psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D345	R:R:N58	14.81	No	No	0	3	3
2	R:R:D60	R:R:S63	8.83	No	No	2	6	2
3	R:R:D60	R:R:Y349	4.6	No	No	2	6	1
4	R:R:L66	R:R:Y62	4.69	No	No	0	5	3
5	R:R:S63	R:R:Y349	6.36	No	No	2	2	1
6	R:R:K64	R:R:W130	12.76	No	Yes	0	5	7
7	R:R:V67	R:R:Y71	8.83	No	Yes	0	5	7
8	R:R:M352	R:R:V67	4.56	No	No	0	4	5
9	R:R:L125	R:R:T68	7.37	No	No	0	6	6
10	R:R:T68	R:R:W130	7.28	No	Yes	0	6	7
11	R:R:L121	R:R:Y71	4.69	No	Yes	1	7	7
12	R:R:D124	R:R:Y71	8.05	Yes	Yes	1	7	7
13	R:R:L125	R:R:Y71	8.21	No	Yes	1	6	7
14	R:R:I129	R:R:Y71	6.04	No	Yes	1	5	7
15	R:R:N355	R:R:Y71	4.65	Yes	Yes	1	6	7
16	R:R:Y359	R:R:Y71	9.93	Yes	Yes	1	7	7
17	R:R:L74	R:R:V360	5.96	No	No	0	7	6
18	R:R:F75	R:R:T79	5.19	No	No	0	6	6
19	R:R:L114	R:R:T79	4.42	No	No	0	8	6
20	R:R:D113	R:R:N82	4.04	Yes	No	1	9	9
21	R:R:N365	R:R:N82	5.45	Yes	No	1	9	9
22	R:R:N82	R:R:P366	8.15	No	Yes	1	9	9
23	R:R:A110	R:R:T85	3.36	No	No	0	9	9
24	R:R:P366	R:R:T85	3.5	Yes	No	0	9	9
25	R:R:T85	R:R:Y369	9.99	No	Yes	0	9	9
26	R:R:F87	R:R:R91	9.62	No	No	0	3	6
27	R:R:T88	R:R:Y369	3.75	No	Yes	0	7	9
28	R:R:D103	R:R:L89	5.43	No	No	0	8	7
29	R:R:L89	R:R:Y369	8.21	No	Yes	0	7	9
30	R:R:L98	R:R:R101	3.64	No	No	0	8	6
31	R:R:D103	R:R:S100	4.42	No	No	0	8	7
32	R:R:S100	R:R:Y104	3.82	No	Yes	0	7	4
33	R:R:M181	R:R:R101	8.69	Yes	No	0	6	6
34	R:R:R101	R:R:T186	11.64	No	No	0	6	7
35	R:R:R183	R:R:Y104	12.35	No	Yes	3	4	4
36	R:R:T186	R:R:Y104	3.75	No	Yes	0	7	4
37	R:R:K187	R:R:Y104	16.72	No	Yes	3	4	4
38	R:R:S162	R:R:Y105	6.36	No	Yes	0	7	8
39	R:R:L163	R:R:Y105	4.69	No	Yes	0	9	8
40	R:R:E166	R:R:Y105	5.61	No	Yes	0	9	8
41	R:R:T186	R:R:Y105	7.49	No	Yes	0	7	8
42	R:R:I190	R:R:Y105	6.04	No	Yes	0	7	8
43	R:R:N159	R:R:S108	8.94	No	No	0	8	9
44	R:R:I190	R:R:S108	7.74	No	No	0	7	9
45	R:R:L109	R:R:N159	9.61	No	No	0	9	8
46	R:R:L109	R:R:N365	5.49	No	Yes	0	9	9
47	R:R:L111	R:R:L115	4.15	No	No	0	6	6
48	R:R:L111	R:R:W194	6.83	No	No	0	6	9
49	R:R:D113	R:R:S112	4.42	Yes	No	1	9	8
50	R:R:S112	R:R:T156	6.4	No	No	1	8	9
51	R:R:D113	R:R:T156	5.78	Yes	No	1	9	9
52	R:R:A362	R:R:D113	4.63	No	Yes	0	9	9
53	R:R:D113	R:R:N365	9.42	Yes	Yes	1	9	9
54	R:R:L114	R:R:L118	6.92	No	No	0	8	5
55	R:R:C152	R:R:L115	4.76	No	No	0	7	6
56	R:R:C152	R:R:I116	6.55	No	No	0	7	7
57	R:R:L117	R:R:Y359	3.52	No	Yes	0	6	7
58	R:R:A362	R:R:L117	4.73	No	No	0	9	6
59	R:R:F119	R:R:L118	4.87	No	No	0	5	5
60	R:R:L121	R:R:P122	6.57	No	No	0	7	9
61	R:R:L121	R:R:Y359	17.58	No	Yes	1	7	7
62	R:R:F137	R:R:V123	11.8	Yes	No	0	7	5
63	R:R:V123	R:R:Y145	8.83	No	Yes	0	5	6
64	R:R:D124	R:R:F128	4.78	Yes	Yes	1	7	6
65	R:R:D124	R:R:Y145	3.45	Yes	Yes	1	7	6
66	R:R:D124	R:R:Y351	6.9	Yes	Yes	1	7	4
