Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L37 3.57449
2A:A:L38 3.99508
3A:A:K46 6.3475409
4A:A:Q52 5.8825489
5A:A:M53 8.9475488
6A:A:I56 4.44487
7A:A:H57 10.56588
8A:A:Y61 7.434187
9A:A:I81 3.2875406
10A:A:F95 6.788504
11A:A:D97 5.3975402
12A:A:R100 6.425405
13A:A:M119 3.625403
14A:A:L123 3.5475403
15A:A:W131 7.8625408
16A:A:D133 6.195408
17A:A:Y146 5.8675406
18A:A:D150 5.5575458
19A:A:S151 3.6225458
20A:A:Y154 6.6375409
21A:A:Y155 4.16333607
22A:A:R161 5.14754118
23A:A:Y167 8.055118
24A:A:I168 3.09754113
25A:A:P169 5.2785119
26A:A:D173 5.3345119
27A:A:R176 8.0675456
28A:A:F189 6.79589
29A:A:F191 8.482585
30A:A:F196 7.285487
31A:A:F199 4.415405
32A:A:V201 3.7449
33A:A:K210 4.805409
34A:A:W211 3.756549
35A:A:H213 5.825468
36A:A:I221 4.84408
37A:A:F223 3.475649
38A:A:Y230 5.533336148
39A:A:D231 5.2654149
40A:A:M247 4.6925406
41A:A:I253 4.0225448
42A:A:W258 6.946565
43A:A:I265 3.3045108
44A:A:L266 4.3175409
45A:A:F267 3.5945109
46A:A:K270 5.82459
47A:A:L273 4.1456
48A:A:F274 4.568509
49A:A:S281 3.844147
50A:A:Y287 4.04407
51A:A:Y290 8.665407
52A:A:Y302 13.745406
53A:A:F307 6.735408
54A:A:E308 4.24403
55A:A:C325 4.0175457
56A:A:F336 5.51833688
57B:B:L14 6.155408
58B:B:R48 5.775417
59B:B:H54 9.208519
60B:B:Y59 8.0925468
61B:B:W63 4.69143717
62B:B:R68 10.69415
63B:B:D76 4.5825419
64B:B:I80 7.945418
65B:B:W82 7.72719
66B:B:Y85 9.6675414
67B:B:K89 5.37833619
68B:B:H91 4.595415
69B:B:I93 5.8975407
70B:B:W99 6.22429709
71B:B:Y105 3.07286716
72B:B:N110 4.80754224
73B:B:Y111 3.1675404
74B:B:C114 3.81754218
75B:B:Y124 5.275406
76B:B:H142 6.265699
77B:B:Y145 3.27143748
78B:B:R150 3.10754126
79B:B:F151 3.832509
80B:B:N155 5.005403
81B:B:D163 8.48499
82B:B:W169 8.566598
83B:B:F180 6.8325127
84B:B:H183 4.8025239
85B:B:L190 3.295125
86B:B:L192 3.3725405
87B:B:F199 5.6785129
88B:B:D205 6.184239
89B:B:W211 8.5925128
90B:B:R214 2.3654259
91B:B:F222 5.6075428
92B:B:H225 8.212529
93B:B:I232 3.506528
94B:B:F234 4.2754245
95B:B:F235 5.71636
96B:B:F241 4.94571726
97B:B:T243 4.7225428
98B:B:D247 5.43429
99B:B:C250 2.8425408
100B:B:R251 7.75167628
101B:B:F253 6.654526
102B:B:D254 2.9925409
103B:B:Y264 3.64667635
104B:B:C271 4.014535
105B:B:F278 6.3025437
106B:B:K280 5.145411
107B:B:R283 6.616676209
108B:B:L285 3.9825436
109B:B:Y289 5.60833637
110B:B:N293 7.335435
111B:B:N295 5.728536
112B:B:W297 3.875438
113B:B:L300 3.335206
114B:B:V307 3.1433
115B:B:H311 7.3245269
116B:B:M325 2.99415
117B:B:W332 11.215669
118B:B:D333 6.524269
119B:B:L336 3.07417
120B:B:W339 8.296509
121B:B:N340 5.1175419
122G:G:R27 6.206528
123G:G:H44 3.915406
124G:G:D48 5.508519
125G:G:N59 6.0475419
126G:G:P60 5.9975419
127G:G:F61 3.6911018
128O:O:?1 5.876151350
129R:R:Y27 8.1165275
130R:R:F30 9.8454272
131R:R:V43 3.9654166
132R:R:L47 5.9054167
133R:R:T54 4.1075407
134R:R:Y58 7.3525404
135R:R:D67 4.48254287
