psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	I:I:?1	I:I:?2	9.64	No	No	17	0	0
2	I:I:?2	O:O:?1	13.58	No	No	17	0	0
3	I:I:?1	O:O:?1	11.56	No	No	17	0	0
4	K:K:A6	K:K:D3	4.63	No	Yes	0	9	9
5	K:K:D3	R:R:S368	7.36	Yes	No	0	9	8
6	K:K:D3	R:R:N370	8.08	Yes	No	0	9	7
7	K:K:L4	K:K:L8	6.92	No	No	0	9	9
8	K:K:L4	R:R:G301	3.42	No	No	0	9	8
9	K:K:L4	W:W:?1	8.51	No	Yes	0	9	0
10	K:K:E5	R:R:H102	4.92	No	No	0	9	8
11	K:K:E5	W:W:?1	11.77	No	Yes	0	9	0
12	K:K:V7	R:R:R294	7.85	Yes	No	0	9	4
13	K:K:V7	R:R:A297	5.09	Yes	No	0	9	6
14	K:K:V7	R:R:L298	4.47	Yes	No	0	9	7
15	K:K:L8	R:R:R166	3.64	No	No	0	9	9
16	K:K:L8	R:R:I170	4.28	No	No	0	9	9
17	K:K:D10	K:K:R195	9.53	No	Yes	3	9	9
18	K:K:D10	K:K:V477	4.38	No	Yes	3	9	8
19	K:K:D10	R:R:R294	8.34	No	No	0	9	4
20	K:K:V11	R:R:M266	4.56	No	No	0	9	6
21	K:K:M17	K:K:Y13	10.78	No	Yes	0	9	9
22	K:K:H194	K:K:Y13	11.98	Yes	Yes	0	9	9
23	K:K:R195	K:K:Y13	4.12	Yes	Yes	3	9	9
24	K:K:I197	K:K:Y13	3.63	No	Yes	3	9	9
25	K:K:L273	K:K:Y13	3.52	No	Yes	0	7	9
26	K:K:V477	K:K:Y13	5.05	Yes	Yes	3	8	9
27	K:K:A16	K:K:H194	4.39	No	Yes	0	9	9
28	K:K:M17	K:K:M216	5.78	No	No	0	9	9
29	K:K:M17	K:K:N275	7.01	No	No	0	9	9
30	K:K:K19	K:K:S20	4.59	No	No	0	8	8
31	K:K:K19	K:K:R27	4.95	No	No	0	8	7
32	K:K:K19	K:K:R209	3.71	No	Yes	0	8	9
33	K:K:A26	K:K:S20	3.42	No	No	0	8	8
34	K:K:A26	K:K:T23	3.36	No	No	0	8	6
35	K:K:R209	K:K:S29	6.59	Yes	No	0	9	8
36	K:K:S29	R:R:F174	13.21	No	Yes	0	8	7
37	K:K:A211	K:K:K30	4.82	No	No	0	8	9
38	K:K:D212	K:K:K30	6.91	No	No	0	8	9
39	K:K:E532	K:K:K31	9.45	No	No	0	4	6
40	K:K:L34	K:K:P35	3.28	Yes	Yes	1	8	5
41	K:K:L34	K:K:Q176	5.32	Yes	No	1	8	9
42	K:K:L34	K:K:W177	14.81	Yes	Yes	1	8	9
43	K:K:I529	K:K:L34	4.28	Yes	Yes	1	5	8
44	K:K:L34	K:K:T533	8.84	Yes	No	1	8	5
45	K:K:I39	K:K:P35	8.47	No	Yes	1	7	5
46	K:K:P35	K:K:Q176	4.74	Yes	No	1	5	9
47	K:K:N179	K:K:P35	4.89	Yes	Yes	1	6	5
48	K:K:E36	K:K:P37	4.72	No	No	0	7	5
49	K:K:E36	K:K:K540	5.4	No	No	0	7	4
50	K:K:E537	K:K:P37	4.72	No	No	0	7	5
51	K:K:S38	K:K:Y580	5.09	No	Yes	0	8	8
52	K:K:I39	K:K:N179	7.08	No	Yes	1	7	6
53	K:K:E639	K:K:I39	6.83	Yes	No	1	6	7
54	K:K:Q44	K:K:R40	5.84	No	No	18	4	7
55	K:K:F171	K:K:R40	8.55	Yes	No	18	5	7
56	K:K:R40	K:K:T172	14.23	No	No	0	7	6
57	K:K:H562	K:K:S41	13.95	Yes	No	0	7	5
58	K:K:M561	K:K:V42	6.09	Yes	No	0	4	7
59	K:K:L47	K:K:M43	4.24	No	No	0	5	4
60	K:K:M43	K:K:N179	9.82	No	Yes	0	4	6
61	K:K:M43	K:K:P638	3.35	No	Yes	0	4	8
62	K:K:E48	K:K:Q44	7.65	No	No	0	4	4
63	K:K:F171	K:K:Q44	4.68	Yes	No	18	5	4
64	K:K:K45	K:K:M561	4.32	No	Yes	7	6	4
65	K:K:K45	K:K:Q642	4.07	No	Yes	7	6	8
66	K:K:E646	K:K:K45	8.1	No	No	7	8	6
67	K:K:R50	K:K:Y46	18.52	No	Yes	0	3	4
68	K:K:L182	K:K:Y46	4.69	No	Yes	7	8	4
69	K:K:P638	K:K:Y46	9.74	Yes	Yes	7	8	4
70	K:K:Q642	K:K:Y46	7.89	Yes	Yes	7	8	4
71	K:K:E52	K:K:L47	7.95	No	No	0	5	5
72	K:K:D49	K:K:Q642	9.14	No	Yes	0	4	8
73	K:K:D49	K:K:K645	8.3	No	No	0	4	4
74	K:K:E52	K:K:R50	3.49	No	No	0	5	3
75	K:K:E52	K:K:K178	5.4	No	No	0	5	9
76	K:K:K57	K:K:T54	4.5	No	No	0	5	4
77	K:K:E56	K:K:F55	4.66	No	Yes	5	3	7
78	K:K:F55	K:K:F59	15	Yes	Yes	5	7	7
79	K:K:F55	K:K:L157	3.65	Yes	No	0	7	8
80	K:K:F55	K:K:R158	8.55	Yes	No	5	7	5
81	K:K:F162	K:K:F55	11.79	Yes	Yes	0	8	7
82	K:K:E56	K:K:R158	8.14	No	No	5	3	5
83	K:K:F162	K:K:I58	5.02	Yes	No	0	8	7
84	K:K:F174	K:K:I58	7.54	Yes	No	0	7	7
85	K:K:F59	K:K:Y65	9.28	Yes	Yes	5	7	5
86	K:K:F59	K:K:F68	5.36	Yes	Yes	0	7	8
87	K:K:F59	K:K:Y86	10.32	Yes	Yes	5	7	7
88	K:K:F174	K:K:Q61	5.86	Yes	No	0	7	9
89	K:K:K178	K:K:Q61	6.78	No	No	0	9	9
90	K:K:Q518	K:K:Q61	12.8	Yes	No	0	9	9
91	K:K:K62	K:K:L66	4.23	No	No	0	5	3
92	K:K:K62	K:K:Q519	6.78	No	No	0	5	4
93	K:K:L63	K:K:W177	4.56	No	Yes	1	7	9
94	K:K:L63	K:K:Q518	9.32	No	Yes	1	7	9
95	K:K:F526	K:K:L63	12.18	Yes	No	1	8	7
96	K:K:R69	K:K:Y65	4.12	No	Yes	5	6	5
97	K:K:Y65	K:K:Y86	3.97	Yes	Yes	5	5	7
98	K:K:E87	K:K:Y65	6.73	No	Yes	5	6	5
99	K:K:F526	K:K:L66	4.87	Yes	No	0	8	3
100	K:K:L67	K:K:R173	4.86	No	Yes	0	8	9
101	K:K:F174	K:K:L67	3.65	Yes	No	0	7	8
102	K:K:F526	K:K:L67	3.65	Yes	No	0	8	8
103	K:K:C72	K:K:F68	8.38	No	Yes	0	7	8
104	K:K:F68	K:K:L157	7.31	Yes	No	0	8	8
105	K:K:F165	K:K:F68	12.86	No	Yes	0	6	8
106	K:K:L73	K:K:R69	7.29	No	No	0	3	6
107	K:K:E87	K:K:R69	15.12	No	No	5	6	6
108	K:K:D70	K:K:K74	12.44	No	No	0	5	4
109	K:K:D70	K:K:K170	9.68	No	No	0	5	5
110	K:K:F71	K:K:H75	4.53	Yes	No	12	5	1
111	K:K:F71	K:K:L76	3.65	Yes	Yes	12	5	2
112	K:K:F165	K:K:F71	7.5	No	Yes	0	6	5
113	K:K:F71	K:K:S168	7.93	Yes	No	0	5	9
114	K:K:F71	K:K:K170	4.96	Yes	No	12	5	5
115	K:K:A79	K:K:C72	3.61	No	No	0	4	7
116	K:K:C72	K:K:V83	5.12	No	No	0	7	5
117	K:K:L73	K:K:V83	4.47	No	No	0	3	5
118	K:K:E84	K:K:L73	10.6	No	No	0	1	3
119	K:K:H75	K:K:K74	3.93	No	No	0	1	4
120	K:K:H75	K:K:K170	9.17	No	No	12	1	5
121	K:K:E78	K:K:L76	5.3	No	Yes	0	3	2
122	K:K:A79	K:K:L76	4.73	No	Yes	12	4	2
123	K:K:L76	K:K:V161	4.47	Yes	No	12	2	5
124	K:K:A79	K:K:V161	3.39	No	No	12	4	5
125	K:K:K80	K:K:P81	3.35	No	No	0	3	3
126	K:K:E84	K:K:K80	5.4	No	No	0	1	3
127	K:K:F85	K:K:I89	11.3	Yes	No	0	8	7
128	K:K:F85	K:K:I108	3.77	Yes	Yes	5	8	5
129	K:K:F85	K:K:Y112	18.57	Yes	No	0	8	3
130	K:K:F85	K:K:I113	3.77	Yes	Yes	5	8	5
131	K:K:F124	K:K:F85	4.29	Yes	Yes	5	3	8
132	K:K:F85	K:K:Y149	9.28	Yes	Yes	5	8	4
133	K:K:F85	K:K:I153	6.28	Yes	No	5	8	5
134	K:K:K90	K:K:Y86	11.94	No	Yes	0	4	7
135	K:K:I150	K:K:Y86	4.84	No	Yes	0	2	7
136	K:K:I153	K:K:Y86	3.63	No	Yes	5	5	7
137	K:K:E88	K:K:I108	4.1	No	Yes	0	4	5
138	K:K:E88	K:K:Y112	12.35	No	No	0	4	3
139	K:K:F146	K:K:I89	11.3	Yes	No	0	8	7
140	K:K:I150	K:K:I89	7.36	No	No	0	2	7
141	K:K:E93	K:K:K90	5.4	No	No	0	7	4
142	K:K:R101	K:K:Y92	11.32	Yes	Yes	5	7	5
143	K:K:C104	K:K:Y92	5.38	No	Yes	0	1	5
144	K:K:I108	K:K:Y92	3.63	Yes	Yes	5	5	5
145	K:K:L145	K:K:Y92	7.03	Yes	Yes	5	4	5
146	K:K:F146	K:K:Y92	7.22	Yes	Yes	5	8	5
147	K:K:E93	K:K:Q147	6.37	No	No	0	7	3
148	K:K:E100	K:K:L95	9.28	No	No	0	4	3
149	K:K:L95	K:K:R101	4.86	No	Yes	0	3	7
150	K:K:E96	K:K:T97	4.23	No	No	0	5	2
151	K:K:E99	K:K:T97	7.06	No	No	0	5	2
152	K:K:E98	K:K:R101	6.98	No	Yes	5	3	7
153	K:K:E98	K:K:V141	5.7	No	No	5	3	3
154	K:K:R101	K:K:V141	3.92	Yes	No	5	7	3
155	K:K:P143	K:K:R101	10.09	No	Yes	0	3	7
156	K:K:K139	K:K:L102	8.46	No	No	0	1	1
157	K:K:L102	K:K:V141	4.47	No	No	0	1	3
158	K:K:L136	K:K:S105	6.01	No	No	0	4	6
159	K:K:F146	K:K:S105	3.96	Yes	No	0	8	6
160	K:K:D110	K:K:R106	5.96	No	No	0	3	4
161	K:K:F146	K:K:I108	7.54	Yes	Yes	5	8	5
162	K:K:F109	K:K:I113	12.56	Yes	Yes	0	3	5
163	K:K:F109	K:K:M114	4.98	Yes	No	0	3	4
164	K:K:F109	K:K:Q133	3.51	Yes	Yes	0	3	3
165	K:K:F109	K:K:L136	4.87	Yes	No	0	3	4
166	K:K:T111	K:K:Y112	13.73	No	No	0	1	3
167	K:K:H122	K:K:I113	6.63	Yes	Yes	5	3	5
168	K:K:I113	K:K:Y149	8.46	Yes	Yes	5	5	4
169	K:K:E116	K:K:K115	10.8	No	No	0	4	2
170	K:K:E116	K:K:H122	7.39	No	Yes	0	4	3
171	K:K:H122	K:K:L117	6.43	Yes	No	0	3	4
172	K:K:A119	K:K:S121	3.42	No	No	0	3	4
173	K:K:H122	K:K:P123	4.58	Yes	No	5	3	1
174	K:K:F124	K:K:H122	13.58	Yes	Yes	5	3	3
175	K:K:H122	K:K:I129	3.98	Yes	Yes	5	3	2
176	K:K:H122	K:K:Y149	6.53	Yes	Yes	5	3	4
177	K:K:F124	K:K:P123	5.78	Yes	No	5	3	1
178	K:K:F124	K:K:Y149	14.44	Yes	Yes	5	3	4
179	K:K:E152	K:K:F124	10.49	No	Yes	0	3	3
180	K:K:F124	K:K:I153	6.28	Yes	No	5	3	5
181	K:K:E152	K:K:S125	8.62	No	No	0	3	3
182	K:K:A128	K:K:Y149	8.01	No	Yes	0	2	4
183	K:K:I129	K:K:Q133	4.12	Yes	Yes	0	2	3
184	K:K:I129	K:K:Y149	4.84	Yes	Yes	5	2	4
185	K:K:E130	K:K:Q133	3.82	No	Yes	0	1	3
186	K:K:H131	K:K:H135	14.33	No	No	0	1	1
187	K:K:H131	K:K:P148	7.63	No	No	0	1	2
188	K:K:F146	K:K:V132	3.93	Yes	No	0	8	5
189	K:K:V132	K:K:Y149	3.79	No	Yes	0	5	4
190	K:K:H135	K:K:Q140	6.18	No	No	0	1	2
191	K:K:H135	K:K:L145	3.86	No	Yes	0	1	4
192	K:K:K138	K:K:Q140	9.49	No	No	0	2	2
193	K:K:D144	K:K:P142	9.66	No	No	0	3	3
194	K:K:L145	K:K:P142	6.57	Yes	No	0	4	3
195	K:K:F146	K:K:L145	6.09	Yes	Yes	5	8	4
196	K:K:Q155	K:K:R158	7.01	No	No	0	1	5
197	K:K:F162	K:K:I166	8.79	Yes	No	0	8	4
198	K:K:F165	K:K:F171	5.36	No	Yes	0	6	5
199	K:K:C175	K:K:F171	6.98	No	Yes	0	7	5
200	K:K:Q176	K:K:R173	7.01	No	Yes	1	9	9
201	K:K:R173	K:K:W177	4	Yes	Yes	1	9	9
202	K:K:N530	K:K:R173	10.85	No	Yes	1	9	9
203	K:K:R173	K:K:T533	9.06	Yes	No	1	9	5
204	K:K:D534	K:K:R173	9.53	No	Yes	0	6	9
205	K:K:E537	K:K:R173	4.65	No	Yes	1	7	9
206	K:K:V521	K:K:W177	3.68	No	Yes	0	8	9
207	K:K:F526	K:K:W177	13.03	Yes	Yes	1	8	9
208	K:K:I529	K:K:W177	5.87	Yes	Yes	1	5	9
209	K:K:N530	K:K:W177	7.91	No	Yes	1	9	9
210	K:K:E181	K:K:K178	9.45	Yes	No	0	9	9
211	K:K:N179	K:K:S636	8.94	Yes	No	1	6	7
212	K:K:E639	K:K:N179	5.26	Yes	Yes	1	6	6
213	K:K:E181	K:K:S514	7.19	Yes	No	1	9	7
214	K:K:E181	K:K:W517	14.17	Yes	Yes	1	9	9
215	K:K:E181	K:K:Q518	5.1	Yes	Yes	1	9	9
216	K:K:L182	K:K:P638	8.21	No	Yes	7	8	8
217	K:K:H185	K:K:N183	5.1	No	No	0	5	6
218	K:K:N183	K:K:S636	8.94	No	No	0	6	7
219	K:K:I184	K:K:W517	7.05	No	Yes	0	6	9
220	K:K:D637	K:K:H185	8.82	No	No	0	5	5
221	K:K:D190	K:K:L186	4.07	No	Yes	0	8	8
222	K:K:F191	K:K:L186	7.31	Yes	Yes	1	9	8
223	K:K:L186	K:K:Y259	4.69	Yes	Yes	1	8	9
224	K:K:F261	K:K:L186	9.74	No	Yes	1	8	8
225	K:K:D190	K:K:T187	5.78	No	No	0	8	7
226	K:K:M188	K:K:M219	4.33	No	Yes	0	8	8
227	K:K:M188	K:K:T263	4.52	No	No	0	8	9
228	K:K:C208	K:K:F191	6.98	No	Yes	1	9	9
229	K:K:F191	K:K:K210	8.69	Yes	Yes	1	9	8
230	K:K:F191	K:K:M219	4.98	Yes	Yes	1	9	8
231	K:K:F191	K:K:F261	4.29	Yes	No	1	9	8
232	K:K:F191	K:K:I270	10.05	Yes	Yes	1	9	8
233	K:K:R209	K:K:S192	5.27	Yes	No	0	9	9
234	K:K:S192	R:R:F174	3.96	No	Yes	0	9	7
235	K:K:V193	K:K:Y206	5.05	No	Yes	0	7	8
