 6.913619
79b.l9x6 4.42232918
80b.b10x5 3.98838509
81b.l11x2 7.60142419
82b.b12x6 8.55129618
83b.b13x7 7.09944537
84b.l13x3 7.40992639
85b.l13x6 4.92065519
86b.l13x7 4.26454439
87b.b14x3 4.578435
88b.b15x1 6.35231539
89b.b15x2 5.50694416
90b.b15x3 4.57332439
91b.l15x1 4.52773417
92b.l15x2 4.69812539
93b.b16x4 10.1535436
94b.b16x5 4.23081405
95b.b16x6 8.27052638
96b.b17x5 6.62681417
97b.b17x7 8.08487418
98b.l17x3 7.3744719
99b.l17x6 5.7844519
100b.b18x3 4.40049418
101b.b18x5 5.07272405
102b.l18x1 4.967168116
103b.b19x2 6.07896616
104b.b19x4 5.79148418
105b.l19x2 5.60319519
106b.b20x4 10.2875518
107b.b20x6 6.5308616
108b.b20x7 3.36922409
109b.b21x1 7.6453517
110b.b21x7 6.29745505
111b.l21x2 4.55505404
112b.b22x5 4.783926117
113b.l22x5 5.845795259
114b.b23x6 6.261276157
115b.l23x1 7.71137406
116b.b24x4 6.371494156
117b.b24x6 5.729354158
118b.l24x3 4.18249405
119b.l25x3 8.311415109
120b.l25x4 3.24483405
121b.b26x3 3.81626406
122b.l26x1 6.384694267
123b.l27x1 10.1699719
124b.l27x2 7.405654109
125b.b28x3 4.10165447
126b.b28x4 6.72854106
127b.b28x6 7.872345109
128g.h1x1 0.972834402
129g.l1x4 4.45071408
130g.h2x11 6.750824116
131g.ctx3 4.606046279
132g.ctx6 2.62566406
133g.ctx16 4.00288748
134NT 11.6161825
1351x50 5.2871409
1361x60 2.15899407
137I1x50 4.85422408
1382x40 5.09294408
1392x42 3.51062408
1402x46 3.68936599
1412x50 5.44593599
1422x51 2.99327407
1432x57 4.3899506
1443x25 5.1445529
1453x29 5.11432424
1463x34 2.97784405
1473x49 4.01554409
1483x50 5.6572599
1493x51 5.505974168
1503x55 5.059544166
1514x56 3.221714285
152E2 8.533832525
1535x39 6.2127427
1545x43 4.56143405
1555x47 4.62842507
1565x50 3.30769407
1575x51 3.00189507
1585x58 4.56909509
1595x60 3.767075165
1605x64 3.652214166
161I3 2.357336223
1626x30 2.22833407
1636x32 2.845144248
1646x48 5.30287608
1656x55 4.12035426
1666x59 2.69925403
167E3 3.44272621
1687x49 4.77336499
1697x53 3.9703699
1708x50 2.52837408
1718x54 1.60916406
172Lig 5.556311420
173H.HA.19 0.1164294170
174H.HC.03 0.05691435170
175H.HC.07 0.09371434170
176H.HD.07 0.131400
177H.hdhe.01 0.104524600
178H.HE.05 0.0999429500
179H.HE.06 0.122643400
180H.HF.06 0.169929400
1814x65 2.76725420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 58.92273.10791NoNo085
2b.b3x1 b.l2x3 58.56125.21423NoNo058
3b.b3x1 b.b6x5 58.19953.9141NoYes056
4b.b2x3 b.b2x5 25.66062.81775NoYes067
5b.b26x2 b.b2x3 26.05225.58374NoNo076
6b.b26x1 b.b26x2 26.44532.82125NoNo097
7b.b26x1 b.l27x1 26.64265.89006NoYes099
8b.b2x1 b.l27x1 31.11417.41449YesYes189
9b.b2x1 b.l3x1 31.629613.2404YesNo189
10b.l3x1 b.l5x5 32.17236.92295NoYes199
11G.h2s4.01 b.l5x5 10.23899.94517YesYes199
12G.H2.07 G.h2s4.01 11.12843.3686YesYes199
13G.H2.04 G.H2.07 39.71714.26623YesYes099
14G.H2.04 G.H3.08 39.77964.22961YesNo099
15G.H3.08 G.S4.04 39.77454.75848NoNo099
16G.S4.04 G.S5.04 30.28283.00825NoYes599
17G.S5.04 G.S5.06 26.9713.51558YesNo098
18G.S5.06 G.S6.05 25.14257.48768NoYes084
19G.H4.03 G.S6.05 25.45213.55784YesYes544
20G.H4.03 G.HG.01 28.55696.86575YesNo045
21G.HG.01 G.s6h5.02 28.49222.9401NoNo057
22G.s6h5.02 G.s6h5.05 28.46022.19691NoYes079
23G.H5.03 G.s6h5.05 28.31123.09678YesYes089
24G.H5.03 G.S5.05 27.50423.46448YesYes789
25b.l5x5 b.l7x2 21.31734.63378YesYes199
26G.H2.07 b.l7x2 10.04753.55388YesYes199
27b.l7x2 b.l9x6 11.10972.76684YesYes198
28G.H2.06 b.l9x6 14.26074.11309YesYes198
29G.H2.06 b.l17x6 13.51626.79896YesYes199
30b.l25x6 b.l27x1 23.045619.615NoYes189
31G.S5.03 G.S5.05 26.513.13426YesYes089
32G.H5.10 G.S5.03 26.61723.43514NoYes068
33G.H5.10 G.S6.02 26.62485.34164NoYes067
34G.H5.13 G.S6.02 26.28417.51804YesYes2287
355x68 G.H5.13 27.03233.92286NoYes078
363x50 G.H5.25 86.96178.9606YesNo097
37G.H5.20 G.H5.25 88.38622.8171YesNo097
38G.H5.20 G.H5.26 95.35893.53334YesYes095
396x32 G.H5.26 96.46524.37257YesYes2485
406x32 7x58 97.91930.9YesNo080
417x58 7x59 98.46940.422NoNo000
427x59 G.H5.24 98.6140.422NoNo008
438x47 G.H5.24 98.82471.80279NoNo088
442x40 8x47 65.67263.46129YesNo088
452x40 I1x50 33.30829.02596YesYes088
46I1x49 I1x50 66.94662.89175NoYes068
47I1x49 b.l25x4 1003.68535NoYes065
48b.l25x4 b.l27x2 99.75973.70345YesYes059
49b.l25x3 b.l27x2 99.05147.75701YesYes1099
50b.b27x3 b.l25x3 62.96336.68426NoYes089
51b.b26x3 b.b27x3 27.67084.10375YesNo068
52b.b22x2 b.b26x3 27.92214.89377NoYes086
53b.b22x1 b.b22x2 27.85733.42442NoNo088
54b.b22x1 b.l23x1 27.79993.1709NoYes086
55b.l23x1 b.l25x6 24.714119.1416YesNo068
568x47 8x50 33.37172.9661NoYes088
578x50 I1x50 33.72092.76591YesYes088
582x40 8x49 32.98322.89509YesNo086
598x49 I1x49 33.15812.95869NoNo066
60b.b27x3 b.b28x6 36.08677.41032NoYes089
61b.b25x7 b.b28x6 70.904915.6344NoYes079
62b.b25x7 b.lhb1x11 71.49294.36764NoNo074
63b.lhb1x11 b.lhb1x9 71.14482.75829NoYes043
64b.b23x1 b.lhb1x9 60.46413.48904NoYes053
65b.b23x1 b.l22x1 59.56173.34053NoNo059
66b.l22x1 g.ctx3 59.04166.31092NoYes2799
67g.ctx3 g.ctx4 61.13644.38964YesNo097
68b.l26x5 g.ctx4 60.91595.90617NoNo057
69b.l26x5 g.ctx15 58.7084.64808NoNo059
70b.l4x2 g.ctx15 55.02678.72734NoNo049
71b.l2x5 b.l4x2 63.538323.6418NoNo054
72b.b28x4 b.l25x3 36.38678.89949YesYes1069
73b.b28x4 b.b28x6 35.97296.32275YesYes1069
74b.b2x4 b.b6x5 32.73153.18082NoYes066
75b.b10x4 b.b2x4 32.356611.2631NoNo066
76b.b10x2 b.b10x4 28.93912.99204NoNo066
77b.b10x2 b.b14x3 28.56374.9833NoYes065
78b.b14x3 b.b15x1 22.46414.71523YesYes359
79b.b15x1 b.b16x6 20.185511.3234YesYes398
80b.b16x4 b.b16x6 14.88138.75273YesYes368
81b.b16x4 b.b17x6 14.554110.0039YesNo067
82b.b17x6 g.l1x1 13.79471.694NoNo071
83g.h1x12 g.l1x1 13.41312.01491NoNo061
84g.h1x12 g.h1x9 11.123.16636NoNo066
85g.h1x5 g.h1x9 10.73732.16139NoNo066
86b.1x4 g.h1x5 10.35441.64495YesNo086
87b.l17x5 b.l17x6 14.4993.9076NoYes169
88b.l17x5 b.l19x2 14.37843.67888NoYes169
89b.l17x3 b.l19x2 13.23263.30382YesYes199
90b.l4x2 g.ctx16 16.21074.86673NoYes048
91b.b3x3 b.b6x5 21.94364.30361NoYes886
92b.b3x3 b.b4x3 21.57293.48892NoYes887
93b.b2x5 b.l4x1 15.48095.53573YesNo075
94b.l4x1 g.ctx16 15.27543.50457NoYes058
95b.l11x1 b.l9x6 16.76974.84444NoYes198
96b.b11x6 b.l11x1 17.91742.72253NoNo199
97b.b11x6 b.l9x3 16.962515.3904NoYes199
98b.b12x6 b.l9x3 16.226.53521YesYes189
99b.b12x6 b.b9x4 15.73814.934YesYes089
100b.b8x3 b.b9x4 14.72932.87927NoYes069
101b.b8x3 b.l12x1 12.04584.51218NoNo066
102b.b8x4 b.l8x10 15.09276.62255YesNo064
103b.l5x2 b.l8x10 13.94374.6043YesNo064
104b.l10x4 b.l12x1 10.83622.76953NoNo036
105b.b12x7 b.l10x4 10.56568.80908NoNo093
106b.b12x7 b.l12x3 10.43016.77104NoNo095
107b.b13x2 b.l12x3 10.29433.57523NoNo045
108b.l21x7 b.l23x1 14.41254.78253NoYes056
109b.l21x7 b.l23x2 13.95346.79056NoNo058
110b.b23x6 b.l23x2 13.03123.37234YesNo078
111b.b23x6 b.b24x6 10.26556.19814YesYes1578
112E2 Lig 27.75849.71317YesYes250
1133x36 Lig 39.38293.85032NoYes060
1143x36 6x48 39.86364.96179NoYes068
1156x48 7x45 40.8638.73414YesNo089
1167x45 7x49 41.90087.0219NoYes099
1172x46 7x49 21.14563.53256YesYes999
1182x46 7x53 31.06612.7941YesYes999
1193x50 7x53 56.31545.69547YesYes999
1203x43 7x49 21.03933.27886NoYes989
1213x43 7x53 21.29354.30816NoYes989
1225x43 Lig 28.34987.64829YesYes050
1235x43 5x47 43.23392.82329YesYes057
1245x47 5x51 44.60922.98593YesYes077
1255x51 5x55 46.59993.00418YesNo075
1265x55 6x41 46.84832.86047NoNo057
1275x58 6x41 47.10054.00397YesNo097
1283x50 5x58 38.66516.87596YesYes099
1295x39 E2 11.51798.06436YesYes275
1305x39 5x43 12.32314.18058YesYes075
1317x38 Lig 10.10586.65682NoYes050
1323x47 5x58 23.15045.63556NoYes099
1333x51 5x57 23.15865.88377YesNo086
1343x51 3x55 15.42526.98YesYes1686
1353x51 5x60 14.62816.16391YesYes1685
1365x64 5x68 27.31733.97118YesNo067
137H.hdhe.01 b.b13x2 10.15170.0642857YesNo004
138b.b21x7 b.b24x6 10.06758.18635YesYes058
1393x55 5x64 14.01764.84648YesYes1666
1405x60 5x64 13.84614.04988YesYes1656
141G.H2.07 b.l9x6 18.37273.881YesYes198
142b.lhb1x6 b.lhb1x9 10.09352.74495YesYes033
1433x47 5x57 22.92152.82758NoNo096
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT25.85062YesYes5511
E2NT28.23682YesYes5511
LigNT4.344872YesYes0501
2x573x323.15830YesNo6522
2x577x384.008070YesNo6521
2x603x284.725450NoNo4512
2x60Lig6.34820NoYes4010
2x64Lig5.407740NoYes3010
3x22E23.578682NoYes3521
3x253x297.941352YesYes9421
3x25E28.905492YesYes9521
3x26E25.983692NoYes5521
3x29Lig4.993832YesYes4010
3x33Lig10.65220NoYes4010
3x366x484.961790NoYes6812
3x36Lig3.850320NoYes6010
3x375x433.593570NoYes6521
4x60E24.837622NoYes5521
4x605x399.736132NoYes5722
E2E238.86652YesYes5511
5x36E29.303132NoYes4521
5x38E23.944362NoYes4521
6x58E29.903812NoYes3521
7x31E22.856520NoYes2521
7x34E25.47562NoYes4511
E2Lig9.713172YesYes5010
5x39E28.064362YesYes7521
5x365x383.047912NoNo4422
5x395x434.180582YesYes7521
5x406x555.744712NoYes5611
5x435x472.823290YesYes5712
5x43Lig7.648290YesYes5010
6x55Lig2.901942YesYes6010
7x34Lig6.115922NoYes4010
7x38Lig6.656820NoYes5010
2x603x324.219030NoNo4512
3x223x264.297162NoNo3522
3x253x283.17342YesNo9522
3x29E24.588092YesYes4511
3x335x392.869740NoYes4712
6x516x555.318362NoYes6611
5x40Lig3.217572NoYes5010
6x51Lig2.811512NoYes6010
5x476x484.335610YesYes7822
4x64E29.0132NoYes0521
4x65E24.4662YesYes0521
5x32E22.752NoYes0521
E2E2x523.0612YesNo5012
E3E33.127452YesYes1122
E1x501NT3.538180NoYes0521
7x35Lig3.1260NoYes4010
3x294x652.9342YesYes4012
4x65E2x523.172YesNo0022
4x59E22.620362NoYes5521
5x446x552.516380NoYes4621
6x547x342.50140NoNo4421
E2E32.485822YesYes5112
E2E2x512.3662YesNo5012
1x357x352.193910NoNo5421
5x37E22.126272NoYes4521
E1NT1.903430NoYes4521
E1x48NT1.6212NoYes0521
1x32NT1.583432NoYes5521
7x357x361.416910NoNo4412
E1x49E21.1962NoYes0521
4x66E20.1372NoYes0521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
73.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
73.33Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
72.22Consensuslpl_onOrthosteric Ligands1p_on lpa_on
72.22Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
70.59Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
68.75Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
65.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
64.71Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
64.71Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
64.71Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
63.16Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
63.16Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
63.16Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
62.50Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
62.50Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
61.11Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
61.11Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
61.11Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
61.11Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
60.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
58.82Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
58.82Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
58.82Single8E0GBU728E0G-μ-BU72
58.82Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
58.82Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
58.82Consensuslpa_onOrthosteric Ligandlpa1_on
58.82Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
57.89Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
57.89Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
57.89Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
57.89Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
57.89Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
57.14Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
56.25Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
56.25Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
55.56Single7YITNalfurafine7YIT-κ-Nalfurafine
55.56Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
55.56Consensuslpa_offOrthosteric Ligandlpa1_off
55.56Consensuslpl_offOrthosteric Ligands1p_off lpa_off
55.56Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
55.56Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
55.56Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
55.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
54.55Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
54.17Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
53.33Single3PWHZM-2413853PWH-A2A-ZM-241385
53.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
52.94Single5C1MBU725C1M-μ-BU72
52.94Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
52.94Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
52.94Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
52.94Single8TF5Oleic acid8TF5-GPR6-Oleic acid
52.94Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
52.94Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
52.94Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
52.94Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
52.63Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
52.63Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
52.63Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
52.63Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
