psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C28	E:E:C82	7.28	No	Yes	1	9	9
2	E:E:N29	E:E:T31	4.39	Yes	No	1	8	7
3	E:E:G32	E:E:N29	6.79	No	Yes	1	3	8
4	E:E:N29	H:H:?201	29.57	Yes	No	1	8	0
5	E:E:E30	E:E:T31	2.82	No	No	0	7	7
6	E:E:T31	H:H:?201	2.65	No	No	1	7	0
7	E:E:G32	H:H:?201	3.07	No	No	1	3	0
8	E:E:L37	E:E:M33	5.65	No	Yes	0	8	8
9	E:E:C82	E:E:M33	3.24	Yes	Yes	1	9	8
10	E:E:M33	E:E:N86	2.8	Yes	Yes	1	8	9
11	E:E:L88	E:E:M33	2.83	No	Yes	0	6	8
12	E:E:L34	E:E:L88	6.92	No	No	0	5	6
13	E:E:F92	E:E:L37	10.96	Yes	No	0	8	8
14	E:E:C40	E:E:F69	2.79	Yes	Yes	1	9	8
15	E:E:C40	E:E:C72	7.28	Yes	No	1	9	9
16	E:E:C40	E:E:T73	3.38	Yes	No	1	9	9
17	E:E:F69	E:E:G41	3.01	Yes	No	1	8	7
18	E:E:F92	E:E:G41	3.01	Yes	No	1	8	7
19	E:E:F44	E:E:M48	4.98	Yes	Yes	1	9	9
20	E:E:F44	E:E:Y66	6.19	Yes	Yes	1	9	9
21	E:E:F44	E:E:F69	12.86	Yes	Yes	1	9	8
22	E:E:F100	E:E:F44	5.36	Yes	Yes	1	8	9
23	E:E:F101	E:E:F44	4.29	Yes	Yes	1	9	9
24	E:E:A45	E:E:F100	2.77	No	Yes	0	5	8
25	E:E:M48	E:E:W56	19.78	Yes	Yes	0	9	7
26	E:E:F100	E:E:M48	6.22	Yes	Yes	1	8	9
27	E:E:F101	E:E:M48	3.73	Yes	Yes	1	9	9
28	E:E:V51	E:E:W56	3.68	No	Yes	0	6	7
29	E:E:D52	E:E:K55	4.15	No	No	0	6	4
30	E:E:V53	E:E:W56	7.36	No	Yes	0	4	7
31	E:E:K55	E:E:N58	6.99	No	No	0	4	8
32	E:E:C104	E:E:C57	7.28	No	No	0	9	9
33	E:E:F62	E:E:Y65	4.13	No	No	0	8	5
34	E:E:F101	E:E:F62	9.65	Yes	No	0	9	8
35	E:E:I63	E:E:V64	3.07	No	No	0	6	4
36	E:E:I63	R:R:K46	4.36	No	No	0	6	4
37	E:E:I63	R:R:D50	2.8	No	No	0	6	2
38	E:E:H97	E:E:Y66	6.53	Yes	Yes	1	9	9
39	E:E:F101	E:E:Y66	3.09	Yes	Yes	1	9	9
40	E:E:Y66	R:R:Y53	4.96	Yes	Yes	1	9	1
41	E:E:Y66	R:R:Y56	3.97	Yes	Yes	1	9	3
42	E:E:E67	R:R:R45	12.79	No	No	0	4	7
43	E:E:E67	R:R:M49	21.65	No	No	0	4	4
44	E:E:F69	E:E:T73	6.49	Yes	No	1	8	9
45	E:E:F69	E:E:F92	5.36	Yes	Yes	1	8	8
46	E:E:F69	E:E:I93	3.77	Yes	Yes	1	8	9
47	E:E:F69	E:E:I96	8.79	Yes	No	1	8	6
48	E:E:T70	R:R:M49	6.02	No	No	1	9	4
49	E:E:T70	R:R:Q52	12.76	No	Yes	1	9	6
50	E:E:M75	E:E:N71	8.41	No	No	10	1	4
51	E:E:N71	H:H:?202	30.8	No	No	10	4	0
52	E:E:I93	E:E:T73	9.12	Yes	No	1	9	9
53	E:E:E74	E:E:W84	23.99	No	Yes	1	5	9
54	E:E:E74	L:L:Y37	5.61	No	Yes	1	5	0
55	E:E:M75	H:H:?202	15.22	No	No	10	1	0
56	E:E:C82	E:E:N86	4.72	Yes	Yes	1	9	9
57	E:E:Y83	R:R:N124	9.3	No	No	0	6	5
58	E:E:Y83	R:R:R126	21.61	No	No	0	6	4
59	E:E:P85	E:E:W84	18.92	No	Yes	1	9	9
60	E:E:N86	E:E:W84	3.39	Yes	Yes	1	9	9
61	E:E:I93	E:E:W84	3.52	Yes	Yes	1	9	9
62	E:E:W84	L:L:Y37	3.86	Yes	Yes	1	9	0
63	E:E:W84	R:R:W76	2.81	Yes	Yes	1	9	8
64	E:E:P85	L:L:Y37	2.78	No	Yes	1	9	0
65	E:E:N86	E:E:P87	3.26	Yes	No	0	9	5
66	E:E:A89	E:E:N86	4.69	No	Yes	0	8	9
67	E:E:Q90	R:R:M59	5.44	No	Yes	0	9	5
68	E:E:Q90	R:R:T75	4.25	No	No	0	9	5
69	E:E:G91	E:E:T94	3.64	No	No	0	4	7
70	E:E:F92	E:E:I96	3.77	Yes	No	1	8	6
71	E:E:I93	R:R:Y56	12.09	Yes	Yes	1	9	3
72	E:E:G95	E:E:R98	3	No	No	0	3	6
73	E:E:F101	E:E:H97	15.84	Yes	Yes	1	9	9
74	E:E:H97	R:R:Y53	9.8	Yes	Yes	1	9	1
75	E:E:H97	R:R:Y56	7.62	Yes	Yes	1	9	3
76	E:E:H97	R:R:D57	10.08	Yes	No	1	9	4
77	E:E:Q99	E:E:R98	4.67	No	No	0	4	6
78	E:E:R98	R:R:Q60	7.01	No	No	0	6	3
79	E:E:F100	E:E:Q99	14.05	Yes	No	0	8	4
80	E:E:F100	E:E:F101	4.29	Yes	Yes	1	8	9
81	E:E:F101	R:R:Y53	16.5	Yes	Yes	1	9	1
82	E:E:C104	E:E:N103	9.45	No	No	0	9	8
83	E:E:V106	R:R:Y53	6.31	No	Yes	1	4	1
84	E:E:V106	R:R:D57	4.38	No	No	1	4	4
85	E:E:L111	E:E:V109	5.96	No	No	0	4	5
86	E:E:E112	E:E:H110	9.85	No	No	0	4	4
87	E:E:L111	R:R:F285	8.53	No	Yes	3	4	6
88	E:E:L111	R:R:D287	2.71	No	Yes	3	4	3
89	E:E:D113	E:E:P114	4.83	Yes	Yes	3	9	9
90	E:E:D113	R:R:F285	4.78	Yes	Yes	3	9	6
91	E:E:D113	R:R:T295	8.67	Yes	Yes	3	9	4
92	E:E:D113	R:R:H296	5.04	Yes	No	0	9	2
93	E:E:D113	R:R:L297	2.71	Yes	Yes	3	9	4
94	E:E:P114	E:E:V118	3.53	Yes	No	0	9	7
95	E:E:L119	E:E:P114	3.28	No	Yes	0	9	9
96	E:E:P114	R:R:Y284	22.25	Yes	No	0	9	2
97	E:E:P114	R:R:L297	6.57	Yes	Yes	3	9	4
98	E:E:E117	E:E:P115	6.29	No	No	0	4	8
99	E:E:P115	E:E:V118	3.53	No	No	0	8	7
100	E:E:D116	E:E:L119	2.71	No	No	0	6	9
101	E:E:I123	E:E:L119	4.28	No	No	0	9	9
102	E:E:I120	E:E:P121	3.39	No	No	0	5	5
103	E:E:L122	R:R:T280	4.42	No	No	3	9	4
104	E:E:L122	R:R:I300	5.71	No	Yes	3	9	8
105	E:E:I123	R:R:Y299	3.63	No	Yes	0	9	7
106	E:E:I125	E:E:P126	3.39	No	No	0	5	9
107	E:E:P126	R:R:P304	3.9	No	Yes	0	9	9
108	E:E:V127	R:R:P304	3.53	No	Yes	0	7	9
109	E:E:L129	R:R:F269	3.65	No	Yes	0	7	3
110	E:E:T130	R:R:F235	7.78	No	Yes	2	9	5
111	E:E:T130	R:R:F269	3.89	No	Yes	2	9	3
112	E:E:T130	R:R:P304	5.25	No	Yes	0	9	9
113	E:E:M133	R:R:L264	2.83	No	No	0	9	3
114	E:E:M133	R:R:L265	4.24	No	Yes	0	9	7
115	E:E:M133	R:R:F269	7.46	No	Yes	0	9	3
116	E:E:A134	R:R:L238	4.73	No	Yes	0	8	8
117	E:E:L136	R:R:W261	4.56	No	Yes	0	6	2
118	E:E:V137	R:R:I242	6.14	Yes	Yes	2	9	7
119	E:E:V137	R:R:Y262	6.31	Yes	Yes	2	9	7
120	E:E:V137	R:R:L265	2.98	Yes	Yes	0	9	7
121	E:E:V138	R:R:I242	3.07	No	Yes	0	9	7
122	E:E:V138	R:R:V250	3.21	No	No	0	9	5
123	E:E:R140	E:E:W139	5	No	No	2	8	9
124	E:E:R143	E:E:W139	3	No	No	2	8	9
125	E:E:T144	E:E:W139	12.13	No	No	0	7	9
126	E:E:R140	E:E:R143	19.19	No	No	2	8	8
127	E:E:R140	R:R:W261	10	No	Yes	2	8	2
128	E:E:S141	R:R:Q257	8.66	No	Yes	2	9	5
129	E:E:S141	R:R:Y262	5.09	No	Yes	2	9	7
130	E:E:K142	R:R:T254	19.52	No	No	0	8	6
131	H:H:?1	R:R:N73	29.57	No	No	0	0	4
