psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C28	E:E:C82	7.28	No	Yes	0	9	9
2	E:E:N29	E:E:V80	8.87	No	Yes	0	8	5
3	E:E:M33	E:E:V80	4.56	No	Yes	0	8	5
4	E:E:F92	E:E:L37	28.01	No	No	0	8	8
5	E:E:F92	E:E:P38	7.22	No	No	0	8	5
6	E:E:C40	E:E:C72	7.28	No	No	0	9	9
7	E:E:F44	E:E:M48	7.46	Yes	No	1	9	9
8	E:E:F44	E:E:F62	4.29	Yes	Yes	1	9	8
9	E:E:F44	E:E:Y66	5.16	Yes	No	1	9	9
10	E:E:F44	E:E:F69	13.93	Yes	Yes	0	9	8
11	E:E:F101	E:E:F44	4.29	Yes	Yes	1	9	9
12	E:E:D46	E:E:K50	8.3	No	No	0	1	3
13	E:E:K50	E:E:M47	4.32	No	No	0	3	4
14	E:E:M47	E:E:Y65	13.17	No	No	0	4	5
15	E:E:M48	E:E:W56	19.78	No	No	0	9	7
16	E:E:F62	E:E:M48	8.71	Yes	No	1	8	9
17	E:E:D52	E:E:W54	35.74	No	No	10	6	3
18	E:E:D52	E:E:K55	8.3	No	No	10	6	4
19	E:E:V53	E:E:W56	15.94	No	No	0	4	7
20	E:E:K55	E:E:W54	4.64	No	No	10	4	3
21	E:E:E61	E:E:K55	12.15	No	No	0	6	4
22	E:E:C104	E:E:C57	7.28	No	No	0	9	9
23	E:E:N58	E:E:S60	8.94	No	No	0	8	7
24	E:E:E61	E:E:N58	9.2	No	No	0	6	8
25	E:E:L59	R:R:Y53	4.69	No	Yes	0	7	1
26	E:E:F62	E:E:Y66	6.19	Yes	No	1	8	9
27	E:E:F101	E:E:F62	5.36	Yes	Yes	1	9	8
28	E:E:I63	R:R:K46	8.72	No	No	0	6	4
29	E:E:Y66	R:R:Y53	9.93	No	Yes	1	9	1
30	E:E:E67	R:R:R45	15.12	No	Yes	1	4	7
31	E:E:E67	R:R:M49	12.18	No	Yes	1	4	4
32	E:E:F69	E:E:T73	7.78	Yes	No	0	8	9
33	E:E:F69	E:E:I96	3.77	Yes	No	0	8	6
34	E:E:T70	R:R:M49	6.02	No	Yes	0	9	4
35	E:E:T70	R:R:Q52	11.34	No	Yes	0	9	6
36	E:E:N71	R:R:R45	4.82	No	Yes	0	4	7
37	E:E:I93	E:E:T73	6.08	No	No	0	9	9
38	E:E:E74	E:E:W84	18.54	No	Yes	1	5	9
39	E:E:E74	L:L:Y37	4.49	No	Yes	1	5	0
40	E:E:C82	E:E:N86	4.72	Yes	No	0	9	9
41	E:E:Y83	R:R:R126	19.55	No	No	0	6	4
42	E:E:P85	E:E:W84	6.76	No	Yes	0	9	9
43	E:E:W84	L:L:Y37	5.79	Yes	Yes	1	9	0
44	E:E:W84	R:R:Q52	6.57	Yes	Yes	1	9	6
45	E:E:Q90	R:R:Y56	7.89	No	Yes	1	9	3
46	E:E:Q90	R:R:M59	8.16	No	Yes	1	9	5
47	E:E:I93	R:R:Y56	13.3	No	Yes	0	9	3
48	E:E:F101	E:E:H97	15.84	Yes	Yes	1	9	9
49	E:E:H97	R:R:Y53	8.71	Yes	Yes	1	9	1
50	E:E:H97	R:R:Y56	5.44	Yes	Yes	1	9	3
51	E:E:H97	R:R:Q60	12.36	Yes	No	0	9	3
52	E:E:F100	E:E:Q99	23.42	No	No	0	8	4
53	E:E:F101	R:R:Y53	15.47	Yes	Yes	1	9	1
54	E:E:V106	R:R:D57	4.38	No	No	0	4	4
55	E:E:V106	R:R:Q61	14.33	No	No	0	4	3
56	E:E:D107	E:E:H110	5.04	No	No	0	5	4
57	E:E:R108	R:R:K54	11.14	No	No	0	4	4
58	E:E:L111	R:R:F285	14.61	No	Yes	0	4	6
59	E:E:D113	E:E:P114	4.83	No	Yes	0	9	9
60	E:E:D113	R:R:T295	8.67	No	Yes	0	9	4
61	E:E:D113	R:R:H296	6.3	No	No	0	9	2
62	E:E:P114	R:R:Y284	23.64	Yes	No	0	9	2
63	E:E:P114	R:R:L297	4.93	Yes	No	0	9	4
64	E:E:I123	E:E:L119	4.28	No	No	0	9	9
65	E:E:L119	R:R:H296	5.14	No	No	0	9	2
66	E:E:L122	R:R:T280	4.42	No	No	11	9	4
67	E:E:L122	R:R:I300	4.28	No	No	11	9	8
68	E:E:T130	R:R:F235	7.78	No	Yes	12	9	5
69	E:E:T130	R:R:F269	6.49	No	Yes	12	9	3
70	E:E:T130	R:R:P304	5.25	No	Yes	0	9	9
71	E:E:M133	R:R:L264	4.24	No	No	0	9	3
72	E:E:M133	R:R:F269	7.46	No	Yes	0	9	3
73	E:E:G135	E:E:V138	3.68	No	No	0	7	9
74	E:E:L136	R:R:W261	5.69	No	Yes	0	6	2
75	E:E:V137	R:R:I242	6.14	No	Yes	5	9	7
76	E:E:V137	R:R:W261	3.68	No	Yes	5	9	2
77	E:E:V137	R:R:Y262	6.31	No	Yes	5	9	7
78	E:E:R140	E:E:W139	9	No	No	0	8	9
79	E:E:R140	E:E:R143	9.6	No	No	0	8	8
80	E:E:R140	R:R:W261	13	No	Yes	0	8	2
81	E:E:S141	R:R:Q257	5.78	No	Yes	5	9	5
82	E:E:S141	R:R:Y262	5.09	No	Yes	5	9	7
83	E:E:K142	R:R:A251	4.82	No	No	0	8	6
84	E:E:T144	R:R:R258	3.88	No	No	0	7	5
85	H:H:?1	R:R:Y71	12.62	No	No	0	0	3
86	H:H:?1	R:R:N73	34.5	No	No	0	0	4
87	H:H:?2	R:R:N125	27.11	No	No	0	0	7
88	H:H:?3	R:R:W128	5.11	Yes	Yes	3	0	5
89	H:H:?3	R:R:N130	27.11	Yes	Yes	3	0	8
90	H:H:?3	R:R:T132	6.61	Yes	No	3	0	6
91	H:H:?3	R:R:M133	5.07	Yes	No	0	0	5
92	L:L:K1	L:L:R11	3.71	No	No	0	0	0
93	L:L:K1	R:R:E294	9.45	No	No	0	0	3
94	L:L:C2	L:L:T4	5.07	No	Yes	2	0	0
95	L:L:C2	L:L:C7	7.28	No	No	2	0	0
96	L:L:C2	R:R:Y299	5.38	No	No	2	0	7
97	L:L:N3	R:R:W361	18.08	No	No	0	0	4
98	L:L:N3	R:R:R362	6.03	No	Yes	0	0	4
99	L:L:C7	L:L:T4	5.07	No	Yes	2	0	0
100	L:L:T4	R:R:Y299	4.99	Yes	No	2	0	7
101	L:L:T6	R:R:Y234	8.74	Yes	Yes	2	0	7
102	L:L:T6	R:R:H302	8.21	Yes	Yes	2	0	6
103	L:L:T6	R:R:V305	4.76	Yes	No	2	0	7
104	L:L:T6	R:R:F356	3.89	Yes	Yes	2	0	7
105	L:L:C7	R:R:H302	10.32	No	Yes	2	0	6
106	L:L:A8	R:R:H377	4.39	No	Yes	0	0	7
107	L:L:T9	R:R:H381	6.85	No	Yes	0	0	9
108	L:L:Q10	R:R:H226	6.18	No	No	0	0	6
109	L:L:Q10	R:R:M230	4.08	No	No	2	0	6
110	L:L:Q10	R:R:H302	6.18	No	Yes	2	0	6
111	L:L:R11	R:R:V293	3.92	No	No	0	0	6
112	L:L:L12	L:L:L16	4.15	No	Yes	0	0	0
113	L:L:L12	R:R:L148	4.15	No	Yes	6	0	5
114	L:L:L12	R:R:H377	3.86	No	Yes	6	0	7
115	L:L:H18	L:L:N14	8.93	No	No	0	0	0
116	L:L:N14	R:R:V293	5.91	No	No	0	0	6
117	L:L:F15	L:L:L16	3.65	Yes	Yes	0	0	0
118	L:L:F15	L:L:S19	7.93	Yes	No	0	0	0
119	L:L:F15	R:R:D103	7.17	Yes	Yes	8	0	3
120	L:L:F15	R:R:K141	6.2	Yes	Yes	8	0	3
121	L:L:F23	L:L:L16	3.65	No	Yes	0	0	0
122	L:L:L16	R:R:Y149	4.69	Yes	Yes	0	0	5
123	L:L:V17	R:R:V206	4.81	No	No	0	0	3
124	L:L:V17	R:R:L291	5.96	No	No	0	0	6
125	L:L:H18	R:R:P104	12.2	No	No	0	0	3
126	L:L:N22	L:L:S19	5.96	No	No	0	0	0
127	L:L:F23	L:L:K21	6.2	No	Yes	0	0	0