52.63Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
52.38Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
52.38Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
52.38Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
52.38Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
52.38Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
52.17Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
52.17Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
50.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
50.00Single5ZTYAM102575ZTY-CB2-AM10257
50.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
50.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
50.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
50.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
50.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
50.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
50.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
50.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
50.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
50.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
50.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
50.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
50.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
50.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
50.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
50.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
50.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
50.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
50.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
50.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
50.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
50.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
50.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
50.00Consensusa2_onOrthosteric Liganda2b_on
50.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
50.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
50.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
50.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
50.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
50.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
50.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
50.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
50.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
50.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
50.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
50.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
50.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
50.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
48.15Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
48.15Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
48.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
48.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
48.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
48.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
47.83Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
47.83Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
47.83Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
47.62Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
47.62Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
47.62Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
47.62Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
47.62Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
47.62Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
47.37Single4RWADIPP-NH24RWA-δ-DIPP-NH2
47.37Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
47.37Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
47.37Single6KQICP559406KQI-CB1-CP55940-Org27569
47.37Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
47.37Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
47.37Single8JWY2-1188JWY-A2A-2-118
47.37Single8JWZAB9288JWZ-A2A-AB928-Na
47.37Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
47.37Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
47.37Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
47.37Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
47.37Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
47.37Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
47.37Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
47.06Single5UIGCmpd-15UIG-A2A-Cmpd-1
47.06Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
47.06Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
47.06Single7V3ZCP559407V3Z-CB1-CP55940
47.06Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
47.06Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
47.06Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
47.06Consensusa3_onOrthosteric Liganda3a_on
47.06Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
47.06Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
46.67Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
46.67Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
46.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
46.15Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
45.83Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
45.83Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
45.83Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
45.83Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
45.83Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
45.45Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
45.45Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
45.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
45.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
45.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
45.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
45.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
45.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
45.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
45.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
44.44Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
44.44Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
44.44Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
44.44Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
44.44Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
44.44Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
44.44Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
44.44Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
44.44Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
44.44Single8JXSPF-61428JXS-D1-PF-6142
44.44Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
44.44Consensusa3_on_gpOrthosteric Liganda3a_on_gp
44.44Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
44.44Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
44.44Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
44.44Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
44.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
43.75Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
43.75Single6AKXA4R6AKX-CCR5-A4R
43.75Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
43.75Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
43.75Consensusorexin_offOrthosteric Ligandox2_off ox1_off
43.75Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
43.75Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
43.48Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.48Consensusangiotensin_onOrthosteric Ligandat1_on
43.48Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
43.48Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
43.48Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
43.48Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
42.86Single3NY9ICI118-5513NY9-β2-ICI118-551
42.86Single4UG2CGS216804UG2-A2A-CGS21680
42.86Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
42.86Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
42.86Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
42.86Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
42.31Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
42.31Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
42.11Single3P0GBI1671073P0G-β2-BI167107
42.11Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
42.11Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
42.11Single5XR8AM8415XR8-CB1-AM841
42.11Single5XRAAM115425XRA-CB1-AM11542
42.11Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
42.11Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
42.11Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
42.11Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
42.11Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
42.11Single7TUYGSK682753A7TUY-GPR183-GSK682753A
42.11Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
42.11Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
42.11Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
42.11Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
42.11Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
42.11Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.11Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
42.11Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
42.11Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
42.11Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
42.11Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
42.11Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
42.11Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.11Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
42.11Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
42.11Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
41.67Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
41.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
41.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
41.67Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
41.67Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
41.67Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.67Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
41.67Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
41.67Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
41.67Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
41.67Consensusvasop-oxy_onOrthosteric Ligandv2_on
41.67Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
41.18Single3REYXAC3REY-A2A-XAC
41.18Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
41.18Single4MBSMaraviroc4MBS-CCR5-Maraviroc
41.18Single4ZJCSB-6740424ZJC-OX1-SB-674042
41.18Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
41.18Single5IUBQ274563445IUB-A2A-Q27456344-Na
41.18Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
41.18Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
41.18Single6AQFZM-2413856AQF-A2A-ZM-241385
41.18Single6TPGEMPA6TPG-OX2-EMPA
41.18Single7AROLUF58337ARO-A2A-LUF5833-Na
41.18Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
41.18Single8K5CAcipimox8K5C-HCA2-Acipimox
41.18Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
41.18Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
41.18Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
41.18Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
40.91Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.91Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
40.91Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
40.91Single8WDTphotoNECA8WDT-A2A-photoNECA
40.91Single8WKYPG-9348WKY-MC4-PG-934
40.91Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.91Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
40.91Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
40.74Single6IGLIRL16206IGL-ETB-IRL1620
40.74Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.74Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.74Consensusbradykinin_onOrthosteric Ligandbk2_on
40.74Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
40.74Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Single4LDEBI1671074LDE-β2-BI167107
40.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
40.00Single6MXTSalmeterol6MXT-β2-Salmeterol
40.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
40.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
40.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
40.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
40.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
40.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
40.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
40.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
40.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
40.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
40.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
40.00Single8JJ8Formoterol8JJ8-β2-Formoterol
40.00Single8JJLOlodaterol8JJL-β2-Olodaterol
40.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
