psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:R1	4.32	Yes	No	5	0	0
2	L:L:R1	L:L:Y3	13.38	No	No	0	0	0
3	L:L:R1	R:R:W334	12	No	Yes	5	0	4
4	L:L:P2	R:R:W334	18.92	Yes	Yes	5	0	4
5	L:L:P2	R:R:Y339	4.17	Yes	Yes	5	0	2
6	L:L:P2	R:R:Y342	4.17	Yes	Yes	0	0	4
7	L:L:Y3	R:R:R212	18.52	No	No	0	0	1
8	L:L:I4	R:R:V223	3.07	No	No	0	0	4
9	L:L:L5	R:R:M207	5.65	No	Yes	0	0	6
10	L:L:L5	R:R:P226	6.57	No	No	0	0	5
11	L:L:L5	R:R:F326	3.65	No	No	0	0	4
12	R:R:A49	R:R:S52	3.42	No	No	0	6	6
13	R:R:D215	R:R:P50	3.22	Yes	No	13	2	4
14	R:R:H218	R:R:P50	10.68	No	No	13	3	4
15	R:R:H131	R:R:S51	4.18	No	No	0	3	3
16	R:R:E53	R:R:S52	5.75	No	No	0	2	6
17	R:R:V56	R:R:Y339	5.05	No	Yes	5	2	2
18	R:R:H343	R:R:V56	19.37	No	No	5	4	2
19	R:R:D340	R:R:N57	12.12	No	No	0	1	2
20	R:R:T58	R:R:Y344	8.74	No	No	0	1	1
21	R:R:D59	R:R:S62	5.89	No	No	0	3	3
22	R:R:K63	R:R:T67	3	No	No	0	5	6
23	R:R:F127	R:R:K63	13.65	No	No	0	4	5
24	R:R:I128	R:R:K63	10.18	No	No	0	4	5
25	R:R:L65	R:R:V69	2.98	No	No	0	5	4
26	R:R:M347	R:R:V66	10.65	No	No	0	3	5
27	R:R:M120	R:R:Y70	8.38	Yes	Yes	9	8	7
28	R:R:L124	R:R:Y70	7.03	No	Yes	9	6	7
29	R:R:N350	R:R:Y70	8.14	No	Yes	0	6	7
30	R:R:Y354	R:R:Y70	22.84	Yes	Yes	9	7	7
31	R:R:L73	R:R:Y354	17.58	No	Yes	9	7	7
32	R:R:L73	R:R:T358	14.74	No	No	9	7	7
33	R:R:F74	R:R:T78	7.78	No	No	0	7	6
34	R:R:F74	R:R:L116	2.44	No	Yes	0	7	7
35	R:R:F74	R:R:M120	7.46	No	Yes	0	7	8
36	R:R:T358	R:R:V76	3.17	No	No	0	7	6
37	R:R:F375	R:R:V79	2.62	No	No	0	7	5
38	R:R:G80	R:R:P361	4.06	No	No	0	9	9
39	R:R:N81	R:R:T82	2.92	No	No	0	9	4
40	R:R:D112	R:R:N81	5.39	No	No	0	9	9
41	R:R:L113	R:R:N81	8.24	No	No	0	7	9
42	R:R:F375	R:R:V83	17.04	No	No	0	7	6
43	R:R:T378	R:R:V83	6.35	No	No	0	5	6
44	R:R:L88	R:R:T84	2.95	Yes	No	0	7	9
45	R:R:A109	R:R:T84	3.36	No	No	0	9	9
46	R:R:F86	R:R:R90	5.34	No	No	0	4	5
47	R:R:F86	R:R:I374	5.02	No	Yes	11	4	6
48	R:R:F86	R:R:T378	2.59	No	No	11	4	5
49	R:R:F371	R:R:T87	7.78	Yes	No	11	8	7
50	R:R:I374	R:R:T87	7.6	Yes	No	11	6	7
51	R:R:K91	R:R:L88	8.46	No	Yes	15	5	7
52	R:R:H102	R:R:L88	10.29	No	Yes	15	8	7
53	R:R:L105	R:R:L88	4.15	No	Yes	0	8	7
54	R:R:K91	R:R:L97	5.64	No	No	0	5	8
55	R:R:H102	R:R:K91	14.41	No	No	15	8	5
56	R:R:L94	R:R:L97	6.92	No	No	0	5	8
57	R:R:L94	V:V:R285	10.93	No	No	0	5	7
58	R:R:Q95	V:V:Y249	10.15	Yes	No	0	4	7
59	R:R:Q95	V:V:C251	3.05	Yes	Yes	0	4	6
60	R:R:Q95	V:V:K284	2.71	Yes	Yes	0	4	8
61	R:R:Q95	V:V:R285	3.5	Yes	No	0	4	7
62	R:R:Q95	V:V:G286	6.58	Yes	No	0	4	9
63	R:R:S96	V:V:Y249	5.09	No	No	0	6	7
64	R:R:L97	V:V:E66	6.63	No	No	0	8	7
65	R:R:Q98	R:R:S99	2.89	Yes	No	0	7	8
66	R:R:Q98	R:R:T100	8.5	Yes	No	0	7	7
67	R:R:Q98	R:R:V101	4.3	Yes	No	0	7	8
68	R:R:Q98	V:V:R65	10.51	Yes	No	0	7	7
69	R:R:R182	R:R:S99	5.27	No	No	0	3	8
70	R:R:T100	R:R:T185	9.42	No	No	0	7	7
71	R:R:L105	R:R:V101	5.96	No	No	0	8	8
72	R:R:T185	R:R:Y103	3.75	No	No	0	7	5
73	R:R:K186	R:R:Y103	8.36	No	No	0	3	5
74	R:R:I189	R:R:Y103	19.34	Yes	No	0	7	5
75	R:R:H104	R:R:N158	2.55	Yes	No	0	8	8
76	R:R:H104	R:R:S161	4.18	Yes	No	0	8	7
77	R:R:E165	R:R:H104	3.69	No	Yes	0	8	8
78	R:R:H104	R:R:T185	4.11	Yes	No	0	8	7
79	R:R:L105	R:R:Y364	12.89	No	No	0	8	9
80	R:R:N158	R:R:S107	5.96	No	No	0	8	9
81	R:R:I189	R:R:S107	6.19	Yes	No	16	7	9
82	R:R:S107	R:R:W193	4.94	No	No	16	9	9
83	R:R:L108	R:R:N158	8.24	No	No	0	9	8
84	R:R:L108	R:R:N360	8.24	No	No	0	9	9
85	R:R:S111	R:R:T155	3.2	No	No	0	8	9
86	R:R:D112	R:R:L116	4.07	No	Yes	0	9	7
87	R:R:L114	R:R:L118	11.07	No	No	0	8	5
88	R:R:C151	R:R:L114	7.94	No	No	0	7	8
89	R:R:L116	R:R:T115	2.95	Yes	Yes	14	7	7
90	R:R:R148	R:R:T115	6.47	Yes	Yes	0	7	7
91	R:R:C151	R:R:T115	5.07	No	Yes	0	7	7
92	R:R:S357	R:R:T115	3.2	No	Yes	14	9	7
93	R:R:L116	R:R:S357	7.51	Yes	No	14	7	9
94	R:R:L118	R:R:Y144	3.52	No	No	0	5	6
95	R:R:A119	R:R:R148	2.77	No	Yes	0	7	7
96	R:R:M120	R:R:P121	11.74	Yes	No	0	8	9
97	R:R:L124	R:R:M120	5.65	No	Yes	9	6	8
98	R:R:V122	R:R:W134	2.45	No	Yes	0	6	8
99	R:R:V122	R:R:Y144	20.19	No	No	0	6	6
100	R:R:E123	R:R:N126	3.94	No	No	0	6	5
101	R:R:E123	R:R:N350	9.2	No	No	0	6	6
102	R:R:W129	R:R:Y125	3.86	No	No	0	5	5
103	R:R:F127	R:R:N126	2.42	No	No	0	4	5
104	R:R:F127	R:R:M347	2.49	No	No	0	4	3
105	R:R:I128	R:R:W129	12.92	No	No	0	4	5
106	R:R:H131	R:R:V130	5.54	No	No	0	3	5
107	R:R:G220	R:R:H132	9.53	No	No	0	5	4
108	R:R:F136	R:R:W134	6.01	No	Yes	0	7	8
109	R:R:C141	R:R:W134	13.06	Yes	Yes	8	9	8
110	R:R:W134	R:R:Y145	3.86	Yes	Yes	8	8	4
111	R:R:C224	R:R:W134	9.14	No	Yes	8	9	8
112	R:R:A135	R:R:F136	2.77	No	No	0	3	7
113	R:R:E209	R:R:G137	3.27	No	No	0	5	8
114	R:R:A139	R:R:D138	3.09	No	No	0	1	3
115	R:R:D138	R:R:R142	15.48	No	No	0	3	7
116	R:R:C141	R:R:Y145	2.69	Yes	Yes	8	9	4
117	R:R:C141	R:R:M207	3.24	Yes	Yes	8	9	6
118	R:R:C141	R:R:C224	5.46	Yes	No	8	9	9
119	R:R:G208	R:R:R142	4.5	No	No	0	4	7
120	R:R:R148	R:R:Y144	11.32	Yes	No	0	7	6
121	R:R:M203	R:R:Y145	7.18	No	Yes	8	5	4
122	R:R:M207	R:R:Y145	3.59	Yes	Yes	8	6	4
123	R:R:A200	R:R:F146	5.55	No	No	0	7	6
124	R:R:F146	R:R:L204	12.18	No	No	0	6	5
125	R:R:R148	R:R:T152	3.88	Yes	No	0	7	7
126	R:R:F353	R:R:R148	3.21	Yes	Yes	0	7	7
127	R:R:A200	R:R:D149	3.09	No	No	0	7	5
128	R:R:D149	R:R:N240	5.39	No	No	0	5	6
129	R:R:S196	R:R:Y153	5.09	No	Yes	10	8	7
130	R:R:L199	R:R:Y153	11.72	No	Yes	10	6	7
131	R:R:M243	R:R:Y153	10.78	No	Yes	10	5	7
132	R:R:A154	R:R:L157	3.15	No	No	10	7	6
133	R:R:A154	R:R:S196	3.42	No	No	10	7	8
134	R:R:I192	R:R:L157	21.41	No	No	0	7	6
135	R:R:L157	R:R:S196	3	No	No	10	6	8
136	R:R:F312	R:R:V159	5.24	No	No	0	9	8
137	R:R:I252	R:R:S163	4.64	No	No	0	8	9
138	R:R:L255	R:R:V164	2.98	No	No	0	7	7
139	R:R:E165	R:R:M180	6.77	No	No	0	8	7
140	R:R:A169	R:R:R166	2.77	No	No	0	8	9
141	R:R:I259	R:R:R166	2.51	Yes	No	0	9	9
142	R:R:C171	R:R:Y167	9.41	No	Yes	0	7	8
143	R:R:L255	R:R:Y167	10.55	No	Yes	0	7	8
144	R:R:I258	R:R:Y167	14.51	No	Yes	0	5	8
145	R:R:I259	R:R:Y167	7.25	Yes	Yes	0	9	8
146	R:R:A176	R:R:L168	6.3	No	No	0	6	4
147	R:R:L168	R:R:M180	2.83	No	No	0	4	7
148	R:R:C171	R:R:I170	3.27	No	Yes	0	7	9
149	R:R:I170	R:R:I259	8.83	Yes	Yes	17	9	9
150	R:R:I170	R:R:K262	8.72	Yes	No	0	9	5
151	R:R:I170	R:R:L263	4.28	Yes	No	17	9	8
152	R:R:H172	R:R:K175	9.17	No	No	0	6	4
153	R:R:F174	R:R:K177	7.44	No	No	0	7	4
154	R:R:K175	R:R:L179	7.05	No	No	0	4	4
155	R:R:K177	R:R:T178	3	No	No	0	4	4
156	R:R:S181	R:R:S183	4.89	No	No	0	8	4
157	R:R:I189	R:R:S190	3.1	Yes	No	0	7	4
158	R:R:I189	R:R:I192	4.42	Yes	No	0	7	7
159	R:R:I189	R:R:W193	11.74	Yes	No	16	7	9
160	R:R:L199	R:R:M243	5.65	No	No	10	6	5
161	R:R:P202	R:R:V201	3.53	No	No	0	7	5
162	R:R:F205	R:R:P202	11.56	No	No	0	4	7
163	R:R:P202	R:R:V236	5.3	No	No	0	7	6
164	R:R:M203	R:R:M207	4.33	No	Yes	8	5	6
165	R:R:F205	R:R:T206	10.38	No	No	0	4	5
166	R:R:I228	R:R:T206	3.04	Yes	No	0	5	5
167	R:R:T206	R:R:V236	3.17	No	No	0	5	6
168	R:R:C224	R:R:M207	3.24	No	Yes	8	9	6
169	R:R:E209	R:R:L222	13.25	No	No	0	5	4
170	R:R:Q210	R:R:R212	4.67	No	No	0	1	1
171	R:R:Q210	R:R:T225	5.67	No	No	0	1	4
172	R:R:R212	R:R:V223	2.62	No	No	0	1	4
173	R:R:G221	R:R:S213	3.71	No	No	0	2	1
174	R:R:D215	R:R:H218	3.78	Yes	No	13	2	3
175	R:R:G220	R:R:H218	4.77	No	No	0	5	3
176	R:R:P226	R:R:V233	8.84	No	No	0	5	5
177	R:R:H229	R:R:I228	11.93	No	Yes	0	4	5
178	R:R:I228	R:R:T232	6.08	Yes	No	0	5	4
179	R:R:I228	R:R:V233	4.61	Yes	No	0	5	5
180	R:R:Q238	R:R:V235	2.87	No	No	0	5	4
181	R:R:I237	R:R:R323	11.27	No	Yes	0	6	6
182	R:R:F242	R:R:Q238	2.34	No	No	0	5	5
183	R:R:N240	R:R:R323	3.62	No	Yes	0	6	6
184	R:R:F242	R:R:T241	5.19	No	No	0	5	6
185	R:R:H320	R:R:T241	13.69	Yes	No	0	7	6
186	R:R:R323	R:R:T241	5.17	Yes	No	0	6	6
187	R:R:F247	R:R:M243	3.73	No	No	0	6	5
188	R:R:S244	R:R:Y319	3.82	No	No	0	6	6
189	R:R:F245	R:R:M249	3.73	Yes	No	4	8	6
190	R:R:F245	R:R:V313	3.93	Yes	No	4	8	7
191	R:R:F245	R:R:W316	8.02	Yes	Yes	4	8	8
192	R:R:F245	R:R:L317	7.31	Yes	Yes	4	8	7
193	R:R:F245	R:R:H320	4.53	Yes	Yes	4	8	7
194	R:R:F247	R:R:V251	2.62	No	No	0	6	6
195	R:R:M249	R:R:V313	6.09	No	No	4	6	7
196	R:R:L255	R:R:V251	2.98	No	No	0	7	6
197	R:R:I252	R:R:V308	3.07	No	No	0	8	8
198	R:R:S253	R:R:V254	3.23	No	No	0	5	5
199	R:R:L305	R:R:N256	9.61	Yes	No	0	8	9
200	R:R:N256	R:R:V309	5.91	No	No	0	9	8
201	R:R:I259	R:R:L263	2.85	Yes	No	17	9	8
202	R:R:I259	R:R:L305	4.28	Yes	Yes	0	9	8
203	R:R:N261	R:R:V265	4.43	No	No	0	4	4
204	R:R:K262	R:R:V265	3.04	No	No	0	5	4
205	R:R:K262	R:R:M266	12.96	No	No	0	5	6
206	R:R:L263	R:R:L298	6.92	No	No	0	8	7
207	R:R:M266	R:R:V267	4.56	No	No	0	6	6
208	R:R:M266	V:V:F75	2.49	No	No	0	6	9
209	R:R:V267	V:V:L73	10.43	No	No	0	6	8
210	R:R:R299	R:R:V295	2.62	No	No	0	5	3
211	R:R:Q296	R:R:R299	4.67	No	No	0	5	5
212	R:R:H300	R:R:Q296	2.47	No	No	0	8	5
213	R:R:L298	R:R:R299	6.07	No	No	0	7	5
214	R:R:R303	R:R:R306	12.79	No	No	0	7	5
215	R:R:V304	R:R:V367	3.21	No	No	0	8	7
216	R:R:I310	R:R:V314	3.07	No	No	0	5	6
217	R:R:F312	R:R:W316	20.04	No	Yes	0	9	8
218	R:R:C315	R:R:W316	2.61	Yes	Yes	4	9	8
219	R:R:C315	R:R:L352	3.17	Yes	No	0	9	7
220	R:R:C315	R:R:S356	5.16	Yes	No	4	9	9
221	R:R:F353	R:R:W316	19.04	Yes	Yes	0	7	8
222	R:R:S356	R:R:W316	11.12	No	Yes	4	9	8
223	R:R:L317	R:R:P318	4.93	Yes	No	0	7	9
224	R:R:H320	R:R:L317	6.43	Yes	Yes	4	7	7
225	R:R:L317	R:R:V321	4.47	Yes	No	4	7	5
226	R:R:P318	R:R:T349	6.99	No	No	0	9	6
227	R:R:L352	R:R:P318	3.28	No	No	0	7	9
228	R:R:F353	R:R:Y319	7.22	Yes	No	0	7	6
229	R:R:H320	R:R:V321	4.15	Yes	No	4	7	5
230	R:R:H320	R:R:L324	7.71	Yes	No	0	7	6
231	R:R:R322	R:R:R323	12.79	No	Yes	0	5	6
232	R:R:R322	R:R:Y342	9.26	No	Yes	0	5	4
233	R:R:R322	R:R:Y346	17.49	No	No	0	5	4
234	R:R:I329	R:R:M325	5.83	Yes	No	0	3	4
235	R:R:L338	R:R:M325	4.24	Yes	No	0	1	4
236	R:R:M325	R:R:Y342	8.38	No	Yes	0	4	4
237	R:R:F326	R:R:W334	3.01	No	Yes	0	4	4
238	R:R:F326	R:R:Y342	3.09	No	Yes	0	4	4
239	R:R:I329	R:R:Y328	14.51	Yes	No	0	3	5
240	R:R:I329	R:R:W334	29.36	Yes	Yes	0	3	4
241	R:R:D331	R:R:E332	3.9	No	No	0	1	1
242	R:R:L338	R:R:W334	4.56	Yes	Yes	5	1	4
243	R:R:F337	R:R:T335	6.49	No	No	5	2	4
244	R:R:L338	R:R:T335	7.37	Yes	No	5	1	4
245	R:R:F337	R:R:L338	10.96	No	Yes	5	2	1
246	R:R:H343	R:R:Y339	7.62	No	Yes	5	4	2
247	R:R:F341	R:R:F345	11.79	No	No	0	4	4
248	R:R:M347	R:R:Y344	2.39	No	No	0	3	1
249	R:R:T349	R:R:Y346	2.5	No	No	0	6	4
250	R:R:L352	R:R:V348	2.98	No	No	0	7	6
251	R:R:F353	R:R:T349	2.59	Yes	No	0	7	6
252	R:R:T358	R:R:Y354	2.5	No	Yes	9	7	7
253	R:R:I359	R:R:L363	12.85	No	No	0	6	8
254	R:R:N360	R:R:P361	9.77	No	No	0	9	9
255	R:R:I362	R:R:L366	2.85	No	No	0	6	6
256	R:R:V367	R:R:Y364	2.52	No	No	0	7	9
257	R:R:F371	R:R:Y364	11.35	Yes	No	0	8	9
258	R:R:F375	R:R:N365	13.29	No	No	0	7	7
259	R:R:F371	R:R:S368	10.57	Yes	No	0	8	8
260	R:R:F371	R:R:N370	8.46	Yes	No	0	8	7
261	R:R:F371	R:R:I374	2.51	Yes	Yes	11	8	6
262	R:R:I374	R:R:T378	3.04	Yes	No	11	6	5
263	R:R:H406	R:R:L408	3.86	No	No	0	8	3
264	R:R:S410	V:V:K11	3.06	No	No	1	6	9
265	R:R:S410	V:V:R25	2.64	No	Yes	1	6	9
266	R:R:A412	V:V:R7	2.77	No	No	0	6	4
267	R:R:T413	V:V:K10	9.01	No	No	0	7	9
268	R:R:E415	V:V:L100	2.65	No	No	1	6	5
269	R:R:E415	V:V:R103	15.12	No	No	1	6	6
270	R:R:E415	V:V:K107	2.7	No	Yes	1	6	9
271	V:V:F9	V:V:R7	13.9	No	No	0	6	4
272	V:V:G23	V:V:V8	3.68	No	No	0	8	7
273	V:V:F9	V:V:K24	2.48	No	No	0	6	7
274	V:V:F9	V:V:R25	11.76	No	Yes	0	6	9
275	V:V:K10	V:V:Y21	10.75	No	Yes	0	9	8
276	V:V:K11	V:V:R25	2.48	No	Yes	1	9	9
277	V:V:K11	V:V:V164	4.55	No	No	0	9	8
278	V:V:A12	V:V:T19	5.03	No	No	0	5	7
279	V:V:L18	V:V:S13	3	Yes	No	0	6	8
280	V:V:N15	V:V:R161	7.23	No	No	0	8	7
281	V:V:N15	V:V:N162	4.09	No	No	0	8	8
282	V:V:K17	V:V:L18	5.64	Yes	Yes	1	5	6
283	V:V:K17	V:V:V43	6.07	Yes	Yes	1	5	6
284	V:V:D44	V:V:K17	6.91	No	Yes	0	8	5
285	V:V:K17	V:V:N162	8.39	Yes	No	0	5	8
286	V:V:L18	V:V:V41	4.47	Yes	No	1	6	5
287	V:V:L18	V:V:V43	4.47	Yes	Yes	1	6	6
288	V:V:L18	V:V:V164	5.96	Yes	No	0	6	8
289	V:V:T19	V:V:Y21	8.74	No	Yes	0	7	8
290	V:V:V20	V:V:V41	6.41	No	No	1	6	5
291	V:V:V164	V:V:V20	4.81	No	No	0	8	6
292	V:V:V40	V:V:Y21	3.79	No	Yes	1	8	8
293	V:V:L104	V:V:Y21	2.34	No	Yes	1	9	8
294	V:V:L108	V:V:Y21	3.52	Yes	Yes	1	8	8
295	V:V:G39	V:V:L22	3.42	No	Yes	1	8	8
296	V:V:F115	V:V:L22	3.65	Yes	Yes	1	9	8
297	V:V:L166	V:V:L22	2.77	Yes	Yes	1	8	8
298	V:V:L166	V:V:R25	6.07	Yes	Yes	1	8	9
299	V:V:I168	V:V:R25	5.01	No	Yes	1	8	9
300	V:V:D26	V:V:R169	15.48	No	Yes	0	9	9
301	V:V:D35	V:V:F27	2.39	No	Yes	0	6	8
302	V:V:F27	V:V:I119	5.02	Yes	Yes	0	8	5
303	V:V:F27	V:V:I168	2.51	Yes	No	0	8	8
304	V:V:F27	V:V:K170	14.89	Yes	Yes	0	8	9
305	V:V:V171	V:V:V28	3.21	No	No	0	6	8
306	V:V:D29	V:V:V34	4.38	No	No	0	9	7
307	V:V:D29	V:V:K170	2.77	No	Yes	0	9	9
308	V:V:H30	V:V:I31	5.3	No	No	0	6	5
309	V:V:H30	V:V:Q172	3.71	No	No	18	6	9
310	V:V:H30	V:V:L305	3.86	No	No	18	6	5
311	V:V:D32	V:V:I31	9.8	No	No	0	4	5
312	V:V:I31	V:V:R307	2.51	No	No	0	5	4
313	V:V:E118	V:V:V34	4.28	No	No	3	4	7
314	V:V:I119	V:V:V34	3.07	Yes	No	3	5	7
315	V:V:D35	V:V:P36	8.05	No	No	0	6	5
316	V:V:F115	V:V:V37	2.62	Yes	No	0	9	8
317	V:V:F117	V:V:V37	7.87	Yes	No	0	8	8
318	V:V:I119	V:V:V37	3.07	Yes	No	0	5	8
319	V:V:D38	V:V:G39	5.03	Yes	No	1	7	8
320	V:V:D38	V:V:T98	4.34	Yes	No	1	7	8
321	V:V:D38	V:V:L100	4.07	Yes	No	1	7	5
322	V:V:D38	V:V:Q101	2.61	Yes	Yes	1	7	9
323	V:V:F115	V:V:G39	4.52	Yes	No	1	9	8
324	V:V:L104	V:V:V40	10.43	No	No	1	9	8
325	V:V:L108	V:V:L42	4.15	Yes	No	1	8	5
326	V:V:H111	V:V:L42	3.86	No	No	0	6	5
327	V:V:A112	V:V:L42	3.15	No	No	1	8	5
328	V:V:V43	V:V:V53	3.21	Yes	Yes	1	6	7
329	V:V:F87	V:V:V43	5.24	Yes	Yes	1	4	6
330	V:V:L48	V:V:R51	12.15	No	No	1	4	6
331	V:V:L48	V:V:V53	2.98	No	Yes	1	4	7
332	V:V:C150	V:V:L48	7.94	Yes	No	1	5	4
333	V:V:E50	V:V:K49	10.8	No	No	0	4	5
334	V:V:C150	V:V:R51	4.18	Yes	No	1	5	6
335	V:V:E152	V:V:R51	12.79	No	No	0	4	6
336	V:V:R52	V:V:Y54	8.23	No	Yes	0	6	4
337	V:V:S86	V:V:V53	3.23	No	Yes	0	6	7
338	V:V:F87	V:V:V53	2.62	Yes	Yes	1	4	7
339	V:V:C150	V:V:V53	3.42	Yes	Yes	1	5	7
340	V:V:N83	V:V:Y54	9.3	No	Yes	0	5	4
341	V:V:Q85	V:V:Y54	11.27	No	Yes	0	9	4
342	V:V:F149	V:V:Y54	4.13	No	Yes	0	5	4
343	V:V:L154	V:V:Y54	5.86	No	Yes	0	3	4
344	V:V:S86	V:V:V55	3.23	No	Yes	0	6	8
345	V:V:F115	V:V:V55	5.24	Yes	Yes	0	9	8
346	V:V:T56	V:V:T58	4.71	Yes	No	7	7	7
347	V:V:N83	V:V:T56	4.39	No	Yes	0	5	7
348	V:V:K147	V:V:T56	3	Yes	Yes	7	7	7
349	V:V:F149	V:V:T56	6.49	No	Yes	7	5	7
350	V:V:F117	V:V:L57	15.83	Yes	No	0	8	7
351	V:V:L57	V:V:V146	4.47	No	No	0	7	6
352	V:V:K147	V:V:T58	3	Yes	No	7	7	7
353	V:V:C59	V:V:Y144	9.41	No	Yes	0	8	7
354	V:V:A60	V:V:R76	6.91	No	No	0	8	8
355	V:V:F61	V:V:G141	4.52	No	No	0	9	9
356	V:V:F61	V:V:V142	2.62	No	No	0	9	9
357	V:V:F61	V:V:I241	3.77	No	No	0	9	8
358	V:V:R62	V:V:T74	23.29	Yes	No	0	8	6
359	V:V:R62	V:V:T136	2.59	Yes	No	0	8	4
360	V:V:K138	V:V:R62	6.19	No	Yes	0	8	8
361	V:V:C140	V:V:R62	5.57	No	Yes	0	9	8
362	V:V:G64	V:V:Y63	2.9	No	Yes	0	9	9
363	V:V:R65	V:V:Y63	4.12	No	Yes	0	7	9
364	V:V:L68	V:V:Y63	3.52	No	Yes	0	7	9
365	V:V:F75	V:V:Y63	13.41	No	Yes	0	9	9
366	V:V:D67	V:V:R65	3.57	No	No	0	9	7
367	V:V:G72	V:V:L68	3.42	No	No	0	9	7
368	V:V:L68	V:V:T74	2.95	No	No	0	7	6
369	V:V:L71	V:V:V70	4.47	No	No	0	7	9
370	V:V:D78	V:V:R76	2.38	No	No	0	8	8
371	V:V:L315	V:V:L79	12.46	No	No	0	5	8
372	V:V:A82	V:V:F80	2.77	No	No	19	4	4
373	V:V:F117	V:V:F80	3.22	Yes	No	19	8	4
374	V:V:A82	V:V:F117	4.16	No	Yes	19	4	8
375	V:V:F87	V:V:P89	5.78	Yes	No	1	4	3
376	V:V:F87	V:V:Y113	8.25	Yes	No	1	4	3
377	V:V:P89	V:V:Y113	19.47	No	No	1	3	3
378	V:V:A90	V:V:E92	3.02	No	No	0	1	3
379	V:V:D93	V:V:K94	2.77	No	No	0	1	3
380	V:V:K94	V:V:T116	9.01	No	No	0	3	4
381	V:V:L97	V:V:Q101	10.65	No	Yes	1	4	9
382	V:V:E102	V:V:L97	2.65	No	No	0	6	4
383	V:V:L97	V:V:P114	3.28	No	Yes	1	4	8
384	V:V:L100	V:V:T98	4.42	No	No	1	5	8
385	V:V:Q101	V:V:T98	8.5	Yes	No	1	9	8
386	V:V:R103	V:V:R99	5.33	No	No	0	6	4
387	V:V:P114	V:V:Q101	6.32	Yes	Yes	1	8	9
388	V:V:Q101	V:V:T116	4.25	Yes	No	0	9	4
389	V:V:K107	V:V:R103	4.95	Yes	No	1	9	6
390	V:V:K107	V:V:L104	14.1	Yes	No	1	9	9
391	V:V:I105	V:V:P114	3.39	No	Yes	0	4	8
392	V:V:K107	V:V:L108	7.05	Yes	Yes	1	9	8
393	V:V:A112	V:V:L108	3.15	No	Yes	1	8	8
394	V:V:P114	V:V:Y113	4.17	Yes	No	1	8	3
395	V:V:F115	V:V:V146	2.62	Yes	No	0	9	6
396	V:V:E118	V:V:I119	2.73	No	Yes	3	4	5
397	V:V:I119	V:V:P120	3.39	Yes	No	3	5	7
398	V:V:I119	V:V:L123	4.28	Yes	Yes	3	5	6
399	V:V:L123	V:V:P120	14.78	Yes	No	3	6	7
400	V:V:N122	V:V:R312	10.85	No	No	0	5	4
401	V:V:L123	V:V:Y144	4.69	Yes	Yes	3	6	7
402	V:V:K170	V:V:L123	5.64	Yes	Yes	3	9	6
403	V:V:P124	V:V:V142	5.3	Yes	No	3	9	9
404	V:V:P124	V:V:Y144	2.78	Yes	Yes	3	9	7
405	V:V:I314	V:V:P124	6.77	No	Yes	0	5	9
406	V:V:G316	V:V:P124	4.06	No	Yes	0	8	9
407	V:V:C125	V:V:K170	4.85	No	Yes	0	7	9
408	V:V:C125	V:V:T304	3.38	No	No	0	7	9
409	V:V:S126	V:V:Y144	3.82	No	Yes	3	9	7
410	V:V:R169	V:V:S126	2.64	Yes	No	0	9	9
411	V:V:K170	V:V:S126	3.06	Yes	No	3	9	9
412	V:V:A301	V:V:V127	3.39	No	No	12	9	8
413	V:V:I317	V:V:V127	10.75	No	No	12	8	8
414	V:V:V127	V:V:V319	3.21	No	Yes	12	8	8
415	V:V:G141	V:V:T128	3.64	No	No	0	9	6
416	V:V:G291	V:V:T128	3.64	No	No	0	9	6
417	V:V:L129	V:V:Q130	2.66	No	Yes	0	8	9
418	V:V:G286	V:V:L129	5.13	No	No	0	9	8
419	V:V:N281	V:V:Q130	6.6	Yes	Yes	6	9	9
420	V:V:K284	V:V:Q130	4.07	Yes	Yes	6	8	9
421	V:V:L287	V:V:Q130	10.65	Yes	Yes	6	7	9
422	V:V:L289	V:V:Q130	2.66	No	Yes	6	9	9
423	V:V:G132	V:V:P133	4.06	No	No	0	6	4
424	V:V:D135	V:V:T136	2.89	No	No	20	8	4
425	V:V:D135	V:V:G137	5.03	No	No	20	8	8
426	V:V:G137	V:V:T136	3.64	No	No	20	8	4
427	V:V:V142	V:V:Y144	5.05	No	Yes	3	9	7
428	V:V:D143	V:V:E145	9.09	No	Yes	0	7	7
429	V:V:K170	V:V:Y144	5.97	Yes	Yes	3	9	7
430	V:V:E145	V:V:K147	8.1	Yes	Yes	7	7	7
431	V:V:E145	V:V:R165	5.82	Yes	No	7	7	5
432	V:V:E145	V:V:V167	4.28	Yes	No	0	7	5
433	V:V:L166	V:V:V146	11.92	Yes	No	0	8	6
434	V:V:F149	V:V:K147	2.48	No	Yes	7	5	7
435	V:V:K147	V:V:R165	3.71	Yes	No	7	7	5
436	V:V:C150	V:V:N162	9.45	Yes	No	0	5	8
437	V:V:A151	V:V:E156	3.02	No	Yes	0	6	6
438	V:V:E152	V:V:E156	5.07	No	Yes	0	4	6
439	V:V:E155	V:V:N153	10.52	No	No	0	4	4
440	V:V:E156	V:V:N153	10.52	Yes	No	0	6	4
441	V:V:E156	V:V:H159	11.08	Yes	No	0	6	5
