psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C28	E:E:C82	7.28	No	Yes	1	9	9
2	E:E:N29	E:E:T31	4.39	Yes	No	0	8	7
3	E:E:G32	E:E:N29	6.79	No	Yes	1	3	8
4	E:E:N29	H:H:?201	29.57	Yes	No	1	8	0
5	E:E:E30	E:E:T31	2.82	No	No	0	7	7
6	E:E:G32	H:H:?201	3.07	No	No	1	3	0
7	E:E:L37	E:E:M33	5.65	No	Yes	0	8	8
8	E:E:C82	E:E:M33	3.24	Yes	Yes	1	9	8
9	E:E:M33	E:E:N86	2.8	Yes	Yes	1	8	9
10	E:E:L88	E:E:M33	2.83	No	Yes	0	6	8
11	E:E:L34	E:E:L88	6.92	No	No	0	5	6
12	E:E:F92	E:E:L37	10.96	Yes	No	0	8	8
13	E:E:C40	E:E:F69	2.79	Yes	Yes	1	9	8
14	E:E:C40	E:E:C72	7.28	Yes	No	1	9	9
15	E:E:C40	E:E:T73	3.38	Yes	No	1	9	9
16	E:E:F69	E:E:G41	3.01	Yes	No	1	8	7
17	E:E:F92	E:E:G41	3.01	Yes	No	1	8	7
18	E:E:F44	E:E:M48	4.98	Yes	Yes	1	9	9
19	E:E:F44	E:E:Y66	6.19	Yes	Yes	1	9	9
20	E:E:F44	E:E:F69	12.86	Yes	Yes	1	9	8
21	E:E:F100	E:E:F44	5.36	Yes	Yes	1	8	9
22	E:E:F101	E:E:F44	4.29	Yes	Yes	1	9	9
23	E:E:A45	E:E:F100	2.77	No	Yes	0	5	8
24	E:E:M48	E:E:W56	19.78	Yes	Yes	0	9	7
25	E:E:F100	E:E:M48	6.22	Yes	Yes	1	8	9
26	E:E:F101	E:E:M48	3.73	Yes	Yes	1	9	9
27	E:E:V51	E:E:W56	3.68	No	Yes	0	6	7
28	E:E:D52	E:E:K55	4.15	No	No	0	6	4
29	E:E:V53	E:E:W56	7.36	No	Yes	0	4	7
30	E:E:K55	E:E:N58	6.99	No	No	0	4	8
31	E:E:C104	E:E:C57	7.28	No	No	0	9	9
32	E:E:F62	E:E:Y65	4.13	No	No	0	8	5
33	E:E:F101	E:E:F62	9.65	Yes	No	0	9	8
34	E:E:I63	E:E:V64	3.07	No	No	0	6	4
35	E:E:I63	R:R:K46	4.36	No	No	0	6	4
36	E:E:I63	R:R:D50	2.8	No	No	0	6	2
37	E:E:H97	E:E:Y66	6.53	Yes	Yes	1	9	9
38	E:E:F101	E:E:Y66	3.09	Yes	Yes	1	9	9
39	E:E:Y66	R:R:Y53	4.96	Yes	Yes	1	9	1
40	E:E:Y66	R:R:Y56	3.97	Yes	Yes	1	9	3
41	E:E:E67	R:R:R45	12.79	No	No	0	4	7
42	E:E:E67	R:R:M49	21.65	No	No	0	4	4
43	E:E:F69	E:E:T73	6.49	Yes	No	1	8	9
44	E:E:F69	E:E:F92	5.36	Yes	Yes	1	8	8
45	E:E:F69	E:E:I93	3.77	Yes	Yes	1	8	9
46	E:E:F69	E:E:I96	8.79	Yes	No	1	8	6
47	E:E:T70	R:R:M49	6.02	No	No	1	9	4
48	E:E:T70	R:R:Q52	12.76	No	Yes	1	9	6
49	E:E:M75	E:E:N71	8.41	No	No	9	1	4
50	E:E:N71	H:H:?202	30.8	No	No	9	4	0
51	E:E:I93	E:E:T73	9.12	Yes	No	1	9	9
52	E:E:E74	E:E:W84	23.99	No	Yes	1	5	9
53	E:E:E74	L:L:Y37	5.61	No	Yes	1	5	0
54	E:E:M75	H:H:?202	15.22	No	No	9	1	0
55	E:E:C82	E:E:N86	4.72	Yes	Yes	1	9	9
56	E:E:Y83	R:R:N124	9.3	No	No	0	6	5
57	E:E:Y83	R:R:R126	21.61	No	No	0	6	4
58	E:E:P85	E:E:W84	18.92	No	Yes	1	9	9
59	E:E:N86	E:E:W84	3.39	Yes	Yes	1	9	9
60	E:E:I93	E:E:W84	3.52	Yes	Yes	1	9	9
61	E:E:W84	L:L:Y37	3.86	Yes	Yes	1	9	0
62	E:E:W84	R:R:W76	2.81	Yes	Yes	1	9	8
63	E:E:P85	L:L:Y37	2.78	No	Yes	1	9	0
64	E:E:N86	E:E:P87	3.26	Yes	No	0	9	5
65	E:E:A89	E:E:N86	4.69	No	Yes	0	8	9
66	E:E:Q90	R:R:M59	5.44	No	Yes	0	9	5
67	E:E:Q90	R:R:T75	4.25	No	No	0	9	5
68	E:E:G91	E:E:T94	3.64	No	No	0	4	7
69	E:E:F92	E:E:I96	3.77	Yes	No	1	8	6
70	E:E:I93	R:R:Y56	12.09	Yes	Yes	1	9	3
71	E:E:G95	E:E:R98	3	No	No	0	3	6
72	E:E:F101	E:E:H97	15.84	Yes	Yes	1	9	9
73	E:E:H97	R:R:Y53	9.8	Yes	Yes	1	9	1
74	E:E:H97	R:R:Y56	7.62	Yes	Yes	1	9	3
75	E:E:H97	R:R:D57	10.08	Yes	No	1	9	4
76	E:E:Q99	E:E:R98	4.67	No	No	0	4	6
77	E:E:R98	R:R:Q60	7.01	No	No	0	6	3
78	E:E:F100	E:E:Q99	14.05	Yes	No	0	8	4
79	E:E:F100	E:E:F101	4.29	Yes	Yes	1	8	9
80	E:E:F101	R:R:Y53	16.5	Yes	Yes	1	9	1
81	E:E:C104	E:E:N103	9.45	No	No	0	9	8
82	E:E:V106	R:R:Y53	6.31	No	Yes	1	4	1
83	E:E:V106	R:R:D57	4.38	No	No	1	4	4
84	E:E:L111	E:E:V109	5.96	No	No	0	4	5
85	E:E:E112	E:E:H110	9.85	No	No	0	4	4
86	E:E:L111	R:R:F285	8.53	No	Yes	3	4	6
87	E:E:L111	R:R:D287	2.71	No	Yes	3	4	3
88	E:E:D113	E:E:P114	4.83	Yes	Yes	3	9	9
89	E:E:D113	R:R:F285	4.78	Yes	Yes	3	9	6
90	E:E:D113	R:R:T295	8.67	Yes	Yes	3	9	4
91	E:E:D113	R:R:H296	5.04	Yes	No	0	9	2
92	E:E:D113	R:R:L297	2.71	Yes	Yes	3	9	4
93	E:E:P114	E:E:V118	3.53	Yes	No	0	9	7
94	E:E:L119	E:E:P114	3.28	No	Yes	0	9	9
95	E:E:P114	R:R:Y284	22.25	Yes	No	0	9	2
96	E:E:P114	R:R:L297	6.57	Yes	Yes	3	9	4
97	E:E:E117	E:E:P115	6.29	No	No	0	4	8
98	E:E:P115	E:E:V118	3.53	No	No	0	8	7
99	E:E:D116	E:E:L119	2.71	No	No	0	6	9
100	E:E:I123	E:E:L119	4.28	No	No	0	9	9
101	E:E:I120	E:E:P121	3.39	No	No	0	5	5
102	E:E:L122	R:R:T280	4.42	No	No	3	9	4
103	E:E:L122	R:R:I300	5.71	No	Yes	3	9	8
104	E:E:I123	R:R:Y299	3.63	No	Yes	0	9	7
105	E:E:I125	E:E:P126	3.39	No	No	0	5	9
106	E:E:P126	R:R:P304	3.9	No	Yes	0	9	9
107	E:E:V127	R:R:P304	3.53	No	Yes	0	7	9
108	E:E:L129	R:R:F269	3.65	No	Yes	0	7	3
109	E:E:T130	R:R:F235	7.78	No	Yes	2	9	5
110	E:E:T130	R:R:F269	3.89	No	Yes	2	9	3
111	E:E:T130	R:R:P304	5.25	No	Yes	0	9	9
112	E:E:M133	R:R:L264	2.83	No	No	0	9	3
113	E:E:M133	R:R:L265	4.24	No	Yes	0	9	7
114	E:E:M133	R:R:F269	7.46	No	Yes	0	9	3
115	E:E:A134	R:R:L238	4.73	No	Yes	0	8	8
116	E:E:L136	R:R:W261	4.56	No	Yes	0	6	2
117	E:E:V137	R:R:I242	6.14	Yes	Yes	2	9	7
118	E:E:V137	R:R:Y262	6.31	Yes	Yes	2	9	7
119	E:E:V137	R:R:L265	2.98	Yes	Yes	0	9	7
120	E:E:V138	R:R:I242	3.07	No	Yes	0	9	7
121	E:E:V138	R:R:V250	3.21	No	No	0	9	5
122	E:E:R140	E:E:W139	5	No	No	2	8	9
123	E:E:R143	E:E:W139	3	No	No	2	8	9
124	E:E:T144	E:E:W139	12.13	No	No	0	7	9
125	E:E:R140	E:E:R143	19.19	No	No	2	8	8
126	E:E:R140	R:R:W261	10	No	Yes	2	8	2
127	E:E:S141	R:R:Q257	8.66	No	Yes	2	9	5
128	E:E:S141	R:R:Y262	5.09	No	Yes	2	9	7
129	E:E:K142	R:R:T254	19.52	No	No	0	8	6
130	L:L:K1	L:L:R11	3.71	Yes	Yes	0	0	0
131	L:L:K1	R:R:S105	3.06	Yes	No	0	0	1
132	L:L:K1	R:R:V293	4.55	Yes	No	0	0	6
133	L:L:K1	R:R:E294	12.15	Yes	No	0	0	3
134	L:L:C2	L:L:C7	7.28	Yes	No	2	0	0
135	L:L:C2	R:R:L298	3.17	Yes	No	2	0	6
136	L:L:C2	R:R:Y299	8.06	Yes	Yes	0	0	7
137	L:L:C2	R:R:H302	2.95	Yes	Yes	2	0	6
138	L:L:N3	L:L:R11	3.62	No	Yes	2	0	0
139	L:L:N3	R:R:W361	18.08	No	No	0	0	4
