psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:E76	E:E:M33	10.83	Yes	No	0	6	8
2	E:E:M33	E:E:V80	15.22	No	Yes	0	8	5
3	E:E:L34	E:E:L88	4.15	No	No	0	5	6
4	E:E:E35	E:E:L39	3.98	No	No	0	3	1
5	E:E:L37	E:E:P38	3.28	Yes	No	0	8	5
6	E:E:C40	E:E:L37	3.17	Yes	Yes	1	9	8
7	E:E:E76	E:E:L37	14.58	Yes	Yes	1	6	8
8	E:E:F92	E:E:L37	6.09	No	Yes	0	8	8
9	E:E:C40	E:E:C72	7.28	Yes	No	0	9	9
10	E:E:C40	E:E:T73	3.38	Yes	No	1	9	9
11	E:E:C40	E:E:E76	3.04	Yes	Yes	1	9	6
12	E:E:F44	E:E:G41	9.03	Yes	No	0	9	7
13	E:E:F44	E:E:Y65	22.69	Yes	Yes	1	9	5
14	E:E:F44	E:E:F69	17.15	Yes	Yes	1	9	8
15	E:E:F44	E:E:I96	13.82	Yes	No	0	9	6
16	E:E:A45	E:E:M48	3.22	No	Yes	1	5	9
17	E:E:A45	E:E:F100	5.55	No	No	1	5	8
18	E:E:D46	E:E:M47	9.7	No	No	0	1	4
19	E:E:K50	E:E:M47	2.88	No	No	0	3	4
20	E:E:M47	E:E:S68	4.6	No	No	0	4	2
21	E:E:G49	E:E:M48	3.49	No	Yes	0	3	9
22	E:E:M48	E:E:W56	25.59	Yes	Yes	1	9	7
23	E:E:M48	E:E:Y65	3.59	Yes	Yes	1	9	5
24	E:E:F100	E:E:M48	4.98	No	Yes	1	8	9
25	E:E:D52	E:E:V51	5.84	No	No	1	6	6
26	E:E:V51	E:E:W56	11.03	No	Yes	1	6	7
27	E:E:E61	E:E:V51	9.98	Yes	No	1	6	6
28	E:E:D52	E:E:W56	15.63	No	Yes	1	6	7
29	E:E:D52	E:E:E61	18.19	No	Yes	1	6	6
30	E:E:V53	E:E:W54	6.13	No	No	0	4	3
31	E:E:E61	E:E:W56	7.63	Yes	Yes	1	6	7
32	E:E:W56	E:E:Y65	17.36	Yes	Yes	1	7	5
33	E:E:F101	E:E:W56	13.03	Yes	Yes	1	9	7
34	E:E:C104	E:E:C57	7.28	No	No	1	9	9
35	E:E:C57	E:E:V106	3.42	No	Yes	1	9	4
36	E:E:L59	E:E:N58	8.24	No	No	0	7	8
37	E:E:E61	E:E:N58	7.89	Yes	No	0	6	8
38	E:E:L59	E:E:S60	6.01	No	No	0	7	7
39	E:E:E61	E:E:S60	4.31	Yes	No	0	6	7
40	E:E:F62	E:E:Y65	4.13	Yes	Yes	1	8	5
41	E:E:F62	E:E:Y66	10.32	Yes	Yes	1	8	9
42	E:E:F101	E:E:F62	11.79	Yes	Yes	1	9	8
43	E:E:F62	R:R:Y53	20.63	Yes	Yes	1	8	1
44	E:E:I63	R:R:K46	2.91	No	No	0	6	4
45	E:E:Y65	E:E:Y66	10.92	Yes	Yes	1	5	9
46	E:E:F69	E:E:Y65	3.09	Yes	Yes	1	8	5
47	E:E:F101	E:E:Y65	5.16	Yes	Yes	1	9	5
48	E:E:F69	E:E:Y66	6.19	Yes	Yes	1	8	9
49	E:E:H97	E:E:Y66	8.71	Yes	Yes	1	9	9
50	E:E:Y66	R:R:M49	10.78	Yes	No	0	9	4
51	E:E:Y66	R:R:Q52	11.27	Yes	Yes	1	9	6
52	E:E:Y66	R:R:Y53	4.96	Yes	Yes	1	9	1
53	E:E:Y66	R:R:Y56	5.96	Yes	Yes	1	9	3
54	E:E:F69	E:E:T73	11.67	Yes	No	1	8	9
55	E:E:F69	E:E:I93	5.02	Yes	Yes	1	8	9
56	E:E:T70	R:R:M49	10.54	No	No	0	9	4
57	E:E:M75	E:E:N71	4.21	No	No	0	1	4
58	E:E:E76	E:E:T73	7.06	Yes	No	1	6	9
59	E:E:C82	E:E:V80	6.83	No	Yes	0	9	5
60	E:E:W84	R:R:Q52	3.29	No	Yes	0	9	6
61	E:E:P85	E:E:Q90	3.16	No	Yes	0	9	9
62	E:E:N86	E:E:P87	6.52	No	No	0	9	5
63	E:E:P87	H:H:?502	2.95	No	No	0	5	0
64	E:E:Q90	R:R:Y56	7.89	Yes	Yes	0	9	3
65	E:E:Q90	R:R:M59	4.08	Yes	No	0	9	5
66	E:E:G91	E:E:T94	3.64	No	No	0	4	7
67	E:E:I93	E:E:I96	5.89	Yes	No	0	9	6
68	E:E:H97	E:E:I93	7.95	Yes	Yes	1	9	9
69	E:E:I93	R:R:Y56	4.84	Yes	Yes	1	9	3
70	E:E:I96	E:E:Q99	6.86	No	No	0	6	4
71	E:E:F101	E:E:H97	3.39	Yes	Yes	1	9	9
72	E:E:H97	R:R:Y56	9.8	Yes	Yes	1	9	3
73	E:E:R98	R:R:Q60	8.18	No	No	0	6	3
74	E:E:F100	E:E:Q99	3.51	No	No	0	8	4
75	E:E:F101	R:R:Y53	22.69	Yes	Yes	1	9	1
76	E:E:S102	R:R:Q60	5.78	No	No	0	7	3
77	E:E:C104	E:E:V106	3.42	No	Yes	1	9	4
78	E:E:D107	E:E:T105	7.23	No	No	0	5	8
79	E:E:V106	R:R:Y53	11.36	Yes	Yes	1	4	1
80	E:E:V106	R:R:D57	5.84	Yes	No	0	4	4
81	E:E:E112	E:E:V109	7.13	No	No	0	4	5
82	E:E:H110	E:E:L111	7.71	No	No	0	4	4
83	E:E:L111	R:R:F285	12.18	No	Yes	0	4	6
84	E:E:D113	E:E:P114	4.83	No	Yes	0	9	9
85	E:E:D113	R:R:T295	2.89	No	No	0	9	4
86	E:E:D113	R:R:H296	6.3	No	No	0	9	2
87	E:E:L119	E:E:P114	3.28	No	Yes	0	9	9
88	E:E:P114	R:R:Y284	9.74	Yes	No	0	9	2
89	E:E:P114	R:R:L297	6.57	Yes	No	0	9	4
90	E:E:P115	E:E:V118	3.53	No	No	0	8	7
91	E:E:I123	E:E:L119	5.71	No	No	0	9	9
92	E:E:I120	E:E:P121	3.39	No	No	0	5	5
93	E:E:L122	R:R:T280	4.42	No	No	0	9	4
94	E:E:I123	R:R:I300	4.42	No	No	0	9	8
95	E:E:I125	E:E:P126	3.39	No	No	0	5	9
96	E:E:V127	R:R:P304	5.3	No	No	0	7	9
97	E:E:T130	R:R:F235	9.08	No	Yes	6	9	5
98	E:E:T130	R:R:F269	6.49	No	Yes	6	9	3
99	E:E:T130	R:R:P304	6.99	No	No	0	9	9
100	E:E:M133	E:E:V137	3.04	Yes	No	6	9	9
101	E:E:M133	R:R:L265	5.65	Yes	Yes	6	9	7
102	E:E:M133	R:R:F269	6.22	Yes	Yes	6	9	3
103	E:E:V137	R:R:L265	4.47	No	Yes	6	9	7
104	E:E:V138	R:R:I242	3.07	No	No	0	9	7
105	E:E:R140	E:E:W139	9	Yes	No	0	8	9
106	E:E:R140	E:E:R143	15.99	Yes	No	0	8	8
107	E:E:R140	R:R:W261	7	Yes	No	0	8	2
108	E:E:S141	R:R:Q257	7.22	No	Yes	9	9	5
109	E:E:S141	R:R:Y262	8.9	No	Yes	9	9	7
110	E:E:K142	R:R:T254	12.01	No	No	0	8	6
111	H:H:?501	R:R:W128	6.13	No	No	8	0	5
112	H:H:?501	R:R:N130	24.64	No	No	8	0	8
113	H:H:?501	R:R:T132	6.61	No	No	0	0	6
114	H:H:?502	R:R:N73	29.57	No	No	0	0	4
115	L:L:K1	R:R:S105	6.12	No	No	0	0	1
116	L:L:K1	R:R:E294	6.75	No	No	0	0	3
117	L:L:C2	L:L:C7	7.28	No	No	0	0	0
118	L:L:N3	R:R:W361	10.17	No	No	0	0	4
119	L:L:T4	L:L:T6	6.28	No	Yes	2	0	0
120	L:L:T4	R:R:M306	4.52	No	No	2	0	4
121	L:L:A5	R:R:F356	5.55	No	Yes	0	0	7