442	V:V:H159	V:V:I158	3.98	No	No	0	5	5
443	V:V:R165	V:V:S163	3.95	No	No	0	5	8
444	V:V:I168	V:V:L166	7.14	No	Yes	1	8	8
445	V:V:L293	V:V:V167	4.47	No	No	0	8	5
446	V:V:R169	V:V:V171	6.54	Yes	No	0	9	6
447	V:V:D290	V:V:R169	3.57	No	Yes	0	9	9
448	V:V:L293	V:V:R169	4.86	No	Yes	0	8	9
449	V:V:L305	V:V:Q172	2.66	No	No	18	5	9
450	V:V:M352	V:V:Q172	6.8	No	No	0	8	9
451	V:V:A174	V:V:Y173	2.67	No	Yes	0	9	4
452	V:V:E176	V:V:Y173	12.35	No	Yes	0	3	4
453	V:V:P354	V:V:Y173	2.78	No	Yes	0	8	4
454	V:V:K355	V:V:Y173	5.97	No	Yes	21	6	4
455	V:V:P356	V:V:Y173	6.95	No	Yes	21	9	4
456	V:V:A174	V:V:I207	3.25	No	No	0	9	5
457	V:V:I207	V:V:P175	5.08	No	No	0	5	9
458	V:V:I207	V:V:P178	5.08	No	No	0	5	4
459	V:V:G179	V:V:P180	4.06	No	No	22	6	4
460	V:V:E206	V:V:G179	4.91	No	No	22	7	6
461	V:V:E206	V:V:P180	6.29	No	No	22	7	4
462	V:V:L203	V:V:P182	9.85	Yes	No	0	8	9
463	V:V:E206	V:V:P182	9.43	No	No	0	7	9
464	V:V:S202	V:V:T183	3.2	No	No	0	7	4
465	V:V:A184	V:V:L347	4.73	No	No	0	5	6
466	V:V:E185	V:V:E200	16.49	No	No	0	5	7
467	V:V:L199	V:V:T186	2.95	No	No	0	6	7
468	V:V:T186	V:V:V345	6.35	No	No	0	7	7
469	V:V:H198	V:V:T187	15.06	No	No	0	6	5
470	V:V:F190	V:V:R188	12.83	No	No	0	9	8
471	V:V:R188	V:V:V343	3.92	No	No	0	8	7
472	V:V:F190	V:V:K226	2.48	No	Yes	0	9	8
473	V:V:F190	V:V:S341	3.96	No	No	0	9	8
474	V:V:L334	V:V:M192	2.83	No	No	0	3	7
475	V:V:S193	V:V:T224	6.4	No	Yes	23	9	9
476	V:V:K226	V:V:S193	3.06	Yes	No	23	8	9
477	V:V:D194	V:V:K195	4.15	No	No	0	6	7
478	V:V:K195	V:V:N223	15.39	No	No	0	7	6
479	V:V:K195	V:V:T224	7.51	No	Yes	0	7	9
480	V:V:H198	V:V:P196	6.1	No	No	0	6	6
481	V:V:N223	V:V:P196	3.26	No	No	0	6	6
482	V:V:L197	V:V:N222	2.75	No	No	0	7	9
483	V:V:L197	V:V:L327	2.77	No	Yes	0	7	7
484	V:V:L197	V:V:V329	4.47	No	No	0	7	6
485	V:V:H198	V:V:T221	2.74	No	No	0	6	5
486	V:V:L199	V:V:V325	5.96	No	Yes	0	6	8
487	V:V:L199	V:V:L327	4.15	No	Yes	0	6	7
488	V:V:E200	V:V:H219	13.54	No	Yes	0	7	5
489	V:V:A201	V:V:V325	3.39	No	Yes	0	7	8
490	V:V:N217	V:V:S202	5.96	No	No	0	6	7
491	V:V:I214	V:V:L203	2.85	No	Yes	0	8	8
492	V:V:L203	V:V:V216	2.98	Yes	No	0	8	7
493	V:V:F349	V:V:L203	12.18	No	Yes	0	7	8
494	V:V:D204	V:V:K205	16.59	No	No	0	6	8
495	V:V:E212	V:V:Y208	3.37	No	Yes	0	8	6
496	V:V:I214	V:V:Y208	7.25	No	Yes	0	8	6
497	V:V:F349	V:V:Y208	11.35	No	Yes	0	7	6
498	V:V:L351	V:V:Y208	9.38	No	Yes	0	8	6
499	V:V:H210	V:V:N299	5.1	No	No	0	9	8
500	V:V:H210	V:V:H353	3.58	No	No	0	9	8
501	V:V:H210	V:V:P354	3.05	No	No	0	9	8
502	V:V:E212	V:V:P213	9.43	No	No	0	8	4
503	V:V:I214	V:V:L274	4.28	No	No	0	8	5
504	V:V:S215	V:V:T273	4.8	No	No	0	4	3
505	V:V:V216	V:V:V218	3.21	No	No	0	7	7
506	V:V:I233	V:V:V216	3.07	Yes	No	0	5	7
507	V:V:C269	V:V:N217	3.15	No	No	0	5	6
508	V:V:V218	V:V:V325	3.21	No	Yes	0	7	8
509	V:V:H219	V:V:T221	2.74	Yes	No	24	5	5
510	V:V:H219	V:V:T267	2.74	Yes	No	24	5	6
511	V:V:C269	V:V:H219	5.9	No	Yes	0	5	5
512	V:V:L327	V:V:V220	2.98	Yes	No	0	7	6
513	V:V:T221	V:V:T267	3.14	No	No	24	5	6
514	V:V:N222	V:V:T224	5.85	No	Yes	0	9	9
515	V:V:K226	V:V:T224	10.51	Yes	Yes	23	8	9
516	V:V:N225	V:V:P264	3.26	No	No	0	5	5
517	V:V:N225	V:V:R331	3.62	No	No	0	5	5
518	V:V:K226	V:V:R331	2.48	Yes	No	0	8	5
519	V:V:P264	V:V:T227	3.5	No	No	0	5	5
520	V:V:V228	V:V:V262	8.02	No	No	0	8	7
521	V:V:L327	V:V:V228	10.43	Yes	No	0	7	8
522	V:V:V228	V:V:V329	4.81	No	No	0	8	6
523	V:V:K229	V:V:K230	4.31	No	No	0	8	5
524	V:V:K229	V:V:S330	10.71	No	No	0	8	6
525	V:V:E257	V:V:K230	5.4	No	No	0	6	5
526	V:V:D259	V:V:K230	2.77	No	No	0	3	5
527	V:V:A258	V:V:I231	3.25	No	Yes	26	5	6
528	V:V:I231	V:V:Y272	2.42	Yes	No	26	6	4
529	V:V:I231	V:V:V325	3.07	Yes	Yes	0	6	8
530	V:V:I231	V:V:L327	2.85	Yes	Yes	0	6	7
531	V:V:K232	V:V:S234	4.59	Yes	No	2	6	5
532	V:V:K232	V:V:R236	2.48	Yes	Yes	2	6	5
533	V:V:K232	V:V:K324	4.31	Yes	Yes	2	6	6
534	V:V:K232	V:V:K326	11.49	Yes	Yes	2	6	7
535	V:V:E256	V:V:I233	2.73	No	Yes	25	4	5
536	V:V:I233	V:V:L274	14.27	Yes	No	25	5	5
537	V:V:I233	V:V:V323	3.07	Yes	No	0	5	7
538	V:V:R236	V:V:S234	13.18	Yes	No	2	5	5
539	V:V:A254	V:V:V235	3.39	No	No	0	7	8
540	V:V:V235	V:V:V323	3.21	No	No	0	8	7
541	V:V:R236	V:V:Y238	8.23	Yes	Yes	2	5	4
542	V:V:K250	V:V:R236	8.66	No	Yes	2	5	5
543	V:V:K324	V:V:R236	8.66	Yes	Yes	2	6	5
544	V:V:A239	V:V:Q237	6.06	No	Yes	0	8	9
545	V:V:C251	V:V:Q237	12.21	Yes	Yes	6	6	9
546	V:V:L287	V:V:Q237	3.99	Yes	Yes	6	7	9
547	V:V:Q237	V:V:Y321	3.38	Yes	Yes	0	9	9
548	V:V:Q248	V:V:Y238	4.51	No	Yes	0	6	4
549	V:V:K250	V:V:Y238	2.39	No	Yes	2	5	4
550	V:V:K322	V:V:Y238	13.14	No	Yes	2	5	4
551	V:V:E346	V:V:Y238	11.22	No	Yes	2	8	4
552	V:V:D240	V:V:Q248	7.83	No	No	0	6	6
553	V:V:F244	V:V:I241	10.05	No	No	0	8	8
554	V:V:C242	V:V:E313	12.15	No	No	0	6	7
555	V:V:L243	V:V:L315	12.46	No	No	0	7	5
556	V:V:F244	V:V:N245	10.87	No	No	0	8	8
557	V:V:N245	V:V:T246	2.92	No	No	0	8	7
558	V:V:C251	V:V:P252	3.77	Yes	No	0	6	4
559	V:V:C251	V:V:L287	6.35	Yes	Yes	6	6	7
560	V:V:K284	V:V:P252	8.36	Yes	No	0	8	4
561	V:V:E256	V:V:L274	5.3	No	No	25	4	5
562	V:V:A258	V:V:Y272	5.34	No	No	26	5	4
563	V:V:D260	V:V:F268	10.75	No	No	0	6	5
564	V:V:F268	V:V:V262	5.24	No	No	0	5	7
565	V:V:A263	V:V:S266	3.42	No	No	0	4	6
566	V:V:F268	V:V:K270	6.2	No	No	0	5	8
567	V:V:K270	V:V:Y272	4.78	No	No	0	8	4
568	V:V:P276	V:V:T275	3.5	No	No	0	9	4
569	V:V:F277	V:V:T275	3.89	No	No	0	3	4
570	V:V:C279	V:V:F277	2.79	No	No	0	4	3
571	V:V:L278	V:V:L300	5.54	No	No	0	8	9
572	V:V:N280	V:V:N281	5.45	No	Yes	0	4	9
573	V:V:K284	V:V:N281	12.59	Yes	Yes	6	8	9
574	V:V:L287	V:V:N281	9.61	Yes	Yes	6	7	9
575	V:V:L287	V:V:L289	5.54	Yes	No	6	7	9
576	V:V:A288	V:V:I317	3.25	No	No	0	9	8
577	V:V:L289	V:V:T298	4.42	No	No	0	9	8
578	V:V:D290	V:V:G291	6.71	No	No	0	9	9
579	V:V:D290	V:V:T298	5.78	No	No	0	9	8
580	V:V:K292	V:V:L293	4.23	No	No	0	6	8
581	V:V:E296	V:V:K292	5.4	No	No	0	7	6
582	V:V:E296	V:V:K294	9.45	No	No	0	7	9
583	V:V:A301	V:V:V319	3.39	No	Yes	12	9	8
584	V:V:M352	V:V:S302	9.2	No	No	0	8	9
585	V:V:H353	V:V:S302	9.76	No	No	0	8	9
586	V:V:S303	V:V:Y321	5.09	No	Yes	0	8	9
587	V:V:S303	V:V:T350	4.8	No	No	0	8	4
588	V:V:L306	V:V:T304	4.42	No	No	0	4	9
589	V:V:G309	V:V:R307	7.51	No	No	0	4	4
590	V:V:A310	V:V:R307	2.77	No	No	0	4	4
591	V:V:A310	V:V:R312	6.91	No	No	0	4	4
592	V:V:I314	V:V:I318	13.25	No	No	0	5	5
593	V:V:I317	V:V:V319	3.07	No	Yes	12	8	8
594	V:V:V319	V:V:Y321	5.05	Yes	Yes	0	8	9
595	V:V:L351	V:V:Y321	2.34	No	Yes	0	8	9
596	V:V:E346	V:V:K322	14.85	No	No	2	8	5
597	V:V:K322	V:V:P348	5.02	No	No	0	5	9
598	V:V:L347	V:V:V323	2.98	No	No	0	6	7
599	V:V:K324	V:V:K326	12.93	Yes	Yes	2	6	7
600	V:V:A344	V:V:K324	6.42	No	Yes	2	4	6
601	V:V:E346	V:V:K324	16.2	No	Yes	2	8	6
602	V:V:D342	V:V:K326	6.91	No	Yes	2	7	7
603	V:V:A344	V:V:K326	6.42	No	Yes	2	4	7
604	V:V:S340	V:V:V328	3.23	No	No	2	4	4
605	V:V:D342	V:V:V328	7.3	No	No	2	7	4
606	V:V:S341	V:V:V329	3.23	No	No	0	8	6
607	V:V:S330	V:V:S340	3.26	No	No	0	6	4
608	V:V:A339	V:V:L335	4.73	No	No	0	4	4
609	V:V:D337	V:V:L338	10.86	No	No	0	5	4
610	V:V:D342	V:V:S340	2.94	No	No	2	7	4
611	V:V:K355	V:V:P356	3.35	No	No	21	6	9
612	V:V:E283	V:V:R282	2.33	No	No	0	5	6
613	R:R:D340	R:R:Y339	2.3	No	Yes	0	1	2
614	R:R:D340	R:R:Y344	2.3	No	No	0	1	1
615	V:V:E212	V:V:Y209	2.24	No	No	0	8	6
616	R:R:H132	R:R:W129	2.12	No	No	0	4	5
617	R:R:G220	R:R:G221	2.11	No	No	0	5	2
618	V:V:G332	V:V:G333	2.11	No	No	0	5	7
619	V:V:G132	V:V:P131	2.03	No	No	0	6	8
620	R:R:A109	R:R:G106	1.95	No	No	0	9	6
621	R:R:A139	R:R:G140	1.95	No	No	0	1	6
622	V:V:P88	V:V:P89	1.95	No	No	0	9	3
623	V:V:P120	V:V:P121	1.95	No	No	0	7	4
624	V:V:A339	V:V:G336	1.95	No	No	0	4	5
625	R:R:A49	R:R:P50	1.87	No	No	0	6	4
626	R:R:A156	R:R:P248	1.87	No	No	0	8	9
627	V:V:A90	V:V:P91	1.87	No	No	0	1	3
628	V:V:A254	V:V:P276	1.87	No	No	0	7	9
629	V:V:A263	V:V:P264	1.87	No	No	0	4	5
630	V:V:G16	V:V:S13	1.86	No	No	0	5	8
631	V:V:G332	V:V:S330	1.86	No	No	0	5	6
632	R:R:G208	R:R:T227	1.82	No	No	0	4	3
633	R:R:A150	R:R:A200	1.79	No	No	0	6	7
634	V:V:P14	V:V:S13	1.78	No	No	0	6	8
635	V:V:P276	V:V:V253	1.77	No	No	0	9	9
636	R:R:G208	R:R:M207	1.75	No	Yes	0	4	6
637	R:R:P336	R:R:T335	1.75	No	No	0	4	4
638	V:V:P213	V:V:T273	1.75	No	No	0	4	3
639	R:R:A214	R:R:S52	1.71	No	No	0	1	6
640	R:R:G221	R:R:L54	1.71	No	No	0	2	5
641	R:R:G77	R:R:L116	1.71	No	Yes	0	8	7
642	R:R:A154	R:R:S111	1.71	No	No	0	7	8
643	R:R:G301	R:R:L305	1.71	No	Yes	0	8	8
644	R:R:C315	R:R:V314	1.71	Yes	No	0	9	6
645	R:R:C315	R:R:V355	1.71	Yes	No	0	9	5
646	V:V:G23	V:V:L22	1.71	No	Yes	0	8	8
647	V:V:G316	V:V:L315	1.71	No	No	0	8	5
648	R:R:A160	R:R:V251	1.7	No	No	0	8	6
649	R:R:G216	R:R:N211	1.7	No	No	0	2	2
650	V:V:A148	V:V:V20	1.7	No	No	1	6	6
651	V:V:A148	V:V:V41	1.7	No	No	1	6	5
652	V:V:A148	V:V:V55	1.7	No	Yes	0	6	8
653	V:V:C81	V:V:T56	1.69	No	Yes	7	4	7
654	V:V:C81	V:V:T58	1.69	No	No	7	4	7
655	R:R:D215	R:R:G216	1.68	Yes	No	0	2	2
656	V:V:D69	V:V:G64	1.68	No	No	0	9	9
657	V:V:K160	V:V:P14	1.67	No	No	0	8	6
658	V:V:K95	V:V:P96	1.67	No	No	0	3	3
659	V:V:K250	V:V:P252	1.67	No	No	0	5	4
660	R:R:L54	R:R:P133	1.64	No	No	0	5	5
661	V:V:E110	V:V:G109	1.64	No	No	0	3	9
662	V:V:E308	V:V:G309	1.64	No	No	0	3	4
663	R:R:S163	R:R:V159	1.62	No	No	0	9	8
664	R:R:C327	R:R:K234	1.62	No	No	0	3	4
665	R:R:S253	R:R:V309	1.62	No	No	0	5	8
666	R:R:A307	R:R:I310	1.62	No	No	0	7	5
667	R:R:A311	R:R:I310	1.62	No	No	0	7	5
668	R:R:S368	V:V:V70	1.62	No	No	0	8	9
669	R:R:A377	R:R:I374	1.62	No	Yes	0	4	6
670	V:V:S215	V:V:V271	1.62	No	No	0	4	5
671	R:R:A231	R:R:K234	1.61	No	No	0	1	4
672	V:V:D44	V:V:P45	1.61	No	No	0	8	4
673	R:R:V75	R:R:V79	1.6	No	No	0	5	5
674	R:R:V250	R:R:V254	1.6	No	No	0	3	5
675	R:R:V304	R:R:V308	1.6	No	No	0	8	8
676	V:V:V55	V:V:V84	1.6	Yes	No	0	8	3
677	R:R:T264	R:R:V302	1.59	No	No	0	5	7
678	R:R:A72	R:R:L73	1.58	No	No	0	4	7
679	R:R:A219	R:R:L222	1.58	No	No	0	1	4
680	R:R:A260	R:R:L305	1.58	No	Yes	0	6	8
681	V:V:P131	V:V:Q130	1.58	No	Yes	0	8	9
682	V:V:P182	V:V:Q181	1.58	No	No	0	9	7
683	V:V:E283	V:V:P133	1.57	No	No	0	5	4
684	V:V:T227	V:V:T261	1.57	No	No	0	5	5
685	V:V:C242	V:V:D240	1.56	No	No	0	6	6
686	V:V:A247	V:V:N245	1.56	No	No	0	8	8
687	R:R:I60	R:R:V64	1.54	No	No	0	2	6
688	R:R:I246	R:R:V250	1.54	No	No	0	5	3
689	V:V:A60	V:V:D143	1.54	No	No	0	8	7
690	R:R:H172	R:R:P173	1.53	No	No	0	6	8
691	V:V:M352	V:V:S303	1.53	No	No	0	8	8
692	R:R:K234	R:R:V235	1.52	No	No	0	4	4
693	V:V:A90	V:V:Q85	1.52	No	No	0	1	9
694	R:R:F136	R:R:G137	1.51	No	No	0	7	8
695	R:R:F146	R:R:G143	1.51	No	No	0	6	5
696	R:R:L54	R:R:S51	1.5	No	No	0	5	3
697	R:R:L94	R:R:S93	1.5	No	No	0	5	6
698	R:R:L162	R:R:S163	1.5	No	No	0	9	9
699	R:R:G293	R:R:R294	1.5	No	No	0	3	4
700	R:R:L198	R:R:V201	1.49	No	No	0	4	5
701	R:R:L298	R:R:V302	1.49	No	No	0	7	7
702	V:V:L300	V:V:V253	1.49	No	No	0	9	9
703	R:R:L179	R:R:T178	1.47	No	No	0	4	4
704	R:R:D331	R:R:S330	1.47	No	No	0	1	2
705	R:R:N256	R:R:T257	1.46	No	No	0	9	3
706	R:R:A369	R:R:H373	1.46	No	No	0	4	4
707	R:R:P173	V:V:F75	1.44	No	No	0	8	9
708	R:R:F247	R:R:P248	1.44	No	No	0	6	9
709	R:R:Q333	R:R:S330	1.44	No	No	0	1	2
710	V:V:P178	V:V:R177	1.44	No	No	0	4	3
711	R:R:Q269	R:R:V265	1.43	No	No	0	7	4
712	V:V:K77	V:V:L243	1.41	No	No	0	9	7
713	R:R:A191	R:R:F188	1.39	No	No	0	4	6
714	R:R:L113	R:R:L117	1.38	No	No	0	7	5
715	R:R:L118	R:R:L147	1.38	No	No	0	5	5
716	R:R:A307	R:R:R303	1.38	No	No	0	7	7
717	R:R:L363	R:R:L366	1.38	No	No	0	8	6
718	R:R:A369	R:R:R372	1.38	No	No	0	4	9
719	R:R:L379	R:R:L382	1.38	No	No	0	7	3
720	R:R:I329	R:R:Q333	1.37	Yes	No	0	3	1
721	V:V:D32	V:V:L33	1.36	No	No	0	4	3
722	V:V:D297	V:V:N299	1.35	No	No	0	8	8
723	R:R:A195	R:R:Y153	1.33	No	Yes	0	5	7
724	R:R:R184	R:R:S181	1.32	No	No	0	5	8
725	R:R:D215	R:R:Q217	1.31	Yes	No	0	2	1
726	R:R:F345	R:R:V321	1.31	No	No	0	4	5
727	R:R:F345	R:R:V348	1.31	No	No	0	4	6
728	R:R:V64	R:R:Y61	1.26	No	No	0	6	2
729	R:R:V69	R:R:Y354	1.26	No	Yes	0	4	7
730	R:R:R294	V:V:L73	1.21	No	No	0	4	8
731	R:R:L376	R:R:R372	1.21	No	No	0	4	9
732	V:V:L334	V:V:R331	1.21	No	No	0	3	5
733	R:R:D59	R:R:Y61	1.15	No	No	0	3	2
734	V:V:D44	V:V:Y47	1.15	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P2	7.895	4	5	0
2	R:R:Y70	11.5975	4	9	7
3	R:R:L88	6.4625	4	15	7
4	R:R:Q95	5.198	5	0	4
5	R:R:Q98	6.55	4	0	7
6	R:R:H104	3.6325	4	0	8
7	R:R:T115	4.4225	4	14	7
8	R:R:L116	3.736	5	14	7
9	R:R:M120	8.3075	4	9	8
10	R:R:W134	6.904	5	8	8
11	R:R:C141	6.1125	4	8	9
12	R:R:Y145	4.33	4	8	4
13	R:R:R148	5.53	5	0	7
14	R:R:Y153	7.23	4	10	7
15	R:R:Y167	10.43	4	0	8
16	R:R:I170	6.275	4	17	9
17	R:R:I189	8.958	5	16	7
18	R:R:M207	3.63333	6	8	6
19	R:R:D215	2.4975	4	13	2
20	R:R:I228	6.415	4	0	5
21	R:R:F245	5.504	5	4	8
22	R:R:I259	5.144	5	17	9
23	R:R:L305	4.295	4	0	8
24	R:R:C315	2.872	5	4	9
25	R:R:W316	12.166	5	4	8
26	R:R:L317	5.785	4	4	7
27	R:R:H320	7.302	5	4	7
28	R:R:R323	8.2125	4	0	6
29	R:R:I329	12.7675	4	0	3
30	R:R:W334	13.57	5	5	4
31	R:R:L338	6.7825	4	5	1
32	R:R:Y339	4.785	4	5	2
33	R:R:Y342	6.225	4	0	4
34	R:R:F353	8.015	4	0	7
35	R:R:Y354	11.045	4	9	7
36	R:R:F371	8.134	5	11	8
37	R:R:I374	3.958	5	11	6
38	V:V:K17	6.7525	4	1	5
39	V:V:L18	4.708	5	1	6
40	V:V:Y21	5.828	5	1	8
41	V:V:L22	2.8875	4	1	8
42	V:V:R25	5.592	5	1	9
43	V:V:F27	6.2025	4	0	8
44	V:V:D38	4.0125	4	1	7
45	V:V:V43	4.7475	4	1	6
46	V:V:V53	3.092	5	1	7
47	V:V:Y54	7.758	5	0	4
48	V:V:V55	2.9425	4	0	8
49	V:V:T56	4.056	5	7	7
50	V:V:R62	9.41	4	0	8
51	V:V:Y63	5.9875	4	0	9
52	V:V:F87	5.4725	4	1	4
53	V:V:Q101	6.466	5	1	9
54	V:V:K107	7.2	4	1	9
55	V:V:L108	4.4675	4	1	8
56	V:V:P114	4.29	4	1	8
57	V:V:F115	3.73	5	1	9
58	V:V:F117	7.77	4	19	8
59	V:V:I119	3.59333	6	3	5
60	V:V:L123	7.3475	4	3	6
61	V:V:P124	4.7275	4	3	9
62	V:V:Q130	4.70333	6	6	9
63	V:V:Y144	5.28667	6	3	7
64	V:V:E145	6.8225	4	7	7
65	V:V:K147	4.058	5	7	7
66	V:V:C150	6.2475	4	1	5
67	V:V:E156	7.4225	4	0	6
68	V:V:L166	6.975	4	1	8
69	V:V:R169	6.618	5	0	9
70	V:V:K170	6.19667	6	3	9
71	V:V:Y173	6.144	5	21	4
72	V:V:L203	6.965	4	0	8
73	V:V:Y208	7.8375	4	0	6
74	V:V:H219	6.23	4	24	5
75	V:V:T224	7.5675	4	23	9
76	V:V:K226	4.6325	4	23	8
77	V:V:I231	2.8975	4	26	6
78	V:V:K232	5.7175	4	2	6
79	V:V:I233	5.785	4	25	5
80	V:V:R236	8.242	5	2	5
81	V:V:Q237	6.41	4	6	9
82	V:V:Y238	7.898	5	2	4
83	V:V:C251	6.345	4	6	6
84	V:V:N281	8.5625	4	6	9
85	V:V:K284	6.9325	4	6	8
86	V:V:L287	7.228	5	6	7
87	V:V:V319	3.68	4	12	8
88	V:V:Y321	3.965	4	0	9
89	V:V:K324	9.704	5	2	6
90	V:V:V325	3.9075	4	0	8
91	V:V:K326	9.4375	4	2	7
92	V:V:L327	4.636	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	R:R:Y342	14.9402	4.17	Yes	Yes	0	0	4
2	L:L:P2	R:R:Y339	12.5729	4.17	Yes	Yes	5	0	2
3	R:R:D340	R:R:Y339	11.4959	2.3	No	Yes	0	1	2
4	R:R:D340	R:R:Y344	10.78	2.3	No	No	0	1	1
5	R:R:M347	R:R:Y344	10.0684	2.39	No	No	0	3	1
6	R:R:F127	R:R:K63	16.7893	13.65	No	No	0	4	5
7	R:R:I128	R:R:K63	15.4019	10.18	No	No	0	4	5
8	R:R:I128	R:R:W129	14.7074	12.92	No	No	0	4	5
9	R:R:H132	R:R:W129	13.3169	2.12	No	No	0	4	5
10	R:R:G220	R:R:H132	12.6208	9.53	No	No	0	5	4
11	R:R:M120	R:R:Y70	12.1804	8.38	Yes	Yes	9	8	7
12	R:R:R322	R:R:Y342	24.3719	9.26	No	Yes	0	5	4
13	R:R:R322	R:R:Y346	24.1255	17.49	No	No	0	5	4
14	R:R:T349	R:R:Y346	24.4382	2.5	No	No	0	6	4
15	R:R:F353	R:R:T349	24.9275	2.59	Yes	No	0	7	6
16	R:R:F353	R:R:R148	30.3571	3.21	Yes	Yes	0	7	7
17	R:R:R148	R:R:T115	17.7863	6.47	Yes	Yes	0	7	7
18	R:R:L116	R:R:T115	16.4188	2.95	Yes	Yes	14	7	7
19	R:R:F74	R:R:L116	13.9589	2.44	No	Yes	0	7	7
20	R:R:F74	R:R:M120	13.25	7.46	No	Yes	0	7	8
21	R:R:F353	R:R:W316	55.3303	19.04	Yes	Yes	0	7	8
22	R:R:F312	R:R:W316	68.6146	20.04	No	Yes	0	9	8
23	R:R:F312	R:R:V159	68.8759	5.24	No	No	0	9	8
24	R:R:S163	R:R:V159	69.1368	1.62	No	No	0	9	8
25	R:R:I252	R:R:S163	69.6568	4.64	No	No	0	8	9
26	R:R:I252	R:R:V308	69.9161	3.07	No	No	0	8	8
27	R:R:V304	R:R:V308	70.1747	1.6	No	No	0	8	8
28	R:R:V304	R:R:V367	70.4329	3.21	No	No	0	8	7
29	R:R:V367	R:R:Y364	70.6905	2.52	No	No	0	7	9
30	R:R:L105	R:R:Y364	74.9882	12.89	No	No	0	8	9
31	R:R:L105	R:R:V101	35.9584	5.96	No	No	0	8	8
32	R:R:Q98	R:R:V101	35.6366	4.3	Yes	No	0	7	8
33	R:R:Q98	R:R:T100	11.8905	8.5	Yes	No	0	7	7
34	R:R:T100	R:R:T185	11.5328	9.42	No	No	0	7	7
35	R:R:L105	R:R:L88	97.9136	4.15	No	Yes	0	8	7
36	R:R:K91	R:R:L88	98.5867	8.46	No	Yes	15	5	7
37	R:R:K91	R:R:L97	99.0597	5.64	No	No	0	5	8
38	R:R:L94	R:R:L97	99.4374	6.92	No	No	0	5	8
39	R:R:L94	V:V:R285	99.813	10.93	No	No	0	5	7
40	R:R:Q95	V:V:R285	100	3.5	Yes	No	0	4	7
41	R:R:Q95	V:V:C251	63.0777	3.05	Yes	Yes	0	4	6
42	R:R:Q95	V:V:K284	37.5293	2.71	Yes	Yes	0	4	8
43	R:R:Q98	V:V:R65	23.4465	10.51	Yes	No	0	7	7
44	R:R:R148	R:R:Y144	12.7393	11.32	Yes	No	0	7	6
45	R:R:V122	R:R:W134	11.1946	2.45	No	Yes	0	6	8
46	V:V:R65	V:V:Y63	22.7675	4.12	No	Yes	0	7	9
47	V:V:F75	V:V:Y63	18.6649	13.41	No	Yes	0	9	9
48	R:R:M266	V:V:F75	15.9019	2.49	No	No	0	6	9
49	R:R:K262	R:R:M266	14.1697	12.96	No	No	0	5	6
50	R:R:I170	R:R:K262	12.7808	8.72	Yes	No	0	9	5
51	V:V:C251	V:V:L287	36.6545	6.35	Yes	Yes	6	6	7
52	V:V:L287	V:V:L289	62.0191	5.54	Yes	No	6	7	9
53	V:V:L289	V:V:T298	99.2919	4.42	No	No	0	9	8
54	V:V:D290	V:V:T298	99.095	5.78	No	No	0	9	8
55	V:V:D290	V:V:R169	96.4099	3.57	No	Yes	0	9	9
56	V:V:R169	V:V:S126	90.19	2.64	Yes	No	0	9	9
57	V:V:K170	V:V:S126	65.212	3.06	Yes	No	3	9	9
58	V:V:F27	V:V:K170	42.0097	14.89	Yes	Yes	0	8	9
59	V:V:F27	V:V:I168	20.5667	2.51	Yes	No	0	8	8
60	V:V:K284	V:V:Q130	37.265	4.07	Yes	Yes	6	8	9
61	V:V:L289	V:V:Q130	37.4688	2.66	No	Yes	6	9	9
62	V:V:S126	V:V:Y144	24.7627	3.82	No	Yes	3	9	7
63	V:V:L123	V:V:Y144	21.8545	4.69	Yes	Yes	3	6	7
64	V:V:I119	V:V:L123	41.5951	4.28	Yes	Yes	3	5	6
65	V:V:I119	V:V:V37	60.5954	3.07	Yes	No	0	5	8
66	V:V:F115	V:V:V37	56.1725	2.62	Yes	No	0	9	8
67	V:V:F115	V:V:G39	30.0893	4.52	Yes	No	1	9	8
68	V:V:D38	V:V:G39	38.8784	5.03	Yes	No	1	7	8
69	V:V:D38	V:V:L100	25.8365	4.07	Yes	No	1	7	5
70	R:R:E415	V:V:L100	24.8684	2.65	No	No	1	6	5
71	R:R:E415	V:V:K107	21.1426	2.7	No	Yes	1	6	9
72	V:V:K170	V:V:L123	21.5214	5.64	Yes	Yes	3	9	6
73	V:V:F27	V:V:I119	20.7087	5.02	Yes	Yes	0	8	5
74	V:V:I168	V:V:L166	11.7374	7.14	No	Yes	1	8	8
75	V:V:L166	V:V:L22	10.9244	2.77	Yes	Yes	1	8	8