67	R:R:D124	R:R:N355	6.73	Yes	Yes	1	7	6
68	R:R:D124	R:R:Y359	10.34	Yes	Yes	1	7	7
69	R:R:I129	R:R:L125	4.28	No	No	1	5	6
70	R:R:N127	R:R:Y126	8.14	Yes	No	0	5	4
71	R:R:V131	R:R:Y126	15.14	No	No	0	5	4
72	R:R:N127	R:R:W135	16.95	Yes	Yes	1	5	9
73	R:R:F137	R:R:N127	9.67	Yes	Yes	1	7	5
74	R:R:F128	R:R:W135	5.01	Yes	Yes	1	6	9
75	R:R:F128	R:R:Y145	8.25	Yes	Yes	1	6	6
76	R:R:F128	R:R:Y146	6.19	Yes	Yes	1	6	5
77	R:R:F128	R:R:Y351	9.28	Yes	Yes	1	6	4
78	R:R:P134	R:R:V131	5.3	No	No	0	5	5
79	R:R:F137	R:R:W135	7.02	Yes	Yes	1	7	9
80	R:R:C142	R:R:W135	3.92	No	Yes	1	9	9
81	R:R:L210	R:R:W135	9.11	Yes	Yes	1	5	9
82	R:R:C225	R:R:W135	10.45	No	Yes	1	9	9
83	R:R:D139	R:R:K143	9.68	No	No	0	3	7
84	R:R:C142	R:R:L210	6.35	No	Yes	1	9	5
85	R:R:C142	R:R:C225	7.28	No	No	1	9	9
86	R:R:G209	R:R:K143	5.23	No	No	0	3	7
87	R:R:Y145	R:R:Y146	12.91	Yes	Yes	1	6	5
88	R:R:R149	R:R:Y146	7.2	Yes	Yes	1	7	5
89	R:R:M204	R:R:Y146	4.79	No	Yes	0	6	5
90	R:R:M208	R:R:Y146	14.37	No	Yes	0	5	5
91	R:R:F147	R:R:L148	3.65	Yes	No	0	5	5
92	R:R:F147	R:R:L205	10.96	Yes	No	0	5	5
93	R:R:E150	R:R:R149	18.61	Yes	Yes	1	6	7
94	R:R:R149	R:R:T153	3.88	Yes	Yes	1	7	7
95	R:R:R149	R:R:Y324	11.32	Yes	Yes	1	7	5
96	R:R:R149	R:R:R328	6.4	Yes	Yes	1	7	6
97	R:R:E150	R:R:T153	9.88	Yes	Yes	1	6	7
98	R:R:E150	R:R:M204	5.41	Yes	No	0	6	6
99	R:R:E150	R:R:N241	9.2	Yes	No	1	6	5
100	R:R:E150	R:R:Y324	3.37	Yes	Yes	1	6	5
101	R:R:E150	R:R:R328	9.3	Yes	Yes	1	6	6
102	R:R:T153	R:R:W321	4.85	Yes	Yes	1	7	8
103	R:R:T153	R:R:Y324	3.75	Yes	Yes	1	7	5
104	R:R:L200	R:R:Y154	12.89	No	Yes	0	5	6
105	R:R:N241	R:R:Y154	6.98	No	Yes	0	5	6
106	R:R:M244	R:R:Y154	4.79	No	Yes	0	4	6
107	R:R:S245	R:R:Y154	7.63	No	Yes	0	6	6
108	R:R:A155	R:R:W194	6.48	No	No	0	7	9
109	R:R:A155	R:R:S197	3.42	No	No	0	7	8
110	R:R:F317	R:R:T156	3.89	Yes	No	1	9	9
111	R:R:A157	R:R:P249	3.74	No	No	0	7	9
112	R:R:A157	R:R:F317	4.16	No	Yes	0	7	9
113	R:R:I193	R:R:L158	4.28	No	No	0	8	7
114	R:R:V160	R:R:V313	4.81	No	No	0	8	8
115	R:R:F317	R:R:V160	3.93	Yes	No	0	9	8
116	R:R:S164	R:R:V161	3.23	No	No	0	9	7
117	R:R:P249	R:R:V161	3.53	No	No	0	9	7
118	R:R:I193	R:R:S162	4.64	No	No	0	8	7
119	R:R:N257	R:R:S164	5.96	No	No	0	9	9
120	R:R:E166	R:R:L169	3.98	No	No	4	9	4
121	R:R:E166	R:R:M181	9.47	No	Yes	4	9	6
122	R:R:I171	R:R:L167	4.28	Yes	No	0	8	9
123	R:R:L167	R:R:L310	6.92	No	No	0	9	8
124	R:R:C172	R:R:Y168	14.79	No	Yes	5	7	8
125	R:R:H173	R:R:Y168	4.36	No	Yes	5	6	8
126	R:R:L256	R:R:Y168	8.21	No	Yes	0	7	8
127	R:R:V259	R:R:Y168	3.79	No	Yes	0	5	8
128	R:R:L169	R:R:M181	4.24	No	Yes	4	4	6
129	R:R:I171	R:R:L264	4.28	Yes	No	0	8	8
130	R:R:I171	R:R:L303	5.71	Yes	No	0	8	8
131	R:R:C172	R:R:H173	11.79	No	No	5	7	6