132	H:H:?2	R:R:W128	7.15	No	Yes	4	0	5
133	H:H:?2	R:R:N130	29.57	No	Yes	4	0	8
134	H:H:?2	R:R:T132	13.23	No	No	4	0	6
135	L:L:K1	L:L:R11	3.71	Yes	Yes	0	0	0
136	L:L:K1	R:R:S105	3.06	Yes	No	0	0	1
137	L:L:K1	R:R:V293	4.55	Yes	No	0	0	6
138	L:L:K1	R:R:E294	12.15	Yes	No	0	0	3
139	L:L:C2	L:L:C7	7.28	Yes	No	2	0	0
140	L:L:C2	R:R:L298	3.17	Yes	No	2	0	6
141	L:L:C2	R:R:Y299	8.06	Yes	Yes	0	0	7
142	L:L:C2	R:R:H302	2.95	Yes	Yes	2	0	6
143	L:L:N3	L:L:R11	3.62	No	Yes	2	0	0
144	L:L:N3	R:R:W361	18.08	No	No	0	0	4
145	L:L:N3	R:R:R362	4.82	No	Yes	2	0	4
146	L:L:T4	L:L:T6	3.14	Yes	Yes	2	0	0
147	L:L:C7	L:L:T4	3.38	No	Yes	2	0	0
148	L:L:T4	R:R:Y299	3.75	Yes	Yes	0	0	7
149	L:L:T4	R:R:M306	3.01	Yes	No	2	0	4
150	L:L:T6	R:R:Y234	8.74	Yes	Yes	2	0	7
151	L:L:T6	R:R:H302	9.58	Yes	Yes	2	0	6
152	L:L:T6	R:R:V305	4.76	Yes	No	2	0	7
153	L:L:T6	R:R:M306	6.02	Yes	No	2	0	4
154	L:L:T6	R:R:F356	3.89	Yes	Yes	2	0	7
155	L:L:C7	R:R:H302	10.32	No	Yes	2	0	6
156	L:L:A8	L:L:R11	4.15	No	Yes	0	0	0
157	L:L:A8	R:R:H377	4.39	No	Yes	0	0	7
158	L:L:Q10	L:L:T9	2.83	Yes	No	0	0	0
159	L:L:T9	R:R:I198	3.04	No	Yes	0	0	7
160	L:L:T9	R:R:H381	2.74	No	Yes	0	0	9
161	L:L:Q10	R:R:H226	3.71	Yes	Yes	2	0	6
162	L:L:Q10	R:R:Q227	6.4	Yes	Yes	2	0	7
163	L:L:Q10	R:R:M230	2.72	Yes	Yes	2	0	6
164	L:L:Q10	R:R:H302	4.95	Yes	Yes	2	0	6
165	L:L:R11	R:R:R362	3.2	Yes	Yes	2	0	4
166	L:L:L12	R:R:L148	2.77	No	Yes	6	0	5
167	L:L:L12	R:R:H377	5.14	No	Yes	6	0	7
168	L:L:A13	R:R:H201	2.93	No	Yes	0	0	6
169	L:L:N14	R:R:V293	5.91	No	No	0	0	6
170	L:L:F15	L:L:K19	7.44	Yes	Yes	5	0	0
171	L:L:F15	R:R:D103	5.97	Yes	Yes	5	0	3
172	L:L:F15	R:R:L142	3.65	Yes	No	5	0	2
173	L:L:F15	R:R:A145	2.77	Yes	No	0	0	4
174	L:L:L16	R:R:A145	3.15	No	No	0	0	4
175	L:L:L16	R:R:Y146	8.21	No	Yes	0	0	2
176	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
177	L:L:H18	L:L:V17	9.69	Yes	No	7	0	0
178	L:L:V17	R:R:V212	4.81	No	Yes	7	0	3
179	L:L:V17	R:R:L291	2.98	No	Yes	7	0	6
180	L:L:H18	R:R:D97	5.04	Yes	No	0	0	2
181	L:L:H18	R:R:G209	3.18	Yes	No	0	0	3
182	L:L:H18	R:R:V212	4.15	Yes	Yes	7	0	3
183	L:L:H18	R:R:R213	14.67	Yes	No	0	0	2
184	L:L:K19	R:R:D103	5.53	Yes	Yes	5	0	3
185	L:L:K19	R:R:P104	3.35	Yes	No	5	0	3
186	L:L:K19	R:R:L142	2.82	Yes	No	5	0	2
187	L:L:F23	R:R:Y146	21.66	No	Yes	0	0	2
188	L:L:F23	R:R:Y150	8.25	No	No	0	0	4
189	L:L:G24	L:L:P25	4.06	No	No	0	0	0
190	L:L:I26	L:L:L27	5.71	No	No	0	0	0
191	L:L:T30	R:R:F99	5.19	No	Yes	1	0	5
192	L:L:T30	R:R:D101	4.34	No	No	0	0	4
193	L:L:T30	R:R:F102	3.89	No	Yes	1	0	4
194	L:L:N31	L:L:N35	8.17	No	No	11	0	0
195	L:L:N31	L:L:T36	4.39	No	Yes	11	0	0
196	L:L:V32	R:R:N135	7.39	No	No	0	0	3
197	L:L:S34	R:R:H121	13.95	No	No	0	0	4
198	L:L:S34	R:R:E123	7.19	No	No	0	0	4
199	L:L:N35	L:L:T36	2.92	No	Yes	11	0	0
200	L:L:?38	L:L:T36	7.3	Yes	Yes	0	0	0
201	L:L:?38	L:L:Y37	2.9	Yes	Yes	0	0	0
202	L:L:Y37	R:R:G78	7.24	Yes	No	0	0	5
203	L:L:Y37	R:R:W79	12.54	Yes	Yes	1	0	6
204	L:L:?38	R:R:W128	11.28	Yes	Yes	0	0	5
205	L:L:?38	R:R:Y131	5.8	Yes	Yes	0	0	5
206	R:R:R213	R:R:V43	6.54	No	No	0	2	2
207	R:R:M48	R:R:W79	5.82	No	Yes	1	6	6
208	R:R:M48	R:R:Y98	10.78	No	Yes	1	6	4
209	R:R:M49	R:R:Q52	4.08	No	Yes	1	4	6
210	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
211	R:R:Q52	R:R:Y56	7.89	Yes	Yes	1	6	3
212	R:R:Q52	R:R:W76	21.9	Yes	Yes	1	6	8
213	R:R:D57	R:R:Y53	5.75	No	Yes	1	4	1
214	R:R:K54	R:R:R58	6.19	No	Yes	0	4	3
215	R:R:C55	R:R:M59	3.24	No	Yes	0	9	5
216	R:R:C55	R:R:W76	11.75	No	Yes	0	9	8
217	R:R:C55	R:R:C81	7.28	No	No	0	9	9
218	R:R:M59	R:R:Y56	4.79	Yes	Yes	0	5	3
219	R:R:W76	R:R:Y56	4.82	Yes	Yes	1	8	3
220	R:R:Q61	R:R:R58	9.35	No	Yes	0	3	3
221	R:R:L62	R:R:R58	7.29	No	Yes	0	3	3
222	R:R:M59	R:R:R74	8.69	Yes	No	0	5	4
223	R:R:L62	R:R:P63	6.57	No	No	0	3	1
224	R:R:G67	R:R:Y65	4.35	No	Yes	0	2	3
225	R:R:Y65	R:R:Y71	23.83	Yes	No	1	3	3
226	R:R:D84	R:R:Y65	6.9	Yes	Yes	1	4	3
227	R:R:P86	R:R:Y65	5.56	No	Yes	1	2	3
228	R:R:E68	R:R:G69	3.27	No	No	0	1	1
229	R:R:G69	R:R:P70	4.06	No	No	0	1	1
230	R:R:N73	R:R:Y71	10.47	No	No	1	4	3
231	R:R:D84	R:R:Y71	3.45	Yes	No	1	4	3
232	R:R:C112	R:R:C72	7.28	No	No	1	9	9
233	R:R:C72	R:R:G116	3.92	No	No	0	9	9
234	R:R:C72	R:R:W118	15.67	No	Yes	1	9	9
235	R:R:D84	R:R:N73	4.04	Yes	No	1	4	4
236	R:R:D84	R:R:R74	15.48	Yes	No	0	4	4
237	R:R:T75	R:R:W118	4.85	No	Yes	0	5	9
238	R:R:G78	R:R:W76	7.04	No	Yes	0	5	8
239	R:R:D77	R:R:W82	8.93	No	Yes	1	9	9
240	R:R:D77	R:R:S129	7.36	No	Yes	1	9	7
241	R:R:D77	R:R:Y131	11.49	No	Yes	1	9	5
242	R:R:W79	R:R:Y98	4.82	Yes	Yes	1	6	4
243	R:R:F99	R:R:W79	6.01	Yes	Yes	1	5	6
244	R:R:F102	R:R:W79	5.01	Yes	Yes	1	4	6
245	R:R:W79	R:R:Y131	17.36	Yes	Yes	1	6	5
246	R:R:L80	R:R:W82	5.69	Yes	Yes	1	5	9
247	R:R:L80	R:R:Q93	15.97	Yes	No	1	5	6
248	R:R:L80	R:R:P96	9.85	Yes	Yes	1	5	9
249	R:R:L80	R:R:V108	4.47	Yes	Yes	1	5	7
250	R:R:L80	R:R:Y131	8.21	Yes	Yes	1	5	5
251	R:R:S91	R:R:W82	4.94	No	Yes	0	5	9
252	R:R:Q93	R:R:W82	12.05	No	Yes	1	6	9
253	R:R:V108	R:R:W82	4.9	Yes	Yes	1	7	9
254	R:R:K110	R:R:W82	17.4	Yes	Yes	1	8	9
255	R:R:S129	R:R:W82	4.94	Yes	Yes	1	7	9
256	R:R:P86	R:R:T85	3.5	No	Yes	1	2	7
257	R:R:T85	R:R:V89	3.17	Yes	No	1	7	5
258	R:R:S91	R:R:T85	3.2	No	Yes	0	5	7
259	R:R:C112	R:R:T85	5.07	No	Yes	1	9	7
260	R:R:T85	R:R:W118	6.06	Yes	Yes	1	7	9
261	R:R:P86	R:R:V89	7.07	No	No	1	2	5
