Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 9.9225444
2A:A:Y37 8.2185234
3A:A:L45 4.914178
4A:A:S51 3.3445179
5A:A:K53 5.343336179
6A:A:I207 4.8175429
7A:A:F219 6.9675468
8A:A:H220 9.3275427
9A:A:F222 11.26527
10A:A:Q227 5.2675429
11A:A:R228 6.32409
12A:A:K233 6.56333629
13A:A:W234 5.915629
14A:A:C237 5.9775428
15A:A:F238 11.05409
16A:A:F246 6.1925409
17A:A:V247 3.84754177
18A:A:F273 5.956676259
19A:A:W277 14.895406
20A:A:W281 11.7017625
21A:A:I288 5.67409
22A:A:L289 5.11509
23A:A:F290 5.673336119
24A:A:N292 4.7925409
25A:A:F312 4.848336268
26A:A:F315 9.648506
27A:A:Y318 7.9325406
28A:A:E330 7.38473
29A:A:D331 5.9425474
30A:A:V334 4.4775474
31A:A:K338 11.81475
32A:A:Y339 7.546573
33A:A:F340 11.64754267
34A:A:R342 5.826574
35A:A:E344 8.89754265
36A:A:F345 8.385408
37A:A:Y358 6.1675464
38A:A:Y360 9.4675408
39A:A:F363 11.132575
40A:A:T364 6.774119
41A:A:D368 4.82254119
42A:A:N371 4.7485119
43A:A:R373 6.2975465
44A:A:R374 5.833336114
45A:A:F376 6.87333668
46A:A:R385 9.112565
47A:A:H387 7.6385278
48A:A:L394 3.6925408
49B:B:L7 3.4925218
50B:B:L30 4.6825405
51B:B:T34 3.36754125
52B:B:I37 5.284122
53B:B:V40 4.95754123
54B:B:H54 8.635649
55B:B:K57 12.022529
56B:B:Y59 8.766528
57B:B:M61 4.825446
58B:B:W63 6.84833647
59B:B:Q75 11.945429
60B:B:D76 7.21254239
61B:B:I81 4.45137
62B:B:W82 9.23571749
63B:B:D83 10.23448
64B:B:T86 7.5375446
65B:B:K89 5.43667649
66B:B:I93 5.705407
67B:B:L95 5.0865228
68B:B:W99 10.31629
69B:B:M101 5.8175429
70B:B:Y105 4.383758136
71B:B:Y111 7.2775404
72B:B:C121 3.7375428
73B:B:I123 3.8954286
74B:B:Y124 5.7365226
75B:B:L126 4.55754135
76B:B:E130 5.756503
77B:B:H142 7.812529
78B:B:Y145 6.19714728
79B:B:F151 5.325609
80B:B:I157 5.41407
81B:B:V158 3.545405
82B:B:T159 5.72429
83B:B:D163 10.1125429
84B:B:C166 4.235488
85B:B:W169 8.80833628
86B:B:Q176 7.175424
87B:B:F180 8.374587
88B:B:H183 8.595689
89B:B:D186 6.3975429
90B:B:V187 4.725489
91B:B:R197 6.6025405
92B:B:F199 7.588589
93B:B:V200 6.5425456
94B:B:C204 4.44667627
95B:B:D205 7.33489
96B:B:K209 9.944586
97B:B:W211 8.49667688
98B:B:Q220 7.965457
99B:B:H225 8.95571759
100B:B:D228 8.145429
101B:B:I232 5.09458
102B:B:F234 5.755405
103B:B:F235 7.566146
104B:B:N237 8.0385145
105B:B:F241 7.848556
106B:B:T243 6.2775458
107B:B:D247 8.9725459
108B:B:R251 11.51458
109B:B:F253 7.13667656
110B:B:D258 10.6175457
111B:B:E260 7.2875456
112B:B:M262 6.985404
113B:B:Y264 8.636505
114B:B:F278 6.60254147
115B:B:R283 8.3465129
116B:B:L285 5.49406
117B:B:Y289 7.22857727
118B:B:D290 6.566526
119B:B:C294 3.7525405
120B:B:N295 10.01426
121B:B:V296 3.478505
122B:B:W297 7.1525428
123B:B:L300 5.8254126
124B:B:K301 7.91405
125B:B:R304 7.5125425
126B:B:H311 9.875189
127B:B:R314 13.652528
128B:B:M325 6.9575405
129B:B:W332 10.04729
130B:B:D333 8.48254189
131B:B:K337 8.175186
132B:B:W339 12.294189
133B:B:N340 8.6375449
134E:E:F44 7.026519
135E:E:F62 5.322518
136E:E:Y66 6.2419
137E:E:F69 5.956508
138E:E:V80 4.6125405
139E:E:C82 4.3075409
140E:E:W84 8.26519
141E:E:H97 8.974519
142E:E:F101 10.24419
143E:E:D113 5.8454109
144E:E:P114 7.776509
145E:E:V137 4.7775439
146G:G:V16 4.075407
147G:G:R27 6.738558
148G:G:Y40 9.8854146
149G:G:D48 6.9175409
150G:G:L51 4.0725126
151G:G:V54 4.5825446
152G:G:N59 6.3675449
153G:G:P60 7.895449
154G:G:F61 6.075848
155H:H:?3 10.975410
156L:L:T4 4.256530
157L:L:T6 5.748530
158L:L:F15 6.23754160
159L:L:L16 3.71167600
160L:L:K21 9.132590
161L:L:Y37 8.234510
162L:L:?38 5.5575410
163L:L:?101 7.5721090
164R:R:R45 7.155417
165R:R:M48 7.06416
166R:R:M49 6.8725414
167R:R:Q52 10.8075416
168R:R:Y53 8.298511
169R:R:Y56 6.17857713
170R:R:M59 6.935415
171R:R:Y65 8.174203
172R:R:Y71 10.434203
173R:R:D77 5.795619
174R:R:W79 9.03333616
175R:R:L80 9.342515
176R:R:W82 9.01333619
177R:R:P96 7.9875419
178R:R:Y98 8.706514
179R:R:F99 11.36415
180R:R:F102 9.09833614
181R:R:D103 7.435163
182R:R:K110 10.918518
183R:R:Y111 4.1404
184R:R:W118 13.14419
185R:R:H121 12.29514
186R:R:W128 11.33415
187R:R:S129 6.7675417
188R:R:N130 12.8925418
189R:R:Y131 9.80667615
190R:R:K141 5.044163
191R:R:L148 5.82754155
192R:R:Y149 6.58167695
193R:R:H156 10.0825407
194R:R:F170 5.5165198
195R:R:F173 6.57507
196R:R:L176 5.746509
197R:R:Q179 6.6125437
198R:R:R180 6.322509
199R:R:V181 4.04254199
200R:R:L183 4.8775438
201R:R:Y191 9.66333638
202R:R:V206 4.0325493
203R:R:F224 4.145405
204R:R:Y234 7.91167637
205R:R:F235 5.8154315
206R:R:W236 8.71286739
207R:R:M237 5.7875439
208R:R:L238 4.902508
209R:R:I242 5.242537
210R:R:Y243 7.35638
211R:R:I248 4.39407
212R:R:V249 7.574336
213R:R:F253 9.51466
214R:R:Q257 6.048535
215R:R:L259 5.47535
216R:R:W261 6.674532
217R:R:Y262 5.15625837
218R:R:L265 4.2325407
219R:R:W267 7.794539
220R:R:F269 5.97254313
221R:R:P270 3.47409
222R:R:H277 9.1454107
223R:R:R281 10.2345107
224R:R:F285 9.248336106
225R:R:W290 10.295109
226R:R:V293 3.96254326
227R:R:T295 9.1054104
228R:R:Y299 4.3175437
229R:R:H302 7.028536
230R:R:P304 3.6975409
231R:R:L316 4.3054349
232R:R:K326 7.195469
233R:R:I354 6.415406
234R:R:Q355 7.7575438
235R:R:F356 5.9725837
236R:R:R362 7.7075404
237R:R:Y372 7.5554357
238R:R:Y374 6.634156
239R:R:H377 7.34254157
240R:R:H381 8.192509
241R:R:F382 4.57407
242R:R:Q383 9.4325439
243R:R:F385 8.92405
244R:R:C392 5.74254199
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:M325 G:G:P60 10.78526.71YesYes059
2B:B:M325 G:G:P49 13.40386.71YesNo057
3G:G:D48 G:G:P49 14.03363.22YesNo097
4B:B:S279 G:G:D48 21.05338.83NoYes099
5B:B:S279 G:G:L50 30.7876.01NoNo099
6B:B:M45 G:G:L50 33.2087.07NoNo049
7B:B:L308 B:B:M45 33.41484.24NoNo074
8B:B:C294 B:B:L308 11.59914.76YesNo057
9B:B:C294 B:B:V315 11.16555.12YesNo057
10B:B:H311 B:B:V315 11.18614.15YesNo097
11B:B:D333 B:B:H311 99.695310.08YesYes1899
12B:B:D312 B:B:D333 99.96623.99NoYes059
13B:B:D312 R:R:S175 99.99462.94NoNo058
14R:R:S175 R:R:T401 1004.8NoNo087
15R:R:L176 R:R:T401 99.74578.84YesNo097
16R:R:E397 R:R:L176 54.65536.63NoYes099
17R:R:E397 R:R:R180 54.43784.65NoYes099
18A:A:Y391 R:R:R180 52.97513.38NoYes049
19A:A:Y391 R:R:Y243 13.82314.96NoYes048
20B:B:L308 B:B:W339 22.059421.64NoYes079
21B:B:T329 B:B:W339 11.43069.7NoYes089
22B:B:H311 B:B:T329 77.53886.85YesNo098
23B:B:K337 B:B:W339 11.42878.12YesYes1869
24B:B:H311 B:B:K337 11.626515.72YesYes1896
25A:A:Q390 R:R:R180 24.99413.5NoYes049
26A:A:H387 A:A:Q390 24.7133.71YesNo2784
27A:A:H387 A:A:I383 27.9793.98YesNo088
28A:A:I383 R:R:V252 25.20063.07NoNo087
29A:A:Q384 R:R:V252 24.87978.6NoNo667
30A:A:Q384 R:R:K326 24.87328.14NoYes669
31A:A:D381 R:R:K326 24.36056.91NoYes689
32A:A:D381 A:A:Y360 49.019510.34NoYes088
33A:A:D378 A:A:Y360 72.369816.09NoYes078
34A:A:D378 A:A:I288 33.172712.59NoYes079
35A:A:I288 A:A:V375 10.05643.07YesNo099
36A:A:Y391 R:R:L244 52.45747.03NoNo049
37R:R:I248 R:R:L244 52.15764.28YesNo079
38A:A:L388 R:R:I248 52.4887.14NoYes087
39A:A:L388 A:A:L394 52.33994.15NoYes088
40A:A:L394 A:A:R385 50.50433.64YesYes085
41A:A:D381 A:A:R385 24.985610.72NoYes685
42A:A:R385 A:A:Y358 25.157312.35YesYes654
43A:A:Y358 A:A:Y360 24.83742.98YesYes048
44A:A:F222 B:B:W99 10.003722.05YesYes279
45A:A:N279 A:A:W281 23.75633.39NoYes085
46A:A:L282 A:A:N279 23.607110.98NoNo098
47A:A:F290 A:A:I288 22.12223.77YesYes099
48A:A:F290 A:A:I245 18.10473.77YesNo097
49A:A:I245 A:A:L45 25.64484.28NoYes078
50A:A:K53 A:A:L45 12.07145.64YesYes1798
51A:A:D378 A:A:H362 38.701512.61NoNo079
52A:A:F290 A:A:H362 22.11746.79YesNo1199
53A:A:F290 A:A:T364 17.095111.67YesYes1199
54A:A:N292 A:A:T364 24.13635.85YesYes099
55A:A:S51 A:A:V247 15.08694.85YesYes1797
56A:A:H362 A:A:R374 16.085112.41NoYes1194
57A:A:I56 A:A:N371 10.56055.66NoYes079
58A:A:A48 A:A:S51 13.57831.71NoYes089
59B:B:W332 B:B:Y59 25.42635.79YesYes298
60B:B:M101 B:B:Y59 20.04545.99YesYes298
61B:B:M101 B:B:Y145 19.86587.18YesYes298
62A:A:I235 A:A:L282 22.84524.28NoNo099
63A:A:I235 A:A:I276 22.11512.94NoNo098
64A:A:I276 A:A:L272 21.9424.28NoNo088
65B:B:R314 B:B:W332 30.467919.99YesYes289
66A:A:F246 A:A:L272 24.62767.31YesNo098
67A:A:F246 A:A:L289 11.4083.65YesYes099
68A:A:F345 A:A:L270 14.923910.96YesNo086
69A:A:E344 A:A:L270 11.60845.3YesNo056
70A:A:W281 B:B:D290 14.91278.93YesYes256
71B:B:R283 G:G:L51 13.84294.86YesYes1296
72B:B:L285 B:B:Y264 19.13994.69YesYes065
73B:B:F278 B:B:L285 18.812610.96YesYes076
74B:B:F235 B:B:F278 18.38069.65YesYes1467
75B:B:F235 B:B:N237 17.510112.08YesYes1465
76B:B:G238 B:B:N237 17.20213.39NoYes075
77B:B:F234 B:B:G238 16.99933.01YesNo057
78B:B:F234 B:B:V200 15.20579.18YesYes056
79B:B:L210 B:B:V200 11.96342.98NoYes056
80B:B:L210 B:B:Q220 11.735.32NoYes057
81B:B:W297 B:B:Y289 19.4395.79YesYes287
82B:B:W297 B:B:Y264 19.396115.43YesYes085
83B:B:G162 B:B:Y145 18.9595.79NoYes298
84B:B:G162 B:B:S161 19.14673.71NoNo299
85B:B:H142 B:B:S161 18.5912.55YesNo299
86B:B:C149 B:B:T102 13.45473.38NoNo088
87B:B:C148 B:B:T102 13.18523.38NoNo068
88B:B:C148 B:B:L190 12.92117.94NoNo065
89B:B:C271 B:B:D290 21.31563.11NoYes256
90B:B:R314 B:B:T274 40.05855.17YesNo288
91B:B:S275 B:B:T274 67.51614.8NoNo088
92B:B:L318 B:B:S275 67.54656.01NoNo068
93R:R:F170 R:R:L176 69.25013.65YesYes089
94R:R:F170 R:R:F188 79.2945.36YesNo088
95R:R:F188 R:R:L163 58.95346.09NoNo088
96R:R:I192 R:R:L163 58.95074.28NoNo078
97R:R:I192 R:R:V164 58.84083.07NoNo074
98L:L:?101 R:R:V164 58.74165.64YesNo004
99L:L:?101 R:R:Y149 47.48116.66YesYes905
100L:L:L16 R:R:Y149 47.35754.69YesYes005
101L:L:F15 L:L:L16 50.73233.65YesYes000
102L:L:F15 R:R:D103 30.63617.17YesYes1603
103R:R:D103 R:R:P104 13.44766.44YesNo033
104R:R:D97 R:R:P104 25.338111.27NoNo023
105R:R:D97 R:R:K47 25.08022.77NoNo024
106R:R:D50 R:R:K47 24.31222.77NoNo024
107R:R:D50 R:R:K46 24.061411.06NoNo024
108E:E:L59 R:R:K46 23.06442.82NoNo074
109E:E:L59 E:E:Y66 14.82923.52NoYes179
110E:E:F44 E:E:Y66 10.68815.16YesYes199
111E:E:F69 E:E:G41 10.62091.51YesNo087
112E:E:F92 E:E:G41 10.11613.01NoNo087
113R:R:D103 R:R:E106 19.9947.8YesNo1634
114R:R:E106 R:R:M133 38.20114.06NoNo045
115H:H:?3 R:R:M133 37.03645.07YesNo005
116H:H:?3 R:R:W128 34.8745.11YesYes105
117L:L:?38 R:R:W128 33.84855.64YesYes105
118L:L:?38 L:L:Y37 21.86765.8YesYes100
119E:E:W84 L:L:Y37 14.40565.79YesYes190
120L:L:F15 R:R:K141 18.9036.2YesYes1603
121R:R:E106 R:R:K141 18.50034.05NoYes1643
122R:R:F188 R:R:V387 21.97323.93NoNo089
123R:R:V387 R:R:Y191 21.89526.31NoYes098
124R:R:M237 R:R:Y191 19.72475.99YesYes398
125R:R:M237 R:R:Y234 33.59754.79YesYes397
126L:L:T6 R:R:Y234 18.23078.74YesYes307
127R:R:Q383 R:R:Y191 17.029514.65YesYes398
128R:R:F356 R:R:Q383 17.92544.68YesYes379
129L:L:T6 R:R:F356 11.73873.89YesYes307
130L:L:T6 R:R:H302 20.62378.21YesYes306
131R:R:H302 R:R:L298 33.3973.86YesNo066
132R:R:H277 R:R:L298 12.20623.86YesNo076
133R:R:M230 R:R:Y234 13.59063.59NoYes367
134R:R:H302 R:R:M230 12.87216.57YesNo366
135R:R:L298 R:R:V293 22.79882.98NoYes066
136L:L:H18 R:R:P104 15.602112.2NoNo003
137L:L:N14 R:R:V293 16.19225.91NoYes006
138L:L:H18 L:L:N14 15.8628.93NoNo000
139L:L:V17 R:R:V206 10.25074.81NoYes903
140R:R:F170 R:R:V181 12.25267.87YesYes1989
141R:R:C178 R:R:V181 12.15753.42NoYes089
142R:R:C178 R:R:R180 12.1625.57NoYes089
143R:R:L183 R:R:Y243 10.38997.03YesYes388
144R:R:H184 R:R:R180 16.64964.51NoYes099
145R:R:L183 R:R:W236 12.12493.42YesYes389
146R:R:E240 R:R:H184 15.396411.08NoNo099
147R:R:N233 R:R:T190 18.17418.77NoNo399
148R:R:M187 R:R:Y191 15.33958.38NoYes088
149R:R:E240 R:R:M187 15.3189.47NoNo098
150B:B:L318 B:B:T329 66.85082.95NoNo068
151B:B:C271 B:B:Y289 20.54834.03NoYes257
152A:A:W281 B:B:R314 11.362822.99YesYes258
153B:B:D290 B:B:T274 27.42954.34YesNo268
154R:R:T190 R:R:W236 15.38256.06NoYes399
155R:R:M237 R:R:N233 15.44214.21YesNo399
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:T73 E:E:W84 3.64 0 No Yes 9 9 2 1
E:E:E74 E:E:W84 18.54 1 No Yes 5 9 1 1
E:E:E74 L:L:Y37 4.49 1 No Yes 5 0 1 0
E:E:P85 E:E:W84 6.76 0 No Yes 9 9 2 1
E:E:W84 L:L:Y37 5.79 1 Yes Yes 9 0 1 0
E:E:W84 R:R:Q52 6.57 1 Yes Yes 9 6 1 2
E:E:I123 R:R:Y299 3.63 0 No Yes 9 7 2 1
H:H:?3 R:R:W128 5.11 1 Yes Yes 0 5 2 1
H:H:?3 R:R:N130 27.11 1 Yes Yes 0 8 2 2
L:L:K1 R:R:V293 3.04 32 No Yes 0 6 0 1
L:L:K1 R:R:E294 9.45 32 No No 0 3 0 1
L:L:C2 R:R:Y299 5.38 3 No Yes 0 7 0 1
L:L:N3 R:R:W361 18.08 0 No No 0 4 0 1
L:L:N3 R:R:R362 6.03 0 No Yes 0 4 0 1
L:L:T4 R:R:Y299 4.99 3 Yes Yes 0 7 0 1
L:L:T4 R:R:M306 3.01 3 Yes No 0 4 0 1
L:L:T6 R:R:Y234 8.74 3 Yes Yes 0 7 0 1
L:L:T6 R:R:H302 8.21 3 Yes Yes 0 6 0 1
L:L:T6 R:R:V305 4.76 3 Yes No 0 7 0 1
L:L:T6 R:R:F356 3.89 3 Yes Yes 0 7 0 1
L:L:C7 R:R:H302 10.32 3 No Yes 0 6 0 1
L:L:A8 R:R:H377 4.39 0 No Yes 0 7 0 1
L:L:T9 R:R:H381 6.85 0 No Yes 0 9 0 1
L:L:Q10 R:R:H226 6.18 3 No No 0 6 0 1
L:L:Q10 R:R:M230 4.08 3 No No 0 6 0 1
L:L:Q10 R:R:H302 6.18 3 No Yes 0 6 0 1
L:L:R11 R:R:V293 3.92 32 No Yes 0 6 0 1
L:L:L12 R:R:L148 4.15 15 No Yes 0 5 0 1
L:L:L12 R:R:H377 3.86 15 No Yes 0 7 0 1
L:L:N14 R:R:V293 5.91 0 No Yes 0 6 0 1
L:L:F15 R:R:D103 7.17 16 Yes Yes 0 3 0 1
L:L:F15 R:R:K141 6.2 16 Yes Yes 0 3 0 1
L:L:L16 R:R:A145 3.15 0 Yes No 0 4 0 1
L:L:L16 R:R:Y149 4.69 0 Yes Yes 0 5 0 1
L:L:L16 R:R:V206 2.98 0 Yes Yes 0 3 0 1
L:L:V17 R:R:V206 4.81 9 No Yes 0 3 0 1
L:L:V17 R:R:V212 3.21 9 No No 0 3 0 1
L:L:V17 R:R:L291 5.96 9 No No 0 6 0 1
L:L:H18 R:R:P104 12.2 0 No No 0 3 0 1
L:L:S19 R:R:L142 3 16 No No 0 2 0 1
L:L:K21 R:R:Y149 8.36 9 Yes Yes 0 5 0 1
L:L:K21 R:R:V206 3.04 9 Yes Yes 0 3 0 1
L:L:K21 R:R:P207 13.38 9 Yes No 0 3 0 1
L:L:N22 R:R:L142 6.87 16 No No 0 2 0 1
L:L:F23 R:R:Y146 19.6 0 No No 0 2 0 1
L:L:I26 R:R:P100 3.39 0 No No 0 4 0 1
L:L:L27 R:R:Y41 3.52 0 No No 0 3 0 1
L:L:T30 R:R:F99 14.27 1 No Yes 0 5 0 1
L:L:T30 R:R:D101 8.67 1 No No 0 4 0 1
L:L:T30 R:R:F102 6.49 1 No Yes 0 4 0 1
L:L:V32 R:R:N135 5.91 0 No No 0 3 0 1
L:L:S34 R:R:H121 12.55 1 No Yes 0 4 0 1
L:L:S34 R:R:E123 8.62 1 No No 0 4 0 1
L:L:S34 R:R:N124 5.96 1 No No 0 5 0 1
L:L:T36 R:R:W79 3.64 0 No Yes 0 6 0 1
L:L:Y37 R:R:G78 11.59 1 Yes No 0 5 0 1
L:L:Y37 R:R:W79 13.5 1 Yes Yes 0 6 0 1
L:L:?38 R:R:D77 3.36 1 Yes Yes 0 9 0 1
L:L:?38 R:R:W128 5.64 1 Yes Yes 0 5 0 1
L:L:?38 R:R:S129 7.43 1 Yes Yes 0 7 0 1
L:L:?101 R:R:Y149 6.66 9 Yes Yes 0 5 0 1
L:L:?101 R:R:Y150 4.44 9 Yes No 0 4 0 1
L:L:?101 R:R:I153 5.4 9 Yes No 0 7 0 1
L:L:?101 R:R:S157 11.37 9 Yes No 0 7 0 1
L:L:?101 R:R:I160 5.4 9 Yes No 0 5 0 1
L:L:?101 R:R:F161 5.76 9 Yes No 0 4 0 1
L:L:?101 R:R:V164 5.64 9 Yes No 0 4 0 1
L:L:?101 R:R:V203 7.05 9 Yes No 0 3 0 1
L:L:?101 R:R:P207 9.32 9 Yes No 0 3 0 1
R:R:P100 R:R:Y41 9.74 0 No No 4 3 1 1
R:R:M48 R:R:W79 5.82 1 Yes Yes 6 6 2 1
R:R:M48 R:R:Y98 14.37 1 Yes Yes 6 4 2 2
R:R:D77 R:R:G78 3.35 1 Yes No 9 5 1 1
R:R:D77 R:R:L80 4.07 1 Yes Yes 9 5 1 2
R:R:D77 R:R:W82 10.05 1 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 5.89 1 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 8.05 1 Yes Yes 9 5 1 2
R:R:W79 R:R:Y98 6.75 1 Yes Yes 6 4 1 2
R:R:F99 R:R:W79 10.02 1 Yes Yes 5 6 1 1
R:R:W79 R:R:Y131 14.47 1 Yes Yes 6 5 1 2
R:R:L80 R:R:Y131 9.38 1 Yes Yes 5 5 2 2
R:R:K110 R:R:W82 19.73 1 Yes Yes 8 9 2 2
R:R:E294 R:R:F94 7 0 No No 3 3 1 2
R:R:C95 R:R:F102 6.98 1 No Yes 9 4 2 1
R:R:C134 R:R:C95 7.28 1 No No 9 9 2 2
R:R:D97 R:R:P104 11.27 0 No No 2 3 2 1
R:R:F99 R:R:Y98 7.22 1 Yes Yes 5 4 1 2
R:R:F102 R:R:F99 13.93 1 Yes Yes 4 5 1 1
R:R:D101 R:R:F102 5.97 1 No Yes 4 4 1 1
R:R:D101 R:R:N135 10.77 1 No No 4 3 1 1
R:R:C134 R:R:F102 13.97 1 No Yes 9 4 2 1
R:R:F102 R:R:N135 7.25 1 Yes No 4 3 1 1
R:R:D103 R:R:P104 6.44 16 Yes No 3 3 1 1
R:R:D103 R:R:S105 8.83 16 Yes No 3 1 1 2
R:R:D103 R:R:E106 7.8 16 Yes No 3 4 1 2
R:R:D103 R:R:K141 6.91 16 Yes Yes 3 3 1 1
R:R:E106 R:R:K141 4.05 16 No Yes 4 3 2 1
R:R:K110 R:R:S129 6.12 1 Yes Yes 8 7 2 1
R:R:H121 R:R:P122 10.68 1 Yes No 4 5 1 2
R:R:E123 R:R:H121 9.85 1 No Yes 4 4 1 1
R:R:H121 R:R:N124 5.1 1 Yes No 4 5 1 1
R:R:H121 R:R:W128 23.27 1 Yes Yes 4 5 1 1
R:R:N124 R:R:R126 6.03 1 No No 5 4 1 2
R:R:N130 R:R:W128 11.3 1 Yes Yes 8 5 2 1
R:R:S129 R:R:Y131 7.63 1 Yes Yes 7 5 1 2
R:R:K141 R:R:T138 3 16 Yes No 3 2 1 2
R:R:Y146 R:R:Y150 7.94 0 No No 2 4 1 1
R:R:D373 R:R:L148 4.07 0 No Yes 5 5 2 1
R:R:L148 R:R:Y374 3.52 15 Yes Yes 5 6 1 2
R:R:H377 R:R:L148 11.57 15 Yes Yes 7 5 1 1
R:R:Y149 R:R:Y150 7.94 9 Yes No 5 4 1 1
R:R:I153 R:R:Y149 3.63 9 No Yes 7 5 1 1
R:R:L202 R:R:Y149 8.21 9 No Yes 7 5 2 1
R:R:A152 R:R:H381 7.32 0 No Yes 7 9 2 1
R:R:I153 R:R:L202 5.71 9 No No 7 7 1 2
R:R:H156 R:R:S195 11.16 0 Yes No 7 7 2 2
R:R:H156 R:R:I198 14.58 0 Yes No 7 7 2 2
R:R:H156 R:R:H381 11.94 0 Yes Yes 7 9 2 1
R:R:I160 R:R:S195 4.64 0 No No 5 7 1 2
R:R:I160 R:R:M196 5.83 0 No No 5 4 1 2
R:R:F161 R:R:I165 5.02 0 No No 4 5 1 2
R:R:I192 R:R:V164 3.07 0 No No 7 4 2 1
R:R:H226 R:R:I197 3.98 0 No No 6 5 1 2
R:R:H226 R:R:I198 3.98 0 No No 6 7 1 2
R:R:H201 R:R:V205 6.92 0 No No 6 7 1 2
R:R:E204 R:R:V203 4.28 0 No No 4 3 2 1
R:R:P207 R:R:V206 5.3 9 No Yes 3 3 1 1
R:R:C289 R:R:V212 5.12 9 No No 9 3 2 1
R:R:L291 R:R:V212 2.98 9 No No 6 3 1 1
R:R:M230 R:R:Y234 3.59 3 No Yes 6 7 1 1
R:R:H302 R:R:M230 6.57 3 Yes No 6 6 1 1
R:R:M237 R:R:Y234 4.79 3 Yes Yes 9 7 2 1
R:R:V305 R:R:Y234 11.36 3 No Yes 7 7 1 1
R:R:L309 R:R:Y234 3.52 3 No Yes 7 7 2 1
R:R:F356 R:R:Y234 15.47 3 Yes Yes 7 7 1 1
R:R:M237 R:R:Q383 8.16 3 Yes Yes 9 9 2 2
R:R:C289 R:R:L291 4.76 9 No No 9 6 2 1
R:R:L298 R:R:V293 2.98 0 No Yes 6 6 2 1
R:R:H296 R:R:Y299 3.27 0 No Yes 2 7 2 1
R:R:H302 R:R:L298 3.86 3 Yes No 6 6 1 2
R:R:F356 R:R:L309 3.65 3 Yes No 7 7 1 2
R:R:G353 R:R:Q355 4.93 3 No Yes 9 8 2 2
R:R:F356 R:R:G353 3.01 3 Yes No 7 9 1 2
R:R:F356 R:R:Q355 10.54 3 Yes Yes 7 8 1 2
R:R:Q355 R:R:Q383 10.24 3 Yes Yes 8 9 2 2
R:R:F356 R:R:I380 3.77 3 Yes No 7 6 1 2
R:R:F356 R:R:Q383 4.68 3 Yes Yes 7 9 1 2
R:R:G369 R:R:R362 4.5 0 No Yes 4 4 2 1
R:R:R362 R:R:Y372 7.2 0 Yes Yes 4 7 1 2
R:R:D373 R:R:R362 13.1 0 No Yes 5 4 2 1
R:R:H377 R:R:H381 9.55 15 Yes Yes 7 9 1 1
R:R:H381 R:R:I380 5.3 0 Yes No 9 6 1 2
L:L:A13 R:R:H201 2.93 0 No No 0 6 0 1
L:L:A5 R:R:F356 2.77 0 No Yes 0 7 0 1
R:R:M306 R:R:P360 1.68 0 No No 4 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.68Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
73.53Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
64.71Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
63.89Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
62.86Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
61.76Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
56.76Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
55.56Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
55.56Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
54.05Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
54.05Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
54.05Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
52.78Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
52.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
50.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
50.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
48.78Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
48.65Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
48.65Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
47.50Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
47.22Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
44.74Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
43.24Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
42.11Consensuscalcitonin_onOrthosteric Ligandctlike_on
40.91Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
40.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
