CodeGDP
NameGuanosine-5'-Diphosphate
SynonymsGuanosine-5'-Diphosphate
Identifier
FormulaC10 H15 N5 O11 P2
Molecular Weight443.201
SMILES
PubChem135398619
Formal Charge0
Total Atoms43
Total Chiral Atoms4
Total Bonds45
Total Aromatic Bonds5
Networks8
 missing image

This ligand is also present in the following 8 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F1O A Amine Dopamine D1 Homo Sapiens Dopamine GDP; Mg Gs/Beta1/Gamma2 3.13 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of GDP in 7F1O
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 0 No No 9 8 1 2
A:A:D223 A:A:L45 4.07 0 No No 9 8 2 2
A:A:G52 A:A:S51 3.71 2 No No 9 9 1 2
A:A:G52 A:A:T55 3.64 2 No No 9 9 1 1
A:A:G52 O:O:?1 4.64 2 No Yes 9 0 1 0
A:A:K53 O:O:?1 6.12 0 No Yes 9 0 1 0
A:A:S54 I:I:?1 5.78 2 No No 9 0 1 1
A:A:S54 O:O:?1 9.78 2 No Yes 9 0 1 0
A:A:T55 O:O:?1 9.6 2 No Yes 9 0 1 0
A:A:D223 I:I:?1 5.22 0 No No 9 0 2 1
A:A:D249 A:A:S251 5.89 2 No No 8 9 2 2
A:A:D249 A:A:K293 19.36 2 No Yes 8 9 2 1
A:A:K293 A:A:S251 4.59 2 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 0 No No 6 9 2 2
A:A:K293 A:A:N292 5.6 2 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 5.85 2 Yes Yes 9 9 1 2
A:A:A366 A:A:N292 4.69 0 No Yes 9 9 2 1
A:A:N292 O:O:?1 4.47 2 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 22.19 2 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 0 No No 9 6 1 2
A:A:C365 A:A:D295 6.22 0 No No 8 9 2 1
A:A:D295 O:O:?1 7.36 0 No Yes 9 0 1 0
I:I:?1 O:O:?1 7.23 2 No Yes 0 0 1 0
A:A:Q59 A:A:T55 2.83 0 No No 9 9 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.92
Average Nodes In Shell19.00
Average Hubs In Shell4.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F1Z A Amine Dopamine D1 Homo Sapiens Dopamine GDP Gs/Beta1/Gamma2 3.46 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of GDP in 7F1Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 7.05 2 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 5.43 2 No Yes 9 8 2 2
A:A:D49 O:O:?1 4.42 0 No Yes 8 0 1 0
A:A:D249 A:A:N50 6.73 2 Yes Yes 8 9 2 2
A:A:K293 A:A:N50 2.8 2 Yes Yes 9 9 1 2
A:A:G52 A:A:T55 5.46 0 No No 9 9 2 1
A:A:D223 A:A:K53 12.44 2 No Yes 9 9 2 1
A:A:K53 A:A:V247 3.04 2 Yes Yes 9 7 1 2
A:A:K53 O:O:?1 8.42 2 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 9.78 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 2 No No 9 9 1 1
A:A:T55 O:O:?1 12 2 No Yes 9 0 1 0
A:A:N292 A:A:V247 4.43 2 Yes Yes 9 7 1 2
A:A:D249 A:A:S251 4.42 2 Yes No 8 9 2 2
A:A:D249 A:A:K293 16.59 2 Yes Yes 8 9 2 1
A:A:K293 A:A:S251 4.59 2 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 2 Yes No 6 9 1 2
A:A:K293 A:A:N292 4.2 2 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 7.31 2 Yes Yes 9 9 1 2
