psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R8	R:R:D54	7.15	No	No	0	0	4
2	L:L:R8	R:R:F344	7.48	No	Yes	0	0	3
3	L:L:R9	R:R:W339	6	No	Yes	0	0	7
4	L:L:P10	R:R:W339	12.16	No	Yes	1	0	7
5	L:L:P10	R:R:F344	10.11	No	Yes	0	0	3
6	L:L:P10	R:R:Y347	11.13	No	Yes	1	0	4
7	L:L:I12	L:L:Y11	10.88	No	No	0	0	0
8	L:L:Y11	R:R:V224	12.62	No	No	0	0	5
9	L:L:I12	R:R:F128	15.07	No	Yes	1	0	6
10	L:L:I12	R:R:Y351	3.63	No	Yes	1	0	4
11	L:L:L13	R:R:M208	5.65	Yes	No	1	0	5
12	L:L:L13	R:R:P227	3.28	Yes	Yes	1	0	5
13	L:L:L13	R:R:R327	3.64	Yes	Yes	1	0	5
14	L:L:L13	R:R:R328	4.86	Yes	Yes	0	0	6
15	L:L:L13	R:R:F331	10.96	Yes	No	1	0	3
16	R:R:H219	R:R:N52	24.23	Yes	No	0	3	3
17	R:R:H133	R:R:L55	15.43	No	No	0	5	2
18	R:R:L55	R:R:R213	3.64	No	No	0	2	2
19	R:R:H132	R:R:V57	5.54	No	No	3	5	2
20	R:R:F344	R:R:V57	10.49	Yes	No	0	3	2
21	R:R:H348	R:R:V57	9.69	Yes	No	3	4	2
22	R:R:K64	R:R:T59	7.51	No	No	0	5	2
23	R:R:H348	R:R:T59	5.48	Yes	No	0	4	2
24	R:R:D60	R:R:I61	4.2	No	No	0	6	3
25	R:R:D60	R:R:Y62	3.45	No	No	0	6	3
26	R:R:D60	R:R:S63	5.89	No	No	0	6	2
27	R:R:S63	R:R:Y349	7.63	No	No	0	2	1
28	R:R:K64	R:R:W130	6.96	No	No	0	5	7
29	R:R:M352	R:R:V67	4.56	No	No	0	4	5
30	R:R:T68	R:R:W130	14.55	No	No	0	6	7
31	R:R:I70	R:R:L74	4.28	No	No	0	4	7
32	R:R:M121	R:R:Y71	3.59	Yes	Yes	0	7	7
33	R:R:L125	R:R:Y71	10.55	No	Yes	1	6	7
34	R:R:I129	R:R:Y71	4.84	No	Yes	1	5	7
35	R:R:N355	R:R:Y71	5.81	Yes	Yes	1	6	7
36	R:R:A356	R:R:Y71	5.34	No	Yes	0	5	7
37	R:R:F75	R:R:T79	7.78	No	No	0	6	6
38	R:R:F75	R:R:M121	8.71	No	Yes	0	6	7
39	R:R:G81	R:R:P366	4.06	No	No	0	8	9
40	R:R:D113	R:R:N82	6.73	No	Yes	0	9	9
41	R:R:L117	R:R:N82	4.12	No	Yes	0	6	9
42	R:R:N82	R:R:P366	9.77	Yes	No	0	9	9
43	R:R:L89	R:R:T85	4.42	No	No	0	7	9
44	R:R:A110	R:R:T85	3.36	No	No	0	9	9
45	R:R:E166	R:R:T101	4.23	Yes	No	0	9	6
46	R:R:M181	R:R:T101	4.52	No	No	0	6	6
47	R:R:T101	R:R:T186	7.85	No	No	0	6	7
48	R:R:H103	R:R:V102	4.15	No	No	0	8	8
49	R:R:E166	R:R:V102	8.56	Yes	No	2	9	8
50	R:R:R167	R:R:V102	6.54	Yes	No	2	9	8
51	R:R:H103	W:W:?1	7.03	No	Yes	0	8	0
52	R:R:R183	R:R:Y104	10.29	No	No	0	4	4
53	R:R:T186	R:R:Y104	3.75	No	No	0	7	4
54	R:R:E166	R:R:H105	6.15	Yes	No	0	9	8
55	R:R:H105	R:R:I190	6.63	No	No	0	8	7
56	R:R:L106	R:R:L163	4.15	No	No	2	8	9
57	R:R:L106	R:R:Y369	26.96	No	Yes	2	8	9
58	R:R:L106	W:W:?1	5.67	No	Yes	2	8	0
59	R:R:N159	R:R:S108	7.45	No	No	0	8	9
60	R:R:S108	R:R:W194	6.18	No	No	0	9	9
61	R:R:L109	R:R:N159	4.12	No	No	0	9	8
62	R:R:L109	R:R:V160	4.47	No	No	0	9	8
63	R:R:L109	R:R:Y369	4.69	No	Yes	0	9	9
64	R:R:L111	R:R:L115	4.15	No	No	0	6	6
65	R:R:A155	R:R:S112	3.42	No	No	4	7	8
66	R:R:S112	R:R:T156	4.8	No	No	0	8	9
67	R:R:S112	R:R:W194	3.71	No	No	4	8	9
68	R:R:D113	R:R:S362	11.78	No	No	0	9	9
69	R:R:D113	R:R:N365	6.73	No	No	0	9	9
70	R:R:L114	R:R:L118	8.3	No	No	0	8	5
71	R:R:C152	R:R:I116	4.91	No	No	0	7	7
72	R:R:F358	R:R:I116	3.77	Yes	No	0	7	7
73	R:R:L117	R:R:S362	4.5	No	No	0	6	9
74	R:R:L119	R:R:L148	8.3	No	No	0	5	5
75	R:R:A120	R:R:Y145	4	No	No	0	6	6
76	R:R:A120	R:R:Y359	4	No	Yes	0	6	7
77	R:R:M121	R:R:P122	3.35	Yes	No	0	7	9
78	R:R:M121	R:R:Y359	13.17	Yes	Yes	0	7	7
79	R:R:V123	R:R:Y145	11.36	No	No	0	5	6
80	R:R:E124	R:R:F128	8.16	Yes	Yes	1	7	6
81	R:R:E124	R:R:Y145	6.73	Yes	No	0	7	6
82	R:R:E124	R:R:R149	12.79	Yes	Yes	1	7	7
83	R:R:E124	R:R:Y351	8.98	Yes	Yes	1	7	4
84	R:R:E124	R:R:N355	9.2	Yes	Yes	1	7	6
85	R:R:E124	R:R:Y359	5.61	Yes	Yes	1	7	7
86	R:R:I129	R:R:L125	4.28	No	No	1	5	6
87	R:R:N127	R:R:Y126	3.49	Yes	No	0	5	4
88	R:R:V131	R:R:Y126	6.31	No	No	0	5	4
89	R:R:F128	R:R:N127	3.62	Yes	Yes	1	6	5
90	R:R:N127	R:R:W135	13.56	Yes	Yes	1	5	9
91	R:R:A136	R:R:N127	4.69	No	Yes	0	4	5
92	R:R:F128	R:R:W135	4.01	Yes	Yes	1	6	9
93	R:R:F128	R:R:Y146	5.16	Yes	Yes	0	6	5
94	R:R:F128	R:R:Y351	8.25	Yes	Yes	1	6	4
95	R:R:H132	R:R:H348	11.94	No	Yes	3	5	4
96	R:R:G221	R:R:P134	6.09	No	No	0	4	5
97	R:R:C142	R:R:W135	7.84	No	Yes	1	9	9
98	R:R:C225	R:R:W135	11.75	No	Yes	1	9	9
99	R:R:G138	R:R:L210	5.13	No	No	0	8	5
100	R:R:D139	R:R:R143	7.15	No	No	0	3	7
101	R:R:D139	R:R:G209	3.35	No	No	0	3	3
102	R:R:D139	R:R:L210	5.43	No	No	0	3	5
103	R:R:C142	R:R:C225	7.28	No	No	1	9	9
104	R:R:L205	R:R:R143	9.72	No	No	0	5	7
105	R:R:M204	R:R:Y146	5.99	No	Yes	0	6	5
106	R:R:M208	R:R:Y146	10.78	No	Yes	0	5	5
107	R:R:C225	R:R:Y146	5.38	No	Yes	0	9	5
108	R:R:F147	R:R:L205	8.53	Yes	No	0	5	5
109	R:R:R149	R:R:Y324	11.32	Yes	Yes	1	7	5
110	R:R:F358	R:R:R149	5.34	Yes	Yes	1	7	7
111	R:R:R149	R:R:Y359	8.23	Yes	Yes	1	7	7
112	R:R:D150	R:R:M204	9.7	No	No	0	6	6
113	R:R:D150	R:R:R328	3.57	No	Yes	0	6	6
114	R:R:F358	R:R:T153	7.78	Yes	No	0	7	7
