psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R8	R:R:P336	7.21	No	No	0	0	4
2	L:L:R8	R:R:Y339	12.35	No	Yes	0	0	2
3	L:L:P10	L:L:R9	4.32	Yes	No	1	0	0
4	L:L:R9	R:R:T230	5.17	No	No	0	0	4
5	L:L:R9	R:R:W334	11	No	Yes	1	0	4
6	L:L:P10	R:R:F326	5.78	Yes	Yes	1	0	4
7	L:L:P10	R:R:W334	20.27	Yes	Yes	1	0	4
8	L:L:P10	R:R:Y339	4.17	Yes	Yes	0	0	2
9	L:L:P10	R:R:Y342	9.74	Yes	Yes	1	0	4
10	L:L:I12	L:L:Y11	8.46	No	Yes	1	0	0
11	L:L:Y11	R:R:L54	3.52	Yes	Yes	1	0	5
12	L:L:Y11	R:R:H132	4.36	Yes	Yes	1	0	4
13	L:L:Y11	R:R:V223	6.31	Yes	No	0	0	4
14	L:L:Y11	R:R:Y339	4.96	Yes	Yes	0	0	2
15	L:L:I12	R:R:F127	20.09	No	Yes	1	0	4
16	L:L:I12	R:R:Y346	4.84	No	Yes	1	0	4
17	L:L:L13	R:R:Y145	8.21	Yes	Yes	0	0	4
18	L:L:L13	R:R:R323	6.07	Yes	Yes	0	0	6
19	L:L:L13	R:R:F326	6.09	Yes	Yes	0	0	4
20	L:L:L13	R:R:Y346	4.69	Yes	Yes	0	0	4
21	R:R:S51	R:R:S52	3.26	No	No	0	3	6
22	R:R:H218	R:R:S51	16.74	No	No	0	3	3
23	R:R:H132	R:R:L54	3.86	Yes	Yes	1	4	5
24	R:R:L54	R:R:R212	4.86	Yes	No	0	5	1
25	R:R:T58	R:R:V56	6.35	No	No	0	1	2
26	R:R:H343	R:R:V56	12.45	No	No	0	4	2
27	R:R:D340	R:R:N57	13.46	No	No	0	1	2
28	R:R:T58	R:R:Y344	13.73	No	No	0	1	1
29	R:R:D59	R:R:Y61	9.2	No	No	0	3	2
30	R:R:D59	R:R:S62	5.89	No	No	0	3	3
31	R:R:I60	R:R:Y61	4.84	No	No	0	2	2
32	R:R:K63	R:R:W129	27.85	No	No	0	5	5
33	R:R:V66	R:R:Y70	6.31	No	Yes	1	5	7
34	R:R:I128	R:R:V66	4.61	Yes	No	1	4	5
35	R:R:M347	R:R:V66	4.56	No	No	1	3	5
36	R:R:L71	R:R:T67	4.42	No	No	0	5	6
37	R:R:L124	R:R:T67	4.42	No	No	0	6	6
38	R:R:M120	R:R:Y70	10.78	Yes	Yes	1	8	7
39	R:R:E123	R:R:Y70	3.37	Yes	Yes	1	6	7
40	R:R:L124	R:R:Y70	4.69	No	Yes	1	6	7
41	R:R:I128	R:R:Y70	9.67	Yes	Yes	1	4	7
42	R:R:N350	R:R:Y70	4.65	Yes	Yes	1	6	7
43	R:R:Y354	R:R:Y70	9.93	Yes	Yes	1	7	7
44	R:R:L73	R:R:T358	4.42	No	No	0	7	7
45	R:R:F74	R:R:T78	15.56	No	No	1	7	6
46	R:R:F74	R:R:L116	6.09	No	No	1	7	7
47	R:R:F74	R:R:M120	8.71	No	Yes	1	7	8
48	R:R:G77	R:R:V76	3.68	No	No	0	8	6
49	R:R:T358	R:R:V76	4.76	No	No	0	7	6
50	R:R:A109	R:R:N81	4.69	No	No	0	9	9
51	R:R:D112	R:R:N81	12.12	Yes	No	0	9	9
52	R:R:N81	R:R:P361	9.77	No	No	0	9	9
53	R:R:F86	R:R:T82	3.89	No	No	0	4	4
54	R:R:L113	R:R:T82	5.9	No	No	0	7	4
55	R:R:F375	R:R:V83	7.87	Yes	No	0	7	6
56	R:R:T378	R:R:V83	3.17	No	No	0	5	6
57	R:R:A109	R:R:T84	3.36	No	No	0	9	9
58	R:R:P361	R:R:T84	3.5	No	No	0	9	9
59	R:R:F371	R:R:T84	5.19	Yes	No	0	8	9
60	R:R:A85	R:R:L110	3.15	No	No	0	8	6
61	R:R:F371	R:R:T87	3.89	Yes	No	0	8	7
62	R:R:I374	R:R:T87	7.6	No	No	0	6	7
63	R:R:E165	R:R:T100	14.11	Yes	No	4	8	7
64	R:R:M180	R:R:T100	7.53	Yes	No	4	7	7
65	R:R:T100	R:R:T185	3.14	No	No	0	7	7
66	R:R:E165	R:R:V101	5.7	Yes	No	0	8	8
67	R:R:R166	R:R:V101	6.54	No	No	0	9	8
68	R:R:T185	R:R:Y103	6.24	No	Yes	0	7	5
69	R:R:K186	R:R:Y103	13.14	No	Yes	2	3	5
70	R:R:I189	R:R:Y103	3.63	No	Yes	2	7	5
71	R:R:H104	R:R:S161	5.58	No	No	0	8	7
72	R:R:E165	R:R:H104	20.92	Yes	No	0	8	8
73	R:R:L105	R:R:L162	6.92	No	No	0	8	9
74	R:R:L105	R:R:Y364	11.72	No	Yes	0	8	9
75	R:R:N158	R:R:S107	10.43	Yes	No	2	8	9
76	R:R:I189	R:R:S107	7.74	No	No	2	7	9
77	R:R:S107	R:R:W193	4.94	No	Yes	2	9	9
78	R:R:L108	R:R:S111	4.5	Yes	No	2	9	8
79	R:R:D112	R:R:L108	5.43	Yes	Yes	2	9	9
80	R:R:L108	R:R:N158	5.49	Yes	Yes	2	9	8
81	R:R:L108	R:R:V159	4.47	Yes	No	2	9	8
82	R:R:L108	R:R:N360	6.87	Yes	No	2	9	9
83	R:R:L108	R:R:Y364	3.52	Yes	Yes	2	9	9
84	R:R:S111	R:R:T155	7.99	No	No	0	8	9
85	R:R:N158	R:R:S111	5.96	Yes	No	2	8	8
86	R:R:D112	R:R:S357	8.83	Yes	No	0	9	9
87	R:R:D112	R:R:N360	6.73	Yes	No	2	9	9
88	R:R:L113	R:R:L117	6.92	No	No	1	7	5
89	R:R:L114	R:R:W193	3.42	No	Yes	0	8	9
90	R:R:C151	R:R:T115	5.07	No	No	0	7	7
91	R:R:F353	R:R:T115	3.89	Yes	No	0	7	7
92	R:R:L116	R:R:M120	4.24	No	Yes	1	7	8
93	R:R:L116	R:R:S357	7.51	No	No	0	7	9
94	R:R:L118	R:R:L147	5.54	No	No	0	5	5
95	R:R:A119	R:R:R148	4.15	No	Yes	0	7	7
96	R:R:A119	R:R:Y354	4	No	Yes	0	7	7
97	R:R:M120	R:R:P121	3.35	Yes	No	0	8	9
98	R:R:F136	R:R:V122	10.49	No	No	0	7	6
99	R:R:V122	R:R:Y144	6.31	No	Yes	0	6	6
100	R:R:E123	R:R:F127	3.5	Yes	Yes	1	6	4
101	R:R:E123	R:R:I128	9.56	Yes	Yes	1	6	4
102	R:R:E123	R:R:Y144	6.73	Yes	Yes	1	6	6
103	R:R:E123	R:R:R148	8.14	Yes	Yes	1	6	7
104	R:R:E123	R:R:Y346	8.98	Yes	Yes	1	6	4
105	R:R:E123	R:R:N350	10.52	Yes	Yes	1	6	6
106	R:R:E123	R:R:Y354	5.61	Yes	Yes	1	6	7
107	R:R:I128	R:R:L124	5.71	Yes	No	1	4	6
108	R:R:W129	R:R:Y125	20.26	No	No	3	5	5
109	R:R:H131	R:R:Y125	7.62	No	No	3	3	5
110	R:R:F127	R:R:N126	3.62	Yes	No	1	4	5
111	R:R:N126	R:R:W134	18.08	No	Yes	1	5	8
112	R:R:F127	R:R:W134	10.02	Yes	Yes	1	4	8
113	R:R:F127	R:R:Y144	6.19	Yes	Yes	1	4	6
114	R:R:F127	R:R:Y145	6.19	Yes	Yes	1	4	4
115	R:R:F127	R:R:Y346	5.16	Yes	Yes	1	4	4
116	R:R:I128	R:R:M347	7.29	Yes	No	1	4	3
117	R:R:H131	R:R:W129	7.41	No	No	3	3	5
118	R:R:H132	R:R:P133	16.78	Yes	No	1	4	5
119	R:R:G220	R:R:H132	3.18	No	Yes	1	5	4
