psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L21	R:R:T20	2.95	Yes	No	0	3	4
2	R:R:E31	R:R:T20	4.23	Yes	No	0	4	4
3	R:R:L21	R:R:S23	3	Yes	No	0	3	5
4	R:R:L21	R:R:T24	4.42	Yes	Yes	0	3	4
5	R:R:L21	R:R:V102	2.98	Yes	No	0	3	5
6	R:R:R99	R:R:S23	10.54	No	No	0	7	5
7	R:R:I26	R:R:T24	6.08	No	Yes	0	1	4
8	R:R:H171	R:R:T24	2.74	No	Yes	0	4	4
9	R:R:C176	R:R:T24	3.38	No	Yes	0	9	4
10	R:R:E25	R:R:Q28	10.19	No	No	0	4	4
11	R:R:E179	R:R:I26	5.47	Yes	No	2	3	1
12	R:R:I26	R:R:L276	2.85	No	Yes	2	1	4
13	R:R:F30	R:R:Y27	14.44	No	No	0	2	5
14	R:R:E31	R:R:Y27	8.98	Yes	No	0	4	5
15	R:R:Q280	R:R:Y27	10.15	Yes	No	0	5	5
16	R:R:Q28	R:R:Y32	14.65	No	No	0	4	4
17	R:R:L29	R:R:T33	2.95	No	No	0	3	5
18	R:R:F281	R:R:F30	4.29	No	No	0	6	2
19	R:R:E31	R:R:R34	19.77	Yes	No	4	4	4
20	R:R:E31	R:R:L88	13.25	Yes	No	4	4	7
21	R:R:L88	R:R:R34	8.5	No	No	4	7	4
22	R:R:V37	R:R:Y284	7.57	No	Yes	0	7	7
23	R:R:E89	R:R:W38	8.72	No	No	0	5	3
24	R:R:I42	R:R:L39	2.85	No	No	0	4	5
25	R:R:M40	R:R:Y284	7.18	No	Yes	5	7	7
26	R:R:C288	R:R:M40	6.48	No	No	5	8	7
27	R:R:C41	R:R:V81	5.12	No	No	0	7	6
28	R:R:F46	R:R:I42	8.79	No	No	0	4	4
29	R:R:G44	R:R:L47	3.42	No	No	0	9	7
30	R:R:L78	R:R:T45	5.9	No	No	0	8	5
31	R:R:N48	R:R:P291	6.52	No	No	0	9	9
32	R:R:L309	R:R:L50	6.92	No	No	0	5	6
33	R:R:M305	R:R:V51	3.04	No	No	0	6	9
34	R:R:A74	R:R:I52	3.25	No	No	0	8	7
35	R:R:D304	R:R:T54	4.34	Yes	No	3	5	7
36	R:R:M305	R:R:T54	7.53	No	No	0	6	7
37	R:R:T308	R:R:T54	12.56	Yes	No	3	5	7
38	R:R:D67	R:R:I55	9.8	Yes	No	0	7	7
39	R:R:C71	R:R:I55	3.27	No	No	0	6	7
40	R:R:I55	R:R:M301	2.92	No	No	0	7	9
41	R:R:L56	R:R:R60	4.86	No	No	0	4	5
42	R:R:Y57	R:R:Y58	7.94	No	No	0	4	4
43	R:R:D304	R:R:Y58	8.05	Yes	No	3	5	4
44	R:R:T308	R:R:Y58	12.48	Yes	No	3	5	4
45	R:R:K63	R:R:R59	6.19	No	No	0	5	4
46	R:R:K63	R:R:R60	3.71	No	No	0	5	5
47	R:R:K61	R:R:M301	7.2	No	No	0	5	9
48	R:R:D304	R:R:K61	4.15	Yes	No	0	5	5
49	R:R:D67	R:R:S64	4.42	Yes	No	0	7	7
50	R:R:D127	R:R:P65	3.22	No	No	0	8	7
51	R:R:D127	R:R:S66	5.89	No	No	0	8	8
52	R:R:R128	R:R:S66	5.27	No	No	0	9	8
53	R:R:D67	R:R:T68	2.89	Yes	No	0	7	7
54	R:R:D67	R:R:I70	2.8	Yes	No	0	7	8
55	R:R:T68	R:R:Y69	6.24	No	Yes	0	7	7
56	R:R:N123	R:R:Y69	22.1	No	Yes	0	7	7
57	R:R:D127	R:R:Y69	4.6	No	Yes	0	8	7
58	R:R:I70	R:R:Y294	12.09	No	No	0	8	9