115	R:R:L200	R:R:Y154	16.41	No	No	0	5	6
116	R:R:N241	R:R:Y154	11.63	No	No	5	5	6
117	R:R:S245	R:R:Y154	3.82	No	No	5	6	6
118	R:R:A155	R:R:W194	5.19	No	No	4	7	9
119	R:R:A155	R:R:S197	3.42	No	No	0	7	8
120	R:R:T156	R:R:W321	4.85	No	Yes	0	9	8
121	R:R:A157	R:R:P249	3.74	No	No	0	7	9
122	R:R:L158	R:R:S197	6.01	No	No	0	7	8
123	R:R:I193	R:R:N159	7.08	No	No	0	8	8
124	R:R:I253	R:R:V160	4.61	Yes	No	0	8	8
125	R:R:A161	R:R:I253	3.25	No	Yes	0	7	8
126	R:R:F189	R:R:S162	9.25	No	No	0	5	7
127	R:R:L163	R:R:Y369	3.52	No	Yes	2	9	9
128	R:R:L163	W:W:?1	13.24	No	Yes	2	9	0
129	R:R:I253	R:R:S164	4.64	Yes	Yes	0	8	9
130	R:R:N257	R:R:S164	5.96	Yes	Yes	2	9	9
131	R:R:S164	W:W:?1	4.1	Yes	Yes	2	9	0
132	R:R:E166	R:R:R167	12.79	Yes	Yes	2	9	9
133	R:R:R167	W:W:?1	20.75	Yes	Yes	2	9	0
134	R:R:L169	R:R:Y168	3.52	No	Yes	0	4	8
135	R:R:C172	R:R:Y168	9.41	No	Yes	6	7	8
136	R:R:H173	R:R:Y168	7.62	No	Yes	6	6	8
137	R:R:L256	R:R:Y168	10.55	Yes	Yes	0	7	8
138	R:R:V259	R:R:Y168	3.79	No	Yes	0	5	8
139	R:R:I260	R:R:Y168	3.63	No	Yes	0	8	8
140	R:R:I171	R:R:L264	4.28	No	No	0	8	8
141	R:R:C172	R:R:H173	4.42	No	No	6	7	6
142	R:R:C172	R:R:K263	3.23	No	No	0	7	5
143	R:R:K188	R:R:R185	9.9	No	No	0	3	6
144	R:R:K187	R:R:S191	4.59	No	No	0	4	3
145	R:R:F189	R:R:I193	5.02	No	No	0	5	8
146	R:R:L195	R:R:L199	4.15	No	No	0	3	4
147	R:R:I202	R:R:L199	5.71	No	No	0	4	4
148	R:R:L200	R:R:M244	4.24	No	No	0	5	4
149	R:R:I202	R:R:P203	3.39	No	No	0	4	8
150	R:R:F206	R:R:T207	5.19	No	No	0	4	4
151	R:R:T207	R:R:V237	4.76	No	No	0	4	7
152	R:R:M208	R:R:P227	8.39	No	Yes	1	5	5
153	R:R:G209	R:R:I228	5.29	No	No	0	3	3
154	R:R:L210	R:R:L223	9.69	No	No	0	5	3
155	R:R:Q211	R:R:T226	7.09	No	No	0	3	3
156	R:R:N212	R:R:T218	5.85	No	No	0	2	2
157	R:R:G222	R:R:N212	3.39	No	No	0	2	2
158	R:R:L223	R:R:N212	6.87	No	No	0	3	2
159	R:R:H219	R:R:S214	4.18	Yes	No	0	3	4
160	R:R:H219	R:R:P220	12.2	Yes	No	0	3	3
161	R:R:P227	R:R:T226	6.99	Yes	No	0	5	3
162	R:R:P227	R:R:V234	5.3	Yes	No	0	5	5
163	R:R:F331	R:R:P227	5.78	No	Yes	1	3	5
164	R:R:T233	R:R:V229	6.35	No	No	0	4	5
165	R:R:C332	R:R:V234	3.42	No	No	0	4	5
166	R:R:K235	R:R:Y333	15.53	No	Yes	0	4	5
167	R:R:I238	R:R:R328	8.77	Yes	Yes	0	5	6
168	R:R:I238	R:R:L329	4.28	Yes	No	7	5	5
169	R:R:C332	R:R:I238	6.55	No	Yes	0	4	5
170	R:R:I238	R:R:Y333	3.63	Yes	Yes	7	5	5
171	R:R:N241	R:R:S245	4.47	No	No	5	5	6
172	R:R:N241	R:R:R328	8.44	No	Yes	0	5	6
173	R:R:H325	R:R:T242	8.21	Yes	No	0	7	5
174	R:R:L329	R:R:T242	5.9	No	No	0	5	5
175	R:R:F243	R:R:M244	3.73	No	No	0	4	4
176	R:R:H325	R:R:S245	5.58	Yes	No	0	7	6
177	R:R:F246	R:R:L247	3.65	Yes	No	0	8	5
178	R:R:F246	R:R:M250	4.98	Yes	No	0	8	7
179	R:R:F246	R:R:L322	6.09	Yes	No	0	8	6
180	R:R:F246	R:R:H325	5.66	Yes	Yes	0	8	7
181	R:R:F248	R:R:P249	4.33	No	No	0	5	9
182	R:R:F317	R:R:M250	8.71	No	No	0	9	7
183	R:R:M250	R:R:V318	7.61	No	No	0	7	6
184	R:R:I255	R:R:L251	7.14	No	No	0	4	3
185	R:R:F317	R:R:I253	3.77	No	Yes	0	9	8
186	R:R:S254	R:R:V314	3.23	No	No	0	5	8
187	R:R:L310	R:R:N257	6.87	No	Yes	2	8	9
188	R:R:N257	R:R:V314	4.43	Yes	No	0	9	8
189	R:R:N257	W:W:?1	3.75	Yes	Yes	2	9	0
190	R:R:V309	R:R:V372	4.81	No	No	0	8	7
191	R:R:L310	W:W:?1	7.57	No	Yes	2	8	0
192	R:R:I315	R:R:R311	13.78	No	No	0	5	5
193	R:R:V313	W:W:?1	12.21	No	Yes	0	8	0
194	R:R:F317	R:R:W321	20.04	No	Yes	0	9	8
195	R:R:C320	R:R:S361	6.89	No	No	0	8	9
196	R:R:S361	R:R:W321	4.94	No	Yes	0	9	8
197	R:R:L322	R:R:P323	3.28	No	No	0	6	9
198	R:R:P323	R:R:T354	3.5	No	No	0	9	5
199	R:R:L357	R:R:P323	3.28	No	No	0	7	9
200	R:R:H325	R:R:Y324	6.53	Yes	Yes	0	7	5
201	R:R:R327	R:R:Y324	6.17	Yes	Yes	1	5	5
202	R:R:R328	R:R:Y324	17.49	Yes	Yes	0	6	5
203	R:R:F358	R:R:Y324	5.16	Yes	Yes	1	7	5
204	R:R:R327	R:R:Y347	9.26	Yes	Yes	1	5	4
205	R:R:F350	R:R:R327	6.41	Yes	Yes	1	5	5
206	R:R:R327	R:R:Y351	15.43	Yes	Yes	1	5	4
207	R:R:R327	R:R:T354	6.47	Yes	No	1	5	5
208	R:R:N355	R:R:R327	3.62	Yes	Yes	1	6	5
209	R:R:L329	R:R:Y333	3.52	No	Yes	7	5	5
210	R:R:I334	R:R:M330	4.37	No	No	0	3	5
211	R:R:F350	R:R:M330	3.73	Yes	No	0	5	5
212	R:R:F331	R:R:Y347	7.22	No	Yes	1	3	4
213	R:R:I334	R:R:W339	19.97	No	Yes	0	3	7
214	R:R:E337	R:R:S335	10.06	No	No	0	2	3
215	R:R:Q338	R:R:S335	10.11	No	No	0	1	3
216	R:R:D336	R:R:E337	12.99	No	No	0	2	2
217	R:R:L343	R:R:W339	7.97	No	Yes	0	2	7
218	R:R:W339	R:R:Y347	4.82	Yes	Yes	1	7	4
219	R:R:D345	R:R:F344	3.58	No	Yes	0	3	3
220	R:R:F346	R:R:F350	4.29	No	Yes	0	4	5
221	R:R:H348	R:R:M352	6.57	Yes	No	0	4	4
222	R:R:M352	R:R:Y349	4.79	No	No	0	4	1
223	R:R:F350	R:R:T354	7.78	Yes	No	1	5	5
224	R:R:N355	R:R:Y351	12.79	Yes	Yes	1	6	4
225	R:R:I364	R:R:L368	5.71	No	No	0	6	8