76	V:V:K107	V:V:L108	11.2013	7.05	Yes	Yes	1	9	8
77	V:V:F115	V:V:V55	25.7274	5.24	Yes	Yes	0	9	8
78	V:V:C251	V:V:Q237	29.1399	12.21	Yes	Yes	6	6	9
79	V:V:Q237	V:V:Y321	54.9531	3.38	Yes	Yes	0	9	9
80	V:V:D38	V:V:Q101	11.1601	2.61	Yes	Yes	1	7	9
81	V:V:S86	V:V:V55	21.9966	3.23	No	Yes	0	6	8
82	V:V:S86	V:V:V53	21.0894	3.23	No	Yes	0	6	7
83	V:V:E152	V:V:R51	13.1326	12.79	No	No	0	4	6
84	V:V:E152	V:V:E156	11.258	5.07	No	Yes	0	4	6
85	V:V:L351	V:V:Y321	49.9163	2.34	No	Yes	0	8	9
86	V:V:L351	V:V:Y208	49.7665	9.38	No	Yes	0	8	6
87	V:V:I214	V:V:Y208	25.9612	7.25	No	Yes	0	8	6
88	V:V:I214	V:V:L203	22.5597	2.85	No	Yes	0	8	8
89	V:V:F349	V:V:Y208	22.7429	11.35	No	Yes	0	7	6
90	V:V:F349	V:V:L203	22.5602	12.18	No	Yes	0	7	8
91	V:V:L203	V:V:V216	42.7189	2.98	Yes	No	0	8	7
92	V:V:V216	V:V:V218	42.6809	3.21	No	No	0	7	7
93	V:V:V218	V:V:V325	42.2714	3.21	No	Yes	0	7	8
94	V:V:L199	V:V:V325	20.0739	5.96	No	Yes	0	6	8
95	V:V:L199	V:V:L327	18.801	4.15	No	Yes	0	6	7
96	V:V:L197	V:V:L327	29.7707	2.77	No	Yes	0	7	7
97	V:V:L197	V:V:N222	24.5524	2.75	No	No	0	7	9
98	V:V:N222	V:V:T224	23.6825	5.85	No	Yes	0	9	9
99	V:V:K195	V:V:T224	13.2339	7.51	No	Yes	0	7	9
100	V:V:K195	V:V:N223	11.4763	15.39	No	No	0	7	6
101	V:V:N223	V:V:P196	10.5967	3.26	No	No	0	6	6
102	V:V:I231	V:V:V325	21.3829	3.07	Yes	Yes	0	6	8
103	V:V:I231	V:V:L327	18.8074	2.85	Yes	Yes	0	6	7
104	V:V:K250	V:V:P252	16.3099	1.67	No	No	0	5	4
105	V:V:K250	V:V:R236	12.2406	8.66	No	Yes	2	5	5
106	R:R:V122	R:R:Y144	11.4913	20.19	No	No	0	6	6
107	V:V:L287	V:V:Q237	26.0725	3.99	Yes	Yes	6	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R1	R:R:W334	12	5	No	Yes	0	4	0	1
L:L:P2	R:R:W334	18.92	5	Yes	Yes	0	4	0	1
L:L:P2	R:R:Y339	4.17	5	Yes	Yes	0	2	0	1
L:L:P2	R:R:Y342	4.17	5	Yes	Yes	0	4	0	1
L:L:Y3	R:R:R212	18.52	0	No	No	0	1	0	1
L:L:I4	R:R:V223	3.07	0	No	No	0	4	0	1
L:L:L5	R:R:M207	5.65	0	No	Yes	0	6	0	1
L:L:L5	R:R:P226	6.57	0	No	No	0	5	0	1
L:L:L5	R:R:F326	3.65	0	No	No	0	4	0	1
R:R:V56	R:R:Y339	5.05	5	No	Yes	2	2	2	1
R:R:H343	R:R:V56	19.37	5	No	No	4	2	2	2
R:R:C141	R:R:Y145	2.69	8	Yes	Yes	9	4	2	2
R:R:C141	R:R:M207	3.24	8	Yes	Yes	9	6	2	1
R:R:C141	R:R:C224	5.46	8	Yes	No	9	9	2	2
R:R:M203	R:R:Y145	7.18	8	No	Yes	5	4	2	2
R:R:M207	R:R:Y145	3.59	8	Yes	Yes	6	4	1	2
R:R:M203	R:R:M207	4.33	8	No	Yes	5	6	2	1
R:R:C224	R:R:M207	3.24	8	No	Yes	9	6	2	1
R:R:Q210	R:R:R212	4.67	0	No	No	1	1	2	1
R:R:R212	R:R:V223	2.62	0	No	No	1	4	1	1
R:R:P226	R:R:V233	8.84	0	No	No	5	5	1	2
R:R:R322	R:R:Y342	9.26	0	No	Yes	5	4	2	1
R:R:I329	R:R:M325	5.83	0	Yes	No	3	4	2	2
R:R:L338	R:R:M325	4.24	5	Yes	No	1	4	2	2
R:R:M325	R:R:Y342	8.38	0	No	Yes	4	4	2	1
R:R:F326	R:R:W334	3.01	0	No	Yes	4	4	1	1
R:R:F326	R:R:Y342	3.09	0	No	Yes	4	4	1	1
R:R:I329	R:R:W334	29.36	0	Yes	Yes	3	4	2	1
R:R:L338	R:R:W334	4.56	5	Yes	Yes	1	4	2	1
R:R:H343	R:R:Y339	7.62	5	No	Yes	4	2	2	1
R:R:D340	R:R:Y339	2.3	0	No	Yes	1	2	2	1
R:R:G208	R:R:M207	1.75	0	No	Yes	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
53.85	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
50.00	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
50.00	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
50.00	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
46.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
46.67	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
42.86	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
42.86	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
41.18	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
40.00	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
40.00	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
40.00	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
40.00	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
40.00	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
40.00	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
40.00	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
40.00	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
40.00	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
40.00	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
38.46	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
38.46	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
37.50	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
36.36	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
36.36	Consensus	neurotensin_off	Orthosteric Ligand	nts1_off
36.36	Consensus	nts1_off	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
35.71	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
35.29	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
33.33	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
33.33	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
33.33	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
33.33	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
33.33	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
33.33	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
33.33	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
33.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
33.33	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
33.33	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
31.58	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
31.25	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
31.25	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
31.25	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
31.25	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.77	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
30.00	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
29.41	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
29.41	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
29.41	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
29.41	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
28.57	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
28.57	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
27.78	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
27.27	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
27.27	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
27.27	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
26.67	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
26.67	Single	5N2S	PSB36	5N2S-A₁-PSB36
26.67	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
26.67	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
26.67	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
26.67	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
26.67	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
26.32	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.32	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.09	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
25.00	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
25.00	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
25.00	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
25.00	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
25.00	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
25.00	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
25.00	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
25.00	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
24.00	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
23.81	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
23.81	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
23.81	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
23.81	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53	Single	6OS2	TRV026	6OS2-AT₁-TRV026
23.53	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
23.53	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
23.53	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
23.53	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
23.53	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
23.08	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
23.08	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
23.08	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
23.08	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
23.08	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
23.08	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
23.08	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
23.08	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
23.08	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
23.08	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
23.08	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
23.08	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
23.08	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
23.08	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
23.08	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
23.08	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
22.73	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
22.73	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
22.73	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
22.73	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
22.73	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
22.22	Single	7EZC	UKA	7EZC-A_2A-UKA
22.22	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
22.22	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
22.22	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
22.22	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
22.22	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
22.22	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
22.22	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
22.22	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
22.22	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
22.22	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
22.22	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
22.22	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
22.22	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
22.22	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
21.74	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
21.74	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
21.74	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.74	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
21.74	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
21.43	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
21.43	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
21.43	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
21.43	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
21.43	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
21.43	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
21.43	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
21.43	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
21.43	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
21.43	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.43	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
21.43	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
21.43	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
21.43	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
21.43	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
21.43	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
21.43	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
21.43	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
21.43	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
21.43	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
21.43	Consensus	a2_off	Orthosteric Ligand	a2a_off
21.43	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
21.43	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.43	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
21.05	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
21.05	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
21.05	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
21.05	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
21.05	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
21.05	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05	Single	8XQJ	JN241	8XQJ-Apelin-JN241
21.05	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
21.05	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
21.05	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
21.05	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
21.05	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
21.05	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
21.05	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
20.83	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
20.83	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.83	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
20.83	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.83	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
20.83	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
20.83	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
20.69	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
20.00	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
20.00	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
20.00	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
20.00	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
20.00	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
20.00	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
20.00	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
20.00	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
20.00	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
20.00	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
20.00	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
20.00	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
20.00	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
20.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
20.00	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
20.00	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
20.00	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
20.00	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
20.00	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
20.00	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
20.00	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
20.00	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
20.00	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
20.00	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00	Consensus	a3_on	Orthosteric Ligand	a3a_on
20.00	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
20.00	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
20.00	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
20.00	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
20.00	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
20.00	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
20.00	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
20.00	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
20.00	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
19.23	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
19.23	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
19.23	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.23	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.23	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
19.23	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
19.23	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.05	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
19.05	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
19.05	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.05	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
19.05	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
19.05	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
19.05	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
19.05	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
19.05	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
19.05	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
19.05	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
19.05	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
18.75	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
18.75	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
18.75	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
18.75	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.75	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
18.75	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
18.75	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
18.75	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
18.75	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
18.75	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
18.75	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
18.75	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
18.75	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
18.75	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.75	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
18.75	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
18.75	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
18.75	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
18.75	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