59	R:R:F120	R:R:N72	13.29	No	No	6	8	9
60	R:R:N72	R:R:V151	2.96	No	No	0	9	7
61	R:R:N72	R:R:W155	4.52	No	Yes	6	9	9
62	R:R:A287	R:R:D77	3.09	No	No	0	9	9
63	R:R:D77	R:R:N290	5.39	No	Yes	0	9	9
64	R:R:C109	R:R:L79	3.17	No	No	0	4	6
65	R:R:I80	R:R:L84	2.85	No	No	0	7	8
66	R:R:C113	R:R:I80	6.55	No	No	0	8	7
67	R:R:A287	R:R:I80	4.87	No	No	0	9	7
68	R:R:L84	R:R:Q280	3.99	No	Yes	0	8	5
69	R:R:F86	R:R:F87	5.36	No	No	0	7	6
70	R:R:E89	R:R:K92	5.4	No	No	0	5	4
71	R:R:H94	R:R:Y90	14.16	No	No	0	5	5
72	R:R:L97	R:R:Y90	7.03	No	No	0	3	5
73	R:R:L97	R:R:V102	2.98	No	No	0	3	5
74	R:R:E100	R:R:R99	8.14	No	No	0	2	7
75	R:R:H171	R:R:R99	13.54	No	No	0	4	7
76	R:R:E100	R:R:S170	4.31	No	No	0	2	3
77	R:R:C103	R:R:N107	6.3	No	No	0	9	7
78	R:R:C103	R:R:C176	7.28	No	No	0	9	9
79	R:R:L167	R:R:S104	9.01	No	No	0	5	8
80	R:R:S104	R:R:S170	3.26	No	No	0	8	3
81	R:R:N107	R:R:N174	9.54	No	No	0	7	4
82	R:R:A108	R:R:Y166	4	No	No	0	6	4
83	R:R:F110	R:R:Y111	3.09	No	Yes	0	7	5
84	R:R:F110	R:R:W245	4.01	No	Yes	0	7	9
85	R:R:F110	R:R:Q280	5.86	No	Yes	0	7	5
86	R:R:H165	R:R:Y111	15.24	Yes	Yes	1	4	5
87	R:R:N174	R:R:Y111	4.65	No	Yes	1	4	5
88	R:R:E175	R:R:Y111	8.98	No	Yes	0	3	5
89	R:R:L114	R:R:W245	4.56	No	Yes	0	8	9
90	R:R:F115	R:R:M161	4.98	No	No	0	7	5
91	R:R:F115	R:R:G162	3.01	No	No	1	7	7
92	R:R:F115	R:R:H165	4.53	No	Yes	1	7	4
93	R:R:P204	R:R:V118	7.07	Yes	No	0	9	8
94	R:R:F120	R:R:W155	10.02	No	Yes	6	8	9
95	R:R:L121	R:R:V237	2.98	No	No	0	8	8
96	R:R:F241	R:R:L121	3.65	No	No	0	9	8
97	R:R:I122	R:R:L207	5.71	No	No	0	8	6
98	R:R:F154	R:R:N123	10.87	No	No	0	7	7
99	R:R:L124	R:R:L234	2.77	No	No	0	9	7
100	R:R:S125	R:R:T211	4.8	No	Yes	0	9	8
101	R:R:R128	R:R:T230	5.17	No	No	0	9	8
102	R:R:V133	R:R:Y129	10.09	No	No	0	7	8
103	R:R:T211	R:R:Y129	4.99	Yes	No	7	8	8
104	R:R:M215	R:R:Y129	4.79	Yes	No	7	8	8
105	R:R:I132	R:R:V133	3.07	No	No	0	8	7
106	R:R:I132	R:R:M215	5.83	No	Yes	0	8	8
107	R:R:F218	R:R:V133	3.93	No	No	0	5	7
108	R:R:T148	R:R:V151	9.52	No	No	0	4	7
109	R:R:I156	R:R:V152	3.07	No	No	0	4	3
110	R:R:F154	R:R:I153	5.02	No	No	0	7	4
111	R:R:L160	R:R:M163	12.72	No	No	0	3	3
112	R:R:K195	R:R:M161	4.32	No	No	0	4	5
113	R:R:G162	R:R:H165	4.77	No	Yes	1	7	4
114	R:R:F188	R:R:P164	2.89	Yes	No	1	3	8
115	R:R:L192	R:R:P164	4.93	No	No	1	4	8
116	R:R:H165	R:R:N174	3.83	Yes	No	1	4	4