128	L:L:?101	L:L:K21	14.68	Yes	Yes	7	0	0
129	L:L:K21	R:R:Y149	8.36	Yes	Yes	7	0	5
130	L:L:K21	R:R:P207	13.38	Yes	No	7	0	3
131	L:L:N22	R:R:L142	6.87	No	No	0	0	2
132	L:L:F23	R:R:Y146	19.6	No	No	0	0	2
133	L:L:G24	L:L:P25	4.06	No	No	0	0	0
134	L:L:L27	L:L:P28	4.93	No	No	0	0	0
135	L:L:T30	R:R:F99	14.27	No	Yes	1	0	5
136	L:L:T30	R:R:D101	8.67	No	No	1	0	4
137	L:L:T30	R:R:F102	6.49	No	Yes	1	0	4
138	L:L:N31	L:L:T36	5.85	No	No	0	0	0
139	L:L:V32	R:R:N135	5.91	No	No	0	0	3
140	L:L:S34	R:R:H121	12.55	No	Yes	3	0	4
141	L:L:S34	R:R:E123	8.62	No	No	3	0	4
142	L:L:S34	R:R:N124	5.96	No	No	3	0	5
143	L:L:?38	L:L:Y37	5.8	No	Yes	0	0	0
144	L:L:Y37	R:R:G78	11.59	Yes	No	0	0	5
145	L:L:Y37	R:R:W79	13.5	Yes	Yes	1	0	6
146	L:L:?38	R:R:W128	5.64	No	Yes	0	0	5
147	L:L:?38	R:R:S129	7.43	No	Yes	0	0	7
148	L:L:?101	R:R:Y149	6.66	Yes	Yes	7	0	5
149	L:L:?101	R:R:Y150	4.44	Yes	No	7	0	4
150	L:L:?101	R:R:I153	5.4	Yes	No	0	0	7
151	L:L:?101	R:R:S157	11.37	Yes	No	0	0	7
152	L:L:?101	R:R:I160	5.4	Yes	No	0	0	5
153	L:L:?101	R:R:F161	5.76	Yes	No	0	0	4
154	L:L:?101	R:R:V164	5.64	Yes	No	0	0	4
155	L:L:?101	R:R:V203	7.05	Yes	No	0	0	3
156	L:L:?101	R:R:P207	9.32	Yes	No	7	0	3
157	R:R:P100	R:R:Y41	9.74	No	No	0	4	3
158	R:R:M48	R:R:R45	3.72	Yes	Yes	1	6	7
159	R:R:M49	R:R:R45	4.96	Yes	Yes	1	4	7
160	R:R:D50	R:R:K46	11.06	No	No	0	2	4
161	R:R:M48	R:R:M49	4.33	Yes	Yes	1	6	4
162	R:R:M48	R:R:W79	5.82	Yes	Yes	1	6	6
163	R:R:M48	R:R:Y98	14.37	Yes	Yes	1	6	4
164	R:R:Q52	R:R:Y56	4.51	Yes	Yes	1	6	3
165	R:R:Q52	R:R:W76	20.81	Yes	No	1	6	8
166	R:R:C55	R:R:M59	4.86	No	Yes	0	9	5
167	R:R:C55	R:R:W76	10.45	No	No	0	9	8
168	R:R:C55	R:R:C81	7.28	No	No	0	9	9
169	R:R:M59	R:R:Y56	4.79	Yes	Yes	1	5	3
170	R:R:W76	R:R:Y56	4.82	No	Yes	1	8	3
171	R:R:L62	R:R:R58	9.72	No	No	0	3	3
172	R:R:D83	R:R:R58	14.29	No	No	0	5	3
173	R:R:M59	R:R:R74	9.93	Yes	No	0	5	4
174	R:R:L62	R:R:P63	4.93	No	No	0	3	1
175	R:R:Y65	R:R:Y71	19.86	Yes	No	13	3	3
176	R:R:D84	R:R:Y65	5.75	No	Yes	13	4	3
177	R:R:P86	R:R:Y65	4.17	No	Yes	0	2	3
178	R:R:G67	R:R:Q66	4.93	No	No	0	2	1
179	R:R:G69	R:R:P70	4.06	No	No	0	1	1
180	R:R:D84	R:R:Y71	5.75	No	No	13	4	3
181	R:R:C112	R:R:C72	7.28	No	No	0	9	9
182	R:R:C72	R:R:W118	18.28	No	Yes	0	9	9
183	R:R:D84	R:R:R74	22.63	No	No	0	4	4
184	R:R:K110	R:R:T75	6.01	Yes	No	1	8	5
185	R:R:T75	R:R:W118	8.49	No	Yes	1	5	9
186	R:R:D77	R:R:L80	4.07	Yes	Yes	1	9	5
187	R:R:D77	R:R:W82	10.05	Yes	Yes	0	9	9
188	R:R:D77	R:R:S129	5.89	Yes	Yes	1	9	7
189	R:R:D77	R:R:Y131	8.05	Yes	Yes	1	9	5
190	R:R:W79	R:R:Y98	6.75	Yes	Yes	1	6	4
191	R:R:F99	R:R:W79	10.02	Yes	Yes	1	5	6
192	R:R:W79	R:R:Y131	14.47	Yes	Yes	1	6	5
193	R:R:L80	R:R:Q93	17.3	Yes	No	0	5	6
194	R:R:L80	R:R:P96	11.49	Yes	Yes	1	5	9
195	R:R:L80	R:R:V108	4.47	Yes	No	1	5	7
196	R:R:L80	R:R:Y131	9.38	Yes	Yes	1	5	5
197	R:R:S91	R:R:W82	3.71	No	Yes	0	5	9
198	R:R:Q93	R:R:W82	12.05	No	Yes	0	6	9
199	R:R:V108	R:R:W82	4.9	No	Yes	0	7	9
200	R:R:K110	R:R:W82	19.73	Yes	Yes	0	8	9
201	R:R:S91	R:R:T85	6.4	No	No	0	5	7
202	R:R:T85	R:R:W118	6.06	No	Yes	0	7	9
203	R:R:G88	R:R:Y111	4.35	No	Yes	0	8	4
204	R:R:L90	R:R:Y92	5.86	No	No	3	4	4
205	R:R:L90	R:R:T109	10.32	No	No	3	4	5
206	R:R:K107	R:R:Y92	8.36	No	No	0	3	4
207	R:R:T109	R:R:Y92	4.99	No	No	3	5	4
208	R:R:F94	R:R:K107	16.13	No	No	0	3	3
209	R:R:E294	R:R:F94	7	No	No	0	3	3
210	R:R:C95	R:R:P96	3.77	No	Yes	1	9	9
211	R:R:C95	R:R:F102	6.98	No	Yes	1	9	4
212	R:R:C134	R:R:C95	7.28	No	No	1	9	9
213	R:R:P96	R:R:Y98	12.52	Yes	Yes	1	9	4
214	R:R:P96	R:R:Y131	4.17	Yes	Yes	1	9	5
215	R:R:D97	R:R:P104	11.27	No	No	0	2	3
216	R:R:F99	R:R:Y98	7.22	Yes	Yes	1	5	4
217	R:R:F102	R:R:F99	13.93	Yes	Yes	1	4	5
218	R:R:D101	R:R:F102	5.97	No	Yes	1	4	4
219	R:R:D101	R:R:N135	10.77	No	No	1	4	3
220	R:R:C134	R:R:F102	13.97	No	Yes	1	9	4
221	R:R:F102	R:R:N135	7.25	Yes	No	1	4	3
222	R:R:D103	R:R:P104	6.44	Yes	No	0	3	3
223	R:R:D103	R:R:S105	8.83	Yes	No	0	3	1
224	R:R:D103	R:R:E106	7.8	Yes	No	8	3	4
225	R:R:D103	R:R:K141	6.91	Yes	Yes	8	3	3
226	R:R:E106	R:R:M133	4.06	No	No	0	4	5
227	R:R:E106	R:R:K141	4.05	No	Yes	8	4	3
228	R:R:V108	R:R:Y131	15.14	No	Yes	1	7	5
229	R:R:N130	R:R:T109	5.85	Yes	No	3	8	5
230	R:R:K110	R:R:W118	19.73	Yes	Yes	1	8	9
231	R:R:K110	R:R:S129	6.12	Yes	Yes	1	8	7
232	R:R:F119	R:R:Y111	5.16	No	Yes	0	4	4
233	R:R:D113	R:R:V117	4.38	No	No	0	5	5
234	R:R:K120	R:R:N125	5.6	No	No	0	1	7
235	R:R:H121	R:R:P122	10.68	Yes	No	0	4	5
236	R:R:E123	R:R:H121	9.85	No	Yes	3	4	4
237	R:R:H121	R:R:N124	5.1	Yes	No	3	4	5
238	R:R:H121	R:R:W128	23.27	Yes	Yes	3	4	5
239	R:R:N124	R:R:R126	6.03	No	No	0	5	4
240	R:R:N130	R:R:W128	11.3	Yes	Yes	3	8	5
241	R:R:S129	R:R:Y131	7.63	Yes	Yes	1	7	5
242	R:R:N130	R:R:T132	7.31	Yes	No	3	8	6
243	R:R:A136	R:R:F137	6.93	No	No	0	2	1
244	R:R:F137	R:R:K366	8.69	No	No	0	1	3
245	R:R:E140	R:R:N144	11.83	No	No	6	2	4
246	R:R:E140	R:R:K370	4.05	No	No	6	2	4
247	R:R:K370	R:R:N144	9.79	No	No	6	4	4
248	R:R:N144	R:R:Y374	5.81	No	Yes	6	4	6
249	R:R:Y146	R:R:Y150	7.94	No	No	0	2	4
250	R:R:V147	R:R:Y374	8.83	No	Yes	0	4	6
251	R:R:D373	R:R:L148	4.07	No	Yes	0	5	5