132	R:R:H173	R:R:K176	11.79	No	No	0	6	5
133	R:R:K178	R:R:R299	4.95	No	No	0	4	5
134	R:R:L180	R:R:M181	9.9	No	Yes	0	5	6
135	R:R:L180	R:R:R185	6.07	No	No	0	5	6
136	R:R:S182	R:R:S184	3.26	No	No	0	7	4
137	R:R:R185	R:R:S182	6.59	No	No	0	6	7
138	R:R:K187	R:R:R183	22.28	No	No	3	4	4
139	R:R:F189	R:R:R185	6.41	No	No	0	5	6
140	R:R:L195	R:R:L199	4.15	No	No	0	3	4
141	R:R:I202	R:R:P203	3.39	No	No	0	4	8
142	R:R:F206	R:R:I202	3.77	No	No	0	4	4
143	R:R:M204	R:R:T207	4.52	No	No	0	6	4
144	R:R:T207	R:R:V229	6.35	No	No	0	4	5
145	R:R:M208	R:R:P227	8.39	No	No	0	5	5
146	R:R:G209	R:R:I228	3.53	No	No	0	3	3
147	R:R:L210	R:R:L223	6.92	Yes	No	0	5	3
148	R:R:Q211	R:R:T226	8.5	No	No	0	3	3
149	R:R:L213	R:R:V224	5.96	No	No	0	2	5
150	R:R:P227	R:R:T226	5.25	No	No	0	5	3
151	R:R:L234	R:R:P227	6.57	No	No	0	5	5
152	R:R:T233	R:R:V229	7.93	No	No	0	4	5
153	R:R:D230	R:R:T233	10.12	No	No	0	4	4
154	R:R:I238	R:R:L234	4.28	No	No	0	5	5
155	R:R:R235	R:R:Y333	13.38	No	No	0	4	5
156	R:R:I238	R:R:R328	5.01	No	Yes	0	5	6
157	R:R:I238	R:R:V332	4.61	No	No	0	5	4
158	R:R:L329	R:R:Q239	3.99	No	No	0	5	6
159	R:R:Q239	R:R:Y333	6.76	No	No	0	6	5
160	R:R:L240	R:R:M244	5.65	No	No	0	4	4
161	R:R:N241	R:R:R328	3.62	No	Yes	1	5	6
162	R:R:H325	R:R:T242	6.85	Yes	No	0	7	5
163	R:R:L329	R:R:T242	10.32	No	No	0	5	5
164	R:R:F243	R:R:F248	4.29	No	No	0	4	5
165	R:R:F246	R:R:M250	4.98	Yes	No	1	8	7
166	R:R:F246	R:R:F317	4.29	Yes	Yes	1	8	9
167	R:R:F246	R:R:L322	3.65	Yes	No	0	8	6
168	R:R:F246	R:R:H325	13.58	Yes	Yes	1	8	7
169	R:R:F248	R:R:P249	7.22	No	No	0	5	9
170	R:R:F317	R:R:M250	9.95	Yes	No	1	9	7
171	R:R:S254	R:R:V314	3.23	No	No	0	5	8
172	R:R:L310	R:R:N257	5.49	No	No	0	8	9
173	R:R:N257	R:R:V314	4.43	No	No	0	9	8
174	R:R:R262	R:R:V266	5.23	No	No	0	5	5
175	R:R:M267	R:R:R263	7.44	No	No	0	6	5
176	R:R:M293	R:R:N292	7.01	No	No	0	3	3
177	R:R:M293	R:R:P297	3.35	No	No	0	3	3
178	R:R:P297	R:R:V300	7.07	No	No	0	3	3
179	R:R:G298	R:R:Q301	3.29	No	No	0	3	5
180	R:R:L303	R:R:R299	7.29	No	No	0	8	5
181	R:R:L308	R:R:R304	12.15	No	No	0	7	6
182	R:R:L308	R:R:R311	3.64	No	No	0	7	5
183	R:R:L368	R:R:V313	5.96	No	No	0	8	8
184	R:R:F317	R:R:W321	20.04	Yes	Yes	1	9	8
185	R:R:C320	R:R:S361	6.89	No	No	0	8	9
186	R:R:W321	R:R:Y324	6.75	Yes	Yes	1	8	5
187	R:R:V358	R:R:W321	11.03	No	Yes	1	7	8
188	R:R:S361	R:R:W321	6.18	No	Yes	0	9	8
189	R:R:L322	R:R:P323	4.93	No	No	0	6	9
190	R:R:L357	R:R:P323	3.28	No	No	0	7	9
191	R:R:H325	R:R:Y324	8.71	Yes	Yes	1	7	5
192	R:R:R327	R:R:Y324	4.12	Yes	Yes	1	5	5
193	R:R:R328	R:R:Y324	13.38	Yes	Yes	1	6	5
194	R:R:V358	R:R:Y324	5.05	No	Yes	1	7	5
195	R:R:H325	R:R:R328	5.64	Yes	Yes	1	7	6