236	K:K:H194	K:K:M216	3.94	Yes	No	0	9	9
237	K:K:R195	K:K:V477	10.46	Yes	Yes	3	9	8
238	K:K:E204	K:K:I196	4.1	Yes	Yes	19	9	9
239	K:K:I196	K:K:Y206	6.04	Yes	Yes	19	9	8
240	K:K:I196	K:K:I485	7.36	Yes	No	0	9	9
241	K:K:I197	K:K:V205	4.61	No	No	3	9	9
242	K:K:?701	K:K:I197	19.41	Yes	No	3	0	9
243	K:K:G198	K:K:I485	3.53	No	No	0	9	9
244	K:K:?701	K:K:G198	7.4	Yes	No	0	0	9
245	K:K:E204	K:K:R199	3.49	Yes	Yes	0	9	9
246	K:K:F488	K:K:R199	11.76	No	Yes	0	9	9
247	K:K:F202	K:K:L222	3.65	Yes	No	0	9	9
248	K:K:F202	K:K:I227	5.02	Yes	No	0	9	8
249	K:K:F202	K:K:K230	8.69	Yes	No	0	9	9
250	K:K:F202	K:K:G232	4.52	Yes	No	0	9	8
251	K:K:E204	K:K:G203	4.91	Yes	No	0	9	9
252	K:K:E204	K:K:Y206	12.35	Yes	Yes	19	9	8
253	K:K:K220	K:K:V205	4.55	Yes	No	3	9	9
254	K:K:?701	K:K:V205	24.86	Yes	No	3	0	9
255	K:K:C221	K:K:Y206	4.03	No	Yes	0	9	8
256	K:K:C208	K:K:M219	4.86	No	Yes	1	9	8
257	K:K:G214	K:K:R209	4.5	No	Yes	0	9	9
258	K:K:D212	K:K:K210	12.44	No	Yes	1	8	8
259	K:K:K210	K:K:T213	7.51	Yes	Yes	1	8	9
260	K:K:K210	K:K:Y217	3.58	Yes	Yes	1	8	9
261	K:K:K210	K:K:Y259	9.55	Yes	Yes	1	8	9
262	K:K:E520	K:K:K210	10.8	Yes	Yes	1	9	8
263	K:K:D212	K:K:T213	5.78	No	Yes	1	8	9
264	K:K:E520	K:K:T213	14.11	Yes	Yes	1	9	9
265	K:K:T213	K:K:T524	6.28	Yes	No	0	9	8
266	K:K:K215	K:K:Y217	15.53	No	Yes	1	9	9
267	K:K:E520	K:K:K215	6.75	Yes	No	1	9	9
268	K:K:L273	K:K:M216	4.24	No	No	0	7	9
269	K:K:S258	K:K:Y217	8.9	No	Yes	1	8	9
270	K:K:Y217	K:K:Y259	3.97	Yes	Yes	1	9	9
271	K:K:I270	K:K:Y217	8.46	Yes	Yes	1	8	9
272	K:K:E520	K:K:Y217	10.1	Yes	Yes	1	9	9
273	K:K:?701	K:K:A218	5.84	Yes	No	0	0	9
274	K:K:M219	K:K:S268	7.67	Yes	No	0	8	8
275	K:K:I270	K:K:M219	4.37	Yes	Yes	1	8	8
276	K:K:K220	K:K:L222	5.64	Yes	No	0	9	9
277	K:K:E239	K:K:K220	5.4	Yes	Yes	3	9	9
278	K:K:?701	K:K:K220	8.72	Yes	Yes	3	0	9
279	K:K:C221	K:K:S268	3.44	No	No	0	9	8
280	K:K:F269	K:K:L222	3.65	Yes	No	0	8	9
281	K:K:D223	K:K:K225	5.53	No	No	0	9	9
282	K:K:D223	K:K:R226	5.96	No	Yes	0	9	9
283	K:K:D223	K:K:K266	8.3	No	No	0	9	6
284	K:K:H262	K:K:K224	6.55	Yes	Yes	3	8	9
285	K:K:K224	K:K:L267	7.05	Yes	Yes	3	9	9
286	K:K:K224	K:K:Q503	10.85	Yes	No	0	9	4
287	K:K:K224	K:K:Y506	8.36	Yes	Yes	3	9	9
288	K:K:K225	K:K:T493	6.01	No	No	0	9	8
289	K:K:F488	K:K:R226	16.03	No	Yes	0	9	9
290	K:K:R226	K:K:T493	3.88	Yes	No	0	9	8
291	K:K:I227	K:K:Y506	3.63	No	Yes	0	8	9
292	K:K:I496	K:K:K228	4.36	No	No	0	8	9
293	K:K:D502	K:K:K228	8.3	No	No	0	9	9
294	K:K:K230	K:K:M229	4.32	No	No	0	9	8
295	K:K:I496	K:K:M229	4.37	No	No	0	8	8
296	K:K:E233	K:K:L505	5.3	No	No	3	9	8
297	K:K:E233	K:K:Y506	3.37	No	Yes	3	9	9
298	K:K:M242	K:K:N238	9.82	No	No	0	8	8
299	K:K:E239	K:K:L243	3.98	Yes	Yes	3	9	9
300	K:K:E239	K:K:F269	9.33	Yes	Yes	3	9	8
301	K:K:E239	K:K:G337	4.91	Yes	No	0	9	9
302	K:K:F269	K:K:R240	4.28	Yes	Yes	3	8	9
303	K:K:F509	K:K:R240	8.55	Yes	Yes	3	9	9
304	K:K:L511	K:K:R240	7.29	No	Yes	0	7	9
305	K:K:M242	K:K:V313	4.56	No	Yes	0	8	8
306	K:K:L243	K:K:M257	12.72	Yes	No	0	9	9
307	K:K:F269	K:K:L243	4.87	Yes	Yes	3	8	9
308	K:K:L243	K:K:L336	4.15	Yes	No	0	9	9
309	K:K:L245	K:K:R311	4.86	No	No	0	8	6
310	K:K:C256	K:K:S247	3.44	No	No	1	7	9
311	K:K:I513	K:K:S247	6.19	No	No	1	7	9
312	K:K:R516	K:K:S247	3.95	Yes	No	1	9	9
313	K:K:E515	K:K:T248	4.23	No	No	0	8	7
314	K:K:C251	K:K:P252	3.77	No	Yes	4	8	7
315	K:K:C251	K:K:F253	4.19	No	Yes	4	8	9
316	K:K:C251	K:K:H307	16.22	No	No	0	8	8
317	K:K:F253	K:K:P252	8.67	Yes	Yes	4	9	7
318	K:K:P252	K:K:Q464	6.32	Yes	Yes	4	7	5
319	K:K:E300	K:K:F253	15.16	Yes	Yes	4	9	9
320	K:K:F253	K:K:L303	10.96	Yes	Yes	4	9	7
321	K:K:F253	K:K:Q464	3.51	Yes	Yes	4	9	5
322	K:K:H307	K:K:I254	6.63	No	No	0	8	9
323	K:K:I254	K:K:M308	4.37	No	No	0	9	9
324	K:K:L271	K:K:V255	4.47	No	No	0	9	9
325	K:K:C256	K:K:R516	6.96	No	Yes	1	7	9
326	K:K:S258	K:K:Y259	5.09	No	Yes	1	8	9
327	K:K:R516	K:K:S258	14.5	Yes	No	1	9	8
328	K:K:I270	K:K:Y259	7.25	Yes	Yes	1	8	9
329	K:K:T512	K:K:Y259	3.75	No	Yes	0	5	9
330	K:K:W517	K:K:Y259	8.68	Yes	Yes	1	9	9
331	K:K:E520	K:K:Y259	6.73	Yes	Yes	1	9	9
332	K:K:F261	K:K:S268	13.21	No	No	0	8	8
333	K:K:H262	K:K:L267	3.86	Yes	Yes	3	8	9
334	K:K:F509	K:K:H262	6.79	Yes	Yes	3	9	8
335	K:K:H262	K:K:P510	4.58	Yes	No	3	8	5
336	K:K:P264	K:K:T263	5.25	No	No	0	7	9
337	K:K:D265	K:K:K266	11.06	No	No	0	7	6
338	K:K:L267	K:K:Y506	12.89	Yes	Yes	3	9	9
339	K:K:F509	K:K:L267	6.09	Yes	Yes	3	9	9
340	K:K:F269	K:K:F509	7.5	Yes	Yes	3	8	9
341	K:K:?701	K:K:L271	3.42	Yes	No	0	0	9
342	K:K:D272	K:K:R516	10.72	No	Yes	0	9	9
343	K:K:L324	K:K:M274	7.07	No	No	0	9	9
344	K:K:M274	K:K:R332	9.93	No	No	0	9	9
345	K:K:E327	K:K:N275	6.57	No	No	0	9	9
346	K:K:G276	K:K:P472	4.06	No	Yes	8	9	9
347	K:K:G276	K:K:N478	3.39	No	Yes	8	9	9
348	K:K:D278	K:K:H280	3.78	No	Yes	0	9	9
349	K:K:D278	K:K:Y281	3.45	No	Yes	0	9	9
350	K:K:L279	K:K:Y297	4.69	Yes	Yes	0	9	9
351	K:K:I323	K:K:L279	5.71	No	Yes	0	9	9
352	K:K:L279	K:K:L325	4.15	Yes	No	0	9	9
353	K:K:L279	K:K:L384	5.54	Yes	No	0	9	9
354	K:K:H280	K:K:S284	5.58	Yes	No	0	9	7
355	K:K:H280	K:K:K383	5.24	Yes	Yes	0	9	9
356	K:K:H282	K:K:Y281	8.71	Yes	Yes	8	9	9
357	K:K:Q285	K:K:Y281	21.42	No	Yes	0	8	9
358	K:K:N478	K:K:Y281	3.49	Yes	Yes	8	9	9
359	K:K:H282	K:K:L325	3.86	Yes	No	8	9	9
360	K:K:H282	K:K:L470	12.86	Yes	No	8	9	8
361	K:K:H282	K:K:P472	6.1	Yes	Yes	8	9	9
362	K:K:H282	K:K:N478	3.83	Yes	Yes	8	9	9
363	K:K:F289	K:K:L283	4.87	Yes	No	0	8	8
364	K:K:F289	K:K:H286	5.66	Yes	No	0	8	8
365	K:K:H286	K:K:L470	3.86	No	No	0	8	8
366	K:K:F289	K:K:Y297	8.25	Yes	Yes	0	8	9
367	K:K:F289	K:K:L384	3.65	Yes	No	0	8	9
368	K:K:P292	K:K:S290	8.91	No	No	0	1	4
369	K:K:D293	K:K:S290	8.83	No	No	0	8	4
370	K:K:E291	K:K:S418	8.62	No	No	0	7	5
371	K:K:E291	K:K:L421	9.28	No	Yes	0	7	5
372	K:K:D293	K:K:P469	8.05	No	No	0	8	8
373	K:K:L381	K:K:M294	4.24	No	Yes	0	5	8
374	K:K:L385	K:K:M294	8.48	No	Yes	0	8	8
375	K:K:L421	K:K:M294	5.65	Yes	Yes	4	5	8
376	K:K:F452	K:K:M294	4.98	Yes	Yes	4	6	8
377	K:K:F452	K:K:I295	11.3	Yes	No	0	6	3
378	K:K:I295	K:K:L456	4.28	No	No	0	3	4
379	K:K:F296	K:K:Y297	6.19	Yes	Yes	4	9	9
380	K:K:E300	K:K:F296	11.66	Yes	Yes	4	9	9
381	K:K:F296	K:K:H330	7.92	Yes	Yes	4	9	9
382	K:K:F296	K:K:P468	7.22	Yes	No	4	9	6
383	K:K:F296	K:K:P469	11.56	Yes	No	4	9	8
384	K:K:V331	K:K:Y297	5.05	No	Yes	0	7	9
385	K:K:P469	K:K:Y297	8.34	No	Yes	4	8	9
386	K:K:A298	K:K:L381	4.73	No	No	0	8	5
387	K:K:A299	K:K:W458	3.89	No	Yes	4	7	7
388	K:K:A299	K:K:V461	3.39	No	No	4	7	7
389	K:K:E300	K:K:H330	7.39	Yes	Yes	4	9	9
390	K:K:E300	K:K:V331	7.13	Yes	No	0	9	7
391	K:K:E300	K:K:Q464	3.82	Yes	Yes	4	9	5
392	K:K:I301	K:K:I323	8.83	No	No	0	7	9
393	K:K:F453	K:K:I302	3.77	Yes	No	0	8	5
394	K:K:K448	K:K:L303	4.23	Yes	Yes	4	7	7
395	K:K:L303	K:K:W458	5.69	Yes	Yes	4	7	7
396	K:K:L303	K:K:V461	4.47	Yes	No	4	7	7
397	K:K:D373	K:K:L305	4.07	Yes	No	0	9	9
398	K:K:L305	K:K:W374	5.69	No	Yes	21	9	7
399	K:K:L305	K:K:L377	4.15	No	No	21	9	6
400	K:K:E306	K:K:N310	6.57	No	No	0	5	3
401	K:K:A444	K:K:E306	6.03	No	No	0	5	5
402	K:K:E306	K:K:K448	8.1	No	Yes	0	5	7
403	K:K:H307	K:K:R311	12.41	No	No	0	8	6
404	K:K:M308	K:K:Y315	8.38	No	Yes	0	9	9
405	K:K:H309	K:K:S370	11.16	No	No	0	9	5
406	K:K:D373	K:K:H309	11.35	Yes	No	0	9	9
407	K:K:H309	K:K:W374	8.46	No	Yes	0	9	7
408	K:K:F312	K:K:F342	5.36	No	Yes	0	3	6
409	K:K:F312	K:K:S343	6.61	No	No	0	3	7
410	K:K:F342	K:K:V314	3.93	Yes	No	0	6	8
411	K:K:D373	K:K:V314	7.3	Yes	No	0	9	8
412	K:K:D317	K:K:Y315	3.45	Yes	Yes	3	9	9
413	K:K:L318	K:K:Y315	5.86	No	Yes	0	8	9
414	K:K:N322	K:K:Y315	6.98	Yes	Yes	3	9	9
415	K:K:I333	K:K:Y315	8.46	No	Yes	0	9	9
416	K:K:D373	K:K:Y315	3.45	Yes	Yes	0	9	9
417	K:K:C340	K:K:R316	5.57	No	No	0	5	9
418	K:K:R316	K:K:V351	17	No	No	0	9	9
419	K:K:R316	K:K:Y368	9.26	No	Yes	0	9	9
420	K:K:D317	K:K:N322	6.73	Yes	Yes	3	9	9
421	K:K:D317	K:K:D335	3.99	Yes	No	3	9	9
422	K:K:D317	K:K:L338	14.93	Yes	No	0	9	9
423	K:K:K319	K:K:N322	5.6	No	Yes	3	9	9
424	K:K:K319	K:K:T353	15.02	No	No	3	9	9
425	K:K:K319	K:K:Y356	5.97	No	Yes	3	9	9
426	K:K:P320	K:K:Y356	4.17	No	Yes	3	9	9
427	K:K:M380	K:K:P320	3.35	No	No	0	7	9
428	K:K:K383	K:K:P320	6.69	Yes	No	3	9	9
429	K:K:D335	K:K:N322	5.39	No	Yes	3	9	9
430	K:K:I323	K:K:V331	4.61	No	No	0	9	7
431	K:K:L324	K:K:S334	7.51	No	No	0	9	9
432	K:K:?701	K:K:L324	10.27	Yes	No	0	0	9
433	K:K:L325	K:K:P472	3.28	No	Yes	8	9	9
434	K:K:D326	K:K:H328	3.78	No	No	0	9	3
435	K:K:D326	K:K:H330	11.35	No	Yes	0	9	9
436	K:K:E327	K:K:H328	3.69	No	No	0	9	3
437	K:K:G329	K:K:P468	4.06	No	No	0	9	6
438	K:K:H330	K:K:Q464	12.36	Yes	Yes	4	9	5
439	K:K:H330	K:K:P468	10.68	Yes	No	4	9	6
440	K:K:?701	K:K:D335	6.71	Yes	No	3	0	9
441	K:K:L338	K:K:V351	5.96	No	No	0	9	9
442	K:K:C340	K:K:P347	5.65	No	No	0	5	4
443	K:K:D341	K:K:S343	8.83	No	No	0	6	7
444	K:K:D369	K:K:F342	22.69	No	Yes	0	5	6
445	K:K:F342	K:K:S370	5.28	Yes	No	0	6	5
446	K:K:K344	K:K:S343	7.65	No	No	0	6	7
447	K:K:D369	K:K:K346	12.44	No	No	0	5	5
448	K:K:P347	K:K:Y368	6.95	No	Yes	0	4	9
449	K:K:G352	K:K:M357	3.49	No	No	0	9	9
450	K:K:T353	K:K:Y356	3.75	No	Yes	3	9	9
451	K:K:D403	K:K:H354	8.82	No	No	0	7	8
452	K:K:G355	K:K:S389	3.71	No	No	0	9	8
453	K:K:K383	K:K:Y356	8.36	Yes	Yes	3	9	9
454	K:K:S389	K:K:Y356	12.72	No	Yes	0	8	9
455	K:K:L362	K:K:M357	4.24	Yes	No	0	6	9
456	K:K:A358	K:K:E360	6.03	Yes	Yes	0	8	9
457	K:K:A358	K:K:V361	3.39	Yes	No	0	8	8
458	K:K:A358	K:K:F375	4.16	Yes	Yes	0	8	8
459	K:K:E360	K:K:P359	4.72	Yes	Yes	9	9	9
460	K:K:F375	K:K:P359	10.11	Yes	Yes	9	8	9
461	K:K:M405	K:K:P359	5.03	No	Yes	0	8	9
462	K:K:P359	K:K:R436	5.76	Yes	Yes	9	9	9
463	K:K:E360	K:K:Y368	5.61	Yes	Yes	0	9	9