226	R:R:Y369	W:W:?1	10.41	Yes	Yes	2	9	0
227	R:R:T265	R:R:V307	3.17	No	No	0	5	7
228	R:R:A110	R:R:L86	3.15	No	No	0	9	7
229	R:R:I116	R:R:S362	3.1	No	No	0	7	9
230	R:R:H133	R:R:P134	3.05	No	No	0	5	5
231	R:R:M330	R:R:V326	3.04	No	No	0	5	5
232	R:R:F137	R:R:W135	3.01	No	Yes	0	7	9
233	R:R:F137	R:R:G141	3.01	No	No	0	7	4
234	R:R:L256	R:R:S164	3	Yes	Yes	0	7	9
235	R:R:N52	R:R:S53	2.98	No	No	0	3	5
236	R:R:L256	R:R:V165	2.98	Yes	No	0	7	6
237	R:R:L256	R:R:V252	2.98	Yes	No	0	7	5
238	R:R:L264	R:R:V307	2.98	No	No	0	8	7
239	R:R:L72	R:R:T68	2.95	No	No	0	3	6
240	R:R:I171	W:W:?1	2.93	No	Yes	0	8	0
241	R:R:F206	R:R:P203	2.89	No	No	0	4	8
242	R:R:I70	R:R:L66	2.85	No	No	0	4	5
243	R:R:I367	R:R:L368	2.85	No	No	0	7	8
244	R:R:G138	R:R:W135	2.81	No	Yes	0	8	9
245	R:R:L111	R:R:L86	2.77	No	No	0	6	7
246	R:R:L114	R:R:L86	2.77	No	No	0	8	7
247	R:R:L115	R:R:L119	2.77	No	No	0	6	5
248	R:R:A201	R:R:F147	2.77	No	Yes	0	7	5
249	R:R:L114	R:R:N82	2.75	No	Yes	0	8	9
250	R:R:I334	R:R:Q338	2.74	No	No	0	3	1
251	R:R:D54	R:R:L55	2.71	No	No	0	4	2
252	R:R:D345	R:R:N58	2.69	No	No	0	3	3
253	R:R:A157	R:R:W321	2.59	No	Yes	0	7	8
254	R:R:D56	R:R:H132	2.52	No	No	0	2	5
255	R:R:D56	R:R:H133	2.52	No	No	0	2	5
256	R:R:V65	R:R:Y62	2.52	No	No	0	5	3
257	R:R:F175	R:R:K176	2.48	No	No	0	6	5
258	R:R:I70	R:R:Y71	2.42	No	Yes	0	4	7
259	R:R:Q239	R:R:Y333	2.25	No	Yes	0	6	5
260	R:R:F189	R:R:R185	2.14	No	No	0	5	6
261	R:R:V309	W:W:?1	2.04	No	Yes	0	8	0
262	R:R:A363	R:R:G78	1.95	No	No	0	6	8
263	R:R:A110	R:R:G107	1.95	No	No	0	9	5
264	R:R:A140	R:R:G141	1.95	No	No	0	1	4
265	R:R:G78	R:R:V77	1.84	No	No	0	8	5
266	R:R:G81	R:R:V80	1.84	No	No	0	8	4
267	R:R:A151	R:R:A201	1.79	No	No	0	5	7
268	R:R:P227	R:R:T207	1.75	Yes	No	0	5	4
269	R:R:G78	R:R:L117	1.71	No	No	0	8	6
270	R:R:A215	R:R:S214	1.71	No	No	0	1	4
271	R:R:A261	R:R:V307	1.7	No	No	0	6	7
272	R:R:I367	R:R:P366	1.69	No	No	0	7	9
273	R:R:D216	R:R:G217	1.68	No	No	0	3	2
274	R:R:S182	R:R:S184	1.63	No	No	0	7	4
275	R:R:V76	R:R:V77	1.6	No	No	0	5	5
276	R:R:V80	R:R:V84	1.6	No	No	0	4	6
277	R:R:V229	R:R:V234	1.6	No	No	0	5	5
278	R:R:V236	R:R:V240	1.6	No	No	0	4	4
279	R:R:S254	R:R:T258	1.6	No	No	0	5	1
280	R:R:T88	R:R:V84	1.59	No	No	0	7	6
281	R:R:G221	R:R:H219	1.59	No	Yes	0	4	3
282	R:R:G306	R:R:H305	1.59	No	No	0	8	8
283	R:R:A73	R:R:L74	1.58	No	No	0	4	7
284	R:R:A196	R:R:L158	1.58	No	No	0	5	7
285	R:R:A177	R:R:L169	1.58	No	No	0	6	4
286	R:R:A215	R:R:D216	1.54	No	No	0	1	3
287	R:R:I315	R:R:V319	1.54	No	No	0	5	5
288	R:R:H173	R:R:P174	1.53	No	No	0	6	9
289	R:R:K188	R:R:S184	1.53	No	No	0	3	4
290	R:R:F147	R:R:G144	1.51	Yes	No	0	5	4
291	R:R:K178	R:R:T179	1.5	No	No	0	4	4
292	R:R:N375	R:R:S373	1.49	No	No	0	7	8
293	R:R:L180	R:R:T179	1.47	No	No	0	5	4
294	R:R:L343	R:R:T340	1.47	No	No	0	2	7
295	R:R:N370	R:R:T85	1.46	No	No	0	7	9
296	R:R:N262	R:R:T258	1.46	No	No	0	5	1
297	R:R:D230	R:R:T233	1.45	No	No	0	4	4
298	R:R:D345	R:R:T341	1.45	No	No	0	3	4
299	R:R:F175	R:R:P174	1.44	No	No	0	6	9
300	R:R:K187	R:R:K188	1.44	No	No	0	4	3
301	R:R:K176	R:R:L180	1.41	No	No	0	5	5
302	R:R:L264	R:R:M267	1.41	No	No	0	8	6
303	R:R:L303	R:R:M267	1.41	No	No	0	8	6
304	R:R:A198	R:R:F147	1.39	No	Yes	0	2	5
305	R:R:A170	R:R:R167	1.38	No	Yes	0	8	9
306	R:R:H305	R:R:V372	1.38	No	No	0	8	7
307	R:R:R183	R:R:S100	1.32	No	No	0	4	7
308	R:R:F342	R:R:T340	1.3	No	No	0	3	7
309	L:L:R9	R:R:T231	1.29	No	No	0	0	1
310	R:R:L308	R:R:R304	1.21	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L13	5.678	5	1	0
2	R:R:Y71	5.425	6	1	7
3	R:R:N82	5.8425	4	0	9
4	R:R:M121	7.205	4	0	7
5	R:R:E124	8.57833	6	1	7
6	R:R:N127	6.34	4	1	5
7	R:R:F128	7.37833	6	1	6
8	R:R:W135	7.16333	6	1	9
9	R:R:Y146	6.8275	4	0	5
10	R:R:F147	3.55	4	0	5
11	R:R:R149	9.42	4	1	7
12	R:R:S164	4.425	4	2	9
13	R:R:E166	7.9325	4	2	9
14	R:R:R167	10.365	4	2	9
15	R:R:Y168	6.42	6	6	8
16	R:R:H219	10.55	4	0	3
17	R:R:P227	5.24833	6	1	5
18	R:R:I238	5.8075	4	7	5
19	R:R:F246	5.095	4	0	8
20	R:R:I253	4.0675	4	0	8
21	R:R:L256	4.8775	4	0	7
22	R:R:N257	5.2525	4	2	9
23	R:R:W321	8.105	4	0	8
24	R:R:Y324	9.334	5	1	5
25	R:R:H325	6.495	4	0	7
26	R:R:R327	7.28571	7	1	5
27	R:R:R328	8.626	5	0	6
28	R:R:Y333	6.2325	4	7	5
29	R:R:W339	10.184	5	1	7
30	R:R:F344	7.915	4	0	3
31	R:R:Y347	8.1075	4	1	4
32	R:R:H348	8.42	4	3	4
33	R:R:F350	5.5525	4	1	5
34	R:R:Y351	9.816	5	1	4
35	R:R:N355	7.855	4	1	6
36	R:R:F358	5.5125	4	1	7
37	R:R:Y359	7.7525	4	1	7
38	R:R:Y369	11.395	4	2	9
39	W:W:?1	8.15454	11	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R8	R:R:F344	18.4183	7.48	No	Yes	0	0	3
2	L:L:P10	R:R:F344	57.0494	10.11	No	Yes	0	0	3