A:A:N292 O:O:?1 5.21 2 Yes Yes 9 0 1 0
A:A:K293 A:A:L296 5.64 2 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 27.54 2 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 2 No Yes 9 6 1 1
A:A:C365 A:A:D295 6.22 0 No No 8 9 2 1
A:A:D295 O:O:?1 4.42 2 No Yes 9 0 1 0
A:A:E299 A:A:L296 3.98 0 No Yes 6 6 2 1
A:A:L296 O:O:?1 6.01 2 Yes Yes 6 0 1 0
A:A:A366 O:O:?1 4.27 2 No Yes 9 0 1 0
A:A:G206 A:A:S54 1.86 0 No No 8 9 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.12
Average Nodes In Shell21.00
Average Hubs In Shell10.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RKF A Other Unclassified US28 Human Betaherpesvirus 5 Fractalkine GDP chim(NtGi1-G11)/Beta1/Gamma2 4 2022-01-26 10.1126/sciadv.abl5442

A 2D representation of the interactions of GDP in 7RKF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G48 A:A:T47 3.64 0 No No 7 8 1 2
A:A:E49 A:A:G48 4.91 13 No No 9 7 2 1
A:A:G48 O:O:?1 1.86 0 No Yes 7 0 1 0
A:A:G51 O:O:?1 6.5 0 No Yes 9 0 1 0
A:A:D205 A:A:K52 2.77 4 No Yes 9 9 2 1
A:A:G207 A:A:K52 3.49 4 No Yes 9 9 2 1
A:A:K52 O:O:?1 8.42 4 Yes Yes 9 0 1 0
A:A:S53 O:O:?1 4.89 0 No Yes 9 0 1 0
A:A:Q58 A:A:T54 4.25 0 No No 9 9 2 1
A:A:T54 O:O:?1 4 0 No Yes 9 0 1 0
A:A:D155 A:A:K275 6.91 0 No No 8 9 2 1
A:A:D155 A:A:L278 4.07 0 No No 8 5 2 1
A:A:R181 A:A:S156 7.91 4 Yes No 6 9 1 1
A:A:S156 O:O:?1 3.26 4 No Yes 9 0 1 0
A:A:Y159 A:A:Y160 1.99 4 Yes No 9 7 2 2
A:A:R181 A:A:Y159 4.12 4 Yes Yes 6 9 1 2
A:A:R181 A:A:Y160 2.06 4 Yes No 6 7 1 2
A:A:R181 A:A:T332 7.76 4 Yes No 6 8 1 1
A:A:R181 O:O:?1 6.59 4 Yes Yes 6 0 1 0
A:A:R183 O:O:?1 8.57 0 No Yes 9 0 1 0
A:A:D205 A:A:G207 3.35 4 No No 9 9 2 2
A:A:L278 A:A:S233 3 0 No No 5 9 1 2
A:A:A331 A:A:N274 4.69 0 No No 9 9 1 2
A:A:K275 O:O:?1 9.95 0 No Yes 9 0 1 0
A:A:C330 A:A:K276 3.23 0 No No 8 5 1 2
A:A:L278 O:O:?1 2.25 0 No Yes 5 0 1 0
A:A:C330 O:O:?1 2.58 0 No Yes 8 0 1 0
A:A:A331 O:O:?1 4.27 0 No Yes 9 0 1 0
A:A:T332 O:O:?1 9.6 4 No Yes 8 0 1 0
A:A:G46 A:A:K52 1.74 0 No Yes 9 9 2 1
A:A:C330 A:A:D277 1.56 0 No No 8 9 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.60
Average Nodes In Shell27.00
Average Hubs In Shell4.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RKY A Other Unclassified US27 Human Betaherpesvirus 5 - GDP Gi1/Beta1/Gamma2 3.8 2022-01-26 doi.org/10.1126/sciadv.abl5442

A 2D representation of the interactions of GDP in 7RKY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K46 A:A:L38 4.23 0 Yes Yes 9 8 1 2
A:A:K46 A:A:S44 3.06 0 Yes No 9 9 1 2
A:A:G45 O:O:?1 6.5 0 No Yes 9 0 1 0
A:A:D200 A:A:K46 9.68 0 No Yes 9 9 2 1
A:A:K46 O:O:?1 8.42 0 Yes Yes 9 0 1 0
A:A:S47 O:O:?1 4.89 0 No Yes 9 0 1 0
A:A:A326 A:A:T48 3.36 0 No No 9 9 2 1