196	R:R:M330	R:R:V326	4.56	No	No	0	5	5
197	R:R:R327	R:R:Y347	9.26	Yes	No	1	5	4
198	R:R:F350	R:R:R327	5.34	No	Yes	0	5	5
199	R:R:R327	R:R:Y351	15.43	Yes	Yes	1	5	4
200	R:R:R327	R:R:S354	10.54	Yes	No	0	5	5
201	R:R:N355	R:R:R327	7.23	Yes	Yes	1	6	5
202	R:R:I334	R:R:M330	4.37	No	No	0	3	5
203	R:R:F331	R:R:Y347	8.25	No	No	0	3	4
204	R:R:V332	R:R:Y333	3.79	No	No	0	4	5
205	R:R:D336	R:R:Q338	15.66	No	No	0	2	1
206	R:R:L343	R:R:W339	4.56	No	No	0	2	7
207	R:R:F346	R:R:F350	8.57	No	No	0	4	5
208	R:R:Y347	R:R:Y351	3.97	No	Yes	1	4	4
209	R:R:H348	R:R:M352	9.19	No	No	0	4	4
210	R:R:N355	R:R:Y351	15.12	Yes	Yes	1	6	4
211	R:R:N365	R:R:P366	6.52	Yes	Yes	1	9	9
212	R:R:N370	R:R:Y369	3.49	No	Yes	0	7	9
213	R:R:A271	R:R:M293	3.22	No	No	0	6	3
214	R:R:V161	R:R:V252	3.21	No	No	0	7	5
215	R:R:T207	R:R:V237	3.17	No	No	0	4	7
216	R:R:T226	R:R:V224	3.17	No	No	0	3	5
217	R:R:A363	R:R:L74	3.15	No	No	0	6	7
218	R:R:A110	R:R:L86	3.15	No	No	0	9	7
219	R:R:E296	R:R:P297	3.14	No	No	0	5	3
220	R:R:T340	R:R:T341	3.14	No	No	0	7	4
221	R:R:M352	R:R:S63	3.07	No	No	0	4	2
222	R:R:I364	R:R:V360	3.07	No	No	0	6	6
223	R:R:H133	R:R:P134	3.05	No	No	0	5	5
224	R:R:M250	R:R:V318	3.04	No	No	0	7	6
225	R:R:L106	R:R:V102	2.98	No	No	0	8	8
226	R:R:L256	R:R:V165	2.98	No	No	0	7	6
227	R:R:L256	R:R:V252	2.98	No	No	0	7	5
228	R:R:L264	R:R:V268	2.98	No	No	0	8	5
229	R:R:L371	R:R:V309	2.98	No	No	0	5	8
230	R:R:L247	R:R:T242	2.95	No	No	0	5	5
231	R:R:I364	R:R:I367	2.94	No	No	0	6	7
232	R:R:D103	R:R:V102	2.92	No	No	0	8	8
233	R:R:F75	R:R:P122	2.89	No	No	0	6	9
234	R:R:Q99	R:R:V102	2.87	No	No	0	7	8
235	R:R:I70	R:R:L74	2.85	No	No	0	4	7
236	R:R:I367	R:R:L371	2.85	No	No	0	7	5
237	R:R:G138	R:R:W135	2.81	No	Yes	0	8	9
238	R:R:A201	R:R:F147	2.77	No	Yes	0	7	5
239	R:R:H269	R:R:T265	2.74	No	No	0	4	5
240	R:R:D139	R:R:L210	2.71	No	Yes	0	3	5
241	R:R:A120	R:R:Y359	2.67	No	Yes	0	6	7
242	R:R:R263	R:R:V266	2.62	No	No	0	5	5
243	R:R:R304	R:R:V307	2.62	No	No	0	6	7
244	R:R:F350	R:R:V326	2.62	No	No	0	5	5
245	R:R:S197	R:R:Y154	2.54	No	Yes	0	8	6
246	R:R:I171	R:R:R263	2.51	Yes	No	0	8	5
247	R:R:I315	R:R:R311	2.51	No	No	0	5	5
248	R:R:V65	R:R:W130	2.45	No	Yes	0	5	7
249	R:R:L264	R:R:R304	2.43	No	No	0	8	6
250	R:R:D345	R:R:F344	2.39	No	No	0	3	3
251	R:R:I61	R:R:W130	2.35	No	Yes	0	3	7
252	R:R:G221	R:R:G222	2.11	No	Yes	0	4	2
253	R:R:G81	R:R:P366	2.03	No	Yes	0	8	9
254	R:R:A363	R:R:G78	1.95	No	No	0	6	8
255	R:R:A110	R:R:G107	1.95	No	No	0	9	5
256	R:R:A140	R:R:G141	1.95	No	No	0	1	4
257	R:R:G222	R:R:S214	1.86	Yes	No	0	2	4
258	R:R:G78	R:R:V77	1.84	No	No	0	8	5
259	R:R:G81	R:R:V80	1.84	No	No	0	8	4
260	R:R:A151	R:R:A201	1.79	No	No	0	5	7
261	R:R:P203	R:R:V237	1.77	No	No	0	8	7