262	R:R:G88	R:R:Y111	2.9	No	No	0	8	4
263	R:R:L90	R:R:Y92	4.69	No	No	4	4	4
264	R:R:L90	R:R:T109	8.84	No	No	4	4	5
265	R:R:L90	R:R:Y111	7.03	No	No	0	4	4
266	R:R:K107	R:R:Y92	8.36	No	No	0	3	4
267	R:R:T109	R:R:Y92	6.24	No	No	4	5	4
268	R:R:F94	R:R:K107	7.44	No	No	0	3	3
269	R:R:C95	R:R:P96	3.77	Yes	Yes	1	9	9
270	R:R:C95	R:R:F102	6.98	Yes	Yes	1	9	4
271	R:R:C95	R:R:V108	3.42	Yes	Yes	1	9	7
272	R:R:C134	R:R:C95	7.28	No	Yes	1	9	9
273	R:R:P96	R:R:Y98	12.52	Yes	Yes	1	9	4
274	R:R:F102	R:R:P96	5.78	Yes	Yes	1	4	9
275	R:R:P96	R:R:Y131	4.17	Yes	Yes	1	9	5
276	R:R:D97	R:R:P104	4.83	No	No	0	2	3
277	R:R:F99	R:R:Y98	9.28	Yes	Yes	1	5	4
278	R:R:F102	R:R:F99	12.86	Yes	Yes	1	4	5
279	R:R:F102	R:R:Y131	3.09	Yes	Yes	1	4	5
280	R:R:C134	R:R:F102	15.36	No	Yes	1	9	4
281	R:R:D103	R:R:P104	6.44	Yes	No	5	3	3
282	R:R:D103	R:R:S105	4.42	Yes	No	5	3	1
283	R:R:D103	R:R:E106	9.09	Yes	No	5	3	4
284	R:R:E106	R:R:S105	2.87	No	No	5	4	1
285	R:R:K107	R:R:M133	2.88	No	No	0	3	5
286	R:R:V108	R:R:Y131	13.88	Yes	Yes	1	7	5
287	R:R:N130	R:R:T109	5.85	Yes	No	4	8	5
288	R:R:K110	R:R:W118	22.05	Yes	Yes	1	8	9
289	R:R:K110	R:R:S129	13.77	Yes	Yes	1	8	7
290	R:R:D113	R:R:Y111	6.9	No	No	0	5	4
291	R:R:C112	R:R:W118	3.92	No	Yes	1	9	9
292	R:R:D113	R:R:F119	7.17	No	No	0	5	4
293	R:R:E114	R:R:K115	2.7	No	No	0	2	5
294	R:R:H121	R:R:P122	9.15	No	No	0	4	5
295	R:R:H121	R:R:W128	25.39	No	Yes	0	4	5
296	R:R:N130	R:R:W128	11.3	Yes	Yes	4	8	5
297	R:R:S129	R:R:Y131	5.09	Yes	Yes	1	7	5
298	R:R:N130	R:R:T132	8.77	Yes	No	4	8	6
299	R:R:C134	R:R:Y131	2.69	No	Yes	1	9	5
300	R:R:A136	R:R:F137	8.32	No	No	0	2	1
301	R:R:F137	R:R:K141	4.96	No	No	0	1	3
302	R:R:P139	R:R:T138	3.5	No	No	0	3	2
303	R:R:E140	R:R:K143	8.1	No	No	0	2	1
304	R:R:E140	R:R:N144	3.94	No	No	0	2	4
305	R:R:K141	R:R:K366	5.75	No	No	0	3	3
306	R:R:L142	R:R:Y146	8.21	No	Yes	0	2	2
307	R:R:K370	R:R:N144	8.39	No	No	6	4	4
308	R:R:N144	R:R:Y374	5.81	No	Yes	6	4	6
309	R:R:V147	R:R:Y374	6.31	No	Yes	0	4	6
310	R:R:D373	R:R:L148	5.43	No	Yes	0	5	5
311	R:R:H377	R:R:L148	16.71	Yes	Yes	6	7	5
312	R:R:Y149	R:R:Y150	8.94	Yes	No	0	5	4
313	R:R:L202	R:R:Y149	7.03	No	Yes	0	7	5
314	R:R:P207	R:R:Y149	2.78	No	Yes	0	3	5
315	R:R:I153	R:R:Y150	4.84	No	No	0	7	4
316	R:R:L151	R:R:S378	4.5	No	No	0	5	5
317	R:R:F382	R:R:L151	3.65	No	No	0	7	5
318	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
319	R:R:F382	R:R:G155	9.03	No	No	0	7	8
320	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
321	R:R:H156	R:R:I198	13.26	Yes	Yes	0	7	7
322	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
323	R:R:H156	R:R:H381	11.94	Yes	Yes	0	7	9
324	R:R:F385	R:R:L158	9.74	Yes	No	0	5	4
325	R:R:G384	R:R:S159	3.71	No	No	0	9	9
326	R:R:I160	R:R:S195	4.64	No	No	0	5	7
327	R:R:F161	R:R:I165	5.02	No	No	0	4	5
328	R:R:F385	R:R:T162	7.78	Yes	No	0	5	6
329	R:R:A388	R:R:T162	3.36	No	No	0	8	6
330	R:R:F393	R:R:T162	3.89	Yes	No	0	8	6
331	R:R:F188	R:R:L163	6.09	No	Yes	0	8	8
332	R:R:L163	R:R:Y191	5.86	Yes	Yes	0	8	8
333	R:R:I192	R:R:L163	2.85	No	Yes	0	7	8
334	R:R:A388	R:R:L163	3.15	No	Yes	0	8	8
335	R:R:I192	R:R:V164	3.07	No	No	0	7	4
336	R:R:F393	R:R:I165	3.77	Yes	No	0	8	5
337	R:R:A388	R:R:S166	3.42	No	No	0	8	9
338	R:R:C392	R:R:S166	6.89	No	No	12	9	9
339	R:R:F393	R:R:S166	7.93	Yes	No	12	8	9
340	R:R:K185	R:R:L167	2.82	No	No	0	6	6
341	R:R:I169	R:R:V402	3.07	No	No	0	8	5
342	R:R:F170	R:R:V181	11.8	Yes	Yes	0	8	9
343	R:R:F170	R:R:H184	5.66	Yes	Yes	0	8	9
344	R:R:F170	R:R:F188	6.43	Yes	No	0	8	8
345	R:R:C392	R:R:F170	4.19	No	Yes	0	9	8
346	R:R:K185	R:R:V171	3.04	No	No	0	6	4
347	R:R:F172	R:R:F409	4.29	No	No	0	2	3
348	R:R:F173	R:R:S175	3.96	Yes	No	8	7	8
349	R:R:F173	R:R:L176	6.09	Yes	Yes	8	7	9
350	R:R:F173	R:R:T401	5.19	Yes	Yes	8	7	7
351	R:R:F173	R:R:Q405	11.71	Yes	Yes	8	7	4
352	R:R:S175	R:R:T401	3.2	No	Yes	8	8	7
353	R:R:Q405	R:R:S175	4.33	Yes	No	8	4	8
354	R:R:E397	R:R:L176	6.63	No	Yes	0	9	9
355	R:R:L176	R:R:V398	7.45	Yes	No	0	9	9
356	R:R:L176	R:R:T401	8.84	Yes	Yes	8	9	7
357	R:R:G177	R:R:V181	3.68	No	Yes	0	7	9
358	R:R:C178	R:R:R180	5.57	No	No	0	8	9
359	R:R:C178	R:R:V181	3.42	No	Yes	0	8	9
360	R:R:Q179	R:R:Y243	6.76	No	Yes	0	7	8
361	R:R:K256	R:R:Q179	4.07	No	No	0	5	7
362	R:R:L259	R:R:Q179	7.99	Yes	No	0	5	7
363	R:R:H184	R:R:R180	7.9	Yes	No	0	9	9
364	R:R:E397	R:R:R180	3.49	No	No	0	9	9
365	R:R:K185	R:R:V181	4.55	No	Yes	0	6	9
366	R:R:L259	R:R:T182	2.95	Yes	No	0	5	5
367	R:R:L183	R:R:W236	3.42	Yes	Yes	2	8	9
368	R:R:E240	R:R:L183	5.3	Yes	Yes	0	9	8
369	R:R:L183	R:R:Y243	5.86	Yes	Yes	2	8	8
370	R:R:L183	R:R:L259	5.54	Yes	Yes	2	8	5
371	R:R:L183	R:R:Y262	4.69	Yes	Yes	2	8	7
372	R:R:E240	R:R:H184	6.15	Yes	Yes	0	9	9
373	R:R:H184	R:R:Y391	5.44	Yes	No	0	9	8
374	R:R:N186	R:R:W236	14.69	No	Yes	2	9	9
375	R:R:N186	R:R:Y263	9.3	No	No	2	9	5
376	R:R:N186	R:R:W267	9.04	No	Yes	2	9	9
377	R:R:M187	R:R:Y191	8.38	Yes	Yes	2	8	8
378	R:R:M187	R:R:N233	2.8	Yes	Yes	2	8	9
379	R:R:M187	R:R:M237	2.89	Yes	Yes	2	8	9
380	R:R:E240	R:R:M187	10.83	Yes	Yes	0	9	8
381	R:R:F188	R:R:V387	3.93	No	No	0	8	9
382	R:R:L189	R:R:L193	4.15	No	No	0	3	6
383	R:R:L189	R:R:W267	6.83	No	Yes	0	3	9
384	R:R:N233	R:R:T190	8.77	Yes	No	2	9	9
385	R:R:T190	R:R:W236	6.06	No	Yes	2	9	9
386	R:R:T190	R:R:W267	4.85	No	Yes	2	9	9