18.75	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.75	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
18.75	Consensus	dp_off	Orthosteric Ligand	dp2_off
18.75	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
18.52	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.52	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.52	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
18.52	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
18.52	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.52	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
18.18	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
18.18	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
18.18	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
18.18	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
18.18	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
18.18	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
18.18	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
18.18	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.18	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
18.18	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
18.18	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
18.18	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
18.18	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
18.18	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
17.65	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
17.65	Single	6OS1	TRV026	6OS1-AT₁-TRV026
17.65	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
17.65	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
17.65	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
17.65	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
17.65	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
17.65	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
17.65	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
17.65	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
17.65	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
17.65	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
17.65	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.65	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
17.65	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
17.65	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
17.39	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
17.39	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
17.39	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.39	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
17.39	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
17.39	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
17.24	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
16.67	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
16.67	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
16.67	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
16.67	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
16.67	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
16.67	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
16.67	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
16.67	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
16.67	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
16.67	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
16.67	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
16.67	Single	7V6A	-	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
16.67	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
16.67	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
16.67	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
16.67	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
16.67	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.67	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
16.67	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
16.67	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
16.67	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
16.67	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
16.67	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
16.67	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
16.67	Single	8XQJ	JN241	8XQJ-Apelin-JN241
16.67	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.67	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
16.67	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
16.67	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
16.67	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
16.67	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
16.67	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.00	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.00	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
16.00	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
16.00	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
16.00	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.00	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.00	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
16.00	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.00	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
16.00	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
16.00	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
16.00	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
16.00	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
16.00	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
16.00	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
15.79	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
15.79	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
15.79	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
15.79	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.79	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
15.79	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
15.79	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
15.38	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
15.38	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
15.38	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
15.38	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
15.38	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
15.38	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
15.38	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
15.38	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
15.38	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
15.38	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
15.38	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
15.38	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
15.38	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
15.38	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
15.38	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
15.38	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
15.38	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
15.38	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.38	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
15.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
15.00	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
15.00	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
15.00	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.00	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
15.00	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
15.00	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
15.00	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
15.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
15.00	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
15.00	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
15.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
15.00	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
15.00	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
15.00	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
15.00	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
15.00	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
15.00	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.00	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.81	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
14.81	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.81	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
14.81	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.81	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
14.81	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
14.81	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
14.81	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
14.81	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
14.29	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
14.29	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
14.29	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
14.29	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
14.29	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
14.29	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
14.29	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
14.29	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
14.29	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
14.29	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
14.29	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
14.29	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
14.29	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
14.29	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
14.29	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
14.29	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
14.29	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
14.29	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
14.29	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
14.29	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.29	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
14.29	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
14.29	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
14.29	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
14.29	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
14.29	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
14.29	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
14.29	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
14.29	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
14.29	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
14.29	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
14.29	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
14.29	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.29	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
14.29	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
14.29	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
14.29	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
14.29	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
14.29	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
14.29	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
14.29	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
14.29	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
14.29	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
14.29	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
14.29	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.29	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.29	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
14.29	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
14.29	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.29	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.29	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
14.29	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
14.29	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
13.79	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
13.79	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
13.79	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
13.79	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
13.79	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
13.64	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
13.64	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
13.64	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
13.64	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
13.64	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
13.64	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
13.64	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
13.64	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
13.64	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
13.64	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
13.64	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
13.64	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
13.64	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
13.64	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
13.33	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
13.33	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
13.33	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
13.33	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
13.33	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
13.33	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
13.33	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
13.33	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
13.33	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
13.33	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
13.33	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
13.33	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
13.33	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
13.33	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
13.33	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
13.33	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
13.33	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.33	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
13.33	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
13.33	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
13.33	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
13.33	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
13.33	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
13.33	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
13.33	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
13.33	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
13.33	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
13.33	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
13.33	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100-Cholesterol
13.33	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
13.33	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
13.33	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
13.33	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
13.33	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
13.33	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
13.33	Consensus	hca_on	Orthosteric Ligand	hca2_on
13.33	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.04	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
13.04	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
13.04	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
13.04	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
13.04	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
13.04	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
13.04	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
13.04	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.04	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
13.04	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
13.04	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
12.90	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
12.90	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
12.50	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
12.50	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
12.50	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
12.50	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
12.50	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
12.50	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
12.50	Single	5UEN	DU172	5UEN-A₁-DU172
12.50	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
12.50	Single	6D27	CAY10471	6D27-DP₂-CAY10471
12.50	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
12.50	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
12.50	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
12.50	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
12.50	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
12.50	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
12.50	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
12.50	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
12.50	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
12.50	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
12.50	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