40.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8XYIVUF106618XYI-CXCR3-VUF10661
40.00Single8ZRTET-18ZRT-ETB-ET-1
40.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
40.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
40.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
40.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
40.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
40.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
40.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
40.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusorexin_onOrthosteric Ligandox2_on
40.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
40.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.29Single5GLHEndothelin-15GLH-ETB-Endothelin-1
39.29Single6IGKEndothelin-36IGK-ETB-Endothelin-3
39.29Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
39.13Single3QAKUK-4320973QAK-A2A-UK-432097
39.13Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
39.13Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
39.13Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
39.13Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
39.13Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
39.13Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
39.13Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
39.13Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
39.13Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
39.13Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
39.13Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.89Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
38.89Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.89Single5IU8Q274563475IU8-A2A-Q27456347-Na
38.89Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
38.89Single5UENDU1725UEN-A1-DU172
38.89Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
38.89Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
38.89Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
38.89Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
38.89Single6TOTLemborexant6TOT-OX1-Lemborexant
38.89Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
38.89Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
38.89Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
38.89Single7PYRPSB-21157PYR-A2A-PSB-2115
38.89Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
38.89Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
38.89Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
38.89Single7UL4Alvimopan7UL4-μ-Alvimopan
38.89Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
38.89Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
38.89Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
38.89Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
38.89Single8RLNLUF58348RLN-A2A-LUF5834
38.89Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
38.89Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
38.89Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single9CHXS-Carazolol9CHX-β2-S-Carazolol
38.89Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
38.89Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
38.89Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusblt_onOrthosteric Ligandblt1_on
38.89Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
38.89Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.89Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
38.89Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
38.89Consensusleukotriene_onOrthosteric Ligandblt_on
38.89Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
38.89Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
38.89Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
38.46Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
38.46Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
38.10Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
38.10Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.10Single5X93K-87945X93-ETB-K-8794
38.10Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
38.10Single7EZCUKA7EZC-A2A-UKA
38.10Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single7UM4AS26747237UM4-5-HT5A-AS2674723
38.10Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
38.10Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
38.10Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
38.10Consensusendothelin_offOrthosteric Ligandetb_off
38.10Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
38.10Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
38.10Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
37.50Single6PT2KGCHM076PT2-δ-KGCHM07
37.50Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
37.50Single6W25SHU91196W25-MC4-SHU9119-Ca
37.50Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
37.50Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
37.50Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
37.50Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
37.50Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
37.50Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
37.50Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
37.50Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
37.50Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
37.50Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
37.50Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.50Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
37.50Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
37.50Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
37.50Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
37.04Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
37.04Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.04Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
37.04Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.04Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.84Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
36.84Single5IUAQ274563485IUA-A2A-Q27456348-Na
36.84Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
36.84Single5WQCEMPA5WQC-OX2-EMPA
36.84Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
36.84Single6E67BI1671076E67-β2-BI167107-Gs (fused)
36.84Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
36.84Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
36.84Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
36.84Single6S0QZM-2413856S0Q-A2A-ZM-241385
36.84Single6TP6Filorexant6TP6-OX1-Filorexant
36.84Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
36.84Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
36.84Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
36.84Single7C4SS1P7C4S-S1P3-S1P
36.84Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.84Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
36.84Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
36.84Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
36.84Single7WC6LSD7WC6-5-HT2A-LSD
36.84Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
36.84Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
36.84Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
36.84Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
36.84Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
36.84Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
36.84Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
36.84Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
36.84Single8S4DCMF-0198S4D-Apelin-CMF-019
36.84Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
36.84Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
36.84Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
36.84Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
36.84Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
36.84Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
36.84Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
36.84Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.84Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
36.84Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
36.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
36.36Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
36.36Single5WF6UK-4320975WF6-A2A-UK-432097
36.36Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
36.36Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
36.36Single6PT3DPI-2876PT3-δ-DPI-287
36.36Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
36.36Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
36.36Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
36.36Single7SK9CCX6627SK9-ACKR3-CCX662
36.36Single8X5YAstemizole8X5Y-H1-Astemizole
36.36Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
36.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
36.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
36.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
36.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
36.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
36.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
35.71Consensusendothelin_onOrthosteric Ligandetb_on eta_on
35.29Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
35.29Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
35.29Single5WS3EMPA5WS3-OX2-EMPA
35.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.29Single6B73MP11046B73-κ-MP1104
35.29Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
35.29Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
35.29Single6TODEMPA6TOD-OX1-EMPA-Na
35.29Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
35.29Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
35.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
35.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
35.29Single7XRRLemborexant7XRR-OX2-Lemborexant
35.29Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
35.29Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
35.29Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
35.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
35.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
35.29Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
35.29Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
35.29Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
35.29Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
35.29Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
35.29Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
35.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
35.29Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
35.29Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
35.29Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
35.29Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
35.29Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
35.00Single2YDVNECA2YDV-A2A-NECA
35.00Single4DJHJDTic4DJH-κ-JDTic
35.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
35.00Single4UHRCGS216804UHR-A2A-CGS21680
35.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
35.00Single5G53NECA5G53-A2A-NECA-Gs
35.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
35.00Single6J21Aprepitant6J21-NK1-Aprepitant
35.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
35.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
35.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
35.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
35.00Single7PX4PSB-21137PX4-A2A-PSB-2113
35.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
35.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
35.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
35.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
35.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
35.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
35.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
35.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
35.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
35.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
35.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
35.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
35.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
35.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
35.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
35.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
35.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
35.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
35.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
35.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
35.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
35.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
35.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
35.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
34.78Single4IARErgotamine4IAR-5-HT1B-Ergotamine
34.78Single4XT1Fractalkine4XT1-US28-Fractalkine
34.78Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