140	L:L:N3	R:R:R362	4.82	No	Yes	2	0	4
141	L:L:T4	L:L:T6	3.14	Yes	Yes	2	0	0
142	L:L:C7	L:L:T4	3.38	No	Yes	2	0	0
143	L:L:T4	R:R:Y299	3.75	Yes	Yes	0	0	7
144	L:L:T4	R:R:M306	3.01	Yes	No	2	0	4
145	L:L:T6	R:R:Y234	8.74	Yes	Yes	2	0	7
146	L:L:T6	R:R:H302	9.58	Yes	Yes	2	0	6
147	L:L:T6	R:R:V305	4.76	Yes	No	2	0	7
148	L:L:T6	R:R:M306	6.02	Yes	No	2	0	4
149	L:L:T6	R:R:F356	3.89	Yes	Yes	2	0	7
150	L:L:C7	R:R:H302	10.32	No	Yes	2	0	6
151	L:L:A8	L:L:R11	4.15	No	Yes	0	0	0
152	L:L:A8	R:R:H377	4.39	No	Yes	0	0	7
153	L:L:Q10	L:L:T9	2.83	Yes	No	0	0	0
154	L:L:T9	R:R:I198	3.04	No	Yes	0	0	7
155	L:L:T9	R:R:H381	2.74	No	Yes	0	0	9
156	L:L:Q10	R:R:H226	3.71	Yes	Yes	2	0	6
157	L:L:Q10	R:R:Q227	6.4	Yes	Yes	2	0	7
158	L:L:Q10	R:R:M230	2.72	Yes	Yes	2	0	6
159	L:L:Q10	R:R:H302	4.95	Yes	Yes	2	0	6
160	L:L:R11	R:R:R362	3.2	Yes	Yes	2	0	4
161	L:L:L12	R:R:L148	2.77	No	Yes	5	0	5
162	L:L:L12	R:R:H377	5.14	No	Yes	5	0	7
163	L:L:A13	R:R:H201	2.93	No	Yes	0	0	6
164	L:L:N14	R:R:V293	5.91	No	No	0	0	6
165	L:L:F15	L:L:K19	7.44	Yes	Yes	4	0	0
166	L:L:F15	R:R:D103	5.97	Yes	Yes	4	0	3
167	L:L:F15	R:R:L142	3.65	Yes	No	4	0	2
168	L:L:F15	R:R:A145	2.77	Yes	No	0	0	4
169	L:L:L16	R:R:A145	3.15	No	No	0	0	4
170	L:L:L16	R:R:Y146	8.21	No	Yes	0	0	2
171	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
172	L:L:H18	L:L:V17	9.69	Yes	No	6	0	0
173	L:L:V17	R:R:V212	4.81	No	Yes	6	0	3
174	L:L:V17	R:R:L291	2.98	No	Yes	6	0	6
175	L:L:H18	R:R:D97	5.04	Yes	No	0	0	2
176	L:L:H18	R:R:G209	3.18	Yes	No	0	0	3
177	L:L:H18	R:R:V212	4.15	Yes	Yes	6	0	3
178	L:L:H18	R:R:R213	14.67	Yes	No	0	0	2
179	L:L:K19	R:R:D103	5.53	Yes	Yes	4	0	3
180	L:L:K19	R:R:P104	3.35	Yes	No	4	0	3
181	L:L:K19	R:R:L142	2.82	Yes	No	4	0	2
182	L:L:F23	R:R:Y146	21.66	No	Yes	0	0	2
183	L:L:F23	R:R:Y150	8.25	No	No	0	0	4
184	L:L:G24	L:L:P25	4.06	No	No	0	0	0
185	L:L:I26	L:L:L27	5.71	No	No	0	0	0
186	L:L:T30	R:R:F99	5.19	No	Yes	1	0	5
187	L:L:T30	R:R:D101	4.34	No	No	0	0	4
188	L:L:T30	R:R:F102	3.89	No	Yes	1	0	4
189	L:L:N31	L:L:N35	8.17	No	No	10	0	0
190	L:L:N31	L:L:T36	4.39	No	Yes	10	0	0
191	L:L:V32	R:R:N135	7.39	No	No	0	0	3
192	L:L:S34	R:R:H121	13.95	No	No	0	0	4
193	L:L:S34	R:R:E123	7.19	No	No	0	0	4
194	L:L:N35	L:L:T36	2.92	No	Yes	10	0	0
195	L:L:?38	L:L:T36	7.3	Yes	Yes	0	0	0
196	L:L:?38	L:L:Y37	2.9	Yes	Yes	0	0	0
197	L:L:Y37	R:R:G78	7.24	Yes	No	0	0	5
198	L:L:Y37	R:R:W79	12.54	Yes	Yes	1	0	6
199	L:L:?38	R:R:W128	11.28	Yes	No	0	0	5
200	L:L:?38	R:R:Y131	5.8	Yes	Yes	0	0	5
201	R:R:R213	R:R:V43	6.54	No	No	0	2	2
202	R:R:M48	R:R:W79	5.82	No	Yes	1	6	6
203	R:R:M48	R:R:Y98	10.78	No	Yes	1	6	4
204	R:R:M49	R:R:Q52	4.08	No	Yes	1	4	6
205	R:R:Q52	R:R:Y56	7.89	Yes	Yes	1	6	3
206	R:R:Q52	R:R:W76	21.9	Yes	Yes	1	6	8
207	R:R:D57	R:R:Y53	5.75	No	Yes	1	4	1
208	R:R:K54	R:R:R58	6.19	No	Yes	0	4	3
209	R:R:C55	R:R:M59	3.24	No	Yes	0	9	5
210	R:R:C55	R:R:W76	11.75	No	Yes	0	9	8
211	R:R:C55	R:R:C81	7.28	No	No	0	9	9
212	R:R:M59	R:R:Y56	4.79	Yes	Yes	0	5	3
213	R:R:W76	R:R:Y56	4.82	Yes	Yes	1	8	3
214	R:R:Q61	R:R:R58	9.35	No	Yes	0	3	3
215	R:R:L62	R:R:R58	7.29	No	Yes	0	3	3
216	R:R:M59	R:R:R74	8.69	Yes	No	0	5	4
217	R:R:L62	R:R:P63	6.57	No	No	0	3	1
218	R:R:G67	R:R:Y65	4.35	No	Yes	0	2	3
219	R:R:Y65	R:R:Y71	23.83	Yes	No	1	3	3
220	R:R:D84	R:R:Y65	6.9	Yes	Yes	1	4	3
221	R:R:P86	R:R:Y65	5.56	No	Yes	1	2	3
222	R:R:E68	R:R:G69	3.27	No	No	0	1	1
223	R:R:G69	R:R:P70	4.06	No	No	0	1	1
224	R:R:N73	R:R:Y71	10.47	No	No	1	4	3
225	R:R:D84	R:R:Y71	3.45	Yes	No	1	4	3
226	R:R:C112	R:R:C72	7.28	No	No	1	9	9
227	R:R:C72	R:R:G116	3.92	No	No	0	9	9
228	R:R:C72	R:R:W118	15.67	No	Yes	1	9	9
229	R:R:D84	R:R:N73	4.04	Yes	No	1	4	4
230	R:R:D84	R:R:R74	15.48	Yes	No	0	4	4
231	R:R:T75	R:R:W118	4.85	No	Yes	0	5	9
232	R:R:G78	R:R:W76	7.04	No	Yes	0	5	8
233	R:R:D77	R:R:W82	8.93	No	Yes	1	9	9
234	R:R:D77	R:R:S129	7.36	No	Yes	1	9	7
235	R:R:D77	R:R:Y131	11.49	No	Yes	1	9	5
236	R:R:W79	R:R:Y98	4.82	Yes	Yes	1	6	4
237	R:R:F99	R:R:W79	6.01	Yes	Yes	1	5	6
238	R:R:F102	R:R:W79	5.01	Yes	Yes	1	4	6
239	R:R:W79	R:R:Y131	17.36	Yes	Yes	1	6	5
240	R:R:L80	R:R:W82	5.69	Yes	Yes	1	5	9
241	R:R:L80	R:R:Q93	15.97	Yes	No	1	5	6
242	R:R:L80	R:R:P96	9.85	Yes	Yes	1	5	9
243	R:R:L80	R:R:V108	4.47	Yes	Yes	1	5	7
244	R:R:L80	R:R:Y131	8.21	Yes	Yes	1	5	5
245	R:R:S91	R:R:W82	4.94	No	Yes	0	5	9
246	R:R:Q93	R:R:W82	12.05	No	Yes	1	6	9
247	R:R:V108	R:R:W82	4.9	Yes	Yes	1	7	9
248	R:R:K110	R:R:W82	17.4	Yes	Yes	1	8	9
249	R:R:S129	R:R:W82	4.94	Yes	Yes	1	7	9
250	R:R:P86	R:R:T85	3.5	No	Yes	1	2	7
251	R:R:T85	R:R:V89	3.17	Yes	No	1	7	5
252	R:R:S91	R:R:T85	3.2	No	Yes	0	5	7
253	R:R:C112	R:R:T85	5.07	No	Yes	1	9	7
254	R:R:T85	R:R:W118	6.06	Yes	Yes	1	7	9
255	R:R:P86	R:R:V89	7.07	No	No	1	2	5
256	R:R:G88	R:R:Y111	2.9	No	No	0	8	4
257	R:R:L90	R:R:Y92	4.69	No	No	11	4	4
258	R:R:L90	R:R:T109	8.84	No	No	11	4	5
259	R:R:L90	R:R:Y111	7.03	No	No	0	4	4
260	R:R:K107	R:R:Y92	8.36	No	No	0	3	4
261	R:R:T109	R:R:Y92	6.24	No	No	11	5	4
262	R:R:F94	R:R:K107	7.44	No	No	0	3	3
263	R:R:C95	R:R:P96	3.77	Yes	Yes	1	9	9
264	R:R:C95	R:R:F102	6.98	Yes	Yes	1	9	4
265	R:R:C95	R:R:V108	3.42	Yes	Yes	1	9	7
266	R:R:C134	R:R:C95	7.28	No	Yes	1	9	9
267	R:R:P96	R:R:Y98	12.52	Yes	Yes	1	9	4
268	R:R:F102	R:R:P96	5.78	Yes	Yes	1	4	9
269	R:R:P96	R:R:Y131	4.17	Yes	Yes	1	9	5
270	R:R:D97	R:R:P104	4.83	No	No	0	2	3
271	R:R:F99	R:R:Y98	9.28	Yes	Yes	1	5	4
272	R:R:F102	R:R:F99	12.86	Yes	Yes	1	4	5
273	R:R:F102	R:R:Y131	3.09	Yes	Yes	1	4	5
274	R:R:C134	R:R:F102	15.36	No	Yes	1	9	4
275	R:R:D103	R:R:P104	6.44	Yes	No	4	3	3
276	R:R:D103	R:R:S105	4.42	Yes	No	4	3	1
277	R:R:D103	R:R:E106	9.09	Yes	No	4	3	4