387	R:R:N233	R:R:Y191	16.28	Yes	Yes	2	9	8
388	R:R:M237	R:R:Y191	5.99	Yes	Yes	2	9	8
389	R:R:Q383	R:R:Y191	12.4	Yes	Yes	2	9	8
390	R:R:G384	R:R:Y191	7.24	No	Yes	0	9	8
391	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
392	R:R:I192	R:R:M196	2.92	No	No	0	7	4
393	R:R:L193	R:R:M229	7.07	No	No	0	6	4
394	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
395	R:R:M230	R:R:N194	2.8	Yes	No	0	6	8
396	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
397	R:R:H226	R:R:I197	5.3	Yes	No	0	6	5
398	R:R:I197	R:R:M229	2.92	No	No	0	5	4
399	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
400	R:R:H226	R:R:I198	6.63	Yes	Yes	0	6	7
401	R:R:I200	R:R:L222	2.85	No	No	0	6	6
402	R:R:H201	R:R:V205	8.3	Yes	No	0	6	7
403	R:R:H201	R:R:V206	2.77	Yes	No	0	6	3
404	R:R:H201	R:R:L291	3.86	Yes	Yes	0	6	6
405	R:R:E204	R:R:V203	4.28	No	No	0	4	3
406	R:R:P207	R:R:V206	5.3	No	No	0	3	3
407	R:R:E210	R:R:N208	3.94	No	No	0	3	3
408	R:R:L211	R:R:N208	5.49	No	No	0	1	3
409	R:R:L211	R:R:R214	8.5	No	No	0	1	4
410	R:R:L211	R:R:P216	6.57	No	No	0	1	4
411	R:R:C289	R:R:V212	3.42	Yes	Yes	7	9	3
412	R:R:L291	R:R:V212	2.98	Yes	Yes	7	6	3
413	R:R:D215	R:R:K220	11.06	No	No	0	6	7
414	R:R:D215	R:R:N288	13.46	No	No	0	6	4
415	R:R:C289	R:R:D215	3.11	Yes	No	0	9	6
416	R:R:P216	R:R:S218	3.56	No	No	0	4	3
417	R:R:C219	R:R:P216	5.65	No	No	0	9	4
418	R:R:I221	R:R:V217	3.07	No	No	0	4	3
419	R:R:C219	R:R:C289	7.28	No	Yes	0	9	9
420	R:R:K220	R:R:N286	9.79	No	No	3	7	7
421	R:R:K220	R:R:W290	20.89	No	Yes	3	7	9
422	R:R:H223	R:R:Q227	12.36	No	Yes	0	5	7
423	R:R:H223	R:R:W290	11.64	No	Yes	0	5	9
424	R:R:F224	R:R:T274	6.49	No	No	0	5	6
425	R:R:A278	R:R:F224	2.77	No	No	0	6	5
426	R:R:H226	R:R:Q227	6.18	Yes	Yes	2	6	7
427	R:R:I301	R:R:Q227	6.86	No	Yes	0	7	7
428	R:R:C232	R:R:Y228	9.41	No	Yes	2	8	8
429	R:R:P270	R:R:Y228	2.78	Yes	Yes	2	9	8
430	R:R:L271	R:R:Y228	7.03	No	Yes	0	4	8
431	R:R:T274	R:R:Y228	4.99	No	Yes	0	6	8
432	R:R:M230	R:R:Y234	5.99	Yes	Yes	2	6	7
433	R:R:H302	R:R:M230	6.57	Yes	Yes	2	6	6
434	R:R:C232	R:R:W267	5.22	No	Yes	2	8	9
435	R:R:C232	R:R:P270	5.65	No	Yes	2	8	9
436	R:R:M237	R:R:N233	4.21	Yes	Yes	2	9	9
437	R:R:M237	R:R:Y234	4.79	Yes	Yes	2	9	7
438	R:R:V305	R:R:Y234	10.09	No	Yes	2	7	7
439	R:R:F356	R:R:Y234	13.41	Yes	Yes	2	7	7
440	R:R:F235	R:R:L265	3.65	Yes	Yes	0	5	7
441	R:R:F235	R:R:F269	5.36	Yes	Yes	2	5	3
442	R:R:A308	R:R:F235	2.77	No	Yes	0	7	5
443	R:R:C239	R:R:W236	7.84	No	Yes	0	7	9
444	R:R:W236	R:R:Y263	3.86	Yes	No	2	9	5
445	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
446	R:R:W236	R:R:W267	17.81	Yes	Yes	2	9	9
447	R:R:L309	R:R:M237	2.83	No	Yes	0	7	9
448	R:R:M237	R:R:Q383	8.16	Yes	Yes	2	9	9
449	R:R:I242	R:R:L238	5.71	Yes	Yes	0	7	8
450	R:R:L238	R:R:L265	2.77	Yes	Yes	0	8	7
451	R:R:A308	R:R:L238	4.73	No	Yes	0	7	8
452	R:R:L238	R:R:V311	2.98	Yes	No	0	8	6
453	R:R:L238	R:R:N312	4.12	Yes	No	0	8	9
454	R:R:C239	R:R:Y262	4.03	No	Yes	0	7	7
455	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
456	R:R:E240	R:R:L351	9.28	Yes	No	0	9	9
457	R:R:G241	R:R:N312	3.39	No	No	0	8	9
458	R:R:I242	R:R:Y262	4.84	Yes	Yes	2	7	7
459	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
460	R:R:L247	R:R:Y243	8.21	No	Yes	0	8	8
461	R:R:Q257	R:R:Y243	7.89	Yes	Yes	2	5	8
462	R:R:Y243	R:R:Y262	4.96	Yes	Yes	2	8	7
463	R:R:I248	R:R:L244	2.85	Yes	No	0	7	9
464	R:R:I319	R:R:L244	4.28	No	No	0	9	9
465	R:R:L244	R:R:L348	2.77	No	No	0	9	9
466	R:R:H245	R:R:V249	11.07	Yes	No	0	8	6
467	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
468	R:R:F315	R:R:H245	21.5	No	Yes	0	8	8
469	R:R:H245	R:R:N318	6.38	Yes	No	0	8	8
470	R:R:Q257	R:R:T246	8.5	Yes	No	0	5	7
471	R:R:I248	R:R:L247	2.85	Yes	No	0	7	8
472	R:R:I248	R:R:V249	3.07	Yes	No	0	7	6
473	R:R:I248	R:R:V322	3.07	Yes	No	0	7	8
474	R:R:Q257	R:R:Y262	5.64	Yes	Yes	2	5	7
475	R:R:R258	R:R:R260	13.86	No	No	2	5	3
476	R:R:R258	R:R:W261	7	No	Yes	2	5	2
477	R:R:L259	R:R:Y262	3.52	Yes	Yes	2	5	7
478	R:R:L259	R:R:Y263	5.86	Yes	No	2	5	5
479	R:R:R260	R:R:W261	5	No	Yes	2	3	2
480	R:R:F269	R:R:P270	4.33	Yes	Yes	2	3	9
481	R:R:F269	R:R:V272	3.93	Yes	No	0	3	4
482	R:R:P273	R:R:V272	3.53	No	No	0	6	4
483	R:R:I276	R:R:I300	4.42	No	Yes	0	5	8
484	R:R:H277	R:R:R281	10.16	No	Yes	0	7	7
485	R:R:H277	R:R:I300	2.65	No	Yes	0	7	8
486	R:R:H277	R:R:I301	11.93	No	No	0	7	7
487	R:R:L297	R:R:T280	8.84	Yes	No	3	4	4
488	R:R:I300	R:R:T280	3.04	Yes	No	3	8	4
489	R:R:F285	R:R:R281	5.34	Yes	Yes	3	6	7
490	R:R:D287	R:R:R281	8.34	Yes	Yes	3	3	7
491	R:R:R281	R:R:W290	15.99	Yes	Yes	3	7	9
492	R:R:R281	R:R:T295	6.47	Yes	Yes	3	7	4
493	R:R:V283	R:R:Y284	7.57	No	No	0	3	2
494	R:R:D287	R:R:F285	7.17	Yes	Yes	3	3	6
495	R:R:F285	R:R:S292	7.93	Yes	No	3	6	4
496	R:R:F285	R:R:T295	15.56	Yes	Yes	3	6	4
497	R:R:N286	R:R:W290	6.78	No	Yes	3	7	9
498	R:R:D287	R:R:W290	3.35	Yes	Yes	3	3	9
499	R:R:D287	R:R:S292	7.36	Yes	No	3	3	4
500	R:R:C289	R:R:L291	3.17	Yes	Yes	7	9	6
501	R:R:E294	R:R:S292	2.87	No	No	0	3	4
502	R:R:L298	R:R:V293	2.98	No	No	0	6	6
503	R:R:L297	R:R:T295	5.9	Yes	Yes	3	4	4
504	R:R:H296	R:R:Y299	3.27	No	Yes	0	2	7
505	R:R:I300	R:R:L297	2.85	Yes	Yes	3	8	4
506	R:R:H302	R:R:L298	3.86	Yes	No	2	6	6
507	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
508	R:R:F356	R:R:L309	4.87	Yes	No	0	7	7