34.78Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
34.78Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
34.78Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.78Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
34.78Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
34.78Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
34.78Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.78Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.78Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
34.62Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
34.62Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
34.48Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.48Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
34.48Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
33.33Single3RFMCaffeine3RFM-A2A-Caffeine
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
33.33Single4XT3Fractalkine4XT3-US28-Fractalkine
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5JTBZM-2413855JTB-A2A-ZM-241385
33.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
33.33Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single6A93Risperidone6A93-5-HT2A-Risperidone
33.33Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
33.33Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
33.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
33.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
33.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
33.33Single6PS4ICI118-5516PS4-β2-ICI118-551
33.33Single6PS5S-Propranolol6PS5-β2-S-Propranolol
33.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
33.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
33.33Single6TPNHTL66416TPN-OX2-HTL6641
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
33.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
33.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
33.33Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
33.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
33.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
33.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
33.33Single7T32ZM-2413857T32-A2A-ZM-241385
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
33.33Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
33.33Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
33.33Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
33.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
33.33Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
33.33Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
33.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
33.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
33.33Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
33.33Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
33.33Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
33.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
33.33Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
33.33Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
33.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
33.33Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
33.33Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
33.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
33.33Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
33.33Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
33.33Single9BJKNaloxone9BJK-μ-Naloxone-NAM
33.33Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
33.33Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
33.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
33.33Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
33.33Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
33.33Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
33.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
33.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
33.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
33.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
33.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
33.33Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
33.33Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
33.33Consensushca_onOrthosteric Ligandhca2_on
33.33Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
33.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
33.33Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
32.00Single3OE0CVX153OE0-CXCR4-CVX15
32.00Single5WF5UK-4320975WF5-A2A-UK-432097
32.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
32.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
32.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
32.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
32.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
32.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
31.82Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
31.82Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
31.82Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
31.82Single6H7LDobutamine6H7L-β1-Dobutamine
31.82Single6IBLArformoterol6IBL-β1-Arformoterol
31.82Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
31.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
31.82Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
31.82Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
31.82Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
31.82Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
31.82Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
31.82Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
31.82Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
31.82Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
31.82Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
31.82Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
31.82Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.82Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
31.82Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
31.82Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
31.82Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
31.82Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensusprostanoid_offOrthosteric Ligandep_off dp_off
31.58Single2Y04Salbutamol2Y04-β1-Salbutamol
31.58Single3EMLZM-2413853EML-A2A-ZM-241385
31.58Single3NY8ICI118-5513NY8-β2-ICI118-551
31.58Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
31.58Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.58Single4GBRS-Carazolol4GBR-β2-S-Carazolol
31.58Single4QIMANTA XV4QIM-SMO-ANTA XV
31.58Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
31.58Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
31.58Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.58Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.58Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
31.58Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
31.58Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
31.58Single6PS1Timolol6PS1-β2-Timolol
31.58Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
31.58Single6S0LZM-2413856S0L-A2A-ZM-241385
31.58Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
31.58Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.58Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.58Single7BU7BI1671077BU7-β1-BI167107
31.58Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
31.58Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
31.58Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
31.58Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.58Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
31.58Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
31.58Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
31.58Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
31.58Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
31.58Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
31.58Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
31.58Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
31.58Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
31.58Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.58Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
31.58Single8CU6LJ-45178CU6-A2A-LJ-4517
31.58Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.58Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
31.58Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
31.58Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
31.58Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
31.58Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
31.58Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
31.58Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.58Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.58Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
31.58Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
31.58Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
31.58Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
31.58Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
31.58Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Single8JXRLSD8JXR-D1-LSD
31.58Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
31.58Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
31.58Single8T1WCVN4248T1W-GPR6-CVN424
31.58Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
31.58Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
31.58Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
31.58Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
31.58Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
31.58Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
31.58Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
31.58Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
31.58Consensus5ht5_onOrthosteric Ligand5ht5a_on
31.58Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
31.58Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
31.58Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
31.58Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.58Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
31.58Consensusdopamine_offOrthosteric Ligandd2_off d3_off
31.58Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
31.58Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
31.58Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
31.58Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
31.58Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Consensushca_on_gpOrthosteric Ligandhca2_on_gp
31.25Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
31.25Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
31.25Consensus5ht2_onOrthosteric Ligand5ht2b_on
31.25Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
31.03Single8IY6Endothelin-18IY6-ETB-Endothelin-1
31.03Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
30.77Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.77Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
30.77Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
30.77Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
30.77Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
30.77Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.77Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
30.77Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
30.77Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
30.43Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
30.43Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
30.43Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
30.43Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
30.43Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
30.43Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
30.43Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
30.43Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
30.43Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
30.43Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Consensuskisspeptin_onOrthosteric Ligandkiss1_on
30.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
30.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
30.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
30.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
30.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
30.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
30.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
30.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
30.00Single5N2SPSB365N2S-A1-PSB36
30.00Single5TVNLSD5TVN-5-HT2B-LSD
30.00Single5XPRBosentan5XPR-ETB-Bosentan
30.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
30.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
30.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
30.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
30.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
30.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