464	K:K:E360	K:K:S371	4.31	Yes	Yes	9	9	8
465	K:K:E360	K:K:V433	7.13	Yes	Yes	9	9	5
466	K:K:E360	K:K:R436	8.14	Yes	Yes	9	9	9
467	K:K:V361	K:K:Y368	16.4	No	Yes	0	8	9
468	K:K:D403	K:K:L362	10.86	No	Yes	0	7	6
469	K:K:L362	K:K:M405	5.65	Yes	No	0	6	8
470	K:K:L362	K:K:T406	4.42	Yes	No	0	6	8
471	K:K:Q363	K:K:V366	5.73	No	No	0	4	5
472	K:K:S371	K:K:V433	6.46	Yes	Yes	9	8	5
473	K:K:R436	K:K:S371	5.27	Yes	Yes	9	9	8
474	K:K:C439	K:K:S371	6.89	No	Yes	9	6	8
475	K:K:L377	K:K:W374	3.42	No	Yes	21	6	7
476	K:K:G438	K:K:W374	7.04	No	Yes	0	9	7
477	K:K:C379	K:K:F375	4.19	No	Yes	0	8	8
478	K:K:F375	K:K:F391	4.29	Yes	No	0	8	9
479	K:K:F375	K:K:L429	6.09	Yes	No	0	8	9
480	K:K:F375	K:K:R436	12.83	Yes	Yes	9	8	9
481	K:K:L377	K:K:L381	6.92	No	No	0	6	5
482	K:K:G378	K:K:L428	5.13	No	No	0	9	8
483	K:K:C379	K:K:P390	7.53	No	Yes	0	8	9
484	K:K:F382	K:K:R386	9.62	Yes	Yes	4	6	5
485	K:K:F382	K:K:P390	21.67	Yes	Yes	0	6	9
486	K:K:F382	K:K:F417	5.36	Yes	Yes	4	6	7
487	K:K:F417	K:K:L385	4.87	Yes	No	0	7	8
488	K:K:L413	K:K:R386	9.72	Yes	Yes	4	7	5
489	K:K:R386	K:K:S416	7.91	Yes	No	4	5	4
490	K:K:F417	K:K:R386	4.28	Yes	Yes	4	7	5
491	K:K:H388	K:K:Q393	6.18	No	No	0	6	6
492	K:K:P390	K:K:S389	3.56	Yes	No	0	9	8
493	K:K:L429	K:K:P390	3.28	No	Yes	0	9	9
494	K:K:F391	K:K:M405	12.44	No	No	0	9	8
495	K:K:R392	K:K:T396	14.23	No	No	0	8	8
496	K:K:K397	K:K:R392	14.85	No	No	0	7	8
497	K:K:E401	K:K:K397	25.65	No	No	0	8	7
498	K:K:I402	K:K:K397	14.54	No	No	0	8	7
499	K:K:D403	K:K:H400	3.78	No	No	0	7	6
500	K:K:L407	K:K:R404	7.29	No	No	0	4	6
501	K:K:L407	K:K:T406	4.42	No	No	0	4	8
502	K:K:M409	K:K:Q430	4.08	No	No	0	4	3
503	K:K:A410	K:K:E412	4.53	No	No	0	3	4
504	K:K:A410	K:K:L429	4.73	No	No	0	3	9
505	K:K:E412	K:K:E426	15.22	No	No	0	4	3
506	K:K:L413	K:K:P414	3.28	Yes	No	0	7	7
507	K:K:F417	K:K:L413	3.65	Yes	Yes	4	7	7
508	K:K:D415	K:K:S416	4.42	No	No	0	3	4
509	K:K:F417	K:K:S416	10.57	Yes	No	4	7	4
510	K:K:F417	K:K:L421	6.09	Yes	Yes	4	7	5
511	K:K:P419	K:K:S418	3.56	No	No	20	3	5
512	K:K:E420	K:K:S418	4.31	No	No	20	4	5
513	K:K:E420	K:K:P419	4.72	No	No	20	4	3
514	K:K:P419	K:K:R422	5.76	No	No	0	3	4
515	K:K:E420	K:K:R454	11.63	No	No	0	4	1
516	K:K:F452	K:K:L421	10.96	Yes	Yes	4	6	5
517	K:K:E426	K:K:R422	3.49	No	No	0	3	4
518	K:K:L424	K:K:L428	4.15	Yes	No	0	5	8
519	K:K:L424	K:K:S450	4.5	Yes	No	0	5	7
520	K:K:F452	K:K:L424	6.09	Yes	Yes	4	6	5
521	K:K:F453	K:K:L424	3.65	Yes	Yes	4	8	5
522	K:K:G427	K:K:L437	3.42	No	No	0	3	7
523	K:K:Q430	K:K:R435	14.02	No	No	0	3	3
524	K:K:Q430	K:K:R436	3.5	No	Yes	0	3	9
525	K:K:D432	K:K:N434	4.04	No	No	0	4	1
526	K:K:D432	K:K:R435	3.57	No	No	0	4	3
527	K:K:R436	K:K:V433	5.23	Yes	Yes	9	9	5
528	K:K:C439	K:K:V433	3.42	No	Yes	9	6	5
529	K:K:C439	K:K:R436	9.75	No	Yes	9	6	9
530	K:K:L437	K:K:V447	4.47	No	No	0	7	5
531	K:K:E446	K:K:G441	4.91	No	No	0	5	3
532	K:K:Q445	K:K:R442	11.68	No	No	0	1	1
533	K:K:E446	K:K:R442	3.49	No	No	0	5	1
534	K:K:K448	K:K:Q445	6.78	Yes	No	4	7	1
535	K:K:E449	K:K:Q445	7.65	No	No	4	2	1
536	K:K:E449	K:K:K448	4.05	No	Yes	4	2	7
537	K:K:K448	K:K:W458	15.08	Yes	Yes	4	7	7
538	K:K:P451	K:K:S450	5.34	No	No	0	1	7
539	K:K:F452	K:K:F453	10.72	Yes	Yes	4	6	8
540	K:K:F453	K:K:W458	10.02	Yes	Yes	4	8	7
541	K:K:L456	K:K:Y466	9.38	No	Yes	0	4	3
542	K:K:V461	K:K:W458	4.9	No	Yes	4	7	7
543	K:K:L463	K:K:Q459	6.65	No	No	0	5	4
544	K:K:K465	K:K:M460	4.32	No	No	0	4	5
545	K:K:M460	K:K:Y466	11.97	No	Yes	0	5	3
546	K:K:K465	K:K:L463	7.05	No	No	0	4	5
547	K:K:P467	K:K:Y466	4.17	No	Yes	0	1	3
548	K:K:L470	K:K:P472	3.28	No	Yes	8	8	9
549	K:K:I471	K:K:P472	3.39	No	Yes	0	3	9
550	K:K:N478	K:K:P472	4.89	Yes	Yes	8	9	9
551	K:K:N478	K:K:P473	6.52	Yes	No	0	9	9
552	K:K:D481	K:K:D484	7.98	No	No	0	9	9
553	K:K:F483	R:R:N370	6.04	No	No	0	7	7
554	K:K:D489	K:K:E491	5.2	No	No	0	9	7
555	K:K:D489	K:K:D492	5.32	No	No	0	9	8
556	K:K:E490	K:K:E491	3.81	No	No	0	7	7
557	K:K:L498	K:K:Q503	6.65	No	No	0	7	4
558	K:K:D502	K:K:L499	8.14	No	No	0	9	6
559	K:K:E504	K:K:R507	16.28	No	No	0	4	4
560	K:K:L505	K:K:Y506	3.52	No	Yes	3	8	9
561	K:K:N508	K:K:R507	8.44	No	No	0	6	4
562	K:K:F509	K:K:P510	4.33	Yes	No	3	9	5
563	K:K:E515	K:K:I513	5.47	No	No	0	8	7
564	K:K:I513	K:K:R516	5.01	No	Yes	1	7	9
565	K:K:Q518	K:K:S514	4.33	Yes	No	1	9	7
566	K:K:Q518	K:K:W517	3.29	Yes	Yes	1	9	9
567	K:K:V521	K:K:W517	8.58	No	Yes	0	8	9
568	K:K:E523	K:K:Q519	11.47	No	No	0	8	4
569	K:K:T524	K:K:V525	7.93	No	No	0	8	7
570	K:K:F526	K:K:N530	10.87	Yes	No	1	8	9
571	K:K:E537	K:K:T533	8.47	No	No	1	7	5
572	K:K:E550	K:K:N544	7.89	No	No	0	3	4
573	K:K:E595	K:K:H549	12.31	No	No	0	3	2
574	K:K:E550	K:K:Y553	3.37	No	No	0	3	5
575	K:K:C559	K:K:L555	9.52	No	Yes	6	6	4
576	K:K:H562	K:K:L555	19.28	Yes	Yes	6	7	4
577	K:K:L555	K:K:Y582	3.52	Yes	Yes	6	4	5
578	K:K:D558	K:K:P585	6.44	No	No	0	9	9
579	K:K:C559	K:K:H562	4.42	No	Yes	6	6	7
580	K:K:C559	K:K:F584	4.19	No	No	6	6	7
581	K:K:I560	K:K:L583	7.14	No	No	0	7	9
582	K:K:I560	K:K:P585	6.77	No	No	0	7	9
583	K:K:M561	K:K:W643	8.14	Yes	No	0	4	9
584	K:K:E646	K:K:M561	4.06	No	Yes	7	8	4
585	K:K:H562	K:K:Y580	10.89	Yes	Yes	6	7	8
586	K:K:H562	K:K:Y582	6.53	Yes	Yes	6	7	5
587	K:K:G563	K:K:Y580	4.35	No	Yes	0	9	8
588	K:K:R578	K:K:Y564	13.38	No	No	0	6	4
589	K:K:Y564	K:K:Y580	13.9	No	Yes	0	4	8
590	K:K:F581	K:K:M565	12.44	Yes	Yes	0	6	5
591	K:K:L632	K:K:M565	4.24	No	Yes	0	6	5
592	K:K:M565	K:K:W643	20.94	Yes	No	0	5	9
593	K:K:R578	K:K:S566	3.95	No	No	0	6	5
594	K:K:Q633	K:K:S566	7.22	Yes	No	0	7	5
595	K:K:K567	K:K:N570	5.6	No	No	0	8	7
596	K:K:K567	K:K:Q577	4.07	No	Yes	0	8	8
597	K:K:M568	K:K:W576	16.29	No	Yes	0	7	8
598	K:K:L573	K:K:N570	5.49	No	No	0	5	7
599	K:K:Q575	K:K:W576	3.29	No	Yes	0	4	8
600	K:K:K615	K:K:W576	4.64	No	Yes	0	9	8
601	K:K:Q633	K:K:W576	7.67	Yes	Yes	0	7	8
602	K:K:Q577	K:K:R579	12.85	Yes	No	13	8	6
603	K:K:Q577	K:K:W590	3.29	Yes	Yes	13	8	5
604	K:K:D635	K:K:R578	9.53	No	No	0	4	6
605	K:K:R579	K:K:W590	14.99	No	Yes	13	6	5
606	K:K:G592	K:K:R579	6	No	No	0	2	6
607	K:K:Y580	K:K:Y582	9.93	Yes	Yes	6	8	5
608	K:K:R591	K:K:Y580	11.32	Yes	Yes	6	5	8
609	K:K:F581	K:K:L588	3.65	Yes	No	0	6	6
610	K:K:F581	K:K:W590	11.02	Yes	Yes	13	6	5
611	K:K:F581	K:K:L600	3.65	Yes	No	13	6	6
612	K:K:R591	K:K:Y582	7.2	Yes	Yes	6	5	5
613	K:K:L583	K:K:L588	4.15	No	No	0	9	6
614	K:K:L583	K:K:W643	3.42	No	No	0	9	9
615	K:K:F584	K:K:R587	10.69	No	No	6	7	9
616	K:K:E589	K:K:F584	11.66	No	No	6	9	7
617	K:K:N586	K:K:R587	15.67	No	No	0	9	9
618	K:K:E589	K:K:R587	15.12	No	No	6	9	9
619	K:K:L600	K:K:W590	10.25	No	Yes	13	6	5
620	K:K:G594	K:K:R591	7.51	No	Yes	0	5	5
621	K:K:P597	K:K:R591	10.09	No	Yes	0	4	5
622	K:K:F630	K:K:L600	3.65	No	No	0	3	6
623	K:K:E605	K:K:L601	3.98	No	Yes	10	4	4
624	K:K:I606	K:K:L601	7.14	Yes	Yes	10	4	4
625	K:K:I624	K:K:L601	4.28	Yes	Yes	10	3	4
626	K:K:E605	K:K:T602	9.88	No	No	0	4	4
627	K:K:E604	K:K:R625	8.14	No	No	0	6	4
628	K:K:E605	K:K:I624	5.47	No	Yes	10	4	3
629	K:K:I606	K:K:L622	4.28	Yes	No	0	4	2
630	K:K:I606	K:K:I624	4.42	Yes	Yes	10	4	3
631	K:K:I606	K:K:Y651	12.09	Yes	Yes	10	4	5
632	K:K:K623	K:K:S608	4.59	No	No	0	3	4
633	K:K:L622	K:K:V609	4.47	No	No	0	2	4
634	K:K:V609	K:K:Y651	5.05	No	Yes	0	4	5
635	K:K:E611	K:K:K618	4.05	No	No	0	4	5
636	K:K:E611	K:K:K644	4.05	No	No	0	4	3
637	K:K:L621	K:K:T612	7.37	No	No	0	4	4
638	K:K:K618	K:K:Q613	10.85	No	No	0	5	1
639	K:K:I614	K:K:K615	4.36	No	No	0	2	9
640	K:K:Q633	K:K:R617	8.18	Yes	No	0	7	6
641	K:K:C619	K:K:Q633	4.58	No	Yes	0	4	7
642	K:K:L620	K:K:L622	4.15	No	No	0	7	2
643	K:K:L620	K:K:L640	4.15	No	No	0	7	5
644	K:K:K644	K:K:L620	5.64	No	No	0	3	7
645	K:K:K623	K:K:L621	4.23	No	No	0	3	4
646	K:K:L621	K:K:Q629	3.99	No	No	0	4	4
647	K:K:C634	K:K:L640	6.35	No	No	0	6	5
648	K:K:D635	K:K:E639	7.8	No	Yes	0	4	6
649	K:K:E639	K:K:S636	7.19	Yes	No	1	6	7
650	K:K:D637	K:K:P638	4.83	No	Yes	0	5	8
651	K:K:E646	K:K:Q642	7.65	No	Yes	7	8	8
652	K:K:K644	K:K:R648	11.14	No	Yes	0	3	4
653	K:K:D649	K:K:K645	5.53	No	No	0	2	4
654	K:K:R648	K:K:Y651	6.17	Yes	Yes	10	4	5
655	K:K:R648	K:K:R652	15.99	Yes	No	10	4	3
656	K:K:R652	K:K:Y651	6.17	No	Yes	10	3	5
657	K:K:Q655	K:K:Y651	3.38	No	Yes	0	4	5
658	K:K:E653	K:K:L657	5.3	No	No	0	1	4
659	L:L:R8	R:R:E53	4.65	No	Yes	2	0	2
660	L:L:R8	R:R:R212	5.33	No	No	0	0	1
661	L:L:R8	R:R:Y339	11.32	No	No	2	0	2
662	L:L:P10	L:L:R9	4.32	Yes	No	0	0	0
663	L:L:R9	R:R:F326	6.41	No	Yes	0	0	4
664	L:L:P10	R:R:W334	16.21	Yes	No	2	0	4
665	L:L:P10	R:R:Y339	6.95	Yes	No	2	0	2
666	L:L:P10	R:R:Y342	11.13	Yes	Yes	2	0	4
667	L:L:I12	L:L:Y11	3.63	Yes	Yes	0	0	0
668	L:L:Y11	R:R:E53	5.61	Yes	Yes	0	0	2
669	L:L:Y11	R:R:V223	8.83	Yes	No	0	0	4
670	L:L:Y11	R:R:T225	3.75	Yes	No	0	0	4
671	L:L:I12	R:R:F127	5.02	Yes	Yes	2	0	4
672	L:L:I12	R:R:H131	11.93	Yes	No	2	0	3
673	L:L:I12	R:R:Y342	6.04	Yes	Yes	2	0	4
674	L:L:I12	R:R:H343	6.63	Yes	Yes	2	0	4
675	L:L:I12	R:R:Y346	10.88	Yes	Yes	2	0	4
676	L:L:L13	R:R:Y145	15.24	Yes	Yes	2	0	4
677	L:L:L13	R:R:F205	7.31	Yes	Yes	2	0	4
678	L:L:L13	R:R:P226	6.57	Yes	Yes	2	0	5
679	L:L:L13	R:R:F326	3.65	Yes	Yes	2	0	4
680	L:L:L13	R:R:Y346	4.69	Yes	Yes	2	0	4
681	R:R:E53	R:R:N57	7.89	Yes	No	0	2	2
682	R:R:E53	R:R:Y339	6.73	Yes	No	2	2	2
683	R:R:H132	R:R:L54	5.14	Yes	No	0	4	5
684	R:R:L54	R:R:S213	6.01	No	No	0	5	1
685	R:R:T58	R:R:V56	7.93	Yes	Yes	2	1	2
686	R:R:H131	R:R:V56	11.07	No	Yes	2	3	2
687	R:R:H343	R:R:V56	4.15	Yes	Yes	2	4	2
688	R:R:D340	R:R:N57	6.73	No	No	0	1	2
689	R:R:K63	R:R:T58	4.5	No	Yes	0	5	1
690	R:R:T58	R:R:Y344	6.24	Yes	Yes	2	1	1
691	R:R:M347	R:R:T58	4.52	No	Yes	2	3	1
692	R:R:D59	R:R:Y61	5.75	No	No	0	3	2