A:A:T48 O:O:?1 7.2 0 No Yes 9 0 1 0
A:A:N149 A:A:N76 2.72 5 No No 6 9 2 2
A:A:N76 A:A:Y155 4.65 5 No Yes 9 7 2 2
A:A:N76 A:A:R178 6.03 5 No No 9 9 2 1
A:A:N149 A:A:R178 10.85 5 No No 6 9 2 1
A:A:D150 A:A:S151 4.42 5 Yes Yes 8 8 1 1
A:A:D150 A:A:K270 5.53 5 Yes Yes 8 9 1 1
A:A:D150 A:A:L273 2.71 5 Yes Yes 8 6 1 1
A:A:D150 O:O:?1 9.57 5 Yes Yes 8 0 1 0
A:A:S151 A:A:Y155 2.54 5 Yes Yes 8 7 1 2
A:A:R176 A:A:S151 2.64 5 Yes Yes 6 8 1 1
A:A:S151 O:O:?1 4.89 5 Yes Yes 8 0 1 0
A:A:Y154 A:A:Y155 3.97 0 Yes Yes 9 7 2 2
A:A:R176 A:A:Y154 13.38 5 Yes Yes 6 9 1 2
A:A:Q172 A:A:T327 2.83 0 No No 6 8 2 1
A:A:R176 A:A:T327 11.64 5 Yes No 6 8 1 1
A:A:R176 O:O:?1 4.61 5 Yes Yes 6 0 1 0
A:A:R178 O:O:?1 1.98 5 No Yes 9 0 1 0
A:A:A226 A:A:K270 3.21 0 No Yes 8 9 2 1
A:A:K270 A:A:S228 9.18 5 Yes No 9 9 1 2
A:A:L273 A:A:S228 6.01 5 Yes No 6 9 1 2
A:A:K270 O:O:?1 5.36 5 Yes Yes 9 0 1 0
A:A:C325 A:A:K271 4.85 5 Yes No 7 5 1 2
A:A:D272 A:A:L273 5.43 5 No Yes 9 6 1 1
A:A:C325 A:A:D272 4.67 5 Yes No 7 9 1 1
A:A:D272 O:O:?1 3.68 5 No Yes 9 0 1 0
A:A:L273 O:O:?1 2.25 5 Yes Yes 6 0 1 0
A:A:C325 A:A:D328 3.11 5 Yes No 7 9 1 2
A:A:C325 O:O:?1 3.44 5 Yes Yes 7 0 1 0
A:A:T327 O:O:?1 13.6 5 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub7.00
Average Interaction Strength5.88
Average Nodes In Shell27.00
Average Hubs In Shell11.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VUJ A Orphan Orphan GPR139 Homo Sapiens JNJ-63533054 GDP chim(Gs-CtGq)/Beta1/Gamma2 3.8 2021-12-29 10.1038/s41422-021-00591-w

A 2D representation of the interactions of GDP in 7VUJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 4.23 0 Yes No 9 8 1 2
A:A:N50 A:A:R265 3.62 0 No No 9 9 1 2
A:A:K53 A:A:S51 7.65 0 Yes No 9 9 1 2
A:A:G52 O:O:?1 4.64 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 5.53 0 No Yes 9 9 2 1
A:A:K53 O:O:?1 3.83 0 Yes Yes 9 0 1 0
A:A:D223 A:A:S54 7.36 0 No No 9 9 2 1
A:A:S54 O:O:?1 5.7 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 16.79 0 No Yes 9 0 1 0
A:A:I56 A:A:N292 9.91 0 No Yes 7 9 2 1
A:A:N292 A:A:V247 4.43 17 Yes No 9 7 1 2
A:A:D249 A:A:K293 8.3 0 No No 8 9 2 1
A:A:A366 A:A:N292 4.69 17 No Yes 9 9 1 1
A:A:N292 O:O:?1 3.72 17 Yes Yes 9 0 1 0
A:A:K293 A:A:L296 8.46 0 No No 9 6 1 2
A:A:K293 O:O:?1 22.95 0 No Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 0 No No 9 6 1 2
A:A:D295 O:O:?1 11.04 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 5.98 17 No Yes 9 0 1 0
A:A:N50 O:O:?1 1.49 0 No Yes 9 0 1 0
A:A:Q59 A:A:T55 1.42 0 No No 9 9 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.46
Average Nodes In Shell19.00
Average Hubs In Shell3.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IYS A Lipid Free Fatty Acid FFA4 Homo Sapiens TUG-891 GDP chim(NtGi1L-Gq)/Beta1/Gamma2 2.95 2023-06-21 10.1038/s41422-023-00835-x