252	R:R:H377	R:R:L148	11.57	Yes	Yes	6	7	5
253	R:R:Y149	R:R:Y150	7.94	Yes	No	7	5	4
254	R:R:L202	R:R:Y149	8.21	No	Yes	0	7	5
255	R:R:L151	R:R:S378	6.01	No	No	0	5	5
256	R:R:F382	R:R:L151	3.65	Yes	No	0	7	5
257	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
258	R:R:I153	R:R:L202	5.71	No	No	0	7	7
259	R:R:F382	R:R:G155	9.03	Yes	No	0	7	8
260	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
261	R:R:H156	R:R:I198	14.58	Yes	No	0	7	7
262	R:R:H156	R:R:H381	11.94	Yes	Yes	0	7	9
263	R:R:F385	R:R:L158	15.83	Yes	No	0	5	4
264	R:R:G384	R:R:S159	3.71	No	No	0	9	9
265	R:R:I160	R:R:S195	4.64	No	No	0	5	7
266	R:R:I160	R:R:M196	5.83	No	No	0	5	4
267	R:R:F161	R:R:I165	5.02	No	No	0	4	5
268	R:R:F385	R:R:T162	7.78	Yes	No	0	5	6
269	R:R:F393	R:R:T162	5.19	No	No	0	8	6
270	R:R:F188	R:R:L163	6.09	No	No	0	8	8
271	R:R:I192	R:R:L163	4.28	No	No	0	7	8
272	R:R:C392	R:R:S166	6.89	Yes	No	14	9	9
273	R:R:F393	R:R:S166	6.61	No	No	14	8	9
274	R:R:F173	R:R:I169	3.77	Yes	No	0	7	8
275	R:R:C392	R:R:I169	4.91	Yes	No	0	9	8
276	R:R:F170	R:R:L176	3.65	Yes	Yes	0	8	9
277	R:R:F170	R:R:V181	7.87	Yes	No	0	8	9
278	R:R:F170	R:R:K185	3.72	Yes	No	0	8	6
279	R:R:F170	R:R:F188	5.36	Yes	No	0	8	8
280	R:R:C392	R:R:F170	6.98	Yes	Yes	0	9	8
281	R:R:F172	R:R:F173	9.65	No	Yes	0	2	7
282	R:R:F173	R:R:L176	3.65	Yes	Yes	0	7	9
283	R:R:F173	R:R:V402	5.24	Yes	No	0	7	5
284	R:R:F173	R:R:Q405	10.54	Yes	No	0	7	4
285	R:R:S175	R:R:T401	4.8	No	Yes	0	8	7
286	R:R:E397	R:R:L176	6.63	No	Yes	0	9	9
287	R:R:L176	R:R:V398	5.96	Yes	No	0	9	9
288	R:R:L176	R:R:T401	8.84	Yes	Yes	0	9	7
289	R:R:C178	R:R:R180	5.57	No	No	0	8	9
290	R:R:Q179	R:R:Y243	7.89	Yes	Yes	5	7	8
291	R:R:K256	R:R:Q179	4.07	No	Yes	0	5	7
292	R:R:Q179	R:R:Q257	3.84	Yes	Yes	5	7	5
293	R:R:L259	R:R:Q179	10.65	Yes	Yes	0	5	7
294	R:R:H184	R:R:R180	4.51	No	No	0	9	9
295	R:R:E397	R:R:R180	4.65	No	No	0	9	9
296	R:R:L183	R:R:Y243	7.03	No	Yes	0	8	8
297	R:R:L183	R:R:L259	5.54	No	Yes	0	8	5
298	R:R:E240	R:R:H184	11.08	No	No	0	9	9
299	R:R:H184	R:R:Y391	6.53	No	No	0	9	8
300	R:R:N186	R:R:W236	13.56	No	Yes	9	9	9
301	R:R:N186	R:R:Y263	6.98	No	No	9	9	5
302	R:R:N186	R:R:W267	7.91	No	Yes	9	9	9
303	R:R:M187	R:R:Y191	8.38	No	Yes	0	8	8
304	R:R:E240	R:R:M187	9.47	No	No	0	9	8
305	R:R:F188	R:R:V387	3.93	No	No	0	8	9
306	R:R:L189	R:R:L193	5.54	No	No	0	3	6
307	R:R:L189	R:R:W267	5.69	No	Yes	0	3	9
308	R:R:N233	R:R:T190	8.77	No	No	0	9	9
309	R:R:T190	R:R:W236	6.06	No	Yes	0	9	9
310	R:R:N233	R:R:Y191	13.96	No	Yes	2	9	8
311	R:R:M237	R:R:Y191	5.99	Yes	Yes	2	9	8
312	R:R:Q383	R:R:Y191	14.65	Yes	Yes	2	9	8
313	R:R:G384	R:R:Y191	8.69	No	Yes	0	9	8
314	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
315	R:R:L193	R:R:M229	8.48	No	No	0	6	4
316	R:R:I198	R:R:N194	8.5	No	No	0	7	8
317	R:R:H226	R:R:I197	3.98	No	No	0	6	5
318	R:R:H226	R:R:I198	3.98	No	No	0	6	7
319	R:R:H201	R:R:V205	6.92	No	No	0	6	7
320	R:R:E204	R:R:V203	4.28	No	No	0	4	3
321	R:R:P207	R:R:V206	5.3	No	No	0	3	3
322	R:R:E210	R:R:N208	11.83	No	No	0	3	3
323	R:R:L211	R:R:N208	8.24	No	No	0	1	3
324	R:R:E210	R:R:R214	11.63	No	No	0	3	4
325	R:R:L211	R:R:R214	6.07	No	No	0	1	4
326	R:R:L211	R:R:P216	6.57	No	No	0	1	4
327	R:R:C289	R:R:V212	5.12	No	No	0	9	3
328	R:R:D215	R:R:K220	11.06	No	No	0	6	7
329	R:R:D215	R:R:N288	14.81	No	No	0	6	4
330	R:R:C219	R:R:P216	3.77	No	No	0	9	4
331	R:R:C219	R:R:C289	7.28	No	No	0	9	9
332	R:R:K220	R:R:N286	6.99	No	No	4	7	7
333	R:R:K220	R:R:W290	13.92	No	Yes	4	7	9
334	R:R:H223	R:R:Q227	14.84	No	No	0	5	7
335	R:R:H223	R:R:W290	8.46	No	Yes	0	5	9
336	R:R:F224	R:R:T274	9.08	Yes	No	0	5	6
337	R:R:H277	R:R:Q227	12.36	Yes	No	4	7	7
338	R:R:I301	R:R:Q227	6.86	No	No	4	7	7
339	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
340	R:R:L271	R:R:Y228	7.03	No	No	0	4	8
341	R:R:H302	R:R:M230	6.57	Yes	No	2	6	6
342	R:R:C232	R:R:W267	3.92	No	Yes	0	8	9
343	R:R:C232	R:R:P270	5.65	No	Yes	0	8	9
344	R:R:M237	R:R:N233	4.21	Yes	No	2	9	9
345	R:R:M237	R:R:Y234	4.79	Yes	Yes	2	9	7
346	R:R:V305	R:R:Y234	11.36	No	Yes	2	7	7
347	R:R:F356	R:R:Y234	15.47	Yes	Yes	2	7	7
348	R:R:F235	R:R:L265	3.65	Yes	No	0	5	7
349	R:R:F235	R:R:F269	7.5	Yes	Yes	12	5	3
350	R:R:F235	R:R:P270	4.33	Yes	Yes	0	5	9
351	R:R:C239	R:R:W236	7.84	No	Yes	0	7	9
352	R:R:W236	R:R:Y263	3.86	Yes	No	9	9	5
353	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
354	R:R:W236	R:R:W267	17.81	Yes	Yes	9	9	9
355	R:R:M237	R:R:Q383	8.16	Yes	Yes	2	9	9
356	R:R:I242	R:R:L238	7.14	Yes	Yes	0	7	8
357	R:R:L238	R:R:L265	5.54	Yes	No	0	8	7
358	R:R:A308	R:R:L238	4.73	No	Yes	0	7	8
359	R:R:L238	R:R:N312	4.12	Yes	No	0	8	9
360	R:R:C239	R:R:Y262	5.38	No	Yes	0	7	7
361	R:R:C239	R:R:L265	4.76	No	No	0	7	7
362	R:R:E240	R:R:L351	13.25	No	No	0	9	9
363	R:R:I242	R:R:Y262	4.84	Yes	Yes	5	7	7
364	R:R:F315	R:R:I242	5.02	No	Yes	0	8	7
365	R:R:L247	R:R:Y243	9.38	No	Yes	0	8	8
366	R:R:Q257	R:R:Y243	7.89	Yes	Yes	5	5	8
367	R:R:Y243	R:R:Y262	6.95	Yes	Yes	5	8	7
368	R:R:I248	R:R:L244	4.28	No	No	0	7	9
369	R:R:I319	R:R:L244	4.28	No	No	0	9	9