693	R:R:S62	R:R:Y344	7.63	No	Yes	0	3	1
694	R:R:K63	R:R:W129	9.28	No	No	0	5	5
695	R:R:M347	R:R:V66	9.13	No	No	0	3	5
696	R:R:I128	R:R:T67	4.56	No	No	0	4	6
697	R:R:T67	R:R:W129	3.64	No	No	0	6	5
698	R:R:M120	R:R:Y70	8.38	Yes	Yes	2	8	7
699	R:R:E123	R:R:Y70	6.73	Yes	Yes	2	6	7
700	R:R:N350	R:R:Y70	4.65	Yes	Yes	2	6	7
701	R:R:Y354	R:R:Y70	7.94	Yes	Yes	2	7	7
702	R:R:L73	R:R:V355	5.96	No	No	0	7	5
703	R:R:L73	R:R:T358	8.84	No	No	0	7	7
704	R:R:F74	R:R:T78	6.49	Yes	No	0	7	6
705	R:R:F74	R:R:L116	6.09	Yes	No	0	7	7
706	R:R:F74	R:R:L117	4.87	Yes	No	0	7	5
707	R:R:F74	R:R:M120	6.22	Yes	Yes	0	7	8
708	R:R:G77	R:R:V76	3.68	No	No	0	8	6
709	R:R:G80	R:R:V79	3.68	No	No	0	9	5
710	R:R:D112	R:R:N81	12.12	No	No	0	9	9
711	R:R:L113	R:R:N81	6.87	No	No	0	7	9
712	R:R:L113	R:R:T82	4.42	No	No	0	7	4
713	R:R:F375	R:R:V83	7.87	Yes	No	0	7	6
714	R:R:F371	R:R:T84	3.89	Yes	No	0	8	9
715	R:R:F371	R:R:T87	3.89	Yes	No	0	8	7
716	R:R:H102	R:R:L88	10.29	No	No	0	8	7
717	R:R:M180	R:R:T100	4.52	No	No	0	7	7
718	R:R:T100	R:R:T185	14.13	No	No	0	7	7
719	R:R:E165	R:R:V101	5.7	Yes	No	0	8	8
720	R:R:K186	R:R:Y103	4.78	No	No	0	3	5
721	R:R:H104	R:R:S161	8.37	No	No	0	8	7
722	R:R:E165	R:R:H104	11.08	Yes	No	0	8	8
723	R:R:L105	R:R:L162	4.15	No	No	11	8	9
724	R:R:L105	R:R:Y364	10.55	No	No	11	8	9
725	R:R:L105	W:W:?1	6.62	No	Yes	11	8	0
726	R:R:N158	R:R:S107	8.94	No	No	0	8	9
727	R:R:I189	R:R:S107	6.19	No	No	0	7	9
728	R:R:L108	R:R:N158	6.87	Yes	No	0	9	8
729	R:R:L108	R:R:V159	4.47	Yes	No	0	9	8
730	R:R:L108	R:R:N360	6.87	Yes	No	11	9	9
731	R:R:L108	R:R:Y364	3.52	Yes	No	11	9	9
732	R:R:S111	R:R:T155	4.8	No	No	0	8	9
733	R:R:D112	R:R:S357	10.31	No	No	0	9	9
734	R:R:D112	R:R:N360	6.73	No	No	0	9	9
735	R:R:L114	R:R:W193	4.56	No	No	0	8	9
736	R:R:C151	R:R:T115	5.07	No	Yes	0	7	7
737	R:R:F353	R:R:T115	3.89	Yes	Yes	0	7	7
738	R:R:S357	R:R:T115	6.4	No	Yes	0	9	7
739	R:R:L116	R:R:Y354	4.69	No	Yes	0	7	7
740	R:R:L118	R:R:L147	15.22	No	No	0	5	5
741	R:R:A119	R:R:R148	4.15	No	Yes	2	7	7
742	R:R:A119	R:R:Y354	4	No	Yes	2	7	7
743	R:R:M120	R:R:Y354	8.38	Yes	Yes	2	8	7
744	R:R:V122	R:R:Y144	12.62	No	Yes	0	6	6
745	R:R:E123	R:R:F127	3.5	Yes	Yes	2	6	4
746	R:R:E123	R:R:Y144	3.37	Yes	Yes	2	6	6
747	R:R:E123	R:R:R148	6.98	Yes	Yes	2	6	7
748	R:R:E123	R:R:N350	7.89	Yes	Yes	2	6	6
749	R:R:E123	R:R:Y354	11.22	Yes	Yes	2	6	7
750	R:R:I128	R:R:L124	7.14	No	No	0	4	6
751	R:R:W129	R:R:Y125	23.15	No	No	0	5	5
752	R:R:N126	R:R:W134	6.78	No	Yes	0	5	8
753	R:R:F127	R:R:Y144	5.16	Yes	Yes	2	4	6
754	R:R:F127	R:R:Y145	5.16	Yes	Yes	2	4	4
755	R:R:F127	R:R:Y346	8.25	Yes	Yes	2	4	4
756	R:R:P133	R:R:V130	5.3	Yes	No	0	5	5
757	R:R:H131	R:R:H343	15.53	No	Yes	2	3	4
758	R:R:H132	R:R:P133	6.1	Yes	Yes	14	4	5
759	R:R:D215	R:R:H132	3.78	No	Yes	14	2	4
760	R:R:H132	R:R:H218	4.78	Yes	No	14	4	3
761	R:R:G220	R:R:H132	9.53	No	Yes	14	5	4
762	R:R:G220	R:R:P133	4.06	No	Yes	14	5	5
763	R:R:F136	R:R:W134	4.01	No	Yes	0	7	8
764	R:R:C141	R:R:W134	9.14	No	Yes	15	9	8
765	R:R:E209	R:R:W134	7.63	Yes	Yes	15	5	8
766	R:R:C224	R:R:W134	10.45	Yes	Yes	15	9	8
767	R:R:F136	R:R:G140	4.52	No	No	0	7	6
768	R:R:D138	R:R:R142	9.53	No	No	0	3	7
769	R:R:D138	R:R:E209	7.8	No	Yes	0	3	5
770	R:R:A139	R:R:R142	4.15	No	No	0	1	7
771	R:R:C141	R:R:C224	7.28	No	Yes	15	9	9
772	R:R:Y144	R:R:Y145	5.96	Yes	Yes	2	6	4
773	R:R:R148	R:R:Y144	12.35	Yes	Yes	2	7	6
774	R:R:F205	R:R:Y145	12.38	Yes	Yes	2	4	4
775	R:R:F146	R:R:L147	4.87	No	No	0	6	5
776	R:R:F146	R:R:L198	6.09	No	No	0	6	4
777	R:R:F146	R:R:V201	11.8	No	Yes	0	6	5
778	R:R:R148	R:R:Y354	6.17	Yes	Yes	2	7	7
779	R:R:D149	R:R:V201	7.3	Yes	Yes	0	5	5
780	R:R:D149	R:R:L204	9.5	Yes	Yes	16	5	5
781	R:R:D149	R:R:N240	12.12	Yes	Yes	16	5	6
782	R:R:D149	R:R:R323	5.96	Yes	No	16	5	6
783	R:R:A150	R:R:V201	3.39	No	Yes	0	6	5
784	R:R:T152	R:R:W316	7.28	No	Yes	2	7	8
785	R:R:F353	R:R:T152	3.89	Yes	No	2	7	7
786	R:R:L157	R:R:Y153	15.24	Yes	No	0	6	7
787	R:R:M243	R:R:Y153	20.35	No	No	0	5	7
788	R:R:A154	R:R:W193	3.89	No	No	0	7	9
789	R:R:A156	R:R:P248	3.74	No	No	0	8	9
790	R:R:I192	R:R:L157	7.14	No	Yes	0	7	6
791	R:R:I252	R:R:V159	4.61	No	No	0	8	8
792	R:R:V159	W:W:?1	4.07	No	Yes	0	8	0
793	R:R:L162	W:W:?1	9.46	No	Yes	11	9	0
794	R:R:L255	R:R:S163	7.51	No	No	0	7	9
795	R:R:N256	R:R:S163	4.47	No	No	0	9	9
796	R:R:L255	R:R:V164	4.47	No	No	0	7	7
797	R:R:A169	R:R:E165	4.53	No	Yes	0	8	8
798	R:R:E165	R:R:M180	13.53	Yes	No	0	8	7
799	R:R:R166	W:W:?1	27.39	No	Yes	0	9	0
800	R:R:C171	R:R:Y167	4.03	No	Yes	0	7	8
801	R:R:L255	R:R:Y167	9.38	No	Yes	0	7	8
802	R:R:I259	R:R:Y167	7.25	No	Yes	0	9	8
803	R:R:A176	R:R:L168	4.73	No	No	0	6	4
804	R:R:L168	R:R:L179	4.15	No	No	0	4	4
805	R:R:I170	R:R:I259	5.89	No	No	0	9	9
806	R:R:H172	R:R:K175	13.1	No	No	0	6	4
807	R:R:F188	R:R:R184	9.62	No	No	0	6	5
808	R:R:F188	R:R:K187	8.69	No	No	0	6	4
809	R:R:P202	R:R:V201	5.3	No	Yes	0	7	5
810	R:R:L204	R:R:M203	4.24	Yes	No	0	5	5
811	R:R:L204	R:R:V236	4.47	Yes	No	0	5	6
812	R:R:L204	R:R:N240	12.36	Yes	Yes	16	5	6
813	R:R:F205	R:R:M207	13.68	Yes	Yes	0	4	6
814	R:R:F205	R:R:P226	8.67	Yes	Yes	2	4	5
815	R:R:I228	R:R:M207	10.2	No	Yes	0	5	6
816	R:R:C224	R:R:E209	7.6	Yes	Yes	15	9	5
817	R:R:Q210	R:R:R212	5.84	No	No	0	1	1
818	R:R:Q210	R:R:T225	5.67	No	No	0	1	4
819	R:R:G216	R:R:N211	3.39	No	No	0	2	2
820	R:R:L222	R:R:N211	9.61	No	No	0	4	2
821	R:R:G221	R:R:S213	3.71	No	No	0	2	1
822	R:R:D215	R:R:H218	13.87	No	No	14	2	3
823	R:R:D215	R:R:G221	3.35	No	No	0	2	2
824	R:R:G220	R:R:H218	4.77	No	No	14	5	3
825	R:R:P226	R:R:T225	5.25	Yes	No	0	5	4
826	R:R:P226	R:R:V233	3.53	Yes	No	0	5	5
827	R:R:F326	R:R:P226	4.33	Yes	Yes	2	4	5
828	R:R:I228	R:R:T232	12.16	No	No	0	5	4
829	R:R:I228	R:R:V233	12.29	No	No	0	5	5
830	R:R:H229	R:R:T230	5.48	No	No	0	4	4
831	R:R:C327	R:R:V233	3.42	No	No	0	3	5
832	R:R:K234	R:R:Y328	7.17	No	No	0	4	5
833	R:R:Q238	R:R:T241	4.25	No	No	0	5	6
834	R:R:F242	R:R:Q238	5.86	No	No	0	5	5
835	R:R:M243	R:R:N240	5.61	No	Yes	0	5	6
836	R:R:N240	R:R:R323	7.23	Yes	No	16	6	6
837	R:R:L324	R:R:T241	4.42	No	No	0	6	6
838	R:R:F242	R:R:I246	8.79	No	No	0	5	5
839	R:R:M243	R:R:S244	4.6	No	No	0	5	6
840	R:R:H320	R:R:S244	5.58	No	No	0	7	6
841	R:R:F245	R:R:F312	4.29	No	No	0	8	9
842	R:R:F245	R:R:L317	4.87	No	No	0	8	7
843	R:R:F245	R:R:H320	11.31	No	No	0	8	7
844	R:R:F247	R:R:P248	4.33	No	No	0	6	9
845	R:R:F247	R:R:V251	3.93	No	No	0	6	6
846	R:R:F312	R:R:M249	7.46	No	No	0	9	6
847	R:R:I252	R:R:N256	4.25	No	No	0	8	9
848	R:R:L305	R:R:N256	5.49	No	No	0	8	9
849	R:R:L263	R:R:L298	4.15	No	No	0	8	7
850	R:R:L298	R:R:V267	4.47	No	No	0	7	6
851	R:R:R299	R:R:V267	5.23	No	No	0	5	6
852	R:R:Q269	R:R:R268	5.84	No	No	0	7	4
853	R:R:E291	R:R:R294	3.49	No	No	0	4	4
854	R:R:R299	R:R:V295	3.92	No	No	0	5	3
855	R:R:H300	R:R:Q296	8.65	No	No	0	8	5
856	R:R:V304	R:R:V367	8.02	No	No	0	8	7
857	R:R:L305	W:W:?1	4.73	No	Yes	0	8	0
858	R:R:V308	W:W:?1	19.34	No	Yes	0	8	0
859	R:R:F312	R:R:W316	19.04	No	Yes	0	9	8
860	R:R:C315	R:R:S356	6.89	No	No	0	9	9
861	R:R:F353	R:R:W316	7.02	Yes	Yes	2	7	8
862	R:R:S356	R:R:W316	7.41	No	Yes	0	9	8
863	R:R:L317	R:R:P318	4.93	No	No	0	7	9
864	R:R:L352	R:R:P318	3.28	No	No	0	7	9
865	R:R:R322	R:R:Y319	6.17	Yes	No	0	5	6
866	R:R:R323	R:R:Y319	7.2	No	No	0	6	6
867	R:R:F353	R:R:Y319	6.19	Yes	No	0	7	6
868	R:R:R322	R:R:Y342	6.17	Yes	Yes	2	5	4
869	R:R:F345	R:R:R322	4.28	No	Yes	2	4	5
870	R:R:R322	R:R:Y346	11.32	Yes	Yes	2	5	4
871	R:R:R322	R:R:T349	7.76	Yes	No	2	5	6
872	R:R:N350	R:R:R322	3.62	Yes	Yes	2	6	5
873	R:R:C327	R:R:F326	4.19	No	Yes	0	3	4
874	R:R:I329	R:R:W334	4.7	No	No	0	3	4
875	R:R:D331	R:R:S330	4.42	No	No	0	1	2
876	R:R:W334	R:R:Y342	3.86	No	Yes	2	4	4
877	R:R:P336	R:R:T335	5.25	No	No	0	4	4
878	R:R:D340	R:R:Y344	4.6	No	Yes	0	1	1
879	R:R:H343	R:R:Y342	5.44	Yes	Yes	2	4	4
880	R:R:M347	R:R:Y344	4.79	No	Yes	2	3	1
881	R:R:F345	R:R:T349	7.78	No	No	2	4	6
882	R:R:N350	R:R:Y346	9.3	Yes	Yes	2	6	4
883	R:R:N350	R:R:Y354	3.49	Yes	Yes	2	6	7
884	R:R:F353	R:R:Y354	14.44	Yes	Yes	2	7	7
885	R:R:I359	R:R:L363	4.28	No	No	0	6	8
886	R:R:N360	R:R:Y364	3.49	No	No	11	9	9
887	R:R:N365	R:R:R372	10.85	No	No	0	7	9
888	R:R:F375	R:R:N365	13.29	Yes	No	0	7	7
889	R:R:V367	W:W:?1	5.09	No	Yes	0	7	0
890	R:R:S368	W:W:?1	5.13	No	Yes	0	8	0
891	R:R:F371	R:R:F375	5.36	Yes	Yes	0	8	7
892	R:R:F371	W:W:?1	5.83	Yes	Yes	0	8	0
893	R:R:F375	R:R:L376	3.65	Yes	No	0	7	4
894	K:K:E446	K:K:G443	3.27	No	No	0	5	4
895	K:K:A236	K:K:I227	3.25	No	No	0	9	8
896	K:K:A480	K:K:I485	3.25	No	No	0	9	9
897	R:R:A160	R:R:I252	3.25	No	No	0	8	8
898	K:K:C634	K:K:M565	3.24	No	Yes	0	6	5
899	R:R:C171	R:R:K262	3.23	No	No	0	7	5
900	R:R:S213	R:R:V223	3.23	No	No	0	1	4
901	R:R:C327	R:R:K234	3.23	No	No	0	3	4
902	K:K:A260	K:K:M257	3.22	No	No	0	8	9
903	R:R:A176	R:R:M180	3.22	No	No	0	6	7
904	K:K:A522	K:K:K62	3.21	No	No	0	6	5
905	R:R:V75	R:R:V76	3.21	No	No	0	5	6
906	K:K:G548	K:K:H549	3.18	No	No	0	2	2
907	K:K:?701	K:K:G277	3.17	Yes	No	0	0	9
908	R:R:T358	R:R:V76	3.17	No	No	0	7	6
909	R:R:C151	R:R:L114	3.17	No	No	0	7	8
910	R:R:T378	R:R:T87	3.14	No	No	0	5	7
911	R:R:T115	R:R:T155	3.14	Yes	No	0	7	9
912	R:R:A109	R:R:N81	3.13	No	No	0	9	9
913	R:R:A135	R:R:N126	3.13	No	No	0	3	5
914	K:K:I302	K:K:V447	3.07	No	No	0	5	5
915	K:K:I614	K:K:V631	3.07	No	No	0	2	4
916	R:R:I237	R:R:V236	3.07	No	No	0	6	6
917	R:R:M249	R:R:S253	3.07	No	No	0	6	5
918	R:R:H172	R:R:P173	3.05	No	No	0	6	8
919	K:K:I614	K:K:T612	3.04	No	No	0	2	4
920	R:R:I374	R:R:T87	3.04	No	No	0	6	7
921	R:R:M249	R:R:V313	3.04	No	No	0	6	7
922	K:K:F174	K:K:G64	3.01	Yes	No	0	7	8
923	R:R:M207	R:R:T227	3.01	Yes	No	0	6	3
