psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R1	R:R:F344	6.41	No	Yes	0	0	3
2	L:L:P3	L:L:R2	2.88	Yes	Yes	1	0	0
3	L:L:R2	R:R:D336	4.76	Yes	No	0	0	2
4	L:L:R2	R:R:W339	5	Yes	Yes	1	0	7
5	L:L:P3	R:R:W339	13.51	Yes	Yes	1	0	7
6	L:L:P3	R:R:F344	5.78	Yes	Yes	1	0	3
7	L:L:P3	R:R:Y347	8.34	Yes	Yes	1	0	4
8	L:L:P3	R:R:H348	3.05	Yes	Yes	1	0	4
9	L:L:I5	L:L:Y4	6.04	No	Yes	0	0	0
10	L:L:Y4	R:R:L55	9.38	Yes	No	0	0	2
11	L:L:Y4	R:R:H133	8.71	Yes	Yes	0	0	5
12	L:L:Y4	R:R:V224	13.88	Yes	No	0	0	5
13	L:L:I5	R:R:F128	8.79	No	Yes	1	0	6
14	L:L:I5	R:R:Y351	4.84	No	Yes	1	0	4
15	L:L:L6	R:R:Y146	5.86	Yes	Yes	0	0	5
16	L:L:L6	R:R:R328	6.07	Yes	Yes	0	0	6
17	L:L:L6	R:R:F331	6.09	Yes	No	0	0	3
18	L:L:L6	R:R:Y351	3.52	Yes	Yes	0	0	4
19	R:R:H219	R:R:N52	7.65	Yes	No	0	3	3
20	R:R:D54	R:R:L55	4.07	No	No	0	4	2
21	R:R:D56	R:R:H133	10.08	No	Yes	0	2	5
22	R:R:T59	R:R:V57	6.35	No	Yes	0	2	2
23	R:R:H132	R:R:V57	4.15	No	Yes	0	5	2
24	R:R:F344	R:R:V57	5.24	Yes	Yes	1	3	2
25	R:R:D345	R:R:V57	2.92	No	Yes	0	3	2
26	R:R:H348	R:R:V57	5.54	Yes	Yes	1	4	2
27	R:R:K64	R:R:T59	6.01	No	No	0	5	2
28	R:R:T59	R:R:Y349	7.49	No	No	0	2	1
29	R:R:D60	R:R:Y62	8.05	No	No	0	6	3
30	R:R:I61	R:R:W130	3.52	No	No	0	3	7
31	R:R:S63	R:R:Y349	8.9	No	No	0	2	1
32	R:R:I129	R:R:K64	7.27	No	No	0	5	5
33	R:R:K64	R:R:W130	13.92	No	No	0	5	7
34	R:R:T68	R:R:V65	3.17	No	No	0	6	5
35	R:R:V67	R:R:Y71	3.79	No	Yes	0	5	7
36	R:R:M352	R:R:V67	9.13	No	No	0	4	5
37	R:R:I129	R:R:T68	3.04	No	No	0	5	6
38	R:R:T68	R:R:W130	13.34	No	No	0	6	7
39	R:R:M121	R:R:Y71	7.18	Yes	Yes	1	7	7
40	R:R:N355	R:R:Y71	4.65	Yes	Yes	1	6	7
41	R:R:A356	R:R:Y71	5.34	No	Yes	0	5	7
42	R:R:Y359	R:R:Y71	6.95	Yes	Yes	1	7	7
43	R:R:L74	R:R:V360	7.45	No	No	0	7	6
44	R:R:F75	R:R:T79	3.89	Yes	No	0	6	6
45	R:R:F75	R:R:L117	4.87	Yes	No	0	6	6
46	R:R:F75	R:R:M121	9.95	Yes	Yes	0	6	7
47	R:R:D113	R:R:N82	4.04	Yes	No	0	9	9
48	R:R:L114	R:R:N82	6.87	No	No	0	8	9
49	R:R:N82	R:R:P366	13.03	No	No	0	9	9
50	R:R:F380	R:R:V84	5.24	Yes	No	0	6	6
51	R:R:T383	R:R:V84	3.17	No	No	0	4	6
52	R:R:L89	R:R:T85	2.95	No	No	0	7	9
53	R:R:F380	R:R:T85	3.89	Yes	No	0	6	9
54	R:R:L111	R:R:L86	4.15	No	No	0	6	7
55	R:R:F87	R:R:R91	11.76	No	No	0	3	6
56	R:R:F380	R:R:T88	11.67	Yes	No	0	6	7
57	R:R:Q99	R:R:T101	4.25	No	No	0	7	6
58	R:R:D103	R:R:S100	8.83	No	No	0	8	7
59	R:R:T101	R:R:T186	9.42	No	No	0	6	7
60	R:R:D103	R:R:V102	2.92	No	No	0	8	8
61	R:R:E166	R:R:V102	9.98	No	No	0	9	8
62	R:R:R183	R:R:Y104	7.2	No	No	0	4	4
63	R:R:K187	R:R:Y104	9.55	No	No	0	4	4
64	R:R:S162	R:R:Y105	8.9	No	Yes	0	7	8
65	R:R:L163	R:R:Y105	3.52	Yes	Yes	0	9	8
66	R:R:E166	R:R:Y105	7.86	No	Yes	0	9	8
67	R:R:M181	R:R:Y105	4.79	No	Yes	4	6	8
68	R:R:T186	R:R:Y105	4.99	No	Yes	0	7	8
69	R:R:F189	R:R:Y105	3.09	No	Yes	4	5	8
70	R:R:N159	R:R:S108	10.43	No	No	0	8	9
71	R:R:I190	R:R:S108	3.1	No	No	0	7	9
72	R:R:L109	R:R:N159	5.49	No	No	0	9	8
73	R:R:L109	R:R:N365	5.49	No	No	0	9	9
74	R:R:L111	R:R:W194	4.56	No	No	0	6	9
75	R:R:A155	R:R:S112	3.42	No	No	0	7	8
76	R:R:S112	R:R:T156	6.4	No	No	0	8	9
77	R:R:D113	R:R:T156	2.89	Yes	No	0	9	9
78	R:R:A362	R:R:D113	6.18	No	Yes	0	9	9
79	R:R:D113	R:R:N365	6.73	Yes	No	0	9	9
80	R:R:L115	R:R:L119	5.54	No	No	0	6	5
81	R:R:C152	R:R:L115	4.76	No	No	0	7	6
82	R:R:C152	R:R:I116	6.55	No	No	0	7	7
83	R:R:L117	R:R:Y359	4.69	No	Yes	0	6	7
84	R:R:L119	R:R:L148	4.15	No	No	0	5	5
85	R:R:A120	R:R:R149	4.15	No	Yes	0	6	7
86	R:R:A120	R:R:Y359	4	No	Yes	0	6	7
87	R:R:M121	R:R:P122	3.35	Yes	No	0	7	9
88	R:R:M121	R:R:Y359	14.37	Yes	Yes	1	7	7
89	R:R:E124	R:R:F128	22.15	Yes	Yes	1	7	6
90	R:R:E124	R:R:Y145	5.61	Yes	Yes	1	7	6
91	R:R:E124	R:R:Y351	10.1	Yes	Yes	1	7	4
92	R:R:E124	R:R:N355	6.57	Yes	Yes	1	7	6
93	R:R:E124	R:R:Y359	6.73	Yes	Yes	1	7	7
94	R:R:N127	R:R:Y126	5.81	Yes	No	0	5	4
95	R:R:N127	R:R:V131	4.43	Yes	No	0	5	5
96	R:R:F137	R:R:N127	8.46	Yes	Yes	0	7	5
97	R:R:F128	R:R:Y145	9.28	Yes	Yes	1	6	6
98	R:R:F128	R:R:Y146	4.13	Yes	Yes	1	6	5
99	R:R:F128	R:R:Y351	4.13	Yes	Yes	1	6	4
100	R:R:I129	R:R:M352	4.37	No	No	0	5	4
101	R:R:H133	R:R:P134	9.15	Yes	No	0	5	5
102	R:R:F137	R:R:W135	16.04	Yes	Yes	3	7	9
103	R:R:G138	R:R:W135	4.22	No	Yes	0	8	9
104	R:R:L210	R:R:W135	7.97	No	Yes	0	5	9
105	R:R:L223	R:R:W135	5.69	No	Yes	0	3	9
106	R:R:C225	R:R:W135	5.22	No	Yes	3	9	9
107	R:R:C142	R:R:F137	5.59	No	Yes	3	9	7
108	R:R:C225	R:R:F137	4.19	No	Yes	3	9	7
109	R:R:D139	R:R:L210	4.07	No	No	0	3	5
110	R:R:C142	R:R:M208	3.24	No	Yes	0	9	5
111	R:R:C142	R:R:C225	7.28	No	No	3	9	9