278	R:R:E106	R:R:S105	2.87	No	No	4	4	1
279	R:R:K107	R:R:M133	2.88	No	No	0	3	5
280	R:R:V108	R:R:Y131	13.88	Yes	Yes	1	7	5
281	R:R:N130	R:R:T109	5.85	No	No	0	8	5
282	R:R:K110	R:R:W118	22.05	Yes	Yes	1	8	9
283	R:R:K110	R:R:S129	13.77	Yes	Yes	1	8	7
284	R:R:D113	R:R:Y111	6.9	No	No	0	5	4
285	R:R:C112	R:R:W118	3.92	No	Yes	1	9	9
286	R:R:D113	R:R:F119	7.17	No	No	0	5	4
287	R:R:E114	R:R:K115	2.7	No	No	0	2	5
288	R:R:H121	R:R:P122	9.15	No	No	0	4	5
289	R:R:H121	R:R:W128	25.39	No	No	0	4	5
290	R:R:N130	R:R:W128	11.3	No	No	0	8	5
291	R:R:S129	R:R:Y131	5.09	Yes	Yes	1	7	5
292	R:R:N130	R:R:T132	8.77	No	No	0	8	6
293	R:R:A136	R:R:F137	8.32	No	No	0	2	1
294	R:R:F137	R:R:K141	4.96	No	No	0	1	3
295	R:R:P139	R:R:T138	3.5	No	No	0	3	2
296	R:R:E140	R:R:K143	8.1	No	No	0	2	1
297	R:R:E140	R:R:N144	3.94	No	No	0	2	4
298	R:R:K141	R:R:K366	5.75	No	No	0	3	3
299	R:R:L142	R:R:Y146	8.21	No	Yes	0	2	2
300	R:R:K370	R:R:N144	8.39	No	No	5	4	4
301	R:R:N144	R:R:Y374	5.81	No	Yes	5	4	6
302	R:R:V147	R:R:Y374	6.31	No	Yes	0	4	6
303	R:R:D373	R:R:L148	5.43	No	Yes	0	5	5
304	R:R:H377	R:R:L148	16.71	Yes	Yes	5	7	5
305	R:R:Y149	R:R:Y150	8.94	Yes	No	0	5	4
306	R:R:L202	R:R:Y149	7.03	No	Yes	0	7	5
307	R:R:P207	R:R:Y149	2.78	No	Yes	0	3	5
308	R:R:I153	R:R:Y150	4.84	No	No	0	7	4
309	R:R:L151	R:R:S378	4.5	No	No	0	5	5
310	R:R:F382	R:R:L151	3.65	No	No	0	7	5
311	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
312	R:R:F382	R:R:G155	9.03	No	No	0	7	8
313	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
314	R:R:H156	R:R:I198	13.26	Yes	Yes	0	7	7
315	R:R:H156	R:R:H381	11.94	Yes	Yes	0	7	9
316	R:R:F385	R:R:L158	9.74	Yes	No	0	5	4
317	R:R:G384	R:R:S159	3.71	No	No	0	9	9
318	R:R:I160	R:R:S195	4.64	No	No	0	5	7
319	R:R:F161	R:R:I165	5.02	No	No	0	4	5
320	R:R:F385	R:R:T162	7.78	Yes	No	0	5	6
321	R:R:A388	R:R:T162	3.36	No	No	0	8	6
322	R:R:F393	R:R:T162	3.89	Yes	No	0	8	6
323	R:R:F188	R:R:L163	6.09	No	Yes	0	8	8
324	R:R:L163	R:R:Y191	5.86	Yes	Yes	0	8	8
325	R:R:I192	R:R:L163	2.85	No	Yes	0	7	8
326	R:R:A388	R:R:L163	3.15	No	Yes	0	8	8
327	R:R:I192	R:R:V164	3.07	No	No	0	7	4
328	R:R:F393	R:R:I165	3.77	Yes	No	0	8	5
329	R:R:A388	R:R:S166	3.42	No	No	0	8	9
330	R:R:C392	R:R:S166	6.89	No	No	12	9	9
331	R:R:F393	R:R:S166	7.93	Yes	No	12	8	9
332	R:R:K185	R:R:L167	2.82	No	No	0	6	6
333	R:R:I169	R:R:V402	3.07	No	No	0	8	5
334	R:R:F170	R:R:V181	11.8	Yes	Yes	0	8	9
335	R:R:F170	R:R:H184	5.66	Yes	Yes	0	8	9
336	R:R:F170	R:R:F188	6.43	Yes	No	0	8	8
337	R:R:C392	R:R:F170	4.19	No	Yes	0	9	8
338	R:R:K185	R:R:V171	3.04	No	No	0	6	4
339	R:R:F172	R:R:F409	4.29	No	No	0	2	3
340	R:R:F173	R:R:S175	3.96	Yes	No	7	7	8
341	R:R:F173	R:R:L176	6.09	Yes	Yes	7	7	9
342	R:R:F173	R:R:T401	5.19	Yes	Yes	7	7	7
343	R:R:F173	R:R:Q405	11.71	Yes	Yes	7	7	4
344	R:R:S175	R:R:T401	3.2	No	Yes	7	8	7
345	R:R:Q405	R:R:S175	4.33	Yes	No	7	4	8
346	R:R:E397	R:R:L176	6.63	No	Yes	0	9	9
347	R:R:L176	R:R:V398	7.45	Yes	No	0	9	9
348	R:R:L176	R:R:T401	8.84	Yes	Yes	7	9	7
349	R:R:G177	R:R:V181	3.68	No	Yes	0	7	9
350	R:R:C178	R:R:R180	5.57	No	No	0	8	9
351	R:R:C178	R:R:V181	3.42	No	Yes	0	8	9
352	R:R:Q179	R:R:Y243	6.76	No	Yes	0	7	8
353	R:R:K256	R:R:Q179	4.07	No	No	0	5	7
354	R:R:L259	R:R:Q179	7.99	Yes	No	0	5	7
355	R:R:H184	R:R:R180	7.9	Yes	No	0	9	9
356	R:R:E397	R:R:R180	3.49	No	No	0	9	9
357	R:R:K185	R:R:V181	4.55	No	Yes	0	6	9
358	R:R:L259	R:R:T182	2.95	Yes	No	0	5	5
359	R:R:L183	R:R:W236	3.42	Yes	Yes	2	8	9
360	R:R:E240	R:R:L183	5.3	Yes	Yes	0	9	8
361	R:R:L183	R:R:Y243	5.86	Yes	Yes	2	8	8
362	R:R:L183	R:R:L259	5.54	Yes	Yes	2	8	5
363	R:R:L183	R:R:Y262	4.69	Yes	Yes	2	8	7
364	R:R:E240	R:R:H184	6.15	Yes	Yes	0	9	9
365	R:R:H184	R:R:Y391	5.44	Yes	No	0	9	8
366	R:R:N186	R:R:W236	14.69	No	Yes	2	9	9
367	R:R:N186	R:R:Y263	9.3	No	No	2	9	5
368	R:R:N186	R:R:W267	9.04	No	Yes	2	9	9
369	R:R:M187	R:R:Y191	8.38	Yes	Yes	2	8	8
370	R:R:M187	R:R:N233	2.8	Yes	Yes	2	8	9
371	R:R:M187	R:R:M237	2.89	Yes	Yes	2	8	9
372	R:R:E240	R:R:M187	10.83	Yes	Yes	0	9	8
373	R:R:F188	R:R:V387	3.93	No	No	0	8	9
374	R:R:L189	R:R:L193	4.15	No	No	0	3	6
375	R:R:L189	R:R:W267	6.83	No	Yes	0	3	9
376	R:R:N233	R:R:T190	8.77	Yes	No	2	9	9
377	R:R:T190	R:R:W236	6.06	No	Yes	2	9	9
378	R:R:T190	R:R:W267	4.85	No	Yes	2	9	9
379	R:R:N233	R:R:Y191	16.28	Yes	Yes	2	9	8
380	R:R:M237	R:R:Y191	5.99	Yes	Yes	2	9	8
381	R:R:Q383	R:R:Y191	12.4	Yes	Yes	2	9	8
382	R:R:G384	R:R:Y191	7.24	No	Yes	0	9	8
383	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
384	R:R:I192	R:R:M196	2.92	No	No	0	7	4
385	R:R:L193	R:R:M229	7.07	No	No	0	6	4
386	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
387	R:R:M230	R:R:N194	2.8	Yes	No	0	6	8
388	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
389	R:R:H226	R:R:I197	5.3	Yes	No	0	6	5
390	R:R:I197	R:R:M229	2.92	No	No	0	5	4
391	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
392	R:R:H226	R:R:I198	6.63	Yes	Yes	0	6	7
393	R:R:I200	R:R:L222	2.85	No	No	0	6	6
394	R:R:H201	R:R:V205	8.3	Yes	No	0	6	7
395	R:R:H201	R:R:V206	2.77	Yes	No	0	6	3
396	R:R:H201	R:R:L291	3.86	Yes	Yes	0	6	6
397	R:R:E204	R:R:V203	4.28	No	No	0	4	3
398	R:R:P207	R:R:V206	5.3	No	No	0	3	3
399	R:R:E210	R:R:N208	3.94	No	No	0	3	3
400	R:R:L211	R:R:N208	5.49	No	No	0	1	3
401	R:R:L211	R:R:R214	8.5	No	No	0	1	4
402	R:R:L211	R:R:P216	6.57	No	No	0	1	4
403	R:R:C289	R:R:V212	3.42	Yes	Yes	6	9	3
404	R:R:L291	R:R:V212	2.98	Yes	Yes	6	6	3
405	R:R:D215	R:R:K220	11.06	No	No	0	6	7
406	R:R:D215	R:R:N288	13.46	No	No	0	6	4
407	R:R:C289	R:R:D215	3.11	Yes	No	0	9	6
408	R:R:P216	R:R:S218	3.56	No	No	0	4	3
409	R:R:C219	R:R:P216	5.65	No	No	0	9	4
