psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C28	E:E:C82	7.28	No	No	0	9	9
2	E:E:N29	E:E:T31	5.85	No	No	9	8	7
3	E:E:N29	H:H:?201	28.34	No	No	9	8	0
4	E:E:E30	E:E:L88	6.63	No	No	0	7	6
5	E:E:T31	H:H:?201	5.29	No	No	9	7	0
6	E:E:L37	E:E:M33	4.24	No	Yes	0	8	8
7	E:E:C82	E:E:M33	4.86	No	Yes	0	9	8
8	E:E:M33	E:E:N86	8.41	Yes	No	0	8	9
9	E:E:L34	E:E:L88	8.3	No	No	0	5	6
10	E:E:E35	H:H:?201	7.13	No	No	0	3	0
11	E:E:E76	E:E:R36	9.3	No	No	0	6	3
12	E:E:R36	E:E:V80	6.54	No	Yes	0	3	5
13	E:E:F92	E:E:L37	10.96	No	No	0	8	8
14	E:E:C40	E:E:C72	7.28	No	No	0	9	9
15	E:E:D46	E:E:K42	4.15	No	No	0	1	3
16	E:E:F44	E:E:M48	12.44	No	No	0	9	9
17	E:E:F44	E:E:F69	15	No	Yes	0	9	8
18	E:E:M48	E:E:W56	5.82	No	Yes	0	9	7
19	E:E:F62	E:E:M48	8.71	Yes	No	0	8	9
20	E:E:V51	E:E:W56	4.9	No	Yes	0	6	7
21	E:E:E61	E:E:V51	4.28	No	No	0	6	6
22	E:E:D52	E:E:W54	6.7	No	No	0	6	3
23	E:E:D52	E:E:K55	4.15	No	No	0	6	4
24	E:E:V53	E:E:W56	6.13	No	Yes	0	4	7
25	E:E:E61	E:E:K55	4.05	No	No	0	6	4
26	E:E:F100	E:E:W56	7.02	Yes	Yes	0	8	7
27	E:E:C104	E:E:C57	7.28	No	No	0	9	9
28	E:E:F62	E:E:L59	6.09	Yes	Yes	0	8	7
29	E:E:I63	E:E:L59	7.14	No	Yes	0	6	7
30	E:E:L59	R:R:Y53	8.21	Yes	Yes	0	7	1
31	E:E:F101	E:E:F62	9.65	Yes	Yes	0	9	8
32	E:E:I63	R:R:K46	4.36	No	No	0	6	4
33	E:E:V64	E:E:Y65	7.57	No	Yes	0	4	5
34	E:E:F101	E:E:Y66	4.13	Yes	No	0	9	9
35	E:E:Y66	R:R:Q52	4.51	No	Yes	0	9	6
36	E:E:E67	H:H:?202	14.27	No	Yes	1	4	0
37	E:E:E67	R:R:R45	13.96	No	No	1	4	7
38	E:E:E67	R:R:M49	6.77	No	Yes	1	4	4
39	E:E:F69	E:E:I93	3.77	Yes	No	0	8	9
40	E:E:F69	E:E:I96	7.54	Yes	No	0	8	6
41	E:E:T70	R:R:M49	4.52	No	Yes	1	9	4
42	E:E:T70	R:R:Q52	12.76	No	Yes	1	9	6
43	E:E:M75	E:E:N71	4.21	No	No	1	1	4
44	E:E:N71	H:H:?202	24.64	No	Yes	1	4	0
45	E:E:T73	E:E:W84	7.28	No	Yes	0	9	9
46	E:E:I93	E:E:T73	4.56	No	No	0	9	9
47	E:E:E74	E:E:M75	5.41	No	No	1	5	1
48	E:E:E74	E:E:W84	9.81	No	Yes	1	5	9
49	E:E:E74	L:L:Y37	4.49	No	Yes	1	5	0
50	E:E:M75	H:H:?202	7.61	No	Yes	1	1	0
51	E:E:Y83	R:R:N124	10.47	No	No	0	6	5
52	E:E:Y83	R:R:R126	22.64	No	No	0	6	4
53	E:E:P85	E:E:W84	14.86	No	Yes	0	9	9
54	E:E:W84	L:L:Y37	4.82	Yes	Yes	1	9	0
55	E:E:A89	E:E:N86	4.69	No	No	0	8	9
56	E:E:Q90	R:R:Y56	4.51	No	Yes	1	9	3
57	E:E:Q90	R:R:M59	6.8	No	Yes	1	9	5
58	E:E:Q90	R:R:T75	7.09	No	No	1	9	5
59	E:E:F92	E:E:I96	5.02	No	No	0	8	6
60	E:E:I93	R:R:Y56	16.92	No	Yes	0	9	3
61	E:E:R98	E:E:T94	3.88	No	No	0	6	7
62	E:E:T94	R:R:Y56	4.99	No	Yes	0	7	3
63	E:E:F101	E:E:H97	15.84	Yes	Yes	1	9	9
64	E:E:H97	R:R:Y53	8.71	Yes	Yes	1	9	1
65	E:E:H97	R:R:Y56	6.53	Yes	Yes	1	9	3
66	E:E:H97	R:R:D57	5.04	Yes	Yes	1	9	4
67	E:E:H97	R:R:Q60	6.18	Yes	No	1	9	3
68	E:E:R98	R:R:Q60	7.01	No	No	0	6	3
69	E:E:F100	E:E:Q99	22.25	Yes	No	0	8	4
70	E:E:F100	E:E:F101	6.43	Yes	Yes	0	8	9
71	E:E:F101	R:R:Y53	11.35	Yes	Yes	1	9	1
72	E:E:N103	E:E:S102	5.96	No	No	0	8	7
73	E:E:V106	R:R:D57	4.38	No	Yes	0	4	4
74	E:E:E112	E:E:V109	14.26	No	No	0	4	5
75	E:E:H110	E:E:L111	5.14	No	No	0	4	4
76	E:E:L111	R:R:F285	15.83	No	Yes	0	4	6
77	E:E:D113	E:E:P114	4.83	No	Yes	0	9	9
78	E:E:D113	R:R:T295	8.67	No	Yes	0	9	4
79	E:E:D113	R:R:H296	5.04	No	No	0	9	2
80	E:E:P114	R:R:Y284	23.64	Yes	No	0	9	2
81	E:E:P114	R:R:L297	4.93	Yes	No	0	9	4
82	E:E:I123	E:E:L119	4.28	No	No	0	9	9
83	E:E:L122	R:R:T280	5.9	No	No	10	9	4
84	E:E:L122	R:R:I300	4.28	No	No	10	9	8
85	E:E:L129	R:R:F269	3.65	No	Yes	0	7	3
86	E:E:T130	R:R:F235	7.78	No	Yes	2	9	5
87	E:E:T130	R:R:F269	6.49	No	Yes	2	9	3
88	E:E:T130	R:R:P304	5.25	No	Yes	0	9	9
89	E:E:M133	R:R:L265	5.65	No	Yes	2	9	7
90	E:E:M133	R:R:F269	11.2	No	Yes	2	9	3
91	E:E:V137	R:R:I242	6.14	Yes	Yes	2	9	7
92	E:E:V137	R:R:W261	3.68	Yes	No	0	9	2
93	E:E:V137	R:R:Y262	7.57	Yes	Yes	2	9	7
94	E:E:V137	R:R:L265	5.96	Yes	Yes	2	9	7
95	E:E:V138	R:R:I242	4.61	No	Yes	0	9	7
96	E:E:R140	E:E:W139	8	No	No	0	8	9
97	E:E:R140	R:R:W261	13	No	No	0	8	2
98	E:E:S141	R:R:Q257	4.33	No	Yes	2	9	5
99	E:E:S141	R:R:Y262	5.09	No	Yes	2	9	7
100	E:E:K142	R:R:T254	10.51	No	No	0	8	6
101	H:H:?1	R:R:N125	28.34	No	No	0	0	7
102	H:H:?2	R:R:W128	6.13	Yes	Yes	3	0	5
103	H:H:?2	R:R:N130	24.64	Yes	Yes	3	0	8
104	H:H:?2	R:R:M133	6.34	Yes	No	0	0	5
105	H:H:?3	R:R:N73	25.87	No	No	0	0	4
106	L:L:K1	L:L:R11	3.71	No	No	0	0	0
107	L:L:K1	R:R:E294	12.15	No	No	0	0	3
108	L:L:C2	L:L:T4	5.07	No	No	11	0	0
109	L:L:C2	L:L:C7	7.28	No	No	0	0	0
110	L:L:C2	R:R:Y299	9.41	No	Yes	11	0	7
111	L:L:N3	R:R:W361	20.34	No	No	0	0	4
112	L:L:N3	R:R:R362	6.03	No	Yes	0	0	4
113	L:L:T4	L:L:T6	4.71	No	No	0	0	0
114	L:L:T4	R:R:Y299	3.75	No	Yes	11	0	7
115	L:L:T6	R:R:Y234	7.49	No	Yes	0	0	7
116	L:L:T6	R:R:H302	8.21	No	Yes	0	0	6
117	L:L:C7	R:R:H302	10.32	No	Yes	0	0	6
118	L:L:A8	R:R:H377	4.39	No	Yes	0	0	7
119	L:L:T9	R:R:H381	6.85	No	Yes	0	0	9
120	L:L:Q10	R:R:H226	4.95	Yes	Yes	6	0	6
121	L:L:Q10	R:R:Q227	5.12	Yes	Yes	6	0	7
122	L:L:Q10	R:R:M230	5.44	Yes	Yes	6	0	6
123	L:L:Q10	R:R:H302	6.18	Yes	Yes	6	0	6
124	L:L:L12	L:L:L16	4.15	No	Yes	0	0	0
125	L:L:L12	R:R:H377	5.14	No	Yes	0	0	7
126	L:L:H18	L:L:N14	6.38	No	No	0	0	0