30.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
30.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
30.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
30.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
30.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
30.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
30.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
30.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
30.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
30.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
30.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
30.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
30.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
30.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
30.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
30.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
30.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
30.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
30.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
30.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
30.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
30.00Consensusbombesin_onOrthosteric Ligandbb2_on
30.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
30.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
30.00Consensusdp_offOrthosteric Liganddp2_off
30.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
30.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
30.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Consensustrace-amine_onOrthosteric Ligandta1_on
29.63Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
29.63Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
29.63Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
29.63Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
29.63Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
29.63Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
29.63Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.63Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
29.63Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
29.63Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
29.63Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
29.41Single6HLLCP999946HLL-NK1-CP99994
29.41Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
29.41Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
29.41Single7SRQLSD7SRQ-5-HT2B-LSD
29.41Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
29.41Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
29.41Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
29.41Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
29.41Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
29.41Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
29.41Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
29.41Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
29.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
29.41Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
29.41Single8K5BNiacin8K5B-HCA2-Niacin
29.41Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
29.41Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
29.41Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
29.41Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.41Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
29.41Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
29.41Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
29.17Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
29.17Single7QA8Peptide7QA8-STE2-Peptide
29.17Single7QA8Peptide7QA8-STE2-Peptide
29.17Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
29.17Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
29.17Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
29.17Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
29.17Single8IEBA1LYA8IEB-GPR156-A1LYA
29.17Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
29.17Single8KIGSHU91198KIG-MC3-SHU9119-Ca
29.17Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
29.17Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
29.17Single8XWNCXCL88XWN-CXCR2-CXCL8
29.17Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.17Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
29.17Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.17Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.17Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
29.17Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
29.03Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
28.57Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
28.57Single4BV0Neurotensin4BV0-NTS1-Neurotensin
28.57Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
28.57Single5D5AS-Carazolol5D5A-β2-S-Carazolol
28.57Single5D5BS-Carazolol5D5B-β2-S-Carazolol
28.57Single5TZRMK86665TZR-FFA1-MK8666
28.57Single5V56TC1145V56-SMO-TC114
28.57Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
28.57Single6E59L-7607356E59-NK1-L-760735
28.57Single6J20Aprepitant6J20-NK1-Aprepitant
28.57Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
28.57Single6OS1TRV0266OS1-AT1-TRV026
28.57Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
28.57Single6WGTLSD6WGT-5-HT2A-LSD
28.57Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
28.57Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
28.57Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
28.57Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.57Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
28.57Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
28.57Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
28.57Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
28.57Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
28.57Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
28.57Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
28.57Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
28.57Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
28.57Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
28.57Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
28.57Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
28.57Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
28.57Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
28.57Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
28.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
28.57Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8XVLZibotentan8XVL-ETA-Zibotentan
28.57Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
28.57Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
28.57Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
28.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
28.57Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
28.57Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
28.57Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
28.57Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
28.57Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
28.57Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
28.57Consensusneurotensin_onOrthosteric Ligandnts1_on
28.57Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
28.57Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.57Consensusrelaxin_onOrthosteric Ligandrxfp4_on
28.57Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
28.57Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
28.00Single6HLOAprepitant6HLO-NK1-Aprepitant
28.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
28.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
28.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
28.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
28.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
28.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
27.78Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
27.78Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
27.78Single4S0VSuvorexant4S0V-OX2-Suvorexant
27.78Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
27.78Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
27.78Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.78Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
27.78Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.78Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
27.78Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
27.78Single6ME2Ramelteon6ME2-MT1-Ramelteon
27.78Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.78Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
27.78Single6TPJSuvorexant6TPJ-OX2-Suvorexant
27.78Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
27.78Single7BR3Elagolix7BR3-GnRH1-Elagolix
27.78Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
27.78Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
27.78Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
27.78Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.78Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.78Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
27.78Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
27.78Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.78Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
27.78Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
27.78Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
27.78Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
27.78Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
27.78Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
27.78Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
27.78Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
27.78Single8Y0HVUF114188Y0H-CXCR3-VUF11418
27.78Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.78Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
27.78Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
27.78Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
27.78Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
27.78Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
27.78Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
27.78Consensusalpha2_offOrthosteric Ligandalpha2c_off
27.78Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
27.78Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.78Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
27.78Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.78Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
27.78Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.78Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.59Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
27.59Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
27.27Single3D4STimolol3D4S-β2-Timolol
27.27Single4AMIBucindolol4AMI-β1-Bucindolol
27.27Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
27.27Single4N4WSANT-14N4W-SMO-SANT-1
27.27Single4PY02MeSATP4PY0-P2Y12-2MeSATP
27.27Single4XEENeurotensin4XEE-NTS1-Neurotensin
27.27Single4XESNeurotensin4XES-NTS1-Neurotensin
27.27Single6CM4Risperidone6CM4-D2-Risperidone
27.27Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
27.27Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
27.27Single6OS2TRV0266OS2-AT1-TRV026
27.27Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
27.27Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
27.27Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
27.27Single6ZG4HTL00099366ZG4-M1-HTL0009936
27.27Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
27.27Single7DFPSpiperone7DFP-D2-Spiperone
27.27Single7K15MKD0467K15-BLT1-MKD046-Na
27.27Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.27Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
27.27Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
27.27Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
27.27Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
27.27Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
27.27Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
27.27Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
27.27Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
27.27Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
27.27Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
27.27Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
27.27Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
27.27Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
27.27Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
27.27Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.27Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
27.27Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
27.27Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.27Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
26.92Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
26.92Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
26.92Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