122	L:L:A5	R:R:M376	4.83	No	Yes	0	0	7
123	L:L:T6	R:R:Y234	8.74	Yes	Yes	2	0	7
124	L:L:T6	R:R:H302	6.85	Yes	Yes	0	0	6
125	L:L:T6	R:R:V305	3.17	Yes	No	2	0	7
126	L:L:T6	R:R:M306	3.01	Yes	No	2	0	4
127	L:L:T6	R:R:F356	3.89	Yes	Yes	2	0	7
128	L:L:C7	L:L:R11	6.96	No	No	0	0	0
129	L:L:C7	R:R:H302	5.9	No	Yes	0	0	6
130	L:L:T9	R:R:I198	4.56	No	No	0	0	7
131	L:L:Q10	R:R:H302	7.42	No	Yes	0	0	6
132	L:L:L12	L:L:L16	4.15	No	No	0	0	0
133	L:L:L12	R:R:H377	5.14	No	No	0	0	7
134	L:L:E14	L:L:R17	8.14	No	No	0	0	0
135	L:L:E14	R:R:S292	2.87	No	Yes	0	0	4
136	L:L:E14	R:R:V293	7.13	No	No	0	0	6
137	L:L:F15	L:L:S19	10.57	Yes	No	0	0	0
138	L:L:F15	R:R:L142	4.87	Yes	No	0	0	2
139	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
140	L:L:R17	R:R:L291	7.29	No	No	0	0	6
141	L:L:H18	L:L:S19	5.58	No	No	0	0	0
142	L:L:H18	R:R:P104	6.1	No	No	0	0	3
143	L:L:S20	R:R:L142	3	No	No	11	0	2
144	L:L:S20	R:R:Y146	6.36	No	No	11	0	2
145	L:L:G24	L:L:N21	5.09	No	No	0	0	0
146	L:L:F23	R:R:Y146	21.66	No	No	0	0	2
147	L:L:F23	R:R:Y150	4.13	No	No	0	0	4
148	L:L:G24	L:L:P25	4.06	No	No	0	0	0
149	L:L:L27	L:L:P28	3.28	No	No	0	0	0
150	L:L:T30	R:R:F99	6.49	No	Yes	3	0	5
151	L:L:T30	R:R:D101	8.67	No	Yes	0	0	4
152	L:L:T30	R:R:F102	6.49	No	Yes	3	0	4
153	L:L:N31	L:L:N35	4.09	No	No	0	0	0
154	L:L:N31	L:L:T36	14.62	No	Yes	0	0	0
155	L:L:V32	R:R:T132	6.35	No	No	0	0	6
156	L:L:N35	L:L:S34	2.98	No	Yes	0	0	0
157	L:L:S34	R:R:H121	5.58	Yes	Yes	8	0	4
158	L:L:S34	R:R:E123	5.75	Yes	No	8	0	4
159	L:L:P37	L:L:T36	3.5	No	Yes	3	0	0
160	L:L:T36	R:R:W79	6.06	Yes	Yes	3	0	6
161	L:L:P37	R:R:D77	3.22	No	No	0	0	9
162	L:L:P37	R:R:W79	5.4	No	Yes	3	0	6
163	R:R:R45	R:R:Y41	17.49	No	No	0	7	3
164	R:R:K47	R:R:Y98	4.78	No	Yes	0	4	4
165	R:R:Q52	R:R:Y56	19.16	Yes	Yes	1	6	3
166	R:R:Q52	R:R:W76	16.43	Yes	Yes	1	6	8
167	R:R:C55	R:R:W76	9.14	No	Yes	0	9	8
168	R:R:C55	R:R:C81	7.28	No	No	0	9	9
169	R:R:W76	R:R:Y56	9.65	Yes	Yes	1	8	3
170	R:R:L62	R:R:R58	6.07	No	No	0	3	3
171	R:R:L62	R:R:R74	14.58	No	No	0	3	4
172	R:R:G67	R:R:Y65	4.35	No	No	4	2	3
173	R:R:Y65	R:R:Y71	5.96	No	Yes	4	3	3
174	R:R:D84	R:R:Y65	5.75	No	No	4	4	3
175	R:R:G67	R:R:Y71	4.35	No	Yes	4	2	3
176	R:R:G69	R:R:P70	4.06	No	No	0	1	1
177	R:R:A87	R:R:P70	3.74	No	No	0	4	1
178	R:R:D84	R:R:Y71	18.39	No	Yes	4	4	3
179	R:R:P86	R:R:Y71	12.52	No	Yes	4	2	3
180	R:R:C72	R:R:T85	3.38	No	Yes	0	9	7
181	R:R:C112	R:R:C72	5.46	No	No	0	9	9
182	R:R:C72	R:R:W118	10.45	No	Yes	0	9	9
183	R:R:D83	R:R:R74	14.29	No	No	0	5	4
184	R:R:T75	R:R:W118	3.64	No	Yes	0	5	9
185	R:R:G78	R:R:W76	8.44	No	Yes	0	5	8
186	R:R:D77	R:R:W82	10.05	No	Yes	0	9	9
187	R:R:D77	R:R:Y131	6.9	No	Yes	0	9	5
188	R:R:W79	R:R:Y98	5.79	Yes	Yes	3	6	4
189	R:R:F99	R:R:W79	6.01	Yes	Yes	3	5	6
190	R:R:F102	R:R:W79	5.01	Yes	Yes	3	4	6
191	R:R:W79	R:R:Y131	14.47	Yes	Yes	3	6	5
192	R:R:L80	R:R:Q93	5.32	Yes	No	0	5	6
193	R:R:L80	R:R:P96	13.14	Yes	Yes	0	5	9
194	R:R:L80	R:R:V108	2.98	Yes	Yes	3	5	7
195	R:R:L80	R:R:Y131	8.21	Yes	Yes	3	5	5
196	R:R:S91	R:R:W82	4.94	No	Yes	0	5	9
197	R:R:Q93	R:R:W82	7.67	No	Yes	0	6	9
198	R:R:V108	R:R:W82	3.68	Yes	Yes	3	7	9
199	R:R:K110	R:R:W82	6.96	Yes	Yes	3	8	9
200	R:R:W118	R:R:W82	6.56	Yes	Yes	3	9	9
201	R:R:S129	R:R:W82	4.94	No	Yes	3	7	9
202	R:R:P86	R:R:T85	5.25	No	Yes	4	2	7
203	R:R:T85	R:R:V89	3.17	Yes	No	4	7	5
204	R:R:S91	R:R:T85	4.8	No	Yes	0	5	7
205	R:R:P86	R:R:V89	12.37	No	No	4	2	5
206	R:R:E114	R:R:G88	4.91	No	No	0	2	8
207	R:R:L90	R:R:T109	2.95	No	No	0	4	5
208	R:R:L90	R:R:Y111	9.38	No	No	0	4	4
209	R:R:F94	R:R:K107	8.69	No	No	0	3	3
210	R:R:C95	R:R:P96	3.77	Yes	Yes	0	9	9
211	R:R:C95	R:R:E106	3.04	Yes	No	0	9	4
212	R:R:C95	R:R:V108	3.42	Yes	Yes	0	9	7
213	R:R:C134	R:R:C95	5.46	No	Yes	0	9	9
214	R:R:P96	R:R:Y98	8.34	Yes	Yes	0	9	4
215	R:R:F102	R:R:P96	4.33	Yes	Yes	0	4	9
216	R:R:D97	R:R:P104	4.83	No	No	0	2	3
217	R:R:F99	R:R:Y98	6.19	Yes	Yes	3	5	4
218	R:R:F102	R:R:F99	3.22	Yes	Yes	3	4	5
219	R:R:D101	R:R:N135	14.81	Yes	No	0	4	3
220	R:R:D101	R:R:T138	2.89	Yes	No	0	4	2
221	R:R:C134	R:R:F102	5.59	No	Yes	0	9	4
222	R:R:F102	R:R:N135	3.62	Yes	No	0	4	3
223	R:R:D103	R:R:P104	4.83	No	No	0	3	3
224	R:R:D103	R:R:S105	4.42	No	No	0	3	1
225	R:R:D103	R:R:E106	7.8	No	No	0	3	4
226	R:R:V108	R:R:Y131	10.09	Yes	Yes	3	7	5
227	R:R:K110	R:R:W118	25.53	Yes	Yes	3	8	9
228	R:R:K110	R:R:S129	9.18	Yes	No	3	8	7
229	R:R:D113	R:R:V117	2.92	No	No	0	5	5
230	R:R:D113	R:R:F119	8.36	No	No	0	5	4
231	R:R:T127	R:R:W118	4.85	No	Yes	0	4	9
232	R:R:K120	R:R:N125	4.2	No	No	0	1	7
233	R:R:H121	R:R:P122	6.1	Yes	No	0	4	5
234	R:R:E123	R:R:H121	3.69	No	Yes	8	4	4
235	R:R:H121	R:R:W128	19.04	Yes	No	8	4	5
236	R:R:N124	R:R:R126	25.31	No	No	0	5	4
237	R:R:N130	R:R:W128	4.52	No	No	8	8	5
238	R:R:F137	R:R:K141	4.96	No	No	13	1	3
239	R:R:F137	R:R:K366	9.93	No	No	13	1	3
240	R:R:P139	R:R:T138	5.25	No	No	0	3	2