A 2D representation of the interactions of GDP in 8IYS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K52 A:A:L44 7.05 0 Yes No 9 8 1 2
A:A:G51 O:O:?1 5.57 0 No Yes 9 0 1 0
A:A:D205 A:A:K52 8.3 0 No Yes 9 9 2 1
A:A:K52 O:O:?1 7.65 0 Yes Yes 9 0 1 0
A:A:R183 A:A:S53 3.95 11 No No 9 9 1 1
A:A:S53 O:O:?1 6.52 11 No Yes 9 0 1 0
A:A:T54 O:O:?1 7.2 0 No Yes 9 0 1 0
A:A:D155 A:A:K275 9.68 11 No Yes 8 9 1 1
A:A:D155 A:A:L278 4.07 11 No Yes 8 5 1 1
A:A:D155 O:O:?1 4.42 11 No Yes 8 0 1 0
A:A:R181 A:A:S156 9.22 8 Yes No 6 9 2 1
A:A:S156 O:O:?1 4.07 0 No Yes 9 0 1 0
A:A:R181 A:A:T332 5.17 8 Yes No 6 9 2 1
A:A:R183 O:O:?1 11.86 11 No Yes 9 0 1 0
A:A:L229 A:A:N274 4.12 2 No Yes 7 9 2 1
A:A:A231 A:A:K275 4.82 0 No Yes 8 9 2 1
A:A:K275 A:A:S233 7.65 11 Yes No 9 9 1 2
A:A:L278 A:A:S233 6.01 11 Yes No 5 9 1 2
A:A:N274 A:A:T329 4.39 0 Yes No 9 9 1 2
A:A:A331 A:A:N274 4.69 0 No Yes 9 9 2 1
A:A:N274 O:O:?1 8.19 0 Yes Yes 9 0 1 0
A:A:K275 A:A:L278 4.23 11 Yes Yes 9 5 1 1
A:A:K275 O:O:?1 20.66 11 Yes Yes 9 0 1 0
A:A:D277 A:A:L278 5.43 11 Yes Yes 9 5 1 1
A:A:C330 A:A:D277 6.22 0 No Yes 7 9 2 1
A:A:D277 O:O:?1 8.1 11 Yes Yes 9 0 1 0
A:A:L278 O:O:?1 5.26 11 Yes Yes 5 0 1 0
A:A:T332 O:O:?1 13.6 0 No Yes 9 0 1 0
A:A:S154 A:A:S156 3.26 0 No No 7 9 2 1
A:A:K52 A:A:S50 3.06 0 Yes No 9 9 1 2
A:A:D277 A:A:E281 1.3 11 Yes No 9 5 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.59
Average Nodes In Shell25.00
Average Hubs In Shell7.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JPB A Peptide Neurotensin NTS1 Homo Sapiens Neurotensin-(8-13) PubChem 118610427; GDP; Mg Gq; GRK2 3.07 2023-08-09 10.1038/s41586-023-06395-9

A 2D representation of the interactions of GDP in 8JPB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
I:I:?1 I:I:?2 9.64 10 Yes Yes 0 0 1 1
A:A:S53 I:I:?1 5.78 10 Yes Yes 9 0 1 1
A:A:T186 I:I:?1 8.51 10 No Yes 9 0 2 1
I:I:?1 O:O:?1 11.56 10 Yes Yes 0 0 1 0
A:A:G48 I:I:?2 4.64 0 No Yes 7 0 2 1
A:A:T186 I:I:?2 4 10 No Yes 9 0 2 1
I:I:?2 O:O:?1 14.26 10 Yes Yes 0 0 1 0
A:A:K52 A:A:L44 4.23 0 Yes No 9 8 1 2
A:A:G46 A:A:K52 3.49 0 No Yes 9 9 2 1
A:A:K52 A:A:S50 7.65 0 Yes No 9 9 1 2
A:A:G51 O:O:?1 7.42 0 No Yes 9 0 1 0
A:A:D205 A:A:K52 4.15 0 No Yes 9 9 2 1
A:A:G208 A:A:K52 3.49 0 No Yes 9 9 2 1
A:A:K52 O:O:?1 10.71 0 Yes Yes 9 0 1 0
A:A:S53 A:A:T186 6.4 10 Yes No 9 9 1 2
A:A:D205 A:A:S53 5.89 0 No Yes 9 9 2 1
A:A:S53 O:O:?1 6.52 10 Yes Yes 9 0 1 0
A:A:T54 O:O:?1 14.39 0 No Yes 9 0 1 0
A:A:D155 A:A:K275 6.91 10 No Yes 8 9 1 1
A:A:D155 O:O:?1 15.46 10 No Yes 8 0 1 0
A:A:R181 A:A:T332 3.88 14 Yes No 6 9 2 1
A:A:A231 A:A:K275 4.82 0 No Yes 8 9 2 1