112	R:R:Y145	R:R:Y146	13.9	Yes	Yes	1	6	5
113	R:R:R149	R:R:Y145	7.2	Yes	Yes	1	7	6
114	R:R:R149	R:R:Y146	3.09	Yes	Yes	1	7	5
115	R:R:M208	R:R:Y146	8.38	Yes	Yes	0	5	5
116	R:R:F147	R:R:L205	8.53	No	No	0	5	5
117	R:R:R149	R:R:Y324	9.26	Yes	Yes	0	7	5
118	R:R:N355	R:R:R149	4.82	Yes	Yes	1	6	7
119	R:R:D150	R:R:Y154	6.9	Yes	Yes	6	6	6
120	R:R:A201	R:R:D150	3.09	No	Yes	0	7	6
121	R:R:D150	R:R:M204	11.09	Yes	No	0	6	6
122	R:R:D150	R:R:N241	6.73	Yes	No	6	6	5
123	R:R:T153	R:R:W321	8.49	No	Yes	0	7	8
124	R:R:L200	R:R:Y154	11.72	No	Yes	0	5	6
125	R:R:N241	R:R:Y154	9.3	No	Yes	6	5	6
126	R:R:S245	R:R:Y154	8.9	No	Yes	0	6	6
127	R:R:A155	R:R:W194	3.89	No	No	5	7	9
128	R:R:A155	R:R:S197	3.42	No	No	5	7	8
129	R:R:T156	R:R:W321	3.64	No	Yes	0	9	8
130	R:R:A157	R:R:S245	3.42	No	No	0	7	6
131	R:R:A157	R:R:P249	3.74	No	Yes	0	7	9
132	R:R:I193	R:R:L158	2.85	No	No	0	8	7
133	R:R:I193	R:R:N159	4.25	No	No	0	8	8
134	R:R:F317	R:R:V160	3.93	No	No	0	9	8
135	R:R:P249	R:R:V161	5.3	Yes	No	0	9	7
136	R:R:L163	R:R:R167	6.07	Yes	No	0	9	9
137	R:R:A253	R:R:S164	3.42	No	No	0	8	9
138	R:R:L256	R:R:S164	6.01	No	No	0	7	9
139	R:R:N257	R:R:S164	2.98	No	No	0	9	9
140	R:R:L256	R:R:V165	2.98	No	No	0	7	6
141	R:R:L310	R:R:R167	4.86	Yes	No	0	8	9
142	R:R:C172	R:R:Y168	6.72	No	Yes	0	7	8
143	R:R:H173	R:R:Y168	4.36	No	Yes	0	6	8
144	R:R:L256	R:R:Y168	15.24	No	Yes	0	7	8
145	R:R:V259	R:R:Y168	3.79	No	Yes	0	5	8
146	R:R:C172	R:R:K263	9.7	No	No	0	7	5
147	R:R:H173	R:R:K176	3.93	No	No	0	6	5
148	R:R:F189	R:R:M181	4.98	No	No	4	5	6
149	R:R:S182	R:R:S184	4.89	No	No	0	7	4
150	R:R:R185	R:R:S182	9.22	No	No	0	6	7
151	R:R:F189	R:R:R185	3.21	No	No	0	5	6
152	R:R:S197	R:R:W194	3.71	No	No	5	8	9
153	R:R:I202	R:R:P203	5.08	No	No	0	4	8
154	R:R:T207	R:R:V229	3.17	No	Yes	0	4	5
155	R:R:G209	R:R:M208	3.49	No	Yes	0	3	5
156	R:R:M208	R:R:P227	8.39	Yes	No	0	5	5
157	R:R:G209	R:R:I228	7.05	No	No	0	3	3
158	R:R:Q211	R:R:T226	4.25	No	No	0	3	3
159	R:R:I228	R:R:Q211	4.12	No	No	0	3	3
160	R:R:N212	R:R:S214	4.47	No	Yes	8	2	4
161	R:R:G217	R:R:N212	5.09	No	No	8	2	2
162	R:R:L223	R:R:N212	4.12	No	No	0	3	2
163	R:R:G215	R:R:S214	3.71	No	Yes	0	1	4
164	R:R:D216	R:R:S214	4.42	No	Yes	0	3	4
165	R:R:G217	R:R:S214	3.71	No	Yes	8	2	4
166	R:R:D216	R:R:T218	15.9	No	No	0	3	2
167	R:R:H219	R:R:P220	6.1	Yes	No	0	3	3
168	R:R:G221	R:R:H219	4.77	No	Yes	0	4	3
169	R:R:T226	R:R:V224	3.17	No	No	0	3	5
170	R:R:P227	R:R:T226	6.99	No	No	0	5	3
171	R:R:L234	R:R:P227	4.93	Yes	No	0	5	5
172	R:R:D230	R:R:V229	2.92	No	Yes	7	4	5
173	R:R:T233	R:R:V229	6.35	No	Yes	7	4	5
174	R:R:L234	R:R:V229	2.98	Yes	Yes	0	5	5
175	R:R:D230	R:R:T233	7.23	No	No	7	4	4
176	R:R:F331	R:R:L234	3.65	No	Yes	0	3	5
177	R:R:C332	R:R:L234	3.17	No	Yes	0	4	5
178	R:R:I238	R:R:V237	3.07	Yes	No	0	5	7
179	R:R:I238	R:R:R328	5.01	Yes	Yes	0	5	6
180	R:R:I238	R:R:L329	2.85	Yes	Yes	9	5	5
181	R:R:C332	R:R:I238	4.91	No	Yes	9	4	5
182	R:R:Q239	R:R:Y333	3.38	No	No	0	6	5
183	R:R:H325	R:R:T242	6.85	Yes	No	0	7	5
184	R:R:L329	R:R:T242	7.37	Yes	No	0	5	5
185	R:R:F243	R:R:M244	8.71	No	No	0	4	4
186	R:R:H325	R:R:S245	4.18	Yes	No	0	7	6
187	R:R:F246	R:R:L322	6.09	No	No	0	8	6
188	R:R:F246	R:R:H325	7.92	No	Yes	0	8	7
189	R:R:F248	R:R:P249	4.33	Yes	Yes	0	5	9
190	R:R:F248	R:R:L251	3.65	Yes	No	0	5	3
191	R:R:F248	R:R:V252	3.93	Yes	No	0	5	5
192	R:R:F317	R:R:P249	4.33	No	Yes	0	9	9
193	R:R:M250	R:R:V318	3.04	No	No	0	7	6
194	R:R:S254	R:R:V314	3.23	No	No	0	5	8
195	R:R:L310	R:R:N257	9.61	Yes	No	0	8	9
196	R:R:N257	R:R:V314	4.43	No	No	0	9	8
197	R:R:I260	R:R:L310	4.28	No	Yes	0	8	8
198	R:R:L264	R:R:V268	2.98	No	No	0	8	5
199	R:R:L264	R:R:L303	9.69	No	No	0	8	8
200	R:R:L264	R:R:V307	2.98	No	No	0	8	7
201	R:R:H269	R:R:T265	5.48	No	No	0	4	5
202	R:R:H269	R:R:V268	4.15	No	No	0	4	5
203	R:R:V268	R:R:V300	6.41	No	Yes	0	5	3
204	R:R:P297	R:R:T294	12.24	No	No	0	3	2
205	R:R:T294	R:R:V300	6.35	No	Yes	0	2	3
206	R:R:I295	R:R:R299	7.52	No	No	0	5	5
207	R:R:R299	R:R:V300	6.54	No	Yes	0	5	3
208	R:R:L303	R:R:R299	4.86	No	No	0	8	5
209	R:R:R304	R:R:V300	7.85	No	Yes	0	6	3
210	R:R:Q301	R:R:R304	11.68	No	No	0	5	6
211	R:R:R305	R:R:V372	3.92	No	No	0	8	7
212	R:R:G306	R:R:V309	3.68	No	No	0	8	8
213	R:R:V309	R:R:V372	3.21	No	No	0	8	7
214	R:R:A312	R:R:L368	4.73	No	Yes	0	6	8
215	R:R:L368	R:R:V313	4.47	Yes	No	0	8	8
216	R:R:V313	R:R:Y369	5.05	No	No	0	8	9
217	R:R:F317	R:R:W321	9.02	No	Yes	0	9	8
218	R:R:C320	R:R:S361	5.16	No	No	0	8	9
219	R:R:V358	R:R:W321	6.13	No	Yes	0	7	8