924	K:K:G200	K:K:R199	3	No	Yes	0	9	9
925	K:K:G486	K:K:R199	3	No	Yes	0	7	9
926	K:K:L318	K:K:S376	3	No	No	0	8	8
927	R:R:G143	R:R:R142	3	No	No	0	5	7
928	R:R:L157	R:R:S196	3	Yes	No	0	6	8
929	K:K:L14	K:K:V477	2.98	No	Yes	0	8	8
930	K:K:L34	K:K:V180	2.98	Yes	No	0	8	7
931	K:K:L245	K:K:V313	2.98	No	Yes	0	8	8
932	K:K:L413	K:K:V411	2.98	Yes	No	0	7	7
933	R:R:N158	R:R:S161	2.98	No	No	0	8	7
934	R:R:L317	R:R:V321	2.98	No	No	0	7	5
935	R:R:L352	R:R:V348	2.98	No	No	0	7	6
936	K:K:I32	K:K:I529	2.94	No	Yes	0	6	5
937	K:K:N189	K:K:T187	2.92	No	No	0	7	7
938	R:R:D55	R:R:V56	2.92	No	Yes	0	3	2
939	K:K:I129	K:K:K126	2.91	Yes	No	0	2	1
940	K:K:I624	K:K:K628	2.91	Yes	No	0	3	3
941	K:K:G207	K:K:Y13	2.9	No	Yes	0	9	9
942	K:K:F462	K:K:P252	2.89	No	Yes	0	6	7
943	K:K:P359	K:K:R431	2.88	Yes	No	0	9	8
944	K:K:E116	K:K:S121	2.87	No	No	0	4	4
945	K:K:E204	K:K:S487	2.87	Yes	No	0	9	8
946	K:K:K541	K:K:K545	2.87	No	No	0	4	5
947	R:R:Q269	R:R:V265	2.87	No	No	0	7	4
948	K:K:E48	K:K:V53	2.85	No	No	0	4	2
949	R:R:I237	R:R:L324	2.85	No	No	0	6	6
950	R:R:I362	R:R:L363	2.85	No	No	0	6	8
951	K:K:L118	K:K:M114	2.83	No	No	0	3	4
952	K:K:L601	K:K:M603	2.83	Yes	Yes	0	4	7
953	K:K:L647	K:K:M603	2.83	No	Yes	0	6	7
954	K:K:E56	K:K:T54	2.82	No	No	0	3	4
955	K:K:K164	K:K:L76	2.82	No	Yes	0	3	2
956	K:K:E100	K:K:T97	2.82	No	No	0	4	2
957	K:K:E532	K:K:T528	2.82	No	No	0	4	5
958	K:K:E604	K:K:T602	2.82	No	No	0	6	4
959	R:R:K175	R:R:L168	2.82	No	No	0	4	4
960	R:R:D59	R:R:I60	2.8	No	No	0	3	2
961	K:K:H194	K:K:S12	2.79	Yes	No	0	9	9
962	K:K:L157	K:K:L82	2.77	No	No	0	8	4
963	K:K:D110	K:K:M114	2.77	No	No	0	3	4
964	K:K:D160	K:K:K164	2.77	No	No	0	1	3
965	K:K:A211	R:R:F174	2.77	No	Yes	0	8	7
966	K:K:D552	K:K:L555	2.71	No	Yes	0	5	4
967	R:R:A351	R:R:Y70	2.67	No	Yes	0	5	7
968	R:R:A200	R:R:Y153	2.67	No	No	0	7	7
969	K:K:H394	K:K:K399	2.62	No	No	0	7	8
970	K:K:H400	K:K:K399	2.62	No	No	0	6	8
971	K:K:F391	K:K:T408	2.59	No	No	0	9	6
972	R:R:H300	R:R:L366	2.57	No	No	0	8	6
973	K:K:E233	K:K:Q231	2.55	No	No	0	9	7
974	K:K:V641	K:K:Y46	2.52	No	Yes	0	4	4
975	K:K:I241	K:K:R240	2.51	No	Yes	0	5	9
976	R:R:V122	R:R:W134	2.45	No	Yes	0	6	8
977	K:K:F202	K:K:L235	2.44	Yes	No	0	9	9
978	K:K:F382	K:K:L425	2.44	Yes	No	4	6	8
979	K:K:F417	K:K:L425	2.44	Yes	No	4	7	8
980	R:R:F247	R:R:L157	2.44	No	Yes	0	6	6
981	R:R:I258	R:R:Y167	2.42	No	Yes	0	5	8
982	K:K:D527	K:K:F526	2.39	No	Yes	0	3	8
983	R:R:M325	R:R:Y342	2.39	No	Yes	0	4	4
984	K:K:D492	K:K:R226	2.38	No	Yes	0	8	9
985	K:K:L237	K:K:Y506	2.34	No	Yes	0	9	9
986	K:K:E532	K:K:R535	2.33	No	No	0	4	5
987	K:K:D457	K:K:Y466	2.3	No	Yes	0	7	3
988	R:R:L110	R:R:W193	2.28	No	No	0	6	9
989	K:K:F382	K:K:H388	2.26	Yes	No	4	6	6
990	K:K:H388	K:K:R386	2.26	No	Yes	4	6	5
991	R:R:F174	R:R:H172	2.26	Yes	No	0	7	6
992	K:K:G200	K:K:G201	2.11	No	No	0	9	9
993	K:K:G626	K:K:G627	2.11	No	No	0	3	2
994	R:R:G293	R:R:P292	2.03	No	No	0	3	3
995	R:R:C141	R:R:G208	1.96	No	No	15	9	4
996	R:R:C224	R:R:G208	1.96	Yes	No	15	9	4
997	K:K:?701	K:K:A479	1.95	Yes	No	0	0	9
998	R:R:A109	R:R:G106	1.95	No	No	0	9	6
999	K:K:A596	K:K:P597	1.87	No	No	0	4	4
1000	R:R:A219	R:R:P133	1.87	No	Yes	0	1	5
1001	K:K:G134	K:K:V137	1.84	No	No	0	1	1
1002	K:K:G387	K:K:V288	1.84	No	No	0	8	5
1003	R:R:G80	R:R:V83	1.84	No	No	0	9	6
1004	K:K:A2	K:K:A6	1.79	No	No	0	9	9
1005	K:K:A358	K:K:A372	1.79	Yes	No	0	8	8
1006	R:R:A150	R:R:A197	1.79	No	No	0	6	4
1007	R:R:A154	R:R:A197	1.79	No	No	0	7	4
1008	K:K:G304	K:K:I333	1.76	No	No	0	9	9
1009	K:K:G355	K:K:I402	1.76	No	No	0	9	8
1010	K:K:P24	K:K:T23	1.75	No	No	0	7	6
1011	K:K:G569	K:K:M568	1.75	No	No	0	6	7
1012	R:R:P361	R:R:T84	1.75	No	No	0	9	9
1013	K:K:G387	K:K:K383	1.74	No	Yes	0	8	9
1014	K:K:G441	K:K:L440	1.71	No	No	0	3	1
1015	R:R:A214	R:R:S52	1.71	No	No	0	1	6
1016	R:R:G77	R:R:L116	1.71	No	No	0	8	7
1017	R:R:C315	R:R:V314	1.71	No	No	0	9	6
1018	R:R:C315	R:R:V355	1.71	No	No	0	9	5
1019	K:K:A28	K:K:V525	1.7	No	No	0	8	7
1020	K:K:A339	K:K:V313	1.7	No	Yes	0	9	8
1021	K:K:A349	K:K:V351	1.7	No	No	0	9	9
1022	K:K:G548	K:K:N544	1.7	No	No	0	2	4
1023	R:R:A351	R:R:V69	1.7	No	No	0	5	4
1024	R:R:G221	R:R:N211	1.7	No	No	0	2	2
1025	R:R:A260	R:R:V302	1.7	No	No	0	6	7
1026	R:R:A270	R:R:V295	1.7	No	No	0	5	3
1027	K:K:A22	K:K:T23	1.68	No	No	0	5	6
1028	K:K:A25	K:K:T528	1.68	No	No	0	8	5
1029	R:R:M120	R:R:P121	1.68	Yes	No	0	8	9
1030	K:K:G134	K:K:Q133	1.64	No	Yes	0	1	3
1031	K:K:C154	K:K:I150	1.64	No	No	0	4	2
1032	K:K:E476	K:K:G475	1.64	No	No	0	9	6
1033	R:R:E209	R:R:G137	1.64	Yes	No	0	5	8
1034	K:K:S125	K:K:S127	1.63	No	No	0	3	1
1035	K:K:N570	K:K:P571	1.63	No	No	0	7	5
1036	K:K:A482	K:K:I196	1.62	No	Yes	0	8	9
1037	R:R:S253	R:R:V309	1.62	No	No	0	5	8
1038	K:K:A367	K:K:K346	1.61	No	No	0	4	5
1039	K:K:A650	K:K:M603	1.61	No	Yes	0	6	7
1040	K:K:A654	K:K:M603	1.61	No	Yes	0	8	7
1041	K:K:V11	K:K:V7	1.6	No	Yes	0	9	9
1042	K:K:V246	K:K:V313	1.6	No	Yes	0	8	8
1043	R:R:V235	R:R:V236	1.6	No	No	0	4	6
1044	R:R:V235	R:R:V239	1.6	No	No	0	4	5
1045	R:R:V250	R:R:V254	1.6	No	No	0	3	5
1046	K:K:G287	K:K:H286	1.59	No	No	0	7	8
1047	K:K:G365	K:K:H348	1.59	No	No	0	8	6
1048	K:K:G594	K:K:H549	1.59	No	No	0	5	2
1049	R:R:T257	R:R:V254	1.59	No	No	0	3	5
1050	R:R:T264	R:R:V302	1.59	No	No	0	5	7
1051	R:R:A214	R:R:L54	1.58	No	No	0	1	5
1052	R:R:A85	R:R:L110	1.58	No	No	0	8	6
1053	K:K:E476	K:K:P473	1.57	No	No	0	9	9
1054	R:R:E291	R:R:P292	1.57	No	No	0	4	3
1055	K:K:D3	R:R:A369	1.54	Yes	No	0	9	4
1056	K:K:A480	K:K:D484	1.54	No	No	0	9	9
1057	R:R:I60	R:R:V64	1.54	No	No	0	2	6
1058	R:R:I246	R:R:V250	1.54	No	No	0	5	3
1059	R:R:I359	R:R:V355	1.54	No	No	0	6	5
1060	K:K:M257	K:K:S244	1.53	No	No	0	9	8
1061	K:K:M15	K:K:V11	1.52	No	No	0	9	9
1062	K:K:A654	K:K:E653	1.51	No	No	0	8	1
1063	R:R:M207	R:R:T206	1.51	Yes	No	0	6	5
1064	K:K:G249	K:K:R311	1.5	No	No	0	8	6
1065	R:R:K175	R:R:T178	1.5	No	No	0	4	4
1066	R:R:L366	R:R:V304	1.49	No	No	0	6	8
1067	K:K:D169	K:K:S168	1.47	No	No	0	4	9
1068	K:K:L235	K:K:T234	1.47	No	No	0	9	5
1069	R:R:D59	R:R:S62	1.47	No	No	0	3	3
1070	R:R:L71	R:R:T67	1.47	No	No	0	5	6
1071	R:R:L338	R:R:T335	1.47	No	No	0	1	4
1072	K:K:A321	K:K:H280	1.46	No	Yes	0	9	9
1073	R:R:N261	R:R:T257	1.46	No	No	0	4	3
1074	R:R:N261	R:R:T264	1.46	No	No	0	4	5
1075	K:K:I529	K:K:K31	1.45	Yes	No	0	5	6
1076	K:K:F572	K:K:P571	1.44	No	No	0	7	5
1077	K:K:E360	K:K:V366	1.43	Yes	No	0	9	5
1078	K:K:Q577	K:K:T574	1.42	Yes	No	0	8	6
1079	K:K:E107	K:K:T111	1.41	No	No	0	3	1
1080	K:K:K545	K:K:N544	1.4	No	No	0	5	4
1081	K:K:A9	K:K:R195	1.38	No	Yes	0	9	9
1082	K:K:A531	K:K:R535	1.38	No	No	0	1	5
1083	K:K:L82	K:K:N156	1.37	No	No	0	4	4
1084	R:R:H229	R:R:T232	1.37	No	No	0	4	4
1085	K:K:K545	K:K:Q546	1.36	No	No	0	5	1
1086	K:K:K623	K:K:Q607	1.36	No	No	0	3	3
1087	K:K:E327	K:K:K21	1.35	No	No	0	9	5
1088	K:K:E491	K:K:K494	1.35	No	No	0	7	8
1089	K:K:E551	K:K:K540	1.35	No	No	0	4	4
1090	R:R:R184	R:R:S181	1.32	No	No	0	5	8
1091	R:R:R306	R:R:V302	1.31	No	No	0	5	7
1092	K:K:D398	K:K:E401	1.3	No	No	0	7	8
1093	R:R:D331	R:R:E332	1.3	No	No	0	1	1
1094	R:R:F337	R:R:T335	1.3	No	No	0	2	4
1095	K:K:Q656	K:K:Q659	1.28	No	No	0	5	3
1096	K:K:E616	K:K:Q613	1.27	No	No	0	3	1
1097	R:R:K186	R:R:R182	1.24	No	No	0	3	3
1098	R:R:I189	R:R:Y103	1.21	No	No	0	7	5
1099	R:R:L366	R:R:R303	1.21	No	No	0	6	7
1100	K:K:D455	K:K:R454	1.19	No	No	0	1	1
1101	K:K:F162	K:K:Q163	1.17	Yes	No	0	8	1
1102	K:K:Q656	K:K:R652	1.17	No	No	0	5	3
1103	K:K:E610	K:K:R648	1.16	No	Yes	0	4	4
1104	K:K:R535	K:K:R539	1.07	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	K:K:D3	5.4025	4	0	9
2	K:K:V7	4.7525	4	0	9
3	K:K:Y13	5.99714	7	3	9
4	K:K:L34	6.585	6	1	8
5	K:K:P35	5.345	4	1	5
6	K:K:Y46	8.672	5	7	4
7	K:K:F55	8.73	5	5	7
8	K:K:F59	9.99	4	5	7
9	K:K:Y65	6.025	4	5	5
10	K:K:F68	8.4775	4	0	8
11	K:K:F71	5.714	5	12	5
12	K:K:L76	4.194	5	12	2
13	K:K:F85	8.18	7	5	8
14	K:K:Y86	6.94	5	5	7
15	K:K:Y92	6.916	5	5	5
16	K:K:R101	7.434	5	5	7
17	K:K:I108	4.76	4	5	5
18	K:K:F109	6.48	4	0	3
19	K:K:I113	7.855	4	5	5
20	K:K:H122	7.01714	7	5	3
21	K:K:F124	9.14333	6	5	3
22	K:K:I129	3.9625	4	5	2
23	K:K:Q133	3.2725	4	0	3
24	K:K:L145	5.8875	4	5	4
25	K:K:F146	6.67333	6	5	8
26	K:K:Y149	7.90714	7	5	4
27	K:K:F162	6.6925	4	0	8
28	K:K:F171	6.3925	4	18	5
29	K:K:R173	7.13714	7	1	9
30	K:K:F174	5.015	4	0	7
31	K:K:W177	7.69429	7	1	9
32	K:K:N179	7.198	5	1	6
33	K:K:E181	8.9775	4	1	9
34	K:K:L186	6.4525	4	1	8
35	K:K:F191	7.05	6	1	9
36	K:K:H194	5.775	4	0	9
37	K:K:R195	6.3725	4	3	9
38	K:K:I196	4.78	4	19	9
39	K:K:R199	5.3125	4	0	9
40	K:K:F202	4.864	5	0	9
41	K:K:E204	5.544	5	19	9
42	K:K:Y206	6.8675	4	19	8
43	K:K:R209	5.0175	4	0	9
44	K:K:K210	8.76167	6	1	8
45	K:K:T213	8.42	4	1	9
46	K:K:Y217	8.42333	6	1	9
47	K:K:M219	5.242	5	1	8
48	K:K:K220	6.0775	4	3	9
49	K:K:K224	8.2025	4	3	9
50	K:K:R226	7.0625	4	0	9
51	K:K:E239	5.905	4	3	9
52	K:K:R240	5.6575	4	3	9
53	K:K:L243	6.43	4	3	9
54	K:K:P252	5.4125	4	4	7
55	K:K:F253	8.498	5	4	9
56	K:K:Y259	6.21375	8	1	9
57	K:K:H262	5.445	4	3	8
58	K:K:L267	7.4725	4	3	9
59	K:K:F269	5.926	5	3	8
60	K:K:I270	7.5325	4	1	8
61	K:K:L279	5.0225	4	0	9
62	K:K:H280	4.015	4	0	9
63	K:K:Y281	9.2675	4	8	9
64	K:K:H282	7.072	5	8	9
65	K:K:F289	5.6075	4	0	8
66	K:K:M294	5.8375	4	4	8
67	K:K:F296	8.91	5	4	9
68	K:K:Y297	6.504	5	4	9
69	K:K:E300	9.032	5	4	9
70	K:K:L303	6.3375	4	4	7
71	K:K:V313	2.71	4	0	8
72	K:K:Y315	6.09667	6	3	9
73	K:K:D317	7.275	4	3	9
74	K:K:N322	6.175	4	3	9
75	K:K:H330	9.94	5	4	9
76	K:K:F342	9.315	4	0	6
77	K:K:Y356	6.994	5	3	9
78	K:K:A358	3.8425	4	0	8
79	K:K:P359	5.7	5	9	9
80	K:K:E360	5.33857	7	9	9