241	R:R:K141	R:R:K366	4.31	No	No	13	3	3
242	R:R:L142	R:R:Y146	11.72	No	No	11	2	2
243	R:R:K370	R:R:N144	5.6	No	No	14	4	4
244	R:R:N144	R:R:Y374	11.63	No	Yes	14	4	6
245	R:R:H377	R:R:L148	18	No	No	0	7	5
246	R:R:Y149	R:R:Y150	4.96	Yes	No	0	5	4
247	R:R:I153	R:R:Y149	10.88	No	Yes	12	7	5
248	R:R:L202	R:R:Y149	8.21	No	Yes	12	7	5
249	R:R:F382	R:R:L151	3.65	No	No	0	7	5
250	R:R:A152	R:R:H381	7.32	No	No	0	7	9
251	R:R:I153	R:R:L202	5.71	No	No	12	7	7
252	R:R:F382	R:R:G155	7.53	No	No	0	7	8
253	R:R:H156	R:R:I198	10.61	No	No	0	7	7
254	R:R:H156	R:R:I199	3.98	No	No	0	7	7
255	R:R:H156	R:R:H381	9.55	No	No	0	7	9
256	R:R:G384	R:R:S159	3.71	No	No	0	9	9
257	R:R:I160	R:R:I192	4.42	No	No	0	5	7
258	R:R:I160	R:R:S195	6.19	No	No	0	5	7
259	R:R:I160	R:R:M196	2.92	No	No	0	5	4
260	R:R:F161	R:R:I165	6.28	No	No	0	4	5
261	R:R:F385	R:R:T162	7.78	No	No	0	5	6
262	R:R:A388	R:R:T162	3.36	No	No	0	8	6
263	R:R:F188	R:R:L163	6.09	No	Yes	0	8	8
264	R:R:L163	R:R:Y191	4.69	Yes	Yes	0	8	8
265	R:R:I192	R:R:L163	4.28	No	Yes	0	7	8
266	R:R:A388	R:R:L163	3.15	No	Yes	0	8	8
267	R:R:I192	R:R:V164	4.61	No	No	0	7	4
268	R:R:F188	R:R:S166	6.61	No	No	0	8	9
269	R:R:C392	R:R:S166	6.89	Yes	No	0	9	9
270	R:R:K185	R:R:L167	4.23	Yes	No	0	6	6
271	R:R:F170	R:R:V181	9.18	Yes	Yes	15	8	9
272	R:R:F170	R:R:H184	3.39	Yes	Yes	0	8	9
273	R:R:F170	R:R:K185	4.96	Yes	Yes	15	8	6
274	R:R:C392	R:R:F170	4.19	Yes	Yes	0	9	8
275	R:R:F172	R:R:F173	9.65	No	Yes	0	2	7
276	R:R:F172	R:R:R174	3.21	No	No	0	2	7
277	R:R:F172	R:R:F409	4.29	No	No	0	2	3
278	R:R:F173	R:R:L176	3.65	Yes	No	10	7	9
279	R:R:F173	R:R:T401	10.38	Yes	Yes	10	7	7
280	R:R:F173	R:R:V402	3.93	Yes	No	0	7	5
281	R:R:F173	R:R:Q405	8.2	Yes	No	10	7	4
282	R:R:L176	R:R:S175	3	No	No	0	9	8
283	R:R:L176	R:R:T401	2.95	No	Yes	10	9	7
284	R:R:G177	R:R:V181	3.68	No	Yes	0	7	9
285	R:R:C178	R:R:V181	3.42	No	Yes	0	8	9
286	R:R:Q179	R:R:Y243	5.64	Yes	Yes	9	7	8
287	R:R:Q179	R:R:Q257	7.68	Yes	Yes	9	7	5
288	R:R:L259	R:R:Q179	11.98	Yes	Yes	0	5	7
289	R:R:H184	R:R:R180	9.03	Yes	No	0	9	9
290	R:R:R180	R:R:Y243	4.12	No	Yes	0	9	8
291	R:R:K185	R:R:V181	3.04	Yes	Yes	15	6	9
292	R:R:L259	R:R:T182	2.95	Yes	No	0	5	5
293	R:R:L183	R:R:W236	4.56	No	Yes	0	8	9
294	R:R:E240	R:R:L183	5.3	No	No	0	9	8
295	R:R:L183	R:R:Y243	7.03	No	Yes	0	8	8
296	R:R:E240	R:R:H184	9.85	No	Yes	0	9	9
297	R:R:H184	R:R:Y391	4.36	Yes	Yes	0	9	8
298	R:R:N186	R:R:W236	14.69	No	Yes	2	9	9
299	R:R:N186	R:R:Y263	6.98	No	No	0	9	5
300	R:R:N186	R:R:W267	4.52	No	Yes	2	9	9
301	R:R:M187	R:R:Y191	4.79	No	Yes	2	8	8
302	R:R:M187	R:R:W236	3.49	No	Yes	2	8	9
303	R:R:M187	R:R:M237	2.89	No	Yes	2	8	9
304	R:R:N233	R:R:T190	8.77	Yes	No	2	9	9
305	R:R:T190	R:R:W236	4.85	No	Yes	2	9	9
306	R:R:T190	R:R:W267	6.06	No	Yes	2	9	9
307	R:R:N233	R:R:Y191	11.63	Yes	Yes	2	9	8
308	R:R:M237	R:R:Y191	4.79	Yes	Yes	2	9	8
309	R:R:Q383	R:R:Y191	9.02	Yes	Yes	2	9	8
310	R:R:G384	R:R:Y191	7.24	No	Yes	0	9	8
311	R:R:V387	R:R:Y191	5.05	No	Yes	0	9	8
312	R:R:L193	R:R:M229	7.07	No	No	0	6	4
313	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
314	R:R:H226	R:R:I197	6.63	No	No	0	6	5
315	R:R:I197	R:R:M229	2.92	No	No	0	5	4
316	R:R:H226	R:R:I198	5.3	No	No	0	6	7
317	R:R:I199	R:R:V203	3.07	No	No	0	7	3
318	R:R:H201	R:R:V205	12.45	No	No	0	6	7
319	R:R:E204	R:R:V203	8.56	No	No	0	4	3
320	R:R:P207	R:R:V206	3.53	No	No	0	3	3
321	R:R:G209	R:R:V212	3.68	No	No	0	3	3
322	R:R:G209	R:R:R213	4.5	No	No	0	3	2
323	R:R:E210	R:R:R213	3.49	No	No	0	3	2
324	R:R:E210	R:R:R214	10.47	No	No	0	3	4
325	R:R:L211	R:R:R214	3.64	No	No	16	1	4
326	R:R:L211	R:R:P216	4.93	No	Yes	16	1	4
327	R:R:N288	R:R:V212	2.96	No	No	0	4	3
328	R:R:P216	R:R:R214	4.32	Yes	No	16	4	4
329	R:R:D215	R:R:N288	6.73	No	No	0	6	4
330	R:R:P216	R:R:S218	3.56	Yes	No	0	4	3
331	R:R:C219	R:R:P216	5.65	No	Yes	0	9	4
332	R:R:C219	R:R:C289	7.28	No	No	0	9	9
333	R:R:K220	R:R:W290	22.05	No	Yes	0	7	9
334	R:R:F225	R:R:I221	5.02	No	No	0	5	4
335	R:R:H223	R:R:Q227	12.36	No	No	0	5	7
336	R:R:H223	R:R:H277	3.58	No	Yes	0	5	7
337	R:R:H223	R:R:W290	10.58	No	Yes	0	5	9
338	R:R:F224	R:R:T274	9.08	Yes	No	0	5	6
339	R:R:I301	R:R:Q227	9.61	No	No	0	7	7
340	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
341	R:R:L271	R:R:Y228	9.38	No	No	0	4	8
342	R:R:T274	R:R:Y228	4.99	No	No	0	6	8
343	R:R:M230	R:R:Y234	3.59	No	Yes	0	6	7
344	R:R:I301	R:R:M230	2.92	No	No	0	7	6
345	R:R:H302	R:R:M230	5.25	Yes	No	0	6	6
346	R:R:C232	R:R:W267	5.22	No	Yes	0	8	9
347	R:R:C232	R:R:P270	5.65	No	Yes	0	8	9
348	R:R:M237	R:R:N233	4.21	Yes	Yes	2	9	9
349	R:R:M237	R:R:Y234	4.79	Yes	Yes	2	9	7
350	R:R:V305	R:R:Y234	17.66	No	Yes	2	7	7
351	R:R:L309	R:R:Y234	3.52	No	Yes	2	7	7
352	R:R:F356	R:R:Y234	11.35	Yes	Yes	2	7	7
353	R:R:F235	R:R:L265	3.65	Yes	Yes	6	5	7
354	R:R:F235	R:R:F269	6.43	Yes	Yes	6	5	3