410	R:R:I221	R:R:V217	3.07	No	No	0	4	3
411	R:R:C219	R:R:C289	7.28	No	Yes	0	9	9
412	R:R:K220	R:R:N286	9.79	No	No	3	7	7
413	R:R:K220	R:R:W290	20.89	No	Yes	3	7	9
414	R:R:H223	R:R:Q227	12.36	No	Yes	0	5	7
415	R:R:H223	R:R:W290	11.64	No	Yes	0	5	9
416	R:R:F224	R:R:T274	6.49	No	No	0	5	6
417	R:R:A278	R:R:F224	2.77	No	No	0	6	5
418	R:R:H226	R:R:Q227	6.18	Yes	Yes	2	6	7
419	R:R:I301	R:R:Q227	6.86	No	Yes	0	7	7
420	R:R:C232	R:R:Y228	9.41	No	Yes	2	8	8
421	R:R:P270	R:R:Y228	2.78	Yes	Yes	2	9	8
422	R:R:L271	R:R:Y228	7.03	No	Yes	0	4	8
423	R:R:T274	R:R:Y228	4.99	No	Yes	0	6	8
424	R:R:M230	R:R:Y234	5.99	Yes	Yes	2	6	7
425	R:R:H302	R:R:M230	6.57	Yes	Yes	2	6	6
426	R:R:C232	R:R:W267	5.22	No	Yes	2	8	9
427	R:R:C232	R:R:P270	5.65	No	Yes	2	8	9
428	R:R:M237	R:R:N233	4.21	Yes	Yes	2	9	9
429	R:R:M237	R:R:Y234	4.79	Yes	Yes	2	9	7
430	R:R:V305	R:R:Y234	10.09	No	Yes	2	7	7
431	R:R:F356	R:R:Y234	13.41	Yes	Yes	2	7	7
432	R:R:F235	R:R:L265	3.65	Yes	Yes	0	5	7
433	R:R:F235	R:R:F269	5.36	Yes	Yes	2	5	3
434	R:R:A308	R:R:F235	2.77	No	Yes	0	7	5
435	R:R:C239	R:R:W236	7.84	No	Yes	0	7	9
436	R:R:W236	R:R:Y263	3.86	Yes	No	2	9	5
437	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
438	R:R:W236	R:R:W267	17.81	Yes	Yes	2	9	9
439	R:R:L309	R:R:M237	2.83	No	Yes	0	7	9
440	R:R:M237	R:R:Q383	8.16	Yes	Yes	2	9	9
441	R:R:I242	R:R:L238	5.71	Yes	Yes	0	7	8
442	R:R:L238	R:R:L265	2.77	Yes	Yes	0	8	7
443	R:R:A308	R:R:L238	4.73	No	Yes	0	7	8
444	R:R:L238	R:R:V311	2.98	Yes	No	0	8	6
445	R:R:L238	R:R:N312	4.12	Yes	No	0	8	9
446	R:R:C239	R:R:Y262	4.03	No	Yes	0	7	7
447	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
448	R:R:E240	R:R:L351	9.28	Yes	No	0	9	9
449	R:R:G241	R:R:N312	3.39	No	No	0	8	9
450	R:R:I242	R:R:Y262	4.84	Yes	Yes	2	7	7
451	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
452	R:R:L247	R:R:Y243	8.21	No	Yes	0	8	8
453	R:R:Q257	R:R:Y243	7.89	Yes	Yes	2	5	8
454	R:R:Y243	R:R:Y262	4.96	Yes	Yes	2	8	7
455	R:R:I248	R:R:L244	2.85	Yes	No	0	7	9
456	R:R:I319	R:R:L244	4.28	No	No	0	9	9
457	R:R:L244	R:R:L348	2.77	No	No	0	9	9
458	R:R:H245	R:R:V249	11.07	Yes	No	0	8	6
459	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
460	R:R:F315	R:R:H245	21.5	No	Yes	0	8	8
461	R:R:H245	R:R:N318	6.38	Yes	No	0	8	8
462	R:R:Q257	R:R:T246	8.5	Yes	No	0	5	7
463	R:R:I248	R:R:L247	2.85	Yes	No	0	7	8
464	R:R:I248	R:R:V249	3.07	Yes	No	0	7	6
465	R:R:I248	R:R:V322	3.07	Yes	No	0	7	8
466	R:R:Q257	R:R:Y262	5.64	Yes	Yes	2	5	7
467	R:R:R258	R:R:R260	13.86	No	No	2	5	3
468	R:R:R258	R:R:W261	7	No	Yes	2	5	2
469	R:R:L259	R:R:Y262	3.52	Yes	Yes	2	5	7
470	R:R:L259	R:R:Y263	5.86	Yes	No	2	5	5
471	R:R:R260	R:R:W261	5	No	Yes	2	3	2
472	R:R:F269	R:R:P270	4.33	Yes	Yes	2	3	9
473	R:R:F269	R:R:V272	3.93	Yes	No	0	3	4
474	R:R:P273	R:R:V272	3.53	No	No	0	6	4
475	R:R:I276	R:R:I300	4.42	No	Yes	0	5	8
476	R:R:H277	R:R:R281	10.16	No	Yes	0	7	7
477	R:R:H277	R:R:I301	11.93	No	No	0	7	7
478	R:R:L297	R:R:T280	8.84	Yes	No	3	4	4
479	R:R:I300	R:R:T280	3.04	Yes	No	3	8	4
480	R:R:F285	R:R:R281	5.34	Yes	Yes	3	6	7
481	R:R:D287	R:R:R281	8.34	Yes	Yes	3	3	7
482	R:R:R281	R:R:W290	15.99	Yes	Yes	3	7	9
483	R:R:R281	R:R:T295	6.47	Yes	Yes	3	7	4
484	R:R:V283	R:R:Y284	7.57	No	No	0	3	2
485	R:R:D287	R:R:F285	7.17	Yes	Yes	3	3	6
486	R:R:F285	R:R:S292	7.93	Yes	No	3	6	4
487	R:R:F285	R:R:T295	15.56	Yes	Yes	3	6	4
488	R:R:N286	R:R:W290	6.78	No	Yes	3	7	9
489	R:R:D287	R:R:W290	3.35	Yes	Yes	3	3	9
490	R:R:D287	R:R:S292	7.36	Yes	No	3	3	4
491	R:R:C289	R:R:L291	3.17	Yes	Yes	6	9	6
492	R:R:E294	R:R:S292	2.87	No	No	0	3	4
493	R:R:L298	R:R:V293	2.98	No	No	0	6	6
494	R:R:L297	R:R:T295	5.9	Yes	Yes	3	4	4
495	R:R:H296	R:R:Y299	3.27	No	Yes	0	2	7
496	R:R:I300	R:R:L297	2.85	Yes	Yes	3	8	4
497	R:R:H302	R:R:L298	3.86	Yes	No	2	6	6
498	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
499	R:R:F356	R:R:L309	4.87	Yes	No	0	7	7
500	R:R:F314	R:R:V310	3.93	No	No	0	5	4
501	R:R:F315	R:R:V311	5.24	No	No	0	8	6
502	R:R:L352	R:R:N312	10.98	No	No	0	9	9
503	R:R:F313	R:R:L317	9.74	Yes	No	0	6	5
504	R:R:F313	R:R:I354	5.02	Yes	Yes	0	6	6
505	R:R:F313	R:R:V357	10.49	Yes	No	0	6	7
506	R:R:L316	R:R:V320	2.98	Yes	No	13	9	7
507	R:R:L316	R:R:T345	2.95	Yes	No	13	9	9
508	R:R:L316	R:R:L348	4.15	Yes	No	0	9	9
509	R:R:I354	R:R:L316	7.14	Yes	Yes	0	6	9
510	R:R:N318	R:R:R321	7.23	No	No	0	8	8
511	R:R:T345	R:R:V320	4.76	No	No	13	9	7
512	R:R:K326	R:R:V322	3.04	No	No	0	9	8
513	R:R:L323	R:R:M327	2.83	No	Yes	0	9	7
514	R:R:M327	R:R:V324	3.04	Yes	No	0	7	5
515	R:R:E329	R:R:T325	5.64	No	No	0	6	7
516	R:R:E329	R:R:K326	2.7	No	No	0	6	9
517	R:R:E332	R:R:M327	12.18	No	Yes	8	5	7
518	R:R:M327	R:R:M337	5.78	Yes	Yes	8	7	7
519	R:R:K340	R:R:M327	4.32	No	Yes	0	8	7
520	R:R:E334	R:R:R328	8.14	No	No	8	6	6
521	R:R:M337	R:R:R328	8.69	Yes	No	8	7	6
522	R:R:E332	R:R:H336	13.54	No	No	0	5	6
523	R:R:E332	R:R:M337	5.41	No	Yes	8	5	7
524	R:R:E334	R:R:M337	2.71	No	Yes	8	6	7
525	R:R:E334	R:R:Y338	7.86	No	No	0	6	7
526	R:R:H336	R:R:K340	6.55	No	No	0	6	8
527	R:R:I347	R:R:I390	2.94	No	No	0	8	8
528	R:R:P350	R:R:V349	5.3	No	No	0	9	8
529	R:R:I354	R:R:V349	7.68	Yes	No	0	6	8
530	R:R:F386	R:R:P350	2.89	No	No	0	5	9
531	R:R:I390	R:R:P350	5.08	No	No	0	8	9
532	R:R:L351	R:R:L352	4.15	No	No	0	9	9
533	R:R:L351	R:R:Y391	22.27	No	No	0	9	8
534	R:R:I354	R:R:L352	2.85	Yes	No	0	6	9
535	R:R:F356	R:R:G353	3.01	Yes	No	0	7	9
536	R:R:F356	R:R:Q355	12.88	Yes	Yes	2	7	8
537	R:R:M376	R:R:Q355	2.72	Yes	Yes	2	7	8
538	R:R:L379	R:R:Q355	7.99	No	Yes	0	5	8
539	R:R:Q355	R:R:Q383	11.52	Yes	Yes	2	8	9
540	R:R:F356	R:R:I380	3.77	Yes	No	0	7	6