3	L:L:P10	R:R:Y347	55.4275	11.13	No	Yes	1	0	4
4	R:R:R327	R:R:Y351	28.5548	15.43	Yes	Yes	1	5	4
5	R:R:R327	R:R:Y347	60.6825	9.26	Yes	Yes	1	5	4
6	R:R:F128	R:R:Y351	23.4886	8.25	Yes	Yes	1	6	4
7	L:L:L13	R:R:R327	20.3493	3.64	Yes	Yes	1	0	5
8	L:L:L13	R:R:R328	22.3645	4.86	Yes	Yes	0	0	6
9	R:R:R327	R:R:Y324	79.723	6.17	Yes	Yes	1	5	5
10	R:R:R328	R:R:Y324	25.9574	17.49	Yes	Yes	0	6	5
11	L:L:R8	R:R:D54	17.1578	7.15	No	No	0	0	4
12	R:R:D54	R:R:L55	16.0096	2.71	No	No	0	4	2
13	R:R:H133	R:R:L55	13.8619	15.43	No	No	0	5	2
14	R:R:H133	R:R:P134	25.7688	3.05	No	No	0	5	5
15	R:R:G221	R:R:P134	23.2276	6.09	No	No	0	4	5
16	R:R:G221	R:R:H219	20.6784	1.59	No	Yes	0	4	3
17	R:R:F344	R:R:V57	34.6728	10.49	Yes	No	0	3	2
18	R:R:H132	R:R:V57	16.2465	5.54	No	No	3	5	2
19	R:R:H348	R:R:V57	17.4548	9.69	Yes	No	3	4	2
20	R:R:H348	R:R:M352	10.5861	6.57	Yes	No	0	4	4
21	R:R:N355	R:R:R327	13.2919	3.62	Yes	Yes	1	6	5
22	R:R:N355	R:R:Y71	14.1108	5.81	Yes	Yes	1	6	7
23	R:R:F358	R:R:Y324	51.5817	5.16	Yes	Yes	1	7	5
24	R:R:F358	R:R:I116	63.1674	3.77	Yes	No	0	7	7
25	R:R:I116	R:R:S362	61.1281	3.1	No	No	0	7	9
26	R:R:D113	R:R:S362	28.2377	11.78	No	No	0	9	9
27	R:R:D113	R:R:N82	25.9414	6.73	No	Yes	0	9	9
28	R:R:N82	R:R:P366	20.3573	9.77	Yes	No	0	9	9
29	R:R:G81	R:R:P366	10.2409	4.06	No	No	0	8	9
30	R:R:L117	R:R:S362	31.935	4.5	No	No	0	6	9
31	R:R:L117	R:R:N82	26.1943	4.12	No	Yes	0	6	9
32	R:R:L114	R:R:N82	30.0562	2.75	No	Yes	0	8	9
33	R:R:L114	R:R:L86	25.0783	2.77	No	No	0	8	7
34	R:R:A110	R:R:L86	12.493	3.15	No	No	0	9	7
35	R:R:H325	R:R:Y324	97.5391	6.53	Yes	Yes	0	7	5
36	R:R:F246	R:R:H325	97.3866	5.66	Yes	Yes	0	8	7
37	R:R:F246	R:R:M250	100	4.98	Yes	No	0	8	7
38	R:R:F317	R:R:M250	98.3701	8.71	No	No	0	9	7
39	R:R:F317	R:R:I253	83.6933	3.77	No	Yes	0	9	8
40	R:R:I253	R:R:S164	66.2104	4.64	Yes	Yes	0	8	9
41	R:R:S164	W:W:?1	38.8238	4.1	Yes	Yes	2	9	0
42	R:R:R167	W:W:?1	16.3228	20.75	Yes	Yes	2	9	0
43	R:R:E166	R:R:R167	12.3926	12.79	Yes	Yes	2	9	9
44	R:R:I253	R:R:V160	17.8884	4.61	Yes	No	0	8	8
45	R:R:L109	R:R:V160	16.664	4.47	No	No	0	9	8
46	R:R:L109	R:R:N159	17.5432	4.12	No	No	0	9	8
47	R:R:F317	R:R:W321	19.0365	20.04	No	Yes	0	9	8
48	R:R:T156	R:R:W321	10.7507	4.85	No	Yes	0	9	8
49	R:R:L111	R:R:L86	10.2409	2.77	No	No	0	6	7
50	R:R:R149	R:R:Y324	18.065	11.32	Yes	Yes	1	7	5
51	R:R:F128	R:R:W135	37.5191	4.01	Yes	Yes	1	6	9
52	R:R:G138	R:R:W135	31.7262	2.81	No	Yes	0	8	9
53	R:R:G138	R:R:L210	29.8033	5.13	No	No	0	8	5
54	R:R:D139	R:R:L210	20.0682	5.43	No	No	0	3	5
55	R:R:D139	R:R:R143	14.1309	7.15	No	No	0	3	7
56	R:R:L205	R:R:R143	12.1357	9.72	No	No	0	5	7
57	R:R:F147	R:R:L205	10.1325	8.53	Yes	No	0	5	5
58	R:R:N241	R:R:R328	10.0682	8.44	No	Yes	0	5	6
59	R:R:I193	R:R:N159	14.0506	7.08	No	No	0	8	8
60	R:R:F189	R:R:I193	12.5211	5.02	No	No	0	5	8
61	R:R:L256	R:R:S164	25.1987	3	Yes	Yes	0	7	9
62	R:R:L256	R:R:Y168	20.8872	10.55	Yes	Yes	0	7	8
63	R:R:H173	R:R:Y168	10.6744	7.62	No	Yes	6	6	8
64	R:R:P227	R:R:T207	13.6813	1.75	Yes	No	0	5	4
65	R:R:H219	R:R:S214	10.4014	4.18	Yes	No	0	3	4
66	R:R:I238	R:R:R328	13.621	8.77	Yes	Yes	0	5	6
67	R:R:I334	R:R:Q338	11.0116	2.74	No	No	0	3	1
68	R:R:D56	R:R:H133	14.5765	2.52	No	No	0	2	5
69	R:R:D56	R:R:H132	15.829	2.52	No	No	0	2	5
70	R:R:W339	R:R:Y347	12.6335	4.82	Yes	Yes	1	7	4
71	L:L:L13	R:R:P227	19.7953	3.28	Yes	Yes	1	0	5
72	R:R:E124	R:R:F128	21.9992	8.16	Yes	Yes	1	7	6
73	R:R:E124	R:R:R149	24.0586	12.79	Yes	Yes	1	7	7
74	R:R:F358	R:R:R149	13.5889	5.34	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R8	R:R:D54	7.15	0	No	No	0	4	0	1
L:L:R8	R:R:F344	7.48	0	No	Yes	0	3	0	1
L:L:R9	R:R:W339	6	0	No	Yes	0	7	0	1
L:L:P10	R:R:W339	12.16	1	No	Yes	0	7	0	1
L:L:P10	R:R:F344	10.11	1	No	Yes	0	3	0	1
L:L:P10	R:R:Y347	11.13	1	No	Yes	0	4	0	1
L:L:Y11	R:R:V224	12.62	0	No	No	0	5	0	1
L:L:I12	R:R:F128	15.07	1	No	Yes	0	6	0	1
L:L:I12	R:R:Y351	3.63	1	No	Yes	0	4	0	1
L:L:L13	R:R:M208	5.65	1	Yes	No	0	5	0	1
L:L:L13	R:R:P227	3.28	1	Yes	Yes	0	5	0	1
L:L:L13	R:R:R327	3.64	1	Yes	Yes	0	5	0	1
L:L:L13	R:R:R328	4.86	1	Yes	Yes	0	6	0	1
L:L:L13	R:R:F331	10.96	1	Yes	No	0	3	0	1
R:R:F344	R:R:V57	10.49	0	Yes	No	3	2	1	2
R:R:E124	R:R:F128	8.16	1	Yes	Yes	7	6	2	1
R:R:E124	R:R:Y351	8.98	1	Yes	Yes	7	4	2	1
R:R:E124	R:R:N355	9.2	1	Yes	Yes	7	6	2	2
R:R:F128	R:R:N127	3.62	1	Yes	Yes	6	5	1	2
R:R:N127	R:R:W135	13.56	1	Yes	Yes	5	9	2	2
R:R:F128	R:R:W135	4.01	1	Yes	Yes	6	9	1	2
R:R:F128	R:R:Y146	5.16	1	Yes	Yes	6	5	1	2
R:R:F128	R:R:Y351	8.25	1	Yes	Yes	6	4	1	1
R:R:M208	R:R:Y146	10.78	1	No	Yes	5	5	1	2
R:R:D150	R:R:R328	3.57	0	No	Yes	6	6	2	1
R:R:M208	R:R:P227	8.39	1	No	Yes	5	5	1	1