39.02Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
37.50Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
37.21Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
36.84Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
36.36Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
35.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
35.90Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
35.71Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
35.56Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
35.00Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
34.15Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
34.15Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
34.15Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
34.09Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
34.09Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
33.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
33.33Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
33.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
33.33Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
33.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
33.33Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
33.33Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
33.33Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
33.33Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
32.61Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
32.61Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
32.61Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
32.56Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
32.56Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
32.56Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
32.56Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
32.56Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
32.56Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
32.56Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
32.50Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
31.91Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
31.91Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
31.82Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
31.82Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
31.82Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
31.82Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
31.71Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
31.71Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
31.71Consensuspac_onOrthosteric Ligandpac1_on
31.58Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
31.58Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
31.25Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
31.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
30.95Single6FJ3PTH6FJ3-PTH1-PTH
30.95Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
30.95Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
30.95Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
30.95Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
30.95Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
30.95Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
30.77Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
30.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
30.43Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
30.43Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
30.43Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
30.23Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
30.23Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
30.23Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
30.23Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
30.23Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
30.23Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
30.23Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
29.79Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
29.79Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
29.79Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.79Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
29.55Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
29.55Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
29.55Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
29.55Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
29.55Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
29.55Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
29.55Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
29.41Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
29.27Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
29.27Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
29.27Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
29.27Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
29.17Consensuspth_onOrthosteric Ligandpth1_on pth2_on
28.89Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
28.89Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
28.57Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
28.57Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
28.26Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
27.91Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
27.91Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
27.91Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
27.91Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
27.91Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
27.91Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
27.66Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
27.50Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
27.27Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
27.27Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
27.27Consensusglp_onOrthosteric Ligandglp1_on glp2_on
27.27Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
27.03Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
26.83Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
26.83Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
26.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
26.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
26.67Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
26.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
26.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
26.32Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
26.32Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
26.32Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
26.19Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
26.19Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
26.19Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
26.09Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
25.58Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.58Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.58Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
25.58Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
25.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
25.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
25.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
25.00Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
25.00Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
24.44Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
24.44Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
24.39Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
24.39Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
24.39Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
23.81Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
23.81Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
23.81Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
23.68Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.68Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
23.68Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
23.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
23.26Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
23.26Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
22.50Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.50Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
22.50Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
22.22Single8T1WCVN4248T1W-GPR6-CVN424
22.22Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.22Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
22.22Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca_on_gpOrthosteric Ligandhca2_on_gp
21.95Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
21.95Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
21.95Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
21.95Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
21.74Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
21.74Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
21.62Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
21.62Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
21.62Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
21.62Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
21.43Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
21.43Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
21.43Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
21.43Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
21.43Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
21.28Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
21.05Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
21.05Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
21.05Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
21.05Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
21.05Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
21.05Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
21.05Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
21.05Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.83Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.83Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.83Consensusbombesin_onOrthosteric Ligandbb2_on
20.83Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
20.83Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.59Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
20.59Single8K5BNiacin8K5B-HCA2-Niacin
20.51Single7DFPSpiperone7DFP-D2-Spiperone
20.51Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
20.51Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.51Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.45Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.45Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
20.45Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.45Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.45Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
20.45Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.45Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
20.45Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.45Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.45Consensusvasop-oxy_onOrthosteric Ligandv2_on
20.45Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
20.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
20.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
20.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
20.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
20.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
20.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.57Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
19.57Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
19.57Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
19.57Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.57Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
19.51Single3NY9ICI118-5513NY9-β2-ICI118-551
19.51Single4UG2CGS216804UG2-A2A-CGS21680
19.51Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
19.51Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
19.51Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
19.51Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
19.51Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
19.51Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
19.44Single2YDOAdenosine2YDO-A2A-Adenosine
19.44Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
19.44Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
19.44Single8K5CAcipimox8K5C-HCA2-Acipimox
19.44Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
19.44Consensushca_onOrthosteric Ligandhca2_on
19.15Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.15Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
19.15Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
19.15Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
19.15Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
19.15Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
19.05Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.05Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
19.05Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
19.05Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
19.05Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
19.05Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.92Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
18.92Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
18.92Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
18.92Single8K5DGSK2560738K5D-HCA2-GSK256073
18.92Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
18.92Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
18.92Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
18.92Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
18.92Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
18.92Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
18.75Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.75Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.75Consensusbradykinin_onOrthosteric Ligandbk2_on
18.75Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
18.75Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.60Single3QAKUK-4320973QAK-A2A-UK-432097
18.60Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
18.60Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
18.60Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
18.60Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
18.60Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
18.60Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.60Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.60Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
18.60Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
18.42Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
18.42Single6PS6Timolol6PS6-β2-Timolol
18.42Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
18.42Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.42Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.42Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
18.42Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.42Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.42Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
18.42Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.42Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
18.42Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.42Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.42Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
18.42Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.42Consensustrace-amine_onOrthosteric Ligandta1_on
18.37Single5GLHEndothelin-15GLH-ETB-Endothelin-1
18.37Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.37Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.18Single5WF5UK-4320975WF5-A2A-UK-432097
18.18Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
18.18Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
18.18Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
18.18Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
18.18Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensusangiotensin_onOrthosteric Ligandat1_on
18.18Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
18.18Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.18Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.18Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.18Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
18.18Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.18Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
18.18Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
18.18Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
17.95Single2YDVNECA2YDV-A2A-NECA
17.95Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
17.95Single4UHRCGS216804UHR-A2A-CGS21680
17.95Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
17.95Single5G53NECA5G53-A2A-NECA-Gs
17.95Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.95Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
17.95Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.95Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.95Single8EA0Iperoxo8EA0-M3-Iperoxo
17.95Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
17.95Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.95Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.95Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.95Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.95Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.95Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.95Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
17.95Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.95Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.95Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.95Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.78Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.78Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.78Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
17.78Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
17.78Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.78Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.78Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
17.78Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
17.78Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
17.78Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.78Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.78Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.78Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.78Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.78Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
17.78Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
17.78Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
17.65Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
17.65Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.50Single4N4WSANT-14N4W-SMO-SANT-1
17.50Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
17.50Single6A93Risperidone6A93-5-HT2A-Risperidone
17.50Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
17.50Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
17.50Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