370	R:R:H245	R:R:V249	16.61	No	Yes	15	8	6
371	R:R:F315	R:R:H245	23.76	No	No	0	8	8
372	R:R:H245	R:R:N318	7.65	No	No	15	8	8
373	R:R:Q257	R:R:T246	7.09	Yes	No	0	5	7
374	R:R:N318	R:R:V249	7.39	No	Yes	15	8	6
375	R:R:Q257	R:R:Y262	5.64	Yes	Yes	5	5	7
376	R:R:R258	R:R:R260	18.13	No	No	5	5	3
377	R:R:R258	R:R:W261	7	No	Yes	5	5	2
378	R:R:L259	R:R:Y263	4.69	Yes	No	0	5	5
379	R:R:R260	R:R:W261	4	No	Yes	5	3	2
380	R:R:I301	R:R:T274	4.56	No	No	0	7	6
381	R:R:H277	R:R:R281	12.41	Yes	Yes	4	7	7
382	R:R:H277	R:R:L298	3.86	Yes	No	0	7	6
383	R:R:H277	R:R:I301	7.95	Yes	No	4	7	7
384	R:R:L297	R:R:T280	8.84	No	No	0	4	4
385	R:R:I300	R:R:T280	4.56	No	No	11	8	4
386	R:R:F285	R:R:R281	5.34	Yes	Yes	4	6	7
387	R:R:D287	R:R:R281	5.96	No	Yes	4	3	7
388	R:R:R281	R:R:W290	20.99	Yes	Yes	4	7	9
389	R:R:R281	R:R:T295	6.47	Yes	Yes	4	7	4
390	R:R:V283	R:R:Y284	6.31	No	No	0	3	2
391	R:R:D287	R:R:F285	7.17	No	Yes	4	3	6
392	R:R:F285	R:R:S292	7.93	Yes	No	4	6	4
393	R:R:F285	R:R:T295	16.86	Yes	Yes	4	6	4
394	R:R:N286	R:R:W290	6.78	No	Yes	4	7	9
395	R:R:D287	R:R:S292	4.42	No	No	4	3	4
396	R:R:C289	R:R:L291	4.76	No	No	0	9	6
397	R:R:L297	R:R:T295	4.42	No	Yes	0	4	4
398	R:R:H302	R:R:L298	3.86	Yes	No	0	6	6
399	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
400	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
401	R:R:F315	R:R:V311	5.24	No	No	0	8	6
402	R:R:L352	R:R:N312	9.61	No	No	0	9	9
403	R:R:F313	R:R:L317	10.96	No	No	0	6	5
404	R:R:F313	R:R:I354	5.02	No	Yes	0	6	6
405	R:R:F313	R:R:V357	3.93	No	No	0	6	7
406	R:R:L316	R:R:L348	4.15	No	No	0	9	9
407	R:R:I354	R:R:L316	7.14	Yes	No	0	6	9
408	R:R:N318	R:R:R321	10.85	No	No	0	8	8
409	R:R:T345	R:R:V320	4.76	No	No	0	9	7
410	R:R:R328	R:R:V324	6.54	No	No	0	6	5
411	R:R:E329	R:R:T325	4.23	No	No	0	6	7
412	R:R:M327	R:R:M337	8.66	No	No	0	7	7
413	R:R:K340	R:R:M327	7.2	No	No	0	8	7
414	R:R:M337	R:R:R328	8.69	No	No	0	7	6
415	R:R:E332	R:R:H336	4.92	No	No	0	5	6
416	R:R:E332	R:R:M337	4.06	No	No	0	5	7
417	R:R:E334	R:R:Y338	4.49	No	No	0	6	7
418	R:R:H336	R:R:S335	8.37	No	No	0	6	6
419	R:R:I347	R:R:I390	4.42	No	No	0	8	8
420	R:R:I354	R:R:V349	9.22	Yes	No	0	6	8
421	R:R:L351	R:R:L352	5.54	No	No	0	9	9
422	R:R:L351	R:R:Y391	17.58	No	No	0	9	8
423	R:R:I354	R:R:L352	4.28	Yes	No	0	6	9
424	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
425	R:R:F356	R:R:Q355	10.54	Yes	Yes	2	7	8
426	R:R:L379	R:R:Q355	5.32	No	Yes	0	5	8
427	R:R:Q355	R:R:Q383	10.24	Yes	Yes	2	8	9
428	R:R:F356	R:R:I380	3.77	Yes	No	0	7	6
429	R:R:F356	R:R:Q383	4.68	Yes	Yes	2	7	9
430	R:R:F359	R:R:V358	9.18	No	No	0	6	5
431	R:R:F359	R:R:M376	6.22	No	No	0	6	7
432	R:R:G369	R:R:R362	4.5	No	Yes	0	4	4
433	R:R:R362	R:R:Y372	7.2	Yes	No	0	4	7
434	R:R:D373	R:R:R362	13.1	No	Yes	0	5	4
435	R:R:P363	R:R:Y372	5.56	No	No	0	7	7
436	R:R:L368	R:R:N365	10.98	No	No	0	3	4
437	R:R:K370	R:R:Y374	8.36	No	Yes	6	4	6
438	R:R:M376	R:R:Y372	14.37	No	No	0	7	7
439	R:R:H377	R:R:H381	9.55	Yes	Yes	0	7	9
440	R:R:H381	R:R:I380	5.3	Yes	No	0	9	6
441	R:R:F382	R:R:F386	4.29	Yes	No	0	7	5
442	R:R:F385	R:R:F386	4.29	Yes	No	0	5	5
443	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
444	R:R:I390	R:R:Y391	8.46	No	No	0	8	8
445	R:R:C392	R:R:F393	4.19	Yes	No	14	9	8
446	R:R:E397	R:R:N395	5.26	No	No	0	9	9
447	R:R:N395	R:R:V398	8.87	No	No	0	9	9
448	R:R:N396	R:R:T400	4.39	No	No	0	6	4
449	R:R:Q405	R:R:T401	4.25	No	Yes	0	4	7
450	E:E:G91	E:E:T94	3.64	No	No	0	4	7
451	L:L:T36	R:R:W79	3.64	No	Yes	0	0	6
452	R:R:L62	R:R:R74	3.64	No	No	0	3	4
453	R:R:P216	R:R:S218	3.56	No	No	0	4	3
454	E:E:P114	E:E:V118	3.53	Yes	No	0	9	7
455	E:E:V127	R:R:P304	3.53	No	Yes	0	7	9
456	R:R:P273	R:R:V272	3.53	No	No	0	6	4
457	R:R:P350	R:R:V349	3.53	No	No	0	9	8
458	L:L:L27	R:R:Y41	3.52	No	No	0	0	3
459	R:R:L90	R:R:Y111	3.52	No	Yes	0	4	4
460	R:R:L148	R:R:Y374	3.52	Yes	Yes	6	5	6
461	R:R:P139	R:R:T138	3.5	No	No	0	3	2
462	E:E:E76	E:E:R36	3.49	No	No	0	6	3
463	E:E:C82	E:E:V80	3.42	Yes	Yes	0	9	5
464	R:R:A388	R:R:S166	3.42	No	No	0	8	9
465	R:R:C219	R:R:V205	3.42	No	No	0	9	7
466	E:E:I120	E:E:P121	3.39	No	No	0	5	5
467	E:E:I125	E:E:P126	3.39	No	No	0	5	9
468	L:L:I26	R:R:P100	3.39	No	No	0	0	4
469	L:L:G33	L:L:N31	3.39	No	No	0	0	0
470	R:R:G241	R:R:N312	3.39	No	No	0	8	9
471	R:R:E114	R:R:Y111	3.37	No	Yes	0	2	4
472	R:R:A251	R:R:T254	3.36	No	No	0	6	6
473	R:R:L368	R:R:P363	3.28	No	No	0	3	7
474	E:E:N86	E:E:P87	3.26	No	No	0	9	5
475	E:E:A89	E:E:M33	3.22	No	No	0	8	8
476	R:R:V249	R:R:V250	3.21	Yes	No	0	6	5
477	L:L:L16	R:R:A145	3.15	Yes	No	0	0	4
478	E:E:V138	R:R:I242	3.07	No	Yes	0	9	7
479	R:R:I221	R:R:V217	3.07	No	No	0	4	3
480	R:R:I248	R:R:V249	3.07	No	Yes	0	7	6
481	R:R:I248	R:R:V322	3.07	No	No	0	7	8
482	E:E:K142	E:E:S141	3.06	No	No	0	8	9
483	R:R:I279	R:R:T275	3.04	No	No	0	3	3
484	E:E:F92	E:E:G41	3.01	No	No	0	8	7
485	L:L:T4	R:R:M306	3.01	Yes	No	0	0	4
486	R:R:K110	R:R:T127	3	Yes	No	0	8	4
487	R:R:K141	R:R:T138	3	Yes	No	0	3	2
488	R:R:L316	R:R:V320	2.98	No	No	0	9	7
489	E:E:L34	E:E:T31	2.95	No	No	0	5	7
490	R:R:L259	R:R:T182	2.95	Yes	No	0	5	5
