CodeD6M
NameN-hexadecanoyl-L-glutamic acid
Synonyms
Identifier(2S)-2-(hexadecanoylamino)pentanedioic acid
FormulaC21 H39 N O5
Molecular Weight385.538
SMILESCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem161955
Formal Charge0
Total Atoms66
Total Chiral Atoms1
Total Bonds65
Total Aromatic Bonds0
Networks8
 missing image

This ligand is also present in the following 8 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7V35 B1 Peptide Glucagon Glucagon Homo sapiens Peptide-20 - Gs/Beta1/Gamma2 3.5 2022-03-02 10.1038/s41467-022-28683-0

A 2D representation of the interactions of D6M in 7V35
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K10 L:L:L14 4.23 2 No Yes 0 0 1 2
L:L:K10 R:R:Q142 13.56 2 No Yes 0 5 1 1
L:L:?29 L:L:K10 11.96 2 Yes No 0 0 0 1
L:L:?29 R:R:S139 11.32 2 Yes No 0 3 0 1
R:R:Q142 R:R:Y145 4.51 2 Yes Yes 5 7 1 2
R:R:D195 R:R:Q142 5.22 2 No Yes 7 5 2 1
R:R:Q142 R:R:R199 3.5 2 Yes Yes 5 4 1 1
L:L:?29 R:R:Q142 17.55 2 Yes Yes 0 5 0 1
L:L:?29 R:R:V143 4.21 2 Yes No 0 4 0 1
R:R:D195 R:R:Y145 4.6 2 No Yes 7 7 2 2
L:L:?29 R:R:T146 2.78 2 Yes No 0 7 0 1
L:L:?29 R:R:L192 7.82 2 Yes No 0 7 0 1
R:R:D195 R:R:R199 11.91 2 No Yes 7 4 2 1
R:R:G196 R:R:R199 3 0 No Yes 3 4 2 1
L:L:?29 R:R:R199 36.62 2 Yes Yes 0 4 0 1
R:R:S189 R:R:V193 1.62 0 No No 4 5 2 1
R:R:K136 R:R:S139 1.53 0 No No 2 3 2 1
R:R:L197 R:R:V193 1.49 0 No No 4 5 2 1
L:L:?29 R:R:V193 1.4 2 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength11.71
Average Nodes In Shell16.00
Average Hubs In Shell5.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VBH B1 Peptide Glucagon GLP-1 Homo sapiens Peptide-20 - Gs/Beta1/Gamma2 3 2022-04-06 10.1038/s41467-022-28683-0

A 2D representation of the interactions of D6M in 7VBH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K10 R:R:L141 9.87 0 No No 0 5 1 2
L:L:?30 L:L:K10 14.61 2 Yes No 0 0 0 1
R:R:I146 R:R:L142 4.28 2 No No 4 3 1 1
L:L:?30 R:R:L142 6.52 2 Yes No 0 3 0 1
R:R:Y145 R:R:Y148 5.96 2 Yes Yes 5 7 1 2
R:R:T149 R:R:Y145 13.73 2 No Yes 7 5 1 1
R:R:D198 R:R:Y145 6.9 2 No Yes 7 5 2 1
L:L:?30 R:R:Y145 8.83 2 Yes Yes 0 5 0 1
L:L:?30 R:R:I146 4.03 2 Yes No 0 4 0 1
R:R:T149 R:R:Y148 3.75 2 No Yes 7 7 1 2
R:R:D198 R:R:Y148 9.2 2 No Yes 7 7 2 2
L:L:?30 R:R:T149 4.17 2 Yes No 0 7 0 1
L:L:?30 R:R:A153 5.94 2 Yes No 0 6 0 1
R:R:K202 R:R:W203 4.64 0 No No 4 3 1 2
L:L:?30 R:R:K202 13.28 2 Yes No 0 4 0 1
L:L:?30 R:R:V150 2.81 2 Yes No 0 5 0 1
L:L:?30 R:R:L154 2.61 2 Yes No 0 5 0 1
R:R:E139 R:R:L142 1.33 0 No No 2 3 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.98
Average Nodes In Shell15.00
Average Hubs In Shell3.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell14.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F0J B1 Peptide Calcitonin CT Homo Sapiens Pramlintide analogue san45 - Gs/Beta1/Gamma2 2 2023-08-02 10.1038/s41589-023-01393-4