17.50Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.50Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.50Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.50Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
17.50Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
17.50Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
17.50Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
17.50Single8XYIVUF106618XYI-CXCR3-VUF10661
17.50Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
17.50Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
17.50Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
17.50Consensuslpa_offOrthosteric Ligandlpa1_off
17.50Consensuslpl_offOrthosteric Ligands1p_off lpa_off
17.50Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.50Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.50Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
17.39Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
17.39Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
17.39Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.39Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
17.39Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
17.39Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.39Single8ZRTET-18ZRT-ETB-ET-1
17.39Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
17.39Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.39Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
17.39Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
17.39Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
17.39Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
17.14Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
17.07Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
17.07Single5CGDHTL142425CGD-mGlu5-HTL14242
17.07Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
17.07Single7EZCUKA7EZC-A2A-UKA
17.07Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
17.07Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
17.07Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
17.07Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
17.07Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
17.07Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
17.07Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.07Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
17.07Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.02Single4XT3Fractalkine4XT3-US28-Fractalkine
17.02Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
17.02Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.02Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.02Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.02Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
17.02Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.02Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.02Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
16.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
16.67Single5WF6UK-4320975WF6-A2A-UK-432097
16.67Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
16.67Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single7SK9CCX6627SK9-ACKR3-CCX662
16.67Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
16.67Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
16.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
16.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
16.67Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
16.67Single8X5YAstemizole8X5Y-H1-Astemizole
16.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
16.67Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
16.67Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
16.33Single6IGLIRL16206IGL-ETB-IRL1620
16.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.33Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
16.28Single4XT1Fractalkine4XT1-US28-Fractalkine
16.28Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
16.28Single7QA8Peptide7QA8-STE2-Peptide
16.28Single7QA8Peptide7QA8-STE2-Peptide
16.28Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
16.28Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
16.28Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
16.28Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
16.28Single8WDTphotoNECA8WDT-A2A-photoNECA
16.28Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.28Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
16.28Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
16.28Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.22Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.22Single6ZG9GSK10347026ZG9-M1-GSK1034702
16.22Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
16.22Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.22Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
16.22Single8IHKAcifran8IHK-HCA3-Acifran
16.22Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
16.22Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
16.22Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
16.22Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
16.22Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
16.22Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
16.22Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.22Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
16.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
15.91Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
15.91Single6HLOAprepitant6HLO-NK1-Aprepitant
15.91Single7XNACYN1548067XNA-SST2-CYN154806
15.91Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
15.91Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
15.91Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
15.91Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
15.91Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.79Single3NY8ICI118-5513NY8-β2-ICI118-551
15.79Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
15.79Single4GBRS-Carazolol4GBR-β2-S-Carazolol
15.79Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
15.79Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
15.79Single5TGZAM65385TGZ-CB1-AM6538
15.79Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
15.79Single7UL4Alvimopan7UL4-μ-Alvimopan
15.79Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
15.79Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.79Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.79Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
15.79Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
15.79Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
15.79Single8JJOAlprenolol8JJO-β2-Alprenolol
15.79Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.79Single9AS1DMT9AS1-5-HT2A-DMT
15.79Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.79Single9CHXS-Carazolol9CHX-β2-S-Carazolol
15.79Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
15.79Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
15.79Consensusdopamine_offOrthosteric Ligandd2_off d3_off
15.79Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.69Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
15.56Single6PT2KGCHM076PT2-δ-KGCHM07
15.56Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
15.56Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
15.56Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
15.56Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
15.56Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.56Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.56Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
15.56Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.56Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.56Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
15.38Single2RH1S-Carazolol2RH1-β2-S-Carazolol
15.38Single2YCWS-Carazolol2YCW-β1-S-Carazolol
15.38Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
15.38Single5C1MBU725C1M-μ-BU72
15.38Single5CGCHTL142425CGC-mGlu5-HTL14242
15.38Single5D6LS-Carazolol5D6L-β2-S-Carazolol
15.38Single5JQHS-Carazolol5JQH-β2-S-Carazolol
15.38Single5N2RPSB-365N2R-A2A-PSB-36-Na
15.38Single5N2SPSB365N2S-A1-PSB36
15.38Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
15.38Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
15.38Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
15.38Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.38Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
15.38Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
15.38Single7C4SS1P7C4S-S1P3-S1P
15.38Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.38Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
15.38Single7SINNPS-21437SIN-CaS-NPS-2143
15.38Single7SINNPS-21437SIN-CaS-NPS-2143
15.38Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
15.38Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
15.38Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
15.38Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
15.38Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.38Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.38Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.38Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.38Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.38Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
15.38Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
15.38Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
15.38Single8ZMFA1L108ZMF-5-HT2C-A1L10
15.38Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
15.38Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
15.38Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
15.38Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
15.38Single9HC04YI9HC0-mGlu5-4YI
15.38Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
15.38Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
15.38Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
15.38Consensusadenosine_offOrthosteric Liganda1_off a2_off
15.38Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
15.38Consensusamine_offonOrthosteric Ligandamine_off amine_on
15.38Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
15.38Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
15.38Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
15.38Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
15.38Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
15.38Consensusblt_offOrthosteric Ligandblt1_off
15.38Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
15.38Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
15.38Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
15.38Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.38Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.38Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
15.22Single6JODAngiotensin II6JOD-AT2-Angiotensin II
15.22Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
15.22Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
15.22Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
15.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
15.22Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.09Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
15.00Single4DJHJDTic4DJH-κ-JDTic
15.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
15.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
15.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
15.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
15.00Single6J21Aprepitant6J21-NK1-Aprepitant
15.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
15.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
15.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
15.00Single7P2L4YI7P2L-mGlu5-4YI
15.00Single7PX4PSB-21137PX4-A2A-PSB-2113
15.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
15.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
15.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
15.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
15.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
15.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
15.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
15.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
15.00Single8E0GBU728E0G-μ-BU72
15.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
15.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
15.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
15.00Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
15.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
15.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
15.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
15.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
15.00Consensusa2_onOrthosteric Liganda2b_on
15.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
15.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
15.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
15.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
15.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
15.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
15.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
15.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.89Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
14.89Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.89Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.89Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
14.89Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
14.89Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
14.89Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
14.89Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
14.89Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
14.71Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
14.71Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
14.63Single3D4STimolol3D4S-β2-Timolol
14.63Single4AMIBucindolol4AMI-β1-Bucindolol
14.63Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.63Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
14.63Single5CXVTiotropium5CXV-M1-Tiotropium
14.63Single6CM4Risperidone6CM4-D2-Risperidone
14.63Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
14.63Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
14.63Single6OS2TRV0266OS2-AT1-TRV026
14.63Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
14.63Single6ZG4HTL00099366ZG4-M1-HTL0009936
14.63Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
14.63Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
14.63Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
14.63Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
14.63Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
14.63Single7K15MKD0467K15-BLT1-MKD046-Na
14.63Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
14.63Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
14.63Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
14.63Single7YITNalfurafine7YIT-κ-Nalfurafine
14.63Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.63Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
14.63Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
14.63Single8JWY2-1188JWY-A2A-2-118
14.63Single8JWZAB9288JWZ-A2A-AB928-Na
14.63Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.63Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.63Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
14.63Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.63Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
14.63Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
14.63Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
14.63Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
14.63Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
14.63Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
14.63Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
14.63Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
14.63Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
14.63Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
14.63Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
14.58Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
14.58Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.29Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
14.29Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
14.29Single5X93K-87945X93-ETB-K-8794
14.29Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
14.29Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
14.29Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
14.29Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
14.29Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
14.29Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
14.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
14.29Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
14.29Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
14.29Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
14.29Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
14.29Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
14.29Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
14.29Consensuscck_onOrthosteric Ligandccka_on cckb_on
14.29Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
14.29Consensusendothelin_offOrthosteric Ligandetb_off
14.29Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
14.29Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusgi_sensoryOrthosteric Ligandgi_opsins
14.29Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
14.29Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
14.29Consensusprostanoid_offOrthosteric Ligandep_off dp_off
14.29Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
14.29Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
14.29Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
14.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.95Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
13.95Single5ZTYAM102575ZTY-CB2-AM10257
13.95Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
13.95Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
13.95Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
13.95Single7XN9L-054,5227XN9-SST2-L-054,522
13.95Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
13.95Single8QJ2pN1628QJ2-MC4-pN162-Gs
13.95Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.95Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.95Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
13.95Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
13.95Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
13.95Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
13.95Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
13.95Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
13.95Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.95Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.95Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.95Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.89Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
13.89Single3OE9IT1t3OE9-CXCR4-IT1t
13.89Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.89Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
13.89Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.89Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.89Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