509	R:R:F314	R:R:V310	3.93	No	No	0	5	4
510	R:R:F315	R:R:V311	5.24	No	No	0	8	6
511	R:R:L352	R:R:N312	10.98	No	No	0	9	9
512	R:R:F313	R:R:L317	9.74	Yes	No	0	6	5
513	R:R:F313	R:R:I354	5.02	Yes	Yes	0	6	6
514	R:R:F313	R:R:V357	10.49	Yes	No	0	6	7
515	R:R:L316	R:R:V320	2.98	Yes	No	13	9	7
516	R:R:L316	R:R:T345	2.95	Yes	No	13	9	9
517	R:R:L316	R:R:L348	4.15	Yes	No	0	9	9
518	R:R:I354	R:R:L316	7.14	Yes	Yes	0	6	9
519	R:R:N318	R:R:R321	7.23	No	No	0	8	8
520	R:R:T345	R:R:V320	4.76	No	No	13	9	7
521	R:R:K326	R:R:V322	3.04	No	No	0	9	8
522	R:R:L323	R:R:M327	2.83	No	Yes	0	9	7
523	R:R:M327	R:R:V324	3.04	Yes	No	0	7	5
524	R:R:E329	R:R:T325	5.64	No	No	0	6	7
525	R:R:E329	R:R:K326	2.7	No	No	0	6	9
526	R:R:E332	R:R:M327	12.18	No	Yes	9	5	7
527	R:R:M327	R:R:M337	5.78	Yes	Yes	9	7	7
528	R:R:K340	R:R:M327	4.32	No	Yes	0	8	7
529	R:R:E334	R:R:R328	8.14	No	No	9	6	6
530	R:R:M337	R:R:R328	8.69	Yes	No	9	7	6
531	R:R:E332	R:R:H336	13.54	No	No	0	5	6
532	R:R:E332	R:R:M337	5.41	No	Yes	9	5	7
533	R:R:E334	R:R:M337	2.71	No	Yes	9	6	7
534	R:R:E334	R:R:Y338	7.86	No	No	0	6	7
535	R:R:H336	R:R:K340	6.55	No	No	0	6	8
536	R:R:I347	R:R:I390	2.94	No	No	0	8	8
537	R:R:P350	R:R:V349	5.3	No	No	0	9	8
538	R:R:I354	R:R:V349	7.68	Yes	No	0	6	8
539	R:R:F386	R:R:P350	2.89	No	No	0	5	9
540	R:R:I390	R:R:P350	5.08	No	No	0	8	9
541	R:R:L351	R:R:L352	4.15	No	No	0	9	9
542	R:R:L351	R:R:Y391	22.27	No	No	0	9	8
543	R:R:I354	R:R:L352	2.85	Yes	No	0	6	9
544	R:R:F356	R:R:G353	3.01	Yes	No	0	7	9
545	R:R:F356	R:R:Q355	12.88	Yes	Yes	2	7	8
546	R:R:M376	R:R:Q355	2.72	Yes	Yes	2	7	8
547	R:R:L379	R:R:Q355	7.99	No	Yes	0	5	8
548	R:R:Q355	R:R:Q383	11.52	Yes	Yes	2	8	9
549	R:R:F356	R:R:I380	3.77	Yes	No	0	7	6
550	R:R:F356	R:R:Q383	4.68	Yes	Yes	2	7	9
551	R:R:F359	R:R:V358	5.24	Yes	No	0	6	5
552	R:R:F359	R:R:Y372	4.13	Yes	Yes	2	6	7
553	R:R:F359	R:R:M376	6.22	Yes	Yes	2	6	7
554	R:R:P363	R:R:R362	2.88	No	Yes	2	7	4
555	R:R:G369	R:R:R362	6	No	Yes	0	4	4
556	R:R:R362	R:R:Y372	7.2	Yes	Yes	2	4	7
557	R:R:D373	R:R:R362	11.91	No	Yes	0	5	4
558	R:R:L368	R:R:P363	3.28	No	No	0	3	7
559	R:R:P363	R:R:Y372	8.34	No	Yes	2	7	7
560	R:R:L368	R:R:N365	10.98	No	No	0	3	4
561	R:R:I371	R:R:M367	2.92	No	No	0	5	4
562	R:R:K370	R:R:Y374	4.78	No	Yes	6	4	6
563	R:R:M376	R:R:Y372	11.97	Yes	Yes	2	7	7
564	R:R:I380	R:R:M376	2.92	No	Yes	0	6	7
565	R:R:H377	R:R:H381	10.75	Yes	Yes	0	7	9
566	R:R:H381	R:R:I380	3.98	Yes	No	0	9	6
567	R:R:F382	R:R:F386	4.29	No	No	0	7	5
568	R:R:F385	R:R:F386	5.36	Yes	No	0	5	5
569	R:R:F385	R:R:T389	6.49	Yes	No	0	5	5
570	R:R:I390	R:R:Y391	8.46	No	No	0	8	8
571	R:R:C392	R:R:F393	5.59	No	Yes	12	9	8
572	R:R:N395	R:R:V398	8.87	No	No	0	9	9
573	R:R:N396	R:R:T400	2.92	No	No	0	6	4
574	R:R:Q405	R:R:T401	4.25	Yes	Yes	8	4	7
575	R:R:F409	R:R:W406	3.01	No	No	0	3	6
576	L:L:V32	R:R:F102	2.62	No	Yes	0	0	4
577	R:R:F173	R:R:V402	2.62	Yes	No	0	7	5
578	E:E:A77	E:E:W84	2.59	No	Yes	0	7	9
579	R:R:F224	R:R:T275	2.59	No	No	0	5	3
580	R:R:R404	R:R:T400	2.59	No	No	0	7	4
581	R:R:H201	R:R:L222	2.57	Yes	No	0	6	6
582	L:L:S20	R:R:Y146	2.54	No	Yes	0	0	2
583	R:R:F225	R:R:I221	2.51	No	No	0	5	4
584	E:E:T94	R:R:Y56	2.5	No	Yes	0	7	3
585	L:L:F15	R:R:K141	2.48	Yes	No	0	0	3
586	E:E:V137	R:R:W261	2.45	Yes	Yes	2	9	2
587	E:E:F62	E:E:L59	2.44	No	No	0	8	7
588	E:E:L39	E:E:R36	2.43	No	No	0	1	3
589	R:R:L62	R:R:R74	2.43	No	No	0	3	4
590	E:E:M47	E:E:Y65	2.39	No	No	0	4	5
591	R:R:L148	R:R:Y374	2.34	Yes	Yes	6	5	6
592	R:R:Q405	R:R:R404	2.34	Yes	No	0	4	7
593	E:E:E76	E:E:R36	2.33	Yes	No	0	6	3
594	R:R:E294	R:R:F94	2.33	No	No	0	3	3
595	R:R:F313	R:R:F314	2.14	Yes	No	0	6	5
596	E:E:R108	R:R:R58	2.13	No	Yes	0	4	3
597	L:L:Y37	R:R:R126	2.06	Yes	No	0	0	4
598	R:R:G116	R:R:P70	2.03	No	No	0	9	1
599	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
600	E:E:C28	E:E:G81	1.96	No	No	0	9	4
601	L:L:P28	L:L:P29	1.95	No	No	0	0	0
602	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
603	L:L:G24	L:L:S20	1.86	No	No	0	0	0
604	R:R:G44	R:R:V43	1.84	No	No	0	4	2
605	L:L:G33	L:L:T36	1.82	No	Yes	0	0	0
606	E:E:C28	E:E:V80	1.71	No	No	1	9	5
607	E:E:C82	E:E:V80	1.71	Yes	No	1	9	5
608	R:R:A333	R:R:S335	1.71	No	No	0	5	6
609	E:E:V127	R:R:A307	1.7	No	No	0	7	3
610	E:E:V131	R:R:A307	1.7	No	No	0	6	3
611	R:R:A251	R:R:V250	1.7	No	No	0	6	5
612	R:R:A341	R:R:V320	1.7	No	No	0	9	7
613	R:R:A341	R:R:V324	1.7	No	No	0	9	5
614	E:E:I125	E:E:P121	1.69	No	No	0	5	5
615	R:R:C394	R:R:T389	1.69	No	No	0	5	5
616	E:E:L37	E:E:P38	1.64	No	No	0	8	5
617	L:L:L27	L:L:P28	1.64	No	No	0	0	0
618	L:L:P29	R:R:N135	1.63	No	No	0	0	3
619	E:E:A43	E:E:M47	1.61	No	No	0	2	4
620	L:L:A5	R:R:M306	1.61	No	No	0	0	4
621	L:L:A5	R:R:M376	1.61	No	Yes	0	0	7
622	E:E:V124	E:E:V128	1.6	No	No	0	4	4
623	R:R:A344	R:R:L323	1.58	No	No	0	9	9
624	E:E:A77	E:E:N78	1.56	No	No	0	7	1
625	R:R:I199	R:R:S157	1.55	No	No	0	7	7
626	E:E:I120	E:E:V124	1.54	No	No	0	5	4
627	E:E:I125	E:E:V124	1.54	No	No	0	5	4
628	R:R:I153	R:R:V154	1.54	No	No	0	7	6
629	R:R:I199	R:R:V203	1.54	No	No	0	7	3
630	R:R:I371	R:R:V375	1.54	No	No	0	5	4
631	E:E:K142	E:E:S141	1.53	No	No	0	8	9
632	E:E:C40	E:E:E76	1.52	Yes	Yes	1	9	6
633	E:E:C72	E:E:E76	1.52	No	Yes	1	9	6
634	R:R:M346	R:R:V342	1.52	No	No	0	8	8
635	R:R:M346	R:R:T345	1.51	No	No	0	8	9