541	R:R:F356	R:R:Q383	4.68	Yes	Yes	2	7	9
542	R:R:F359	R:R:V358	5.24	Yes	No	0	6	5
543	R:R:F359	R:R:Y372	4.13	Yes	Yes	2	6	7
544	R:R:F359	R:R:M376	6.22	Yes	Yes	2	6	7
545	R:R:P363	R:R:R362	2.88	No	Yes	2	7	4
546	R:R:G369	R:R:R362	6	No	Yes	0	4	4
547	R:R:R362	R:R:Y372	7.2	Yes	Yes	2	4	7
548	R:R:D373	R:R:R362	11.91	No	Yes	0	5	4
549	R:R:L368	R:R:P363	3.28	No	No	0	3	7
550	R:R:P363	R:R:Y372	8.34	No	Yes	2	7	7
551	R:R:L368	R:R:N365	10.98	No	No	0	3	4
552	R:R:I371	R:R:M367	2.92	No	No	0	5	4
553	R:R:K370	R:R:Y374	4.78	No	Yes	5	4	6
554	R:R:M376	R:R:Y372	11.97	Yes	Yes	2	7	7
555	R:R:I380	R:R:M376	2.92	No	Yes	0	6	7
556	R:R:H377	R:R:H381	10.75	Yes	Yes	0	7	9
557	R:R:H381	R:R:I380	3.98	Yes	No	0	9	6
558	R:R:F382	R:R:F386	4.29	No	No	0	7	5
559	R:R:F385	R:R:F386	5.36	Yes	No	0	5	5
560	R:R:F385	R:R:T389	6.49	Yes	No	0	5	5
561	R:R:I390	R:R:Y391	8.46	No	No	0	8	8
562	R:R:C392	R:R:F393	5.59	No	Yes	12	9	8
563	R:R:N395	R:R:V398	8.87	No	No	0	9	9
564	R:R:N396	R:R:T400	2.92	No	No	0	6	4
565	R:R:Q405	R:R:T401	4.25	Yes	Yes	7	4	7
566	R:R:F409	R:R:W406	3.01	No	No	0	3	6
567	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
568	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
569	L:L:V32	R:R:F102	2.62	No	Yes	0	0	4
570	R:R:F173	R:R:V402	2.62	Yes	No	0	7	5
571	E:E:A77	E:E:W84	2.59	No	Yes	0	7	9
572	R:R:F224	R:R:T275	2.59	No	No	0	5	3
573	R:R:R404	R:R:T400	2.59	No	No	0	7	4
574	R:R:H201	R:R:L222	2.57	Yes	No	0	6	6
575	L:L:S20	R:R:Y146	2.54	No	Yes	0	0	2
576	R:R:F225	R:R:I221	2.51	No	No	0	5	4
577	E:E:T94	R:R:Y56	2.5	No	Yes	0	7	3
578	L:L:F15	R:R:K141	2.48	Yes	No	0	0	3
579	E:E:V137	R:R:W261	2.45	Yes	Yes	2	9	2
580	E:E:F62	E:E:L59	2.44	No	No	0	8	7
581	E:E:L39	E:E:R36	2.43	No	No	0	1	3
582	R:R:L62	R:R:R74	2.43	No	No	0	3	4
583	E:E:M47	E:E:Y65	2.39	No	No	0	4	5
584	R:R:L148	R:R:Y374	2.34	Yes	Yes	5	5	6
585	R:R:Q405	R:R:R404	2.34	Yes	No	0	4	7
586	E:E:E76	E:E:R36	2.33	Yes	No	0	6	3
587	R:R:E294	R:R:F94	2.33	No	No	0	3	3
588	R:R:F313	R:R:F314	2.14	Yes	No	0	6	5
589	E:E:R108	R:R:R58	2.13	No	Yes	0	4	3
590	L:L:Y37	R:R:R126	2.06	Yes	No	0	0	4
591	R:R:G116	R:R:P70	2.03	No	No	0	9	1
592	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
593	E:E:C28	E:E:G81	1.96	No	No	0	9	4
594	L:L:P28	L:L:P29	1.95	No	No	0	0	0
595	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
596	L:L:G24	L:L:S20	1.86	No	No	0	0	0
597	R:R:G44	R:R:V43	1.84	No	No	0	4	2
598	L:L:G33	L:L:T36	1.82	No	Yes	0	0	0
599	E:E:C28	E:E:V80	1.71	No	No	1	9	5
600	E:E:C82	E:E:V80	1.71	Yes	No	1	9	5
601	R:R:A333	R:R:S335	1.71	No	No	0	5	6
602	E:E:V127	R:R:A307	1.7	No	No	0	7	3
603	E:E:V131	R:R:A307	1.7	No	No	0	6	3
604	R:R:A251	R:R:V250	1.7	No	No	0	6	5
605	R:R:A341	R:R:V320	1.7	No	No	0	9	7
606	R:R:A341	R:R:V324	1.7	No	No	0	9	5
607	E:E:I125	E:E:P121	1.69	No	No	0	5	5
608	R:R:C394	R:R:T389	1.69	No	No	0	5	5
609	E:E:L37	E:E:P38	1.64	No	No	0	8	5
610	L:L:L27	L:L:P28	1.64	No	No	0	0	0
611	L:L:P29	R:R:N135	1.63	No	No	0	0	3
612	E:E:A43	E:E:M47	1.61	No	No	0	2	4
613	L:L:A5	R:R:M306	1.61	No	No	0	0	4
614	L:L:A5	R:R:M376	1.61	No	Yes	0	0	7
615	E:E:V124	E:E:V128	1.6	No	No	0	4	4
616	R:R:A344	R:R:L323	1.58	No	No	0	9	9
617	E:E:A77	E:E:N78	1.56	No	No	0	7	1
618	R:R:I199	R:R:S157	1.55	No	No	0	7	7
619	E:E:I120	E:E:V124	1.54	No	No	0	5	4
620	E:E:I125	E:E:V124	1.54	No	No	0	5	4
621	R:R:I153	R:R:V154	1.54	No	No	0	7	6
622	R:R:I199	R:R:V203	1.54	No	No	0	7	3
623	R:R:I371	R:R:V375	1.54	No	No	0	5	4
624	E:E:K142	E:E:S141	1.53	No	No	0	8	9
625	E:E:C40	E:E:E76	1.52	Yes	Yes	1	9	6
626	E:E:C72	E:E:E76	1.52	No	Yes	1	9	6
627	R:R:M346	R:R:V342	1.52	No	No	0	8	8
628	R:R:M346	R:R:T345	1.51	No	No	0	8	9
629	R:R:K110	R:R:T127	1.5	Yes	No	0	8	4
630	R:R:L379	R:R:V375	1.49	No	No	0	5	4
631	E:E:N29	E:E:V80	1.48	Yes	No	1	8	5
632	R:R:D113	R:R:V117	1.46	No	No	0	5	5
633	R:R:A333	R:R:H336	1.46	No	No	0	5	6
634	R:R:D103	R:R:T138	1.45	Yes	No	0	3	2
635	R:R:I347	R:R:K343	1.45	No	No	0	8	8
636	E:E:S102	R:R:Q60	1.44	No	No	0	7	3
637	R:R:F99	R:R:P100	1.44	Yes	No	0	5	4
638	R:R:F359	R:R:P360	1.44	Yes	No	0	6	5
639	E:E:E76	E:E:V79	1.43	Yes	No	0	6	1
640	E:E:T105	R:R:Q61	1.42	No	No	0	8	3
641	R:R:K120	R:R:N125	1.4	No	No	0	1	7
642	E:E:D46	E:E:M47	1.39	No	No	0	1	4
643	R:R:K403	R:R:Q399	1.36	No	No	0	6	7
644	L:L:N21	R:R:E210	1.31	No	No	0	0	3
645	R:R:R45	R:R:V42	1.31	No	No	0	7	1
646	R:R:A282	R:R:W290	1.3	No	Yes	0	3	9
647	E:E:V64	E:E:Y65	1.26	No	No	0	4	5
648	R:R:F225	R:R:I197	1.26	No	No	0	5	5
649	R:R:D83	R:R:R58	1.19	No	Yes	0	5	3
650	E:E:N103	E:E:W56	1.13	No	Yes	0	8	7
651	H:H:?202	R:R:R45	1.09	No	No	0	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:N29	10.5575	4	1	8
2	E:E:M33	3.63	4	1	8
3	E:E:C40	3.7425	4	1	9
4	E:E:F44	6.736	5	1	9
5	E:E:M48	8.6775	4	1	9
6	E:E:W56	7.9875	4	0	7
7	E:E:Y66	4.948	5	1	9
8	E:E:F69	6.15286	7	1	8
9	E:E:E76	1.7	4	1	6
10	E:E:C82	4.2375	4	1	9
11	E:E:W84	8.44	7	1	9
12	E:E:N86	3.772	5	1	9
13	E:E:F92	5.775	4	1	8
14	E:E:I93	7.125	4	1	9
15	E:E:H97	9.974	5	1	9
16	E:E:F100	6.538	5	1	8
17	E:E:F101	8.19857	7	1	9
18	E:E:D113	5.206	5	3	9
19	E:E:P114	8.092	5	3	9
20	E:E:V137	4.47	4	2	9
21	L:L:K1	5.8675	4	0	0
22	L:L:C2	5.365	4	2	0
23	L:L:T4	3.32	4	2	0
24	L:L:T6	6.02167	6	2	0
25	L:L:Q10	4.122	5	2	0
26	L:L:R11	3.67	4	2	0
27	L:L:F15	4.462	5	4	0
28	L:L:H18	7.346	5	6	0
29	L:L:K19	4.785	4	4	0
30	L:L:T36	4.1075	4	10	0
31	L:L:Y37	5.28429	7	1	0
32	L:L:?38	6.82	4	0	0
33	R:R:Q52	11.6575	4	1	6
34	R:R:Y53	8.664	5	1	1
35	R:R:Y56	6.24	7	1	3
36	R:R:R58	5.23	5	0	3
37	R:R:M59	5.54	4	0	5
38	R:R:Y65	10.16	4	1	3
39	R:R:W76	9.664	5	1	8
40	R:R:W79	8.59333	6	1	6