12.50	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
12.50	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
12.50	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
12.50	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
12.50	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
12.50	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
12.50	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
12.50	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
12.50	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
12.50	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
12.50	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
12.50	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
12.50	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
12.50	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
12.50	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
12.50	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
12.50	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
12.50	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
12.50	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
12.50	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
12.50	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
12.50	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
12.50	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
12.50	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
12.50	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
12.50	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
12.50	Consensus	cck_off	Orthosteric Ligand	ccka_off
12.50	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
12.50	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
12.50	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
12.50	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.50	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
12.50	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
12.50	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
12.50	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
12.50	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
12.50	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
12.50	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
12.00	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
12.00	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.00	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
12.00	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
12.00	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
12.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
12.00	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
12.00	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
12.00	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
12.00	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
12.00	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
12.00	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
11.76	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
11.76	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
11.76	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
11.76	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
11.76	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
11.76	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
11.76	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
11.76	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
11.76	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
11.76	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
11.76	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
11.76	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
11.76	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
11.76	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
11.76	Single	7W41	PD176252	7W41-BB₂-PD176252
11.76	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
11.76	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
11.76	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
11.76	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
11.76	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
11.76	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
11.76	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
11.76	Single	8WGB	W9R	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
11.76	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
11.76	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
11.76	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
11.76	Consensus	blt_off	Orthosteric Ligand	blt1_off
11.76	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
11.76	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
11.76	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
11.76	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
11.76	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.76	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.76	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
11.54	Single	6FJ3	PTH	6FJ3-PTH1-PTH
11.54	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
11.54	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
11.54	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
11.54	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
11.54	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
11.11	Single	2YDV	NECA	2YDV-A_2A-NECA
11.11	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
11.11	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
11.11	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
11.11	Single	5G53	NECA	5G53-A_2A-NECA-Gs
11.11	Single	5V56	TC114	5V56-SMO-TC114
11.11	Single	5V57	TC114	5V57-SMO-TC114
11.11	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
11.11	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
11.11	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
11.11	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
11.11	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
11.11	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
11.11	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
11.11	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
11.11	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
11.11	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
11.11	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.11	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
11.11	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
11.11	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
11.11	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
11.11	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
11.11	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
11.11	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
11.11	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
11.11	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
11.11	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.11	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
11.11	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
11.11	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
11.11	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
11.11	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
11.11	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
11.11	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
11.11	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
11.11	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
11.11	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.11	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
11.11	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
11.11	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
11.11	Consensus	a2_on	Orthosteric Ligand	a2b_on
11.11	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
11.11	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
11.11	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
11.11	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
11.11	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
11.11	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
11.11	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
11.11	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
11.11	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
11.11	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
11.11	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
11.11	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
10.71	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.71	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
10.71	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
10.71	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
10.71	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
10.71	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.71	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
10.71	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
10.53	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
10.53	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
10.53	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
10.53	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
10.53	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
10.53	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.53	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
10.53	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
10.53	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
10.53	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
10.53	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
10.53	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
10.53	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
10.53	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
10.53	Single	8JWY	2-118	8JWY-A_2A-2-118
10.53	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
10.53	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
10.53	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116-Cholesterol
10.53	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
10.53	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
10.53	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
10.53	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
10.53	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
10.53	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.53	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.53	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Consensus	orexin_on	Orthosteric Ligand	ox2_on
10.53	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
10.34	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
10.34	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
10.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
10.00	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
10.00	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
10.00	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
10.00	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
10.00	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
10.00	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
10.00	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
10.00	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
10.00	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
10.00	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
10.00	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
10.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
10.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
10.00	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
10.00	Single	8GEJ	Constrained Epinephrine	8GEJ-β₂-Constrained Epinephrine-Gs/β1/γ2
10.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
10.00	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
10.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
10.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
10.00	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
10.00	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
10.00	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
10.00	Single	8XOF	Lys05	8XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
10.00	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
10.00	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
10.00	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
10.00	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
10.00	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
9.68	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.68	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
9.68	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
9.68	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
9.52	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
9.52	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
9.52	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.52	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
9.52	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
9.52	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
9.52	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
9.52	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
9.38	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.38	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
9.38	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
9.38	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
9.09	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
9.09	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
9.09	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
9.09	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
9.09	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
9.09	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.09	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.09	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/β1/γ2
9.09	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
9.09	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	7XKD	Beta-Hydroxyandrosterone	7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
9.09	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
9.09	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
9.09	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
9.09	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
9.09	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
9.09	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
9.09	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
8.82	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.82	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.70	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
8.70	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.70	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
8.70	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
8.70	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
8.70	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
8.70	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
8.70	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
8.70	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
8.70	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.70	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
8.70	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
8.70	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.57	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
8.33	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
8.33	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
8.33	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
8.33	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
8.33	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
8.33	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.33	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
8.33	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.33	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
8.33	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
8.33	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.33	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.33	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
8.33	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
8.33	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.33	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
8.33	Consensus	sensory_on	Orthosteric Ligand	opsins_on
8.11	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
8.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
8.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
8.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
8.00	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
8.00	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
8.00	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
8.00	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
8.00	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
8.00	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
8.00	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
8.00	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
8.00	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.00	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