355	R:R:F235	R:R:P270	5.78	Yes	Yes	0	5	9
356	R:R:C239	R:R:W236	5.22	No	Yes	0	7	9
357	R:R:G266	R:R:W236	7.04	No	Yes	0	9	9
358	R:R:W236	R:R:W267	15.93	Yes	Yes	2	9	9
359	R:R:M237	R:R:Q383	5.44	Yes	Yes	2	9	9
360	R:R:I242	R:R:L238	7.14	No	No	0	7	8
361	R:R:A308	R:R:L238	6.3	No	No	0	7	8
362	R:R:L238	R:R:V311	2.98	No	No	0	8	6
363	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
364	R:R:G241	R:R:N312	5.09	No	No	0	8	9
365	R:R:F315	R:R:I242	3.77	No	No	0	8	7
366	R:R:L247	R:R:Y243	10.55	No	Yes	0	8	8
367	R:R:Q257	R:R:Y243	5.64	Yes	Yes	9	5	8
368	R:R:Y243	R:R:Y262	5.96	Yes	Yes	9	8	7
369	R:R:I248	R:R:L244	4.28	No	No	0	7	9
370	R:R:H245	R:R:V249	8.3	Yes	Yes	17	8	6
371	R:R:F315	R:R:H245	24.89	No	Yes	0	8	8
372	R:R:H245	R:R:N318	3.83	Yes	No	17	8	8
373	R:R:H245	R:R:I319	3.98	Yes	No	0	8	9
374	R:R:T246	R:R:V250	4.76	No	No	0	7	5
375	R:R:Q257	R:R:T246	4.25	Yes	No	0	5	7
376	R:R:I248	R:R:V249	3.07	No	Yes	0	7	6
377	R:R:I248	R:R:I319	7.36	No	No	0	7	9
378	R:R:N318	R:R:V249	2.96	No	Yes	17	8	6
379	R:R:E255	R:R:K256	4.05	No	No	0	6	5
380	R:R:Q257	R:R:Y262	4.51	Yes	Yes	9	5	7
381	R:R:L259	R:R:Y262	3.52	Yes	Yes	0	5	7
382	R:R:L259	R:R:Y263	7.03	Yes	No	0	5	5
383	R:R:R260	R:R:Y263	4.12	No	No	0	3	5
384	R:R:F269	R:R:P273	4.33	Yes	No	0	3	6
385	R:R:P273	R:R:V272	3.53	No	No	0	6	4
386	R:R:I276	R:R:V272	3.07	No	No	0	5	4
387	R:R:H277	R:R:R281	12.41	Yes	Yes	0	7	7
388	R:R:H277	R:R:I300	3.98	Yes	No	0	7	8
389	R:R:H277	R:R:I301	13.26	Yes	No	0	7	7
390	R:R:L297	R:R:T280	5.9	No	No	0	4	4
391	R:R:F285	R:R:R281	6.41	Yes	Yes	5	6	7
392	R:R:D287	R:R:R281	7.15	Yes	Yes	5	3	7
393	R:R:R281	R:R:W290	15.99	Yes	Yes	5	7	9
394	R:R:R281	R:R:T295	6.47	Yes	No	5	7	4
395	R:R:V283	R:R:Y284	12.62	No	No	0	3	2
396	R:R:D287	R:R:F285	7.17	Yes	Yes	5	3	6
397	R:R:F285	R:R:S292	3.96	Yes	Yes	5	6	4
398	R:R:F285	R:R:T295	9.08	Yes	No	5	6	4
399	R:R:D287	R:R:W290	5.58	Yes	Yes	5	3	9
400	R:R:D287	R:R:S292	4.42	Yes	Yes	5	3	4
401	R:R:C289	R:R:L291	4.76	No	No	0	9	6
402	R:R:E294	R:R:S292	2.87	No	Yes	0	3	4
403	R:R:L298	R:R:V293	2.98	No	No	0	6	6
404	R:R:H302	R:R:L298	10.29	Yes	No	0	6	6
405	R:R:G303	R:R:P304	4.06	No	No	0	4	9
406	R:R:L309	R:R:V305	2.98	No	No	2	7	7
407	R:R:F356	R:R:L309	3.65	Yes	No	2	7	7
408	R:R:F314	R:R:V310	5.24	No	No	0	5	4
409	R:R:F315	R:R:V311	5.24	No	No	0	8	6
410	R:R:L352	R:R:N312	15.1	Yes	No	0	9	9
411	R:R:F313	R:R:F314	4.29	Yes	No	0	6	5
412	R:R:F313	R:R:L317	10.96	Yes	No	0	6	5
413	R:R:F313	R:R:I354	5.02	Yes	Yes	0	6	6
414	R:R:F313	R:R:V357	3.93	Yes	No	0	6	7
415	R:R:L316	R:R:V320	2.98	Yes	No	0	9	7
416	R:R:L316	R:R:L348	4.15	Yes	No	0	9	9
417	R:R:L316	R:R:L352	4.15	Yes	Yes	18	9	9
418	R:R:I354	R:R:L316	7.14	Yes	Yes	18	6	9
419	R:R:N318	R:R:R321	6.03	No	No	0	8	8
420	R:R:K340	R:R:M327	4.32	No	No	0	8	7
421	R:R:E332	R:R:H336	7.39	No	No	0	5	6
422	R:R:E334	R:R:M337	5.41	No	No	0	6	7
423	R:R:E334	R:R:Y338	15.71	No	No	0	6	7
424	R:R:H336	R:R:K340	5.24	No	No	0	6	8
425	R:R:K340	R:R:K343	4.31	No	No	0	8	8
426	R:R:I347	R:R:K343	2.91	No	No	0	8	8
427	R:R:M346	R:R:T345	3.01	No	No	0	8	9
428	R:R:P350	R:R:V349	3.53	No	No	0	9	8
429	R:R:I354	R:R:V349	9.22	Yes	No	0	6	8
430	R:R:L351	R:R:L352	4.15	No	Yes	0	9	9
431	R:R:L351	R:R:Y391	16.41	No	Yes	0	9	8
432	R:R:I354	R:R:L352	4.28	Yes	Yes	18	6	9
433	R:R:F356	R:R:G353	3.01	Yes	No	0	7	9
434	R:R:F356	R:R:Q355	7.03	Yes	No	2	7	8
435	R:R:L379	R:R:Q355	6.65	No	No	0	5	8
436	R:R:Q355	R:R:Q383	12.8	No	Yes	2	8	9
437	R:R:F356	R:R:I380	7.54	Yes	No	0	7	6
438	R:R:F356	R:R:Q383	4.68	Yes	Yes	2	7	9
439	R:R:F359	R:R:V358	11.8	No	No	0	6	5
440	R:R:F359	R:R:Y372	3.09	No	Yes	7	6	7
441	R:R:F359	R:R:M376	3.73	No	Yes	7	6	7
442	R:R:P363	R:R:R362	2.88	Yes	No	7	7	4
443	R:R:R362	R:R:Y372	4.12	No	Yes	7	4	7
444	R:R:D373	R:R:R362	10.72	No	No	7	5	4
445	R:R:L368	R:R:P363	8.21	No	Yes	0	3	7
446	R:R:G369	R:R:P363	6.09	No	Yes	0	4	7
447	R:R:P363	R:R:Y372	9.74	Yes	Yes	7	7	7
448	R:R:L368	R:R:N365	4.12	No	No	0	3	4
449	R:R:I371	R:R:M367	2.92	No	No	0	5	4
450	R:R:K370	R:R:Y374	5.97	No	Yes	14	4	6
451	R:R:D373	R:R:Y372	3.45	No	Yes	7	5	7
452	R:R:M376	R:R:Y372	9.58	Yes	Yes	7	7	7
453	R:R:L379	R:R:V375	2.98	No	No	0	5	4
454	R:R:I380	R:R:M376	5.83	No	Yes	0	6	7
455	R:R:H377	R:R:H381	9.55	No	No	0	7	9
456	R:R:F382	R:R:F386	4.29	No	No	0	7	5
457	R:R:F385	R:R:F386	5.36	No	No	0	5	5
458	R:R:F393	R:R:T389	3.89	No	No	0	8	5
459	R:R:I390	R:R:Y391	7.25	No	Yes	0	8	8
460	R:R:C392	R:R:F393	4.19	Yes	No	0	9	8
461	R:R:N395	R:R:N396	4.09	No	No	19	9	6
462	R:R:E397	R:R:N395	11.83	No	No	19	9	9
463	R:R:N395	R:R:V398	10.35	No	No	0	9	9
464	R:R:E397	R:R:N396	11.83	No	No	19	9	6
465	R:R:Q405	R:R:T401	5.67	No	Yes	10	4	7
466	R:R:Q405	R:R:R404	5.84	No	No	0	4	7
467	R:R:F409	R:R:Q408	19.91	No	No	0	3	7
468	E:E:E30	E:E:V80	2.85	No	Yes	0	7	5
469	E:E:I125	E:E:L129	2.85	No	No	0	5	7