262	R:R:G144	R:R:K143	1.74	No	No	0	4	7
263	R:R:G78	R:R:L117	1.71	No	No	0	8	6
264	R:R:G83	R:R:L86	1.71	No	No	0	4	7
265	R:R:G83	R:R:L114	1.71	No	No	0	4	8
266	R:R:A253	R:R:S164	1.71	No	No	0	8	9
267	R:R:G306	R:R:L167	1.71	No	No	0	8	9
268	R:R:G222	R:R:L223	1.71	Yes	No	0	2	3
269	R:R:C320	R:R:V360	1.71	No	No	0	8	6
270	R:R:G222	R:R:N212	1.7	Yes	No	0	2	2
271	R:R:A261	R:R:V307	1.7	No	No	0	6	7
272	R:R:A342	R:R:T340	1.68	No	No	0	3	7
273	R:R:K178	R:R:P174	1.67	No	No	0	4	9
274	R:R:A260	R:R:I171	1.62	No	Yes	0	8	8
275	R:R:A177	R:R:M181	1.61	No	Yes	0	6	6
276	R:R:V76	R:R:V77	1.6	No	No	0	5	5
277	R:R:V80	R:R:V84	1.6	No	No	0	4	6
278	R:R:S335	R:R:T231	1.6	No	No	0	3	1
279	R:R:V268	R:R:V300	1.6	No	No	0	5	3
280	R:R:A170	R:R:L303	1.58	No	No	0	8	8
281	R:R:A136	R:R:N127	1.56	No	Yes	0	4	5
282	R:R:A232	R:R:D230	1.54	No	No	0	3	4
283	R:R:I255	R:R:V259	1.54	No	No	0	4	5
284	R:R:I315	R:R:V319	1.54	No	No	0	5	5
285	R:R:F137	R:R:G141	1.51	Yes	No	0	7	4
286	R:R:F147	R:R:G144	1.51	Yes	No	0	5	4
287	R:R:A201	R:R:E150	1.51	No	Yes	0	7	6
288	R:R:K64	R:R:T59	1.5	No	No	0	5	2
289	R:R:G306	R:R:R305	1.5	No	No	0	8	8
290	R:R:L72	R:R:T68	1.47	No	No	0	3	6
291	R:R:L180	R:R:T179	1.47	No	No	0	5	4
292	R:R:L343	R:R:T340	1.47	No	No	0	2	7
293	R:R:I70	R:R:L66	1.43	No	No	0	4	5
294	R:R:I202	R:R:L199	1.43	No	No	0	4	4
295	R:R:I334	R:R:L343	1.43	No	No	0	3	2
296	R:R:I334	R:R:Q338	1.37	No	No	0	3	1
297	R:R:A356	R:R:Y71	1.33	No	Yes	0	5	7
298	R:R:F291	R:R:N292	1.21	No	No	0	1	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y71	6.46625	8	1	7
2	R:R:Y104	9.16	4	3	4
3	R:R:Y105	6.038	5	0	8
4	R:R:D113	5.658	5	1	9
5	R:R:D124	6.70833	6	1	7
6	R:R:N127	9.08	4	1	5
7	R:R:F128	6.702	5	1	6
8	R:R:W130	6.21	4	0	7
9	R:R:W135	7.89571	7	1	9
10	R:R:F137	7.5	4	1	7
11	R:R:Y145	8.36	4	1	6
12	R:R:Y146	9.092	5	1	5
13	R:R:F147	4.7225	4	0	5
14	R:R:R149	9.482	5	1	7
15	R:R:E150	8.18286	7	1	6
16	R:R:T153	5.59	4	1	7
17	R:R:Y154	6.966	5	0	6
18	R:R:Y168	7.7875	4	5	8
19	R:R:I171	3.68	5	0	8
20	R:R:M181	6.782	5	4	6
21	R:R:L210	6.2725	4	1	5
22	R:R:G222	1.845	4	0	2
23	R:R:F246	6.625	4	1	8
24	R:R:F317	7.71	6	1	9
25	R:R:W321	9.77	5	1	8
26	R:R:Y324	7.05625	8	1	5
27	R:R:H325	8.695	4	1	7
28	R:R:R327	8.65333	6	1	5
29	R:R:R328	7.225	6	1	6
30	R:R:Y351	10.14	5	1	4
31	R:R:N355	8.4325	4	1	6
32	R:R:Y359	8.808	5	1	7
33	R:R:N365	6.72	4	1	9
34	R:R:P366	5.05	4	1	9
35	R:R:Y369	6.36	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L117	R:R:Y359	32.4501	3.52	No	Yes	0	6	7
2	R:R:G78	R:R:L117	13.4346	1.71	No	No	0	8	6
3	R:R:L125	R:R:Y71	10.746	8.21	No	Yes	1	6	7
4	R:R:N355	R:R:Y71	15.4219	4.65	Yes	Yes	1	6	7
5	R:R:L121	R:R:P122	10.6291	6.57	No	No	0	7	9