220	R:R:S361	R:R:W321	8.65	No	Yes	0	9	8
221	R:R:L322	R:R:P323	4.93	No	No	0	6	9
222	R:R:L322	R:R:V326	2.98	No	No	0	6	5
223	R:R:F350	R:R:P323	2.89	Yes	No	0	5	9
224	R:R:L357	R:R:P323	3.28	No	No	0	7	9
225	R:R:H325	R:R:Y324	7.62	Yes	Yes	0	7	5
226	R:R:R328	R:R:Y324	19.55	Yes	Yes	0	6	5
227	R:R:V358	R:R:Y324	5.05	No	Yes	0	7	5
228	R:R:R327	R:R:R328	4.26	Yes	Yes	0	5	6
229	R:R:R327	R:R:Y347	13.38	Yes	Yes	1	5	4
230	R:R:F350	R:R:R327	5.34	Yes	Yes	1	5	5
231	R:R:R327	R:R:Y351	12.35	Yes	Yes	1	5	4
232	R:R:R327	R:R:T354	6.47	Yes	No	1	5	5
233	R:R:C332	R:R:L329	4.76	No	Yes	9	4	5
234	R:R:L329	R:R:Y333	11.72	Yes	No	0	5	5
235	R:R:M330	R:R:Y347	3.59	No	Yes	0	5	4
236	R:R:F350	R:R:M330	6.22	Yes	No	0	5	5
237	R:R:F331	R:R:Y347	6.19	No	Yes	0	3	4
238	R:R:I334	R:R:Q338	6.86	No	No	0	3	1
239	R:R:I334	R:R:W339	22.31	No	Yes	0	3	7
240	R:R:E337	R:R:S335	4.31	No	No	0	2	3
241	R:R:E337	R:R:Q338	12.74	No	No	0	2	1
242	R:R:W339	R:R:Y347	8.68	Yes	Yes	1	7	4
243	R:R:L343	R:R:T340	11.79	No	No	0	2	7
244	R:R:F344	R:R:H348	15.84	Yes	Yes	1	3	4
245	R:R:H348	R:R:Y347	5.44	Yes	Yes	1	4	4
246	R:R:M352	R:R:Y349	4.79	No	No	0	4	1
247	R:R:F350	R:R:L353	3.65	Yes	No	0	5	5
248	R:R:F350	R:R:T354	7.78	Yes	No	1	5	5
249	R:R:N355	R:R:V358	4.43	Yes	No	0	6	7
250	R:R:N355	R:R:Y359	19.77	Yes	Yes	1	6	7
251	R:R:L357	R:R:V360	2.98	No	No	0	7	6
252	R:R:I364	R:R:V360	3.07	No	No	0	6	6
253	R:R:N365	R:R:S361	2.98	No	No	0	9	9
254	R:R:I364	R:R:I367	2.94	No	No	0	6	7
255	R:R:I367	R:R:L371	5.71	No	No	0	7	5
256	R:R:F376	R:R:N370	6.04	Yes	No	2	9	7
257	R:R:F380	R:R:N370	19.33	Yes	No	2	6	7
258	R:R:N375	R:R:S373	5.96	No	No	2	7	8
259	R:R:F376	R:R:S373	3.96	Yes	No	2	9	8
260	R:R:A374	R:R:R377	4.15	No	No	0	5	9
261	R:R:F376	R:R:N375	4.83	Yes	No	2	9	7
262	R:R:F376	R:R:F380	8.57	Yes	Yes	2	9	6
263	R:R:S382	R:R:V379	3.23	No	No	0	5	7
264	R:R:H219	R:R:S214	2.79	Yes	Yes	0	3	4
265	R:R:L106	R:R:L163	2.77	No	Yes	0	8	9
266	R:R:A201	R:R:F147	2.77	No	No	0	7	5
267	R:R:F380	R:R:V379	2.62	Yes	No	0	6	7
268	L:L:R2	R:R:T231	2.59	Yes	No	0	0	1
269	R:R:R311	R:R:T258	2.59	No	No	0	5	1
270	R:R:S63	R:R:Y62	2.54	No	No	0	2	3
271	R:R:V123	R:R:Y145	2.52	No	Yes	0	5	6
272	R:R:I116	R:R:R149	2.51	No	Yes	0	7	7
273	R:R:T186	R:R:Y104	2.5	No	No	0	7	4
274	R:R:F246	R:R:M250	2.49	No	No	0	8	7
275	R:R:F342	R:R:L343	2.44	No	No	0	3	2
276	R:R:I190	R:R:Y105	2.42	No	Yes	0	7	8
277	R:R:K235	R:R:Y333	2.39	No	No	0	4	5
278	R:R:L163	R:R:Y369	2.34	Yes	No	0	9	9
279	R:R:L343	R:R:W339	2.28	No	Yes	0	2	7
280	R:R:G221	R:R:G222	2.11	No	No	0	4	2
281	R:R:G81	R:R:P366	2.03	No	No	0	8	9
282	R:R:A363	R:R:G78	1.95	No	No	0	6	8
283	R:R:A110	R:R:G107	1.95	No	Yes	0	9	5
284	R:R:G78	R:R:V77	1.84	No	No	0	8	5
285	R:R:G81	R:R:V80	1.84	No	No	0	8	4
286	R:R:G81	R:R:V84	1.84	No	No	0	8	6
287	R:R:A151	R:R:A201	1.79	No	No	0	5	7
288	R:R:P203	R:R:V237	1.77	No	No	0	8	7
289	R:R:G78	R:R:L117	1.71	No	No	0	8	6
290	R:R:G107	R:R:L86	1.71	Yes	No	0	5	7
291	R:R:G107	R:R:L89	1.71	Yes	No	0	5	7
292	R:R:G107	R:R:L106	1.71	Yes	No	0	5	8
293	R:R:C320	R:R:V319	1.71	No	No	0	8	5
294	R:R:A261	R:R:V307	1.7	No	No	0	6	7
295	R:R:G298	R:R:Q301	1.64	No	No	0	3	5
296	R:R:T258	R:R:V259	1.59	No	No	0	1	5
297	R:R:A196	R:R:L158	1.58	No	No	0	5	7
298	R:R:A177	R:R:L169	1.58	No	No	0	6	4
299	R:R:A261	R:R:L310	1.58	No	Yes	0	6	8
300	R:R:A316	R:R:L368	1.58	No	Yes	0	5	8
301	R:R:E296	R:R:P297	1.57	No	No	0	5	3
302	R:R:A136	R:R:N127	1.56	No	Yes	0	4	5
303	R:R:A140	R:R:D139	1.54	No	No	0	1	3
304	R:R:A232	R:R:D230	1.54	No	No	0	3	4
305	R:R:I315	R:R:V314	1.54	No	No	0	5	8
306	R:R:H173	R:R:P174	1.53	No	No	0	6	9
307	R:R:M244	R:R:V240	1.52	No	No	0	4	4
308	R:R:I255	R:R:T258	1.52	No	No	0	4	1
309	R:R:K263	R:R:V266	1.52	No	No	0	5	5
310	R:R:F137	R:R:G141	1.51	Yes	No	0	7	4
311	R:R:F147	R:R:G144	1.51	No	No	0	5	4
312	R:R:L114	R:R:S83	1.5	No	No	0	8	4
313	R:R:G209	R:R:R143	1.5	No	No	0	3	7
314	R:R:L66	R:R:V67	1.49	No	No	0	5	5
315	R:R:L72	R:R:V76	1.49	No	No	0	3	5
316	R:R:L368	R:R:V309	1.49	Yes	No	0	8	8
317	R:R:N58	R:R:V57	1.48	No	Yes	0	3	2
318	R:R:L118	R:R:T79	1.47	No	No	0	5	6
319	R:R:I171	R:R:I260	1.47	No	No	0	8	8
320	R:R:N262	R:R:T265	1.46	No	No	0	5	5
321	R:R:I70	R:R:L66	1.43	No	No	0	4	5
322	R:R:I70	R:R:L74	1.43	No	No	0	4	7
323	R:R:Q378	R:R:V379	1.43	No	No	0	5	7
324	R:R:L125	R:R:M121	1.41	No	Yes	0	6	7
325	R:R:L180	R:R:M181	1.41	No	No	0	5	6
326	R:R:L247	R:R:M250	1.41	No	No	0	5	7
327	R:R:M293	R:R:N292	1.4	No	No	0	3	3
328	R:R:H133	R:R:S53	1.39	Yes	No	0	5	5