136R:R:Y69 14.786577
137R:R:I80 6.945407
138R:R:L84 7.8675408
139R:R:Y111 12.1854175
140R:R:F115 6.0475407
141R:R:F120 13.7483678
142R:R:L124 7.546579
143R:R:R128 5.29479
144R:R:N143 2.1475406
145R:R:N197 7.124296
146R:R:Y222 5.138504
147R:R:L231 3.7075406
148R:R:V237 2.33408
149R:R:F241 6.115409
150R:R:W245 4.605409
151R:R:N249 6.7225409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L69 B:B:Y105 92.03162.34NoYes156
2B:B:L69 B:B:R68 91.91752.43NoYes155
3B:B:D83 B:B:R68 31.214413.1NoYes085
4B:B:D83 B:B:T86 31.11968.67NoNo086
5B:B:N88 B:B:T86 31.02948.77NoNo076
6A:A:S16 B:B:N88 30.86362.98NoNo077
7A:A:S16 B:B:K89 30.82273.06NoYes079
8A:A:L23 B:B:I80 77.51532.85NoYes068
9B:B:I80 B:B:K89 30.41632.91YesYes189
10A:A:L23 B:B:L55 76.952.77NoNo066
11B:B:L70 B:B:W82 45.17166.83NoYes159
12B:B:G162 B:B:Y145 98.13674.35NoYes098
13B:B:G162 B:B:S161 98.28541.86NoNo099
14B:B:H142 B:B:S161 98.25816.74YesNo999
15B:B:H142 B:B:T159 49.55455.48YesNo999
16B:B:T159 B:B:W169 49.79329.7NoYes998
17B:B:I157 B:B:W169 99.53413.52NoYes078
18B:B:F151 B:B:I157 98.84118.79YesNo097
19B:B:F151 B:B:Y111 98.9662.06YesYes094
20B:B:N110 B:B:Y111 99.91733.49YesYes044
21B:B:N110 B:B:S108 99.87777.45YesNo2246
22B:B:G109 B:B:S108 99.98371.86NoNo056
23B:B:G109 B:B:Y105 1002.9NoYes056
24B:B:H142 B:B:Q176 49.59032.47YesNo994
25B:B:Q176 B:B:W169 49.610312.05NoYes948
26A:A:K46 A:A:L38 11.3254.23YesYes098
27A:A:K46 A:A:S44 59.58083.06YesNo099
28A:A:G40 A:A:S44 59.75481.86NoNo099
29A:A:F223 A:A:G40 59.92983.01YesNo099
30A:A:F223 A:A:I253 84.02713.77YesYes498
31A:A:I253 A:A:R208 84.33773.76YesNo489
32A:A:R208 A:A:W211 84.68844NoYes499
33A:A:W211 B:B:Y145 85.64272.89YesYes498
34A:A:K270 O:O:?1 13.51625.36YesYes590
35A:A:K46 O:O:?1 49.05088.42YesYes090
36A:A:D173 A:A:Y154 14.04934.6YesYes099
37A:A:R176 A:A:Y154 14.746613.38YesYes069
38A:A:R176 O:O:?1 14.87294.61YesYes560
39A:A:D173 A:A:Y167 11.98428.05YesYes1198
40A:A:Y167 A:A:Y74 11.61025.96YesNo084
41A:A:M119 A:A:Y74 11.43395.99YesNo034
42A:A:L148 A:A:Y146 10.42444.69NoYes076
43A:A:R144 A:A:Y146 12.41198.23NoYes066
44A:A:D231 A:A:R144 12.81132.38YesNo096
45A:A:D231 A:A:K277 15.35642.77YesNo1499
46A:A:K277 A:A:S228 23.2264.59NoNo099
47A:A:K270 A:A:S228 11.81839.18YesNo099
48A:A:L273 A:A:S228 11.81036.01YesNo069
49A:A:L273 O:O:?1 11.88942.25YesYes560
50A:A:L123 A:A:M119 10.06114.24YesYes033
51A:A:F223 A:A:L266 10.0033.65YesYes099
52A:A:L283 A:A:Y230 10.75083.52NoYes078
53A:A:L283 A:A:Y290 11.29612.34NoYes077
54A:A:Y290 A:A:Y302 15.112322.84YesYes076
55A:A:Y287 A:A:Y302 17.33163.97YesYes076
56A:A:M247 A:A:Y287 19.068.38YesYes067
57A:A:F307 A:A:M247 22.01983.73YesYes086
58B:B:H62 B:B:Y105 30.94663.27NoYes066
59B:B:H62 B:B:R150 30.81983.39NoYes066
60B:B:L190 B:B:R150 15.81362.43YesYes1256
61B:B:F199 B:B:L190 13.86054.87YesYes1295
62B:B:F199 B:B:W211 12.903612.03YesYes1298