636	R:R:K110	R:R:T127	1.5	Yes	No	0	8	4
637	R:R:L379	R:R:V375	1.49	No	No	0	5	4
638	E:E:N29	E:E:V80	1.48	Yes	No	1	8	5
639	R:R:D113	R:R:V117	1.46	No	No	0	5	5
640	R:R:A333	R:R:H336	1.46	No	No	0	5	6
641	R:R:D103	R:R:T138	1.45	Yes	No	0	3	2
642	R:R:I347	R:R:K343	1.45	No	No	0	8	8
643	E:E:S102	R:R:Q60	1.44	No	No	0	7	3
644	R:R:F99	R:R:P100	1.44	Yes	No	0	5	4
645	R:R:F359	R:R:P360	1.44	Yes	No	0	6	5
646	E:E:E76	E:E:V79	1.43	Yes	No	0	6	1
647	E:E:T105	R:R:Q61	1.42	No	No	0	8	3
648	R:R:K120	R:R:N125	1.4	No	No	0	1	7
649	E:E:D46	E:E:M47	1.39	No	No	0	1	4
650	R:R:K403	R:R:Q399	1.36	No	No	0	6	7
651	L:L:N21	R:R:E210	1.31	No	No	0	0	3
652	R:R:R45	R:R:V42	1.31	No	No	0	7	1
653	R:R:A282	R:R:W290	1.3	No	Yes	0	3	9
654	E:E:V64	E:E:Y65	1.26	No	No	0	4	5
655	R:R:F225	R:R:I197	1.26	No	No	0	5	5
656	R:R:D83	R:R:R58	1.19	No	Yes	0	5	3
657	E:E:N103	E:E:W56	1.13	No	Yes	0	8	7
658	H:H:?202	R:R:R45	1.09	No	No	0	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:N29	10.5575	4	1	8
2	E:E:M33	3.63	4	1	8
3	E:E:C40	3.7425	4	1	9
4	E:E:F44	6.736	5	1	9
5	E:E:M48	8.6775	4	1	9
6	E:E:W56	7.9875	4	0	7
7	E:E:Y66	4.948	5	1	9
8	E:E:F69	6.15286	7	1	8
9	E:E:E76	1.7	4	1	6
10	E:E:C82	4.2375	4	1	9
11	E:E:W84	8.44	7	1	9
12	E:E:N86	3.772	5	1	9
13	E:E:F92	5.775	4	1	8
14	E:E:I93	7.125	4	1	9
15	E:E:H97	9.974	5	1	9
16	E:E:F100	6.538	5	1	8
17	E:E:F101	8.19857	7	1	9
18	E:E:D113	5.206	5	3	9
19	E:E:P114	8.092	5	3	9
20	E:E:V137	4.47	4	2	9
21	L:L:K1	5.8675	4	0	0
22	L:L:C2	5.365	4	2	0
23	L:L:T4	3.32	4	2	0
24	L:L:T6	6.02167	6	2	0
25	L:L:Q10	4.122	5	2	0
26	L:L:R11	3.67	4	2	0
27	L:L:F15	4.462	5	5	0
28	L:L:H18	7.346	5	7	0
29	L:L:K19	4.785	4	5	0
30	L:L:T36	4.1075	4	11	0
31	L:L:Y37	5.28429	7	1	0
32	L:L:?38	6.82	4	0	0
33	R:R:Q52	11.6575	4	1	6
34	R:R:Y53	8.664	5	1	1
35	R:R:Y56	6.24	7	1	3
36	R:R:R58	5.23	5	0	3
37	R:R:M59	5.54	4	0	5
38	R:R:Y65	10.16	4	1	3
39	R:R:W76	9.664	5	1	8
40	R:R:W79	8.59333	6	1	6
41	R:R:L80	8.838	5	1	5
42	R:R:W82	8.40714	7	1	9
43	R:R:D84	7.4675	4	1	4
44	R:R:T85	4.2	5	1	7
45	R:R:C95	5.3625	4	1	9
46	R:R:P96	7.218	5	1	9
47	R:R:Y98	8.014	5	1	4
48	R:R:F99	6.956	5	1	5
49	R:R:F102	6.94875	8	1	4
50	R:R:D103	5.48333	6	5	3
51	R:R:V108	6.6675	4	1	7
52	R:R:K110	13.68	4	1	8
53	R:R:W118	10.51	5	1	9
54	R:R:W128	13.78	4	4	5
55	R:R:S129	7.79	4	1	7
56	R:R:N130	13.8725	4	4	8
57	R:R:Y131	7.97556	9	1	5
58	R:R:Y146	10.155	4	0	2
59	R:R:L148	6.8125	4	6	5
60	R:R:Y149	5.5675	4	0	5
61	R:R:H156	9.7525	4	0	7
62	R:R:L163	4.4875	4	0	8
63	R:R:F170	7.02	4	0	8
64	R:R:F173	5.914	5	8	7
65	R:R:L176	7.2525	4	8	9
66	R:R:V181	5.8625	4	0	9
67	R:R:L183	4.962	5	2	8
68	R:R:H184	6.2875	4	0	9
69	R:R:M187	6.225	4	2	8
70	R:R:Y191	8.92286	7	2	8
71	R:R:I198	6.288	5	0	7
72	R:R:H201	4.086	5	0	6
73	R:R:V212	3.84	4	7	3
74	R:R:H226	5.455	4	2	6
75	R:R:Q227	7.95	4	2	7
76	R:R:Y228	6.0525	4	2	8
77	R:R:M230	4.52	4	2	6
78	R:R:N233	7.23	5	2	9
79	R:R:Y234	8.604	5	2	7
80	R:R:F235	4.89	4	2	5
81	R:R:W236	8.87429	7	2	9
82	R:R:M237	4.81167	6	2	9
83	R:R:L238	4.17333	6	0	8
84	R:R:E240	7.89	4	0	9
85	R:R:I242	4.706	5	2	7
86	R:R:Y243	6.736	5	2	8
87	R:R:H245	10.43	4	0	8
88	R:R:I248	2.96	4	0	7
89	R:R:Q257	7.6725	4	2	5
90	R:R:L259	5.172	5	2	5
91	R:R:W261	5.802	5	2	2
92	R:R:Y262	4.885	8	2	7
93	R:R:L265	3.68	5	0	7
94	R:R:W267	8.75	5	2	9
95	R:R:F269	4.77	6	2	3
96	R:R:P270	3.332	5	2	9
97	R:R:R281	9.26	5	3	7
98	R:R:F285	8.21833	6	3	6
99	R:R:D287	5.786	5	3	3
100	R:R:C289	4.245	4	7	9
101	R:R:W290	9.99167	6	3	9
102	R:R:L291	3.2475	4	7	6
103	R:R:T295	9.15	4	3	4
104	R:R:L297	5.374	5	3	4
105	R:R:Y299	4.6775	4	0	7
106	R:R:I300	3.734	5	3	8
107	R:R:H302	6.37167	6	2	6
108	R:R:P304	4.185	4	0	9
109	R:R:F313	6.8475	4	0	6
110	R:R:L316	4.305	4	13	9
111	R:R:M327	5.63	5	9	7
112	R:R:M337	5.6475	4	9	7
113	R:R:I354	5.6725	4	0	6
114	R:R:Q355	8.7775	4	2	8
115	R:R:F356	6.64429	7	2	7
116	R:R:F359	4.2575	4	2	6
117	R:R:R362	6.00167	6	2	4
118	R:R:Y372	7.91	4	2	7
119	R:R:Y374	4.81	4	6	6
120	R:R:M376	5.088	5	2	7
121	R:R:H377	9.2475	4	6	7
122	R:R:H381	7.346	5	0	9
123	R:R:Q383	9.19	4	2	9
124	R:R:F385	7.3425	4	0	5
125	R:R:F393	5.295	4	12	8
126	R:R:T401	5.37	4	8	7
127	R:R:Q405	5.6575	4	8	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:I93	E:E:W84	26.6453	3.52	Yes	Yes	1	9	9
2	E:E:F69	E:E:I93	10.6354	3.77	Yes	Yes	1	8	9
3	E:E:I93	R:R:Y56	14.1358	12.09	Yes	Yes	1	9	3
4	E:E:Y66	R:R:Y56	12.6466	3.97	Yes	Yes	1	9	3
5	E:E:W84	R:R:W76	21.6836	2.81	Yes	Yes	1	9	8
6	R:R:W76	R:R:Y56	27.4638	4.82	Yes	Yes	1	8	3
7	E:E:H97	R:R:Y56	14.1991	7.62	Yes	Yes	1	9	3
8	E:E:F101	E:E:F62	20.4825	9.65	Yes	No	0	9	8
9	E:E:F62	E:E:Y65	16.3905	4.13	No	No	0	8	5
10	E:E:W84	L:L:Y37	53.1313	3.86	Yes	Yes	1	9	0
11	R:R:M59	R:R:Y56	13.9163	4.79	Yes	Yes	0	5	3
12	L:L:?38	L:L:Y37	75.3003	2.9	Yes	Yes	0	0	0
13	L:L:?38	R:R:W128	97.0403	11.28	Yes	Yes	0	0	5
14	R:R:N130	R:R:W128	97.6604	11.3	Yes	Yes	4	8	5
15	R:R:N130	R:R:T109	98.2536	5.85	Yes	No	4	8	5
16	R:R:T109	R:R:Y92	97.7844	6.24	No	No	4	5	4
17	R:R:K107	R:R:Y92	99.533	8.36	No	No	0	3	4
18	R:R:F94	R:R:K107	99.8472	7.44	No	No	0	3	3
19	R:R:E294	R:R:F94	100	2.33	No	No	0	3	3
20	L:L:K1	R:R:E294	92.1954	12.15	Yes	No	0	0	3
21	L:L:K1	R:R:V293	77.7377	4.55	Yes	No	0	0	6
22	R:R:L298	R:R:V293	77.8752	2.98	No	No	0	6	6