470	E:E:Q90	E:E:T94	2.83	Yes	No	0	9	7
471	R:R:K220	R:R:N286	2.8	No	No	0	7	7
472	L:L:F15	R:R:A145	2.77	Yes	No	0	0	4
473	R:R:D50	R:R:K54	2.77	No	No	0	2	4
474	R:R:D113	R:R:K120	2.77	No	No	0	5	1
475	R:R:A136	R:R:F137	2.77	No	No	0	2	1
476	R:R:L189	R:R:L193	2.77	No	No	0	3	6
477	R:R:H201	R:R:V206	2.77	No	No	0	6	3
478	R:R:A278	R:R:F224	2.77	No	Yes	0	6	5
479	R:R:L244	R:R:L348	2.77	No	No	0	9	9
480	R:R:L211	R:R:N208	2.75	No	No	0	1	3
481	E:E:E74	E:E:M75	2.71	No	No	0	5	1
482	L:L:L27	R:R:D101	2.71	No	Yes	0	0	4
483	R:R:E106	R:R:M133	2.71	No	No	0	4	5
484	R:R:K256	R:R:Q179	2.71	No	Yes	0	5	7
485	R:R:P360	R:R:W361	2.7	No	No	0	5	4
486	L:L:C2	R:R:Y299	2.69	No	No	0	0	7
487	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
488	L:L:S34	R:R:R126	2.64	Yes	No	0	0	4
489	R:R:A51	R:R:W76	2.59	No	Yes	0	8	8
490	R:R:F224	R:R:T275	2.59	Yes	No	0	5	3
491	R:R:H201	R:R:L291	2.57	No	No	0	6	6
492	R:R:V147	R:R:Y374	2.52	No	Yes	0	4	6
493	R:R:F393	R:R:I165	2.51	No	No	0	8	5
494	R:R:F173	R:R:I169	2.51	Yes	No	0	7	8
495	L:L:F15	R:R:K141	2.48	Yes	No	0	0	3
496	R:R:M337	R:R:R328	2.48	No	No	0	7	6
497	E:E:V137	R:R:W261	2.45	No	No	0	9	2
498	E:E:F92	E:E:L88	2.44	No	No	0	8	6
499	E:E:L129	R:R:F269	2.44	No	Yes	0	7	3
500	E:E:L136	E:E:R140	2.43	No	Yes	0	6	8
501	R:R:I347	R:R:Y391	2.42	No	Yes	0	8	8
502	R:R:M48	R:R:Y98	2.39	No	Yes	0	6	4
503	R:R:K107	R:R:Y92	2.39	No	No	0	3	4
504	R:R:D84	R:R:R74	2.38	No	No	0	4	4
505	R:R:E397	R:R:R180	2.33	No	No	0	9	9
506	R:R:F224	R:R:F225	2.14	Yes	No	0	5	5
507	R:R:G116	R:R:P70	2.03	No	No	0	9	1
508	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
509	R:R:R258	R:R:W261	2	No	No	0	5	2
510	E:E:P114	E:E:P115	1.95	Yes	No	0	9	8
511	E:E:A134	E:E:G135	1.95	No	No	0	8	7
512	L:L:P28	L:L:P29	1.95	No	No	0	0	0
513	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
514	E:E:G81	E:E:V80	1.84	No	Yes	0	4	5
515	E:E:G135	E:E:V138	1.84	No	No	0	7	9
516	R:R:G44	R:R:V43	1.84	No	No	0	4	2
517	R:R:G155	R:R:V154	1.84	No	No	0	8	6
518	E:E:G32	E:E:T31	1.82	No	No	0	3	7
519	E:E:G95	E:E:T94	1.82	No	No	0	3	7
520	L:L:G33	L:L:T36	1.82	No	Yes	0	0	0
521	R:R:A87	R:R:C112	1.81	No	No	0	4	9
522	R:R:G44	R:R:K47	1.74	No	No	0	4	4
523	E:E:A77	E:E:V80	1.7	No	Yes	0	7	5
524	E:E:V127	R:R:A307	1.7	No	No	0	7	3
525	E:E:V131	R:R:A307	1.7	No	No	0	6	3
526	L:L:A13	R:R:V206	1.7	No	No	0	0	3
527	R:R:A251	R:R:V250	1.7	No	No	0	6	5
528	R:R:A341	R:R:V324	1.7	No	No	0	9	5
529	L:L:I26	L:L:P28	1.69	No	No	0	0	0
530	R:R:A251	R:R:T254	1.68	No	No	0	6	6
531	R:R:M306	R:R:P360	1.68	No	No	0	4	5
532	R:R:L62	R:R:P63	1.64	No	No	0	3	1
533	R:R:E68	R:R:G69	1.64	No	No	0	1	1
534	R:R:C392	R:R:I169	1.64	Yes	No	0	9	8
535	L:L:N22	R:R:P207	1.63	No	No	0	0	3
536	E:E:S68	E:E:V64	1.62	No	No	0	2	4
537	E:E:C72	E:E:M75	1.62	No	No	0	9	1
538	L:L:A8	R:R:I380	1.62	No	No	0	0	6
539	E:E:V124	E:E:V128	1.6	No	No	0	4	4
540	R:R:V249	R:R:V322	1.6	Yes	No	0	6	8
541	R:R:V320	R:R:V324	1.6	No	No	0	7	5
542	R:R:T345	R:R:V320	1.59	No	No	0	9	7
543	R:R:T345	R:R:V349	1.59	No	No	0	9	8
544	R:R:A344	R:R:L323	1.58	No	No	0	9	9
545	E:E:E35	E:E:P38	1.57	No	No	0	3	5
546	R:R:T400	R:R:T401	1.57	No	Yes	0	4	7
547	E:E:A89	E:E:N86	1.56	No	No	0	8	9
548	R:R:I153	R:R:S157	1.55	No	No	0	7	7
549	R:R:I199	R:R:S157	1.55	No	No	0	7	7
550	E:E:I120	E:E:V124	1.54	No	No	0	5	4
551	R:R:I279	R:R:V283	1.54	No	No	0	3	3
552	R:R:I371	R:R:V375	1.54	No	No	0	5	4
553	E:E:V109	R:R:K54	1.52	No	No	0	5	4
554	R:R:A64	R:R:Q66	1.52	No	No	0	1	1
555	R:R:K185	R:R:V171	1.52	Yes	No	0	6	4
556	R:R:K326	R:R:V322	1.52	No	No	0	9	8
557	R:R:M346	R:R:V342	1.52	No	No	0	8	8
558	R:R:L151	R:R:S378	1.5	No	No	0	5	5
559	L:L:N21	L:L:S20	1.49	No	No	0	0	0
560	R:R:L222	R:R:V205	1.49	No	No	0	6	7
561	R:R:L158	R:R:T162	1.47	No	No	0	4	6
562	R:R:A333	R:R:H336	1.46	No	No	0	5	6
563	R:R:F99	R:R:P100	1.44	Yes	No	0	5	4
564	E:E:M133	R:R:L264	1.41	Yes	No	0	9	3
565	R:R:E329	R:R:T325	1.41	No	No	0	6	7
566	R:R:E332	R:R:T330	1.41	No	No	0	5	5
567	E:E:D116	E:E:I120	1.4	No	No	0	6	5
568	R:R:K143	R:R:N144	1.4	No	No	0	1	4
569	R:R:D50	R:R:K47	1.38	No	No	0	2	4
570	E:E:D116	E:E:L119	1.36	No	No	0	6	9
571	R:R:K403	R:R:Q399	1.36	No	No	0	6	7
572	E:E:D107	R:R:D57	1.33	No	No	0	5	4
573	E:E:E67	E:E:N71	1.31	No	No	0	4	4
574	R:R:R328	R:R:V324	1.31	No	No	0	6	5
575	R:R:A282	R:R:W290	1.3	No	Yes	0	3	9
576	R:R:R321	R:R:T325	1.29	No	No	0	8	7
577	R:R:R328	R:R:T325	1.29	No	No	0	6	7
578	R:R:T109	R:R:Y92	1.25	No	No	0	5	4
579	E:E:H97	R:R:Q60	1.24	Yes	No	0	9	3
580	R:R:M48	R:R:R45	1.24	No	No	0	6	7
581	R:R:F119	R:R:K110	1.24	No	Yes	0	4	8
582	E:E:D107	E:E:R108	1.19	No	No	0	5	4
583	R:R:F94	R:R:Q93	1.17	No	No	0	3	6
584	R:R:L148	R:R:Y374	1.17	No	Yes	0	5	6
585	E:E:Y83	R:R:R126	1.03	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:L37	6.78	4	1	8
2	E:E:C40	4.2175	4	1	9
3	E:E:F44	15.6725	4	1	9