491	R:R:I276	R:R:I300	2.94	No	No	0	5	8
492	L:L:A13	R:R:H201	2.93	No	No	0	0	6
493	R:R:G67	R:R:Y65	2.9	No	Yes	0	2	3
494	E:E:I125	E:E:L129	2.85	No	No	0	5	7
495	R:R:I200	R:R:L222	2.85	No	No	0	6	6
496	E:E:L37	E:E:M33	2.83	No	No	0	8	8
497	L:L:I26	L:L:N22	2.83	No	No	0	0	0
498	E:E:L59	R:R:K46	2.82	No	No	0	7	4
499	R:R:K185	R:R:L167	2.82	No	No	0	6	6
500	E:E:M75	E:E:N78	2.8	No	No	0	1	1
501	E:E:C40	E:E:F69	2.79	No	Yes	0	9	8
502	E:E:A45	E:E:F100	2.77	No	No	0	5	8
503	L:L:A5	R:R:F356	2.77	No	Yes	0	0	7
504	R:R:D50	R:R:K47	2.77	No	No	0	2	4
505	R:R:D97	R:R:K47	2.77	No	No	0	2	4
506	R:R:A278	R:R:F224	2.77	No	Yes	0	6	5
507	E:E:I96	E:E:Q99	2.74	No	No	0	6	4
508	R:R:E204	R:R:I200	2.73	No	No	0	4	6
509	E:E:C104	R:R:Y53	2.69	No	Yes	0	9	1
510	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
511	E:E:E35	E:E:L34	2.65	No	No	0	3	5
512	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
513	R:R:F314	R:R:V310	2.62	No	No	0	5	4
514	R:R:F224	R:R:T275	2.59	Yes	No	0	5	3
515	R:R:R404	R:R:T400	2.59	No	No	0	7	4
516	R:R:R404	R:R:T401	2.59	No	Yes	0	7	7
517	E:E:H97	R:R:D57	2.52	Yes	No	0	9	4
518	R:R:F225	R:R:I221	2.51	No	No	0	5	4
519	E:E:T94	R:R:Y56	2.5	No	Yes	0	7	3
520	R:R:F137	R:R:M133	2.49	No	No	0	1	5
521	E:E:V51	E:E:W56	2.45	No	No	0	6	7
522	E:E:L129	R:R:F269	2.44	No	Yes	0	7	3
523	E:E:R98	R:R:Q60	2.34	No	No	0	6	3
524	R:R:F224	R:R:F225	2.14	Yes	No	0	5	5
525	E:E:F62	E:E:Y65	2.06	Yes	No	0	8	5
526	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
527	E:E:C28	E:E:G81	1.96	No	No	0	9	4
528	E:E:P114	E:E:P115	1.95	Yes	No	0	9	8
529	E:E:P126	R:R:P273	1.95	No	No	0	9	6
530	E:E:A134	E:E:G135	1.95	No	No	0	8	7
531	L:L:P28	L:L:P29	1.95	No	No	0	0	0
532	R:R:P273	R:R:P304	1.95	No	Yes	0	6	9
533	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
534	R:R:G44	R:R:V43	1.84	No	No	0	4	2
535	R:R:G168	R:R:V171	1.84	No	No	0	1	4
536	R:R:G177	R:R:V181	1.84	No	No	0	7	9
537	E:E:G32	E:E:T31	1.82	No	No	0	3	7
538	E:E:A77	E:E:C82	1.81	No	Yes	0	7	9
539	R:R:G44	R:R:K47	1.74	No	No	0	4	4
540	E:E:G32	E:E:N29	1.7	No	No	0	3	8
541	E:E:V127	R:R:A307	1.7	No	No	0	7	3
542	E:E:V131	R:R:A307	1.7	No	No	0	6	3
543	R:R:A341	R:R:V324	1.7	No	No	0	9	5
544	R:R:C394	R:R:T389	1.69	No	No	0	5	5
545	R:R:M306	R:R:P360	1.68	No	No	0	4	5
546	R:R:E68	R:R:G69	1.64	No	No	0	1	1
547	E:E:S68	E:E:V64	1.62	No	No	0	2	4
548	E:E:A43	E:E:K42	1.61	No	No	0	2	3
549	E:E:V79	E:E:V80	1.6	No	Yes	0	1	5
550	E:E:V124	E:E:V128	1.6	No	No	0	4	4
551	R:R:V310	R:R:V357	1.6	No	No	0	4	7
552	R:R:V320	R:R:V324	1.6	No	No	0	7	5
553	R:R:A344	R:R:L323	1.58	No	No	0	9	9
554	E:E:A77	E:E:N78	1.56	No	No	0	7	1
555	E:E:I63	E:E:V64	1.54	No	No	0	6	4
556	E:E:I120	E:E:V124	1.54	No	No	0	5	4
557	R:R:I371	R:R:V375	1.54	No	No	0	5	4
558	E:E:C40	E:E:E76	1.52	No	No	0	9	6
559	R:R:K115	R:R:V117	1.52	No	No	0	5	5
560	R:R:K326	R:R:V322	1.52	No	No	0	9	8
561	R:R:M346	R:R:V342	1.52	No	No	0	8	8
562	E:E:F69	E:E:G41	1.51	Yes	No	0	8	7
563	R:R:K120	R:R:T127	1.5	No	No	0	1	4
564	R:R:G209	R:R:R213	1.5	No	No	0	3	2
565	E:E:N103	E:E:S102	1.49	No	No	0	8	7
566	E:E:L111	E:E:V109	1.49	No	No	0	4	5
567	R:R:L379	R:R:V375	1.49	No	No	0	5	4
568	E:E:D52	E:E:V51	1.46	No	No	0	6	6
569	R:R:A333	R:R:H336	1.46	No	No	0	5	6
570	E:E:D107	E:E:T105	1.45	No	No	0	5	8
571	E:E:S102	R:R:Q60	1.44	No	No	0	7	3
572	R:R:L323	R:R:M327	1.41	No	No	0	9	7
573	R:R:E332	R:R:T330	1.41	No	No	0	5	5
574	E:E:D116	E:E:I120	1.4	No	No	0	6	5
575	R:R:M367	R:R:N365	1.4	No	No	0	4	4
576	E:E:D116	E:E:L119	1.36	No	No	0	6	9
577	L:L:N31	L:L:N35	1.36	No	No	0	0	0
578	R:R:E329	R:R:K326	1.35	No	No	0	6	9
579	R:R:N396	R:R:Q399	1.32	No	No	0	6	7
580	E:E:R108	E:E:V109	1.31	No	No	0	4	5
581	R:R:F382	R:R:V154	1.31	Yes	No	0	7	6
582	R:R:R174	R:R:V171	1.31	No	No	0	7	4
583	R:R:D113	R:R:E114	1.3	No	No	0	5	2
584	R:R:A282	R:R:W290	1.3	No	Yes	0	3	9
585	R:R:E210	R:R:R213	1.16	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:F44	7.026	5	1	9
2	E:E:F62	5.322	5	1	8
3	E:E:F69	5.956	5	0	8
4	E:E:V80	4.6125	4	0	5
5	E:E:C82	4.3075	4	0	9
6	E:E:W84	9.415	4	1	9
7	E:E:H97	8.974	5	1	9
8	E:E:F101	10.24	4	1	9
9	E:E:P114	7.776	5	0	9
10	H:H:?3	10.975	4	3	0
11	L:L:T4	4.535	4	2	0
12	L:L:T6	6.4	4	2	0
13	L:L:F15	6.2375	4	8	0
14	L:L:L16	3.858	5	0	0
15	L:L:K21	10.655	4	7	0
16	L:L:Y37	8.234	5	1	0
17	L:L:?101	7.572	10	7	0
18	R:R:R45	7.155	4	1	7
19	R:R:M48	7.06	4	1	6
20	R:R:M49	6.8725	4	1	4
21	R:R:Q52	10.8075	4	1	6
22	R:R:Y53	8.298	5	1	1
23	R:R:Y56	6.17857	7	1	3
24	R:R:M59	6.935	4	1	5
25	R:R:Y65	8.17	4	13	3
26	R:R:D77	7.015	4	1	9
27	R:R:W79	9.03333	6	1	6
28	R:R:L80	9.342	5	1	5
29	R:R:W82	10.088	5	0	9
30	R:R:P96	7.9875	4	1	9
31	R:R:Y98	8.706	5	1	4
32	R:R:F99	11.36	4	1	5
33	R:R:F102	9.09833	6	1	4
34	R:R:D103	7.43	5	8	3
35	R:R:K110	10.918	5	1	8
36	R:R:Y111	4.1	4	0	4
37	R:R:W118	13.14	4	1	9
38	R:R:H121	12.29	5	3	4
39	R:R:W128	11.33	4	3	5
40	R:R:S129	6.7675	4	1	7
41	R:R:N130	12.8925	4	3	8
42	R:R:Y131	9.80667	6	1	5
43	R:R:K141	5.04	4	8	3
44	R:R:L148	5.8275	4	6	5
45	R:R:Y149	7.172	5	7	5
46	R:R:H156	10.0825	4	0	7