26.92Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
26.92Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
26.92Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
26.92Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
26.67Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
26.67Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
26.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
26.67Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
26.67Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.32Single2YDOAdenosine2YDO-A2A-Adenosine
26.32Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
26.32Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.32Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
26.32Single5UVIZM-2413855UVI-A2A-ZM-241385
26.32Single6IQLL7458706IQL-D4-L745870
26.32Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
26.32Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
26.32Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.32Single6TPKRetosiban6TPK-OT-Retosiban
26.32Single6V9SGTPL114036V9S-OX1-GTPL11403
26.32Single6VI4JDTic6VI4-κ-JDTic
26.32Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
26.32Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
26.32Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
26.32Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
26.32Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
26.32Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
26.32Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
26.32Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
26.32Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
26.32Single7UL3Famotidine7UL3-H2-Famotidine
26.32Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.32Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
26.32Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.32Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.32Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
26.32Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
26.32Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
26.32Single8IHKAcifran8IHK-HCA3-Acifran
26.32Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
26.32Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
26.32Single8K2WAMG4878K2W-CXCR3-AMG487
26.32Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
26.32Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
26.32Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
26.32Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
26.32Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
26.32Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
26.32Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
26.32Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
26.32Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
26.32Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
26.32Consensusgrh_offOrthosteric Ligandgnrh1_off
26.32Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
26.32Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.32Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.32Consensusvasop-oxy_offOrthosteric Ligandot_off
26.09Single4BUONeurotensin4BUO-NTS1-Neurotensin
26.09Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
26.09Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
26.09Single6K1QIRL25006K1Q-ETB-IRL2500
26.09Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
26.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
26.09Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
26.09Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
26.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
26.09Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.09Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.09Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
26.09Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
26.09Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
26.09Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
26.09Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
26.09Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
26.09Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.09Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
26.09Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.93Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.93Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
25.93Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
25.93Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
25.93Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.93Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.93Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
25.93Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
25.81Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
25.81Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single2Y01Dobutamine2Y01-β1-Dobutamine
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
25.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
25.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
25.00Single4QKX35V4QKX-β2-35V
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single5DHGC-355DHG-NOP-C-35
25.00Single5DHHSB-6121115DHH-NOP-SB-612111
25.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
25.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6H7MSalbutamol6H7M-β1-Salbutamol
25.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
25.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
25.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
25.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
25.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
25.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
25.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8IEIA1LYA8IEI-GPR156-A1LYA
25.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
25.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Single8JJOAlprenolol8JJO-β2-Alprenolol
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
25.00Single8K5DGSK2560738K5D-HCA2-GSK256073
25.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
25.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
25.00Single8X63Mepyramine8X63-H1-Mepyramine
25.00Single8X64Desloratadine8X64-H1-Desloratadine
25.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
25.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
25.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
25.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
25.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
25.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
25.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
25.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
25.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
25.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
25.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
25.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensushistamine_offOrthosteric Ligandh1_off
25.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
25.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.24Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Single6FJ3PTH6FJ3-PTH1-PTH
24.14Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
24.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
24.14Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
24.14Single7SK3CXCL127SK3-ACKR3-CXCL12
24.14Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
24.14Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
24.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
24.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.00Single7F8XNN90567F8X-CCKA-NN9056
24.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
24.00Single8IEPA1LYA8IEP-GPR156-A1LYA
24.00Single8IEPA1LYA8IEP-GPR156-A1LYA
24.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
24.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
24.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
23.81Single2Y00Dobutamine2Y00-β1-Dobutamine
23.81Single4JKVTaladegib4JKV-SMO-Taladegib
23.81Single5WIUNemonapride5WIU-D4-Nemonapride
23.81Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.81Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.81Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.81Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
23.81Single6GPXMK08126GPX-CCR2-MK0812
23.81Single6HLPNetupitant6HLP-NK1-Netupitant
23.81Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.81Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.81Single6PS6Timolol6PS6-β2-Timolol
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
23.81Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single7SINNPS-21437SIN-CaS-NPS-2143
23.81Single7SINNPS-21437SIN-CaS-NPS-2143
23.81Single7W41PD1762527W41-BB2-PD176252
23.81Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
23.81Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
23.81Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
23.81Single8QOTNanobody-E8QOT-μ-Nanobody-E
23.81Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
23.81Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
23.81Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.81Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
23.81Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
23.81Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
23.81Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
23.81Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.81Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
23.81Consensusblt_offOrthosteric Ligandblt1_off
23.81Consensusbombesin_offOrthosteric Ligandbb2_off
23.81Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.81Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
23.81Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.81Consensusep_offOrthosteric Ligandep4_off
23.53Single3OE6IT1t3OE6-CXCR4-IT1t
23.53Single3UZAGTPL92363UZA-A2A-GTPL9236
23.53Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
23.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
23.53Single6ME5Agomelatine6ME5-MT1-Agomelatine
23.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
23.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.53Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.53Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
23.53Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.53Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
23.53Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
23.53Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
23.53Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.53Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
23.53Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
23.53Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.53Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.53Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.53Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
23.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
23.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
23.33Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
23.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
23.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
23.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
23.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
23.33Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
23.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
23.33Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.08Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.08Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
23.08Single7XNACYN1548067XNA-SST2-CYN154806
23.08Single8IEBA1LYA8IEB-GPR156-A1LYA
23.08Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
23.08Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
23.08Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
23.08Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
23.08Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.73Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
22.73Single4U15Tiotropium4U15-M3-Tiotropium
22.73Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.73Single5V57TC1145V57-SMO-TC114
22.73Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
22.73Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.73Single6OL9Tiotropium6OL9-M5-Tiotropium
22.73Single7B6WCyclazosin7B6W-α1b-Cyclazosin
22.73Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
22.73Single7F1TMIP-1a7F1T-CCR5-MIP-1a
22.73Single7R0CAVP7R0C-V2-AVP-Arrestin2
22.73Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
22.73Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
22.73Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
22.73Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
22.73Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
22.73Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