329	R:R:L169	R:R:L180	1.38	No	No	0	4	5
330	R:R:L199	R:R:L200	1.38	No	No	0	4	5
331	R:R:F75	R:R:V76	1.31	Yes	No	0	6	5
332	R:R:F342	R:R:T341	1.3	No	No	0	3	4
333	R:R:F175	R:R:K176	1.24	No	No	0	6	5
334	R:R:F248	R:R:M244	1.24	Yes	No	0	5	4
335	R:R:L308	R:R:R305	1.21	No	No	0	7	8
336	R:R:F346	R:R:F350	1.07	No	Yes	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R2	3.8075	4	1	0
2	L:L:P3	6.712	5	1	0
3	L:L:Y4	9.5025	4	0	0
4	L:L:L6	5.385	4	0	0
5	R:R:V57	4.28	6	1	2
6	R:R:Y71	5.582	5	1	7
7	R:R:F75	5.005	4	0	6
8	R:R:Y105	5.08143	7	4	8
9	R:R:G107	1.77	4	0	5
10	R:R:D113	4.96	4	0	9
11	R:R:M121	7.252	5	1	7
12	R:R:E124	10.232	5	1	7
13	R:R:N127	5.065	4	0	5
14	R:R:F128	9.696	5	1	6
15	R:R:H133	7.3325	4	0	5
16	R:R:W135	7.828	5	3	9
17	R:R:F137	7.158	5	3	7
18	R:R:Y145	7.702	5	1	6
19	R:R:Y146	7.072	5	1	5
20	R:R:R149	5.17167	6	1	7
21	R:R:D150	6.9525	4	6	6
22	R:R:Y154	9.205	4	6	6
23	R:R:L163	3.675	4	0	9
24	R:R:Y168	7.5275	4	0	8
25	R:R:M208	5.875	4	0	5
26	R:R:S214	3.82	5	8	4
27	R:R:H219	5.3275	4	0	3
28	R:R:V229	3.855	4	7	5
29	R:R:L234	3.6825	4	0	5
30	R:R:I238	3.96	4	9	5
31	R:R:F248	3.2875	4	0	5
32	R:R:P249	4.425	4	0	9
33	R:R:V300	6.7875	4	0	3
34	R:R:L310	5.0825	4	0	8
35	R:R:W321	7.186	5	0	8
36	R:R:Y324	10.37	4	0	5
37	R:R:H325	6.6425	4	0	7
38	R:R:R327	8.36	5	1	5
39	R:R:R328	8.7225	4	0	6
40	R:R:L329	6.675	4	9	5
41	R:R:W339	10.356	5	1	7
42	R:R:F344	8.3175	4	1	3
43	R:R:Y347	7.60333	6	1	4
44	R:R:H348	7.4675	4	1	4
45	R:R:F350	4.49167	6	1	5
46	R:R:Y351	6.988	5	1	4
47	R:R:N355	8.048	5	1	6
48	R:R:Y359	9.41833	6	1	7
49	R:R:L368	3.0675	4	0	8
50	R:R:F376	5.85	4	2	9
51	R:R:F380	8.55333	6	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H348	R:R:Y347	10.6713	5.44	Yes	Yes	1	4	4
2	R:R:R327	R:R:Y347	18.522	13.38	Yes	Yes	1	5	4
3	L:L:I5	L:L:Y4	12.7228	6.04	No	Yes	0	0	0
4	R:R:F331	R:R:Y347	11.4819	6.19	No	Yes	0	3	4
5	R:R:R327	R:R:R328	21.3731	4.26	Yes	Yes	0	5	6
6	R:R:M208	R:R:Y146	65.6404	8.38	Yes	Yes	0	5	5
7	R:R:C142	R:R:M208	63.1114	3.24	No	Yes	0	9	5
8	R:R:C142	R:R:F137	34.6677	5.59	No	Yes	3	9	7
9	R:R:F137	R:R:W135	25.9064	16.04	Yes	Yes	3	7	9
10	R:R:L223	R:R:W135	36.5749	5.69	No	Yes	0	3	9
11	R:R:L223	R:R:N212	33.5573	4.12	No	No	0	3	2
12	R:R:N212	R:R:S214	27.4804	4.47	No	Yes	8	2	4
13	R:R:H219	R:R:S214	15.3351	2.79	Yes	Yes	0	3	4
14	R:R:M208	R:R:P227	11.1099	8.39	Yes	No	0	5	5
15	R:R:C142	R:R:C225	27.1306	7.28	No	No	3	9	9
16	R:R:C225	R:R:W135	25.6704	5.22	No	Yes	3	9	9
17	R:R:M352	R:R:V67	11.604	9.13	No	No	0	4	5
18	R:R:V67	R:R:Y71	16.1679	3.79	No	Yes	0	5	7
19	R:R:E124	R:R:Y359	10.985	6.73	Yes	Yes	1	7	7
20	R:R:M121	R:R:Y359	12.112	14.37	Yes	Yes	1	7	7
21	R:R:F350	R:R:R327	10.9378	5.34	Yes	Yes	1	5	5
22	R:R:L117	R:R:Y359	13.9776	4.69	No	Yes	0	6	7
23	R:R:F75	R:R:M121	11.6346	9.95	Yes	Yes	0	6	7
24	R:R:R328	R:R:Y324	29.5486	19.55	Yes	Yes	0	6	5
25	R:R:V358	R:R:Y324	57.0679	5.05	No	Yes	0	7	5
26	R:R:V358	R:R:W321	100	6.13	No	Yes	0	7	8
27	R:R:T156	R:R:W321	27.1334	3.64	No	Yes	0	9	8
28	R:R:D113	R:R:T156	18.0529	2.89	Yes	No	0	9	9
29	R:R:D113	R:R:N82	17.109	4.04	Yes	No	0	9	9
30	R:R:N82	R:R:P366	13.8776	13.03	No	No	0	9	9
31	R:R:G81	R:R:P366	13.0837	2.03	No	No	0	8	9
32	R:R:G81	R:R:V84	11.7123	1.84	No	No	0	8	6
33	R:R:F380	R:R:V84	10.3659	5.24	Yes	No	0	6	6
34	R:R:S361	R:R:W321	72.4835	8.65	No	Yes	0	9	8
35	R:R:N365	R:R:S361	70.6263	2.98	No	No	0	9	9
36	R:R:L109	R:R:N365	71.5368	5.49	No	No	0	9	9
37	R:R:L109	R:R:N159	70.8067	5.49	No	No	0	9	8
38	R:R:N159	R:R:S108	67.8752	10.43	No	No	0	8	9
39	R:R:I190	R:R:S108	67.1839	3.1	No	No	0	7	9
40	R:R:I190	R:R:Y105	66.5094	2.42	No	Yes	0	7	8
41	R:R:L163	R:R:Y105	52.1737	3.52	Yes	Yes	0	9	8
42	R:R:R149	R:R:Y324	34.4512	9.26	Yes	Yes	0	7	5
43	R:R:R149	R:R:Y146	51.9904	3.09	Yes	Yes	1	7	5
44	R:R:H325	R:R:Y324	27.5998	7.62	Yes	Yes	0	7	5
45	R:R:H325	R:R:S245	17.7447	4.18	Yes	No	0	7	6
46	R:R:S245	R:R:Y154	16.5177	8.9	No	Yes	0	6	6
47	R:R:D150	R:R:Y154	10.5685	6.9	Yes	Yes	6	6	6
48	R:R:F317	R:R:W321	14.2524	9.02	No	Yes	0	9	8
49	R:R:F317	R:R:P249	12.2814	4.33	No	Yes	0	9	9
50	R:R:L163	R:R:R167	44.0647	6.07	Yes	No	0	9	9
51	R:R:L310	R:R:R167	43.082	4.86	Yes	No	0	8	9
52	R:R:L310	R:R:N257	22.7194	9.61	Yes	No	0	8	9
53	R:R:N257	R:R:S164	18.3443	2.98	No	No	0	9	9
54	R:R:L256	R:R:S164	16.1235	6.01	No	No	0	7	9
55	R:R:L256	R:R:Y168	13.8804	15.24	No	Yes	0	7	8
56	R:R:I238	R:R:R328	11.3736	5.01	Yes	Yes	0	5	6
57	R:R:A261	R:R:L310	19.341	1.58	No	Yes	0	6	8