47	R:R:F170	5.516	5	0	8
48	R:R:F173	6.57	5	0	7
49	R:R:L176	5.746	5	0	9
50	R:R:Q179	6.6125	4	5	7
51	R:R:Y191	9.66333	6	2	8
52	R:R:F224	4.145	4	0	5
53	R:R:Y234	10.09	4	2	7
54	R:R:F235	5.815	4	12	5
55	R:R:W236	9.595	6	9	9
56	R:R:M237	5.7875	4	2	9
57	R:R:L238	5.3825	4	0	8
58	R:R:I242	5.242	5	5	7
59	R:R:Y243	7.828	5	5	8
60	R:R:V249	7.57	4	15	6
61	R:R:Q257	6.048	5	5	5
62	R:R:L259	5.9575	4	0	5
63	R:R:W261	6.674	5	5	2
64	R:R:Y262	5.70167	6	5	7
65	R:R:W267	8.8325	4	9	9
66	R:R:F269	5.9725	4	12	3
67	R:R:P270	3.47	4	0	9
68	R:R:H277	9.145	4	4	7
69	R:R:R281	10.234	5	4	7
70	R:R:F285	10.382	5	4	6
71	R:R:W290	10.29	5	4	9
72	R:R:T295	9.105	4	4	4
73	R:R:H302	7.028	5	2	6
74	R:R:P304	3.6975	4	0	9
75	R:R:I354	6.415	4	0	6
76	R:R:Q355	7.7575	4	2	8
77	R:R:F356	6.39571	7	2	7
78	R:R:R362	7.7075	4	0	4
79	R:R:Y374	6.63	4	6	6
80	R:R:H377	7.3425	4	6	7
81	R:R:H381	8.192	5	0	9
82	R:R:F382	4.57	4	0	7
83	R:R:Q383	9.4325	4	2	9
84	R:R:F385	8.92	4	0	5
85	R:R:C392	5.7425	4	14	9
86	R:R:T401	5.12	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:L37	E:E:M33	10.5175	2.83	No	No	0	8	8
2	E:E:F92	E:E:L37	11.1274	28.01	No	No	0	8	8
3	E:E:F92	E:E:G41	12.3442	3.01	No	No	0	8	7
4	E:E:F69	E:E:G41	12.9511	1.51	Yes	No	0	8	7
5	E:E:F44	E:E:F69	17.2	13.93	Yes	Yes	0	9	8
6	E:E:F44	E:E:Y66	11.4082	5.16	Yes	No	1	9	9
7	E:E:F101	E:E:F44	12.1846	4.29	Yes	Yes	1	9	9
8	E:E:M48	E:E:W56	11.0434	19.78	No	No	0	9	7
9	E:E:Y66	R:R:Y53	15.7937	9.93	No	Yes	1	9	1
10	E:E:F101	R:R:Y53	15.7318	15.47	Yes	Yes	1	9	1
11	E:E:L59	R:R:Y53	39.9065	4.69	No	Yes	0	7	1
12	E:E:L59	R:R:K46	40.0631	2.82	No	No	0	7	4
13	R:R:Q52	R:R:Y56	14.6702	4.51	Yes	Yes	1	6	3
14	E:E:W84	R:R:Q52	16.9162	6.57	Yes	Yes	1	9	6
15	E:E:W84	L:L:Y37	17.8845	5.79	Yes	Yes	1	9	0
16	L:L:?38	L:L:Y37	29.2829	5.8	No	Yes	0	0	0
17	L:L:?38	R:R:W128	43.5171	5.64	No	Yes	0	0	5
18	R:R:M59	R:R:Y56	12.2617	4.79	Yes	Yes	1	5	3
19	R:R:D50	R:R:K46	40.7506	11.06	No	No	0	2	4
20	R:R:D50	R:R:K47	40.9323	2.77	No	No	0	2	4
21	R:R:D97	R:R:K47	41.5613	2.77	No	No	0	2	4
22	R:R:D97	R:R:P104	41.7823	11.27	No	No	0	2	3
23	R:R:D103	R:R:P104	43.5186	6.44	Yes	No	0	3	3
24	L:L:F15	R:R:D103	70.8929	7.17	Yes	Yes	8	0	3
25	L:L:F15	L:L:L16	100	3.65	Yes	Yes	0	0	0
26	L:L:L12	L:L:L16	86.0084	4.15	No	Yes	0	0	0
27	L:L:L12	R:R:H377	81.2709	3.86	No	Yes	6	0	7
28	R:R:H377	R:R:H381	85.2414	9.55	Yes	Yes	0	7	9
29	R:R:H381	R:R:I380	90.0938	5.3	Yes	No	0	9	6
30	R:R:F356	R:R:I380	90.0575	3.77	Yes	No	0	7	6
31	L:L:T6	R:R:F356	16.5352	3.89	Yes	Yes	2	0	7
32	L:L:T6	R:R:H302	21.4318	8.21	Yes	Yes	2	0	6
33	R:R:H302	R:R:L298	19.3797	3.86	Yes	No	0	6	6
34	R:R:H277	R:R:L298	19.0394	3.86	Yes	No	0	7	6
35	R:R:H277	R:R:R281	14.8568	12.41	Yes	Yes	4	7	7
36	R:R:F356	R:R:Y234	18.5852	15.47	Yes	Yes	2	7	7
37	R:R:M237	R:R:Y234	23.667	4.79	Yes	Yes	2	9	7
38	R:R:M237	R:R:N233	38.6789	4.21	Yes	No	2	9	9
39	R:R:N233	R:R:T190	57.6496	8.77	No	No	0	9	9
40	R:R:T190	R:R:W236	56.9209	6.06	No	Yes	0	9	9
41	R:R:C239	R:R:W236	42.81	7.84	No	Yes	0	7	9
42	R:R:C239	R:R:L265	14.9	4.76	No	No	0	7	7
43	R:R:F235	R:R:L265	13.4038	3.65	Yes	No	0	5	7
44	R:R:F356	R:R:Q383	59.4714	4.68	Yes	Yes	2	7	9
45	R:R:M237	R:R:Q383	18.3412	8.16	Yes	Yes	2	9	9
46	R:R:Q383	R:R:Y191	41.5809	14.65	Yes	Yes	2	9	8
47	R:R:N233	R:R:Y191	19.7117	13.96	No	Yes	2	9	8
48	R:R:C239	R:R:Y262	27.6434	5.38	No	Yes	0	7	7
49	R:R:I242	R:R:Y262	14.2327	4.84	Yes	Yes	5	7	7
50	R:R:M59	R:R:R74	11.3366	9.93	Yes	No	0	5	4
51	L:L:?38	R:R:S129	15.4136	7.43	No	Yes	0	0	7
52	H:H:?3	R:R:W128	45.9963	5.11	Yes	Yes	3	0	5
53	H:H:?3	R:R:M133	53.7635	5.07	Yes	No	0	0	5
54	L:L:L16	R:R:Y149	13.0537	4.69	Yes	Yes	0	0	5
55	R:R:P207	R:R:V206	16.5769	5.3	No	No	0	3	3
56	L:L:V17	R:R:V206	15.7573	4.81	No	No	0	0	3
57	L:L:V17	R:R:L291	14.9368	5.96	No	No	0	0	6
58	L:L:Y37	R:R:W79	12.8342	13.5	Yes	Yes	1	0	6
59	R:R:D103	R:R:E106	28.2321	7.8	Yes	No	8	3	4
60	R:R:E106	R:R:M133	55.549	4.06	No	No	0	4	5
61	R:R:V387	R:R:Y191	14.161	6.31	No	Yes	0	9	8
62	R:R:F188	R:R:V387	13.8212	3.93	No	No	0	8	9
63	R:R:F170	R:R:F188	12.8018	5.36	Yes	No	0	8	8
64	R:R:M187	R:R:Y191	13.749	8.38	No	Yes	0	8	8
65	R:R:E240	R:R:M187	13.449	9.47	No	No	0	9	8
66	R:R:E240	R:R:L351	11.7417	13.25	No	No	0	9	9
67	R:R:C289	R:R:L291	14.1153	4.76	No	No	0	9	6
68	R:R:C219	R:R:C289	12.4694	7.28	No	No	0	9	9
69	R:R:L351	R:R:L352	11.7412	5.54	No	No	0	9	9
70	R:R:F315	R:R:I242	11.5212	5.02	No	Yes	0	8	7
71	R:R:I354	R:R:L352	10.0166	4.28	Yes	No	0	6	9
72	R:R:E106	R:R:K141	27.8349	4.05	No	Yes	8	4	3
73	L:L:F15	R:R:K141	28.4536	6.2	Yes	Yes	8	0	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:E74	E:E:W84	18.54	1	No	Yes	5	9	1	1
E:E:E74	L:L:Y37	4.49	1	No	Yes	5	0	1	0
E:E:P85	E:E:W84	6.76	0	No	Yes	9	9	2	1
E:E:W84	L:L:Y37	5.79	1	Yes	Yes	9	0	1	0
E:E:W84	R:R:Q52	6.57	1	Yes	Yes	9	6	1	2
H:H:?3	R:R:W128	5.11	3	Yes	Yes	0	5	2	1
H:H:?3	R:R:N130	27.11	3	Yes	Yes	0	8	2	2
L:L:K1	R:R:E294	9.45	0	No	No	0	3	0	1
L:L:C2	R:R:Y299	5.38	2	No	No	0	7	0	1
L:L:N3	R:R:W361	18.08	0	No	No	0	4	0	1