117	R:R:H165	R:R:L192	11.57	Yes	No	1	4	4
118	R:R:H165	R:R:V196	2.77	Yes	No	0	4	7
119	R:R:L167	R:R:Y166	3.52	No	No	0	5	4
120	R:R:M168	R:R:Y169	7.18	No	No	0	5	5
121	R:R:F188	R:R:M168	6.22	Yes	No	0	3	5
122	R:R:N173	R:R:Y169	10.47	No	No	0	3	5
123	R:R:F188	R:R:N173	14.5	Yes	No	1	3	3
124	R:R:N173	R:R:P189	8.15	No	Yes	1	3	4
125	R:R:E175	R:R:F180	3.5	No	Yes	0	3	5
126	R:R:Q280	R:R:V177	4.3	Yes	No	0	5	3
127	R:R:G178	R:R:L276	5.13	No	Yes	0	4	4
128	R:R:E179	R:R:E255	3.81	Yes	No	2	3	5
129	R:R:E179	R:R:I272	5.47	Yes	Yes	2	3	5
130	R:R:E179	R:R:L276	7.95	Yes	Yes	2	3	4
131	R:R:A181	R:R:F180	4.16	No	Yes	0	4	5
132	R:R:F180	R:R:P189	5.78	Yes	Yes	0	5	4
133	R:R:E255	R:R:F180	7	No	Yes	0	5	5
134	R:R:E183	R:R:N182	5.26	No	No	0	2	2
135	R:R:G186	R:R:P189	4.06	No	Yes	0	4	4
136	R:R:F188	R:R:P189	2.89	Yes	Yes	1	3	4
137	R:R:F188	R:R:L192	3.65	Yes	No	1	3	4
138	R:R:L260	R:R:V190	7.45	No	No	0	1	3
139	R:R:N193	R:R:N197	2.72	No	No	0	5	6
140	R:R:L252	R:R:N193	20.6	No	No	0	6	5
141	R:R:N193	R:R:S256	11.92	No	No	0	5	6
142	R:R:K195	R:R:V196	4.55	No	No	0	4	7
143	R:R:N197	R:R:N249	4.09	No	No	0	6	9
144	R:R:F253	R:R:N197	4.83	No	No	0	6	6
145	R:R:C199	R:R:I198	6.55	No	No	0	5	4
146	R:R:I198	R:R:L202	4.28	No	No	0	4	5
147	R:R:F246	R:R:Y201	4.13	No	No	0	5	9
148	R:R:N249	R:R:Y201	9.3	No	No	0	9	9
149	R:R:F241	R:R:P204	7.22	No	Yes	0	9	9
150	R:R:A242	R:R:I205	3.25	No	No	0	6	6
151	R:R:M208	R:R:V238	7.61	No	No	0	8	8
152	R:R:R214	R:R:Y210	14.4	No	No	0	3	4
153	R:R:M215	R:R:T211	3.01	Yes	Yes	7	8	8
154	R:R:V216	R:R:Y212	5.05	Yes	No	8	5	9
155	R:R:L231	R:R:Y212	4.69	No	No	8	6	9
156	R:R:L235	R:R:Y212	8.21	No	No	0	4	9
157	R:R:N213	R:R:R217	10.85	No	No	0	3	3
158	R:R:L231	R:R:V216	2.98	No	Yes	8	6	5
159	R:R:I219	R:R:M228	2.92	No	No	0	8	4
160	R:R:I220	R:R:W226	5.87	No	No	0	4	3
161	R:R:K225	R:R:M228	11.52	No	No	0	3	4
162	R:R:Q229	R:R:T299	5.67	No	No	0	7	6
163	R:R:I293	R:R:V236	10.75	No	No	0	8	6
164	R:R:F241	R:R:W245	6.01	No	Yes	0	9	9
165	R:R:F244	R:R:R286	12.83	No	No	0	8	9
166	R:R:A283	R:R:W245	3.89	No	Yes	0	8	9
167	R:R:R286	R:R:W245	11	No	Yes	0	9	9
168	R:R:F246	R:R:P247	5.78	No	No	0	5	9
169	R:R:F246	R:R:L250	3.65	No	No	0	5	5
170	R:R:L250	R:R:L254	2.77	No	No	0	5	5
171	R:R:C275	R:R:L250	6.35	No	No	0	5	5