127	L:L:N14	R:R:V293	4.43	No	No	0	0	6
128	L:L:F15	L:L:L16	3.65	Yes	Yes	0	0	0
129	L:L:F15	L:L:K19	11.17	Yes	Yes	0	0	0
130	L:L:F15	R:R:K141	13.65	Yes	No	0	0	3
131	L:L:F15	R:R:L142	3.65	Yes	No	0	0	2
132	L:L:L16	L:L:S20	4.5	Yes	No	7	0	0
133	L:L:F23	L:L:L16	3.65	Yes	Yes	7	0	0
134	L:L:L16	R:R:Y149	4.69	Yes	Yes	7	0	5
135	L:L:H18	L:L:V17	11.07	No	No	0	0	0
136	L:L:V17	R:R:L291	4.47	No	No	0	0	6
137	L:L:H18	L:L:K19	3.93	No	Yes	0	0	0
138	L:L:K19	R:R:D97	9.68	Yes	No	12	0	2
139	L:L:K19	R:R:P104	5.02	Yes	No	12	0	3
140	L:L:F23	L:L:S20	3.96	Yes	No	7	0	0
141	L:L:S20	R:R:Y146	5.09	No	No	7	0	2
142	L:L:L27	L:L:N21	13.73	No	No	0	0	0
143	L:L:N22	R:R:G209	5.09	No	No	0	0	3
144	L:L:F23	R:R:Y146	6.19	Yes	No	7	0	2
145	L:L:F23	R:R:Y149	11.35	Yes	Yes	7	0	5
146	L:L:F23	R:R:P207	5.78	Yes	No	0	0	3
147	L:L:G24	L:L:P25	4.06	No	No	0	0	0
148	L:L:T30	R:R:F99	16.86	No	Yes	1	0	5
149	L:L:T30	R:R:D101	8.67	No	No	1	0	4
150	L:L:T30	R:R:F102	3.89	No	Yes	1	0	4
151	L:L:N31	L:L:N35	9.54	No	No	0	0	0
152	L:L:N31	L:L:T36	5.85	No	No	0	0	0
153	L:L:V32	R:R:N135	10.35	No	Yes	0	0	3
154	L:L:S34	R:R:H121	9.76	No	Yes	3	0	4
155	L:L:S34	R:R:E123	10.06	No	No	3	0	4
156	L:L:S34	R:R:N124	8.94	No	No	0	0	5
157	L:L:?38	L:L:Y37	5.8	Yes	Yes	1	0	0
158	L:L:Y37	R:R:G78	4.35	Yes	No	0	0	5
159	L:L:Y37	R:R:W79	11.58	Yes	Yes	1	0	6
160	L:L:Y37	R:R:R126	4.12	Yes	No	0	0	4
161	L:L:?38	R:R:D77	10.08	Yes	Yes	1	0	9
162	L:L:?38	R:R:S129	7.43	Yes	Yes	1	0	7
163	L:L:?38	R:R:Y131	5.8	Yes	Yes	1	0	5
164	R:R:M48	R:R:R45	7.44	No	No	1	6	7
165	R:R:M49	R:R:R45	9.93	Yes	No	1	4	7
166	R:R:M48	R:R:W79	5.82	No	Yes	1	6	6
167	R:R:M48	R:R:Y98	13.17	No	Yes	1	6	4
168	R:R:M49	R:R:Q52	4.08	Yes	Yes	1	4	6
169	R:R:D50	R:R:K54	8.3	No	No	0	2	4
170	R:R:Q52	R:R:Y56	4.51	Yes	Yes	1	6	3
171	R:R:Q52	R:R:W76	18.62	Yes	Yes	1	6	8
172	R:R:C55	R:R:M59	4.86	No	Yes	0	9	5
173	R:R:C55	R:R:W76	3.92	No	Yes	0	9	8
174	R:R:C55	R:R:C81	7.28	No	No	0	9	9
175	R:R:M59	R:R:Y56	8.38	Yes	Yes	1	5	3
176	R:R:W76	R:R:Y56	3.86	Yes	Yes	1	8	3
177	R:R:D57	R:R:Q60	5.22	Yes	No	1	4	3
178	R:R:L62	R:R:R58	10.93	Yes	No	13	3	3
179	R:R:D83	R:R:R58	13.1	No	No	13	5	3
180	R:R:M59	R:R:R74	8.69	Yes	No	0	5	4
181	R:R:D83	R:R:L62	4.07	No	Yes	13	5	3
182	R:R:G67	R:R:Y65	5.79	No	Yes	0	2	3
183	R:R:Y65	R:R:Y71	26.81	Yes	No	14	3	3
184	R:R:D84	R:R:Y65	8.05	No	Yes	14	4	3
185	R:R:P86	R:R:Y65	6.95	No	Yes	0	2	3
186	R:R:G69	R:R:P70	4.06	No	No	0	1	1
187	R:R:A87	R:R:P70	3.74	No	No	0	4	1
188	R:R:N73	R:R:Y71	5.81	No	No	0	4	3
189	R:R:D84	R:R:Y71	6.9	No	No	14	4	3
190	R:R:C112	R:R:C72	7.28	No	No	1	9	9
191	R:R:C72	R:R:W118	19.59	No	Yes	1	9	9
192	R:R:D84	R:R:R74	15.48	No	No	0	4	4
193	R:R:K110	R:R:T75	4.5	Yes	No	1	8	5
194	R:R:T75	R:R:W118	6.06	No	Yes	1	5	9
195	R:R:G78	R:R:W76	8.44	No	Yes	0	5	8
196	R:R:D77	R:R:W82	7.82	Yes	Yes	1	9	9
197	R:R:D77	R:R:S129	7.36	Yes	Yes	1	9	7
198	R:R:D77	R:R:Y131	6.9	Yes	Yes	1	9	5
199	R:R:W79	R:R:Y98	5.79	Yes	Yes	1	6	4
200	R:R:F99	R:R:W79	9.02	Yes	Yes	1	5	6
201	R:R:W79	R:R:Y131	17.36	Yes	Yes	1	6	5
202	R:R:L80	R:R:Q93	5.32	Yes	No	0	5	6
203	R:R:L80	R:R:P96	11.49	Yes	No	0	5	9
204	R:R:L80	R:R:V108	4.47	Yes	No	1	5	7
205	R:R:L80	R:R:Y131	8.21	Yes	Yes	1	5	5
206	R:R:Q93	R:R:W82	23	No	Yes	0	6	9
207	R:R:K110	R:R:W82	23.21	Yes	Yes	1	8	9
208	R:R:S129	R:R:W82	3.71	Yes	Yes	1	7	9
209	R:R:S91	R:R:T85	6.4	No	No	0	5	7
210	R:R:P86	R:R:V89	7.07	No	No	0	2	5
211	R:R:L90	R:R:Y92	9.38	No	No	3	4	4
212	R:R:L90	R:R:T109	4.42	No	No	3	4	5
213	R:R:L90	R:R:Y111	4.69	No	No	0	4	4
214	R:R:K107	R:R:Y92	4.78	No	No	0	3	4
215	R:R:T109	R:R:Y92	6.24	No	No	3	5	4
216	R:R:C95	R:R:P96	3.77	No	No	0	9	9
217	R:R:C95	R:R:F102	5.59	No	Yes	1	9	4
218	R:R:C134	R:R:C95	7.28	No	No	1	9	9
219	R:R:P96	R:R:Y98	15.3	No	Yes	0	9	4
220	R:R:D97	R:R:P104	4.83	No	No	12	2	3
221	R:R:F99	R:R:Y98	4.13	Yes	Yes	1	5	4
222	R:R:F102	R:R:F99	10.72	Yes	Yes	1	4	5
223	R:R:D101	R:R:F102	4.78	No	Yes	1	4	4
224	R:R:D101	R:R:N135	8.08	No	Yes	1	4	3
225	R:R:C134	R:R:F102	13.97	No	Yes	1	9	4
226	R:R:F102	R:R:N135	7.25	Yes	Yes	1	4	3
227	R:R:D103	R:R:P104	4.83	No	No	0	3	3
228	R:R:D103	R:R:S105	8.83	No	No	0	3	1
229	R:R:D103	R:R:E106	6.5	No	No	0	3	4
230	R:R:E106	R:R:M133	4.06	No	No	0	4	5
231	R:R:E106	R:R:K366	5.4	No	No	0	4	3
232	R:R:V108	R:R:Y131	13.88	No	Yes	1	7	5
233	R:R:N130	R:R:T109	5.85	Yes	No	3	8	5
234	R:R:K110	R:R:W118	20.89	Yes	Yes	1	8	9
235	R:R:K110	R:R:S129	10.71	Yes	Yes	1	8	7
236	R:R:D113	R:R:Y111	5.75	No	No	0	5	4
237	R:R:C112	R:R:W118	7.84	No	Yes	1	9	9
238	R:R:D113	R:R:E114	6.5	No	No	0	5	2
239	R:R:D113	R:R:K115	4.15	No	No	0	5	5
240	R:R:H121	R:R:P122	9.15	Yes	No	0	4	5
241	R:R:E123	R:R:H121	11.08	No	Yes	3	4	4
242	R:R:H121	R:R:W128	15.87	Yes	Yes	3	4	5
243	R:R:N130	R:R:W128	7.91	Yes	Yes	3	8	5
244	R:R:S129	R:R:Y131	5.09	Yes	Yes	1	7	5
245	R:R:N130	R:R:T132	5.85	Yes	No	0	8	6
246	R:R:F137	R:R:M133	4.98	No	No	0	1	5
247	R:R:A136	R:R:F137	8.32	No	No	0	2	1
248	R:R:F137	R:R:K366	3.72	No	No	0	1	3
249	R:R:E140	R:R:N144	3.94	No	No	0	2	4
250	R:R:L142	R:R:Y146	14.07	No	No	0	2	2