A 2D representation of the interactions of D6M in 8F0J
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L16 R:R:Y146 8.21 0 No No 0 2 2 1
L:L:L16 R:R:Y149 4.69 0 No Yes 0 5 2 1
L:L:K21 L:L:S19 3.06 14 Yes No 0 0 1 2
L:L:K21 R:R:Y146 9.55 14 Yes No 0 2 1 1
L:L:K21 R:R:Y149 3.58 14 Yes Yes 0 5 1 1
L:L:K21 R:R:P207 6.69 14 Yes Yes 0 3 1 1
L:L:?101 L:L:K21 14.61 14 Yes Yes 0 0 0 1
L:L:N22 R:R:P207 4.89 14 No Yes 0 3 1 1
L:L:?101 L:L:N22 3.88 14 Yes No 0 0 0 1
L:L:?101 R:R:Y146 7.73 14 Yes No 0 2 0 1
R:R:Y149 R:R:Y150 8.94 14 Yes No 5 4 1 1
R:R:I153 R:R:Y149 8.46 14 No Yes 7 5 1 1
R:R:L202 R:R:Y149 8.21 0 No Yes 7 5 2 1
L:L:?101 R:R:Y149 9.94 14 Yes Yes 0 5 0 1
L:L:?101 R:R:Y150 7.73 14 Yes No 0 4 0 1
L:L:?101 R:R:I153 8.07 14 Yes No 0 7 0 1
L:L:?101 R:R:S157 11.32 14 Yes No 0 7 0 1
R:R:I160 R:R:S195 4.64 0 No No 5 7 1 2
R:R:I160 R:R:M196 4.37 0 No No 5 4 1 2
L:L:?101 R:R:I160 4.03 14 Yes No 0 5 0 1
R:R:F161 R:R:I165 6.28 0 No No 4 5 1 2
L:L:?101 R:R:F161 4.59 14 Yes No 0 4 0 1
L:L:?101 R:R:I199 4.03 14 Yes No 0 7 0 1
R:R:E204 R:R:V203 5.7 0 No No 4 3 2 1
L:L:?101 R:R:V203 5.61 14 Yes No 0 3 0 1
R:R:P207 R:R:V206 3.53 14 Yes No 3 3 1 2
L:L:?101 R:R:P207 12.38 14 Yes Yes 0 3 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.83
Average Nodes In Shell21.00
Average Hubs In Shell4.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F2B B1 Peptide Calcitonin CT (AMY3) Homo Sapiens Pramlintide analogue san45 - Gs/Beta1/Gamma2; RAMP3 2 2023-08-02 10.1038/s41589-023-01393-4

A 2D representation of the interactions of D6M in 8F2B
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F23 L:L:L16 3.65 0 No Yes 0 0 2 2
L:L:L16 R:R:Y149 4.69 0 Yes Yes 0 5 2 1
L:L:L16 R:R:V206 2.98 0 Yes Yes 0 3 2 2
L:L:F23 L:L:K21 6.2 0 No Yes 0 0 2 1
L:L:K21 R:R:Y149 8.36 9 Yes Yes 0 5 1 1
L:L:K21 R:R:V206 3.04 9 Yes Yes 0 3 1 2
L:L:K21 R:R:P207 13.38 9 Yes No 0 3 1 1
L:L:?101 L:L:K21 14.61 9 Yes Yes 0 0 0 1
L:L:F23 R:R:Y146 19.6 0 No No 0 2 2 2
R:R:Y146 R:R:Y150 7.94 0 No No 2 4 2 1
R:R:Y149 R:R:Y150 7.94 9 Yes No 5 4 1 1
R:R:I153 R:R:Y149 3.63 9 No Yes 7 5 1 1
R:R:L202 R:R:Y149 8.21 9 No Yes 7 5 2 1
L:L:?101 R:R:Y149 6.63 9 Yes Yes 0 5 0 1
L:L:?101 R:R:Y150 4.42 9 Yes No 0 4 0 1
R:R:I153 R:R:L202 5.71 9 No No 7 7 1 2
L:L:?101 R:R:I153 5.38 9 Yes No 0 7 0 1
L:L:?101 R:R:S157 11.32 9 Yes No 0 7 0 1
R:R:I160 R:R:S195 4.64 0 No No 5 7 1 2
R:R:I160 R:R:M196 5.83 0 No No 5 4 1 2
L:L:?101 R:R:I160 5.38 9 Yes No 0 5 0 1
R:R:F161 R:R:I165 5.02 0 No No 4 5 1 2
L:L:?101 R:R:F161 5.74 9 Yes No 0 4 0 1
R:R:I192 R:R:V164 3.07 0 No No 7 4 2 1
L:L:?101 R:R:V164 5.61 9 Yes No 0 4 0 1
R:R:E204 R:R:V203 4.28 0 No No 4 3 2 1
L:L:?101 R:R:V203 7.02 9 Yes No 0 3 0 1
R:R:P207 R:R:V206 5.3 9 No Yes 3 3 1 2
L:L:?101 R:R:P207 9.28 9 Yes No 0 3 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.54
Average Nodes In Shell21.00
Average Hubs In Shell5.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JIP B1 Peptide Glucagon GLP-1 Homo Sapiens MEDI0382 - chim(NtGi1-Gs)/Beta1/Gamma2 2.85 2023-09-06 10.1073/pnas.2303696120