120	R:R:G220	R:R:P133	4.06	No	No	1	5	5
121	R:R:F136	R:R:W134	4.01	No	Yes	0	7	8
122	R:R:C141	R:R:W134	6.53	No	Yes	1	9	8
123	R:R:W134	R:R:Y144	8.68	Yes	Yes	1	8	6
124	R:R:C224	R:R:W134	5.22	No	Yes	1	9	8
125	R:R:D138	R:R:E209	18.19	No	No	0	3	5
126	R:R:C141	R:R:C224	7.28	No	No	1	9	9
127	R:R:G208	R:R:R142	7.51	No	No	0	4	7
128	R:R:Y144	R:R:Y145	9.93	Yes	Yes	1	6	4
129	R:R:R148	R:R:Y144	12.35	Yes	Yes	1	7	6
130	R:R:M203	R:R:Y145	9.58	No	Yes	1	5	4
131	R:R:M207	R:R:Y145	14.37	No	Yes	1	6	4
132	R:R:F146	R:R:L204	13.4	No	No	0	6	5
133	R:R:R148	R:R:Y319	4.12	Yes	No	1	7	6
134	R:R:F353	R:R:R148	3.21	Yes	Yes	0	7	7
135	R:R:D149	R:R:Y153	13.79	Yes	Yes	1	5	7
136	R:R:A200	R:R:D149	6.18	No	Yes	0	7	5
137	R:R:D149	R:R:M203	4.16	Yes	No	1	5	5
138	R:R:D149	R:R:N240	8.08	Yes	No	1	5	6
139	R:R:T152	R:R:W316	3.64	No	Yes	0	7	8
140	R:R:L199	R:R:Y153	14.07	No	Yes	0	6	7
141	R:R:N240	R:R:Y153	11.63	No	Yes	1	6	7
142	R:R:S244	R:R:Y153	8.9	No	Yes	0	6	7
143	R:R:A154	R:R:W193	7.78	No	Yes	0	7	9
144	R:R:A154	R:R:S196	3.42	No	No	0	7	8
145	R:R:T155	R:R:W316	4.85	No	Yes	0	9	8
146	R:R:A156	R:R:P248	3.74	No	Yes	0	8	9
147	R:R:I192	R:R:L157	8.56	No	No	0	7	6
148	R:R:N158	R:R:W193	3.39	Yes	Yes	2	8	9
149	R:R:I252	R:R:V159	4.61	No	No	2	8	8
150	R:R:F312	R:R:V159	3.93	Yes	No	2	9	8
151	R:R:L255	R:R:S163	4.5	No	No	0	7	9
152	R:R:N256	R:R:S163	4.47	Yes	No	0	9	9
153	R:R:E165	R:R:M180	9.47	Yes	Yes	4	8	7
154	R:R:I170	R:R:R166	5.01	No	No	0	9	9
155	R:R:C171	R:R:Y167	9.41	Yes	Yes	5	7	8
156	R:R:H172	R:R:Y167	9.8	Yes	Yes	5	6	8
157	R:R:I258	R:R:Y167	6.04	No	Yes	0	5	8
158	R:R:I259	R:R:Y167	3.63	No	Yes	0	9	8
159	R:R:H172	R:R:L168	3.86	Yes	No	0	6	4
160	R:R:L168	R:R:M180	4.24	No	Yes	0	4	7
161	R:R:C171	R:R:I170	3.27	Yes	No	0	7	9
162	R:R:C171	R:R:H172	4.42	Yes	Yes	5	7	6
163	R:R:C171	R:R:K262	6.47	Yes	No	0	7	5
164	R:R:H172	R:R:K175	13.1	Yes	No	0	6	4
165	R:R:K175	R:R:L179	4.23	No	No	0	4	4
166	R:R:R184	R:R:S181	5.27	No	No	0	5	8
167	R:R:R182	R:R:S183	6.59	No	No	0	3	4
168	R:R:K187	R:R:R184	3.71	No	No	0	4	5
169	R:R:I189	R:R:K186	7.27	No	No	2	7	3
170	R:R:P202	R:R:V201	3.53	No	No	0	7	5
171	R:R:P202	R:R:V236	3.53	No	No	0	7	6
172	R:R:M203	R:R:M207	5.78	No	No	1	5	6
173	R:R:F205	R:R:T206	5.19	No	No	0	4	5
174	R:R:I228	R:R:T206	6.08	No	No	0	5	5
175	R:R:M207	R:R:P226	10.06	No	Yes	0	6	5
176	R:R:G208	R:R:Q210	3.29	No	No	0	4	1
177	R:R:E209	R:R:L222	9.28	No	No	0	5	4
178	R:R:Q210	R:R:T225	7.09	No	No	0	1	4
179	R:R:Q210	R:R:T227	8.5	No	No	0	1	3
180	R:R:G216	R:R:N211	5.09	No	No	0	2	2
181	R:R:R212	R:R:T225	3.88	No	No	0	1	4
182	R:R:D215	R:R:S213	5.89	Yes	No	0	2	1
183	R:R:G221	R:R:S213	3.71	No	No	0	2	1
184	R:R:D215	R:R:G216	5.03	Yes	No	0	2	2
185	R:R:D215	R:R:H218	3.78	Yes	No	0	2	3
186	R:R:A219	R:R:H218	4.39	No	No	0	1	3
187	R:R:P226	R:R:T225	3.5	Yes	No	0	5	4
188	R:R:P226	R:R:V233	8.84	Yes	No	0	5	5
189	R:R:F326	R:R:P226	4.33	Yes	Yes	0	4	5
190	R:R:I228	R:R:T227	4.56	No	No	0	5	3
191	R:R:I228	R:R:T232	12.16	No	No	0	5	4
192	R:R:K234	R:R:Y328	13.14	No	No	0	4	5
193	R:R:C327	R:R:I237	6.55	No	No	0	3	6
194	R:R:F242	R:R:Q238	12.88	No	No	0	5	5
195	R:R:Q238	R:R:Y328	4.51	No	No	0	5	5
196	R:R:N240	R:R:R323	3.62	No	Yes	1	6	6
197	R:R:F242	R:R:T241	6.49	No	No	0	5	6
198	R:R:H320	R:R:T241	5.48	No	No	0	7	6
199	R:R:F242	R:R:I246	5.02	No	No	0	5	5
200	R:R:F245	R:R:I246	3.77	Yes	No	0	8	5
201	R:R:F245	R:R:M249	4.98	Yes	No	2	8	6
202	R:R:F245	R:R:F312	4.29	Yes	Yes	2	8	9
203	R:R:F245	R:R:L317	3.65	Yes	No	0	8	7
204	R:R:F245	R:R:H320	11.31	Yes	No	0	8	7
205	R:R:F247	R:R:P248	10.11	No	Yes	0	6	9
206	R:R:F247	R:R:V251	3.93	No	No	0	6	6
207	R:R:F312	R:R:M249	7.46	Yes	No	2	9	6
208	R:R:M249	R:R:V313	4.56	No	No	0	6	7
209	R:R:S253	R:R:V250	3.23	No	No	0	5	3
210	R:R:I252	R:R:N256	4.25	No	Yes	0	8	9
211	R:R:F312	R:R:I252	3.77	Yes	No	2	9	8
212	R:R:L305	R:R:N256	6.87	No	Yes	0	8	9
213	R:R:N256	R:R:V309	4.43	Yes	No	0	9	8
214	R:R:L298	R:R:V267	4.47	No	No	0	7	6
215	R:R:A270	R:R:R294	5.53	No	No	0	5	4
216	R:R:E291	R:R:P292	3.14	No	No	0	4	3
217	R:R:E291	R:R:R294	13.96	No	No	0	4	4
218	R:R:G293	R:R:P292	4.06	No	No	0	3	3
219	R:R:H300	R:R:Q296	13.6	No	No	0	8	5
220	R:R:R299	R:R:R303	10.66	No	Yes	0	5	7
221	R:R:H300	R:R:R303	4.51	No	Yes	0	8	7
222	R:R:R303	R:R:V304	3.92	Yes	No	0	7	8
223	R:R:L366	R:R:R303	3.64	No	Yes	0	6	7
224	R:R:V304	R:R:V367	4.81	No	No	0	8	7
225	R:R:F312	R:R:W316	19.04	Yes	Yes	0	9	8
226	R:R:C315	R:R:V355	3.42	No	No	0	9	5
227	R:R:C315	R:R:S356	5.16	No	No	0	9	9
228	R:R:F353	R:R:W316	9.02	Yes	Yes	0	7	8
229	R:R:S356	R:R:W316	6.18	No	Yes	0	9	8
230	R:R:L317	R:R:P318	3.28	No	No	0	7	9
231	R:R:P318	R:R:T349	3.5	No	No	0	9	6
232	R:R:L352	R:R:P318	3.28	No	No	0	7	9
233	R:R:R322	R:R:Y319	9.26	Yes	No	1	5	6
234	R:R:R323	R:R:Y319	13.38	Yes	No	1	6	6
235	R:R:R322	R:R:R323	3.2	Yes	Yes	1	5	6
236	R:R:R322	R:R:Y342	7.2	Yes	Yes	1	5	4