251	R:R:K370	R:R:N144	9.79	No	No	15	4	4
252	R:R:N144	R:R:Y374	8.14	No	Yes	15	4	6
253	R:R:V147	R:R:Y374	8.83	No	Yes	0	4	6
254	R:R:D373	R:R:L148	4.07	No	No	0	5	5
255	R:R:H377	R:R:L148	9	Yes	No	0	7	5
256	R:R:Y149	R:R:Y150	8.94	Yes	No	0	5	4
257	R:R:I153	R:R:Y149	6.04	No	Yes	0	7	5
258	R:R:L202	R:R:Y149	8.21	No	Yes	0	7	5
259	R:R:L151	R:R:S378	6.01	No	No	0	5	5
260	R:R:F382	R:R:L151	3.65	No	No	0	7	5
261	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
262	R:R:F382	R:R:G155	9.03	No	No	0	7	8
263	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
264	R:R:H156	R:R:I198	15.91	Yes	No	0	7	7
265	R:R:H156	R:R:H381	10.75	Yes	Yes	0	7	9
266	R:R:F385	R:R:L158	15.83	Yes	No	0	5	4
267	R:R:G384	R:R:S159	3.71	No	No	0	9	9
268	R:R:F385	R:R:T162	7.78	Yes	No	0	5	6
269	R:R:F393	R:R:T162	3.89	No	No	0	8	6
270	R:R:F188	R:R:L163	4.87	Yes	No	0	8	8
271	R:R:I192	R:R:L163	4.28	No	No	0	7	8
272	R:R:F188	R:R:S166	5.28	Yes	No	0	8	9
273	R:R:C392	R:R:S166	6.89	No	No	0	9	9
274	R:R:F173	R:R:I169	7.54	Yes	No	0	7	8
275	R:R:F170	R:R:L176	4.87	Yes	Yes	0	8	9
276	R:R:F170	R:R:V181	13.11	Yes	No	0	8	9
277	R:R:F170	R:R:F188	5.36	Yes	Yes	0	8	8
278	R:R:F172	R:R:F173	13.93	No	Yes	16	2	7
279	R:R:F172	R:R:Q405	7.03	No	No	16	2	4
280	R:R:F173	R:R:L176	4.87	Yes	Yes	0	7	9
281	R:R:F173	R:R:Q405	14.05	Yes	No	16	7	4
282	R:R:L176	R:R:V398	7.45	Yes	No	0	9	9
283	R:R:L176	R:R:T401	8.84	Yes	No	0	9	7
284	R:R:C178	R:R:R180	6.96	No	No	0	8	9
285	R:R:Q179	R:R:Y243	6.76	No	Yes	0	7	8
286	R:R:K256	R:R:Q179	6.78	No	No	0	5	7
287	R:R:L259	R:R:Q179	5.32	Yes	No	0	5	7
288	R:R:R180	R:R:V181	3.92	No	No	0	9	9
289	R:R:H184	R:R:R180	6.77	No	No	0	9	9
290	R:R:L183	R:R:Y243	5.86	No	Yes	2	8	8
291	R:R:L183	R:R:L259	5.54	No	Yes	0	8	5
292	R:R:L183	R:R:Y262	4.69	No	Yes	2	8	7
293	R:R:E240	R:R:H184	9.85	No	No	0	9	9
294	R:R:N186	R:R:W236	12.43	No	Yes	8	9	9
295	R:R:N186	R:R:Y263	9.3	No	No	8	9	5
296	R:R:N186	R:R:W267	7.91	No	No	8	9	9
297	R:R:M187	R:R:Y191	8.38	No	Yes	0	8	8
298	R:R:E240	R:R:M187	10.83	No	No	0	9	8
299	R:R:F188	R:R:V387	3.93	Yes	No	0	8	9
300	R:R:L189	R:R:L193	5.54	No	No	0	3	6
301	R:R:N233	R:R:T190	8.77	Yes	No	0	9	9
302	R:R:T190	R:R:W236	6.06	No	Yes	0	9	9
303	R:R:N233	R:R:Y191	16.28	Yes	Yes	5	9	8
304	R:R:M237	R:R:Y191	5.99	Yes	Yes	5	9	8
305	R:R:Q383	R:R:Y191	13.53	Yes	Yes	5	9	8
306	R:R:G384	R:R:Y191	7.24	No	Yes	0	9	8
307	R:R:V387	R:R:Y191	3.79	No	Yes	0	9	8
308	R:R:L193	R:R:M229	9.9	No	No	0	6	4
309	R:R:I198	R:R:N194	5.66	No	No	0	7	8
310	R:R:N194	R:R:N233	5.45	No	Yes	0	8	9
311	R:R:H226	R:R:I197	3.98	Yes	No	0	6	5
312	R:R:H226	R:R:I198	3.98	Yes	No	0	6	7
313	R:R:H201	R:R:V205	9.69	No	No	0	6	7
314	R:R:E204	R:R:V203	4.28	No	No	0	4	3
315	R:R:L211	R:R:N208	6.87	No	No	0	1	3
316	R:R:G209	R:R:R213	4.5	No	No	0	3	2
317	R:R:L211	R:R:R214	4.86	No	No	0	1	4
318	R:R:L211	R:R:P216	6.57	No	No	0	1	4
319	R:R:D215	R:R:K220	11.06	No	No	0	6	7
320	R:R:D215	R:R:N288	18.85	No	No	0	6	4
321	R:R:C219	R:R:P216	5.65	No	No	0	9	4
322	R:R:C219	R:R:C289	7.28	No	No	0	9	9
323	R:R:K220	R:R:N286	5.6	No	No	4	7	7
324	R:R:K220	R:R:W290	13.92	No	Yes	4	7	9
325	R:R:H223	R:R:Q227	13.6	No	Yes	0	5	7
326	R:R:H223	R:R:W290	9.52	No	Yes	0	5	9
327	R:R:F224	R:R:T274	10.38	No	No	0	5	6
328	R:R:H226	R:R:Q227	4.95	Yes	Yes	6	6	7
329	R:R:M230	R:R:Q227	4.08	Yes	Yes	6	6	7
330	R:R:I301	R:R:Q227	8.23	No	Yes	0	7	7
331	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
332	R:R:L271	R:R:Y228	5.86	No	No	0	4	8
333	R:R:T274	R:R:Y228	4.99	No	No	0	6	8
334	R:R:M230	R:R:Y234	4.79	Yes	Yes	0	6	7
335	R:R:H302	R:R:M230	5.25	Yes	Yes	6	6	6
336	R:R:A231	R:R:P270	3.74	No	Yes	0	5	9
337	R:R:C232	R:R:W267	3.92	No	No	0	8	9
338	R:R:C232	R:R:P270	7.53	No	Yes	0	8	9
339	R:R:M237	R:R:N233	4.21	Yes	Yes	5	9	9
340	R:R:M237	R:R:Y234	4.79	Yes	Yes	0	9	7
341	R:R:V305	R:R:Y234	10.09	No	Yes	0	7	7
342	R:R:F356	R:R:Y234	12.38	Yes	Yes	0	7	7
343	R:R:F235	R:R:L265	3.65	Yes	Yes	2	5	7
344	R:R:F235	R:R:F269	6.43	Yes	Yes	2	5	3
345	R:R:F235	R:R:P270	7.22	Yes	Yes	2	5	9
346	R:R:C239	R:R:W236	7.84	No	Yes	0	7	9
347	R:R:W236	R:R:Y263	3.86	Yes	No	8	9	5
348	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
349	R:R:W236	R:R:W267	14.99	Yes	No	8	9	9
350	R:R:M237	R:R:Q383	6.8	Yes	Yes	5	9	9
351	R:R:I242	R:R:L238	7.14	Yes	No	0	7	8
352	R:R:A308	R:R:L238	4.73	No	No	0	7	8
353	R:R:L238	R:R:N312	8.24	No	No	0	8	9
354	R:R:C239	R:R:Y262	4.03	No	Yes	0	7	7
355	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
356	R:R:E240	R:R:L351	13.25	No	No	0	9	9
357	R:R:I242	R:R:Y262	4.84	Yes	Yes	2	7	7
358	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
359	R:R:L247	R:R:Y243	8.21	No	Yes	0	8	8
360	R:R:Q257	R:R:Y243	7.89	Yes	Yes	2	5	8
361	R:R:Y243	R:R:Y262	6.95	Yes	Yes	2	8	7
362	R:R:I248	R:R:L244	4.28	No	No	0	7	9
363	R:R:I319	R:R:L244	4.28	No	No	0	9	9
364	R:R:H245	R:R:V249	9.69	Yes	No	0	8	6
365	R:R:F315	R:R:H245	22.63	No	Yes	0	8	8
366	R:R:H245	R:R:N318	7.65	Yes	No	0	8	8
367	R:R:Q257	R:R:T246	7.09	Yes	No	0	5	7
368	R:R:Q257	R:R:Y262	6.76	Yes	Yes	2	5	7