4	E:E:M48	8.174	5	1	9
5	E:E:W56	15.045	6	1	7
6	E:E:E61	9.6	5	1	6
7	E:E:F62	11.7175	4	1	8
8	E:E:Y65	9.56286	7	1	5
9	E:E:Y66	8.63875	8	1	9
10	E:E:F69	8.624	5	1	8
11	E:E:E76	8.8775	4	1	6
12	E:E:V80	5.688	5	0	5
13	E:E:Q90	4.49	4	0	9
14	E:E:I93	5.925	4	1	9
15	E:E:H97	6.218	5	1	9
16	E:E:F101	11.212	5	1	9
17	E:E:V106	6.01	4	1	4
18	E:E:P114	5.274	5	0	9
19	E:E:M133	4.08	4	6	9
20	E:E:R140	8.605	4	0	8
21	L:L:T6	5.32333	6	2	0
22	L:L:F15	5.1725	4	0	0
23	L:L:S34	4.2375	4	8	0
24	L:L:T36	6.5	4	3	0
25	R:R:Q52	12.5375	4	1	6
26	R:R:Y53	14.91	4	1	1
27	R:R:Y56	9.55	6	1	3
28	R:R:Y71	10.305	4	4	3
29	R:R:W76	9.25	5	1	8
30	R:R:W79	7.12333	6	3	6
31	R:R:L80	7.4125	4	3	5
32	R:R:W82	6.4	7	3	9
33	R:R:T85	4.15	4	4	7
34	R:R:C95	3.9225	4	0	9
35	R:R:P96	7.395	4	0	9
36	R:R:Y98	5.02667	6	3	4
37	R:R:F99	4.67	5	3	5
38	R:R:D101	7.27	4	0	4
39	R:R:F102	4.71	6	3	4
40	R:R:V108	5.0425	4	3	7
41	R:R:K110	10.7275	4	3	8
42	R:R:W118	10.206	5	3	9
43	R:R:H121	8.6025	4	8	4
44	R:R:Y131	9.9175	4	3	5
45	R:R:Y149	6.8925	4	12	5
46	R:R:L163	4.5525	4	0	8
47	R:R:F170	5.43	4	15	8
48	R:R:F173	6.38667	6	10	7
49	R:R:Q179	7.0025	4	9	7
50	R:R:V181	4.83	4	15	9
51	R:R:H184	6.6575	4	0	9
52	R:R:K185	3.4375	4	15	6
53	R:R:Y191	6.74429	7	2	8
54	R:R:P216	4.615	4	16	4
55	R:R:F224	4.145	4	0	5
56	R:R:N233	7.175	4	2	9
57	R:R:Y234	8.275	6	2	7
58	R:R:F235	6.235	4	6	5
59	R:R:W236	7.96857	7	2	9
60	R:R:M237	4.424	5	2	9
61	R:R:Y243	6.49	6	9	8
62	R:R:H245	10.25	4	17	8
63	R:R:V249	3.9825	4	17	6
64	R:R:Q257	5.86	5	9	5
65	R:R:L259	6.37	4	0	5
66	R:R:Y262	5.7225	4	9	7
67	R:R:L265	4.6325	4	6	7
68	R:R:W267	7.9325	4	2	9
69	R:R:F269	5.182	5	6	3
70	R:R:P270	3.8325	4	0	9
71	R:R:H277	8.3075	4	0	7
72	R:R:R281	9.686	5	5	7
73	R:R:F285	7.76	5	5	6
74	R:R:D287	6.08	4	5	3
75	R:R:W290	11.1	5	5	9
76	R:R:S292	3.53	4	5	4
77	R:R:H302	7.142	5	0	6
78	R:R:F313	6.05	4	0	6
79	R:R:L316	4.605	4	18	9
80	R:R:L352	6.92	4	18	9
81	R:R:I354	6.415	4	18	6
82	R:R:F356	5.8375	8	2	7
83	R:R:P363	6.73	4	7	7
84	R:R:Y372	5.996	5	7	7
85	R:R:Y374	5.3225	4	14	6
86	R:R:M376	5.9925	4	7	7
87	R:R:Q383	7.985	4	2	9
88	R:R:Y391	7.61	4	0	8
89	R:R:C392	4.2275	4	0	9
90	R:R:T401	5.1425	4	10	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:E76	E:E:T73	13.3013	7.06	Yes	No	1	6	9
2	E:E:F69	E:E:T73	26.5963	11.67	Yes	No	1	8	9
3	E:E:F69	E:E:Y66	19.5393	6.19	Yes	Yes	1	8	9
4	E:E:Y66	R:R:Q52	18.1253	11.27	Yes	Yes	1	9	6
5	E:E:Y66	R:R:Y56	18.1976	5.96	Yes	Yes	1	9	3
6	E:E:I93	R:R:Y56	11.6121	4.84	Yes	Yes	1	9	3
7	R:R:A51	R:R:Y98	55.9426	2.67	No	Yes	0	8	4
8	R:R:A51	R:R:W76	55.6751	2.59	No	Yes	0	8	8
9	R:R:Q52	R:R:W76	18.7164	16.43	Yes	Yes	1	6	8
10	R:R:W76	R:R:Y56	35.878	9.65	Yes	Yes	1	8	3
11	R:R:P96	R:R:Y98	58.07	8.34	Yes	Yes	0	9	4
12	R:R:C95	R:R:P96	66.453	3.77	Yes	Yes	0	9	9
13	R:R:C95	R:R:E106	92.2578	3.04	Yes	No	0	9	4
14	R:R:D103	R:R:E106	92.59	7.8	No	No	0	3	4
15	R:R:D103	R:R:S105	99.5685	4.42	No	No	0	3	1
16	L:L:K1	R:R:S105	99.7128	6.12	No	No	0	0	1
17	L:L:K1	R:R:E294	99.8566	6.75	No	No	0	0	3
18	R:R:E294	R:R:S292	100	2.87	No	Yes	0	3	4
19	R:R:F285	R:R:S292	23.9507	3.96	Yes	Yes	5	6	4
20	R:R:F285	R:R:R281	21.9711	6.41	Yes	Yes	5	6	7
21	R:R:H277	R:R:R281	44.6947	12.41	Yes	Yes	0	7	7
22	R:R:D287	R:R:S292	22.4984	4.42	Yes	Yes	5	3	4
23	R:R:D287	R:R:R281	21.8423	7.15	Yes	Yes	5	3	7
24	L:L:E14	R:R:S292	54.1514	2.87	No	Yes	0	0	4
25	L:L:E14	R:R:V293	54.5603	7.13	No	No	0	0	6
26	R:R:L298	R:R:V293	54.5741	2.98	No	No	0	6	6
27	R:R:H302	R:R:L298	54.5926	10.29	Yes	No	0	6	6
28	L:L:T6	R:R:H302	31.9237	6.85	Yes	Yes	0	0	6
29	L:L:T6	R:R:Y234	23.1093	8.74	Yes	Yes	2	0	7
30	R:R:M237	R:R:Y234	90.9971	4.79	Yes	Yes	2	9	7
31	R:R:M187	R:R:M237	65.1663	2.89	No	Yes	2	8	9
32	R:R:M187	R:R:W236	66.2395	3.49	No	Yes	2	8	9
33	R:R:C239	R:R:W236	15.1838	5.22	No	Yes	0	7	9
34	R:R:C239	R:R:L265	14.715	4.76	No	Yes	0	7	7
35	R:R:H302	R:R:M230	22.9928	5.25	Yes	No	0	6	6
36	R:R:M230	R:R:Y234	68.1664	3.59	No	Yes	0	6	7
37	R:R:H277	R:R:I301	45.5097	13.26	Yes	No	0	7	7
38	R:R:I301	R:R:M230	45.7326	2.92	No	No	0	7	6
39	R:R:L183	R:R:W236	44.5252	4.56	No	Yes	0	8	9
40	R:R:E240	R:R:L183	35.4292	5.3	No	No	0	9	8
41	R:R:E240	R:R:H184	34.9918	9.85	No	Yes	0	9	9
42	R:R:H184	R:R:Y391	32.4329	4.36	Yes	Yes	0	9	8
43	R:R:L351	R:R:Y391	27.8758	16.41	No	Yes	0	9	8
44	R:R:L351	R:R:L352	27.4173	4.15	No	Yes	0	9	9
45	R:R:L316	R:R:L352	20.8302	4.15	Yes	Yes	18	9	9
46	R:R:L316	R:R:L348	14.2968	4.15	Yes	No	0	9	9
47	R:R:L244	R:R:L348	13.8255	2.77	No	No	0	9	9
48	R:R:I248	R:R:L244	13.3547	4.28	No	No	0	7	9
49	L:L:T36	R:R:W79	17.0054	6.06	Yes	Yes	3	0	6
50	L:L:N31	L:L:T36	15.0303	14.62	No	Yes	0	0	0
51	L:L:N31	L:L:N35	13.9598	4.09	No	No	0	0	0
52	L:L:N35	L:L:S34	12.8887	2.98	No	Yes	0	0	0
53	R:R:D103	R:R:P104	14.4081	4.83	No	No	0	3	3
54	L:L:H18	R:R:P104	13.7729	6.1	No	No	0	0	3