13.89Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
13.89Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
13.89Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
13.89Single9B9Y7DY9B9Y-CB1-7DY
13.89Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.89Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
13.89Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.73Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.64Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
13.64Single7F8XNN90567F8X-CCKA-NN9056
13.64Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
13.64Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
13.64Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
13.64Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.64Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.64Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
13.64Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
13.64Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
13.64Single9M4TSilodosin9M4T-Alpha1A-Silodosin
13.64Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
13.64Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.64Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.64Consensuslpl_onOrthosteric Ligands1p_on lpa_on
13.64Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
13.64Consensussomatostatin_offOrthosteric Ligandsst2_off
13.51Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
13.51Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
13.51Single6B73MP11046B73-κ-MP1104
13.51Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
13.51Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
13.51Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.51Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
13.51Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.51Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.51Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.51Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.51Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.51Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.51Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
13.51Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
13.51Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
13.51Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
13.51Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
13.51Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.51Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.51Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
13.51Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
13.51Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
13.51Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
13.51Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
13.51Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
13.51Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
13.51Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
13.51Single8IWESpermidine8IWE-TA9-Spermidine
13.51Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
13.51Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.51Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
13.51Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
13.51Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
13.51Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.51Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
13.51Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.51Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.51Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
13.51Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.51Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
13.51Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
13.51Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
13.51Consensusalpha2_offOrthosteric Ligandalpha2c_off
13.51Consensusangiotensin_offOrthosteric Ligandat1_off
13.51Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.51Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.51Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.51Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.51Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
13.51Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
13.51Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.51Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.46Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
13.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
13.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.33Single7SK5CXCL127SK5-ACKR3-CXCL12
13.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
13.33Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
13.33Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
13.21Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
13.16Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.16Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
13.16Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
13.16Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
13.16Single4ZJCSB-6740424ZJC-OX1-SB-674042
13.16Single5IU7Q274563465IU7-A2A-Q27456346-Na
13.16Single5JTBZM-2413855JTB-A2A-ZM-241385
13.16Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
13.16Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.16Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
13.16Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
13.16Single6PS0S-Carazolol6PS0-β2-S-Carazolol
13.16Single6PS4ICI118-5516PS4-β2-ICI118-551
13.16Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
13.16Single6TPGEMPA6TPG-OX2-EMPA
13.16Single6V9SGTPL114036V9S-OX1-GTPL11403
13.16Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.16Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
13.16Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.16Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
13.16Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
13.16Single7F61PF-036547467F61-H3-PF-03654746
13.16Single7T32ZM-2413857T32-A2A-ZM-241385
13.16Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.16Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.16Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
13.16Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.16Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
13.16Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
13.16Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
13.16Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
13.16Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
13.16Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
13.16Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
13.16Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
13.16Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.16Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
13.16Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
13.16Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
13.16Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
13.16Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
13.16Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
13.16Single8RLNLUF58348RLN-A2A-LUF5834
13.16Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
13.16Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
13.16Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
13.16Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.16Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.16Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.16Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.16Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.16Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
13.16Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
13.16Single9AS5Mescaline9AS5-5-HT2A-Mescaline
13.16Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
13.16Single9BA0A1AKN9BA0-CB1-A1AKN
13.16Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
13.16Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
13.16Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
13.16Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
13.16Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
13.16Consensusa2_offOrthosteric Liganda2a_off
13.16Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
13.16Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
13.16Consensusalpha1_onOrthosteric Ligandalpha1a_on
13.16Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
13.16Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
13.16Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
13.16Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
13.16Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.16Consensusgrh_offOrthosteric Ligandgnrh1_off
13.16Consensusopsins_offOrthosteric Ligandrhodopsin_off
13.16Consensussensory_offOrthosteric Ligandopsins_off
13.04Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.04Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
13.04Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
13.04Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
13.04Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
13.04Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.04Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.82Single2Y04Salbutamol2Y04-β1-Salbutamol
12.82Single3EMLZM-2413853EML-A2A-ZM-241385
12.82Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
12.82Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.82Single4DAJTiotropium4DAJ-M3-Tiotropium
12.82Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
12.82Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
12.82Single4EJ4Naltrindole4EJ4-δ-Naltrindole
12.82Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
12.82Single4QKX35V4QKX-β2-35V
12.82Single4YAYZD-71554YAY-AT1-ZD-7155
12.82Single5DHHSB-6121115DHH-NOP-SB-612111
12.82Single5DSGTiotropium5DSG-M4-Tiotropium
12.82Single5IU8Q274563475IU8-A2A-Q27456347-Na
12.82Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
12.82Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
12.82Single5UENDU1725UEN-A1-DU172
12.82Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
12.82Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
12.82Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
12.82Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
12.82Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
12.82Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
12.82Single6GPSMK08126GPS-CCR2-MK0812
12.82Single6H7MSalbutamol6H7M-β1-Salbutamol
12.82Single6IIVDaltroban6IIV-TXA2-Daltroban
12.82Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.82Single6PS1Timolol6PS1-β2-Timolol
12.82Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
12.82Single6S0LZM-2413856S0L-A2A-ZM-241385
12.82Single6TOTLemborexant6TOT-OX1-Lemborexant
12.82Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.82Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
12.82Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
12.82Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
12.82Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
12.82Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
12.82Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.82Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
12.82Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.82Single7PYRPSB-21157PYR-A2A-PSB-2115
12.82Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
12.82Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
12.82Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
12.82Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
12.82Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
12.82Single7WC7Lisuride7WC7-5-HT2A-Lisuride
12.82Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.82Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
12.82Single8CU6LJ-45178CU6-A2A-LJ-4517
12.82Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
12.82Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
12.82Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
12.82Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
12.82Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
12.82Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
12.82Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
12.82Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
12.82Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
12.82Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
12.82Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
12.82Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
12.82Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
12.82Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
12.82Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
12.82Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
12.82Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
12.82Single8JXRLSD8JXR-D1-LSD
12.82Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
12.82Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
12.82Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.82Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.82Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
12.82Single8X63Mepyramine8X63-H1-Mepyramine
12.82Single8X64Desloratadine8X64-H1-Desloratadine
12.82Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
12.82Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
12.82Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
12.82Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
12.82Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
12.82Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
12.82Single9H37A1IR09H37-A2A-A1IR0-Na
12.82Single9JEAAtropine9JEA-M1-Atropine
12.82Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
12.82Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
12.82Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.82Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.82Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
12.82Consensusa3_onOrthosteric Liganda3a_on
12.82Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
12.82Consensusalpha2_onOrthosteric Ligandalpha2b_on
12.82Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
12.82Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.82Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.82Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
12.82Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.82Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.82Consensusblt_onOrthosteric Ligandblt1_on
12.82Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
12.82Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
12.82Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
12.82Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
12.82Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
12.82Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
12.82Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.82Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.82Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.82Consensushistamine_offOrthosteric Ligandh1_off
12.82Consensusleukotriene_onOrthosteric Ligandblt_on
12.82Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
12.82Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
12.82Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.82Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.82Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.77Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.77Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.77Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
12.77Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
12.77Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
12.77Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
12.77Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.77Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
12.50Single2Y03Isoprenaline2Y03-β1-Isoprenaline
12.50Single4JKVTaladegib4JKV-SMO-Taladegib
12.50Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
12.50Single5IUAQ274563485IUA-A2A-Q27456348-Na
12.50Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
12.50Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
12.50Single5TVNLSD5TVN-5-HT2B-LSD
12.50Single5WIUNemonapride5WIU-D4-Nemonapride
12.50Single5WIVNemonapride5WIV-D4-Nemonapride-Na
12.50Single5WQCEMPA5WQC-OX2-EMPA
12.50Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
12.50Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
12.50Single6D26Fevipiprant6D26-DP2-Fevipiprant
12.50Single6GPXMK08126GPX-CCR2-MK0812
12.50Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
12.50Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
12.50Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
12.50Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.50Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
12.50Single6S0QZM-2413856S0Q-A2A-ZM-241385
12.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
12.50Single6TP6Filorexant6TP6-OX1-Filorexant
12.50Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
12.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
12.50Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
12.50Single7C61Ergotamine7C61-5-HT1B-Ergotamine
12.50Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
12.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.50Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
12.50Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.50Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
12.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
12.50Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
12.50Single7W41PD1762527W41-BB2-PD176252
12.50Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.50Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
12.50Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
12.50Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
12.50Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
12.50Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
12.50Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
12.50Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
12.50Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GNEKW-63568GNE-A2A-KW-6356-Na
12.50Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8QOTNanobody-E8QOT-μ-Nanobody-E
12.50Single8S4DCMF-0198S4D-Apelin-CMF-019
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
12.50Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
12.50Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.50Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.50Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
12.50Single9B9ZA1AKO9B9Z-CB1-A1AKO
12.50Single9EHSLUF76029EHS-A3A-LUF7602
12.50Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
12.50Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
12.50Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
12.50Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
12.50Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
12.50Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
12.50Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.50Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