369	R:R:R258	R:R:R260	10.66	No	No	0	5	3
370	R:R:L259	R:R:Y263	4.69	Yes	No	0	5	5
371	R:R:R260	R:R:W261	7	No	No	0	3	2
372	R:R:F269	R:R:L265	3.65	Yes	Yes	2	3	7
373	R:R:F269	R:R:P270	4.33	Yes	Yes	2	3	9
374	R:R:P273	R:R:V272	5.3	No	No	0	6	4
375	R:R:H277	R:R:R281	11.28	No	Yes	0	7	7
376	R:R:H277	R:R:L298	3.86	No	No	0	7	6
377	R:R:H277	R:R:I301	10.61	No	No	0	7	7
378	R:R:L297	R:R:T280	8.84	No	No	0	4	4
379	R:R:I300	R:R:T280	4.56	No	No	10	8	4
380	R:R:F285	R:R:R281	5.34	Yes	Yes	4	6	7
381	R:R:D287	R:R:R281	10.72	Yes	Yes	4	3	7
382	R:R:R281	R:R:W290	15.99	Yes	Yes	4	7	9
383	R:R:R281	R:R:T295	5.17	Yes	Yes	4	7	4
384	R:R:V283	R:R:Y284	11.36	No	No	0	3	2
385	R:R:D287	R:R:F285	7.17	Yes	Yes	4	3	6
386	R:R:F285	R:R:S292	5.28	Yes	No	4	6	4
387	R:R:F285	R:R:T295	14.27	Yes	Yes	4	6	4
388	R:R:N286	R:R:W290	5.65	No	Yes	4	7	9
389	R:R:D287	R:R:W290	4.47	Yes	Yes	4	3	9
390	R:R:D287	R:R:S292	5.89	Yes	No	4	3	4
391	R:R:C289	R:R:L291	4.76	No	No	0	9	6
392	R:R:L297	R:R:T295	4.42	No	Yes	0	4	4
393	R:R:H296	R:R:Y299	6.53	No	Yes	0	2	7
394	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
395	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
396	R:R:F315	R:R:V311	5.24	No	No	0	8	6
397	R:R:L352	R:R:N312	8.24	No	No	0	9	9
398	R:R:F313	R:R:L317	6.09	No	No	0	6	5
399	R:R:F313	R:R:V357	3.93	No	No	0	6	7
400	R:R:L316	R:R:L348	4.15	No	No	0	9	9
401	R:R:I354	R:R:L316	7.14	Yes	No	0	6	9
402	R:R:L323	R:R:M327	8.48	No	Yes	0	9	7
403	R:R:E332	R:R:M327	9.47	No	Yes	17	5	7
404	R:R:M327	R:R:M337	4.33	Yes	No	17	7	7
405	R:R:K340	R:R:M327	4.32	No	Yes	0	8	7
406	R:R:E332	R:R:H336	7.39	No	No	0	5	6
407	R:R:E332	R:R:M337	6.77	No	No	17	5	7
408	R:R:E334	R:R:Y338	11.22	No	No	0	6	7
409	R:R:H336	R:R:K340	3.93	No	No	0	6	8
410	R:R:I347	R:R:K343	5.82	No	No	0	8	8
411	R:R:M346	R:R:T345	6.02	No	No	0	8	9
412	R:R:I347	R:R:I390	5.89	No	No	0	8	8
413	R:R:P350	R:R:V349	5.3	No	No	0	9	8
414	R:R:I354	R:R:V349	7.68	Yes	No	0	6	8
415	R:R:L351	R:R:L352	4.15	No	No	0	9	9
416	R:R:L351	R:R:Y391	15.24	No	No	0	9	8
417	R:R:I354	R:R:L352	4.28	Yes	No	0	6	9
418	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
419	R:R:F356	R:R:Q355	10.54	Yes	Yes	5	7	8
420	R:R:L379	R:R:Q355	5.32	No	Yes	0	5	8
421	R:R:Q355	R:R:Q383	10.24	Yes	Yes	5	8	9
422	R:R:F356	R:R:I380	10.05	Yes	No	0	7	6
423	R:R:F356	R:R:Q383	4.68	Yes	Yes	5	7	9
424	R:R:F359	R:R:V358	5.24	No	No	0	6	5
425	R:R:F359	R:R:Y372	5.16	No	Yes	18	6	7
426	R:R:F359	R:R:M376	4.98	No	No	18	6	7
427	R:R:G369	R:R:R362	6	No	Yes	0	4	4
428	R:R:R362	R:R:Y372	7.2	Yes	Yes	0	4	7
429	R:R:D373	R:R:R362	13.1	No	Yes	0	5	4
430	R:R:P363	R:R:Y372	8.34	No	Yes	0	7	7
431	R:R:L368	R:R:N365	9.61	No	No	0	3	4
432	R:R:K370	R:R:Y374	5.97	No	Yes	15	4	6
433	R:R:M376	R:R:Y372	14.37	No	Yes	18	7	7
434	R:R:H377	R:R:H381	9.55	Yes	Yes	0	7	9
435	R:R:H381	R:R:I380	3.98	Yes	No	0	9	6
436	R:R:F382	R:R:F386	4.29	No	No	0	7	5
437	R:R:F385	R:R:F386	4.29	Yes	No	0	5	5
438	R:R:F385	R:R:T389	6.49	Yes	No	0	5	5
439	R:R:F393	R:R:T389	6.49	No	No	0	8	5
440	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
441	R:R:C392	R:R:F393	4.19	No	No	0	9	8
442	R:R:E397	R:R:N395	14.46	No	No	0	9	9
443	R:R:N395	R:R:V398	8.87	No	No	0	9	9
444	R:R:E397	R:R:N396	15.77	No	No	0	9	6
445	R:R:Q405	R:R:Q408	3.84	No	No	0	4	7
446	E:E:G91	E:E:T94	3.64	No	No	0	4	7
447	R:R:L62	R:R:R74	3.64	Yes	No	0	3	4
448	R:R:T85	R:R:W118	3.64	No	Yes	0	7	9
449	E:E:I123	R:R:Y299	3.63	No	Yes	0	9	7
450	L:L:N3	L:L:R11	3.62	No	No	0	0	0
451	E:E:M47	E:E:Y65	3.59	No	Yes	0	4	5
452	R:R:P216	R:R:S218	3.56	No	No	0	4	3
453	E:E:P114	E:E:V118	3.53	Yes	No	0	9	7
454	E:E:V127	R:R:P304	3.53	No	Yes	0	7	9
455	R:R:P207	R:R:V206	3.53	No	No	0	3	3
456	R:R:L148	R:R:Y374	3.52	No	Yes	0	5	6
457	R:R:P139	R:R:T138	3.5	No	No	0	3	2
458	R:R:A388	R:R:S166	3.42	No	No	0	8	9
459	E:E:I120	E:E:P121	3.39	No	No	0	5	5
460	E:E:I125	E:E:P126	3.39	No	No	0	5	9
461	R:R:G241	R:R:N312	3.39	No	No	0	8	9
462	L:L:L27	L:L:P28	3.28	No	No	0	0	0
463	R:R:L62	R:R:P63	3.28	Yes	No	0	3	1
464	R:R:L368	R:R:P363	3.28	No	No	0	3	7
465	E:E:E35	E:E:G32	3.27	No	No	0	3	3
466	R:R:E68	R:R:G69	3.27	No	No	0	1	1
467	R:R:F172	R:R:F409	3.22	No	No	0	2	3
468	E:E:K142	R:R:A251	3.21	No	No	0	8	6
469	L:L:V17	R:R:V212	3.21	No	No	0	0	3
470	R:R:T345	R:R:V320	3.17	No	No	0	9	7
471	R:R:T345	R:R:V342	3.17	No	No	0	9	8
472	R:R:I199	R:R:S157	3.1	No	No	0	7	7
473	R:R:I160	R:R:S195	3.1	No	No	0	5	7
474	R:R:I248	R:R:V249	3.07	No	No	0	7	6
475	R:R:I248	R:R:V322	3.07	No	No	0	7	8
476	E:E:C40	E:E:E76	3.04	No	No	0	9	6
477	R:R:K47	R:R:V43	3.04	No	No	0	4	2
478	R:R:K185	R:R:V171	3.04	No	No	0	6	4
479	R:R:K326	R:R:V322	3.04	No	No	0	9	8
480	E:E:F69	E:E:G41	3.01	Yes	No	0	8	7
481	E:E:F92	E:E:G41	3.01	No	No	0	8	7
482	R:R:K110	R:R:T127	3	Yes	No	0	8	4
483	R:R:L316	R:R:V320	2.98	No	No	0	9	7
484	E:E:N29	E:E:V80	2.96	No	Yes	0	8	5
485	R:R:L259	R:R:T182	2.95	Yes	No	0	5	5
486	R:R:I276	R:R:I300	2.94	No	No	0	5	8
487	L:L:A13	R:R:H201	2.93	No	No	0	0	6
488	R:R:I160	R:R:M196	2.92	No	No	0	5	4