A 2D representation of the interactions of D6M in 8JIP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I146 R:R:L142 4.28 0 No No 4 3 1 2
R:R:D198 R:R:Y145 6.9 0 No No 7 5 2 1
L:L:?1 R:R:Y145 23.19 0 Yes No 0 5 0 1
L:L:?1 R:R:I146 4.03 0 Yes No 0 4 0 1
L:L:?1 R:R:T149 4.17 0 Yes No 0 7 0 1
L:L:?1 R:R:A153 4.45 0 Yes No 0 6 0 1
R:R:L154 R:R:L396 2.77 0 No No 5 7 1 2
L:L:?1 R:R:L154 10.43 0 Yes No 0 5 0 1
L:L:?1 R:R:S157 4.24 0 Yes No 0 3 0 1
R:R:K202 R:R:T207 16.52 0 No No 4 3 1 2
L:L:?1 R:R:K202 19.93 0 Yes No 0 4 0 1
L:L:?1 L:L:K10 11.96 0 Yes No 0 0 0 1
R:R:T149 R:R:V150 1.59 0 No No 7 5 1 2
R:R:A153 R:R:F195 1.39 0 No No 6 7 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub0.00
Average Interaction Strength10.30
Average Nodes In Shell15.00
Average Hubs In Shell1.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell8.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JIR B1 Peptide Glucagon GLP-1 Homo Sapiens SAR425899 - chim(NtGi1-Gs)/Beta1/Gamma2 2.57 2023-09-06 10.1073/pnas.2303696120

A 2D representation of the interactions of D6M in 8JIR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F6 R:R:Y145 3.09 6 Yes Yes 0 5 2 1
L:L:F6 R:R:Y148 11.35 6 Yes Yes 0 7 2 2
L:L:K14 R:R:K202 2.87 6 No Yes 0 4 1 1
L:L:?1 L:L:K14 11.96 6 Yes No 0 0 0 1
R:R:I146 R:R:L142 2.85 6 No No 4 3 1 1
L:L:?1 R:R:L142 13.04 6 Yes No 0 3 0 1
R:R:Y145 R:R:Y148 3.97 6 Yes Yes 5 7 1 2
R:R:T149 R:R:Y145 11.24 6 No Yes 7 5 1 1
R:R:D198 R:R:Y145 13.79 0 No Yes 7 5 2 1
R:R:K202 R:R:Y145 3.58 6 Yes Yes 4 5 1 1
L:L:?1 R:R:Y145 6.63 6 Yes Yes 0 5 0 1
L:L:?1 R:R:I146 8.07 6 Yes No 0 4 0 1
R:R:T149 R:R:Y148 3.75 6 No Yes 7 7 1 2
L:L:?1 R:R:T149 4.17 6 Yes No 0 7 0 1
R:R:G151 R:R:V150 3.68 6 No No 8 5 2 1
L:L:?1 R:R:V150 4.21 6 Yes No 0 5 0 1
L:L:?1 R:R:A153 5.94 6 Yes No 0 6 0 1
L:L:?1 R:R:L154 3.91 6 Yes No 0 5 0 1
R:R:K202 R:R:S206 3.06 6 Yes No 4 4 1 2
L:L:?1 R:R:K202 6.64 6 Yes Yes 0 4 0 1
L:L:K14 L:L:L10 2.82 6 No No 0 0 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.17
Average Nodes In Shell16.00
Average Hubs In Shell5.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JIT B1 Peptide Glucagon Glucagon Homo Sapiens MEDI0382 - Gs/Beta1/Gamma2 2.91 2023-09-06 10.1073/pnas.2303696120