12.50Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.50Consensusa3_on_gpOrthosteric Liganda3a_on_gp
12.50Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
12.50Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
12.50Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
12.50Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
12.50Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
12.50Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
12.50Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
12.50Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.50Consensusbombesin_offOrthosteric Ligandbb2_off
12.50Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
12.50Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
12.50Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
12.50Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
12.50Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
12.50Consensusdp_offOrthosteric Liganddp2_off
12.50Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
12.50Consensusep_offOrthosteric Ligandep4_off
12.50Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
12.50Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
12.50Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
12.50Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
12.24Single7SK3CXCL127SK3-ACKR3-CXCL12
12.24Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
12.24Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.24Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.20Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
12.20Single4U15Tiotropium4U15-M3-Tiotropium
12.20Single5V56TC1145V56-SMO-TC114
12.20Single5V57TC1145V57-SMO-TC114
12.20Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.20Single6H7JIsoprenaline6H7J-β1-Isoprenaline
12.20Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
12.20Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
12.20Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
12.20Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
12.20Single6OL9Tiotropium6OL9-M5-Tiotropium
12.20Single6WGTLSD6WGT-5-HT2A-LSD
12.20Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
12.20Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
12.20Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
12.20Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
12.20Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
12.20Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
12.20Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
12.20Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
12.20Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
12.20Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.20Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.20Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
12.20Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
12.20Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
12.20Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
12.20Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
12.20Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
12.20Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
12.20Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
12.20Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.20Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
12.20Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
12.20Single9AS9RS130-1809AS9-5-HT2A-RS130-180
12.20Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
12.20Single9BJKNaloxone9BJK-μ-Naloxone-NAM
12.20Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
12.20Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.20Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.20Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.20Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
12.20Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
12.20Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
12.20Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.20Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
12.12Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
12.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
11.90Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
11.90Single4LDEBI1671074LDE-β2-BI167107
11.90Single4XEENeurotensin4XEE-NTS1-Neurotensin
11.90Single4XESNeurotensin4XES-NTS1-Neurotensin
11.90Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
11.90Single5X33BIIL2605X33-BLT1-BIIL260
11.90Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.90Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
11.90Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
11.90Single6IIURamatroban6IIU-TXA2-Ramatroban
11.90Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
11.90Single6YVRNTS8-136YVR-NTS1-NTS8-13
11.90Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
11.90Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
11.90Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
11.90Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
11.90Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
11.90Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
11.90Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.90Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
11.90Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
11.90Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
11.90Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.90Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
11.90Single8JJ8Formoterol8JJ8-β2-Formoterol
11.90Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
11.90Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
11.90Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.90Single9DGIZ85267113509DGI-CB1-Z8526711350
11.90Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
11.90Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
11.90Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
11.90Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
11.90Consensusalpha1_offOrthosteric Ligandalpha1a_off
11.90Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
11.90Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
11.90Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
11.90Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
11.90Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
11.90Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
11.90Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
11.90Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
11.90Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
11.90Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
11.90Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.90Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
11.90Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
11.90Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
11.90Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
11.90Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
11.90Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
11.90Consensusorexin_onOrthosteric Ligandox2_on
11.76Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
11.76Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.76Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
11.63Single4BUONeurotensin4BUO-NTS1-Neurotensin
11.63Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
11.63Single6H7LDobutamine6H7L-β1-Dobutamine
11.63Single6IBLArformoterol6IBL-β1-Arformoterol
11.63Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
11.63Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
11.63Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
11.63Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
11.63Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
11.63Single7UM4AS26747237UM4-5-HT5A-AS2674723
11.63Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
11.63Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.63Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
11.63Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.63Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
11.63Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
11.63Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
11.63Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.63Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
11.63Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
11.63Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
11.63Single8XVJMacitentan8XVJ-ETA-Macitentan
11.63Single8XVUCXCL28XVU-CXCR2-CXCL2
11.63Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
11.63Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
11.63Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
11.63Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.63Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
11.63Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.63Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.63Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.63Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
11.63Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
11.63Consensuschemerin_onOrthosteric Ligandcml1_on
11.63Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.63Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.63Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.63Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.63Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
11.63Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
11.54Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
11.54Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
11.43Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
11.43Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.43Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.43Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
11.43Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.43Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
11.43Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.43Consensussensory_onOrthosteric Ligandopsins_on
11.36Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
11.36Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
11.36Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.36Single6PT3DPI-2876PT3-δ-DPI-287
11.36Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
11.36Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
11.36Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
11.36Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.36Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.36Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
11.36Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
11.36Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
11.36Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.36Single9IPYJR14a9IPY-C3aB-JR14a
11.36Single9JF4PD1683689JF4-BB1-PD168368
11.36Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
11.36Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.32Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.32Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
11.32Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
11.32Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
11.29Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.11Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
11.11Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.11Single3OE6IT1t3OE6-CXCR4-IT1t
11.11Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single4IARErgotamine4IAR-5-HT1B-Ergotamine
11.11Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
11.11Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
11.11Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
11.11Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
11.11Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
11.11Single8IEBA1LYA8IEB-GPR156-A1LYA
11.11Single8IEIA1LYA8IEI-GPR156-A1LYA
11.11Single8IEIA1LYA8IEI-GPR156-A1LYA
11.11Single8IEPA1LYA8IEP-GPR156-A1LYA
11.11Single8IEPA1LYA8IEP-GPR156-A1LYA
11.11Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.11Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.11Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
11.11Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.11Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.11Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.11Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
11.11Single9LRCHistamine9LRC-H4-Histamine
11.11Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
11.11Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
11.11Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.11Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.11Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
11.11Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
11.11Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.87Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
10.87Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
10.87Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
10.87Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.87Single8IEBA1LYA8IEB-GPR156-A1LYA
10.87Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
10.87Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
10.87Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
10.87Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.87Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
10.87Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.87Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
10.81Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.81Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.81Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.81Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.81Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.81Single5L7IVismodegib5L7I-SMO-Vismodegib
10.81Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.81Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.81Single6LI0C176LI0-GPR52-C17
10.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.81Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
10.81Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
10.81Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
10.81Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
10.81Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
10.81Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
10.81Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.81Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
10.81Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.81Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
10.81Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
10.81Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
10.81Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.81Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.81Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
10.81Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
10.81Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
10.64Single3OE0CVX153OE0-CXCR4-CVX15
10.64Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
10.64Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
10.64Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
10.64Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
10.53Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
10.53Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.53Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
10.53Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
10.53Single3ODUIT1t3ODU-CXCR4-IT1t
10.53Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.53Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.53Single4QINSAG1.54QIN-SMO-SAG1.5
10.53Single4S0VSuvorexant4S0V-OX2-Suvorexant
10.53Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
10.53Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.53Single5U09Taranabant5U09-CB1-Taranabant
10.53Single5WS3EMPA5WS3-OX2-EMPA
10.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.53Single6AKXA4R6AKX-CCR5-A4R
10.53Single6AKYMaraviroc6AKY-CCR5-Maraviroc
10.53Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
10.53Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.53Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
10.53Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
10.53Single6TODEMPA6TOD-OX1-EMPA-Na
10.53Single6TPJSuvorexant6TPJ-OX2-Suvorexant
10.53Single7BR3Elagolix7BR3-GnRH1-Elagolix
10.53Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.53Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.53Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.53Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
10.53Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
10.53Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
10.53Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
10.53Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.53Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.53Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.53Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
10.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
10.53Single8GNGIstradefylline8GNG-A2A-Istradefylline
10.53Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
10.53Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
10.53Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
10.53Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
10.53Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.53Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
10.53Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
10.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.53Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
10.53Single9H2XA1IR19H2X-A2A-A1IR1-Na
10.53Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
10.53Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
10.53Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
10.53Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.53Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
10.53Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.53Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.53Consensusorexin_offOrthosteric Ligandox2_off ox1_off
10.53Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
10.53Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
10.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
10.53Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.42Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.42Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.42Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
10.42Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.42Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
10.26Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.26Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
10.26Single4MBSMaraviroc4MBS-CCR5-Maraviroc
10.26Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.26Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
10.26Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
10.26Single5IUBQ274563445IUB-A2A-Q27456344-Na
10.26Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