6	R:R:A362	R:R:D113	28.4366	4.63	No	Yes	0	9	9
7	R:R:A362	R:R:L117	28.1595	4.73	No	No	0	9	6
8	R:R:D113	R:R:N82	29.2938	4.04	Yes	No	1	9	9
9	R:R:D113	R:R:N365	63.4714	9.42	Yes	Yes	1	9	9
10	R:R:N82	R:R:P366	28.0296	8.15	No	Yes	1	9	9
11	R:R:N365	R:R:P366	28.9432	6.52	Yes	Yes	1	9	9
12	R:R:A110	R:R:T85	11.3175	3.36	No	No	0	9	9
13	R:R:P366	R:R:T85	46.0493	3.5	Yes	No	0	9	9
14	R:R:T85	R:R:Y369	34.5543	9.99	No	Yes	0	9	9
15	R:R:D103	R:R:L89	23.765	5.43	No	No	0	8	7
16	R:R:L89	R:R:Y369	26.4666	8.21	No	Yes	0	7	9
17	R:R:L109	R:R:N365	35.2903	5.49	No	Yes	0	9	9
18	R:R:L109	R:R:N159	33.9222	9.61	No	No	0	9	8
19	R:R:N159	R:R:S108	32.567	8.94	No	No	0	8	9
20	R:R:I190	R:R:S108	31.2248	7.74	No	No	0	7	9
21	R:R:I190	R:R:Y105	29.8913	6.04	No	Yes	0	7	8
22	R:R:D103	R:R:S100	12.9108	4.42	No	No	0	8	7
23	R:R:S100	R:R:Y104	10.1831	3.82	No	Yes	0	7	4
24	R:R:E166	R:R:Y105	14.5344	5.61	No	Yes	0	9	8
25	R:R:E166	R:R:M181	11.5383	9.47	No	Yes	4	9	6
26	R:R:N355	R:R:R327	17.5824	7.23	Yes	Yes	1	6	5
27	R:R:R327	R:R:Y324	38.6674	4.12	Yes	Yes	1	5	5
28	R:R:E150	R:R:Y324	29.0297	3.37	Yes	Yes	1	6	5
29	R:R:E150	R:R:N241	25.2111	9.2	Yes	No	1	6	5
30	R:R:N241	R:R:Y154	43.7416	6.98	No	Yes	0	5	6
31	R:R:S197	R:R:Y154	25.6657	2.54	No	Yes	0	8	6
32	R:R:A155	R:R:S197	22.0245	3.42	No	No	0	7	8
33	R:R:A155	R:R:W194	18.3747	6.48	No	No	0	7	9
34	R:R:L111	R:R:W194	14.7162	6.83	No	No	0	6	9
35	R:R:R328	R:R:Y324	19.8511	13.38	Yes	Yes	1	6	5
36	R:R:N241	R:R:R328	22.1154	3.62	No	Yes	1	5	6
37	R:R:L111	R:R:L115	11.0491	4.15	No	No	0	6	6
38	R:R:D113	R:R:T156	73.0268	5.78	Yes	No	1	9	9
39	R:R:D124	R:R:F128	20.5957	4.78	Yes	Yes	1	7	6
40	R:R:F128	R:R:W135	40.3083	5.01	Yes	Yes	1	6	9
41	R:R:D124	R:R:Y145	10.6897	3.45	Yes	Yes	1	7	6
42	R:R:N127	R:R:W135	12.0752	16.95	Yes	Yes	1	5	9
43	R:R:F128	R:R:Y146	28.9258	6.19	Yes	Yes	1	6	5
44	R:R:Y145	R:R:Y146	12.7852	12.91	Yes	Yes	1	6	5
45	R:R:L210	R:R:W135	16.0584	9.11	Yes	Yes	1	5	9
46	R:R:R149	R:R:Y146	33.2424	7.2	Yes	Yes	1	7	5
47	R:R:R149	R:R:Y324	14.136	11.32	Yes	Yes	1	7	5
48	R:R:M208	R:R:Y146	15.9458	14.37	No	Yes	0	5	5
49	R:R:A201	R:R:E150	17.1061	1.51	No	Yes	0	7	6
50	R:R:A201	R:R:F147	13.019	2.77	No	Yes	0	7	5
51	R:R:W321	R:R:Y324	69.9312	6.75	Yes	Yes	1	8	5
52	R:R:F317	R:R:W321	100	20.04	Yes	Yes	1	9	8
53	R:R:A157	R:R:F317	80.4433	4.16	No	Yes	0	7	9
54	R:R:A157	R:R:P249	79.0406	3.74	No	No	0	7	9
55	R:R:P249	R:R:V161	74.7803	3.53	No	No	0	9	7
56	R:R:S164	R:R:V161	60.0165	3.23	No	No	0	9	7
57	R:R:N257	R:R:S164	56.9598	5.96	No	No	0	9	9
58	R:R:L310	R:R:N257	52.3098	5.49	No	No	0	8	9
59	R:R:L167	R:R:L310	50.7209	6.92	No	No	0	9	8