55	L:L:H18	L:L:S19	13.4545	5.58	No	No	0	0	0
56	L:L:F15	L:L:S19	13.1357	10.57	Yes	No	0	0	0
57	L:L:F15	R:R:L142	11.213	4.87	Yes	No	0	0	2
58	R:R:V108	R:R:W82	14.8701	3.68	Yes	Yes	3	7	9
59	R:R:C95	R:R:V108	19.3659	3.42	Yes	Yes	0	9	7
60	R:R:M237	R:R:Y191	19.6864	4.79	Yes	Yes	2	9	8
61	R:R:L163	R:R:Y191	23.3353	4.69	Yes	Yes	0	8	8
62	R:R:F188	R:R:L163	14.8399	6.09	No	Yes	0	8	8
63	R:R:F188	R:R:S166	14.3099	6.61	No	No	0	8	9
64	R:R:C392	R:R:S166	13.7846	6.89	Yes	No	0	9	9
65	R:R:C232	R:R:W267	11.0762	5.22	No	Yes	0	8	9
66	E:E:C40	E:E:T73	12.3512	3.38	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?501	R:R:W128	6.13	8	No	No	0	5	2	2
H:H:?501	R:R:T132	6.61	8	No	No	0	6	2	1
L:L:K1	R:R:S105	6.12	0	No	No	0	1	0	1
L:L:K1	R:R:E294	6.75	0	No	No	0	3	0	1
L:L:N3	R:R:W361	10.17	0	No	No	0	4	0	1
L:L:T4	R:R:M306	4.52	2	No	No	0	4	0	1
L:L:A5	R:R:F356	5.55	0	No	Yes	0	7	0	1
L:L:A5	R:R:M376	4.83	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	8.74	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	6.85	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	3.17	2	Yes	No	0	7	0	1
L:L:T6	R:R:M306	3.01	2	Yes	No	0	4	0	1
L:L:T6	R:R:F356	3.89	2	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	5.9	0	No	Yes	0	6	0	1
L:L:T9	R:R:I198	4.56	0	No	No	0	7	0	1
L:L:Q10	R:R:H302	7.42	0	No	Yes	0	6	0	1
L:L:L12	R:R:H377	5.14	0	No	No	0	7	0	1
L:L:E14	R:R:S292	2.87	0	No	Yes	0	4	0	1
L:L:E14	R:R:V293	7.13	0	No	No	0	6	0	1
L:L:F15	R:R:L142	4.87	0	Yes	No	0	2	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:R17	R:R:L291	7.29	0	No	No	0	6	0	1
L:L:H18	R:R:P104	6.1	0	No	No	0	3	0	1
L:L:S20	R:R:L142	3	11	No	No	0	2	0	1
L:L:S20	R:R:Y146	6.36	11	No	No	0	2	0	1
L:L:F23	R:R:Y146	21.66	0	No	No	0	2	0	1
L:L:F23	R:R:Y150	4.13	0	No	No	0	4	0	1
L:L:T30	R:R:F99	6.49	3	No	Yes	0	5	0	1
L:L:T30	R:R:D101	8.67	3	No	Yes	0	4	0	1
L:L:T30	R:R:F102	6.49	3	No	Yes	0	4	0	1
L:L:V32	R:R:T132	6.35	0	No	No	0	6	0	1
L:L:S34	R:R:H121	5.58	8	Yes	Yes	0	4	0	1
L:L:S34	R:R:E123	5.75	8	Yes	No	0	4	0	1
L:L:T36	R:R:W79	6.06	3	Yes	Yes	0	6	0	1
L:L:P37	R:R:D77	3.22	3	No	No	0	9	0	1
L:L:P37	R:R:W79	5.4	3	No	Yes	0	6	0	1
R:R:D77	R:R:W82	10.05	0	No	Yes	9	9	1	2
R:R:D77	R:R:Y131	6.9	0	No	Yes	9	5	1	2
R:R:W79	R:R:Y98	5.79	3	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	6.01	3	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	3	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	14.47	3	Yes	Yes	6	5	1	2
R:R:P96	R:R:Y98	8.34	0	Yes	Yes	9	4	2	2
R:R:F102	R:R:P96	4.33	3	Yes	Yes	4	9	1	2
R:R:D97	R:R:P104	4.83	0	No	No	2	3	2	1
R:R:F99	R:R:Y98	6.19	3	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	3.22	3	Yes	Yes	4	5	1	1
R:R:D101	R:R:N135	14.81	0	Yes	No	4	3	1	2
R:R:D101	R:R:T138	2.89	0	Yes	No	4	2	1	2
R:R:C134	R:R:F102	5.59	0	No	Yes	9	4	2	1
R:R:F102	R:R:N135	3.62	3	Yes	No	4	3	1	2
R:R:D103	R:R:P104	4.83	0	No	No	3	3	2	1
R:R:D103	R:R:S105	4.42	0	No	No	3	1	2	1
R:R:H121	R:R:P122	6.1	8	Yes	No	4	5	1	2
R:R:E123	R:R:H121	3.69	8	No	Yes	4	4	1	1
R:R:H121	R:R:W128	19.04	8	Yes	No	4	5	1	2
R:R:N124	R:R:R126	25.31	0	No	No	5	4	2	1
R:R:F137	R:R:K141	4.96	13	No	No	1	3	2	1
R:R:F137	R:R:K366	9.93	13	No	No	1	3	2	2
R:R:K141	R:R:K366	4.31	13	No	No	3	3	1	2
R:R:L142	R:R:Y146	11.72	11	No	No	2	2	1	1
R:R:H377	R:R:L148	18	0	No	No	7	5	1	2
R:R:Y149	R:R:Y150	4.96	12	Yes	No	5	4	1	1
R:R:I153	R:R:Y149	10.88	12	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	8.21	12	No	Yes	7	5	2	1
R:R:I153	R:R:L202	5.71	12	No	No	7	7	2	2
R:R:H156	R:R:I198	10.61	0	No	No	7	7	2	1
R:R:H156	R:R:H381	9.55	0	No	No	7	9	2	2
R:R:H226	R:R:I198	5.3	0	No	No	6	7	2	1
R:R:P207	R:R:V206	3.53	0	No	No	3	3	1	1
R:R:M230	R:R:Y234	3.59	0	No	Yes	6	7	2	1
R:R:H302	R:R:M230	5.25	0	Yes	No	6	6	1	2
R:R:M237	R:R:Y234	4.79	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	17.66	2	No	Yes	7	7	1	1
R:R:L309	R:R:Y234	3.52	2	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	11.35	2	Yes	Yes	7	7	1	1
R:R:M237	R:R:Q383	5.44	2	Yes	Yes	9	9	2	2
R:R:D287	R:R:F285	7.17	5	Yes	Yes	3	6	2	2
R:R:F285	R:R:S292	3.96	5	Yes	Yes	6	4	2	1
R:R:D287	R:R:S292	4.42	5	Yes	Yes	3	4	2	1
R:R:C289	R:R:L291	4.76	0	No	No	9	6	2	1
R:R:E294	R:R:S292	2.87	0	No	Yes	3	4	1	1
R:R:L298	R:R:V293	2.98	0	No	No	6	6	2	1
R:R:H302	R:R:L298	10.29	0	Yes	No	6	6	1	2
R:R:L309	R:R:V305	2.98	2	No	No	7	7	2	1
R:R:F356	R:R:L309	3.65	2	Yes	No	7	7	1	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	7.03	2	Yes	No	7	8	1	2
R:R:Q355	R:R:Q383	12.8	2	No	Yes	8	9	2	2
R:R:F356	R:R:I380	7.54	2	Yes	No	7	6	1	1
R:R:F356	R:R:Q383	4.68	2	Yes	Yes	7	9	1	2
R:R:F359	R:R:Y372	3.09	7	No	Yes	6	7	2	2
R:R:F359	R:R:M376	3.73	7	No	Yes	6	7	2	1
R:R:M376	R:R:Y372	9.58	7	Yes	Yes	7	7	1	2
R:R:I380	R:R:M376	5.83	0	No	Yes	6	7	1	1
R:R:H377	R:R:H381	9.55	0	No	No	7	9	1	2
L:L:F15	R:R:A145	2.77	0	Yes	No	0	4	0	1