L:L:N3	R:R:R362	6.03	0	No	Yes	0	4	0	1
L:L:T4	R:R:Y299	4.99	2	Yes	No	0	7	0	1
L:L:T6	R:R:Y234	8.74	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	8.21	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	4.76	2	Yes	No	0	7	0	1
L:L:T6	R:R:F356	3.89	2	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	10.32	2	No	Yes	0	6	0	1
L:L:A8	R:R:H377	4.39	0	No	Yes	0	7	0	1
L:L:T9	R:R:H381	6.85	0	No	Yes	0	9	0	1
L:L:Q10	R:R:H226	6.18	2	No	No	0	6	0	1
L:L:Q10	R:R:M230	4.08	2	No	No	0	6	0	1
L:L:Q10	R:R:H302	6.18	2	No	Yes	0	6	0	1
L:L:R11	R:R:V293	3.92	0	No	No	0	6	0	1
L:L:L12	R:R:L148	4.15	6	No	Yes	0	5	0	1
L:L:L12	R:R:H377	3.86	6	No	Yes	0	7	0	1
L:L:N14	R:R:V293	5.91	0	No	No	0	6	0	1
L:L:F15	R:R:D103	7.17	8	Yes	Yes	0	3	0	1
L:L:F15	R:R:K141	6.2	8	Yes	Yes	0	3	0	1
L:L:L16	R:R:Y149	4.69	0	Yes	Yes	0	5	0	1
L:L:V17	R:R:V206	4.81	0	No	No	0	3	0	1
L:L:V17	R:R:L291	5.96	0	No	No	0	6	0	1
L:L:H18	R:R:P104	12.2	0	No	No	0	3	0	1
L:L:K21	R:R:Y149	8.36	7	Yes	Yes	0	5	0	1
L:L:K21	R:R:P207	13.38	7	Yes	No	0	3	0	1
L:L:N22	R:R:L142	6.87	0	No	No	0	2	0	1
L:L:F23	R:R:Y146	19.6	0	No	No	0	2	0	1
L:L:T30	R:R:F99	14.27	1	No	Yes	0	5	0	1
L:L:T30	R:R:D101	8.67	1	No	No	0	4	0	1
L:L:T30	R:R:F102	6.49	1	No	Yes	0	4	0	1
L:L:V32	R:R:N135	5.91	0	No	No	0	3	0	1
L:L:S34	R:R:H121	12.55	3	No	Yes	0	4	0	1
L:L:S34	R:R:E123	8.62	3	No	No	0	4	0	1
L:L:S34	R:R:N124	5.96	3	No	No	0	5	0	1
L:L:Y37	R:R:G78	11.59	1	Yes	No	0	5	0	1
L:L:Y37	R:R:W79	13.5	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:W128	5.64	0	No	Yes	0	5	0	1
L:L:?38	R:R:S129	7.43	0	No	Yes	0	7	0	1
L:L:?101	R:R:Y149	6.66	7	Yes	Yes	0	5	0	1
L:L:?101	R:R:Y150	4.44	7	Yes	No	0	4	0	1
L:L:?101	R:R:I153	5.4	7	Yes	No	0	7	0	1
L:L:?101	R:R:S157	11.37	7	Yes	No	0	7	0	1
L:L:?101	R:R:I160	5.4	7	Yes	No	0	5	0	1
L:L:?101	R:R:F161	5.76	7	Yes	No	0	4	0	1
L:L:?101	R:R:V164	5.64	7	Yes	No	0	4	0	1
L:L:?101	R:R:V203	7.05	7	Yes	No	0	3	0	1
L:L:?101	R:R:P207	9.32	7	Yes	No	0	3	0	1
R:R:P100	R:R:Y41	9.74	0	No	No	4	3	1	1
R:R:M48	R:R:W79	5.82	1	Yes	Yes	6	6	2	1
R:R:M48	R:R:Y98	14.37	1	Yes	Yes	6	4	2	2
R:R:D77	R:R:S129	5.89	1	Yes	Yes	9	7	2	1
R:R:D77	R:R:Y131	8.05	1	Yes	Yes	9	5	2	2
R:R:W79	R:R:Y98	6.75	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	10.02	1	Yes	Yes	5	6	1	1
R:R:W79	R:R:Y131	14.47	1	Yes	Yes	6	5	1	2
R:R:E294	R:R:F94	7	0	No	No	3	3	1	2
R:R:C95	R:R:F102	6.98	1	No	Yes	9	4	2	1
R:R:C134	R:R:C95	7.28	1	No	No	9	9	2	2
R:R:D97	R:R:P104	11.27	0	No	No	2	3	2	1
R:R:F99	R:R:Y98	7.22	1	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	13.93	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:F102	5.97	1	No	Yes	4	4	1	1
R:R:D101	R:R:N135	10.77	1	No	No	4	3	1	1
R:R:C134	R:R:F102	13.97	1	No	Yes	9	4	2	1
R:R:F102	R:R:N135	7.25	1	Yes	No	4	3	1	1
R:R:D103	R:R:P104	6.44	8	Yes	No	3	3	1	1
R:R:D103	R:R:S105	8.83	8	Yes	No	3	1	1	2
R:R:D103	R:R:E106	7.8	8	Yes	No	3	4	1	2
R:R:D103	R:R:K141	6.91	8	Yes	Yes	3	3	1	1
R:R:E106	R:R:K141	4.05	8	No	Yes	4	3	2	1
R:R:K110	R:R:S129	6.12	1	Yes	Yes	8	7	2	1
R:R:H121	R:R:P122	10.68	3	Yes	No	4	5	1	2
R:R:E123	R:R:H121	9.85	3	No	Yes	4	4	1	1
R:R:H121	R:R:N124	5.1	3	Yes	No	4	5	1	1
R:R:H121	R:R:W128	23.27	3	Yes	Yes	4	5	1	1
R:R:N124	R:R:R126	6.03	3	No	No	5	4	1	2
R:R:N130	R:R:W128	11.3	3	Yes	Yes	8	5	2	1
R:R:S129	R:R:Y131	7.63	1	Yes	Yes	7	5	1	2
R:R:Y146	R:R:Y150	7.94	0	No	No	2	4	1	1
R:R:D373	R:R:L148	4.07	0	No	Yes	5	5	2	1
R:R:H377	R:R:L148	11.57	6	Yes	Yes	7	5	1	1
R:R:Y149	R:R:Y150	7.94	7	Yes	No	5	4	1	1
R:R:L202	R:R:Y149	8.21	0	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:I153	R:R:L202	5.71	0	No	No	7	7	1	2
R:R:H156	R:R:S195	11.16	0	Yes	No	7	7	2	2
R:R:H156	R:R:I198	14.58	0	Yes	No	7	7	2	2
R:R:H156	R:R:H381	11.94	0	Yes	Yes	7	9	2	1
R:R:I160	R:R:S195	4.64	0	No	No	5	7	1	2
R:R:I160	R:R:M196	5.83	0	No	No	5	4	1	2
R:R:F161	R:R:I165	5.02	0	No	No	4	5	1	2
R:R:H226	R:R:I197	3.98	0	No	No	6	5	1	2
R:R:H226	R:R:I198	3.98	0	No	No	6	7	1	2
R:R:H201	R:R:V205	6.92	0	No	No	6	7	1	2
R:R:E204	R:R:V203	4.28	0	No	No	4	3	2	1
R:R:P207	R:R:V206	5.3	7	No	No	3	3	1	1
R:R:H302	R:R:M230	6.57	2	Yes	No	6	6	1	1
R:R:M237	R:R:Y234	4.79	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	11.36	2	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	15.47	2	Yes	Yes	7	7	1	1
R:R:M237	R:R:Q383	8.16	2	Yes	Yes	9	9	2	2
R:R:C289	R:R:L291	4.76	0	No	No	9	6	2	1
R:R:H302	R:R:L298	3.86	2	Yes	No	6	6	1	2
R:R:F356	R:R:L309	3.65	2	Yes	No	7	7	1	2
R:R:F356	R:R:Q355	10.54	2	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	10.24	2	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	3.77	2	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	2	Yes	Yes	7	9	1	2
R:R:G369	R:R:R362	4.5	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	7.2	0	Yes	No	4	7	1	2
R:R:D373	R:R:R362	13.1	0	No	Yes	5	4	2	1
R:R:H377	R:R:H381	9.55	6	Yes	Yes	7	9	1	1
R:R:H381	R:R:I380	5.3	0	Yes	No	9	6	1	2
L:L:T36	R:R:W79	3.64	0	No	Yes	0	6	0	1
L:L:L27	R:R:Y41	3.52	0	No	No	0	3	0	1
R:R:L148	R:R:Y374	3.52	6	Yes	Yes	5	6	1	2
L:L:I26	R:R:P100	3.39	0	No	No	0	4	0	1