237	R:R:F345	R:R:R322	7.48	No	Yes	1	4	5
238	R:R:R322	R:R:Y346	15.43	Yes	Yes	1	5	4
239	R:R:R322	R:R:T349	12.94	Yes	No	1	5	6
240	R:R:N350	R:R:R322	3.62	Yes	Yes	1	6	5
241	R:R:F326	R:R:Y342	8.25	Yes	Yes	1	4	4
242	R:R:D331	R:R:S330	5.89	No	No	0	1	2
243	R:R:W334	R:R:Y342	5.79	Yes	Yes	1	4	4
244	R:R:P336	R:R:T335	5.25	No	No	0	4	4
245	R:R:D340	R:R:Y339	5.75	No	Yes	0	1	2
246	R:R:H343	R:R:Y339	18.51	No	Yes	0	4	2
247	R:R:H343	R:R:Y342	5.44	No	Yes	0	4	4
248	R:R:F345	R:R:T349	7.78	No	No	1	4	6
249	R:R:N350	R:R:Y346	18.61	Yes	Yes	1	6	4
250	R:R:N350	R:R:Y354	5.81	Yes	Yes	1	6	7
251	R:R:F353	R:R:Y354	8.25	Yes	Yes	0	7	7
252	R:R:N360	R:R:Y364	3.49	No	Yes	2	9	9
253	R:R:F371	R:R:Y364	4.13	Yes	Yes	2	8	9
254	R:R:F371	R:R:N365	4.83	Yes	No	2	8	7
255	R:R:F375	R:R:N365	18.12	Yes	No	2	7	7
256	R:R:F371	R:R:F375	5.36	Yes	Yes	2	8	7
257	R:R:I359	R:R:V355	3.07	No	No	0	6	5
258	R:R:K63	R:R:V130	3.04	No	No	0	5	5
259	R:R:F375	R:R:G80	3.01	Yes	No	0	7	9
260	R:R:K63	R:R:T67	3	No	No	0	5	6
261	R:R:L73	R:R:V69	2.98	No	No	0	7	4
262	R:R:L73	R:R:V355	2.98	No	No	0	7	5
263	R:R:L255	R:R:V164	2.98	No	No	0	7	7
264	R:R:L204	R:R:V201	2.98	No	No	0	5	5
265	R:R:L255	R:R:V251	2.98	No	No	0	7	6
266	R:R:L263	R:R:V302	2.98	No	No	0	8	7
267	R:R:L317	R:R:V321	2.98	No	No	0	7	5
268	R:R:N256	R:R:V308	2.96	Yes	No	0	9	8
269	R:R:L113	R:R:T78	2.95	No	No	1	7	6
270	R:R:L117	R:R:T78	2.95	No	No	1	5	6
271	R:R:N261	R:R:T264	2.92	No	No	0	4	5
272	R:R:F205	R:R:P202	2.89	No	No	0	4	7
273	R:R:K262	R:R:M266	2.88	No	No	0	5	6
274	R:R:E53	R:R:S213	2.87	No	No	0	2	1
275	L:L:L13	R:R:I237	2.85	Yes	No	0	0	6
276	R:R:I170	R:R:L263	2.85	No	No	0	9	8
277	R:R:I359	R:R:L363	2.85	No	No	0	6	8
278	R:R:L199	R:R:M243	2.83	No	No	0	6	5
279	R:R:G137	R:R:W134	2.81	No	Yes	0	8	8
280	R:R:L114	R:R:L118	2.77	No	No	0	8	5
281	R:R:E53	R:R:L54	2.65	No	Yes	0	2	5
282	R:R:F371	R:R:S368	2.64	Yes	No	0	8	8
283	R:R:R299	R:R:V302	2.62	No	No	0	5	7
284	R:R:F345	R:R:M325	2.49	No	No	0	4	4
285	R:R:F375	R:R:L376	2.44	Yes	No	0	7	4
286	R:R:L376	R:R:R372	2.43	No	No	0	4	9
287	R:R:I329	R:R:W334	2.35	No	Yes	0	3	4
288	R:R:L324	R:R:Y328	2.34	No	No	0	6	5
289	R:R:H102	R:R:Y103	2.18	No	Yes	0	8	5
290	R:R:R299	R:R:R306	2.13	No	No	0	5	5
291	R:R:A109	R:R:G106	1.95	No	No	0	9	6
292	R:R:A160	R:R:P248	1.87	No	Yes	0	8	9
293	R:R:G80	R:R:V79	1.84	No	No	0	9	5
294	R:R:A150	R:R:A200	1.79	No	No	0	6	7
295	R:R:A197	R:R:S196	1.71	No	No	0	4	8
296	R:R:D138	R:R:G137	1.68	No	No	0	3	8
297	R:R:L157	R:R:P248	1.64	No	Yes	0	6	9
298	R:R:G293	R:R:Q296	1.64	No	No	0	3	5
299	R:R:S253	R:R:V254	1.62	No	No	0	5	5
300	R:R:S253	R:R:V309	1.62	No	No	0	5	8
301	R:R:A311	R:R:I359	1.62	No	No	0	7	6
302	R:R:A176	R:R:M180	1.61	No	Yes	0	6	7
303	R:R:T257	R:R:V254	1.59	No	No	0	3	5
304	R:R:T264	R:R:V302	1.59	No	No	0	5	7
305	R:R:A260	R:R:L305	1.58	No	No	0	6	8
306	R:R:A135	R:R:N126	1.56	No	No	0	3	5
307	R:R:H172	R:R:P173	1.53	Yes	No	0	6	8
308	R:R:K186	R:R:S190	1.53	No	No	0	3	4
309	R:R:M243	R:R:V239	1.52	No	No	0	5	5
310	R:R:M266	R:R:V265	1.52	No	No	0	6	4
311	R:R:A214	R:R:E53	1.51	No	No	0	1	2
312	R:R:F136	R:R:G140	1.51	No	No	0	7	6
313	R:R:F146	R:R:G143	1.51	No	No	0	6	5
314	R:R:K175	R:R:T178	1.5	No	No	0	4	4
315	R:R:L65	R:R:V69	1.49	No	No	0	5	4
316	R:R:L198	R:R:V201	1.49	No	No	0	4	5
317	R:R:L352	R:R:V314	1.49	No	No	0	7	6
318	R:R:L352	R:R:V348	1.49	No	No	0	7	6
319	R:R:N370	R:R:S368	1.49	No	No	0	7	8
320	R:R:L338	R:R:T335	1.47	No	No	0	1	4
321	R:R:E332	R:R:S330	1.44	No	No	0	1	2
322	R:R:L298	R:R:M266	1.41	No	No	0	7	6
323	R:R:L110	R:R:L114	1.38	No	No	0	6	8
324	R:R:A169	R:R:R166	1.38	No	No	0	8	9
325	R:R:H229	R:R:T230	1.37	No	No	0	4	4
326	R:R:I329	R:R:Q333	1.37	No	No	0	3	1
327	R:R:A351	R:R:Y70	1.33	No	Yes	0	5	7
328	R:R:F188	R:R:S161	1.32	No	No	0	6	7
329	R:R:D215	R:R:Q217	1.31	Yes	No	0	2	1
330	R:R:R268	R:R:V267	1.31	No	No	0	4	6
331	R:R:S62	R:R:Y344	1.27	No	No	0	3	1
332	R:R:D55	R:R:H132	1.26	No	Yes	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P10	8.856	5	1	0
2	L:L:Y11	5.522	5	1	0
3	L:L:L13	5.582	5	0	0
4	R:R:L54	3.7225	4	1	5
5	R:R:Y70	6.34125	8	1	7
6	R:R:Y103	6.2975	4	2	5
7	R:R:L108	5.04667	6	2	9
8	R:R:D112	8.2775	4	2	9
9	R:R:M120	6.77	4	1	8
10	R:R:E123	7.05125	8	1	6
11	R:R:F127	7.82429	7	1	4
12	R:R:I128	7.368	5	1	4
13	R:R:H132	5.888	5	1	4
14	R:R:W134	7.90714	7	1	8
15	R:R:Y144	8.365	6	1	6
16	R:R:Y145	9.656	5	1	4
17	R:R:R148	6.394	5	1	7
18	R:R:D149	8.0525	4	1	5
19	R:R:Y153	12.0975	4	1	7
20	R:R:N158	6.3175	4	2	8
21	R:R:E165	12.55	4	4	8
22	R:R:Y167	7.22	4	5	8
23	R:R:C171	5.8925	4	5	7
24	R:R:H172	6.542	5	5	6
25	R:R:M180	5.7125	4	4	7
26	R:R:W193	4.8825	4	2	9
27	R:R:D215	4.0025	4	0	2
28	R:R:P226	6.6825	4	0	5
29	R:R:F245	5.6	5	2	8
30	R:R:P248	4.34	4	0	9
31	R:R:N256	4.596	5	0	9
32	R:R:R303	5.6825	4	0	7
33	R:R:F312	7.698	5	2	9