63B:B:L192 B:B:R150 14.46412.43YesYes056
64B:B:F199 B:B:L192 13.84262.44YesYes095
65B:B:R68 B:B:Y85 60.970423.66YesYes154
66B:B:M325 G:G:P49 25.70683.35YesNo157
67G:G:D48 G:G:P49 24.56523.22YesNo197
68G:G:D48 G:G:L51 12.0664.07YesNo096
69B:B:R283 G:G:L51 11.3242.43YesNo096
70B:B:L300 B:B:R283 15.02116.07YesYes2069
71B:B:L300 B:B:T34 13.82574.42YesNo065
72B:B:L30 B:B:T34 12.63325.9NoNo055
73B:B:Y85 G:G:F61 15.39114.13YesYes148
74B:B:M325 G:G:F61 15.90872.49YesYes158
75B:B:N340 G:G:F61 10.98264.83YesYes198
76B:B:M45 B:B:N340 10.98512.8NoYes049
77B:B:L70 B:B:W63 42.46336.83NoYes157
78B:B:L55 R:R:E137 76.52826.63NoNo065
79B:B:S84 B:B:Y85 37.48872.54NoYes154
80B:B:F199 B:B:V213 13.08332.62YesNo094
81B:B:R214 B:B:V213 12.82332.62YesNo094
82B:B:L210 B:B:L255 10.05424.15NoNo056
83B:B:S281 G:G:D48 12.18858.83NoYes099
84B:B:S281 G:G:H44 11.89832.79NoYes096
85G:G:H44 G:G:Y40 10.47248.71YesNo066
86R:R:E137 R:R:L138 76.31729.28NoNo055
87R:R:L138 R:R:R140 75.89463.64NoNo054
88R:R:N143 R:R:R140 75.68312.41YesNo064
89R:R:N143 R:R:P65 73.98663.26YesNo067
90R:R:D127 R:R:P65 70.56831.61NoNo087
91R:R:D127 R:R:R128 69.88458.34NoYes789
92R:R:L124 R:R:R128 60.78963.64YesYes799
93R:R:F120 R:R:L124 49.24414.87YesYes789
94R:R:F120 R:R:L121 37.93459.74YesNo788
95R:R:F241 R:R:L121 37.73394.87YesNo098
96R:R:F241 R:R:W245 26.31456.01YesYes099
97R:R:F244 R:R:W245 10.57955.01NoYes089
98R:R:F244 R:R:L282 20.63093.65NoNo087
99R:R:L282 R:R:V278 19.1992.98NoNo075
100R:R:V278 R:R:Y277 28.13195.05NoNo055
101R:R:F30 R:R:Y277 27.413112.38YesNo025
102R:R:F30 R:R:Y27 24.53426.19YesYes2725
103R:R:F241 R:R:R286 10.771810.69YesNo099
104R:R:F244 R:R:R286 10.566316.03NoNo089
105R:R:F248 R:R:W245 11.04794.01NoYes079
106R:R:L88 R:R:Y27 10.84362.34NoYes075
107R:R:Y27 R:R:Y284 10.843617.87YesNo057
108R:R:E31 R:R:L88 10.12169.28NoNo047
109R:R:I70 R:R:Y69 15.06089.67NoYes787
110R:R:I70 R:R:Y294 22.25453.63NoNo089
111R:R:M301 R:R:Y294 21.53954.79NoNo099
112R:R:M301 R:R:V51 11.50244.56NoNo099
113R:R:P291 R:R:V51 10.06643.53NoNo099
114R:R:L84 R:R:Y284 10.121621.1YesNo087
115B:B:S84 B:B:W63 41.85383.71NoYes157
116B:B:I80 B:B:W82 48.148714.09YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7RKY
Class A
SubFamily Other
Type Unclassified
SubType US27
Species Human Betaherpesvirus 5
Ligand -
Other Ligand(s) GDP
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.8
Date 2022-01-26
D.O.I. doi.org/10.1126/sciadv.abl5442
Net Summary
Imin 1.86
Number of Linked Nodes 926
Number of Links 1078
Number of Hubs 151
Number of Links mediated by Hubs 568
Number of Communities 29
Number of Nodes involved in Communities 212
Number of Links involved in Communities 293
Path Summary
Number Of Nodes in MetaPath 117
Number Of Links MetaPath 116
Number of Shortest Paths 2280682
Length Of Smallest Path 3
Average Path Length 38.0462