41	R:R:L80	8.838	5	1	5
42	R:R:W82	8.40714	7	1	9
43	R:R:D84	7.4675	4	1	4
44	R:R:T85	4.2	5	1	7
45	R:R:C95	5.3625	4	1	9
46	R:R:P96	7.218	5	1	9
47	R:R:Y98	8.014	5	1	4
48	R:R:F99	6.956	5	1	5
49	R:R:F102	6.94875	8	1	4
50	R:R:D103	5.48333	6	4	3
51	R:R:V108	6.6675	4	1	7
52	R:R:K110	13.68	4	1	8
53	R:R:W118	10.51	5	1	9
54	R:R:S129	7.79	4	1	7
55	R:R:Y131	8.63625	8	1	5
56	R:R:Y146	10.155	4	0	2
57	R:R:L148	6.8125	4	5	5
58	R:R:Y149	5.5675	4	0	5
59	R:R:H156	9.7525	4	0	7
60	R:R:L163	4.4875	4	0	8
61	R:R:F170	7.02	4	0	8
62	R:R:F173	5.914	5	7	7
63	R:R:L176	7.2525	4	7	9
64	R:R:V181	5.8625	4	0	9
65	R:R:L183	4.962	5	2	8
66	R:R:H184	6.2875	4	0	9
67	R:R:M187	6.225	4	2	8
68	R:R:Y191	8.92286	7	2	8
69	R:R:I198	6.288	5	0	7
70	R:R:H201	4.086	5	0	6
71	R:R:V212	3.84	4	6	3
72	R:R:H226	5.455	4	2	6
73	R:R:Q227	7.95	4	2	7
74	R:R:Y228	6.0525	4	2	8
75	R:R:M230	4.52	4	2	6
76	R:R:N233	7.23	5	2	9
77	R:R:Y234	8.604	5	2	7
78	R:R:F235	4.89	4	2	5
79	R:R:W236	8.87429	7	2	9
80	R:R:M237	4.81167	6	2	9
81	R:R:L238	4.17333	6	0	8
82	R:R:E240	7.89	4	0	9
83	R:R:I242	4.706	5	2	7
84	R:R:Y243	6.736	5	2	8
85	R:R:H245	10.43	4	0	8
86	R:R:I248	2.96	4	0	7
87	R:R:Q257	7.6725	4	2	5
88	R:R:L259	5.172	5	2	5
89	R:R:W261	5.802	5	2	2
90	R:R:Y262	4.885	8	2	7
91	R:R:L265	3.68	5	0	7
92	R:R:W267	8.75	5	2	9
93	R:R:F269	4.77	6	2	3
94	R:R:P270	3.332	5	2	9
95	R:R:R281	9.26	5	3	7
96	R:R:F285	8.21833	6	3	6
97	R:R:D287	5.786	5	3	3
98	R:R:C289	4.245	4	6	9
99	R:R:W290	9.99167	6	3	9
100	R:R:L291	3.2475	4	6	6
101	R:R:T295	9.15	4	3	4
102	R:R:L297	5.374	5	3	4
103	R:R:Y299	4.6775	4	0	7
104	R:R:I300	4.005	4	3	8
105	R:R:H302	6.37167	6	2	6
106	R:R:P304	4.185	4	0	9
107	R:R:F313	6.8475	4	0	6
108	R:R:L316	4.305	4	13	9
109	R:R:M327	5.63	5	8	7
110	R:R:M337	5.6475	4	8	7
111	R:R:I354	5.6725	4	0	6
112	R:R:Q355	8.7775	4	2	8
113	R:R:F356	6.64429	7	2	7
114	R:R:F359	4.2575	4	2	6
115	R:R:R362	6.00167	6	2	4
116	R:R:Y372	7.91	4	2	7
117	R:R:Y374	4.81	4	5	6
118	R:R:M376	5.088	5	2	7
119	R:R:H377	9.2475	4	5	7
120	R:R:H381	7.346	5	0	9
121	R:R:Q383	9.19	4	2	9
122	R:R:F385	7.3425	4	0	5
123	R:R:F393	5.295	4	12	8
124	R:R:T401	5.37	4	7	7
125	R:R:Q405	5.6575	4	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:I93	E:E:W84	26.7723	3.52	Yes	Yes	1	9	9
2	E:E:F69	E:E:I93	10.799	3.77	Yes	Yes	1	8	9
3	E:E:I93	R:R:Y56	14.0652	12.09	Yes	Yes	1	9	3
4	E:E:Y66	R:R:Y56	12.8351	3.97	Yes	Yes	1	9	3
5	E:E:W84	R:R:W76	21.4454	2.81	Yes	Yes	1	9	8
6	R:R:W76	R:R:Y56	27.3187	4.82	Yes	Yes	1	8	3
7	E:E:H97	R:R:Y56	14.4137	7.62	Yes	Yes	1	9	3
8	E:E:F101	E:E:F62	20.7966	9.65	Yes	No	0	9	8
9	E:E:F62	E:E:Y65	16.6419	4.13	No	No	0	8	5
10	E:E:W84	L:L:Y37	53.1004	3.86	Yes	Yes	1	9	0
11	R:R:M59	R:R:Y56	13.2562	4.79	Yes	Yes	0	5	3
12	L:L:?38	L:L:Y37	75.1224	2.9	Yes	Yes	0	0	0
13	L:L:?38	R:R:W128	97.0247	11.28	Yes	No	0	0	5
14	R:R:N130	R:R:W128	97.8712	11.3	No	No	0	8	5
15	R:R:N130	R:R:T109	98.2057	5.85	No	No	0	8	5
16	R:R:T109	R:R:Y92	97.737	6.24	No	No	11	5	4
17	R:R:K107	R:R:Y92	99.5202	8.36	No	No	0	3	4
18	R:R:F94	R:R:K107	99.843	7.44	No	No	0	3	3
19	R:R:E294	R:R:F94	100	2.33	No	No	0	3	3
20	L:L:K1	R:R:E294	92.8522	12.15	Yes	No	0	0	3
21	L:L:K1	R:R:V293	78.2812	4.55	Yes	No	0	0	6
22	R:R:L298	R:R:V293	78.428	2.98	No	No	0	6	6
23	R:R:H302	R:R:L298	77.7757	3.86	Yes	No	2	6	6
24	R:R:H302	R:R:M230	52.9062	6.57	Yes	Yes	2	6	6
25	R:R:M230	R:R:N194	37.0456	2.8	Yes	No	0	6	8
26	R:R:N194	R:R:N233	46.7087	4.09	No	Yes	0	8	9
27	R:R:N233	R:R:T190	23.7558	8.77	Yes	No	2	9	9
28	R:R:T190	R:R:W236	17.5728	6.06	No	Yes	2	9	9
29	R:R:C239	R:R:W236	10.0429	7.84	No	Yes	0	7	9
30	L:L:T6	R:R:H302	24.2698	9.58	Yes	Yes	2	0	6
31	L:L:T6	R:R:Y234	20.4472	8.74	Yes	Yes	2	0	7
32	R:R:M237	R:R:Y234	40.4038	4.79	Yes	Yes	2	9	7
33	R:R:M187	R:R:M237	30.7714	2.89	Yes	Yes	2	8	9
34	R:R:E240	R:R:M187	50.0512	10.83	Yes	Yes	0	9	8
35	R:R:E240	R:R:L183	20.5715	5.3	Yes	Yes	0	9	8
36	R:R:L183	R:R:Y262	14.9034	4.69	Yes	Yes	2	8	7
37	R:R:M230	R:R:Y234	19.749	5.99	Yes	Yes	2	6	7
38	R:R:M187	R:R:N233	18.1763	2.8	Yes	Yes	2	8	9
39	L:L:K1	L:L:R11	11.5428	3.71	Yes	Yes	0	0	0
40	R:R:I198	R:R:N194	10.6753	5.66	Yes	No	0	7	8
41	L:L:Y37	R:R:G78	21.172	7.24	Yes	No	0	0	5
42	R:R:G78	R:R:W76	20.9159	7.04	No	Yes	0	5	8
43	L:L:?38	R:R:Y131	22.514	5.8	Yes	Yes	0	0	5
44	R:R:M59	R:R:R74	17.8374	8.69	Yes	No	0	5	4
45	R:R:L62	R:R:R74	11.8288	2.43	No	No	0	3	4
46	R:R:Q383	R:R:Y191	12.2472	12.4	Yes	Yes	2	9	8
47	R:R:L163	R:R:Y191	20.3271	5.86	Yes	Yes	0	8	8
48	R:R:A388	R:R:L163	12.4588	3.15	No	Yes	0	8	8
49	R:R:M237	R:R:Y191	10.5452	5.99	Yes	Yes	2	9	8
50	R:R:E240	R:R:H184	16.0376	6.15	Yes	Yes	0	9	9
51	R:R:H184	R:R:R180	10.1868	7.9	Yes	No	0	9	9
52	R:R:E240	R:R:L351	17.8746	9.28	Yes	No	0	9	9
53	R:R:L351	R:R:L352	15.4952	4.15	No	No	0	9	9
54	R:R:I354	R:R:L352	15.0157	2.85	Yes	No	0	6	9
55	R:R:I354	R:R:L316	11.5528	7.14	Yes	Yes	0	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:E74	E:E:W84	23.99	1	No	Yes	5	9	1	1
E:E:E74	L:L:Y37	5.61	1	No	Yes	5	0	1	0
E:E:Y83	R:R:R126	21.61	0	No	No	6	4	2	1
E:E:P85	E:E:W84	18.92	1	No	Yes	9	9	1	1
E:E:N86	E:E:W84	3.39	1	Yes	Yes	9	9	2	1
E:E:I93	E:E:W84	3.52	1	Yes	Yes	9	9	2	1
E:E:W84	L:L:Y37	3.86	1	Yes	Yes	9	0	1	0
E:E:W84	R:R:W76	2.81	1	Yes	Yes	9	8	1	2
E:E:P85	L:L:Y37	2.78	1	No	Yes	9	0	1	0
E:E:I123	R:R:Y299	3.63	0	No	Yes	9	7	2	1
L:L:K1	R:R:S105	3.06	0	Yes	No	0	1	0	1
L:L:K1	R:R:V293	4.55	0	Yes	No	0	6	0	1
L:L:K1	R:R:E294	12.15	0	Yes	No	0	3	0	1
L:L:C2	R:R:L298	3.17	2	Yes	No	0	6	0	1
L:L:C2	R:R:Y299	8.06	2	Yes	Yes	0	7	0	1
L:L:C2	R:R:H302	2.95	2	Yes	Yes	0	6	0	1