23	R:R:H302	R:R:L298	77.226	3.86	Yes	No	2	6	6
24	R:R:H302	R:R:M230	52.3744	6.57	Yes	Yes	2	6	6
25	R:R:M230	R:R:N194	36.94	2.8	Yes	No	0	6	8
26	R:R:N194	R:R:N233	46.7572	4.09	No	Yes	0	8	9
27	R:R:N233	R:R:T190	23.605	8.77	Yes	No	2	9	9
28	R:R:T190	R:R:W236	17.5214	6.06	No	Yes	2	9	9
29	L:L:T6	R:R:H302	24.103	9.58	Yes	Yes	2	0	6
30	L:L:T6	R:R:Y234	19.9822	8.74	Yes	Yes	2	0	7
31	R:R:M237	R:R:Y234	39.9453	4.79	Yes	Yes	2	9	7
32	R:R:M187	R:R:M237	30.4631	2.89	Yes	Yes	2	8	9
33	R:R:E240	R:R:M187	49.7545	10.83	Yes	Yes	0	9	8
34	R:R:E240	R:R:L183	20.3979	5.3	Yes	Yes	0	9	8
35	R:R:L183	R:R:Y262	14.8126	4.69	Yes	Yes	2	8	7
36	R:R:M230	R:R:Y234	19.7732	5.99	Yes	Yes	2	6	7
37	R:R:M187	R:R:N233	18.223	2.8	Yes	Yes	2	8	9
38	R:R:M59	R:R:R74	19.0007	8.69	Yes	No	0	5	4
39	L:L:K1	L:L:R11	11.4213	3.71	Yes	Yes	0	0	0
40	R:R:I198	R:R:N194	10.7198	5.66	Yes	No	0	7	8
41	L:L:Y37	R:R:G78	21.4085	7.24	Yes	No	0	0	5
42	R:R:G78	R:R:W76	21.1564	7.04	No	Yes	0	5	8
43	L:L:?38	R:R:Y131	22.4726	5.8	Yes	Yes	0	0	5
44	R:R:L62	R:R:R74	11.6605	2.43	No	No	0	3	4
45	R:R:Q383	R:R:Y191	12.0645	12.4	Yes	Yes	2	9	8
46	R:R:L163	R:R:Y191	20.1641	5.86	Yes	Yes	0	8	8
47	R:R:A388	R:R:L163	12.359	3.15	No	Yes	0	8	8
48	R:R:M237	R:R:Y191	10.4535	5.99	Yes	Yes	2	9	8
49	R:R:E240	R:R:H184	15.9173	6.15	Yes	Yes	0	9	9
50	R:R:H184	R:R:R180	10.0969	7.9	Yes	No	0	9	9
51	R:R:E240	R:R:L351	17.7529	9.28	Yes	No	0	9	9
52	R:R:L351	R:R:L352	15.3754	4.15	No	No	0	9	9
53	R:R:I354	R:R:L352	14.8887	2.85	Yes	No	0	6	9
54	R:R:I354	R:R:L316	11.4544	7.14	Yes	Yes	0	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:E74	E:E:W84	23.99	1	No	Yes	5	9	1	1
E:E:E74	L:L:Y37	5.61	1	No	Yes	5	0	1	0
E:E:Y83	R:R:R126	21.61	0	No	No	6	4	2	1
E:E:P85	E:E:W84	18.92	1	No	Yes	9	9	1	1
E:E:N86	E:E:W84	3.39	1	Yes	Yes	9	9	2	1
E:E:I93	E:E:W84	3.52	1	Yes	Yes	9	9	2	1
E:E:W84	L:L:Y37	3.86	1	Yes	Yes	9	0	1	0
E:E:W84	R:R:W76	2.81	1	Yes	Yes	9	8	1	2
E:E:P85	L:L:Y37	2.78	1	No	Yes	9	0	1	0
E:E:I123	R:R:Y299	3.63	0	No	Yes	9	7	2	1
H:H:?2	R:R:W128	7.15	4	No	Yes	0	5	2	1
H:H:?2	R:R:N130	29.57	4	No	Yes	0	8	2	2
L:L:K1	R:R:S105	3.06	0	Yes	No	0	1	0	1
L:L:K1	R:R:V293	4.55	0	Yes	No	0	6	0	1
L:L:K1	R:R:E294	12.15	0	Yes	No	0	3	0	1
L:L:C2	R:R:L298	3.17	2	Yes	No	0	6	0	1
L:L:C2	R:R:Y299	8.06	2	Yes	Yes	0	7	0	1
L:L:C2	R:R:H302	2.95	2	Yes	Yes	0	6	0	1
L:L:N3	R:R:W361	18.08	2	No	No	0	4	0	1
L:L:N3	R:R:R362	4.82	2	No	Yes	0	4	0	1
L:L:T4	R:R:Y299	3.75	2	Yes	Yes	0	7	0	1
L:L:T4	R:R:M306	3.01	2	Yes	No	0	4	0	1
L:L:T6	R:R:Y234	8.74	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	9.58	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	4.76	2	Yes	No	0	7	0	1
L:L:T6	R:R:M306	6.02	2	Yes	No	0	4	0	1
L:L:T6	R:R:F356	3.89	2	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	10.32	2	No	Yes	0	6	0	1
L:L:A8	R:R:H377	4.39	0	No	Yes	0	7	0	1
L:L:T9	R:R:I198	3.04	0	No	Yes	0	7	0	1
L:L:T9	R:R:H381	2.74	0	No	Yes	0	9	0	1
L:L:Q10	R:R:H226	3.71	2	Yes	Yes	0	6	0	1
L:L:Q10	R:R:Q227	6.4	2	Yes	Yes	0	7	0	1
L:L:Q10	R:R:M230	2.72	2	Yes	Yes	0	6	0	1
L:L:Q10	R:R:H302	4.95	2	Yes	Yes	0	6	0	1
L:L:R11	R:R:R362	3.2	2	Yes	Yes	0	4	0	1
L:L:L12	R:R:L148	2.77	6	No	Yes	0	5	0	1
L:L:L12	R:R:H377	5.14	6	No	Yes	0	7	0	1
L:L:A13	R:R:H201	2.93	0	No	Yes	0	6	0	1
L:L:N14	R:R:V293	5.91	0	No	No	0	6	0	1
L:L:F15	R:R:D103	5.97	5	Yes	Yes	0	3	0	1
L:L:F15	R:R:L142	3.65	5	Yes	No	0	2	0	1
L:L:F15	R:R:A145	2.77	5	Yes	No	0	4	0	1
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
L:L:L16	R:R:Y146	8.21	0	No	Yes	0	2	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:V17	R:R:V212	4.81	7	No	Yes	0	3	0	1
L:L:V17	R:R:L291	2.98	7	No	Yes	0	6	0	1
L:L:H18	R:R:D97	5.04	7	Yes	No	0	2	0	1
L:L:H18	R:R:G209	3.18	7	Yes	No	0	3	0	1
L:L:H18	R:R:V212	4.15	7	Yes	Yes	0	3	0	1
L:L:H18	R:R:R213	14.67	7	Yes	No	0	2	0	1
L:L:K19	R:R:D103	5.53	5	Yes	Yes	0	3	0	1
L:L:K19	R:R:P104	3.35	5	Yes	No	0	3	0	1
L:L:K19	R:R:L142	2.82	5	Yes	No	0	2	0	1
L:L:F23	R:R:Y146	21.66	0	No	Yes	0	2	0	1
L:L:F23	R:R:Y150	8.25	0	No	No	0	4	0	1
L:L:T30	R:R:F99	5.19	1	No	Yes	0	5	0	1
L:L:T30	R:R:D101	4.34	1	No	No	0	4	0	1
L:L:T30	R:R:F102	3.89	1	No	Yes	0	4	0	1
L:L:V32	R:R:N135	7.39	0	No	No	0	3	0	1
L:L:S34	R:R:H121	13.95	0	No	No	0	4	0	1
L:L:S34	R:R:E123	7.19	0	No	No	0	4	0	1
L:L:Y37	R:R:G78	7.24	1	Yes	No	0	5	0	1
L:L:Y37	R:R:W79	12.54	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:W128	11.28	0	Yes	Yes	0	5	0	1
L:L:?38	R:R:Y131	5.8	0	Yes	Yes	0	5	0	1
R:R:R213	R:R:V43	6.54	0	No	No	2	2	1	2
R:R:M48	R:R:W79	5.82	1	No	Yes	6	6	2	1
R:R:M48	R:R:Y98	10.78	1	No	Yes	6	4	2	2
R:R:G78	R:R:W76	7.04	0	No	Yes	5	8	1	2
R:R:D77	R:R:S129	7.36	1	No	Yes	9	7	2	2
R:R:D77	R:R:Y131	11.49	1	No	Yes	9	5	2	1
R:R:W79	R:R:Y98	4.82	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	6.01	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	17.36	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:P96	9.85	1	Yes	Yes	5	9	2	2
R:R:L80	R:R:V108	4.47	1	Yes	Yes	5	7	2	2
R:R:L80	R:R:Y131	8.21	1	Yes	Yes	5	5	2	1
R:R:C95	R:R:P96	3.77	1	Yes	Yes	9	9	2	2
R:R:C95	R:R:F102	6.98	1	Yes	Yes	9	4	2	1
R:R:C95	R:R:V108	3.42	1	Yes	Yes	9	7	2	2
R:R:C134	R:R:C95	7.28	1	No	Yes	9	9	2	2
R:R:P96	R:R:Y98	12.52	1	Yes	Yes	9	4	2	2
R:R:F102	R:R:P96	5.78	1	Yes	Yes	4	9	1	2
R:R:P96	R:R:Y131	4.17	1	Yes	Yes	9	5	2	1