8.00	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
7.69	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
7.69	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
7.69	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
7.69	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
7.69	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
7.69	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
7.69	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
7.69	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
7.69	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
7.69	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.69	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
7.69	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
7.69	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
7.69	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69	Single	8GH1	Constrained Epinephrine	8GH1-β₂-Constrained Epinephrine
7.69	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.69	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
7.69	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
7.69	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
7.69	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
7.69	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.69	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.69	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.69	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
7.69	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.69	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
7.50	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.41	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
7.41	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
7.41	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
7.14	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
7.14	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
7.14	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
7.14	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
7.14	Single	6HLL	CP99994	6HLL-NK₁-CP99994
7.14	Single	6LI0	C17	6LI0-GPR52-C17
7.14	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
7.14	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
7.14	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
7.14	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
7.14	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
7.14	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
7.14	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.14	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
7.14	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7.14	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
7.14	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
7.14	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
7.14	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.14	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
7.14	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
7.14	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
7.14	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
7.14	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
7.14	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
7.14	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
7.14	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
7.14	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
7.14	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
7.14	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
7.14	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
7.14	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
7.14	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
7.14	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
7.14	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
7.14	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
7.14	Single	8YRG	Fospropofol	8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
7.14	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
7.14	Single	9B9Y	7DY	9B9Y-CB₁-7DY
7.14	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
7.14	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
7.14	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
7.14	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.14	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
7.14	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
6.90	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
6.90	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.90	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.90	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
6.90	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.90	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
6.67	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
6.67	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
6.67	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
6.67	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
6.67	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
6.67	Single	5U09	Taranabant	5U09-CB₁-Taranabant
6.67	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
6.67	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
6.67	Single	6OBA	S-Alprenolol	6OBA-β₂-S-Alprenolol-GTPL11074
6.67	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
6.67	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
6.67	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
6.67	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
6.67	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
6.67	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.67	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
6.67	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.67	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2
6.67	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
6.67	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
6.67	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
6.67	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
6.67	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
6.67	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
6.67	Single	8IW4	Spermidine	8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8IWE	Spermidine	8IWE-TA9-Spermidine
6.67	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
6.67	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
6.67	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
6.67	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.67	Single	8UNS	Constrained Epinephrine	8UNS-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8UNT	Constrained Epinephrine	8UNT-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
6.67	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.67	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
6.67	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
6.67	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
6.67	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
6.67	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.67	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
6.67	Consensus	gs_5ht	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2 7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2 7XT8-5-HT₄-Serotonin-Gs/β1/γ2
6.67	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
6.67	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
6.67	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
6.67	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.67	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.45	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.45	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.25	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
6.25	Single	3REY	XAC	3REY-A_2A-XAC
6.25	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
6.25	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
6.25	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
6.25	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
6.25	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
6.25	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
6.25	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
6.25	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
6.25	Single	6PS0	S-Carazolol	6PS0-β₂-S-Carazolol
6.25	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
6.25	Single	6PS5	S-Propranolol	6PS5-β₂-S-Propranolol
6.25	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
6.25	Single	6TPK	Retosiban	6TPK-OT-Retosiban
6.25	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
6.25	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
6.25	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
6.25	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
6.25	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
6.25	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
6.25	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
6.25	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
6.25	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
6.25	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
6.25	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
6.25	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
6.25	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
6.25	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GG7	Constrained Epinephrine	8GG7-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8GGL	Constrained Epinephrine	8GGL-β₂-Constrained Epinephrine
6.25	Single	8GGM	Constrained Epinephrine	8GGM-β₂-Constrained Epinephrine
6.25	Single	8GGP	Constrained Epinephrine	8GGP-β₂-Constrained Epinephrine
6.25	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
6.25	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
6.25	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
6.25	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
6.25	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
6.25	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
6.25	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
6.25	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
6.25	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
6.25	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
6.25	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Single	8UNL	Constrained Epinephrine	8UNL-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNO	Constrained Epinephrine	8UNO-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
6.25	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
6.25	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
6.25	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
6.25	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
6.25	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
6.25	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.25	Consensus	5ht_on_gp	Orthosteric Ligand	5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
6.25	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
6.25	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
6.25	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
6.25	Consensus	sensory_off	Orthosteric Ligand	opsins_off
6.25	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
5.88	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
5.88	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
5.88	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.88	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.88	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.88	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
5.88	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
5.88	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
5.88	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
5.88	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.88	Single	4GBR	S-Carazolol	4GBR-β₂-S-Carazolol
5.88	Single	4QKX	35V	4QKX-β₂-35V
5.88	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
5.88	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
5.88	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
5.88	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
5.88	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
5.88	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
5.88	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
5.88	Single	6IIV	Daltroban	6IIV-TP-Daltroban
5.88	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
5.88	Single	6PRZ	S-Alprenolol	6PRZ-β₂-S-Alprenolol
5.88	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.88	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
5.88	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
5.88	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
5.88	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.88	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
5.88	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.88	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
5.88	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.88	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
5.88	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.88	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
5.88	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
5.88	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
5.88	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
5.88	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
5.88	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.88	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
5.88	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
5.88	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
5.88	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.88	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/β1/γ2
5.88	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.88	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.88	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
5.88	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.88	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1
5.88	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
5.88	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
5.88	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
5.88	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
5.88	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
5.88	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
5.88	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
5.88	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
5.88	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
5.88	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
5.88	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.88	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
5.88	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
5.88	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
5.88	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
5.88	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
5.88	Single	8T1W	CVN424	8T1W-GPR6-CVN424
5.88	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
5.88	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
5.88	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.88	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
5.88	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
5.88	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
5.88	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
5.88	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.88	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.88	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
5.88	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
5.88	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.88	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.88	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.88	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.88	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
5.88	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
5.88	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.88	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.88	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
5.88	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
5.88	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
5.88	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.88	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
5.56	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
5.56	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
5.56	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
5.56	Single	2YCW	S-Carazolol	2YCW-β₁-S-Carazolol
5.56	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
5.56	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
5.56	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
5.56	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
5.56	Single	5D6L	S-Carazolol	5D6L-β₂-S-Carazolol
5.56	Single	5JQH	S-Carazolol	5JQH-β₂-S-Carazolol
5.56	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
5.56	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
5.56	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
5.56	Single	5WQC	EMPA	5WQC-OX₂-EMPA
5.56	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-PubChem 129318963