172	R:R:A251	R:R:C275	3.61	No	No	0	5	5
173	R:R:F253	R:R:I257	12.56	No	No	0	6	4
174	R:R:L254	R:R:V271	7.45	No	No	0	5	3
175	R:R:I272	R:R:L254	2.85	Yes	No	0	5	5
176	R:R:E255	R:R:I272	6.83	No	Yes	2	5	5
177	R:R:L260	R:R:S256	4.5	No	No	0	1	6
178	R:R:R258	R:R:T267	5.17	No	No	0	3	1
179	R:R:L268	R:R:R258	3.64	No	No	0	3	3
180	R:R:G262	R:R:Y264	4.35	No	No	0	1	2
181	R:R:N265	R:R:Q269	5.28	No	No	0	5	3
182	R:R:I272	R:R:L268	2.85	Yes	No	0	5	3
183	R:R:N270	R:R:V271	4.43	No	No	0	2	3
184	R:R:I273	R:R:Y277	15.71	No	No	0	4	5
185	R:R:L276	R:R:Y277	4.69	Yes	No	0	4	5
186	R:R:F281	R:R:V285	3.93	No	No	0	6	5
187	R:R:C288	R:R:Y284	6.72	No	Yes	5	8	7
188	R:R:N290	R:R:R286	9.64	Yes	No	0	9	9
189	R:R:N290	R:R:P291	3.26	Yes	No	0	9	9
190	R:R:I293	R:R:N290	2.83	No	Yes	0	8	9
191	R:R:I293	R:R:Y294	4.84	No	No	0	8	9
192	R:R:I295	R:R:M305	4.37	No	No	0	8	6
193	R:R:L296	R:R:V297	2.98	No	No	0	8	7
194	R:R:K303	R:R:R302	7.43	No	No	0	4	8
195	R:R:R302	R:R:W306	7	No	No	0	8	2
196	R:R:K303	R:R:T307	3	No	No	0	4	4
197	R:R:D304	R:R:T308	4.34	Yes	Yes	3	5	5
198	R:R:L309	R:R:T308	2.95	No	Yes	0	5	5
199	R:R:D77	R:R:L73	2.71	No	No	0	9	9
200	R:R:P85	R:R:W38	2.7	No	No	0	9	3
201	R:R:C41	R:R:Y284	2.69	No	Yes	0	7	7
202	R:R:L29	R:R:Q28	2.66	No	No	0	3	4
203	R:R:F244	R:R:S240	2.64	No	No	0	8	6
204	R:R:R34	R:R:V37	2.62	No	No	0	4	7
205	R:R:H227	R:R:K225	2.62	No	No	0	7	3
206	R:R:F30	R:R:T33	2.59	No	No	0	2	5
207	R:R:F46	R:R:T45	2.59	No	No	0	4	5
208	R:R:A116	R:R:W155	2.59	No	Yes	0	7	9
209	R:R:V151	R:R:Y69	2.52	No	Yes	0	7	7
210	R:R:I295	R:R:R302	2.51	No	No	0	8	8
211	R:R:T172	R:R:Y169	2.5	No	No	0	1	5
212	R:R:M215	R:R:R128	2.48	Yes	No	0	8	9
213	R:R:V216	R:R:W226	2.45	Yes	No	0	5	3
214	R:R:F180	R:R:L259	2.44	Yes	No	0	5	3
215	R:R:F248	R:R:N249	2.42	No	No	0	7	9
216	R:R:D67	R:R:R60	2.38	Yes	No	0	7	5
217	R:R:R258	R:R:Y264	2.06	No	No	0	3	2
218	R:R:G279	R:R:P247	2.03	No	No	0	7	9
219	R:R:C288	R:R:G44	1.96	No	No	0	8	9
220	R:R:A116	R:R:G117	1.95	No	No	0	7	9
221	R:R:A261	R:R:G262	1.95	No	No	0	1	1
222	R:R:C41	R:R:P85	1.88	No	No	0	7	9
223	R:R:A203	R:R:P204	1.87	No	Yes	0	6	9
224	R:R:G105	R:R:S104	1.86	No	No	0	4	8
225	R:R:G224	R:R:V223	1.84	No	No	0	3	3
226	R:R:G298	R:R:V297	1.84	No	No	0	8	7
227	R:R:A76	R:R:C113	1.81	No	No	0	9	8
228	R:R:A158	R:R:C119	1.81	No	No	0	7	6