L:L:L16	R:R:A145	3.15	0	Yes	No	0	4	0	1
L:L:T4	R:R:M306	3.01	2	Yes	No	0	4	0	1
R:R:K141	R:R:T138	3	8	Yes	No	3	2	1	2
L:L:A13	R:R:H201	2.93	0	No	No	0	6	0	1
L:L:A5	R:R:F356	2.77	0	No	Yes	0	7	0	1
R:R:M306	R:R:P360	1.68	0	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F2B_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	501
Number of Links	585
Number of Hubs	86
Number of Links mediated by Hubs	312
Number of Communities	15
Number of Nodes involved in Communities	123
Number of Links involved in Communities	171

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	302216
Length Of Smallest Path	3
Average Path Length	21.5044
Length of Longest Path	44
Minimum Path Strength	1.33
Average Path Strength	6.70793
Maximum Path Strength	23.56
Minimum Path Correlation	0.7
Average Path Correlation	0.966794
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	55.1446
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.9555
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • multicellular organismal process • ossification • amylin receptor 2 signaling pathway • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • anatomical structure development • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • protein binding • binding • signaling receptor binding • amide binding • amyloid-beta binding • peptide binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • multicellular organismal process • eating behavior • feeding behavior • cell-cell signaling • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • regulation of primary metabolic process • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of supramolecular fiber organization • metabolic process • macromolecule metabolic process • supramolecular fiber organization • regulation of metabolic process • amylin receptor 3 signaling pathway • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • molecular transducer activity • coreceptor activity • signaling receptor activity • amylin receptor activity • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • adrenomedullin receptor activity • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • regulation of biosynthetic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of protein localization to plasma membrane • regulation of localization • cellular localization • regulation of protein localization • intracellular protein localization • regulation of protein localization to membrane • positive regulation of protein localization to cell periphery • protein localization to cell periphery • protein localization to plasma membrane • positive regulation of protein localization to membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of protein localization to plasma membrane • establishment of protein localization • nitrogen compound transport • protein transport • regulation of signaling receptor activity • negative regulation of molecular function • regulation of molecular function • cross-receptor inhibition within G protein-coupled receptor heterodimer • negative regulation of signaling receptor activity • regulation of G protein-coupled receptor signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of receptor recycling • receptor recycling • receptor metabolic process • positive regulation of receptor recycling • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • heart process • circulatory system process • G protein-coupled receptor signaling pathway involved in heart process • intracellular transport • establishment of localization in cell • intracellular protein transport • adrenomedullin receptor signaling pathway • response to lipid • cellular response to oxygen-containing compound • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • cell surface • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • lytic vacuole • vacuole • lysosome • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to prostaglandin E • cellular response to ketone • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1 H:H:?2 H:H:?3
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	D6M
PDB Residues	L:L:?101
Environment Details	Open EMBL-EBI Page
Code	D6M
Name	N-hexadecanoyl-L-glutamic acid
Synonyms
Identifier
Formula	C21 H39 N O5
Molecular Weight	385.538
SMILES
PubChem	161955
Formal Charge	0
Total Atoms	66
Total Chiral Atoms	1
Total Bonds	65
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP3
UniProt	O60896
Sequence	>8F2B_nogp_Chain_E C N E T G M L E R L P L C G K A F A D M M G K V D V W K W C N L S E F I V Y Y E S F T N C T E M E A N V V G C Y W P N P L A Q G F I T G I H R Q F F S N C T V D R V H L E D P P D E V L I P L I V I P V V L T V A M A G L V V W R S K R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>8F2B_nogp_Chain_R Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published

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