22.73Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
22.73Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.73Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.73Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
22.73Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.73Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
22.73Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
22.73Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
22.73Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
22.73Consensustachykinin_offOrthosteric Ligandnk1_off
22.58Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
22.58Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
22.58Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.58Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
22.58Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.22Single3OE9IT1t3OE9-CXCR4-IT1t
22.22Single3PBLEticlopride3PBL-D3-Eticlopride
22.22Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
22.22Single6LI0C176LI0-GPR52-C17
22.22Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
22.22Single6TP4ACT-4622066TP4-OX1-ACT-462206
22.22Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.22Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
22.22Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
22.22Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
22.22Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
22.22Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
22.22Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.22Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.22Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
22.22Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.22Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
22.22Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
22.22Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
22.22Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
22.22Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
22.22Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
22.22Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
22.22Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
22.22Single9B9Y7DY9B9Y-CB1-7DY
22.22Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
22.22Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.22Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.22Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.22Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.74Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.74Single5CXVTiotropium5CXV-M1-Tiotropium
21.74Single5X33BIIL2605X33-BLT1-BIIL260
21.74Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
21.74Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single6YVRNTS8-136YVR-NTS1-NTS8-13
21.74Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
21.74Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
21.74Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
21.74Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
21.74Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
21.74Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.74Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
21.74Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.74Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.74Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.74Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
21.74Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.74Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.74Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.74Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
21.43Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
21.43Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.21Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.21Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
21.05Single3ODUIT1t3ODU-CXCR4-IT1t
21.05Single4BWBNeurotensin4BWB-NTS1-Neurotensin
21.05Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
21.05Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
21.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.05Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
21.05Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
21.05Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
21.05Single7F8ULintitript7F8U-CCKA-Lintitript
21.05Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.05Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
21.05Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
21.05Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
21.05Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
21.05Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.05Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
21.05Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
21.05Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
21.05Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
21.05Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
21.05Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
21.05Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
21.05Single8IWESpermidine8IWE-TA9-Spermidine
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
21.05Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
21.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.05Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
21.05Single9BA0A1AKN9BA0-CB1-A1AKN
21.05Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
21.05Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.05Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.05Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
21.05Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
21.05Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.83Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
20.83Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
20.83Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.83Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
20.83Single8XVJMacitentan8XVJ-ETA-Macitentan
20.83Single8XVUCXCL28XVU-CXCR2-CXCL2
20.83Single8XWFCXCL38XWF-CXCR2-CXCL3
20.83Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
20.83Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.83Consensuschemerin_onOrthosteric Ligandcml1_on
20.83Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
20.83Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.69Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
20.69Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.69Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
20.59Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.59Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
20.59Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
20.59Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
20.59Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single3RZECidoxepin3RZE-H1-Cidoxepin
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
20.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
20.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
20.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
20.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
20.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
20.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8XQJJN2418XQJ-Apelin-JN241
20.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
20.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
20.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
20.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
19.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
19.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
19.23Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.23Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8IEIA1LYA8IEI-GPR156-A1LYA
19.23Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.23Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.23Consensussomatostatin_offOrthosteric Ligandsst2_off
19.05Single4DAJTiotropium4DAJ-M3-Tiotropium
19.05Single4MQSIperoxo4MQS-M2-Iperoxo
19.05Single4U14Tiotropium4U14-M3-Tiotropium
19.05Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
19.05Single5DSGTiotropium5DSG-M4-Tiotropium
19.05Single5T04Neurotensin5T04-NTS1-Neurotensin
19.05Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
19.05Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
19.05Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
19.05Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
19.05Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
19.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.05Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
19.05Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
19.05Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
19.05Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
19.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.05Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
19.05Single9B9ZA1AKO9B9Z-CB1-A1AKO
19.05Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
19.05Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
19.05Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
19.05Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.05Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
19.05Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
19.05Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
19.05Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
18.75Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
18.75Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
18.75Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
18.75Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.52Single7SK5CXCL127SK5-ACKR3-CXCL12
18.18Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
18.18Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.18Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
18.18Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.18Single6Z4SSR486926Z4S-NTS1-SR48692
18.18Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.18Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
18.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
18.18Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
18.18Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.18Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
18.18Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
18.18Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
18.18Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.18Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8ZMFA1L108ZMF-5-HT2C-A1L10
18.18Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.18Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
18.18Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
17.86Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.65Single3OE8IT1t3OE8-CXCR4-IT1t
17.65Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
17.65Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.65Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.65Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
17.65Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
17.65Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.65Consensusp2y_offOrthosteric Ligandp2y1_off
17.39Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
17.39Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.39Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
17.39Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8EA0Iperoxo8EA0-M3-Iperoxo
17.39Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
17.39Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
17.39Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
17.39Single9BJKNAM9BJK-μ-Naloxone-NAM
17.39Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.39Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.24Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.24Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
17.24Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.24Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
17.24Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.67Single4XNWMRS25004XNW-P2Y1-MRS2500
16.67Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
16.67Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
16.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
16.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
16.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
16.67Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
16.67Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
16.67Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
16.67Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
16.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
16.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
16.67Single8XQJJN2418XQJ-Apelin-JN241