229	R:R:G224	R:R:I220	1.76	No	No	0	3	4
230	R:R:M163	R:R:P164	1.68	No	No	0	3	8
231	R:R:M208	R:R:P204	1.68	No	Yes	0	8	9
232	R:R:C71	R:R:I52	1.64	No	No	0	6	7
233	R:R:L282	R:R:P247	1.64	No	No	0	7	9
234	R:R:C130	R:R:M126	1.62	No	No	0	5	5
235	R:R:S243	R:R:V239	1.62	No	No	0	4	5
236	R:R:V81	R:R:V82	1.6	No	No	0	6	5
237	R:R:S256	R:R:T194	1.6	No	No	0	6	4
238	R:R:V233	R:R:V237	1.6	No	No	0	8	8
239	R:R:V238	R:R:V239	1.6	No	No	0	8	5
240	R:R:T45	R:R:V49	1.59	No	No	0	5	3
241	R:R:T148	R:R:V152	1.59	No	No	0	4	3
242	R:R:A91	R:R:L97	1.58	No	No	0	5	3
243	R:R:I42	R:R:V43	1.54	No	No	0	4	6
244	R:R:I52	R:R:V75	1.54	No	No	0	7	5
245	R:R:I112	R:R:V159	1.54	No	No	0	5	2
246	R:R:I122	R:R:V118	1.54	No	No	0	8	8
247	R:R:I205	R:R:V238	1.54	No	No	0	6	8
248	R:R:H94	R:R:P95	1.53	No	No	0	5	4
249	R:R:M40	R:R:V43	1.52	No	No	0	7	6
250	R:R:K225	R:R:V223	1.52	No	No	0	3	3
251	R:R:M228	R:R:T230	1.51	No	No	0	4	8
252	R:R:L124	R:R:S66	1.5	No	No	0	9	8
253	R:R:L106	R:R:V177	1.49	No	No	0	5	3
254	R:R:N213	R:R:V216	1.48	No	Yes	0	3	5
255	R:R:N265	R:R:V263	1.48	No	No	0	5	1
256	R:R:I122	R:R:M126	1.46	No	No	0	8	5
257	R:R:I112	R:R:L79	1.43	No	No	0	5	6
258	R:R:I220	R:R:N221	1.42	No	No	0	4	3
259	R:R:Q229	R:R:T230	1.42	No	No	0	7	8
260	R:R:Q300	R:R:T299	1.42	No	No	0	6	6
261	R:R:G36	R:R:W38	1.41	No	No	0	3	3
262	R:R:C109	R:R:F87	1.4	No	No	0	4	6
263	R:R:C119	R:R:F154	1.4	No	No	0	6	7
264	R:R:H232	R:R:V297	1.38	No	No	0	5	7
265	R:R:I273	R:R:Q269	1.37	No	No	0	4	3
266	R:R:V223	R:R:Y222	1.26	No	No	0	3	4
267	R:R:F274	R:R:I273	1.26	No	No	0	2	4
268	R:R:T53	R:R:Y57	1.25	No	No	0	3	4
269	R:R:T211	R:R:Y210	1.25	Yes	No	0	8	4
270	R:R:F191	R:R:K195	1.24	No	No	0	4	4
271	R:R:V159	R:R:W155	1.23	No	Yes	0	2	9
272	R:R:H93	R:R:H94	1.19	No	No	0	4	5
273	R:R:L202	R:R:Y201	1.17	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L21	3.3375	4	0	3
2	R:R:T24	4.155	4	0	4
3	R:R:E31	11.5575	4	4	4
4	R:R:D67	4.458	5	0	7
5	R:R:Y69	8.865	4	0	7
6	R:R:Y111	7.99	4	1	5
7	R:R:W155	4.59	4	6	9
8	R:R:H165	7.11833	6	1	4
9	R:R:E179	5.675	4	2	3
10	R:R:F180	4.576	5	0	5
11	R:R:F188	6.03	5	1	3
12	R:R:P189	5.22	4	1	4
13	R:R:P204	4.46	4	0	9
14	R:R:T211	3.5125	4	7	8
15	R:R:M215	4.0275	4	7	8
16	R:R:V216	2.99	4	8	5
17	R:R:W245	5.894	5	0	9
18	R:R:I272	4.5	4	2	5