489	R:R:I197	R:R:M229	2.92	No	No	0	5	4
490	R:R:I371	R:R:M367	2.92	No	No	0	5	4
491	R:R:G88	R:R:Y111	2.9	No	No	0	8	4
492	E:E:L88	E:E:M33	2.83	No	Yes	0	6	8
493	E:E:M133	R:R:L264	2.83	No	No	0	9	3
494	R:R:K185	R:R:L167	2.82	No	No	0	6	6
495	R:R:E329	R:R:T325	2.82	No	No	0	6	7
496	E:E:D116	E:E:I120	2.8	No	No	0	6	5
497	R:R:M367	R:R:N365	2.8	No	No	0	4	4
498	E:E:A45	E:E:F100	2.77	No	Yes	0	5	8
499	L:L:F15	R:R:A145	2.77	Yes	No	0	0	4
500	R:R:H201	R:R:V206	2.77	No	No	0	6	3
501	R:R:A278	R:R:F224	2.77	No	No	0	6	5
502	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
503	E:E:L59	R:R:D50	2.71	Yes	No	0	7	2
504	E:E:D116	E:E:L119	2.71	No	No	0	6	9
505	R:R:E329	R:R:K326	2.7	No	No	0	6	9
506	E:E:S68	H:H:?202	2.69	No	Yes	0	2	0
507	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
508	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
509	R:R:F173	R:R:V402	2.62	Yes	No	0	7	5
510	R:R:F314	R:R:V310	2.62	No	No	0	5	4
511	R:R:R321	R:R:V322	2.62	No	No	0	8	8
512	E:E:A77	E:E:W84	2.59	No	Yes	0	7	9
513	R:R:F224	R:R:T275	2.59	No	No	0	5	3
514	R:R:F225	R:R:I221	2.51	No	No	0	5	4
515	R:R:F313	R:R:I354	2.51	No	Yes	0	6	6
516	R:R:F170	R:R:K185	2.48	Yes	No	0	8	6
517	E:E:L136	E:E:R140	2.43	No	No	0	6	8
518	L:L:T36	R:R:W128	2.43	No	Yes	0	0	5
519	R:R:K47	R:R:Y98	2.39	No	Yes	0	4	4
520	R:R:E210	R:R:R213	2.33	No	No	0	3	2
521	H:H:?2	R:R:F119	2.19	Yes	No	0	0	4
522	E:E:F44	E:E:Y65	2.06	No	Yes	0	9	5
523	E:E:F62	E:E:Y65	2.06	Yes	Yes	0	8	5
524	R:R:G116	R:R:P70	2.03	No	No	0	9	1
525	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
526	R:R:C178	R:R:G177	1.96	No	No	0	8	7
527	E:E:P114	E:E:P115	1.95	Yes	No	0	9	8
528	E:E:P126	R:R:P304	1.95	No	Yes	0	9	9
529	L:L:P28	L:L:P29	1.95	No	No	0	0	0
530	E:E:G135	E:E:V138	1.84	No	No	0	7	9
531	R:R:G116	R:R:V117	1.84	No	No	0	9	5
532	R:R:G168	R:R:V171	1.84	No	No	0	1	4
533	L:L:G33	L:L:T36	1.82	No	No	0	0	0
534	R:R:G116	R:R:K115	1.74	No	No	0	9	5
535	E:E:C82	E:E:V80	1.71	No	Yes	0	9	5
536	E:E:V127	R:R:A307	1.7	No	No	0	7	3
537	R:R:G209	R:R:N208	1.7	No	No	0	3	3
538	R:R:A341	R:R:V324	1.7	No	No	0	9	5
539	R:R:I301	R:R:P273	1.69	No	No	0	7	6
540	R:R:C394	R:R:T389	1.69	No	No	0	5	5
541	R:R:A251	R:R:T246	1.68	No	No	0	6	7
542	R:R:M306	R:R:P360	1.68	No	No	0	4	5
543	E:E:L37	E:E:P38	1.64	No	No	0	8	5
544	L:L:L27	R:R:P100	1.64	No	No	0	0	4
545	E:E:N86	E:E:P87	1.63	No	No	0	9	5
546	L:L:P29	R:R:N135	1.63	No	Yes	0	0	3
547	E:E:A134	R:R:I242	1.62	No	Yes	0	8	7
548	L:L:A5	R:R:M376	1.61	No	No	0	0	7
549	E:E:V79	E:E:V80	1.6	No	Yes	0	1	5
550	R:R:S175	R:R:T401	1.6	No	No	0	8	7
551	R:R:V310	R:R:V357	1.6	No	No	0	4	7
552	R:R:V320	R:R:V324	1.6	No	No	0	7	5
553	R:R:A341	R:R:L323	1.58	No	No	0	9	9
554	R:R:A344	R:R:L323	1.58	No	No	0	9	9
555	E:E:C57	E:E:N58	1.57	No	No	0	9	8
556	R:R:T400	R:R:T401	1.57	No	No	0	4	7
557	E:E:A77	E:E:N78	1.56	No	No	0	7	1
558	E:E:I120	E:E:V124	1.54	No	No	0	5	4
559	E:E:I125	E:E:V124	1.54	No	No	0	5	4
560	R:R:I153	R:R:V203	1.54	No	No	0	7	3
561	R:R:I160	R:R:V164	1.54	No	No	0	5	4
562	R:R:I165	R:R:V164	1.54	No	No	0	5	4
563	R:R:I192	R:R:V164	1.54	No	No	0	7	4
564	R:R:I199	R:R:V203	1.54	No	No	0	7	3
565	R:R:I371	R:R:V375	1.54	No	No	0	5	4
566	R:R:K120	R:R:V117	1.52	No	No	0	1	5
567	R:R:M306	R:R:V357	1.52	No	No	0	4	7
568	R:R:M327	R:R:T330	1.51	Yes	No	0	7	5
569	E:E:L129	E:E:V128	1.49	No	No	0	7	4
570	R:R:L222	R:R:V205	1.49	No	No	0	6	7
571	R:R:N135	R:R:T138	1.46	Yes	No	0	3	2
572	R:R:A333	R:R:H336	1.46	No	No	0	5	6
573	R:R:I200	R:R:L222	1.43	No	No	0	6	6
574	R:R:K340	R:R:L339	1.41	No	No	0	8	6
575	R:R:K120	R:R:N125	1.4	No	No	0	1	7
576	R:R:E334	R:R:M337	1.35	No	No	0	6	7
577	E:E:C104	R:R:Y53	1.34	No	Yes	0	9	1
578	R:R:N396	R:R:Q399	1.32	No	No	0	6	7
579	R:R:D57	R:R:Q61	1.31	Yes	No	0	4	3
580	R:R:R328	R:R:V324	1.31	No	No	0	6	5
581	R:R:F161	R:R:T162	1.3	No	No	0	4	6
582	R:R:A282	R:R:W290	1.3	No	Yes	0	3	9
583	R:R:V42	R:R:Y41	1.26	No	No	0	1	3
584	R:R:F225	R:R:I197	1.26	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:M33	5.085	4	0	8
2	E:E:W56	5.9675	4	0	7
3	E:E:L59	6.0375	4	0	7
4	E:E:F62	6.6275	4	0	8
5	E:E:Y65	3.82	4	0	5
6	E:E:F69	7.33	4	0	8
7	E:E:V80	3.2025	4	0	5
8	E:E:W84	7.872	5	1	9
9	E:E:H97	8.46	5	1	9
10	E:E:F100	9.6175	4	0	8
11	E:E:F101	9.48	5	1	9
12	E:E:P114	7.776	5	0	9
13	E:E:V137	5.8375	4	2	9
14	H:H:?202	12.3025	4	1	0
15	H:H:?2	9.825	4	3	0
16	L:L:Q10	5.4225	4	6	0
17	L:L:F15	6.978	5	0	0
18	L:L:L16	4.128	5	7	0
19	L:L:K19	7.45	4	12	0
20	L:L:F23	6.186	5	7	0
21	L:L:Y37	5.86	6	1	0
22	L:L:?38	7.2775	4	1	0
23	R:R:M49	6.325	4	1	4
24	R:R:Q52	8.896	5	1	6
25	R:R:Y53	7.4025	4	1	1
26	R:R:Y56	7.1	7	1	3
27	R:R:D57	3.9875	4	1	4
28	R:R:M59	7.1825	4	1	5
29	R:R:L62	5.48	4	13	3
30	R:R:Y65	11.9	4	14	3
31	R:R:W76	8.71	4	1	8
32	R:R:D77	8.04	4	1	9
33	R:R:W79	9.914	5	1	6
34	R:R:L80	7.3725	4	1	5
35	R:R:W82	14.435	4	1	9
36	R:R:Y98	7.24167	6	1	4
37	R:R:F99	10.1825	4	1	5
38	R:R:F102	7.7	6	1	4
39	R:R:K110	12.462	5	1	8
40	R:R:W118	11.604	5	1	9
41	R:R:H121	11.465	4	3	4
42	R:R:W128	8.085	4	3	5