L:L:N3	R:R:W361	18.08	2	No	No	0	4	0	1
L:L:N3	R:R:R362	4.82	2	No	Yes	0	4	0	1
L:L:T4	R:R:Y299	3.75	2	Yes	Yes	0	7	0	1
L:L:T4	R:R:M306	3.01	2	Yes	No	0	4	0	1
L:L:T6	R:R:Y234	8.74	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	9.58	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	4.76	2	Yes	No	0	7	0	1
L:L:T6	R:R:M306	6.02	2	Yes	No	0	4	0	1
L:L:T6	R:R:F356	3.89	2	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	10.32	2	No	Yes	0	6	0	1
L:L:A8	R:R:H377	4.39	0	No	Yes	0	7	0	1
L:L:T9	R:R:I198	3.04	0	No	Yes	0	7	0	1
L:L:T9	R:R:H381	2.74	0	No	Yes	0	9	0	1
L:L:Q10	R:R:H226	3.71	2	Yes	Yes	0	6	0	1
L:L:Q10	R:R:Q227	6.4	2	Yes	Yes	0	7	0	1
L:L:Q10	R:R:M230	2.72	2	Yes	Yes	0	6	0	1
L:L:Q10	R:R:H302	4.95	2	Yes	Yes	0	6	0	1
L:L:R11	R:R:R362	3.2	2	Yes	Yes	0	4	0	1
L:L:L12	R:R:L148	2.77	5	No	Yes	0	5	0	1
L:L:L12	R:R:H377	5.14	5	No	Yes	0	7	0	1
L:L:A13	R:R:H201	2.93	0	No	Yes	0	6	0	1
L:L:N14	R:R:V293	5.91	0	No	No	0	6	0	1
L:L:F15	R:R:D103	5.97	4	Yes	Yes	0	3	0	1
L:L:F15	R:R:L142	3.65	4	Yes	No	0	2	0	1
L:L:F15	R:R:A145	2.77	4	Yes	No	0	4	0	1
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
L:L:L16	R:R:Y146	8.21	0	No	Yes	0	2	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:V17	R:R:V212	4.81	6	No	Yes	0	3	0	1
L:L:V17	R:R:L291	2.98	6	No	Yes	0	6	0	1
L:L:H18	R:R:D97	5.04	6	Yes	No	0	2	0	1
L:L:H18	R:R:G209	3.18	6	Yes	No	0	3	0	1
L:L:H18	R:R:V212	4.15	6	Yes	Yes	0	3	0	1
L:L:H18	R:R:R213	14.67	6	Yes	No	0	2	0	1
L:L:K19	R:R:D103	5.53	4	Yes	Yes	0	3	0	1
L:L:K19	R:R:P104	3.35	4	Yes	No	0	3	0	1
L:L:K19	R:R:L142	2.82	4	Yes	No	0	2	0	1
L:L:F23	R:R:Y146	21.66	0	No	Yes	0	2	0	1
L:L:F23	R:R:Y150	8.25	0	No	No	0	4	0	1
L:L:T30	R:R:F99	5.19	1	No	Yes	0	5	0	1
L:L:T30	R:R:D101	4.34	1	No	No	0	4	0	1
L:L:T30	R:R:F102	3.89	1	No	Yes	0	4	0	1
L:L:V32	R:R:N135	7.39	0	No	No	0	3	0	1
L:L:S34	R:R:H121	13.95	0	No	No	0	4	0	1
L:L:S34	R:R:E123	7.19	0	No	No	0	4	0	1
L:L:Y37	R:R:G78	7.24	1	Yes	No	0	5	0	1
L:L:Y37	R:R:W79	12.54	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:W128	11.28	0	Yes	No	0	5	0	1
L:L:?38	R:R:Y131	5.8	0	Yes	Yes	0	5	0	1
R:R:R213	R:R:V43	6.54	0	No	No	2	2	1	2
R:R:M48	R:R:W79	5.82	1	No	Yes	6	6	2	1
R:R:M48	R:R:Y98	10.78	1	No	Yes	6	4	2	2
R:R:G78	R:R:W76	7.04	0	No	Yes	5	8	1	2
R:R:D77	R:R:S129	7.36	1	No	Yes	9	7	2	2
R:R:D77	R:R:Y131	11.49	1	No	Yes	9	5	2	1
R:R:W79	R:R:Y98	4.82	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	6.01	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	17.36	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:P96	9.85	1	Yes	Yes	5	9	2	2
R:R:L80	R:R:V108	4.47	1	Yes	Yes	5	7	2	2
R:R:L80	R:R:Y131	8.21	1	Yes	Yes	5	5	2	1
R:R:C95	R:R:P96	3.77	1	Yes	Yes	9	9	2	2
R:R:C95	R:R:F102	6.98	1	Yes	Yes	9	4	2	1
R:R:C95	R:R:V108	3.42	1	Yes	Yes	9	7	2	2
R:R:C134	R:R:C95	7.28	1	No	Yes	9	9	2	2
R:R:P96	R:R:Y98	12.52	1	Yes	Yes	9	4	2	2
R:R:F102	R:R:P96	5.78	1	Yes	Yes	4	9	1	2
R:R:P96	R:R:Y131	4.17	1	Yes	Yes	9	5	2	1
R:R:D97	R:R:P104	4.83	0	No	No	2	3	1	1
R:R:F99	R:R:Y98	9.28	1	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	12.86	1	Yes	Yes	4	5	1	1
R:R:F102	R:R:Y131	3.09	1	Yes	Yes	4	5	1	1
R:R:C134	R:R:F102	15.36	1	No	Yes	9	4	2	1
R:R:D103	R:R:P104	6.44	4	Yes	No	3	3	1	1
R:R:D103	R:R:S105	4.42	4	Yes	No	3	1	1	1
R:R:D103	R:R:E106	9.09	4	Yes	No	3	4	1	2
R:R:E106	R:R:S105	2.87	4	No	No	4	1	2	1
R:R:V108	R:R:Y131	13.88	1	Yes	Yes	7	5	2	1
R:R:H121	R:R:P122	9.15	0	No	No	4	5	1	2
R:R:H121	R:R:W128	25.39	0	No	No	4	5	1	1
R:R:N130	R:R:W128	11.3	0	No	No	8	5	2	1
R:R:S129	R:R:Y131	5.09	1	Yes	Yes	7	5	2	1
R:R:F137	R:R:K141	4.96	0	No	No	1	3	2	1
R:R:K141	R:R:K366	5.75	0	No	No	3	3	1	2
R:R:L142	R:R:Y146	8.21	4	No	Yes	2	2	1	1
R:R:D373	R:R:L148	5.43	0	No	Yes	5	5	2	1
R:R:H377	R:R:L148	16.71	5	Yes	Yes	7	5	1	1
R:R:Y149	R:R:Y150	8.94	0	Yes	No	5	4	1	1
R:R:L202	R:R:Y149	7.03	0	No	Yes	7	5	2	1
R:R:P207	R:R:Y149	2.78	0	No	Yes	3	5	2	1
R:R:I153	R:R:Y150	4.84	0	No	No	7	4	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	13.26	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	11.94	0	Yes	Yes	7	9	2	1
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:M230	R:R:N194	2.8	2	Yes	No	6	8	1	2
R:R:H226	R:R:I197	5.3	2	Yes	No	6	5	1	2
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	2
R:R:H226	R:R:I198	6.63	2	Yes	Yes	6	7	1	1
R:R:H201	R:R:V205	8.3	0	Yes	No	6	7	1	2
R:R:H201	R:R:V206	2.77	0	Yes	No	6	3	1	2
R:R:H201	R:R:L291	3.86	0	Yes	Yes	6	6	1	1
R:R:P207	R:R:V206	5.3	0	No	No	3	3	2	2
R:R:E210	R:R:N208	3.94	0	No	No	3	3	1	2
R:R:C289	R:R:V212	3.42	6	Yes	Yes	9	3	2	1
R:R:L291	R:R:V212	2.98	6	Yes	Yes	6	3	1	1
R:R:H223	R:R:Q227	12.36	0	No	Yes	5	7	2	1
R:R:H226	R:R:Q227	6.18	2	Yes	Yes	6	7	1	1
R:R:I301	R:R:Q227	6.86	0	No	Yes	7	7	2	1
R:R:M230	R:R:Y234	5.99	2	Yes	Yes	6	7	1	1
R:R:H302	R:R:M230	6.57	2	Yes	Yes	6	6	1	1
R:R:M237	R:R:Y234	4.79	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	10.09	2	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	13.41	2	Yes	Yes	7	7	1	1
R:R:L309	R:R:M237	2.83	0	No	Yes	7	9	2	2
R:R:M237	R:R:Q383	8.16	2	Yes	Yes	9	9	2	2
R:R:C289	R:R:L291	3.17	6	Yes	Yes	9	6	2	1
R:R:E294	R:R:S292	2.87	0	No	No	3	4	1	2
R:R:L298	R:R:V293	2.98	2	No	No	6	6	1	1
R:R:H296	R:R:Y299	3.27	0	No	Yes	2	7	2	1
R:R:H302	R:R:L298	3.86	2	Yes	No	6	6	1	1
R:R:F356	R:R:L309	4.87	2	Yes	No	7	7	1	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	12.88	2	Yes	Yes	7	8	1	2
R:R:M376	R:R:Q355	2.72	2	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	11.52	2	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	3.77	2	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	2	Yes	Yes	7	9	1	2