19	R:R:L276	5.155	4	2	4
20	R:R:Q280	6.075	4	0	5
21	R:R:Y284	6.04	4	5	7
22	R:R:N290	5.28	4	0	9
23	R:R:D304	5.22	4	3	5
24	R:R:T308	8.0825	4	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E31	R:R:T20	30.6337	4.23	Yes	No	0	4	4
2	R:R:L21	R:R:T20	29.9911	2.95	Yes	No	0	3	4
3	R:R:L21	R:R:S23	10.2049	3	Yes	No	0	3	5
4	R:R:I26	R:R:T24	17.5404	6.08	No	Yes	0	1	4
5	R:R:L21	R:R:T24	16.7006	4.42	Yes	Yes	0	3	4
6	R:R:F30	R:R:Y27	14.2575	14.44	No	No	0	2	5
7	R:R:E31	R:R:Y27	46.0809	8.98	Yes	No	0	4	5
8	R:R:E179	R:R:I26	14.7665	5.47	Yes	No	2	3	1
9	R:R:Q280	R:R:Y27	51.8895	10.15	Yes	No	0	5	5
10	R:R:E31	R:R:R34	32.695	19.77	Yes	No	4	4	4
11	R:R:R34	R:R:V37	31.4671	2.62	No	No	0	4	7
12	R:R:V37	R:R:Y284	30.0929	7.57	No	Yes	0	7	7
13	R:R:C41	R:R:Y284	12.667	2.69	No	Yes	0	7	7
14	R:R:M40	R:R:V43	11.1274	1.52	No	No	0	7	6
15	R:R:M40	R:R:Y284	12.5143	7.18	No	Yes	5	7	7
16	R:R:F110	R:R:Q280	54.2563	5.86	No	Yes	0	7	5
17	R:R:F110	R:R:W245	100	4.01	No	Yes	0	7	9
18	R:R:R286	R:R:W245	95.1648	11	No	Yes	0	9	9
19	R:R:N290	R:R:R286	94.115	9.64	Yes	No	0	9	9
20	R:R:I293	R:R:N290	95.3684	2.83	No	Yes	0	8	9
21	R:R:I293	R:R:Y294	94.484	4.84	No	No	0	8	9
22	R:R:I70	R:R:Y294	93.886	12.09	No	No	0	8	9
23	R:R:D67	R:R:I70	93.4597	2.8	Yes	No	0	7	8
24	R:R:D67	R:R:I55	32.765	9.8	Yes	No	0	7	7
25	R:R:I55	R:R:M301	25.9702	2.92	No	No	0	7	9
26	R:R:K61	R:R:M301	24.6151	7.2	No	No	0	5	9
27	R:R:D304	R:R:K61	23.1709	4.15	Yes	No	0	5	5
28	R:R:D304	R:R:T54	12.5652	4.34	Yes	No	3	5	7
29	R:R:M305	R:R:T54	11.3055	7.53	No	No	0	6	7
30	R:R:D127	R:R:Y69	51.0943	4.6	No	Yes	0	8	7
31	R:R:T68	R:R:Y69	72.6428	6.24	No	Yes	0	7	7
32	R:R:D67	R:R:T68	73.5399	2.89	Yes	No	0	7	7
33	R:R:D127	R:R:S66	48.8612	5.89	No	No	0	8	8
34	R:R:R128	R:R:S66	45.3047	5.27	No	No	0	9	8
35	R:R:N72	R:R:V151	17.1078	2.96	No	No	0	9	7
36	R:R:V151	R:R:Y69	22.8401	2.52	No	Yes	0	7	7
37	R:R:N72	R:R:W155	14.0158	4.52	No	Yes	6	9	9
38	R:R:L21	R:R:V102	11.0383	2.98	Yes	No	0	3	5
39	R:R:E100	R:R:R99	10.9938	8.14	No	No	0	2	7
40	R:R:F110	R:R:Y111	69.7035	3.09	No	Yes	0	7	5
41	R:R:E175	R:R:F180	47.7224	3.5	No	Yes	0	3	5
42	R:R:E255	R:R:F180	44.853	7	No	Yes	0	5	5
43	R:R:E179	R:R:E255	11.49	3.81	Yes	No	2	3	5
44	R:R:F241	R:R:W245	26.0593	6.01	No	Yes	0	9	9
45	R:R:F241	R:R:P204	20.257	7.22	No	Yes	0	9	9