58	R:R:A261	R:R:V307	18.2722	1.7	No	No	0	6	7
59	R:R:L264	R:R:V307	17.1617	2.98	No	No	0	8	7
60	R:R:L264	R:R:V268	12.6978	2.98	No	No	0	8	5
61	R:R:L163	R:R:Y369	11.629	2.34	Yes	No	0	9	9
62	R:R:V313	R:R:Y369	10.5158	5.05	No	No	0	8	9
63	R:R:N355	R:R:Y71	21.5424	4.65	Yes	Yes	1	6	7
64	R:R:W339	R:R:Y347	12.9338	8.68	Yes	Yes	1	7	4
65	R:R:N355	R:R:V358	51.6323	4.43	Yes	No	0	6	7
66	R:R:N355	R:R:R149	32.9104	4.82	Yes	Yes	1	6	7
67	R:R:N355	R:R:Y359	13.2447	19.77	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R1	R:R:F344	6.41	0	No	Yes	0	3	0	1
L:L:R2	R:R:D336	4.76	1	Yes	No	0	2	0	1
L:L:R2	R:R:W339	5	1	Yes	Yes	0	7	0	1
L:L:P3	R:R:W339	13.51	1	Yes	Yes	0	7	0	1
L:L:P3	R:R:F344	5.78	1	Yes	Yes	0	3	0	1
L:L:P3	R:R:Y347	8.34	1	Yes	Yes	0	4	0	1
L:L:P3	R:R:H348	3.05	1	Yes	Yes	0	4	0	1
L:L:Y4	R:R:L55	9.38	0	Yes	No	0	2	0	1
L:L:Y4	R:R:H133	8.71	0	Yes	Yes	0	5	0	1
L:L:Y4	R:R:V224	13.88	0	Yes	No	0	5	0	1
L:L:I5	R:R:F128	8.79	1	No	Yes	0	6	0	1
L:L:I5	R:R:Y351	4.84	1	No	Yes	0	4	0	1
L:L:L6	R:R:Y146	5.86	0	Yes	Yes	0	5	0	1
L:L:L6	R:R:R328	6.07	0	Yes	Yes	0	6	0	1
L:L:L6	R:R:F331	6.09	0	Yes	No	0	3	0	1
L:L:L6	R:R:Y351	3.52	0	Yes	Yes	0	4	0	1
R:R:D54	R:R:L55	4.07	0	No	No	4	2	2	1
R:R:D56	R:R:H133	10.08	0	No	Yes	2	5	2	1
R:R:F344	R:R:V57	5.24	1	Yes	Yes	3	2	1	2
R:R:H348	R:R:V57	5.54	1	Yes	Yes	4	2	1	2
R:R:E124	R:R:F128	22.15	1	Yes	Yes	7	6	2	1
R:R:E124	R:R:Y145	5.61	1	Yes	Yes	7	6	2	2
R:R:E124	R:R:Y351	10.1	1	Yes	Yes	7	4	2	1
R:R:F128	R:R:Y145	9.28	1	Yes	Yes	6	6	1	2
R:R:F128	R:R:Y146	4.13	1	Yes	Yes	6	5	1	1
R:R:F128	R:R:Y351	4.13	1	Yes	Yes	6	4	1	1
R:R:H133	R:R:P134	9.15	0	Yes	No	5	5	1	2
R:R:Y145	R:R:Y146	13.9	1	Yes	Yes	6	5	2	1
R:R:R149	R:R:Y145	7.2	1	Yes	Yes	7	6	2	2
R:R:R149	R:R:Y146	3.09	1	Yes	Yes	7	5	2	1
R:R:M208	R:R:Y146	8.38	0	Yes	Yes	5	5	2	1
R:R:R149	R:R:Y324	9.26	1	Yes	Yes	7	5	2	2
R:R:T226	R:R:V224	3.17	0	No	No	3	5	2	1
R:R:F331	R:R:L234	3.65	0	No	Yes	3	5	1	2
R:R:I238	R:R:R328	5.01	9	Yes	Yes	5	6	2	1
R:R:R328	R:R:Y324	19.55	0	Yes	Yes	6	5	1	2
R:R:R327	R:R:R328	4.26	1	Yes	Yes	5	6	2	1
R:R:R327	R:R:Y347	13.38	1	Yes	Yes	5	4	2	1
R:R:R327	R:R:Y351	12.35	1	Yes	Yes	5	4	2	1
R:R:M330	R:R:Y347	3.59	0	No	Yes	5	4	2	1
R:R:F331	R:R:Y347	6.19	0	No	Yes	3	4	1	1
R:R:I334	R:R:W339	22.31	0	No	Yes	3	7	2	1
R:R:W339	R:R:Y347	8.68	1	Yes	Yes	7	4	1	1
R:R:F344	R:R:H348	15.84	1	Yes	Yes	3	4	1	1
R:R:H348	R:R:Y347	5.44	1	Yes	Yes	4	4	1	1
L:L:R2	R:R:T231	2.59	1	Yes	No	0	1	0	1
R:R:L343	R:R:W339	2.28	0	No	Yes	2	7	2	1
R:R:H133	R:R:S53	1.39	0	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7L0P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	292
Number of Links	336
Number of Hubs	51
Number of Links mediated by Hubs	183
Number of Communities	9
Number of Nodes involved in Communities	48
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	77626
Length Of Smallest Path	3
Average Path Length	14.0733
Length of Longest Path	33
Minimum Path Strength	1.38
Average Path Strength	5.92517
Maximum Path Strength	17.91
Minimum Path Correlation	0.7
Average Path Correlation	0.943084
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	59.2083
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.8325
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• localization • macromolecule localization • intracellular protein localization • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • phototransduction • detection of light stimulus • response to light stimulus • detection of external stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • response to external stimulus • detection of abiotic stimulus • cell communication • detection of stimulus • response to radiation • signal transduction • G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • multicellular organismal process • cellular developmental process • sensory organ development • photoreceptor cell differentiation • visual system development • cell development • eye morphogenesis • multicellular organism development • neurogenesis • neuron differentiation • cell differentiation • eye photoreceptor cell differentiation • anatomical structure development • animal organ morphogenesis • sensory system development • system development • photoreceptor cell development • developmental process • eye photoreceptor cell development • eye development • animal organ development • nervous system development • generation of neurons • anatomical