60	R:R:I171	R:R:L167	45.967	4.28	Yes	No	0	8	9
61	R:R:L256	R:R:Y168	10.8282	8.21	No	Yes	0	7	8
62	R:R:L256	R:R:V252	14.3698	2.98	No	No	0	7	5
63	R:R:V161	R:R:V252	16.1276	3.21	No	No	0	7	5
64	R:R:I171	R:R:L264	27.969	4.28	Yes	No	0	8	8
65	R:R:M204	R:R:T207	22.8082	4.52	No	No	0	6	4
66	R:R:T207	R:R:V237	12.5687	3.17	No	No	0	4	7
67	R:R:P203	R:R:V237	10.4949	1.77	No	No	0	8	7
68	R:R:M208	R:R:P227	13.3004	8.39	No	No	0	5	5
69	R:R:L210	R:R:L223	10.1485	6.92	Yes	No	0	5	3
70	R:R:P227	R:R:T226	15.6167	5.25	No	No	0	5	3
71	R:R:I238	R:R:R328	15.5778	5.01	No	Yes	0	5	6
72	R:R:F246	R:R:H325	22.1544	13.58	Yes	Yes	1	8	7
73	R:R:L264	R:R:V268	14.1404	2.98	No	No	0	8	5
74	R:R:V268	R:R:V300	12.4778	1.6	No	No	0	5	3
75	R:R:P297	R:R:V300	10.8153	7.07	No	No	0	3	3
76	R:R:L264	R:R:R304	12.6034	2.43	No	No	0	8	6
77	R:R:C320	R:R:S361	12.9844	6.89	No	No	0	8	9
78	R:R:S361	R:R:W321	14.556	6.18	No	Yes	0	9	8
79	R:R:F350	R:R:R327	16.0367	5.34	No	Yes	0	5	5
80	R:R:F350	R:R:V326	13.4866	2.62	No	No	0	5	5
81	R:R:M330	R:R:V326	12.1704	4.56	No	No	0	5	5
82	R:R:I334	R:R:M330	10.8412	4.37	No	No	0	3	5
83	R:R:D124	R:R:Y359	27.2373	10.34	Yes	Yes	1	7	7
84	R:R:E150	R:R:T153	21.3837	9.88	Yes	Yes	1	6	7
85	R:R:T153	R:R:W321	33.7966	4.85	Yes	Yes	1	7	8
86	R:R:C320	R:R:V360	11.4777	1.71	No	No	0	8	6
87	R:R:F317	R:R:T156	74.7716	3.89	Yes	No	1	9	9
88	R:R:R149	R:R:T153	12.1574	3.88	Yes	Yes	1	7	7
89	R:R:E150	R:R:M204	21.2668	5.41	Yes	No	0	6	6
90	R:R:F246	R:R:F317	19.5047	4.29	Yes	Yes	1	8	9
91	R:R:R327	R:R:Y351	11.889	15.43	Yes	Yes	1	5	4
92	R:R:H325	R:R:R328	16.4437	5.64	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6Z66

PDB Summary
PDB	6Z66
Class	A
SubFamily	Peptide
Type	Neurotensin
SubType	NTS1
Species	Rattus norvegicus
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.19
Date	2021-02-10
D.O.I.	10.1126/sciadv.abe5504

Net Summary
I_min	3.23
Number of Linked Nodes	262
Number of Links	298
Number of Hubs	35
Number of Links mediated by Hubs	133
Number of Communities	5
Number of Nodes involved in Communities	49
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	59997
Length Of Smallest Path	3
Average Path Length	13.3922
Length of Longest Path	30
Minimum Path Strength	1.4
Average Path Strength	6.22205
Maximum Path Strength	15.535
Minimum Path Correlation	0.7
Average Path Correlation	0.935974
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	58.9704
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.9256
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P20789