A:A:K275 A:A:N274 5.6 10 Yes Yes 9 9 1 1
A:A:N274 A:A:T329 4.39 10 Yes No 9 9 1 2
A:A:A331 A:A:N274 4.69 0 No Yes 9 9 2 1
A:A:N274 O:O:?1 9.68 10 Yes Yes 9 0 1 0
A:A:K275 O:O:?1 18.36 10 Yes Yes 9 0 1 0
A:A:D277 A:A:L278 5.43 0 Yes No 9 5 1 2
A:A:D277 A:A:E280 3.9 0 Yes No 9 5 1 2
A:A:C330 A:A:D277 4.67 18 Yes Yes 7 9 2 1
A:A:D277 O:O:?1 8.1 0 Yes Yes 9 0 1 0
A:A:T332 O:O:?1 16.79 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength12.11
Average Nodes In Shell26.00
Average Hubs In Shell10.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JPC A Peptide Neurotensin NTS1 Homo Sapiens Neurotensin-(8-13) PubChem 118610427; GDP; Mg Gq; GRK2 3.07 2023-08-09 10.1038/s41586-023-06395-9

A 2D representation of the interactions of GDP in 8JPC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K52 A:A:L44 4.23 0 Yes No 9 8 1 2
A:A:G46 A:A:K52 3.49 0 No Yes 9 9 2 1
A:A:G48 I:I:?2 4.64 0 No Yes 7 0 2 1
A:A:E49 A:A:R183 6.98 0 No Yes 9 9 2 1
A:A:K52 A:A:S50 7.65 0 Yes No 9 9 1 2
A:A:G51 O:O:?1 7.42 0 No Yes 9 0 1 0
A:A:D205 A:A:K52 4.15 0 No Yes 9 9 2 1
A:A:G208 A:A:K52 3.49 0 No Yes 9 9 2 1
A:A:K52 O:O:?1 10.71 0 Yes Yes 9 0 1 0
A:A:S53 A:A:T186 4.8 9 Yes No 9 9 1 2
A:A:D205 A:A:S53 5.89 0 No Yes 9 9 2 1
A:A:S53 I:I:?1 5.78 9 Yes Yes 9 0 1 1
A:A:S53 O:O:?1 6.52 9 Yes Yes 9 0 1 0
A:A:T54 O:O:?1 14.39 0 No Yes 9 0 1 0
A:A:D155 A:A:K275 6.91 9 No Yes 8 9 1 1
A:A:D155 O:O:?1 15.46 9 No Yes 8 0 1 0
A:A:R181 A:A:T332 3.88 11 Yes No 6 9 2 1
A:A:P185 A:A:R183 7.21 0 No Yes 7 9 2 1
A:A:R183 I:I:?2 6.59 9 Yes Yes 9 0 1 1
A:A:R183 O:O:?1 8.57 9 Yes Yes 9 0 1 0
A:A:T186 I:I:?2 4 9 No Yes 9 0 2 1
A:A:T186 I:I:?1 8.51 9 No Yes 9 0 2 1
A:A:A231 A:A:K275 4.82 0 No Yes 8 9 2 1
A:A:K275 A:A:N274 5.6 9 Yes Yes 9 9 1 1
A:A:N274 A:A:T329 4.39 9 Yes No 9 9 1 2
A:A:A331 A:A:N274 4.69 0 No Yes 9 9 2 1
A:A:N274 O:O:?1 9.68 9 Yes Yes 9 0 1 0
A:A:K275 O:O:?1 18.36 9 Yes Yes 9 0 1 0
A:A:D277 A:A:L278 5.43 0 Yes No 9 5 1 2
A:A:D277 A:A:E280 3.9 0 Yes No 9 5 1 2
A:A:C330 A:A:D277 4.67 20 Yes Yes 7 9 2 1
A:A:D277 O:O:?1 8.1 0 Yes Yes 9 0 1 0
A:A:T332 O:O:?1 16.79 0 No Yes 9 0 1 0
I:I:?1 I:I:?2 9.64 9 Yes Yes 0 0 1 1
I:I:?2 O:O:?1 13.58 9 Yes Yes 0 0 1 0
I:I:?1 O:O:?1 11.56 9 Yes Yes 0 0 1 0
A:A:R183 A:A:S154 2.64 9 Yes No 9 7 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub8.00
Average Interaction Strength11.76
Average Nodes In Shell30.00
Average Hubs In Shell11.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.88
Average Number Of Links With An Hub4.62
Average Interaction Strength8.81
Average Nodes In Shell24.25
Average Hubs In Shell7.50
Average Links In Shell30.25
Average Links Mediated by Hubs In Shell25.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)