structure morphogenesis • sensory organ morphogenesis • neuron development • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular function activator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide activity • hormone activity • neuropeptide hormone activity • neuropeptide receptor binding • hepaticobiliary system development • gland development • liver development • locomotion involved in locomotory behavior • regulation of behavior • behavior • locomotory behavior • regulation of locomotion • regulation of locomotion involved in locomotory behavior • regulation of multicellular organismal process • locomotion • neuropeptide signaling pathway • response to stress • response to wounding • response to axon injury • cellular response to metal ion • response to lithium ion • cellular response to lithium ion • response to metal ion • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • digestive system development • tube development • digestive tract development • response to corticosteroid • response to steroid hormone • response to mineralocorticoid • positive regulation of cell communication • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of intracellular signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of response to stimulus • phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of signaling • response to light stimulus • learning • learning or memory • visual learning • visual behavior • cognition • associative learning • response to radiation • response to abiotic stimulus • cellular response to growth factor stimulus • cellular response to nerve growth factor stimulus • response to nerve growth factor • response to growth factor • cellular response to steroid hormone stimulus • cellular response to dexamethasone stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • response to dexamethasone • response to osmotic stress • hyperosmotic response • response to corticosterone • response to amine • response to amphetamine • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • blood circulation • regulation of anatomical structure size • response to antipsychotic drug • response to cocaine • response to alkaloid • response to estradiol • transport vesicle • intracellular vesicle • cytoplasmic vesicle • somatodendritic compartment • cell body • neuronal cell body • axon • axon terminus • presynapse • distal axon • neuron projection terminus • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled neurotensin receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • identical protein binding • positive regulation of locomotion • regulation of postsynaptic membrane potential • regulation of system process • chemical synaptic transmission, postsynaptic • positive regulation of inhibitory postsynaptic potential • positive regulation of nervous system process • modulation of inhibitory postsynaptic potential • trans-synaptic signaling • cell surface receptor signaling pathway • regulation of nervous system process • chemical synaptic transmission • anterograde trans-synaptic signaling • inhibitory postsynaptic potential • positive regulation of multicellular organismal process • regulation of membrane potential • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of arachidonate secretion • regulation of lipid transport • regulation of arachidonate secretion • arachidonate secretion • monocarboxylic acid transport • positive regulation of secretion • fatty acid transport • icosanoid transport • regulation of icosanoid secretion • icosanoid secretion • long-chain fatty acid transport • positive regulation of icosanoid secretion • organic anion transport • carboxylic acid transport • arachidonate transport • lipid localization • lipid transport • positive regulation of lipid localization • regulation of fatty acid transport • positive regulation of organic acid transport • organic acid transport • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • regulation of organic acid transport • positive regulation of fatty acid transport • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • inositol phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • alcohol catabolic process • catabolic process • polyol catabolic process • organophosphate catabolic process • inositol phosphate