Sequence	>6Z66_Chain_R N T D I Y S K V L V T A I Y L A L F V V G T V G N G V T L F T L A R K S L Q S R V D Y Y L G S L A L S D L L I L L F A L P V D L Y N F I W V H H P W A F G D A G C K G Y Y F L R E A C T Y A T A L N V V S L S V E L Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A I P M L F T M G L Q N L S G G L V C T P I V D T A T L R V V I Q L N T F M S F L F P M L V A S I L N T V A A R R L T V M V H Q A A F N M T I E P G R V Q A L R R G V L V L R A V V I A F V V C W L P Y H V R R L M F V Y I S D E Q W T T A L F D F Y H Y F Y M L S N A L V Y V S A A I N P I L Y N L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	10.1073/pnas.1317903111
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	10.1073/pnas.1317903111
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin 8-13	-	-	2.8	2012-10-17	10.1038/nature11558
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	10.1038/ncomms8895
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	10.1038/ncomms8895
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	10.1038/srep38564
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/&β;1/&γ;2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/&β;1/&γ;2	3	2019-07-10	10.1038/s41586-019-1337-6
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	10.1038/s41422-019-0256-2
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	10.1038/s41586-020-1953-1
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	10.1126/sciadv.abe5504
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	10.1126/sciadv.abe5504
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/&β;1/&γ;1	4.1	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/&β;1/&γ;1	4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/&β;1/&γ;1	4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/&β;1/γ1	4.5	2021-01-06	10.1038/s41594-020-00554-6
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	10.1038/s41594-022-00859-8
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/neuromedin N	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	2.59	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/neuromedin N	PubChem 118610427	chim(NtGi1-Go)/&β;1/&γ;2	2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/neuromedin N	-	chim(NtGi1-Go)/&β;1/&γ;2	2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin 8-13	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin 8-13	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	PubChem 118610427	-	3.02	2023-08-09	10.1038/s41586-023-06395-9
	6YVR (Dimer)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	10.1126/sciadv.abe5504

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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