34	R:R:W316	8.546	5	0	8
35	R:R:R322	8.44714	7	1	5
36	R:R:R323	6.5675	4	1	6
37	R:R:F326	6.1125	4	1	4
38	R:R:W334	9.8525	4	1	4
39	R:R:Y339	9.148	5	0	2
40	R:R:Y342	7.284	5	1	4
41	R:R:Y346	9.61833	6	1	4
42	R:R:N350	8.642	5	1	6
43	R:R:F353	6.0925	4	0	7
44	R:R:Y354	6.72	5	1	7
45	R:R:Y364	5.715	4	2	9
46	R:R:F371	4.34	6	2	8
47	R:R:F375	7.36	5	2	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R8	R:R:Y339	16.8273	12.35	No	Yes	0	0	2
2	R:R:H343	R:R:Y342	14.3088	5.44	No	Yes	0	4	4
3	L:L:I12	L:L:Y11	63.1421	8.46	No	Yes	1	0	0
4	L:L:Y11	R:R:Y339	17.1421	4.96	Yes	Yes	0	0	2
5	L:L:Y11	R:R:L54	34.2799	3.52	Yes	Yes	1	0	5
6	L:L:I12	R:R:F127	30.7085	20.09	No	Yes	1	0	4
7	L:L:I12	R:R:Y346	34.416	4.84	No	Yes	1	0	4
8	R:R:R322	R:R:Y342	32.3996	7.2	Yes	Yes	1	5	4
9	R:R:E53	R:R:L54	30.0662	2.65	No	Yes	0	2	5
10	R:R:E53	R:R:S213	25.0973	2.87	No	No	0	2	1
11	R:R:D215	R:R:S213	20.1115	5.89	Yes	No	0	2	1
12	R:R:D215	R:R:H218	10.0887	3.78	Yes	No	0	2	3
13	R:R:N350	R:R:R322	18.1312	3.62	Yes	Yes	1	6	5
14	R:R:N350	R:R:Y70	12.5433	4.65	Yes	Yes	1	6	7
15	R:R:N350	R:R:Y346	15.1915	18.61	Yes	Yes	1	6	4
16	R:R:E123	R:R:F127	26.2055	3.5	Yes	Yes	1	6	4
17	R:R:E123	R:R:Y70	14.0131	3.37	Yes	Yes	1	6	7
18	R:R:E123	R:R:Y346	26.2204	8.98	Yes	Yes	1	6	4
19	R:R:M120	R:R:Y70	23.8211	10.78	Yes	Yes	1	8	7
20	R:R:N350	R:R:Y354	20.6007	5.81	Yes	Yes	1	6	7
21	R:R:E123	R:R:Y354	19.6754	5.61	Yes	Yes	1	6	7
22	R:R:R322	R:R:Y319	10.931	9.26	Yes	No	1	5	6
23	R:R:R148	R:R:Y319	15.5	4.12	Yes	No	1	7	6
24	R:R:F353	R:R:R148	57.2459	3.21	Yes	Yes	0	7	7
25	R:R:F353	R:R:W316	100	9.02	Yes	Yes	0	7	8
26	R:R:S356	R:R:W316	13.2453	6.18	No	Yes	0	9	8
27	R:R:C315	R:R:S356	12.1647	5.16	No	No	0	9	9
28	R:R:C315	R:R:V355	11.0799	3.42	No	No	0	9	5
29	R:R:E123	R:R:R148	19.7137	8.14	Yes	Yes	1	6	7
30	R:R:R148	R:R:Y144	22.9149	12.35	Yes	Yes	1	7	6
31	R:R:F353	R:R:Y354	44.075	8.25	Yes	Yes	0	7	7
32	R:R:L116	R:R:M120	18.7246	4.24	No	Yes	1	7	8
33	R:R:L116	R:R:S357	20.1136	7.51	No	No	0	7	9
34	R:R:D112	R:R:S357	19.8264	8.83	Yes	No	0	9	9
35	R:R:T155	R:R:W316	61.2448	4.85	No	Yes	0	9	8
36	R:R:S111	R:R:T155	60.5598	7.99	No	No	0	8	9
37	R:R:L108	R:R:S111	12.8879	4.5	Yes	No	2	9	8
38	R:R:L108	R:R:Y364	33.3036	3.52	Yes	Yes	2	9	9
39	R:R:F371	R:R:Y364	31.67	4.13	Yes	Yes	2	8	9
40	R:R:F371	R:R:F375	16.8613	5.36	Yes	Yes	2	8	7
41	R:R:F312	R:R:W316	32.7207	19.04	Yes	Yes	0	9	8
42	R:R:F312	R:R:V159	18.7948	3.93	Yes	No	2	9	8
43	R:R:L108	R:R:V159	22.1917	4.47	Yes	No	2	9	8
44	R:R:D112	R:R:L108	11.0395	5.43	Yes	Yes	2	9	9
45	R:R:N158	R:R:S111	47.1295	5.96	Yes	No	2	8	8
46	R:R:N158	R:R:S107	49.0566	10.43	Yes	No	2	8	9
47	R:R:I189	R:R:S107	49.1417	7.74	No	No	2	7	9
48	R:R:I189	R:R:Y103	46.2425	3.63	No	Yes	2	7	5
49	R:R:T185	R:R:Y103	44.6174	6.24	No	Yes	0	7	5
50	R:R:T100	R:R:T185	43.6879	3.14	No	No	0	7	7
51	R:R:E165	R:R:T100	24.8867	14.11	Yes	No	4	8	7
52	R:R:M180	R:R:T100	17.8674	7.53	Yes	No	4	7	7
53	R:R:E165	R:R:V101	21.2473	5.7	Yes	No	0	8	8
54	R:R:R166	R:R:V101	20.2731	6.54	No	No	0	9	8
55	R:R:P226	R:R:T225	15.3319	3.5	Yes	No	0	5	4
56	R:R:Q210	R:R:T225	14.547	7.09	No	No	0	1	4
57	R:R:M207	R:R:P226	10.9714	10.06	No	Yes	0	6	5
58	R:R:Q210	R:R:T227	11.7138	8.5	No	No	0	1	3
59	R:R:I228	R:R:T227	10.7609	4.56	No	No	0	5	3
60	R:R:F312	R:R:I252	17.9504	3.77	Yes	No	2	9	8
61	R:R:I252	R:R:N256	21.0133	4.25	No	Yes	0	8	9
62	R:R:N256	R:R:S163	11.2501	4.47	Yes	No	0	9	9
63	R:R:L255	R:R:S163	10.144	4.5	No	No	0	7	9
64	R:R:I170	R:R:R166	18.3566	5.01	No	No	0	9	9
65	R:R:L168	R:R:M180	16.1083	4.24	No	Yes	0	4	7
66	R:R:H172	R:R:L168	15.249	3.86	Yes	No	0	6	4
67	R:R:I170	R:R:L263	17.8334	2.85	No	No	0	9	8
68	R:R:L263	R:R:V302	16.8953	2.98	No	No	0	8	7
69	R:R:R299	R:R:V302	13.8557	2.62	No	No	0	5	7
70	R:R:R299	R:R:R303	11.7372	10.66	No	Yes	0	5	7
71	L:L:R8	R:R:P336	12.6263	7.21	No	No	0	0	4
72	R:R:Y144	R:R:Y145	12.1179	9.93	Yes	Yes	1	6	4
73	R:R:M207	R:R:Y145	10.6183	14.37	No	Yes	1	6	4
74	R:R:L108	R:R:N158	11.5798	5.49	Yes	Yes	2	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R8	R:R:P336	7.21	0	No	No	0	4	0	1
L:L:R8	R:R:Y339	12.35	0	No	Yes	0	2	0	1
L:L:R9	R:R:T230	5.17	1	No	No	0	4	0	1
L:L:R9	R:R:W334	11	1	No	Yes	0	4	0	1
L:L:P10	R:R:F326	5.78	1	Yes	Yes	0	4	0	1
L:L:P10	R:R:W334	20.27	1	Yes	Yes	0	4	0	1
L:L:P10	R:R:Y339	4.17	1	Yes	Yes	0	2	0	1
L:L:P10	R:R:Y342	9.74	1	Yes	Yes	0	4	0	1
L:L:Y11	R:R:L54	3.52	1	Yes	Yes	0	5	0	1
L:L:Y11	R:R:H132	4.36	1	Yes	Yes	0	4	0	1
L:L:Y11	R:R:V223	6.31	1	Yes	No	0	4	0	1
L:L:Y11	R:R:Y339	4.96	1	Yes	Yes	0	2	0	1
L:L:I12	R:R:F127	20.09	1	No	Yes	0	4	0	1
L:L:I12	R:R:Y346	4.84	1	No	Yes	0	4	0	1
L:L:L13	R:R:Y145	8.21	0	Yes	Yes	0	4	0	1
L:L:L13	R:R:R323	6.07	0	Yes	Yes	0	6	0	1
L:L:L13	R:R:F326	6.09	0	Yes	Yes	0	4	0	1
L:L:L13	R:R:Y346	4.69	0	Yes	Yes	0	4	0	1
R:R:H132	R:R:L54	3.86	1	Yes	Yes	4	5	1	1