R:R:H201	R:R:V206	2.77	0	No	No	6	3	2	1
L:L:L27	R:R:D101	2.71	0	No	Yes	0	4	0	1
R:R:P360	R:R:W361	2.7	0	No	No	5	4	2	1
L:L:C2	R:R:Y299	2.69	0	No	No	0	7	0	1
L:L:S34	R:R:R126	2.64	8	Yes	No	0	4	0	1
R:R:H201	R:R:L291	2.57	0	No	No	6	6	2	1
L:L:F15	R:R:K141	2.48	0	Yes	No	0	3	0	1
L:L:A13	R:R:V206	1.7	0	No	No	0	3	0	1
R:R:M306	R:R:P360	1.68	2	No	No	4	5	1	2
L:L:N22	R:R:P207	1.63	0	No	No	0	3	0	1
L:L:A8	R:R:I380	1.62	0	No	No	0	6	0	1
R:R:F99	R:R:P100	1.44	3	Yes	No	5	4	1	2
E:E:Y83	R:R:R126	1.03	0	No	No	6	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BTW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.87
Number of Linked Nodes	497
Number of Links	585
Number of Hubs	90
Number of Links mediated by Hubs	316
Number of Communities	19
Number of Nodes involved in Communities	124
Number of Links involved in Communities	175

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	578127
Length Of Smallest Path	3
Average Path Length	25.3174
Length of Longest Path	50
Minimum Path Strength	1.26
Average Path Strength	6.0055
Maximum Path Strength	20.61
Minimum Path Correlation	0.7
Average Path Correlation	0.967267
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	51.1729
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0509
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of protein localization to plasma membrane • regulation of localization • cellular localization • regulation of protein localization • intracellular protein localization • regulation of protein localization to membrane • positive regulation of protein localization to cell periphery • protein localization to cell periphery • protein localization to plasma membrane • positive regulation of protein localization to membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of protein localization to plasma membrane • establishment of protein localization • protein transport • regulation of signaling receptor activity • negative regulation of molecular function • regulation of molecular function • cross-receptor inhibition within G protein-coupled receptor heterodimer • G protein-coupled receptor signaling pathway • negative regulation of signaling receptor activity • regulation of G protein-coupled receptor signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of receptor recycling • receptor recycling • receptor metabolic process • positive regulation of receptor recycling • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • heart process • multicellular organismal process • system process • circulatory system process • G protein-coupled receptor signaling pathway involved in heart process • intracellular transport • establishment of localization in cell • intracellular protein transport • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • amylin receptor signaling pathway • response to lipid • cellular response to oxygen-containing compound • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex
Gene Ontology	Cellular Component	• cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • lytic vacuole • vacuole • cytoplasm • intracellular membrane-bounded organelle • lysosome • amylin receptor complex • amylin receptor complex 3 • protein binding • binding • signaling receptor binding • amyloid-beta binding • peptide binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • multicellular organismal process • eating behavior • feeding behavior • cell-cell signaling • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • regulation of primary metabolic process • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of supramolecular fiber organization • metabolic process • macromolecule metabolic process • supramolecular fiber organization • regulation of metabolic process • amylin receptor 3 signaling pathway • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • regulation of biosynthetic process • mRNA catabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • regulation of mRNA metabolic process • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?501 H:H:?502
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP3
UniProt	O60896
Sequence	>9BTW_nogp_Chain_E E T G M L E R L P L C G K A F A D M M G K V D V W K W C N L S E F I V Y Y E S F T N C T E M E A N V V G C Y W P N P L A Q G F I T G I H R Q F F S N C T V D R V H L E D P P D E V L I P L I V I P V V L T V A M A G L V V W R S K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Cagrilintide
UniProt	P10997
Sequence	>9BTW_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>9BTW_nogp_Chain_R Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9BTW_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.