81	K:K:L362	6.2925	4	0	6
82	K:K:Y368	9.555	4	0	9
83	K:K:S371	5.7325	4	9	8
84	K:K:D373	6.5425	4	0	9
85	K:K:W374	6.1525	4	21	7
86	K:K:F375	6.945	6	9	8
87	K:K:F382	8.27	5	4	6
88	K:K:K383	5.5075	4	3	9
89	K:K:R386	6.758	5	4	5
90	K:K:P390	9.01	4	0	9
91	K:K:L413	4.9075	4	4	7
92	K:K:F417	5.32286	7	4	7
93	K:K:L421	7.995	4	4	5
94	K:K:L424	4.5975	4	4	5
95	K:K:V433	5.56	4	9	5
96	K:K:R436	7.21143	7	9	9
97	K:K:K448	7.648	5	4	7
98	K:K:F452	8.81	5	4	6
99	K:K:F453	7.04	4	4	8
100	K:K:W458	7.916	5	4	7
101	K:K:Q464	6.5025	4	4	5
102	K:K:Y466	6.955	4	0	3
103	K:K:P472	4.16667	6	8	9
104	K:K:V477	5.7175	4	3	8
105	K:K:N478	4.424	5	8	9
106	K:K:Y506	5.685	6	3	9
107	K:K:F509	6.652	5	3	9
108	K:K:R516	8.228	5	1	9
109	K:K:W517	8.354	5	1	9
110	K:K:Q518	6.968	5	1	9
111	K:K:E520	9.698	5	1	9
112	K:K:F526	7.83167	6	1	8
113	K:K:I529	3.635	4	1	5
114	K:K:L555	8.7575	4	6	4
115	K:K:M561	5.6525	4	7	4
116	K:K:H562	11.014	5	6	7
117	K:K:M565	10.215	4	0	5
118	K:K:W576	7.9725	4	0	8
119	K:K:Q577	5.4075	4	13	8
120	K:K:Y580	9.24667	6	6	8
121	K:K:F581	7.69	4	13	6
122	K:K:Y582	6.795	4	6	5
123	K:K:W590	9.8875	4	13	5
124	K:K:R591	9.03	4	6	5
125	K:K:L601	4.5575	4	10	4
126	K:K:M603	2.22	4	0	7
127	K:K:I606	6.9825	4	10	4
128	K:K:I624	4.27	4	10	3
129	K:K:Q633	6.9125	4	0	7
130	K:K:P638	6.5325	4	7	8
131	K:K:E639	6.77	4	1	6
132	K:K:Q642	7.1875	4	7	8
133	K:K:R648	8.615	4	10	4
134	K:K:Y651	6.572	5	10	5
135	K:K:?701	9.175	10	3	0
136	L:L:P10	9.6525	4	2	0
137	L:L:Y11	5.455	4	0	0
138	L:L:I12	7.355	6	2	0
139	L:L:L13	7.492	5	2	0
140	R:R:E53	6.22	4	2	2
141	R:R:V56	6.5175	4	2	2
142	R:R:T58	5.7975	4	2	1
143	R:R:Y70	6.074	5	2	7
144	R:R:F74	5.9175	4	0	7
145	R:R:L108	5.4325	4	11	9
146	R:R:T115	4.625	4	0	7
147	R:R:M120	6.165	4	2	8
148	R:R:E123	6.615	6	2	6
149	R:R:F127	5.418	5	2	4
150	R:R:H132	5.866	5	14	4
151	R:R:P133	4.3325	4	14	5
152	R:R:W134	6.74333	6	15	8
153	R:R:Y144	7.892	5	2	6
154	R:R:Y145	9.685	4	2	4
155	R:R:R148	7.4125	4	2	7
156	R:R:D149	8.72	4	16	5
157	R:R:L157	6.955	4	0	6
158	R:R:E165	8.71	4	0	8
159	R:R:Y167	5.77	4	0	8
160	R:R:F174	5.55	4	0	7
161	R:R:V201	6.9475	4	0	5
162	R:R:L204	7.6425	4	16	5
163	R:R:F205	10.51	4	2	4
164	R:R:M207	7.1	4	0	6
165	R:R:E209	6.1675	4	15	5
166	R:R:C224	6.8225	4	15	9
167	R:R:P226	5.67	5	2	5
168	R:R:N240	9.33	4	16	6
169	R:R:W316	10.1875	4	2	8
170	R:R:R322	6.55333	6	2	5
171	R:R:F326	4.645	4	2	4
172	R:R:Y342	5.83833	6	2	4
173	R:R:H343	7.9375	4	2	4
174	R:R:Y344	5.815	4	2	1
175	R:R:Y346	8.888	5	2	4
176	R:R:N350	5.79	5	2	6
177	R:R:F353	7.086	5	2	7
178	R:R:Y354	7.54125	8	2	7
179	R:R:F371	4.7425	4	0	8
180	R:R:F375	7.5425	4	0	7
181	W:W:?1	9.81273	11	11	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L108	R:R:V159	10.8152	4.47	Yes	No	0	9	8
2	R:R:L108	R:R:N158	69.7176	6.87	Yes	No	0	9	8
3	R:R:N158	R:R:S161	70.4261	2.98	No	No	0	8	7
4	R:R:H104	R:R:S161	70.5434	8.37	No	No	0	8	7
5	R:R:E165	R:R:H104	70.6605	11.08	Yes	No	0	8	8
6	R:R:E165	R:R:M180	71.0105	13.53	Yes	No	0	8	7
7	R:R:A176	R:R:M180	71.3586	3.22	No	No	0	6	7
8	R:R:A176	R:R:L168	71.4742	4.73	No	No	0	6	4
9	R:R:K175	R:R:L168	71.7047	2.82	No	No	0	4	4
10	R:R:H172	R:R:K175	71.9343	13.1	No	No	0	6	4
11	R:R:F174	R:R:H172	72.1631	2.26	Yes	No	0	7	6
12	K:K:A211	R:R:F174	74.5125	2.77	No	Yes	0	8	7
13	K:K:A211	K:K:K30	74.6219	4.82	No	No	0	8	9
14	K:K:D212	K:K:K30	74.7312	6.91	No	No	0	8	9
15	K:K:D212	K:K:K210	74.5344	12.44	No	Yes	1	8	8
16	K:K:F191	K:K:K210	49.4714	8.69	Yes	Yes	1	9	8
17	K:K:F191	K:K:M219	24.6323	4.98	Yes	Yes	1	9	8
18	K:K:M219	K:K:S268	50.3893	7.67	Yes	No	0	8	8
19	K:K:C221	K:K:S268	100	3.44	No	No	0	9	8
20	K:K:C221	K:K:Y206	99.8389	4.03	No	Yes	0	9	8
21	K:K:I196	K:K:Y206	95.2632	6.04	Yes	Yes	19	9	8
22	K:K:I196	K:K:I485	95.9068	7.36	Yes	No	0	9	9
23	K:K:G198	K:K:I485	95.2392	3.53	No	No	0	9	9
24	K:K:?701	K:K:G198	95.0718	7.4	Yes	No	0	0	9
25	K:K:?701	K:K:I197	17.061	19.41	Yes	No	3	0	9
26	K:K:I197	K:K:Y13	17.2613	3.63	No	Yes	3	9	9
27	K:K:F191	K:K:F261	24.4761	4.29	Yes	No	1	9	8
28	K:K:F261	K:K:S268	49.7723	13.21	No	No	0	8	8
29	K:K:K210	K:K:Y259	25.4563	9.55	Yes	Yes	1	8	9
30	K:K:W517	K:K:Y259	75.4481	8.68	Yes	Yes	1	9	9
31	K:K:V521	K:K:W517	21.8994	8.58	No	Yes	0	8	9
32	K:K:V521	K:K:W177	21.7604	3.68	No	Yes	0	8	9
33	K:K:L34	K:K:W177	17.4748	14.81	Yes	Yes	1	8	9
34	K:K:L34	K:K:P35	17.2059	3.28	Yes	Yes	1	8	5
35	K:K:N179	K:K:P35	10.2022	4.89	Yes	Yes	1	6	5
36	K:K:D635	K:K:E639	18.2853	7.8	No	Yes	0	4	6
37	K:K:D635	K:K:R578	17.9095	9.53	No	No	0	4	6
38	K:K:R578	K:K:Y564	11.1073	13.38	No	No	0	6	4
39	K:K:Y564	K:K:Y580	10.7274	13.9	No	Yes	0	4	8
40	K:K:Q518	K:K:W517	30.2721	3.29	Yes	Yes	1	9	9
41	K:K:Q518	K:K:Q61	28.7487	12.8	Yes	No	0	9	9
42	K:K:F174	K:K:Q61	31.4047	5.86	Yes	No	0	7	9
43	K:K:F174	K:K:I58	33.7628	7.54	Yes	No	0	7	7
44	K:K:F162	K:K:I58	33.59	5.02	Yes	No	0	8	7
45	K:K:F162	K:K:F55	33.0704	11.79	Yes	Yes	0	8	7
46	K:K:F55	K:K:F59	26.0783	15	Yes	Yes	5	7	7
47	K:K:E181	K:K:W517	23.1465	14.17	Yes	Yes	1	9	9
48	K:K:E181	K:K:K178	23.0276	9.45	Yes	No	0	9	9
49	K:K:E52	K:K:K178	25.9166	5.4	No	No	0	5	9
50	K:K:E52	K:K:R50	24.8497	3.49	No	No	0	5	3
51	K:K:R50	K:K:Y46	24.6784	18.52	No	Yes	0	3	4
52	K:K:Q642	K:K:Y46	24.9667	7.89	Yes	Yes	7	8	4
53	K:K:K45	K:K:Q642	12.1267	4.07	No	Yes	7	6	8
54	K:K:K45	K:K:M561	11.9409	4.32	No	Yes	7	6	4
55	K:K:E646	K:K:Q642	12.1267	7.65	No	Yes	7	8	8
56	K:K:E646	K:K:M561	11.9409	4.06	No	Yes	7	8	4
57	K:K:F59	K:K:Y86	19.4768	10.32	Yes	Yes	5	7	7
58	K:K:I153	K:K:Y86	13.2715	3.63	No	Yes	5	5	7
59	K:K:L186	K:K:Y259	25.6734	4.69	Yes	Yes	1	8	9
60	K:K:I270	K:K:Y259	25.5689	7.25	Yes	Yes	1	8	9
61	K:K:?701	K:K:K220	14.6663	8.72	Yes	Yes	3	0	9
62	K:K:?701	K:K:D335	68.5779	6.71	Yes	No	3	0	9
63	K:K:D317	K:K:D335	30.2273	3.99	Yes	No	3	9	9
64	K:K:D317	K:K:Y315	20.8788	3.45	Yes	Yes	3	9	9
65	K:K:M308	K:K:Y315	17.0362	8.38	No	Yes	0	9	9
66	K:K:I254	K:K:M308	16.5722	4.37	No	No	0	9	9
67	K:K:H307	K:K:I254	16.1169	6.63	No	No	0	8	9
68	K:K:D335	K:K:N322	38.1593	5.39	No	Yes	3	9	9
69	K:K:N322	K:K:Y315	20.8397	6.98	Yes	Yes	3	9	9
70	K:K:C251	K:K:H307	12.0747	16.22	No	No	0	8	8
71	K:K:C251	K:K:F253	10.2359	4.19	No	Yes	4	8	9
72	K:K:K319	K:K:N322	17.5737	5.6	No	Yes	3	9	9
73	K:K:K319	K:K:Y356	17.1189	5.97	No	Yes	3	9	9
74	K:K:D373	K:K:Y315	22.688	3.45	Yes	Yes	0	9	9
75	K:K:D373	K:K:L305	16.1138	4.07	Yes	No	0	9	9
76	K:K:L305	K:K:L377	14.7022	4.15	No	No	21	9	6
77	K:K:L377	K:K:L381	14.4101	6.92	No	No	0	6	5
78	K:K:L381	K:K:M294	13.5687	4.24	No	Yes	0	5	8
79	K:K:S389	K:K:Y356	11.3062	12.72	No	Yes	0	8	9
80	K:K:M561	K:K:W643	23.1246	8.14	Yes	No	0	4	9
81	K:K:M565	K:K:W643	20.8359	20.94	Yes	No	0	5	9
82	K:K:C634	K:K:M565	15.1202	3.24	No	Yes	0	6	5
83	K:K:C634	K:K:L640	14.7366	6.35	No	No	0	6	5
84	K:K:L620	K:K:L640	14.3528	4.15	No	No	0	7	5
85	R:R:D112	R:R:N360	64.0553	6.73	No	No	0	9	9
86	R:R:D112	R:R:S357	63.237	10.31	No	No	0	9	9
87	R:R:S357	R:R:T115	63.0999	6.4	No	Yes	0	9	7
88	R:R:F353	R:R:T115	61.482	3.89	Yes	Yes	0	7	7
89	R:R:F353	R:R:Y319	30.4711	6.19	Yes	No	0	7	6
90	R:R:R322	R:R:Y319	20.424	6.17	Yes	No	0	5	6
91	R:R:R322	R:R:Y342	10.922	6.17	Yes	Yes	2	5	4
92	R:R:L108	R:R:N360	62.4364	6.87	Yes	No	11	9	9
93	L:L:I12	L:L:Y11	17.1659	3.63	Yes	Yes	0	0	0
94	R:R:F353	R:R:Y354	28.206	14.44	Yes	Yes	2	7	7
95	R:R:E123	R:R:Y354	11.4347	11.22	Yes	Yes	2	6	7
96	L:L:Y11	R:R:V223	12.7317	8.83	Yes	No	0	0	4
97	R:R:S213	R:R:V223	11.9845	3.23	No	No	0	1	4
98	R:R:R323	R:R:Y319	11.8923	7.2	No	No	0	6	6
99	K:K:F261	K:K:L186	25.3512	9.74	No	Yes	1	8	8
100	K:K:I270	K:K:M219	25.9807	4.37	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R8	R:R:E53	4.65	2	No	Yes	0	2	0	1
L:L:R8	R:R:R212	5.33	2	No	No	0	1	0	1
L:L:R8	R:R:Y339	11.32	2	No	No	0	2	0	1
L:L:R9	R:R:F326	6.41	0	No	Yes	0	4	0	1
L:L:P10	R:R:W334	16.21	2	Yes	No	0	4	0	1
L:L:P10	R:R:Y339	6.95	2	Yes	No	0	2	0	1
L:L:P10	R:R:Y342	11.13	2	Yes	Yes	0	4	0	1
L:L:Y11	R:R:E53	5.61	0	Yes	Yes	0	2	0	1
L:L:Y11	R:R:V223	8.83	0	Yes	No	0	4	0	1
L:L:Y11	R:R:T225	3.75	0	Yes	No	0	4	0	1
L:L:I12	R:R:F127	5.02	2	Yes	Yes	0	4	0	1
L:L:I12	R:R:H131	11.93	2	Yes	No	0	3	0	1
L:L:I12	R:R:Y342	6.04	2	Yes	Yes	0	4	0	1
L:L:I12	R:R:H343	6.63	2	Yes	Yes	0	4	0	1
L:L:I12	R:R:Y346	10.88	2	Yes	Yes	0	4	0	1
L:L:L13	R:R:Y145	15.24	2	Yes	Yes	0	4	0	1
L:L:L13	R:R:F205	7.31	2	Yes	Yes	0	4	0	1
L:L:L13	R:R:P226	6.57	2	Yes	Yes	0	5	0	1
L:L:L13	R:R:F326	3.65	2	Yes	Yes	0	4	0	1
L:L:L13	R:R:Y346	4.69	2	Yes	Yes	0	4	0	1
R:R:E53	R:R:N57	7.89	2	Yes	No	2	2	1	2
R:R:E53	R:R:Y339	6.73	2	Yes	No	2	2	1	1
R:R:H131	R:R:V56	11.07	2	No	Yes	3	2	1	2
R:R:H343	R:R:V56	4.15	2	Yes	Yes	4	2	1	2
R:R:E123	R:R:F127	3.5	2	Yes	Yes	6	4	2	1
R:R:E123	R:R:Y144	3.37	2	Yes	Yes	6	6	2	2
R:R:E123	R:R:N350	7.89	2	Yes	Yes	6	6	2	2
R:R:F127	R:R:Y144	5.16	2	Yes	Yes	4	6	1	2
R:R:F127	R:R:Y145	5.16	2	Yes	Yes	4	4	1	1
R:R:F127	R:R:Y346	8.25	2	Yes	Yes	4	4	1	1
R:R:H131	R:R:H343	15.53	2	No	Yes	3	4	1	1
R:R:Y144	R:R:Y145	5.96	2	Yes	Yes	6	4	2	1
R:R:F205	R:R:Y145	12.38	2	Yes	Yes	4	4	1	1
R:R:F205	R:R:M207	13.68	2	Yes	Yes	4	6	1	2
R:R:F205	R:R:P226	8.67	2	Yes	Yes	4	5	1	1
R:R:Q210	R:R:R212	5.84	0	No	No	1	1	2	1
R:R:Q210	R:R:T225	5.67	0	No	No	1	4	2	1
R:R:P226	R:R:T225	5.25	2	Yes	No	5	4	1	1
R:R:P226	R:R:V233	3.53	2	Yes	No	5	5	1	2
R:R:F326	R:R:P226	4.33	2	Yes	Yes	4	5	1	1
R:R:C327	R:R:V233	3.42	0	No	No	3	5	2	2
R:R:R322	R:R:Y342	6.17	2	Yes	Yes	5	4	2	1
R:R:R322	R:R:Y346	11.32	2	Yes	Yes	5	4	2	1
R:R:N350	R:R:R322	3.62	2	Yes	Yes	6	5	2	2
R:R:C327	R:R:F326	4.19	0	No	Yes	3	4	2	1
R:R:I329	R:R:W334	4.7	0	No	No	3	4	2	1