43	R:R:S129	6.86	5	1	7
44	R:R:N130	11.0625	4	3	8
45	R:R:Y131	9.54	6	1	5
46	R:R:N135	5.754	5	1	3
47	R:R:Y149	7.846	5	7	5
48	R:R:H156	10.1175	4	0	7
49	R:R:F170	6.455	4	0	8
50	R:R:F173	8.602	5	16	7
51	R:R:L176	6.5075	4	0	9
52	R:R:F188	4.86	4	0	8
53	R:R:Y191	9.20167	6	5	8
54	R:R:H226	4.465	4	6	6
55	R:R:Q227	7.196	5	6	7
56	R:R:M230	4.89	4	6	6
57	R:R:N233	8.6775	4	5	9
58	R:R:Y234	7.908	5	0	7
59	R:R:F235	6.27	4	2	5
60	R:R:W236	8.93667	6	8	9
61	R:R:M237	5.4475	4	5	9
62	R:R:I242	4.68667	6	2	7
63	R:R:Y243	7.134	5	2	8
64	R:R:H245	10.685	4	0	8
65	R:R:Q257	6.5175	4	2	5
66	R:R:L259	4.625	4	0	5
67	R:R:Y262	5.70429	7	2	7
68	R:R:L265	4.734	5	2	7
69	R:R:F269	5.95833	6	2	3
70	R:R:P270	4.97	5	2	9
71	R:R:R281	9.7	5	4	7
72	R:R:F285	9.578	5	4	6
73	R:R:D287	7.0625	4	4	3
74	R:R:W290	8.475	6	4	9
75	R:R:T295	8.1325	4	4	4
76	R:R:Y299	5.83	4	11	7
77	R:R:H302	7.49	4	6	6
78	R:R:P304	3.6975	4	0	9
79	R:R:M327	5.622	5	17	7
80	R:R:I354	5.4025	4	0	6
81	R:R:Q355	7.7575	4	5	8
82	R:R:F356	8.26	5	5	7
83	R:R:R362	8.0825	4	0	4
84	R:R:Y372	8.7675	4	18	7
85	R:R:Y374	6.615	4	15	6
86	R:R:H377	7.02	4	0	7
87	R:R:H381	7.69	5	0	9
88	R:R:Q383	8.8125	4	5	9
89	R:R:F385	8.5975	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C82	E:E:V80	13.2587	1.71	No	Yes	0	9	5
2	E:E:C82	E:E:M33	15.6399	4.86	No	Yes	0	9	8
3	E:E:L37	E:E:M33	23.9025	4.24	No	Yes	0	8	8
4	E:E:F92	E:E:L37	26.2428	10.96	No	No	0	8	8
5	E:E:F92	E:E:I96	13.7053	5.02	No	No	0	8	6
6	E:E:F69	E:E:I96	14.2738	7.54	Yes	No	0	8	6
7	E:E:F92	E:E:G41	13.7053	3.01	No	No	0	8	7
8	E:E:F69	E:E:G41	14.2738	3.01	Yes	No	0	8	7
9	E:E:H97	R:R:Y56	14.8595	6.53	Yes	Yes	1	9	3
10	E:E:F69	E:E:I93	33.5631	3.77	Yes	No	0	8	9
11	E:E:I93	E:E:T73	31.044	4.56	No	No	0	9	9
12	E:E:T73	E:E:W84	31.4143	7.28	No	Yes	0	9	9
13	E:E:W84	L:L:Y37	32.5582	4.82	Yes	Yes	1	9	0
14	L:L:Y37	R:R:R126	90.647	4.12	Yes	No	0	0	4
15	E:E:Y83	R:R:R126	90.8612	22.64	No	No	0	6	4
16	E:E:Y83	R:R:N124	91.0732	10.47	No	No	0	6	5
17	L:L:S34	R:R:N124	91.2828	8.94	No	No	0	0	5
18	L:L:S34	R:R:H121	91.2543	9.76	No	Yes	3	0	4
19	R:R:H121	R:R:W128	92.0986	15.87	Yes	Yes	3	4	5
20	H:H:?2	R:R:W128	88.1678	6.13	Yes	Yes	3	0	5
21	H:H:?2	R:R:M133	96.6514	6.34	Yes	No	0	0	5
22	R:R:E106	R:R:M133	96.779	4.06	No	No	0	4	5
23	R:R:D103	R:R:E106	97.8443	6.5	No	No	0	3	4
24	R:R:D103	R:R:P104	98.0859	4.83	No	No	0	3	3
25	L:L:K19	R:R:P104	97.9218	5.02	Yes	No	12	0	3
26	L:L:F15	L:L:K19	100	11.17	Yes	Yes	0	0	0
27	L:L:F15	L:L:L16	99.9556	3.65	Yes	Yes	0	0	0
28	L:L:L12	L:L:L16	99.1968	4.15	No	Yes	0	0	0
29	L:L:L12	R:R:H377	99.2195	5.14	No	Yes	0	0	7
30	R:R:H377	R:R:H381	99.0965	9.55	Yes	Yes	0	7	9
31	R:R:H156	R:R:H381	51.7472	10.75	Yes	Yes	0	7	9
32	R:R:H156	R:R:I198	53.9541	15.91	Yes	No	0	7	7
33	R:R:H226	R:R:I198	24.2124	3.98	Yes	No	0	6	7
34	R:R:H226	R:R:Q227	19.0363	4.95	Yes	Yes	6	6	7
35	R:R:H223	R:R:Q227	15.943	13.6	No	Yes	0	5	7
36	R:R:H223	R:R:W290	15.2035	9.52	No	Yes	0	5	9
37	R:R:I301	R:R:Q227	11.1087	8.23	No	Yes	0	7	7
38	R:R:H381	R:R:I380	47.7446	3.98	Yes	No	0	9	6
39	R:R:F356	R:R:I380	47.8563	10.05	Yes	No	0	7	6
40	R:R:F356	R:R:Y234	10.4866	12.38	Yes	Yes	0	7	7
41	L:L:T6	R:R:Y234	13.2906	7.49	No	Yes	0	0	7
42	L:L:T4	L:L:T6	11.9792	4.71	No	No	0	0	0
43	L:L:T4	R:R:Y299	10.7988	3.75	No	Yes	11	0	7
44	R:R:I198	R:R:N194	39.7509	5.66	No	No	0	7	8
45	R:R:N194	R:R:N233	39.5356	5.45	No	Yes	0	8	9
46	R:R:N233	R:R:T190	50.2319	8.77	Yes	No	0	9	9
47	R:R:T190	R:R:W236	49.685	6.06	No	Yes	0	9	9
48	R:R:C239	R:R:W236	38.6799	7.84	No	Yes	0	7	9
49	R:R:C239	R:R:L265	15.722	4.76	No	Yes	0	7	7
50	R:R:C239	R:R:Y262	23.612	4.03	No	Yes	0	7	7
51	R:R:I242	R:R:Y262	13.7543	4.84	Yes	Yes	2	7	7
52	R:R:N130	R:R:T109	11.8322	5.85	Yes	No	3	8	5
53	R:R:M59	R:R:R74	14.529	8.69	Yes	No	0	5	4
54	R:R:H377	R:R:L148	16.2916	9	Yes	No	0	7	5
55	R:R:D373	R:R:L148	12.5113	4.07	No	No	0	5	5
56	R:R:D373	R:R:R362	11.8732	13.1	No	Yes	0	5	4
57	R:R:M230	R:R:Y234	10.3602	4.79	Yes	Yes	0	6	7
58	L:L:H18	L:L:K19	11.2135	3.93	No	Yes	0	0	0
59	L:L:Y37	R:R:W79	18.0291	11.58	Yes	Yes	1	0	6
60	R:R:F99	R:R:W79	10.5026	9.02	Yes	Yes	1	5	6
61	R:R:W76	R:R:Y56	22.0568	3.86	Yes	Yes	1	8	3
62	R:R:G78	R:R:W76	37.495	8.44	No	Yes	0	5	8
63	R:R:F356	R:R:Q383	37.0165	4.68	Yes	Yes	5	7	9
64	R:R:Q383	R:R:Y191	36.7579	13.53	Yes	Yes	5	9	8
65	R:R:V387	R:R:Y191	28.567	3.79	No	Yes	0	9	8
66	R:R:F188	R:R:V387	27.9996	3.93	Yes	No	0	8	9
67	R:R:F188	R:R:S166	14.8879	5.28	Yes	No	0	8	9
68	R:R:C392	R:R:S166	13.58	6.89	No	No	0	9	9
69	R:R:C392	R:R:F393	12.9226	4.19	No	No	0	9	8
70	R:R:F170	R:R:F188	13.7714	5.36	Yes	Yes	0	8	8
71	R:R:F170	R:R:L176	11.2557	4.87	Yes	Yes	0	8	9
72	R:R:M187	R:R:Y191	25.3837	8.38	No	Yes	0	8	8
73	R:R:E240	R:R:M187	24.8516	10.83	No	No	0	9	8
74	R:R:M237	R:R:Y234	15.2491	4.79	Yes	Yes	0	9	7
75	R:R:E240	R:R:L351	24.2956	13.25	No	No	0	9	9
76	R:R:L351	R:R:L352	22.1035	4.15	No	No	0	9	9
77	R:R:F315	R:R:I242	10.9412	3.77	No	Yes	0	8	7
78	R:R:I354	R:R:L352	22.1445	4.28	Yes	No	0	6	9
79	R:R:I354	R:R:L316	15.6957	7.14	Yes	No	0	6	9