R:R:L54	R:R:R212	4.86	1	Yes	No	5	1	1	2
R:R:E123	R:R:F127	3.5	1	Yes	Yes	6	4	2	1
R:R:E123	R:R:Y144	6.73	1	Yes	Yes	6	6	2	2
R:R:E123	R:R:Y346	8.98	1	Yes	Yes	6	4	2	1
R:R:E123	R:R:N350	10.52	1	Yes	Yes	6	6	2	2
R:R:F127	R:R:N126	3.62	1	Yes	No	4	5	1	2
R:R:N126	R:R:W134	18.08	1	No	Yes	5	8	2	2
R:R:F127	R:R:W134	10.02	1	Yes	Yes	4	8	1	2
R:R:F127	R:R:Y144	6.19	1	Yes	Yes	4	6	1	2
R:R:F127	R:R:Y145	6.19	1	Yes	Yes	4	4	1	1
R:R:F127	R:R:Y346	5.16	1	Yes	Yes	4	4	1	1
R:R:H132	R:R:P133	16.78	1	Yes	No	4	5	1	2
R:R:G220	R:R:H132	3.18	1	No	Yes	5	4	2	1
R:R:G220	R:R:P133	4.06	1	No	No	5	5	2	2
R:R:W134	R:R:Y144	8.68	1	Yes	Yes	8	6	2	2
R:R:Y144	R:R:Y145	9.93	1	Yes	Yes	6	4	2	1
R:R:M203	R:R:Y145	9.58	1	No	Yes	5	4	2	1
R:R:M207	R:R:Y145	14.37	1	No	Yes	6	4	2	1
R:R:M203	R:R:M207	5.78	1	No	No	5	6	2	2
R:R:M207	R:R:P226	10.06	1	No	Yes	6	5	2	2
R:R:F326	R:R:P226	4.33	1	Yes	Yes	4	5	1	2
R:R:C327	R:R:I237	6.55	0	No	No	3	6	2	1
R:R:N240	R:R:R323	3.62	1	No	Yes	6	6	2	1
R:R:R322	R:R:Y319	9.26	1	Yes	No	5	6	2	2
R:R:R323	R:R:Y319	13.38	1	Yes	No	6	6	1	2
R:R:R322	R:R:R323	3.2	1	Yes	Yes	5	6	2	1
R:R:R322	R:R:Y342	7.2	1	Yes	Yes	5	4	2	1
R:R:R322	R:R:Y346	15.43	1	Yes	Yes	5	4	2	1
R:R:N350	R:R:R322	3.62	1	Yes	Yes	6	5	2	2
R:R:F326	R:R:Y342	8.25	1	Yes	Yes	4	4	1	1
R:R:W334	R:R:Y342	5.79	1	Yes	Yes	4	4	1	1
R:R:P336	R:R:T335	5.25	0	No	No	4	4	1	2
R:R:D340	R:R:Y339	5.75	0	No	Yes	1	2	2	1
R:R:H343	R:R:Y339	18.51	0	No	Yes	4	2	2	1
R:R:H343	R:R:Y342	5.44	0	No	Yes	4	4	2	1
R:R:N350	R:R:Y346	18.61	1	Yes	Yes	6	4	2	1
L:L:L13	R:R:I237	2.85	0	Yes	No	0	6	0	1
R:R:E53	R:R:L54	2.65	0	No	Yes	2	5	2	1
R:R:I329	R:R:W334	2.35	0	No	Yes	3	4	2	1
R:R:H229	R:R:T230	1.37	0	No	No	4	4	2	1
R:R:D55	R:R:H132	1.26	0	No	Yes	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JPB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.14
Number of Linked Nodes	278
Number of Links	332
Number of Hubs	47
Number of Links mediated by Hubs	174
Number of Communities	5
Number of Nodes involved in Communities	72
Number of Links involved in Communities	108

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	87060
Length Of Smallest Path	3
Average Path Length	14.7327
Length of Longest Path	41
Minimum Path Strength	1.465
Average Path Strength	6.6306
Maximum Path Strength	24.055
Minimum Path Correlation	0.7
Average Path Correlation	0.925859
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	46.8838
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.8589
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• catalytic activity, acting on a protein • beta-adrenergic receptor kinase activity • kinase activity • protein kinase activity • transferase activity • catalytic activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • Edg-2 lysophosphatidic acid receptor binding • protein binding • binding • signaling receptor binding • endothelial differentiation G protein-coupled receptor binding • G protein-coupled receptor binding • adenyl ribonucleotide binding • nucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • adenyl nucleotide binding • ATP binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • adrenergic receptor binding • alpha-2A adrenergic receptor binding • protein serine/threonine kinase activity • G protein-coupled receptor kinase activity • protein localization • regulation of localization • regulation of biological process • cellular localization • regulation of cellular process • regulation of protein localization • protein localization to cilium • biological regulation • positive regulation of biological process • positive regulation of protein localization to cilium • regulation of protein localization to cilium • localization • regulation of cellular localization • cellular macromolecule localization • macromolecule localization
Gene Ontology	Biological Process	• protein localization • regulation of localization • regulation of biological process • cellular localization • regulation of cellular process • regulation of protein localization • protein localization to cilium • biological regulation • positive regulation of biological process • positive regulation of protein localization to cilium • regulation of protein localization to cilium • localization • regulation of cellular localization • cellular macromolecule localization • macromolecule localization • protein localization to organelle • positive regulation of protein localization • cellular process • positive regulation of cellular process • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • regulation of system process • negative regulation of biological process • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • negative regulation of muscle contraction • regulation of