R:R:W334	R:R:Y342	3.86	2	No	Yes	4	4	1	1
R:R:H343	R:R:Y342	5.44	2	Yes	Yes	4	4	1	1
R:R:N350	R:R:Y346	9.3	2	Yes	Yes	6	4	2	1
R:R:S213	R:R:V223	3.23	0	No	No	1	4	2	1
R:R:M325	R:R:Y342	2.39	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
K:K:D3	R:R:S368	7.36	0	Yes	No	9	8	2	1
K:K:L4	K:K:L8	6.92	0	No	No	9	9	1	2
K:K:L4	R:R:G301	3.42	0	No	No	9	8	1	2
K:K:L4	W:W:?1	8.51	0	No	Yes	9	0	1	0
K:K:E5	R:R:H102	4.92	0	No	No	9	8	1	2
K:K:E5	W:W:?1	11.77	0	No	Yes	9	0	1	0
K:K:L8	R:R:R166	3.64	0	No	No	9	9	2	1
R:R:F371	R:R:T84	3.89	0	Yes	No	8	9	1	2
R:R:F371	R:R:T87	3.89	0	Yes	No	8	7	1	2
R:R:L105	R:R:L162	4.15	11	No	No	8	9	1	1
R:R:L105	R:R:Y364	10.55	11	No	No	8	9	1	2
R:R:L105	W:W:?1	6.62	11	No	Yes	8	0	1	0
R:R:L108	R:R:V159	4.47	11	Yes	No	9	8	2	1
R:R:L108	R:R:Y364	3.52	11	Yes	No	9	9	2	2
R:R:I252	R:R:V159	4.61	0	No	No	8	8	2	1
R:R:V159	W:W:?1	4.07	0	No	Yes	8	0	1	0
R:R:L162	W:W:?1	9.46	11	No	Yes	9	0	1	0
R:R:R166	W:W:?1	27.39	0	No	Yes	9	0	1	0
R:R:I252	R:R:N256	4.25	0	No	No	8	9	2	2
R:R:L305	R:R:N256	5.49	0	No	No	8	9	1	2
R:R:V304	R:R:V367	8.02	0	No	No	8	7	2	1
R:R:L305	W:W:?1	4.73	0	No	Yes	8	0	1	0
R:R:V308	W:W:?1	19.34	0	No	Yes	8	0	1	0
R:R:V367	W:W:?1	5.09	0	No	Yes	7	0	1	0
R:R:S368	W:W:?1	5.13	0	No	Yes	8	0	1	0
R:R:F371	R:R:F375	5.36	0	Yes	Yes	8	7	1	2
R:R:F371	W:W:?1	5.83	0	Yes	Yes	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JPC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	910
Number of Links	1104
Number of Hubs	181
Number of Links mediated by Hubs	642
Number of Communities	21
Number of Nodes involved in Communities	235
Number of Links involved in Communities	355

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	1477058
Length Of Smallest Path	3
Average Path Length	31.242
Length of Longest Path	63
Minimum Path Strength	1.225
Average Path Strength	6.99242
Maximum Path Strength	23.365
Minimum Path Correlation	0.7
Average Path Correlation	0.991572
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	57.1334
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3387
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • cytosolic region • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • catalytic activity, acting on a protein • beta-adrenergic receptor kinase activity • kinase activity • protein kinase activity • transferase activity • catalytic activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • Edg-2 lysophosphatidic acid receptor binding • protein binding • binding • signaling receptor binding • endothelial differentiation G protein-coupled receptor binding • G protein-coupled receptor binding • adenyl ribonucleotide binding • nucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • adenyl nucleotide binding • ATP binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • adrenergic receptor binding • alpha-2A adrenergic receptor binding • protein serine/threonine kinase activity • G protein-coupled receptor kinase activity • regulation of localization • regulation of biological process • regulation of protein localization • protein localization to cilium • biological regulation • positive regulation of biological process • positive regulation of protein localization to cilium • regulation of protein localization to cilium • localization • macromolecule localization • protein localization to organelle • positive regulation of protein localization • intracellular protein localization • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • regulation of system process • negative regulation of biological process • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • negative regulation of muscle contraction • regulation of striated muscle contraction • regulation of muscle contraction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • negative regulation of striated muscle contraction • heart process • regulation of heart contraction • circulatory system process • regulation of blood circulation • regulation of biological quality • heart contraction • regulation of the force of heart contraction • blood circulation • cellular response to stimulus • regulation of signaling • regulation of cellular process • response to stimulus • signaling • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • biological process involved in interspecies interaction between organisms • symbiont entry into host cell • viral process • symbiont entry into host • viral life cycle • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral genome replication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of smoothened signaling pathway • positive regulation of cellular process • regulation of smoothened signaling pathway • cell surface receptor signaling pathway • smoothened signaling pathway • positive regulation of signaling • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • G protein-coupled receptor signaling pathway • cellular localization • establishment of protein localization • nitrogen compound transport • transport • intracellular transport • establishment of localization • protein transport • establishment of localization in cell • intracellular protein transport • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • negative regulation of blood circulation • negative regulation of heart contraction • negative regulation of the force of heart contraction by chemical signal • regulation of the force of heart contraction by chemical signal • protein phosphorylation • phosphorylation • primary metabolic process • macromolecule modification • phosphate-containing compound metabolic process • metabolic process • protein metabolic process • macromolecule metabolic process • protein modification process • phosphorus metabolic process • cardiac muscle contraction • tachykinin receptor signaling pathway • negative regulation of relaxation of smooth muscle • relaxation of smooth muscle • negative regulation of relaxation of muscle • relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • import into cell • receptor internalization • vesicle-mediated transport • G protein-coupled receptor internalization • receptor-mediated endocytosis • endocytosis • presynapse • mitochondrial membrane • mitochondrion • organelle outer membrane • cytoplasmic side of mitochondrial outer membrane • mitochondrial envelope • mitochondrial outer membrane • outer membrane • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled neurotensin receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • protein-containing complex binding • identical protein binding • neuropeptide signaling pathway • adult locomotory behavior • behavior • adult behavior • locomotory behavior • learning • learning or memory • nervous system process • cognition • regulation of calcium ion transport • intracellular calcium ion homeostasis • negative regulation of transport • calcium ion transport • negative regulation of cation transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • negative regulation of calcium ion transmembrane transport • inorganic ion homeostasis • homeostatic process • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • negative regulation of transmembrane transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of sequestering of calcium ion • negative regulation of monoatomic ion transmembrane transport • negative regulation of release of sequestered calcium ion into cytosol • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • monoatomic ion transport • intracellular chemical homeostasis • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • negative regulation of calcium ion transport • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • positive regulation of inhibitory postsynaptic potential • positive regulation of nervous system process • modulation of inhibitory postsynaptic potential • trans-synaptic signaling • regulation of nervous system process • chemical synaptic transmission • anterograde trans-synaptic signaling • inhibitory postsynaptic potential • positive regulation of multicellular organismal process • regulation of membrane potential • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • regulation of metabolic process • positive regulation of programmed cell death • positive regulation of apoptotic process • organic anion transport • carboxylic acid transport • carboxylic acid transmembrane transport • aspartate transmembrane transport • import across plasma membrane • amino acid transmembrane transport • C4-dicarboxylate transport • D-amino acid transport • organic acid transport • amino acid transport • acidic amino acid transport • D-aspartate transmembrane transport • D-aspartate import across plasma membrane • dicarboxylic acid transport • amino acid import across plasma membrane • positive regulation of arachidonate secretion • regulation of lipid transport • regulation of arachidonate secretion • arachidonate secretion • monocarboxylic acid transport • positive regulation of secretion • fatty acid transport • icosanoid transport • regulation of icosanoid secretion • icosanoid secretion • long-chain fatty acid transport • positive regulation of icosanoid secretion • secretion • arachidonate transport • lipid localization • lipid transport • positive