R:R:D97	R:R:P104	4.83	0	No	No	2	3	1	1
R:R:F99	R:R:Y98	9.28	1	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	12.86	1	Yes	Yes	4	5	1	1
R:R:F102	R:R:Y131	3.09	1	Yes	Yes	4	5	1	1
R:R:C134	R:R:F102	15.36	1	No	Yes	9	4	2	1
R:R:D103	R:R:P104	6.44	5	Yes	No	3	3	1	1
R:R:D103	R:R:S105	4.42	5	Yes	No	3	1	1	1
R:R:D103	R:R:E106	9.09	5	Yes	No	3	4	1	2
R:R:E106	R:R:S105	2.87	5	No	No	4	1	2	1
R:R:V108	R:R:Y131	13.88	1	Yes	Yes	7	5	2	1
R:R:H121	R:R:P122	9.15	0	No	No	4	5	1	2
R:R:H121	R:R:W128	25.39	0	No	Yes	4	5	1	1
R:R:N130	R:R:W128	11.3	4	Yes	Yes	8	5	2	1
R:R:S129	R:R:Y131	5.09	1	Yes	Yes	7	5	2	1
R:R:C134	R:R:Y131	2.69	1	No	Yes	9	5	2	1
R:R:F137	R:R:K141	4.96	0	No	No	1	3	2	1
R:R:K141	R:R:K366	5.75	0	No	No	3	3	1	2
R:R:L142	R:R:Y146	8.21	5	No	Yes	2	2	1	1
R:R:D373	R:R:L148	5.43	0	No	Yes	5	5	2	1
R:R:H377	R:R:L148	16.71	6	Yes	Yes	7	5	1	1
R:R:Y149	R:R:Y150	8.94	0	Yes	No	5	4	1	1
R:R:L202	R:R:Y149	7.03	0	No	Yes	7	5	2	1
R:R:P207	R:R:Y149	2.78	0	No	Yes	3	5	2	1
R:R:I153	R:R:Y150	4.84	0	No	No	7	4	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	13.26	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	11.94	0	Yes	Yes	7	9	2	1
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:M230	R:R:N194	2.8	2	Yes	No	6	8	1	2
R:R:H226	R:R:I197	5.3	2	Yes	No	6	5	1	2
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	2
R:R:H226	R:R:I198	6.63	2	Yes	Yes	6	7	1	1
R:R:H201	R:R:V205	8.3	0	Yes	No	6	7	1	2
R:R:H201	R:R:V206	2.77	0	Yes	No	6	3	1	2
R:R:H201	R:R:L291	3.86	0	Yes	Yes	6	6	1	1
R:R:P207	R:R:V206	5.3	0	No	No	3	3	2	2
R:R:E210	R:R:N208	3.94	0	No	No	3	3	1	2
R:R:C289	R:R:V212	3.42	7	Yes	Yes	9	3	2	1
R:R:L291	R:R:V212	2.98	7	Yes	Yes	6	3	1	1
R:R:H223	R:R:Q227	12.36	0	No	Yes	5	7	2	1
R:R:H226	R:R:Q227	6.18	2	Yes	Yes	6	7	1	1
R:R:I301	R:R:Q227	6.86	0	No	Yes	7	7	2	1
R:R:M230	R:R:Y234	5.99	2	Yes	Yes	6	7	1	1
R:R:H302	R:R:M230	6.57	2	Yes	Yes	6	6	1	1
R:R:M237	R:R:Y234	4.79	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	10.09	2	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	13.41	2	Yes	Yes	7	7	1	1
R:R:L309	R:R:M237	2.83	0	No	Yes	7	9	2	2
R:R:M237	R:R:Q383	8.16	2	Yes	Yes	9	9	2	2
R:R:C289	R:R:L291	3.17	7	Yes	Yes	9	6	2	1
R:R:E294	R:R:S292	2.87	0	No	No	3	4	1	2
R:R:L298	R:R:V293	2.98	2	No	No	6	6	1	1
R:R:H296	R:R:Y299	3.27	0	No	Yes	2	7	2	1
R:R:H302	R:R:L298	3.86	2	Yes	No	6	6	1	1
R:R:F356	R:R:L309	4.87	2	Yes	No	7	7	1	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	12.88	2	Yes	Yes	7	8	1	2
R:R:M376	R:R:Q355	2.72	2	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	11.52	2	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	3.77	2	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	2	Yes	Yes	7	9	1	2
R:R:F359	R:R:Y372	4.13	2	Yes	Yes	6	7	2	2
R:R:F359	R:R:M376	6.22	2	Yes	Yes	6	7	2	1
R:R:P363	R:R:R362	2.88	2	No	Yes	7	4	2	1
R:R:G369	R:R:R362	6	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	7.2	2	Yes	Yes	4	7	1	2
R:R:D373	R:R:R362	11.91	0	No	Yes	5	4	2	1
R:R:P363	R:R:Y372	8.34	2	No	Yes	7	7	2	2
R:R:M376	R:R:Y372	11.97	2	Yes	Yes	7	7	1	2
R:R:I380	R:R:M376	2.92	0	No	Yes	6	7	2	1
R:R:H377	R:R:H381	10.75	6	Yes	Yes	7	9	1	1
R:R:H381	R:R:I380	3.98	0	Yes	No	9	6	1	2
L:L:V32	R:R:F102	2.62	0	No	Yes	0	4	0	1
E:E:A77	E:E:W84	2.59	0	No	Yes	7	9	2	1
R:R:H201	R:R:L222	2.57	0	Yes	No	6	6	1	2
L:L:S20	R:R:Y146	2.54	0	No	Yes	0	2	0	1
L:L:F15	R:R:K141	2.48	5	Yes	No	0	3	0	1
R:R:L148	R:R:Y374	2.34	6	Yes	Yes	5	6	1	2
R:R:E294	R:R:F94	2.33	0	No	No	3	3	1	2
L:L:Y37	R:R:R126	2.06	1	Yes	No	0	4	0	1
L:L:P29	R:R:N135	1.63	0	No	No	0	3	0	1
L:L:A5	R:R:M306	1.61	0	No	No	0	4	0	1
L:L:A5	R:R:M376	1.61	0	No	Yes	0	7	0	1
R:R:D103	R:R:T138	1.45	5	Yes	No	3	2	1	2
R:R:F99	R:R:P100	1.44	1	Yes	No	5	4	1	2
L:L:N21	R:R:E210	1.31	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F2A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.65
Number of Linked Nodes	499
Number of Links	658
Number of Hubs	127
Number of Links mediated by Hubs	446
Number of Communities	13
Number of Nodes involved in Communities	177
Number of Links involved in Communities	277

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	523446
Length Of Smallest Path	3
Average Path Length	21.4526
Length of Longest Path	40
Minimum Path Strength	1.2
Average Path Strength	6.37188
Maximum Path Strength	21.455
Minimum Path Correlation	0.7
Average Path Correlation	0.960793
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	47.5005
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	56.1239
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?201 H:H:?202 H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP3
UniProt	O60896
Sequence	>8F2A_nogp_Chain_E C N E T G M L E R L P L C G K A F A D M M G K V D V W K W C N L S E F I V Y Y E S F T N C T E M E A N V V G C Y W P N P L A Q G F I T G I H R Q F F S N C T V D R V H L E D P P D E V L I P L I V I P V V L T V A M A G L V V W R S K R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Pramlintide Analogue San385
UniProt	P10997
Sequence	>8F2A_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>8F2A_nogp_Chain_R Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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