R:R:P227	R:R:T226	6.99	1	Yes	No	5	3	1	2
R:R:P227	R:R:V234	5.3	1	Yes	No	5	5	1	2
R:R:F331	R:R:P227	5.78	1	No	Yes	3	5	1	1
R:R:I238	R:R:R328	8.77	7	Yes	Yes	5	6	2	1
R:R:N241	R:R:R328	8.44	5	No	Yes	5	6	2	1
R:R:R327	R:R:Y324	6.17	1	Yes	Yes	5	5	1	2
R:R:R328	R:R:Y324	17.49	0	Yes	Yes	6	5	1	2
R:R:R327	R:R:Y347	9.26	1	Yes	Yes	5	4	1	1
R:R:F350	R:R:R327	6.41	1	Yes	Yes	5	5	2	1
R:R:R327	R:R:Y351	15.43	1	Yes	Yes	5	4	1	1
R:R:R327	R:R:T354	6.47	1	Yes	No	5	5	1	2
R:R:N355	R:R:R327	3.62	1	Yes	Yes	6	5	2	1
R:R:F331	R:R:Y347	7.22	1	No	Yes	3	4	1	1
R:R:I334	R:R:W339	19.97	0	No	Yes	3	7	2	1
R:R:L343	R:R:W339	7.97	0	No	Yes	2	7	2	1
R:R:W339	R:R:Y347	4.82	1	Yes	Yes	7	4	1	1
R:R:D345	R:R:F344	3.58	0	No	Yes	3	3	2	1
R:R:F350	R:R:T354	7.78	1	Yes	No	5	5	2	2
R:R:N355	R:R:Y351	12.79	1	Yes	Yes	6	4	2	1
R:R:D54	R:R:L55	2.71	0	No	No	4	2	1	2
R:R:P227	R:R:T207	1.75	1	Yes	No	5	4	1	2
L:L:R9	R:R:T231	1.29	0	No	No	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H103	R:R:V102	4.15	0	No	No	8	8	1	2
R:R:E166	R:R:V102	8.56	2	Yes	No	9	8	2	2
R:R:R167	R:R:V102	6.54	2	Yes	No	9	8	1	2
R:R:H103	W:W:?1	7.03	0	No	Yes	8	0	1	0
R:R:L106	R:R:L163	4.15	2	No	No	8	9	1	1
R:R:L106	R:R:Y369	26.96	2	No	Yes	8	9	1	1
R:R:L106	W:W:?1	5.67	2	No	Yes	8	0	1	0
R:R:L109	R:R:Y369	4.69	0	No	Yes	9	9	2	1
R:R:L163	R:R:Y369	3.52	2	No	Yes	9	9	1	1
R:R:L163	W:W:?1	13.24	2	No	Yes	9	0	1	0
R:R:I253	R:R:S164	4.64	0	Yes	Yes	8	9	2	1
R:R:N257	R:R:S164	5.96	2	Yes	Yes	9	9	1	1
R:R:S164	W:W:?1	4.1	2	Yes	Yes	9	0	1	0
R:R:E166	R:R:R167	12.79	2	Yes	Yes	9	9	2	1
R:R:R167	W:W:?1	20.75	2	Yes	Yes	9	0	1	0
R:R:I171	R:R:L264	4.28	0	No	No	8	8	1	2
R:R:L310	R:R:N257	6.87	2	No	Yes	8	9	1	1
R:R:N257	R:R:V314	4.43	2	Yes	No	9	8	1	2
R:R:N257	W:W:?1	3.75	2	Yes	Yes	9	0	1	0
R:R:V309	R:R:V372	4.81	0	No	No	8	7	1	2
R:R:L310	W:W:?1	7.57	2	No	Yes	8	0	1	0
R:R:V313	W:W:?1	12.21	0	No	Yes	8	0	1	0
R:R:Y369	W:W:?1	10.41	2	Yes	Yes	9	0	1	0
R:R:L256	R:R:S164	3	0	Yes	Yes	7	9	2	1
R:R:I171	W:W:?1	2.93	0	No	Yes	8	0	1	0
R:R:V309	W:W:?1	2.04	0	No	Yes	8	0	1	0
R:R:A170	R:R:R167	1.38	0	No	Yes	8	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FN0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	274
Number of Links	310
Number of Hubs	39
Number of Links mediated by Hubs	142
Number of Communities	7
Number of Nodes involved in Communities	51
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	60080
Length Of Smallest Path	3
Average Path Length	13.418
Length of Longest Path	31
Minimum Path Strength	1.385
Average Path Strength	6.3659
Maximum Path Strength	18.215
Minimum Path Correlation	0.7
Average Path Correlation	0.921102
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	48.4753
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.6402
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of locomotion • regulation of biological process • regulation of locomotion • biological regulation • positive regulation of biological process • locomotion • behavior • multicellular organismal process • system process • learning • learning or memory • nervous system process • cognition • cellular response to stimulus • regulation of postsynaptic membrane potential • regulation of cellular process • response to stimulus • signaling • regulation of system process • regulation of signal transduction • chemical synaptic transmission, postsynaptic • cell communication • synaptic signaling • positive regulation of inhibitory postsynaptic potential • positive regulation of nervous system process • regulation of multicellular organismal process • signal transduction • regulation of biological quality • modulation of inhibitory postsynaptic potential • trans-synaptic signaling • regulation of signaling • cell surface receptor signaling pathway • cell-cell signaling • regulation of nervous system process • chemical synaptic transmission • regulation of response to stimulus • anterograde trans-synaptic signaling • inhibitory postsynaptic potential • positive regulation of multicellular organismal process • regulation of cell communication • cellular process • regulation of membrane potential • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • regulation of localization • positive regulation of arachidonate secretion • transport • regulation of lipid transport • regulation of arachidonate secretion • localization • arachidonate secretion • monocarboxylic acid transport • positive regulation of secretion • fatty acid transport • icosanoid transport • regulation of icosanoid