Length of Longest Path 76
Minimum Path Strength 1.275
Average Path Strength 5.36092
Maximum Path Strength 28.96
Minimum Path Correlation 0.7
Average Path Correlation 0.99108
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.04082
Average % Of Corr. Nodes 39.8398
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.9078
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • molecular transducer activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • C-C chemokine binding   • chemokine binding   • cytokine binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell chemotaxis   • chemotaxis   • response to external stimulus   • taxis   • cell migration   • cell motility   • locomotion   • calcium-mediated signaling   • immune response   • immune system process   • virion component   • host cell plasma membrane   • host cellular component   • host cell part   • host cell membrane
SCOP2Domain Identifier• Galpha insert domain-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Galpha insert domain-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeGDP
PDB ResiduesO:O:?1
Environment DetailsOpen EMBL-EBI Page
CodeGDP
NameGuanosine-5'-Diphosphate
SynonymsGuanosine-5'-Diphosphate
Identifier
FormulaC10 H15 N5 O11 P2
Molecular Weight443.201
SMILES
PubChem135398619
Formal Charge0
Total Atoms43
Total Chiral Atoms4
Total Bonds45
Total Aromatic Bonds5

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7RKY_Chain_A
GCTLSAEDK AAVERSKMI DRNLREDGE KAAREVKLL LLGAGESGK 
STIVKQMKI IHEAGYSEE ECKQYKAVV YSNTIQSII AIIRAMGRL 
KIDFGDSAR ADDARQLFV LAGAAEEGF MTAELAGVI KRLWKDSGV 
QACFNRSRE YQLNDSAAY YLNDLDRIA QPNYIPTQQ DVLRTRVKT 
TGIVETHFT FKDLHFKMF DVGGQRSER KKWIHCFEG VTAIIFCVA 
LSDYDLVNR MHESMKLFD SICNNKWFT DTSIILFLN KKDLFEEKI 
KKSPLTICY PEYAGSNTY EEAAAYIQC QFEDLNKRK DTKEIYTHF 
TCATDTKNV QFVFDAVTD VIIKNNLK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7RKY_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7RKY_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP09703
Sequence
>7RKY_Chain_R
EIYQLFEYT RLGVWLMCI VGTFLNVLV ITTILYYRR KKKSPSDTY 
ICNLAVADL LIVVGLPFF LEYAKHHPS REVVCSGLN ACFYICLFA 
GVCFLINLS MDRYCVIVW GVELNRVRN NKRATCWVV IFWILAVLM 
GMPHYVFLN TKVNICGYL APIALMAYT YNRMVRFII NYVGKWHMQ 
TLHVLLVVV VSFASFWFP FNLALFLES IDTLQNVII FCLYVGQFL 
AYVRACLNP GIYILVGTQ MRKDMWTTL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RKYAOtherUnclassifiedUS27Human betaherpesvirus 5-GDPGi1/β1/γ23.82022-01-26doi.org/10.1126/sciadv.abl5442
7RKY (No Gprot) AOtherUnclassifiedUS27Human betaherpesvirus 5-GDP3.82022-01-26doi.org/10.1126/sciadv.abl5442
7RKXAOtherUnclassifiedUS27Human betaherpesvirus 5--Gi1/β1/γ23.12022-01-2610.1126/sciadv.abl5442
7RKX (No Gprot) AOtherUnclassifiedUS27Human betaherpesvirus 5--3.12022-01-2610.1126/sciadv.abl5442




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