10.26Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
10.26Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
10.26Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.26Single5UVIZM-2413855UVI-A2A-ZM-241385
10.26Single6A94Zotepine6A94-5-HT2A-Zotepine
10.26Single6AQFZM-2413856AQF-A2A-ZM-241385
10.26Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.26Single6KUXRS-799486KUX-α2a-RS-79948
10.26Single6MH8ZM-2413856MH8-A2A-ZM-241385
10.26Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.26Single6PS5S-Propranolol6PS5-β2-S-Propranolol
10.26Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
10.26Single6TP3Nemorexant6TP3-OX1-Nemorexant
10.26Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.26Single6VI4JDTic6VI4-κ-JDTic
10.26Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.26Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.26Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.26Single7AROLUF58337ARO-A2A-LUF5833-Na
10.26Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
10.26Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.26Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
10.26Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
10.26Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
10.26Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
10.26Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
10.26Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
10.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.26Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.26Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.26Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
10.26Single7UL3Famotidine7UL3-H2-Famotidine
10.26Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.26Single7VODCariprazine7VOD-5-HT2A-Cariprazine
10.26Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
10.26Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.26Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.26Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.26Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.26Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.26Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.26Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.26Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.26Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
10.26Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
10.26Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
10.26Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.26Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
10.26Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
10.26Single8K2WAMG4878K2W-CXCR3-AMG487
10.26Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
10.26Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
10.26Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
10.26Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.26Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.26Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.26Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
10.26Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
10.26Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
10.26Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
10.26Single8ZPMAMD0708ZPM-CXCR4-AMD070
10.26Single8ZPNAMD31008ZPN-CXCR4-AMD3100
10.26Single9AS3LSD9AS3-5-HT2A-LSD
10.26Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
10.26Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.26Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
10.26Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
10.26Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
10.26Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
10.26Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
10.26Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.26Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.26Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.26Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
10.26Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
10.26Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
10.26Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.26Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.26Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.00Single2Y01Dobutamine2Y01-β1-Dobutamine
10.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.00Single4MQSIperoxo4MQS-M2-Iperoxo
10.00Single4U14Tiotropium4U14-M3-Tiotropium
10.00Single5DHGC-355DHG-NOP-C-35
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single5T04Neurotensin5T04-NTS1-Neurotensin
10.00Single6D27CAY104716D27-DP2-CAY10471
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
10.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
10.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
10.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
10.00Single7BU7BI1671077BU7-β1-BI167107
10.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
10.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
10.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
10.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
10.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
10.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
10.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
10.00Single7V3ZCP559407V3Z-CB1-CP55940
10.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
10.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
10.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
10.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
10.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
10.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
10.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
10.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
10.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
10.00Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
10.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
10.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
10.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
10.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.80Single9KDFRES-701-39KDF-ETB-RES-701-3
9.76Single2Y00Dobutamine2Y00-β1-Dobutamine
9.76Single6E67BI1671076E67-β2-BI167107-Gs(CT)
9.76Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
9.76Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.76Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.76Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
9.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.76Single7WC6LSD7WC6-5-HT2A-LSD
9.76Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
9.76Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.76Single8JXSPF-61428JXS-D1-PF-6142
9.76Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
9.76Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.76Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
9.76Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
9.76Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
9.76Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.76Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
9.76Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
9.76Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
9.52Single3P0GBI1671073P0G-β2-BI167107
9.52Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
9.52Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
9.52Single4BV0Neurotensin4BV0-NTS1-Neurotensin
9.52Single5XR8AM8415XR8-CB1-AM841
9.52Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.52Single6E59L-7607356E59-NK1-L-760735
9.52Single6J20Aprepitant6J20-NK1-Aprepitant
9.52Single6OS1TRV0266OS1-AT1-TRV026
9.52Single7B6WCyclazosin7B6W-α1b-Cyclazosin
9.52Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
9.52Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.52Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
9.52Single7FEECP559407FEE-CB1-CP55940-ZCZ011
9.52Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
9.52Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
9.52Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
9.52Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
9.52Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
9.52Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
9.52Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
9.52Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
9.52Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
9.52Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
9.52Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
9.52Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
9.52Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
9.52Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
9.52Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
9.52Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
9.52Single8XVLZibotentan8XVL-ETA-Zibotentan
9.52Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
9.52Single8ZWFJR14a8ZWF-C3aB-JR14a
9.52Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
9.52Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
9.52Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
9.52Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Consensuslpa_onOrthosteric Ligandlpa1_on
9.52Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
9.52Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusneurotensin_onOrthosteric Ligandnts1_on
9.52Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
9.52Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
9.52Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.52Consensustachykinin_offOrthosteric Ligandnk1_off
9.30Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
9.30Single4RWADIPP-NH24RWA-δ-DIPP-NH2
9.30Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
9.30Single6KQICP559406KQI-CB1-CP55940-Org27569
9.30Single6MXTSalmeterol6MXT-β2-Salmeterol
9.30Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
9.30Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.30Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.30Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
9.30Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
9.30Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.30Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.30Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.30Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.30Single8JJLOlodaterol8JJL-β2-Olodaterol
9.30Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
9.30Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
9.30Single8XWMCXCL68XWM-CXCR2-CXCL6
9.30Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
9.30Single9BJKNAM9BJK-μ-Naloxone-NAM
9.30Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
9.30Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
9.30Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
9.30Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
9.30Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.30Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.30Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
9.30Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.30Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.30Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
9.09Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
9.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
9.09Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
9.09Single6K1QIRL25006K1Q-ETB-IRL2500
9.09Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
9.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
9.09Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
9.09Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
9.09Single8XWFCXCL38XWF-CXCR2-CXCL3
9.09Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
9.09Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
9.09Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
9.09Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
8.89Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
8.89Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.89Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.89Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
8.89Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.89Single8XQJJN2418XQJ-Apelin-JN241
8.89Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
8.89Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
8.89Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.89Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.89Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.70Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
8.70Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
8.70Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.70Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
8.70Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
8.70Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.70Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
8.70Single8XWNCXCL88XWN-CXCR2-CXCL8
8.70Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
8.70Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.70Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.70Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.70Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.57Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
8.57Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
8.57Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
8.57Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
8.57Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
8.57Single8HS2Fab0468HS2-GPR20-Fab046
8.57Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
8.57Single8PWNTheophylline8PWN-A2A-Theophylline
8.51Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
8.51Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.51Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
8.51Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
8.51Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.51Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.51Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.33Single3OE8IT1t3OE8-CXCR4-IT1t
8.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
8.33Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
8.33Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
8.33Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
8.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9CHUNoradrenaline9CHU-β2-Noradrenaline
8.33Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
8.33Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.11Single3UZAGTPL92363UZA-A2A-GTPL9236
8.11Single4XNWMRS25004XNW-P2Y1-MRS2500
8.11Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
8.11Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
8.11Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
8.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
8.11Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
8.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.11Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.11Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
8.11Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
8.11Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
8.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
8.11Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
8.11Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.11Consensus5ht2_onOrthosteric Ligand5ht2b_on
8.11Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.11Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
8.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
8.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.89Single3PBLEticlopride3PBL-D3-Eticlopride
7.89Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
7.89Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
7.89Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
7.89Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
7.89Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.89Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
7.89Single7SRQLSD7SRQ-5-HT2B-LSD
7.89Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
7.89Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
7.89Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
7.89Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.89Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.89Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
7.89Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.89Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.89Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.89Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
7.89Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
7.89Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.89Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.89Single9AS7Psilocin9AS7-5-HT2A-Psilocin
7.89Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.89Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
7.89Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
7.89Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
7.89Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.89Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.89Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.89Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.69Single3PWHZM-2413853PWH-A2A-ZM-241385
7.69Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
7.69Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
7.69Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
7.69Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
7.69Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
7.69Single6ME2Ramelteon6ME2-MT1-Ramelteon
7.69Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
7.69Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
7.69Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
7.69Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
7.69Single7F8ULintitript7F8U-CCKA-Lintitript
7.69Single7F8YDevazepide7F8Y-CCKA-Devazepide
7.69Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
7.69Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
7.69Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
7.69Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
7.69Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
7.69Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
7.69Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
7.69Single7XRRLemborexant7XRR-OX2-Lemborexant
7.69Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
7.69Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
7.69Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
7.69Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
7.69Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
7.69Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
7.69Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
7.69Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.69Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
7.69Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
7.69Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
7.69Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