catabolic process • small molecule catabolic process • detection of external stimulus • detection of stimulus involved in sensory perception of pain • response to external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • detection of temperature stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • L-glutamate import across plasma membrane • import into cell • carboxylic acid transmembrane transport • import across plasma membrane • amino acid transmembrane transport • L-amino acid transport • L-glutamate import • transmembrane transport • amino acid transport • acidic amino acid transport • dicarboxylic acid transport • L-alpha-amino acid transmembrane transport • amino acid import across plasma membrane • L-glutamate transmembrane transport • ribose phosphate metabolic process • nucleotide biosynthetic process • carbohydrate derivative metabolic process • purine ribonucleotide biosynthetic process • cAMP biosynthetic process • cyclic nucleotide metabolic process • nucleobase-containing compound metabolic process • ribonucleotide biosynthetic process • purine nucleotide metabolic process • ribonucleotide metabolic process • nucleobase-containing small molecule metabolic process • purine-containing compound biosynthetic process • cyclic nucleotide biosynthetic process • ribose phosphate biosynthetic process • nucleoside phosphate metabolic process • carbohydrate derivative biosynthetic process • cAMP metabolic process • cyclic purine nucleotide metabolic process • nucleotide metabolic process • nucleobase-containing compound biosynthetic process • purine-containing compound metabolic process • nucleoside phosphate biosynthetic process • purine ribonucleotide metabolic process • purine nucleotide biosynthetic process • conditioned place preference • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • positive regulation of phosphate metabolic process • positive regulation of phosphorus metabolic process • positive regulation of inositol phosphate biosynthetic process • positive regulation of carbohydrate metabolic process • adult locomotory behavior • adult behavior • regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • negative regulation of cation transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • maintenance of location • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • negative regulation of calcium ion transmembrane transport • cellular localization • inorganic ion homeostasis • homeostatic process • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • negative regulation of transmembrane transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of sequestering of calcium ion • negative regulation of monoatomic ion transmembrane transport • negative regulation of release of sequestered calcium ion into cytosol • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • monoatomic ion transport • intracellular chemical homeostasis • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • negative regulation of calcium ion transport • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • negative regulation of programmed cell death • negative regulation of apoptotic process • regulation of defense response • behavioral fear response • defense response • regulation of fear response • multicellular organismal response to stress • regulation of behavioral fear response • behavioral defense response • fear response • regulation of response to stress • aspartate transmembrane transport • C4-dicarboxylate transport • D-amino acid transport • D-aspartate transmembrane transport • D-aspartate import across plasma membrane • regulation of membrane depolarization • membrane depolarization • multicellular organismal-level homeostasis • temperature homeostasis • regulation of systemic arterial blood pressure • regulation of blood pressure • negative regulation of systemic arterial blood pressure • negative regulation of blood pressure • positive regulation of amine transport • gamma-aminobutyric acid transport • regulation of amino acid transport • gamma-aminobutyric acid secretion • regulation of gamma-aminobutyric acid secretion • positive regulation of gamma-aminobutyric acid secretion • acid secretion • amine transport • positive regulation of amino acid transport • regulation of amine transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • vocalization behavior • regulation of glutamate secretion • positive regulation of secretion by cell • glutamate secretion • positive regulation of glutamate secretion • response to nutrient levels • response to food • perikaryon • dendrite • dendritic tree • dendritic shaft • neuron spine • dendritic spine • postsynapse • symmetric synapse • neuron to neuron synapse • terminal bouton • cell surface • membrane microdomain • membrane raft