secretion • icosanoid secretion • long-chain fatty acid transport • positive regulation of icosanoid secretion • organic anion transport • carboxylic acid transport • secretion • arachidonate transport • regulation of transport • lipid localization • lipid transport • positive regulation of lipid localization • establishment of localization • regulation of fatty acid transport • regulation of secretion • positive regulation of organic acid transport • organic acid transport • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • alcohol catabolic process • catabolic process • polyol catabolic process • organophosphate catabolic process • inositol phosphate catabolic process • small molecule catabolic process • detection of external stimulus • detection of stimulus involved in sensory perception of pain • response to external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • L-glutamate import across plasma membrane • import into cell • nitrogen compound transport • carboxylic acid transmembrane transport • import across plasma membrane • amino acid transmembrane transport • L-amino acid transport • L-glutamate import • transmembrane transport • amino acid transport • acidic amino acid transport • dicarboxylic acid transport • L-alpha-amino acid transmembrane transport • amino acid import across plasma membrane • L-glutamate transmembrane transport • ribose phosphate metabolic process • nucleotide biosynthetic process • carbohydrate derivative metabolic process • purine ribonucleotide biosynthetic process • cAMP biosynthetic process • cyclic nucleotide metabolic process • nucleobase-containing compound metabolic process • ribonucleotide biosynthetic process • purine nucleotide metabolic process • ribonucleotide metabolic process • nucleobase-containing small molecule metabolic process • purine-containing compound biosynthetic process • cyclic nucleotide biosynthetic process • ribose phosphate biosynthetic process • nucleoside phosphate metabolic process • carbohydrate derivative biosynthetic process • cAMP metabolic process • cyclic purine nucleotide metabolic process • nucleotide metabolic process • nucleobase-containing compound biosynthetic process • purine-containing compound metabolic process • nucleoside phosphate biosynthetic process • purine ribonucleotide metabolic process • purine nucleotide biosynthetic process • conditioned place preference • associative learning • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • response to lipid • response to chemical • positive regulation of phosphate metabolic process • positive regulation of phosphorus metabolic process • positive regulation of inositol phosphate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • adult locomotory behavior • adult behavior • locomotory behavior • regulation of calcium ion transport • intracellular calcium ion homeostasis • negative regulation of biological process • negative regulation of transport • calcium ion transport • negative regulation of cation transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • maintenance of location • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • negative regulation of calcium ion transmembrane transport • cellular localization • inorganic ion homeostasis • homeostatic process • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • negative regulation of transmembrane transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of sequestering of calcium ion • negative regulation of monoatomic ion transmembrane transport • negative regulation of release of sequestered calcium ion into cytosol • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • negative regulation of cellular process • monoatomic ion transport • intracellular chemical homeostasis • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • negative regulation of calcium ion transport • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of programmed cell death • negative regulation of apoptotic process • regulation of defense response • behavioral fear response • defense response • regulation of fear response • multicellular organismal response to stress • regulation of behavioral fear response • regulation of behavior • behavioral defense response • fear response • regulation of response to stress • response to stress • aspartate transmembrane transport • C4-dicarboxylate transport • D-amino acid transport • D-aspartate