7.69Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
7.69Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
7.69Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
7.69Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.69Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.69Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
7.69Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
7.69Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.55Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
7.50Single3RZECidoxepin3RZE-H1-Cidoxepin
7.50Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
7.50Single6IQLL7458706IQL-D4-L745870
7.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
7.50Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
7.50Single6TPKRetosiban6TPK-OT-Retosiban
7.50Single6TPNHTL66416TPN-OX2-HTL6641
7.50Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
7.50Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
7.50Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
7.50Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
7.50Single7VV6C48/807VV6-MRGPRX2-C48/80
7.50Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
7.50Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
7.50Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.50Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
7.50Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
7.50Single9ARXSerotonin9ARX-5-HT2A-Serotonin
7.50Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
7.50Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
7.50Consensusvasop-oxy_offOrthosteric Ligandot_off
7.32Single2Y02Carmoterol2Y02-β1-Carmoterol
7.32Single4QIMANTA XV4QIM-SMO-ANTA XV
7.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
7.32Single6DRXLisuride6DRX-5-HT2B-Lisuride
7.32Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
7.32Single7F83PF-051904577F83-Ghrelin-PF-05190457
7.32Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
7.32Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
7.32Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
7.32Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
7.32Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
7.32Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
7.32Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
7.32Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.32Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
7.32Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
7.32Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
7.32Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
7.32Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
7.32Consensuscck_offOrthosteric Ligandccka_off
7.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
7.32Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.32Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
7.32Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
7.32Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
7.32Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
7.14Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
7.14Single5XPRBosentan5XPR-ETB-Bosentan
7.14Single6HLPNetupitant6HLP-NK1-Netupitant
7.14Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
7.14Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
7.14Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.14Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
7.14Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
7.14Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
7.14Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
7.14Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
7.14Single9HAPTolvaptan9HAP-V2-Tolvaptan
7.14Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.14Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.98Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
6.98Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
6.98Single5XRAAM115425XRA-CB1-AM11542
6.98Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
6.98Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
6.98Single7R0CAVP7R0C-V2-AVP-Arrestin2
6.98Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
6.98Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.98Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
6.98Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.98Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.98Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
6.98Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.98Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
6.98Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
6.98Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.82Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.82Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
6.82Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
6.82Single8XQJJN2418XQJ-Apelin-JN241
6.82Single8XWACXCL18XWA-CXCR2-CXCL1
6.82Single8XWSCXCL58XWS-CXCR2-CXCL5
6.82Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
6.67Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
6.67Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8ZPLHF511168ZPL-CXCR4-HF51116
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.52Single6KNMJN241-96KNM-Apelin-JN241-9
6.52Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
6.52Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.52Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.52Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
6.52Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
6.38Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
6.38Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.38Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
6.38Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.38Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
6.38Single8KIGSHU91198KIG-MC3-SHU9119-Ca
6.38Single8WKYPG-9348WKY-MC4-PG-934
6.38Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.38Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.25Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
6.25Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
6.25Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
6.12Single6W25SHU91196W25-MC4-SHU9119-Ca
6.12Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
6.12Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
6.12Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
6.12Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
6.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
6.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.88Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
5.88Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
5.71Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
5.71Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
5.71Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.71Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
5.56Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
5.56Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
5.56Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.56Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.41Single3RFMCaffeine3RFM-A2A-Caffeine
5.41Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.41Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.41Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
5.41Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
5.41Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
5.41Consensusp2y_offOrthosteric Ligandp2y1_off
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6ME5Agomelatine6ME5-MT1-Agomelatine
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Single8JPSCCL78JPS-ACKR1-CCL7
5.26Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
5.26Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
5.13Single6HLLCP999946HLL-NK1-CP99994
5.13Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.13Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
5.13Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
5.13Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
5.13Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
5.13Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.13Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
5.13Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.13Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
5.13Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
5.13Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.13Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
5.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
5.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
5.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
4.88Single3REYXAC3REY-A2A-XAC
4.88Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
4.88Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.88Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.76Single5UIGCmpd-15UIG-A2A-Cmpd-1
4.76Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.76Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.76Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
4.76Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
4.76Single9IYAONO-97105319IYA-GPR55-ONO-9710531
4.65Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
4.65Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.65Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.65Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
4.65Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.65Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
4.65Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.65Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.55Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.55Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.55Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
4.55Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.55Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.44Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.44Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
4.44Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.44Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.44Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
4.44Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.35Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
4.35Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
4.26Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.26Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.26Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
4.26Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.26Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
4.26Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.26Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
4.17Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
4.08Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.08Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.08Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.08Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
4.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.03Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.03Single6D35Cholesterol6D35-SMO-Cholesterol
3.03Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.03Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.03Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.03Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.03Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
3.03Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.03Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.03Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
3.03Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.03Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
3.03Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.03Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.03Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.03Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.03Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.03Single7DTTCa7DTT-CaS-Ca-Ca
3.03Single7DTTCa7DTT-CaS-Ca-Ca
3.03Single7DTUTryptophan7DTU-CaS-Tryptophan
3.03Single7DTUTryptophan7DTU-CaS-Tryptophan
3.03Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.03Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.03Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.03Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.03Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.03Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.03Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.03Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.03Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
3.03Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.03Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.03Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.03Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.03Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.03Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.03Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.03Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
3.03Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.03Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.03Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.03Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.03Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.03Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.03Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.03Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.03Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.03Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.03Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.03Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.03Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.03Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.03Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.03Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.03Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.03Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.03Single7XW7K1-707XW7-TSH-K1-70
3.03Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.03Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.03Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.03Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.03Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.03Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.03Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.03Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.03Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.03Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.03Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.03Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.03Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
3.03Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.03Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.03Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.03Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.03Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.03Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.03Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.03Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.03Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.03Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.03Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.03Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.03Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.03Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.03Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
3.03Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.03Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.03Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.03Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.03Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.03Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.03Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.03Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.03Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.03Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.03Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.03Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.03Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.03Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.03Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.03Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.03Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
3.03Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.03Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.03Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
3.03Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.03Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.03Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.03Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.03Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single8WVXNorrin8WVX-LGR4-Norrin
3.03Single8WVYNorrin8WVY-LGR4-Norrin
3.03Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.03Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.03Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.03Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.03Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.03Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.03Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.03Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
3.03Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.03Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.03Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.03Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.03Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.03Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.03Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.03Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.03Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.03Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.03Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.03Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.03Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.03Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.03Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.03Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.03Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.03Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.03Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.03Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.03Single9KHHNorrin9KHH-LGR4-Norrin
3.03Single9S37NB219S37-LGR4-NB21
3.03Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
2.94Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
2.94Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
2.94Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