16.67Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
16.67Single8XWACXCL18XWA-CXCR2-CXCL1
16.67Single8XWMCXCL68XWM-CXCR2-CXCL6
16.67Single8XWSCXCL58XWS-CXCR2-CXCL5
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
16.22Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.13Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.13Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
16.13Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
16.13Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
15.79Single4O9RCyclopamine4O9R-SMO-Cyclopamine
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
15.79Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.79Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
15.79Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
15.79Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.79Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
15.79Consensusgq_nucleotideOrthosteric Ligandgq_p2y
15.79Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.79Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.62Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
15.62Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
15.38Single6KNMJN241-96KNM-Apelin-JN241-9
15.38Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
15.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
15.38Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
15.15Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.15Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.15Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.15Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.00Single4QINSAG1.54QIN-SMO-SAG1.5
15.00Single5U09Taranabant5U09-CB1-Taranabant
15.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
15.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
15.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
15.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
15.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
15.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.00Consensusangiotensin_offOrthosteric Ligandat1_off
15.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
15.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
14.81Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
14.81Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
14.81Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
14.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
14.29Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.29Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
14.29Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
14.29Single6ZINSR486926ZIN-NTS1-SR48692
14.29Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
14.29Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
14.29Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
14.29Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
14.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
14.29Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
14.29Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
14.29Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
14.29Consensusopsins_offOrthosteric Ligandrhodopsin_off
14.29Consensussensory_offOrthosteric Ligandopsins_off
13.64Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.64Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
13.64Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.64Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.64Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
13.64Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
13.64Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
13.64Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
13.64Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.64Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
13.64Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
13.51Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.51Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
13.33Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
13.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
13.04Single5CGCHTL142425CGC-mGlu5-HTL14242
13.04Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.04Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.04Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.04Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
13.04Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
13.04Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single7P2L4YI7P2L-mGlu5-4YI
12.50Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.50Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
12.50Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.50Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
12.20Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.12Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.90Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.76Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
11.76Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.76Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.76Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.54Single5CGDHTL142425CGD-mGlu5-HTL14242
11.54Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.54Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
11.54Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
11.54Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
11.11Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.11Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.11Consensussensory_onOrthosteric Ligandopsins_on
10.53Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.53Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.53Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.53Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.53Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.53Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.53Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.53Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.34Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.00Single7UL2SR486927UL2-NTS1-SR48692-Na
10.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
10.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.00Consensusneurotensin_offOrthosteric Ligandnts1_off
10.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.68Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
9.52Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.52Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.52Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.52Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.52Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.52Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.38Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.38Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.09Single6FFIMMPEP6FFI-mGlu5-MMPEP
9.09Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.09Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.82Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
8.70Single6FFHFenobam6FFH-mGlu5-Fenobam
8.70Single6IIVDaltroban6IIV-TP-Daltroban
8.33Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.33Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.00Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
7.69Single6IIURamatroban6IIU-TP-Ramatroban
7.41Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single6D35Cholesterol6D35-SMO-Cholesterol
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.14Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.14Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.14Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.14Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.14Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.14Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.14Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.14Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
7.14Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.14Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
7.14Single7XW7K1-707XW7-TSH-K1-70
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.14Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.14Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.14Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.14Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.14Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.14Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.14Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.14Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.14Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.14Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
7.14Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.14Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.14Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
7.14Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.14Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8WVXNorrin8WVX-LGR4-Norrin
7.14Single8WVYNorrin8WVY-LGR4-Norrin
7.14Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.14Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.14Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.14Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.14Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.14Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.14Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
7.14Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.14Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
6.90Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.25Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.25Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.88Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
5.88Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
5.88Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.88Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single5L7DCholesterol5L7D-SMO-Cholesterol
5.56Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.56Single8HS2Fab0468HS2-GPR20-Fab046
5.56Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.56Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.56Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.26Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.26Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.00Single8JPSCCL78JPS-ACKR1-CCL7
4.76Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
4.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.55Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.55Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.35Single8IYXYL-3658IYX-GPR34-YL-365
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.33Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.33Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.12Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.12Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.03Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.78Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
gi_cannabinoid 8GUR-CB2-CP55,940-Gi1/β1/γ2
8GUS-CB2-HU-308-Gi1/β1/γ2
8GUT-CB2-LEI-102-Gi1/β1/γ2
8GUQ-CB2-Olorinab-Gi1/β1/γ2
6KPF-CB2-PubChem 145915889-Gi1/β1/γ2
6PT0-CB2-WIN 55212-2-Gi1/β1/γ2
6KPG-CB1-AM841-Gi1/β1/γ2
gi_ffa 8J21-FFA3-Butyric acid-Gi1/β1/γ2
8J22-FFA2-TUG-1375-Gi1/β1/γ2
gi_leukotriene 7VKT-BLT1-LTB4-Gi1/β1/γ2
gi_lpa 7TD1-LPA1-LPA-Gi1/β1/γ2
7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
gi_s1p 7VIE-S1P1-S1P-Gi1/β1/γ2
7EW3-S1P3-S1P-Gi1/β1/γ2
7EVY-S1P1-Siponimod-Gi1/β1/γ2
7EW1-S1P5-Siponimod-Gi1/β1/γ2
7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
7VIG-S1P1-CBP-307-Gi1/β1/γ2
7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
7EW4-S1P3-CYM5541-Gi1/β1/γ2
7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7EW0-S1P1-Ozanimod-Gi1/β1/γ2
7EW7-S1P1-SEW2871-Gi1/β1/γ2
Net Summary
Imin 2.73829
Number of Linked Nodes 1044
Number of Links 1227
Number of Hubs 181
Number of Links mediated by Hubs 720
Number of Communities 28
Number of Nodes involved in Communities 228
Number of Links involved in Communities 325
Path Summary
Number Of Nodes in MetaPath 144
Number Of Links MetaPath 143
Number of Shortest Paths 2181043
Length Of Smallest Path 3
Average Path Length 34.6358
Length of Longest Path 66
Minimum Path Strength 0.230113
Average Path Strength 4.97103
Maximum Path Strength 21.403
Minimum Path Correlation 0.700182
Average Path Correlation 0.969447
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.63934
Average % Of Corr. Nodes 31.4249
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.5002
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_class-agi_peptide
gi_sensory
gi_alicarboxylic
gi_amine
gi_lipid
gi_nucleotide
gi_protein



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_lipid.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.