transmembrane transport • D-aspartate import across plasma membrane • regulation of membrane depolarization • membrane depolarization • multicellular organismal-level homeostasis • temperature homeostasis • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • negative regulation of systemic arterial blood pressure • blood circulation • negative regulation of blood pressure • positive regulation of amine transport • gamma-aminobutyric acid transport • regulation of amino acid transport • gamma-aminobutyric acid secretion • regulation of gamma-aminobutyric acid secretion • positive regulation of gamma-aminobutyric acid secretion • acid secretion • amine transport • positive regulation of amino acid transport • regulation of amine transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • vocalization behavior • regulation of glutamate secretion • positive regulation of secretion by cell • secretion by cell • regulation of secretion by cell • glutamate secretion • positive regulation of glutamate secretion • export from cell • response to nutrient levels • response to food • somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • dendritic shaft • neuron spine • synapse • dendritic spine
Gene Ontology	Cellular Component	• somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • dendritic shaft • neuron spine • synapse • dendritic spine • postsynapse • cell junction • axon • symmetric synapse • neuron to neuron synapse • axon terminus • presynapse • distal axon • terminal bouton • neuron projection terminus • cell surface • cell periphery • plasma membrane • membrane • membrane microdomain • membrane raft • cytoplasmic side of plasma membrane • cytoplasmic side of membrane • side of membrane • protein binding • binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide activity • hormone activity • neuropeptide hormone activity • G protein-coupled receptor binding • neuropeptide receptor binding • developmental process • multicellular organism development • multicellular organismal process • hepaticobiliary system development • gland development • animal organ development • anatomical structure development • liver development • system development • regulation of biological process • biological regulation • locomotion involved in locomotory behavior • regulation of behavior • behavior • locomotory behavior • regulation of locomotion • regulation of locomotion involved in locomotory behavior • regulation of multicellular organismal process • locomotion • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • response to stress • response to wounding • response to axon injury • cellular response to metal ion • cellular response to chemical stimulus • response to lithium ion • cellular response to lithium ion • response to metal ion • response to chemical • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • digestive system development • tube development • digestive tract development • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to endogenous stimulus • response to mineralocorticoid • positive regulation of cell communication • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of response to stimulus • regulation of cell communication • phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of signaling • response to light stimulus • system process • learning • learning or memory • nervous system process • visual learning • visual behavior • cognition • associative learning • response to radiation • response to abiotic stimulus • cellular response to endogenous stimulus • cellular response to growth factor stimulus • cellular response to nerve growth factor stimulus • response to nerve growth factor • response to growth factor • response to ketone • cellular response to ketone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • cellular response to dexamethasone stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to corticosteroid stimulus • cellular response to lipid • response to dexamethasone • response to osmotic stress • hyperosmotic response • response to alcohol • response to corticosterone • response to amine • response to nitrogen compound • response to amphetamine • negative regulation of metabolic process • negative regulation of biological process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • regulation of biological quality • blood circulation • regulation of anatomical structure size • response to antipsychotic drug • response to cocaine • response to alkaloid • response to estradiol • membrane-bounded organelle • intracellular anatomical structure • transport vesicle • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • cytoplasm • vesicle • extracellular region • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • response to prostaglandin • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to prostaglandin E • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • membrane protein complex • heterotrimeric G-protein complex • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SRW