striated muscle contraction • regulation of muscle contraction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • negative regulation of striated muscle contraction • heart process • regulation of heart contraction • circulatory system process • regulation of blood circulation • regulation of biological quality • heart contraction • regulation of the force of heart contraction • blood circulation • cellular response to stimulus • regulation of signaling • response to stimulus • signaling • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • signal transduction • biological process involved in interspecies interaction between organisms • symbiont entry into host cell • viral process • symbiont entry into host • viral life cycle • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral genome replication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of smoothened signaling pathway • regulation of smoothened signaling pathway • cell surface receptor signaling pathway • smoothened signaling pathway • positive regulation of signaling • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • G protein-coupled receptor signaling pathway • establishment of protein localization • nitrogen compound transport • transport • intracellular transport • establishment of localization • protein transport • establishment of localization in cell • intracellular protein transport • negative regulation of blood circulation • negative regulation of heart contraction • negative regulation of the force of heart contraction by chemical signal • regulation of the force of heart contraction by chemical signal • protein phosphorylation • phosphorylation • primary metabolic process • macromolecule modification • phosphate-containing compound metabolic process • metabolic process • protein metabolic process • macromolecule metabolic process • protein modification process • phosphorus metabolic process • cardiac muscle contraction • peptidyl-serine modification • peptidyl-serine phosphorylation • peptidyl-amino acid modification • tachykinin receptor signaling pathway • negative regulation of relaxation of smooth muscle • relaxation of smooth muscle • negative regulation of relaxation of muscle • relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • import into cell • receptor internalization • vesicle-mediated transport • G protein-coupled receptor internalization • receptor-mediated endocytosis • endocytosis • cellular anatomical structure • membrane • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • presynapse • synapse • cell junction • membrane-bounded organelle • mitochondrial membrane • mitochondrion • cytoplasmic side of membrane
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • presynapse • synapse • cell junction • membrane-bounded organelle • mitochondrial membrane • mitochondrion • cytoplasmic side of membrane • organelle outer membrane • cytoplasmic side of mitochondrial outer membrane • intracellular membrane-bounded organelle • side of membrane • intracellular organelle • organelle envelope • bounding membrane of organelle • organelle • mitochondrial envelope • mitochondrial outer membrane • outer membrane • organelle membrane • postsynapse • cell projection • pyrophosphatase activity • enzyme regulator activity • GTPase activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • hydrolase activity • GTPase regulator activity • enzyme activator activity • ribonucleoside triphosphate phosphatase activity • GTPase activator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • molecular function regulator activity • hydrolase activity, acting on acid anhydrides • catalytic activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of protein modification process • regulation of catalytic activity • regulation of protein phosphorylation • negative regulation of biological process • negative regulation of phosphate metabolic process • negative regulation of catalytic activity • regulation of transferase activity • regulation of primary metabolic process • negative regulation of kinase activity • negative regulation of transferase activity • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • negative regulation of cellular process • protein metabolic process • phosphorus metabolic process • protein modification process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • negative regulation of molecular function • primary metabolic process • negative regulation of protein kinase activity • regulation of protein kinase activity • regulation of macromolecule metabolic process • regulation of molecular function • regulation of kinase activity • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • metabolic process • macromolecule metabolic process • negative regulation of phosphorylation • regulation of metabolic process • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • nuclear membrane • nucleus • endomembrane system • nuclear envelope • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • cytosolic region • postsynaptic cytosol • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled neurotensin receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • identical protein binding • adult locomotory behavior • behavior • adult behavior • locomotory behavior • system process • learning • learning or memory • nervous system process • cognition • regulation of calcium ion transport • regulation of localization • intracellular calcium ion homeostasis • negative regulation of transport • calcium ion transport • localization • negative regulation of cation transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • negative regulation of calcium ion transmembrane transport • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • positive regulation of biological process • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • negative regulation of transmembrane transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of sequestering of calcium ion • negative regulation of monoatomic ion transmembrane transport • negative regulation of release of sequestered calcium ion into cytosol • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • monoatomic ion transport • intracellular chemical homeostasis • regulation of metal ion transport • regulation of sequestering of calcium ion • positive regulation of cellular process • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • negative regulation of calcium ion transport • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • regulation of postsynaptic membrane potential • regulation of system process • chemical synaptic transmission, postsynaptic • positive regulation of inhibitory postsynaptic potential • positive regulation of nervous system process • modulation of inhibitory postsynaptic potential • trans-synaptic signaling • regulation of nervous system process • chemical synaptic transmission • anterograde trans-synaptic signaling • inhibitory postsynaptic potential • positive regulation of multicellular organismal process • regulation of membrane potential • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of biosynthetic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of programmed cell death • positive regulation of apoptotic process • organic acid transmembrane transport • import into cell • nitrogen compound transport • organic anion transport • carboxylic acid transport • carboxylic acid transmembrane transport • aspartate transmembrane transport • import across plasma membrane • amino acid transmembrane transport • C4-dicarboxylate transport • D-amino acid transport • organic acid transport • amino acid transport • D-aspartate transmembrane transport • D-aspartate import across plasma membrane • dicarboxylic acid transport • amino acid import across plasma membrane • positive regulation of arachidonate secretion • regulation of lipid transport • regulation of arachidonate secretion • arachidonate secretion • monocarboxylic acid transport • positive regulation of secretion • fatty acid transport • icosanoid transport • regulation of icosanoid secretion • icosanoid secretion • long-chain fatty acid transport • positive regulation of icosanoid secretion • secretion • arachidonate transport • lipid localization • lipid transport • positive regulation of lipid localization • regulation of fatty acid transport • regulation of secretion • positive regulation of organic acid transport • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • regulation of membrane depolarization • membrane depolarization • polyol metabolic process • alcohol catabolic process • catabolic process • polyol catabolic process • organophosphate catabolic process • alcohol metabolic process • inositol phosphate metabolic process • organophosphate metabolic process • inositol phosphate catabolic process • small molecule metabolic process • small molecule catabolic process • detection of stimulus involved in sensory perception of pain • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • sensory perception • detection of temperature stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • L-amino acid transport • L-glutamate import • L-glutamate import across plasma membrane • acidic amino acid transport • L-alpha-amino acid transmembrane transport • L-glutamate transmembrane transport • multicellular organismal-level homeostasis • temperature homeostasis • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • negative regulation of systemic arterial blood pressure • blood circulation • negative regulation of blood pressure • positive regulation of amine transport • gamma-aminobutyric acid transport • regulation of amino acid transport • gamma-aminobutyric acid secretion • regulation of gamma-aminobutyric acid secretion • positive regulation of gamma-aminobutyric acid secretion • acid secretion • amine transport • positive regulation of amino acid transport • regulation of amine transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • regulation of glutamate secretion • positive regulation of secretion by cell • secretion by cell • regulation of secretion by cell • glutamate secretion • positive regulation of glutamate secretion • export from cell • regulation of inositol phosphate biosynthetic process • positive regulation of phosphate metabolic process • regulation of small molecule metabolic process • polyol biosynthetic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • symmetric synapse • neuron to neuron synapse • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • axon terminus • distal axon • terminal bouton • neuron projection terminus • cell surface • membrane microdomain • membrane raft • dendrite • dendritic tree • dendritic shaft • neuron spine • dendritic spine • endoplasmic reticulum
SCOP2	Domain Identifier	• Protein kinase-like (PK-like) • Regulator of G-protein signaling, RGS • PH domain-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Protein kinase-like (PK-like) • Regulator of G-protein signaling, RGS • PH domain-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30989
Sequence	>8JPB_nogp_Chain_R S S E L D V N T D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V H H P W A F G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A V P M L F T M G E Q N R S A D G Q H A G G L V C T P T I H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I S D E Q W T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F R H I F L A T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	PubChem 118610427	-	3.02	2023-08-09	10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPC (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg		3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPB (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg		3.07	2023-08-09	10.1038/s41586-023-06395-9
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi1-Go)/β1/γ2	2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8FN1 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	PubChem 118610427	chim(NtGi1-Go)/β1/γ2	2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	PubChem 118610427		2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.59	2023-03-29	10.1021/acs.biochem.3c00029
	8FMZ (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.59	2023-03-29	10.1021/acs.biochem.3c00029
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	10.1038/s41594-022-00859-8
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	10.1126/sciadv.abe5504
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	10.1126/sciadv.abe5504
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.5	2021-01-06	10.1038/s41594-020-00554-6
	7L0S (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.5	2021-01-06	10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0R (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.1	2021-01-06	10.1038/s41594-020-00554-6
	7L0P (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.1	2021-01-06	10.1038/s41594-020-00554-6
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	10.1038/s41586-020-1953-1
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	10.1038/s41422-019-0256-2
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OSA (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	10.1038/s41586-019-1337-6
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OS9 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	10.1038/s41586-019-1337-6
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	10.1038/srep38564
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	10.1038/ncomms8895
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	10.1038/ncomms8895
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	10.1073/pnas.1317903111
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	10.1073/pnas.1317903111
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin-(8-13)	-	-	2.8	2012-10-17	10.1038/nature11558

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