5.56	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
5.56	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
5.56	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
5.56	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
5.56	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
5.56	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
5.56	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
5.56	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
5.56	Single	6PS3	S-Carvedilol	6PS3-β₂-S-Carvedilol
5.56	Single	6PS6	Timolol	6PS6-β₂-Timolol
5.56	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.56	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.56	Single	7BVQ	S-Carazolol	7BVQ-β₁-S-Carazolol
5.56	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
5.56	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
5.56	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.56	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.56	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.56	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.56	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.56	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
5.56	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
5.56	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
5.56	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
5.56	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
5.56	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
5.56	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.56	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
5.56	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.56	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.56	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
5.56	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.56	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
5.56	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.56	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
5.56	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go1/β1/γ2
5.56	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
5.56	Single	8ZMF	A1L10	8ZMF-5-HT_2C-A1L10
5.56	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
5.56	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.56	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
5.56	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
5.56	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
5.56	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
5.56	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.56	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
5.56	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
5.56	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
5.56	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.56	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
5.56	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
5.56	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
5.56	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
5.56	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
5.56	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
5.56	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.56	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.56	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
5.56	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
5.56	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
5.56	Consensus	ep_off	Orthosteric Ligand	ep4_off
5.56	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.56	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
5.56	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
5.56	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
5.56	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
5.26	Single	3P0G	BI167107	3P0G-β₂-BI167107
5.26	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
5.26	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
5.26	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
5.26	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
5.26	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
5.26	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
5.26	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
5.26	Single	5TZR	MK8666	5TZR-FFA1-MK8666
5.26	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
5.26	Single	5XR8	AM841	5XR8-CB₁-AM841
5.26	Single	5XRA	AM11542	5XRA-CB₁-AM11542
5.26	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.26	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
5.26	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
5.26	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
5.26	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
5.26	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
5.26	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
5.26	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
5.26	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
5.26	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
5.26	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
5.26	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.26	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
5.26	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
5.26	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
5.26	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
5.26	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
5.26	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
5.26	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.26	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
5.26	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
5.26	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
5.26	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
5.26	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
5.26	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
5.26	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
5.26	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
5.26	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.26	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
5.26	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
5.26	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
5.26	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.26	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
5.26	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
5.26	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
5.26	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
5.26	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
5.26	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
5.26	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
5.26	Single	9GE2	ML184	9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
5.26	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
5.26	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
5.26	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
5.26	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
5.26	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
5.26	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
5.26	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
5.26	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.26	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
5.26	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
5.26	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.26	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
5.26	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
5.26	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.26	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.26	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
5.26	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
5.26	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
5.26	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.26	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.00	Single	3D4S	Timolol	3D4S-β₂-Timolol
5.00	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
5.00	Single	4LDE	BI167107	4LDE-β₂-BI167107
5.00	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
5.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
5.00	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
5.00	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
5.00	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
5.00	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1-MK8666; PubChem 127053597
5.00	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
5.00	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
5.00	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
5.00	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
5.00	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
5.00	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
5.00	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
5.00	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
5.00	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
5.00	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.00	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
5.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
5.00	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
5.00	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
5.00	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
5.00	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
5.00	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
5.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
5.00	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
5.00	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
5.00	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
5.00	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.00	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
5.00	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
5.00	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-Gi1/β1/γ1
5.00	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
5.00	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
5.00	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
5.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
5.00	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
5.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.00	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
5.00	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.00	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
5.00	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
5.00	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
5.00	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
5.00	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
5.00	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
5.00	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
5.00	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
5.00	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
5.00	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
5.00	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.00	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
5.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
5.00	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.00	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.00	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
5.00	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
5.00	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
5.00	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
5.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
5.00	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.00	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.00	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.00	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
5.00	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
5.00	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.00	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.00	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.76	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.76	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
4.76	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.76	Single	5X93	K-8794	5X93-ET_B-K-8794
4.76	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
4.76	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.76	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.76	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
4.76	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
4.76	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.76	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
4.76	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
4.76	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
4.76	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
4.76	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
4.76	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.76	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
4.76	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.76	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
4.76	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
4.76	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
4.76	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.76	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.76	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
4.76	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
4.76	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
4.76	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
4.76	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.76	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.76	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.76	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.76	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
4.76	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.76	Consensus	endothelin_off	Orthosteric Ligand	etb_off
4.76	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
4.76	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.76	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.76	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
4.76	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
4.76	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.55	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.55	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
4.55	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
4.55	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
4.55	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
4.55	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
4.55	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
4.55	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
4.55	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
4.55	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.55	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
4.55	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
4.55	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.55	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
4.55	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
4.35	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
4.35	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.35	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
4.35	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
4.35	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.35	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.35	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
4.35	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.35	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
4.35	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.35	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
4.35	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
4.35	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.35	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
4.35	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
4.35	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
4.35	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
4.35	Single	8WKY	PG-934	8WKY-MC₄-PG-934
4.35	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.35	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.35	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
4.35	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
4.35	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
4.35	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
4.17	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.17	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
4.17	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
4.17	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
4.17	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.17	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.17	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.17	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
4.17	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
4.17	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.00	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