A 2D representation of the interactions of D6M in 8JIT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K10 L:L:L14 11.28 9 Yes No 0 0 1 2
L:L:K10 R:R:Y138 3.58 9 Yes Yes 0 5 1 2
L:L:K10 R:R:Q142 6.78 9 Yes Yes 0 5 1 1
L:L:?1 L:L:K10 14.61 9 Yes Yes 0 0 0 1
L:L:?1 R:R:S139 11.32 9 Yes No 0 3 0 1
R:R:Q142 R:R:Y145 14.65 9 Yes Yes 5 7 1 2
R:R:D195 R:R:Q142 3.92 9 No Yes 7 5 2 1
L:L:?1 R:R:Q142 25.08 9 Yes Yes 0 5 0 1
L:L:?1 R:R:V143 7.02 9 Yes No 0 4 0 1
R:R:T146 R:R:Y145 3.75 0 No Yes 7 7 1 2
R:R:D195 R:R:Y145 11.49 9 No Yes 7 7 2 2
R:R:L192 R:R:T146 4.42 0 No No 7 7 2 1
L:L:?1 R:R:T146 9.72 9 Yes No 0 7 0 1
R:R:G148 R:R:V147 3.68 0 No No 7 5 2 1
L:L:?1 R:R:V147 5.61 9 Yes No 0 5 0 1
L:L:?1 R:R:S150 7.07 9 Yes No 0 7 0 1
L:L:?1 R:R:L151 5.22 9 Yes No 0 5 0 1
R:R:G196 R:R:R199 4.5 0 No No 3 4 2 1
L:L:?1 R:R:R199 22.89 9 Yes No 0 4 0 1
R:R:R199 R:R:S203 1.32 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength12.06
Average Nodes In Shell18.00
Average Hubs In Shell5.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JIU B1 Peptide Glucagon Glucagon Homo Sapiens SAR425899 - Gs/Beta1/Gamma2 2.76  2023-09-13 10.1073/pnas.2303696120

A 2D representation of the interactions of D6M in 8JIU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K14 L:L:L10 4.23 0 No No 0 0 1 2
L:L:L10 R:R:Q142 3.99 0 No Yes 0 5 2 1
L:L:K14 R:R:Y202 9.55 0 No Yes 0 1 1 2
L:L:?1 L:L:K14 15.94 6 Yes No 0 0 0 1
L:L:?1 R:R:S139 4.24 6 Yes No 0 3 0 1
R:R:Q142 R:R:Y145 5.64 6 Yes Yes 5 7 1 2
R:R:D195 R:R:Q142 3.92 6 Yes Yes 7 5 2 1
R:R:Q142 R:R:R199 3.5 6 Yes No 5 4 1 1
L:L:?1 R:R:Q142 16.3 6 Yes Yes 0 5 0 1
L:L:?1 R:R:V143 7.02 6 Yes No 0 4 0 1
R:R:D195 R:R:Y145 3.45 6 Yes Yes 7 7 2 2
R:R:L192 R:R:T146 4.42 0 No No 7 7 2 1
L:L:?1 R:R:T146 13.89 6 Yes No 0 7 0 1
R:R:G148 R:R:V147 3.68 0 No No 7 5 2 1
L:L:?1 R:R:V147 8.42 6 Yes No 0 5 0 1
L:L:?1 R:R:S150 8.49 6 Yes No 0 7 0 1
L:L:?1 R:R:L151 10.43 6 Yes No 0 5 0 1
R:R:D195 R:R:R199 7.15 6 Yes No 7 4 2 1
L:L:?1 R:R:R199 29.75 6 Yes No 0 4 0 1
R:R:K205 R:R:S203 1.53 0 No No 4 4 2 1
L:L:?1 R:R:S203 1.41 6 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub1.00
Average Interaction Strength11.59
Average Nodes In Shell18.00
Average Hubs In Shell5.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.38
Average Number Of Links With An Hub1.62
Average Interaction Strength9.40
Average Nodes In Shell17.50
Average Hubs In Shell4.12
Average Links In Shell21.12
Average Links Mediated by Hubs In Shell16.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)