2.94Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
2.94Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
2.94Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
2.94Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
2.94Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
2.94Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
2.94Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
2.94Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
2.94Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
2.86Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
2.86Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
2.86Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
2.86Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
2.78Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
2.78Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
2.78Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
2.78Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
2.78Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
2.70Single5L7DCholesterol5L7D-SMO-Cholesterol
2.70Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
2.70Single7WC4Serotonin7WC4-5-HT2A-Serotonin
2.70Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
2.63Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
2.56Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
2.56Single7WC5Psilocin7WC5-5-HT2A-Psilocin
2.56Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
2.50Single6TP4ACT-4622066TP4-OX1-ACT-462206
2.50Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.50Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
2.50Single7UL2SR486927UL2-NTS1-SR48692-Na
2.50Single8HNNSCH5467388HNN-CXCR3-SCH546738
2.50Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
2.50Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
2.50Consensusneurotensin_offOrthosteric Ligandnts1_off
2.50Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
2.44Single4XNVBPTU4XNV-P2Y1-BPTU
2.44Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
2.44Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
2.38Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
2.38Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
2.38Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
2.38Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.33Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.27Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
2.27Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
2.27Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.27Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
2.22Single5TZRMK86665TZR-FFA1-MK8666
2.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
2.22Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
2.22Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
2.22Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
2.22Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
2.22Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
2.22Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
2.17Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
2.17Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
2.17Single4PY02MeSATP4PY0-P2Y12-2MeSATP
2.17Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
2.17Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
2.13Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
2.13Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.04Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
2.04Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.04Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
1.96Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
1.96Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
1.92Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
1.82Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 8F2B
Class B1
SubFamily Peptide
Type Calcitonin
SubType CT (AMY3)
Species Homo Sapiens
Ligand Pramlintide Analogue San45
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2; RAMP3
PDB Resolution 2
Date 2023-08-02
D.O.I. doi.org/10.1038/s41589-023-01393-4
Net Summary
Imin 2.94
Number of Linked Nodes 1096
Number of Links 1400
Number of Hubs 244
Number of Links mediated by Hubs 874
Number of Communities 35
Number of Nodes involved in Communities 369
Number of Links involved in Communities 549
Path Summary
Number Of Nodes in MetaPath 156
Number Of Links MetaPath 155
Number of Shortest Paths 4042526
Length Of Smallest Path 3
Average Path Length 31.9334
Length of Longest Path 66
Minimum Path Strength 1.19
Average Path Strength 6.57265
Maximum Path Strength 24.87
Minimum Path Correlation 0.7
Average Path Correlation 0.994564
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 50.3398
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.635
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• amide binding   • amyloid-beta binding   • binding   • peptide binding   • calcitonin family receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • calcitonin receptor activity   • amylin receptor activity   • calcitonin gene-related peptide receptor activity   • calcitonin binding   • calcitonin family binding   • peptide hormone binding   • hormone binding   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus
Gene OntologyBiological Process• positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of response to stimulus   • calcium-mediated signaling   • regulation of cell communication   • cellular process   • positive regulation of signaling   • catabolic process   • negative regulation of biological process   • RNA metabolic process   • macromolecule catabolic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • post-transcriptional regulation of gene expression   • regulation of RNA metabolic process   • regulation of mRNA catabolic process   • negative regulation of cellular process   • regulation of nucleobase-containing compound metabolic process   • RNA catabolic process   • negative regulation of macromolecule metabolic process   • regulation of biosynthetic process   • mRNA catabolic process   • negative regulation of metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • regulation of catabolic process   • gene expression   • mRNA metabolic process   • macromolecule biosynthetic process   • nucleic acid metabolic process   • nucleobase-containing compound catabolic process   • regulation of mRNA stability   • regulation of gene expression   • negative regulation of gene expression   • biosynthetic process   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • regulation of RNA stability   • nucleic acid catabolic process   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of mRNA metabolic process   • regulation of metabolic process   • positive regulation of ERK1 and ERK2 cascade   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • amylin receptor 1 signaling pathway   • amylin receptor signaling pathway   • calcitonin family receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • response to corticosteroid   • response to lipid   • response to hormone   • response to steroid hormone   • response to chemical   • response to endogenous stimulus   • response to glucocorticoid   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • response to amyloid-beta   • cell surface receptor signaling pathway   • calcitonin gene-related peptide receptor signaling pathway   • multicellular organismal process   • ossification   • amylin receptor 2 signaling pathway   • developmental process   • myeloid leukocyte differentiation   • cellular developmental process   • hemopoiesis   • cell development   • myeloid cell differentiation   • cell differentiation   • osteoclast differentiation   • anatomical structure development   • leukocyte differentiation   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • regulation of multicellular organismal process   • negative regulation of multicellular organismal process   • regulation of ossification   • negative regulation of ossification   • amylin receptor 3 signaling pathway   • membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • protein-containing complex   • amylin receptor complex   • plasma membrane protein complex   • amylin receptor complex 3   • membrane protein complex
Gene OntologyCellular Component• membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • protein-containing complex   • amylin receptor complex   • plasma membrane protein complex   • amylin receptor complex 3   • membrane protein complex   • receptor complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • calcitonin family receptor complex   • amylin receptor complex 2   • amylin receptor complex 1   • axon   • neuron projection   • acrosomal vesicle   • intracellular anatomical structure   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • protein binding   • binding   • signaling receptor binding   • amide binding   • amyloid-beta binding   • peptide binding   • molecular function activator activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • hormone activity   • lipid binding   • identical protein binding   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • biological regulation   • positive regulation of intracellular signal transduction   • regulation of response to stimulus   • calcium-mediated signaling   • regulation of cell communication   • cellular process   • positive regulation of signaling   • apoptotic process   • cell death   • programmed cell death   • positive regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • positive regulation of apoptotic process   • behavior   • multicellular organismal process   • eating behavior   • feeding behavior   • cell-cell signaling   • amylin receptor 1 signaling pathway   • amylin receptor signaling pathway   • calcitonin family receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of cellular component organization   • negative regulation of cellular component organization   • protein-containing complex organization   • negative regulation of biological process   • regulation of cellular component biogenesis   • negative regulation of protein-containing complex assembly   • cellular component organization   • cellular component biogenesis   • regulation of protein-containing complex assembly   • cellular component assembly   • protein-containing complex assembly   • negative regulation of cellular process   • cellular component organization or biogenesis   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • cellular developmental process   • regulation of developmental process   • cell development   • regulation of cell differentiation   • regulation of cell development   • regulation of osteoclast differentiation   • multicellular organism development   • cell differentiation   • osteoclast differentiation   • anatomical structure development   • regulation of immune system process   • regulation of multicellular organismal process   • negative regulation of cell differentiation   • negative regulation of hemopoiesis   • developmental process   • regulation of multicellular organismal development   • negative regulation of leukocyte differentiation   • hemopoiesis   • regulation of myeloid cell differentiation   • negative regulation of developmental process   • regulation of myeloid leukocyte differentiation   • negative regulation of myeloid cell differentiation   • negative regulation of osteoclast differentiation   • negative regulation of myeloid leukocyte differentiation   • negative regulation of cell development   • myeloid cell differentiation   • negative regulation of immune system process   • immune system process   • regulation of hemopoiesis   • negative regulation of multicellular organismal process   • leukocyte differentiation   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • negative regulation of tissue remodeling   • homeostatic process   • negative regulation of bone remodeling   • regulation of bone remodeling   • tissue homeostasis   • regulation of tissue remodeling   • regulation of bone resorption   • bone resorption   • negative regulation of bone resorption   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • amylin receptor 2 signaling pathway   • system process   • sensory perception   • nervous system process   • sensory perception of pain   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • negative regulation of amyloid fibril formation   • regulation of amyloid fibril formation   • amyloid fibril formation   • regulation of primary metabolic process   • negative regulation of supramolecular fiber organization   • protein metabolic process   • negative regulation of protein metabolic process   • negative regulation of macromolecule metabolic process   • regulation of protein metabolic process   • negative regulation of metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • regulation of supramolecular fiber organization   • metabolic process   • macromolecule metabolic process   • supramolecular fiber organization   • regulation of metabolic process   • amylin receptor 3 signaling pathway   • extracellular region   • somatodendritic compartment   • cell body   • neuronal cell body   • extracellular space   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • amylin receptor activity   • calcitonin family receptor activity   • peptide receptor activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • transmembrane signaling receptor activity   • adrenomedullin receptor activity   • positive regulation of ERK1 and ERK2 cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • localization   • import into cell   • receptor internalization   • transport   • receptor-mediated endocytosis   • endocytosis   • establishment of localization   • vesicle-mediated transport   • regulation of biosynthetic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • positive regulation of protein localization to plasma membrane   • regulation of localization   • cellular localization   • regulation of protein localization   • intracellular protein localization   • regulation of protein localization to membrane   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • protein localization to plasma membrane   • positive regulation of protein localization to membrane   • regulation of protein localization to cell periphery   • localization within membrane   • protein localization to membrane   • regulation of cellular localization   • macromolecule localization   • positive regulation of protein localization   • regulation of protein localization to plasma membrane   • establishment of protein localization   • nitrogen compound transport   • protein transport   • regulation of signaling receptor activity   • negative regulation of molecular function   • regulation of molecular function   • cross-receptor inhibition within G protein-coupled receptor heterodimer   • negative regulation of signaling receptor activity   • regulation of G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to endogenous stimulus   • response to chemical   • cellular response to hormone stimulus   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • regulation of receptor recycling   • receptor recycling   • receptor metabolic process   • positive regulation of receptor recycling   • response to oxygen-containing compound   • response to nitrogen compound   • response to amyloid-beta   • heart process   • circulatory system process   • G protein-coupled receptor signaling pathway involved in heart process   • intracellular transport   • establishment of localization in cell   • intracellular protein transport   • adrenomedullin receptor signaling pathway   • response to lipid   • cellular response to oxygen-containing compound   • cellular response to lipid   • response to estradiol   • cellular response to estradiol stimulus   • monoatomic ion transport   • monoatomic cation transport   • calcium ion transport   • metal ion transport   • cell surface   • G protein-coupled receptor dimeric complex   • adrenomedullin receptor complex   • lytic vacuole   • vacuole   • lysosome   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to prostaglandin E   • cellular response to ketone   • extrinsic component of plasma membrane   • catalytic complex   • cytoplasmic side of membrane   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • adaptive thermogenesis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of hormone secretion   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of peptide hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • regulation of secretion   • peptide transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeNH2
PDB ResiduesL:L:?38
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

CodeD6M
PDB ResiduesL:L:?101
Environment DetailsOpen EMBL-EBI Page
CodeD6M
NameN-hexadecanoyl-L-glutamic acid
Synonyms
Identifier
FormulaC21 H39 N O5
Molecular Weight385.538
SMILES
PubChem161955
Formal Charge0
Total Atoms66
Total Chiral Atoms1
Total Bonds65
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8F2B_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKNT 
IVKQMTSGI FETKFQVDK VNFHMFDVG AQRDERRKW IQCFNDVTA 
IIFVVASNR LQAALKLFD SIWNNKWLR DTSVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRDEFL 
RISTASGDG RHYCYPHFT CAVDTENIR RVFNDCRDI IQRMHLRQY 
ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8F2B_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainE
ProteinRAMP3
UniProtO60896
Sequence
>8F2B_Chain_E
CNETGMLER LPLCGKAFA DMMGKVDVW KWCNLSEFI VYYESFTNC 
TEMEANVVG CYWPNPLAQ GFITGIHRQ FFSNCTVDR VHLEDPPDE 
VLIPLIVIP VVLTVAMAG LVVWRSKRT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8F2B_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30988
Sequence
>8F2B_Chain_R
YVVGRKKMM DAQYKCYDR MQQLPAYQG EGPYCNRTW DGWLCWDDT 
PAGVLSYQF CPDYFPDFD PSEKVTKYC DEKGVWFKH PENNRTWSN 
YTMCNAFTP EKLKNAYVL YYLAIVGHS LSIFTLVIS LGIFVFFRS 
LGCQRVTLH KNMFLTYIL NSMIIIIHL VEVVPNGEL VRRDPVSCK 
ILHFFHQYM MACNYFWML CEGIYLHTL IVVAVFTEK QRLRWYYLL 
GWGFPLVPT TIHAITRAV YFNDNCWLS VETHLLYII HGPVMAALV 
VNFFFLLNI VRVLVTKMR ETHEAESHM YLKAVKATM ILVPLLGIQ 
FVVFPWRPS NKMLGKIYD YVMHSLIHF QGFFVATIY CFCNNEVQT 
TVKRQWAQF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F0KB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP31.92023-08-02doi.org/10.1038/s41589-023-01393-4
8F0K (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-1.92023-08-02doi.org/10.1038/s41589-023-01393-4
8F2AB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP32.22023-08-02doi.org/10.1038/s41589-023-01393-4
8F2A (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-2.22023-08-02doi.org/10.1038/s41589-023-01393-4
8F2B (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San45-22023-08-02doi.org/10.1038/s41589-023-01393-4
7TZFB1PeptideCalcitoninCT (AMY3)Homo sapiensAmylin-Gs/β1/γ2; RAMP32.42022-03-23doi.org/10.1126/science.abm9609
7TZF (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensAmylin-2.42022-03-23doi.org/10.1126/science.abm9609
9BTWB1PeptideCalcitoninCT (AMY3)Homo sapiensCagrilintide-Gs/β1/γ2; RAMP332025-04-16To be published
9BTW (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensCagrilintide-32025-04-16To be published




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