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	SRW
Name	2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol
Synonyms
Identifier
Formula	C26 H31 F N4 O2
Molecular Weight	450.548
SMILES
PubChem	118610427
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	0
Total Bonds	68
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P20789
Sequence	>8FN0_nogp_Chain_R N S D L D V N T D I Y S K V L V T A I Y L A L F V V G T V G N S V T L F T L A S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V H H P W A F G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A I P M L F T M G L Q N R S A D G T H P G G L V C T P I V D T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I S D E Q W T T F L F D F Y H Y F Y M L T N A L F Y A S S A I N P I L Y N L V S A N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg	Gq; GRK2	3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPB (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg		3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg	Gq; GRK2	3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPC (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg		3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	SBI-553	chim(NtGi1-Go)/β1/γ2	2.89	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN0 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	SBI-553		2.89	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	SBI-553	-	3.02	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8ZYT	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.65	2025-04-09	doi.org/10.1038/s41422-025-01095-7
	8ZYY	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.83	2025-04-09	doi.org/10.1038/s41422-025-01095-7
	8ZYU	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.65	2025-04-16	doi.org/10.1038/s41422-025-01095-7
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.59	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FMZ (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.59	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi1-Go)/β1/γ2	2.88	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN1 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.88	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin-(8-13)	-	-	2.8	2012-10-17	doi.org/10.1038/nature11558
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	doi.org/10.1038/ncomms8895
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	doi.org/10.1038/ncomms8895
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	doi.org/10.1038/s41422-019-0256-2
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OS9 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OSA (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	doi.org/10.1038/s41586-020-1953-1
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.1	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0P (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.1	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.3	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0Q (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.3	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.2	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0R (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.2	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.5	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0S (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.5	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	doi.org/10.1038/srep38564
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	doi.org/10.1073/pnas.1317903111
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	doi.org/10.1126/sciadv.abe5504
	9M0D	A	Peptide	Neurotensin	NTS₁	Homo sapiens	-	-	Arrestin2	3.41	2025-04-09	doi.org/10.1038/s41422-025-01095-7

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