regulation of lipid localization • regulation of fatty acid transport • regulation of secretion • positive regulation of organic acid transport • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • regulation of organic acid transport • positive regulation of fatty acid transport • regulation of membrane depolarization • membrane depolarization • polyol metabolic process • alcohol catabolic process • catabolic process • polyol catabolic process • organophosphate catabolic process • alcohol metabolic process • inositol phosphate metabolic process • organophosphate metabolic process • inositol phosphate catabolic process • small molecule metabolic process • small molecule catabolic process • detection of external stimulus • detection of stimulus involved in sensory perception of pain • response to external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • L-glutamate import across plasma membrane • L-amino acid transport • L-glutamate import • L-alpha-amino acid transmembrane transport • L-glutamate transmembrane transport • multicellular organismal-level homeostasis • temperature homeostasis • regulation of systemic arterial blood pressure • regulation of blood pressure • negative regulation of systemic arterial blood pressure • negative regulation of blood pressure • positive regulation of amine transport • gamma-aminobutyric acid transport • regulation of amino acid transport • gamma-aminobutyric acid secretion • regulation of gamma-aminobutyric acid secretion • positive regulation of gamma-aminobutyric acid secretion • acid secretion • amine transport • positive regulation of amino acid transport • regulation of amine transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • response to lipid • regulation of glutamate secretion • positive regulation of secretion by cell • secretion by cell • regulation of secretion by cell • glutamate secretion • positive regulation of glutamate secretion • export from cell • regulation of inositol phosphate biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • polyol biosynthetic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • symmetric synapse • neuron to neuron synapse • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • axon terminus • distal axon • terminal bouton • neuron projection terminus • cell surface • membrane microdomain • membrane raft • dendrite • dendritic tree • dendritic shaft • neuron spine • dendritic spine • endoplasmic reticulum
SCOP2	Domain Identifier	• Protein kinase-like (PK-like) • PH domain-like • Regulator of G-protein signaling, RGS • G protein-coupled receptor-like
SCOP2	Family Identifier	• Protein kinase-like (PK-like) • PH domain-like • Regulator of G-protein signaling, RGS • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ALF
PDB Residues	I:I:?2
Environment Details	Open EMBL-EBI Page
Code	ALF
Name	Tetrafluoroaluminate Ion
Synonyms	Tetrafluoroaluminate Ion Tetrafluoroaluminate anion tetrafluoroaluminate(1−)
Identifier
Formula	Al F4
Molecular Weight	102.975
SMILES
PubChem	5311325
Formal Charge	-1
Total Atoms	5
Total Chiral Atoms	0
Total Bonds	4
Total Aromatic Bonds	0


Code	MG
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	MG
Name	MAGNESIUM ION
Synonyms
Identifier
Formula	Mg
Molecular Weight	24.305
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	STU
PDB Residues	K:K:?701
Environment Details	Open EMBL-EBI Page
Code	STU
Name	Staurosporine
Synonyms	Staurosporine
Identifier
Formula	C28 H26 N4 O3
Molecular Weight	466.531
SMILES
PubChem	44259
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	4
Total Bonds	68
Total Aromatic Bonds	24


Code	GDP
PDB Residues	O:O:?1
Environment Details	Open EMBL-EBI Page
Code	GDP
Name	Guanosine-5'-Diphosphate
Synonyms	Guanosine-5'-Diphosphate
Identifier
Formula	C10 H15 N5 O11 P2
Molecular Weight	443.201
SMILES
PubChem	8977
Formal Charge	0
Total Atoms	43
Total Chiral Atoms	4
Total Bonds	45
Total Aromatic Bonds	5


Code	SRW
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	SRW
Name	2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol
Synonyms
Identifier
Formula	C26 H31 F N4 O2
Molecular Weight	450.548
SMILES
PubChem	118610427
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	0
Total Bonds	68
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	K
Protein	Kinase
UniProt	P21146
Sequence	>8JPC_nogp_Chain_K A D L E A V L A D V S Y L M A M E K S K A T P A A R A S K K I L L P E P S I R S V M Q K Y L E D R G E V T F E K I F S Q K L G Y L L F R D F C L K H L E E A K P L V E F Y E E I K K Y E K L E T E E E R L V C S R E I F D T Y I M K E L L A C S H P F S K S A I E H V Q G H L V K K Q V P P D L F Q P Y I E E I C Q N L R G D V F Q K F I E S D K F T R F C Q W K N V E L N I H L T M N D F S V H R I I G R G G F G E V Y G C R K A D T G K M Y A M K C L D K K R I K M K Q G E T L A L N E R I M L S L V S T G D C P F I V C M S Y A F H T P D K L S F I L D L M N G G D L H Y H L S Q H G V F S E P D M I F Y A A E I I L G L E H M H N R F V V Y R D L K P A N I L L D E H G H V R I S D L G L A C D F S K K K P H A S V G T H G Y M A P E V L Q K G V A Y D S S A D W F S L G C M L F K L L R G H S P F R Q H K T K D K H E I D R M T L T M A V E L P D S F S P E L R S L L E G L L Q R D V N R R L G C L G R G A Q E V K E S P F F R D L D W Q M V F L Q K Y P P P L I P P R G E V N A A D A F D I G S F D E E D T K G I K L L D S D Q E L Y R N F P L T I S E R W Q Q E V A E T V F D T I N A E T D R L E A R K K T K N K Q L G H E E D Y A L G K D C I M H G Y M S K M G N P F L T Q W Q R R Y F Y L F P N R L E W R G E G E A P Q S L L T M E E I Q S V E E T Q I K E R K C L L L K I R G G K Q F V L Q C D S D P E L V Q W K K E L R D A Y R E A Q Q L V Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30989
Sequence	>8JPC_nogp_Chain_R S E L D V N T D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V H H P W A F G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A V P M L F T M G E Q N R S A D G Q H A G G L V C T P T I H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I S D E Q W T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F R H I F L A T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg	Gq; GRK2	3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPB (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg		3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg	Gq; GRK2	3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPC (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg		3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	SBI-553	chim(NtGi1-Go)/β1/γ2	2.89	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN0 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	SBI-553		2.89	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	SBI-553	-	3.02	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8ZYT	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.65	2025-04-09	doi.org/10.1038/s41422-025-01095-7
	8ZYY	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.83	2025-04-09	doi.org/10.1038/s41422-025-01095-7
	8ZYU	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.65	2025-04-16	doi.org/10.1038/s41422-025-01095-7
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.59	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FMZ (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.59	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi1-Go)/β1/γ2	2.88	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN1 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.88	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin-(8-13)	-	-	2.8	2012-10-17	doi.org/10.1038/nature11558
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	doi.org/10.1038/ncomms8895
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	doi.org/10.1038/ncomms8895
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	doi.org/10.1038/s41422-019-0256-2
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OS9 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OSA (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	doi.org/10.1038/s41586-020-1953-1
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.1	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0P (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.1	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.3	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0Q (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.3	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.2	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0R (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.2	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.5	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0S (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.5	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	doi.org/10.1038/srep38564
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	doi.org/10.1073/pnas.1317903111
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	doi.org/10.1126/sciadv.abe5504
	9M0D	A	Peptide	Neurotensin	NTS₁	Homo sapiens	-	-	Arrestin2	3.41	2025-04-09	doi.org/10.1038/s41422-025-01095-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JPC_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.