R:R:F359	R:R:Y372	4.13	2	Yes	Yes	6	7	2	2
R:R:F359	R:R:M376	6.22	2	Yes	Yes	6	7	2	1
R:R:P363	R:R:R362	2.88	2	No	Yes	7	4	2	1
R:R:G369	R:R:R362	6	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	7.2	2	Yes	Yes	4	7	1	2
R:R:D373	R:R:R362	11.91	0	No	Yes	5	4	2	1
R:R:P363	R:R:Y372	8.34	2	No	Yes	7	7	2	2
R:R:M376	R:R:Y372	11.97	2	Yes	Yes	7	7	1	2
R:R:I380	R:R:M376	2.92	0	No	Yes	6	7	2	1
R:R:H377	R:R:H381	10.75	5	Yes	Yes	7	9	1	1
R:R:H381	R:R:I380	3.98	0	Yes	No	9	6	1	2
L:L:V32	R:R:F102	2.62	0	No	Yes	0	4	0	1
E:E:A77	E:E:W84	2.59	0	No	Yes	7	9	2	1
R:R:H201	R:R:L222	2.57	0	Yes	No	6	6	1	2
L:L:S20	R:R:Y146	2.54	0	No	Yes	0	2	0	1
L:L:F15	R:R:K141	2.48	4	Yes	No	0	3	0	1
R:R:L148	R:R:Y374	2.34	5	Yes	Yes	5	6	1	2
R:R:E294	R:R:F94	2.33	0	No	No	3	3	1	2
L:L:Y37	R:R:R126	2.06	1	Yes	No	0	4	0	1
L:L:P29	R:R:N135	1.63	0	No	No	0	3	0	1
L:L:A5	R:R:M306	1.61	0	No	No	0	4	0	1
L:L:A5	R:R:M376	1.61	0	No	Yes	0	7	0	1
R:R:D103	R:R:T138	1.45	4	Yes	No	3	2	1	2
R:R:F99	R:R:P100	1.44	1	Yes	No	5	4	1	2
L:L:N21	R:R:E210	1.31	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F2A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.7
Number of Linked Nodes	497
Number of Links	651
Number of Hubs	125
Number of Links mediated by Hubs	438
Number of Communities	13
Number of Nodes involved in Communities	172
Number of Links involved in Communities	268

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	512705
Length Of Smallest Path	3
Average Path Length	21.437
Length of Longest Path	40
Minimum Path Strength	1.2
Average Path Strength	6.35587
Maximum Path Strength	21.455
Minimum Path Correlation	0.7
Average Path Correlation	0.960545
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	47.6435
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.9246
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of protein localization to plasma membrane • protein localization • regulation of localization • cellular localization • regulation of protein localization • cellular macromolecule localization • regulation of protein localization to membrane • positive regulation of protein localization to cell periphery • protein localization to cell periphery • protein localization to plasma membrane • positive regulation of protein localization to membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of protein localization to plasma membrane • establishment of protein localization • nitrogen compound transport • protein transport • regulation of signaling receptor activity • negative regulation of molecular function • regulation of molecular function • cross-receptor inhibition within G protein-coupled receptor heterodimer • G protein-coupled receptor signaling pathway • negative regulation of signaling receptor activity • regulation of G protein-coupled receptor signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of receptor recycling • receptor recycling • receptor metabolic process • positive regulation of receptor recycling • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • heart process • multicellular organismal process • system process • circulatory system process • G protein-coupled receptor signaling pathway involved in heart process • intracellular transport • establishment of localization in cell • intracellular protein transport • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • amylin receptor signaling pathway • response to lipid • cellular response to oxygen-containing compound • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex
Gene Ontology	Cellular Component	• cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • lytic vacuole • vacuole • cytoplasm • intracellular membrane-bounded organelle • lysosome • amylin receptor complex • amylin receptor complex 3 • protein binding • binding • signaling receptor binding • amide binding • amyloid-beta binding • peptide binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • multicellular organismal process • eating behavior • feeding behavior • cell-cell signaling • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • regulation of primary metabolic process • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of supramolecular fiber organization • metabolic process • macromolecule metabolic process • supramolecular fiber organization • regulation of metabolic process • amylin receptor 3 signaling pathway • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • regulation of biosynthetic process • mRNA catabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • regulation of mRNA metabolic process • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to hormone stimulus • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?201 H:H:?202
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP3
UniProt	O60896
Sequence	>8F2A_nogp_Chain_E C N E T G M L E R L P L C G K A F A D M M G K V D V W K W C N L S E F I V Y Y E S F T N C T E M E A N V V G C Y W P N P L A Q G F I T G I H R Q F F S N C T V D R V H L E D P P D E V L I P L I V I P V V L T V A M A G L V V W R S K R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>8F2A_nogp_Chain_R Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	10.1038/s41589-023-01393-4
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	10.1038/s41589-023-01393-4
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	10.1126/science.abm9609

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