80	R:R:L316	R:R:V320	14.3787	2.98	No	No	0	9	7
81	R:R:V320	R:R:V324	11.7171	1.6	No	No	0	7	5
82	R:R:A341	R:R:V324	10.3727	1.7	No	No	0	9	5
83	E:E:F100	E:E:F101	10.8216	6.43	Yes	Yes	0	8	9
84	L:L:Y37	R:R:G78	37.838	4.35	Yes	No	0	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:T73	E:E:W84	7.28	0	No	Yes	9	9	2	1
E:E:E74	E:E:M75	5.41	1	No	No	5	1	1	2
E:E:E74	E:E:W84	9.81	1	No	Yes	5	9	1	1
E:E:E74	L:L:Y37	4.49	1	No	Yes	5	0	1	0
E:E:Y83	R:R:N124	10.47	0	No	No	6	5	2	1
E:E:Y83	R:R:R126	22.64	0	No	No	6	4	2	1
E:E:P85	E:E:W84	14.86	0	No	Yes	9	9	2	1
E:E:W84	L:L:Y37	4.82	1	Yes	Yes	9	0	1	0
H:H:?2	R:R:W128	6.13	3	Yes	Yes	0	5	2	1
H:H:?2	R:R:N130	24.64	3	Yes	Yes	0	8	2	2
L:L:K1	R:R:E294	12.15	0	No	No	0	3	0	1
L:L:C2	R:R:Y299	9.41	11	No	Yes	0	7	0	1
L:L:N3	R:R:W361	20.34	0	No	No	0	4	0	1
L:L:N3	R:R:R362	6.03	0	No	Yes	0	4	0	1
L:L:T4	R:R:Y299	3.75	11	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	7.49	0	No	Yes	0	7	0	1
L:L:T6	R:R:H302	8.21	0	No	Yes	0	6	0	1
L:L:C7	R:R:H302	10.32	0	No	Yes	0	6	0	1
L:L:A8	R:R:H377	4.39	0	No	Yes	0	7	0	1
L:L:T9	R:R:H381	6.85	0	No	Yes	0	9	0	1
L:L:Q10	R:R:H226	4.95	6	Yes	Yes	0	6	0	1
L:L:Q10	R:R:Q227	5.12	6	Yes	Yes	0	7	0	1
L:L:Q10	R:R:M230	5.44	6	Yes	Yes	0	6	0	1
L:L:Q10	R:R:H302	6.18	6	Yes	Yes	0	6	0	1
L:L:L12	R:R:H377	5.14	0	No	Yes	0	7	0	1
L:L:N14	R:R:V293	4.43	0	No	No	0	6	0	1
L:L:F15	R:R:K141	13.65	0	Yes	No	0	3	0	1
L:L:F15	R:R:L142	3.65	0	Yes	No	0	2	0	1
L:L:L16	R:R:Y149	4.69	7	Yes	Yes	0	5	0	1
L:L:V17	R:R:L291	4.47	0	No	No	0	6	0	1
L:L:K19	R:R:D97	9.68	12	Yes	No	0	2	0	1
L:L:K19	R:R:P104	5.02	12	Yes	No	0	3	0	1
L:L:S20	R:R:Y146	5.09	7	No	No	0	2	0	1
L:L:N22	R:R:G209	5.09	0	No	No	0	3	0	1
L:L:F23	R:R:Y146	6.19	7	Yes	No	0	2	0	1
L:L:F23	R:R:Y149	11.35	7	Yes	Yes	0	5	0	1
L:L:F23	R:R:P207	5.78	7	Yes	No	0	3	0	1
L:L:T30	R:R:F99	16.86	1	No	Yes	0	5	0	1
L:L:T30	R:R:D101	8.67	1	No	No	0	4	0	1
L:L:T30	R:R:F102	3.89	1	No	Yes	0	4	0	1
L:L:V32	R:R:N135	10.35	0	No	Yes	0	3	0	1
L:L:S34	R:R:H121	9.76	3	No	Yes	0	4	0	1
L:L:S34	R:R:E123	10.06	3	No	No	0	4	0	1
L:L:S34	R:R:N124	8.94	3	No	No	0	5	0	1
L:L:Y37	R:R:G78	4.35	1	Yes	No	0	5	0	1
L:L:Y37	R:R:W79	11.58	1	Yes	Yes	0	6	0	1
L:L:Y37	R:R:R126	4.12	1	Yes	No	0	4	0	1
L:L:?38	R:R:D77	10.08	1	Yes	Yes	0	9	0	1
L:L:?38	R:R:S129	7.43	1	Yes	Yes	0	7	0	1
L:L:?38	R:R:Y131	5.8	1	Yes	Yes	0	5	0	1
R:R:M48	R:R:W79	5.82	1	No	Yes	6	6	2	1
R:R:M48	R:R:Y98	13.17	1	No	Yes	6	4	2	2
R:R:G78	R:R:W76	8.44	0	No	Yes	5	8	1	2
R:R:D77	R:R:W82	7.82	1	Yes	Yes	9	9	1	2
R:R:D77	R:R:S129	7.36	1	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	6.9	1	Yes	Yes	9	5	1	1
R:R:W79	R:R:Y98	5.79	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	9.02	1	Yes	Yes	5	6	1	1
R:R:W79	R:R:Y131	17.36	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:V108	4.47	1	Yes	No	5	7	2	2
R:R:L80	R:R:Y131	8.21	1	Yes	Yes	5	5	2	1
R:R:K110	R:R:W82	23.21	1	Yes	Yes	8	9	2	2
R:R:S129	R:R:W82	3.71	1	Yes	Yes	7	9	1	2
R:R:C95	R:R:F102	5.59	1	No	Yes	9	4	2	1
R:R:C134	R:R:C95	7.28	1	No	No	9	9	2	2
R:R:D97	R:R:P104	4.83	12	No	No	2	3	1	1
R:R:F99	R:R:Y98	4.13	1	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	10.72	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:F102	4.78	1	No	Yes	4	4	1	1
R:R:D101	R:R:N135	8.08	1	No	Yes	4	3	1	1
R:R:C134	R:R:F102	13.97	1	No	Yes	9	4	2	1
R:R:F102	R:R:N135	7.25	1	Yes	Yes	4	3	1	1
R:R:D103	R:R:P104	4.83	0	No	No	3	3	2	1
R:R:V108	R:R:Y131	13.88	1	No	Yes	7	5	2	1
R:R:K110	R:R:S129	10.71	1	Yes	Yes	8	7	2	1
R:R:H121	R:R:P122	9.15	3	Yes	No	4	5	1	2
R:R:E123	R:R:H121	11.08	3	No	Yes	4	4	1	1
R:R:H121	R:R:W128	15.87	3	Yes	Yes	4	5	1	1
R:R:N130	R:R:W128	7.91	3	Yes	Yes	8	5	2	1
R:R:S129	R:R:Y131	5.09	1	Yes	Yes	7	5	1	1
R:R:L142	R:R:Y146	14.07	0	No	No	2	2	1	1
R:R:D373	R:R:L148	4.07	0	No	No	5	5	2	2
R:R:H377	R:R:L148	9	0	Yes	No	7	5	1	2
R:R:Y149	R:R:Y150	8.94	7	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	6.04	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	8.21	0	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	15.91	0	Yes	No	7	7	2	2
R:R:H156	R:R:H381	10.75	0	Yes	Yes	7	9	2	1
R:R:H226	R:R:I197	3.98	6	Yes	No	6	5	1	2
R:R:H226	R:R:I198	3.98	6	Yes	No	6	7	1	2
R:R:H201	R:R:V205	9.69	0	No	No	6	7	1	2
R:R:G209	R:R:R213	4.5	0	No	No	3	2	1	2
R:R:H223	R:R:Q227	13.6	0	No	Yes	5	7	2	1
R:R:H226	R:R:Q227	4.95	6	Yes	Yes	6	7	1	1
R:R:M230	R:R:Q227	4.08	6	Yes	Yes	6	7	1	1
R:R:I301	R:R:Q227	8.23	0	No	Yes	7	7	2	1
R:R:M230	R:R:Y234	4.79	6	Yes	Yes	6	7	1	1
R:R:H302	R:R:M230	5.25	6	Yes	Yes	6	6	1	1
R:R:M237	R:R:Y234	4.79	5	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	10.09	0	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	12.38	5	Yes	Yes	7	7	2	1
R:R:C289	R:R:L291	4.76	0	No	No	9	6	2	1
R:R:H296	R:R:Y299	6.53	0	No	Yes	2	7	2	1
R:R:F356	R:R:I380	10.05	5	Yes	No	7	6	2	2
R:R:F359	R:R:Y372	5.16	18	No	Yes	6	7	2	2
R:R:F359	R:R:M376	4.98	18	No	No	6	7	2	1
R:R:G369	R:R:R362	6	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	7.2	0	Yes	Yes	4	7	1	2