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P20789
Sequence	>7L0P_nogp_Chain_R N S D L D V N T D I Y S K V L V T A I Y L A L F V V G T V G N S V T L F T L A R L Q S T V D Y Y L G S L A L S D L L I L L L A M P V E L Y N F I W V H H P W A F G D A G C R G Y Y F L R D A C T Y A T A L N V V S L S V E R Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A I P M L F T M G L Q N L S G D G T H P G G L V C T P I V D T A T L K V V I Q V N T F M S F L F P M L V A S I L N T V I A N K L T V M V H Q A A N M T I E P G R V Q A L R R G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I S D E Q W T T F L F D F Y H Y F Y M L T N A L V Y V S A A I N P I L Y N L V S A N F R Q V F L S T L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg	Gq; GRK2	3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPB (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg		3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg	Gq; GRK2	3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPC (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg		3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	SBI-553	chim(NtGi1-Go)/β1/γ2	2.89	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN0 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	SBI-553		2.89	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	SBI-553	-	3.02	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8ZYT	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.65	2025-04-09	doi.org/10.1038/s41422-025-01095-7
	8ZYY	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.83	2025-04-09	doi.org/10.1038/s41422-025-01095-7
	8ZYU	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.65	2025-04-16	doi.org/10.1038/s41422-025-01095-7
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.59	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FMZ (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.59	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi1-Go)/β1/γ2	2.88	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN1 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.88	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin-(8-13)	-	-	2.8	2012-10-17	doi.org/10.1038/nature11558
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	doi.org/10.1038/ncomms8895
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	doi.org/10.1038/ncomms8895
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	doi.org/10.1038/s41422-019-0256-2
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OS9 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OSA (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	doi.org/10.1038/s41586-020-1953-1
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.1	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0P (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.1	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.3	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0Q (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.3	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.2	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0R (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.2	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.5	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0S (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.5	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	doi.org/10.1038/srep38564
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	doi.org/10.1073/pnas.1317903111
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	doi.org/10.1126/sciadv.abe5504
	9M0D	A	Peptide	Neurotensin	NTS₁	Homo sapiens	-	-	Arrestin2	3.41	2025-04-09	doi.org/10.1038/s41422-025-01095-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7L0P_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.