4.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
4.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
4.00	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
4.00	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
4.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.00	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.85	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.85	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.85	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
3.85	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
3.70	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
3.70	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.45	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.33	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2

PDB Summary
PDB	6PWC
Class	A
SubFamily	Peptide
Type	Neurotensin
SubType	NTS1
Species	Homo Sapiens
Ligand	Neurotensin
Other Ligand(s)	-
Protein Partners	Arrestin2
PDB Resolution	4.9
Date	2019-12-04
D.O.I.	10.1038/s41422-019-0256-2

Net Summary
I_min	2.34
Number of Linked Nodes	642
Number of Links	734
Number of Hubs	92
Number of Links mediated by Hubs	337
Number of Communities	26
Number of Nodes involved in Communities	160
Number of Links involved in Communities	205

Path Summary
Number Of Nodes in MetaPath	108
Number Of Links MetaPath	107
Number of Shortest Paths	615686
Length Of Smallest Path	3
Average Path Length	30.2294
Length of Longest Path	62
Minimum Path Strength	1.205
Average Path Strength	5.75325
Maximum Path Strength	24.14
Minimum Path Correlation	0.7
Average Path Correlation	0.972852
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	42.2577
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.5235
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adult locomotory behavior • behavior • multicellular organismal process • adult behavior • locomotory behavior • system process • learning • learning or memory • nervous system process • cognition • regulation of calcium ion transport • regulation of localization • intracellular calcium ion homeostasis • negative regulation of biological process • negative regulation of transport • calcium ion transport • localization • negative regulation of cation transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • negative regulation of calcium ion transmembrane transport • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • positive regulation of biological process • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • negative regulation of transmembrane transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of sequestering of calcium ion • negative regulation of monoatomic ion transmembrane transport • negative regulation of release of sequestered calcium ion into cytosol • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • negative regulation of cellular process • monoatomic ion transport • intracellular chemical homeostasis • regulation of metal ion transport • regulation of sequestering of calcium ion • positive regulation of cellular process • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • negative regulation of calcium ion transport • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • regulation of postsynaptic membrane potential • regulation of system process • regulation of signal transduction • chemical synaptic transmission, postsynaptic • synaptic signaling • positive regulation of inhibitory postsynaptic potential • positive regulation of nervous system process • regulation of multicellular organismal process • regulation of biological quality • modulation of inhibitory postsynaptic potential • trans-synaptic signaling • regulation of signaling • cell surface receptor signaling pathway • cell-cell signaling • regulation of nervous system process • chemical synaptic transmission • regulation of response to stimulus • anterograde trans-synaptic signaling • inhibitory postsynaptic potential • positive regulation of multicellular organismal process • regulation of cell communication • regulation of membrane potential • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of programmed cell death • positive regulation of apoptotic process • organic acid transmembrane transport • import into cell • nitrogen compound transport • organic anion transport • carboxylic acid transport • carboxylic acid transmembrane transport • aspartate transmembrane transport • import across plasma membrane • amino acid transmembrane transport • C4-dicarboxylate transport • D-amino acid transport • organic acid transport • amino acid transport • D-aspartate transmembrane transport • D-aspartate import across plasma membrane • dicarboxylic acid transport • amino acid import across plasma membrane • positive regulation of arachidonate secretion • regulation of lipid transport • regulation of arachidonate secretion • arachidonate secretion • monocarboxylic acid transport • positive regulation of secretion • fatty acid transport • icosanoid transport • regulation of icosanoid secretion • icosanoid secretion • long-chain fatty acid transport • positive regulation of icosanoid secretion • secretion • arachidonate transport • lipid localization • lipid transport • positive regulation of lipid localization • regulation of fatty acid transport • regulation of secretion • positive regulation of organic acid transport • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • regulation of membrane depolarization • membrane depolarization • polyol metabolic process • alcohol catabolic process • catabolic process • polyol catabolic process • organophosphate catabolic process • alcohol metabolic process • inositol phosphate metabolic process • organophosphate metabolic process • phosphate-containing compound metabolic process • inositol phosphate catabolic process • small molecule metabolic process • small molecule catabolic process • phosphorus metabolic process • detection of external stimulus • detection of stimulus involved in sensory perception of pain • response to external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • L-amino acid transport • L-glutamate import • L-glutamate import across plasma membrane • acidic amino acid transport • L-alpha-amino acid transmembrane transport • L-glutamate transmembrane transport • multicellular organismal-level homeostasis • temperature homeostasis • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • negative regulation of systemic arterial blood pressure • blood circulation • negative regulation of blood pressure • positive regulation of amine transport • gamma-aminobutyric acid transport • regulation of amino acid transport • gamma-aminobutyric acid secretion • regulation of gamma-aminobutyric acid secretion • positive regulation of gamma-aminobutyric acid secretion • acid secretion • amine transport • positive regulation of amino acid transport • regulation of amine transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • response to lipid • response to chemical • regulation of glutamate secretion • positive regulation of secretion by cell • secretion by cell • regulation of secretion by cell • glutamate secretion • positive regulation of glutamate secretion • export from cell • regulation of inositol phosphate biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • regulation of phosphate metabolic process • polyol biosynthetic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • symmetric synapse • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • neuron projection • axon terminus • plasma membrane bounded cell projection • presynapse
Gene Ontology	Cellular Component	• symmetric synapse • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • neuron projection • axon terminus • plasma membrane bounded cell projection • presynapse • cell projection • distal axon • terminal bouton • neuron projection terminus • cell surface • cell periphery • plasma membrane • membrane • membrane microdomain • membrane raft • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • dendrite • dendritic tree • dendritic shaft • neuron spine • dendritic spine • postsynapse • cytoplasmic side of plasma membrane • cytoplasmic side of membrane • side of membrane • endoplasmic reticulum • protein binding • binding • arrestin family protein binding • pyrophosphatase activity • enzyme regulator activity • GTPase activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • hydrolase activity • GTPase regulator activity • enzyme activator activity • ribonucleoside triphosphate phosphatase activity • GTPase activator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • molecular function regulator activity • hydrolase activity, acting on acid anhydrides • catalytic activity • angiotensin receptor binding • signaling receptor binding • G protein-coupled receptor binding • molecular adaptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • insulin-like growth factor receptor binding • molecular function inhibitor activity • enzyme inhibitor activity • transcription coactivator activity • transcription regulator activity • transcription coregulator activity • protein-macromolecule adaptor activity • interleukin-6 production • multicellular organismal process • regulation of cellular process • negative regulation of biological process • regulation of interleukin-6 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of biological process • negative regulation of metabolic process • biological regulation • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of interleukin-6 production • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • negative regulation of post-translational protein modification • regulation of protein modification process • regulation of protein ubiquitination • regulation of primary metabolic process • protein ubiquitination • negative regulation of protein modification process • protein metabolic process • negative regulation of protein ubiquitination • regulation of protein modification by small protein conjugation or removal • protein modification process • negative regulation of protein metabolic process • negative regulation of protein modification by small protein conjugation or removal • regulation of post-translational protein modification • regulation of protein metabolic process • primary metabolic process • macromolecule modification • post-translational protein modification • protein modification by small protein conjugation • protein modification by small protein conjugation or removal • actomyosin structure organization • actin cytoskeleton organization • actin filament organization • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • actin filament bundle organization • contractile actin filament bundle assembly • actin filament-based process • actin filament bundle assembly • stress fiber assembly • cellular component organization or biogenesis • supramolecular fiber organization • cytoskeleton organization • catabolic process • proteolysis involved in protein catabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • proteolysis • ubiquitin-dependent protein catabolic process • muscle hypertrophy • regulation of muscle adaptation • system process • positive regulation of cardiac muscle hypertrophy • response to stimulus • regulation of system process • positive regulation of biological process • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • regulation of response to stimulus • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • positive regulation of multicellular organismal process • negative regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • cellular response to stimulus • negative adaptation of signaling pathway • import into cell • receptor internalization • negative regulation of signaling • signaling • transport • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • vesicle-mediated transport • cell communication • localization • signal transduction • regulation of G protein-coupled receptor signaling pathway • G protein-coupled receptor internalization • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • establishment of localization • adaptation of signaling pathway • regulation of cell communication • G protein-coupled receptor signaling pathway • receptor-mediated endocytosis • endocytosis • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein transport • cellular macromolecule localization • macromolecule localization • regulation of localization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • positive regulation of transport • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • proteasomal protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of DNA-binding transcription factor activity • negative regulation of NF-kappaB transcription factor activity • negative regulation of molecular function • regulation of molecular function • regulation of DNA-binding transcription factor activity • cell surface receptor signaling pathway • Notch signaling pathway • negative regulation of Notch signaling pathway • regulation of Notch signaling pathway • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of phosphorus metabolic process • regulation of phosphorylation • pseudopodium • clathrin-coated pit • cytosol • membraneless organelle • intracellular membraneless organelle • chromatin • chromosome • intracellular vesicle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • endocytic vesicle membrane • vesicle • organelle membrane • endocytic vesicle • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi membrane • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • nuclear body
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30989
Sequence	>6PWC_Chain_R A P S S E L D V N T D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K K S L Q S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V H H P W A F G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A V P M L F T M G E Q N R S A D G Q H A G G L V C T P T I H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I S D E Q W T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F R H I F L A T L A C L C H T L S S N A T R E T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P49407
Sequence	>6PWC_Chain_V R V F K K A S P N G K L T V Y L G K R D F V D H I D L V D P V D G V V L V D P E Y L K E R R V Y V T L T C A F R Y G R E D L D V L G L T F R K D L F C A N V Q S F P P A P E D K K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P C S V T L Q P G P E D T G K A C G V D Y E V K A F C A E N L E E K I H K R N S V R L V I R K V Q Y A P E R P G P Q P T A E T T R Q F L M S D K P L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I C L F N T A Q Y K C P V A M E E A D D T V A P S S T F C K V Y T L T P F L C N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V V S R G G L L G D L A S S D V A V E L P F T L M H P K P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	PubChem 118610427	-	3.02	2023-08-09	10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPC (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg		3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPB (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg		3.07	2023-08-09	10.1038/s41586-023-06395-9
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi1-Go)/β1/γ2	2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8FN1 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	PubChem 118610427	chim(NtGi1-Go)/β1/γ2	2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	PubChem 118610427		2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.59	2023-03-29	10.1021/acs.biochem.3c00029
	8FMZ (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.59	2023-03-29	10.1021/acs.biochem.3c00029
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	10.1038/s41594-022-00859-8
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	10.1126/sciadv.abe5504
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	10.1126/sciadv.abe5504
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.5	2021-01-06	10.1038/s41594-020-00554-6
	7L0S (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.5	2021-01-06	10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0R (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.1	2021-01-06	10.1038/s41594-020-00554-6
	7L0P (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.1	2021-01-06	10.1038/s41594-020-00554-6
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	10.1038/s41586-020-1953-1
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OSA (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	10.1038/s41586-019-1337-6
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OS9 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	10.1038/s41586-019-1337-6
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	10.1038/srep38564
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	10.1038/ncomms8895
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	10.1038/ncomms8895
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	10.1073/pnas.1317903111
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	10.1073/pnas.1317903111
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin-(8-13)	-	-	2.8	2012-10-17	10.1038/nature11558

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