R:R:D373	R:R:R362	13.1	0	No	Yes	5	4	2	1
R:R:M376	R:R:Y372	14.37	18	No	Yes	7	7	1	2
R:R:H377	R:R:H381	9.55	0	Yes	Yes	7	9	1	1
R:R:H381	R:R:I380	3.98	0	Yes	No	9	6	1	2
E:E:I123	R:R:Y299	3.63	0	No	Yes	9	7	2	1
R:R:P207	R:R:V206	3.53	0	No	No	3	3	1	2
L:L:V17	R:R:V212	3.21	0	No	No	0	3	0	1
L:L:A13	R:R:H201	2.93	0	No	No	0	6	0	1
L:L:F15	R:R:A145	2.77	0	Yes	No	0	4	0	1
R:R:H201	R:R:V206	2.77	0	No	No	6	3	1	2
E:E:A77	E:E:W84	2.59	0	No	Yes	7	9	2	1
L:L:T36	R:R:W128	2.43	0	No	Yes	0	5	0	1
R:R:G209	R:R:N208	1.7	0	No	No	3	3	1	2
L:L:L27	R:R:P100	1.64	0	No	No	0	4	0	1
L:L:P29	R:R:N135	1.63	0	No	Yes	0	3	0	1
L:L:A5	R:R:M376	1.61	0	No	No	0	7	0	1
R:R:N135	R:R:T138	1.46	1	Yes	No	3	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F0K_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	494
Number of Links	584
Number of Hubs	89
Number of Links mediated by Hubs	316
Number of Communities	18
Number of Nodes involved in Communities	122
Number of Links involved in Communities	166

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	181720
Length Of Smallest Path	3
Average Path Length	21.5987
Length of Longest Path	50
Minimum Path Strength	1.455
Average Path Strength	7.21011
Maximum Path Strength	23.105
Minimum Path Correlation	0.7
Average Path Correlation	0.967673
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	57.259
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.3262
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of protein localization to plasma membrane • regulation of localization • cellular localization • regulation of protein localization • intracellular protein localization • regulation of protein localization to membrane • positive regulation of protein localization to cell periphery • protein localization to cell periphery • protein localization to plasma membrane • positive regulation of protein localization to membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of protein localization to plasma membrane • establishment of protein localization • nitrogen compound transport • protein transport • regulation of signaling receptor activity • negative regulation of molecular function • regulation of molecular function • cross-receptor inhibition within G protein-coupled receptor heterodimer • G protein-coupled receptor signaling pathway • negative regulation of signaling receptor activity • regulation of G protein-coupled receptor signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of receptor recycling • receptor recycling • receptor metabolic process • positive regulation of receptor recycling • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • heart process • multicellular organismal process • system process • circulatory system process • G protein-coupled receptor signaling pathway involved in heart process • intracellular transport • establishment of localization in cell • intracellular protein transport • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • amylin receptor signaling pathway • response to lipid • cellular response to oxygen-containing compound • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex
Gene Ontology	Cellular Component	• cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • lytic vacuole • vacuole • cytoplasm • intracellular membrane-bounded organelle • lysosome • amylin receptor complex • amylin receptor complex 3 • protein binding • binding • signaling receptor binding • amide binding • amyloid-beta binding • peptide binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • multicellular organismal process • eating behavior • feeding behavior • cell-cell signaling • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • regulation of primary metabolic process • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of supramolecular fiber organization • metabolic process • macromolecule metabolic process • supramolecular fiber organization • regulation of metabolic process • amylin receptor 3 signaling pathway • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • regulation of biosynthetic process • mRNA catabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • regulation of mRNA metabolic process • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to hormone stimulus • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?201 H:H:?202 H:H:?1 H:H:?2 H:H:?3
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP3
UniProt	O60896
Sequence	>8F0K_nogp_Chain_E G C N E T G M L E R L P L C G K A F A D M M G K V D V W K W C N L S E F I V Y Y E S F T N C T E M E A N V V G C Y W P N P L A Q G F I T G I H R Q F F S N C T V D R V H L E D P P D E V L I P L I V I P V V L T V A M A G L V V W R S K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>8F0K_nogp_Chain_R Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published

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