46	R:R:M215	R:R:R128	17.0887	2.48	Yes	No	0	8	9
47	R:R:R128	R:R:T230	29.7112	5.17	No	No	0	9	8
48	R:R:H165	R:R:L192	12.6225	11.57	Yes	No	1	4	4
49	R:R:E179	R:R:I272	13.3605	5.47	Yes	Yes	2	3	5
50	R:R:I272	R:R:L254	37.4793	2.85	Yes	No	0	5	5
51	R:R:L250	R:R:L254	33.4457	2.77	No	No	0	5	5
52	R:R:F246	R:R:L250	29.2467	3.65	No	No	0	5	5
53	R:R:F246	R:R:Y201	23.4699	4.13	No	No	0	5	9
54	R:R:N249	R:R:Y201	17.4895	9.3	No	No	0	9	9
55	R:R:N197	R:R:N249	14.423	4.09	No	No	0	6	9
56	R:R:M228	R:R:T230	24.2843	1.51	No	No	0	4	8
57	R:R:K225	R:R:M228	21.5613	11.52	No	No	0	3	4
58	R:R:K225	R:R:V223	18.6092	1.52	No	No	0	3	3
59	R:R:G224	R:R:V223	15.6063	1.84	No	No	0	3	3
60	R:R:G224	R:R:I220	14.0858	1.76	No	No	0	3	4
61	R:R:I220	R:R:W226	11.0065	5.87	No	No	0	4	3
62	R:R:H165	R:R:Y111	20.3906	15.24	Yes	Yes	1	4	5
63	R:R:E175	R:R:Y111	48.2377	8.98	No	Yes	0	3	5
64	R:R:E255	R:R:I272	33.0131	6.83	No	Yes	2	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7RKX_nogp

PDB Summary
PDB	7RKX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.72
Number of Linked Nodes	255
Number of Links	273
Number of Hubs	24
Number of Links mediated by Hubs	94
Number of Communities	8
Number of Nodes involved in Communities	34
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	32268
Length Of Smallest Path	3
Average Path Length	15.4401
Length of Longest Path	38
Minimum Path Strength	1.315
Average Path Strength	5.77747
Maximum Path Strength	16.485
Minimum Path Correlation	0.7
Average Path Correlation	0.923526
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	41.5992
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	30.0982
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • chemotaxis • response to stimulus • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cellular process • cell motility • locomotion • regulation of biological process • regulation of cellular process • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • immune response • immune system process • virion component • cellular anatomical structure • membrane • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P09703
Sequence	>7RKX_nogp_Chain_R T L N S T E I Y Q L F E Y T R L G V W L M C I V G T F L N V L V I T T I L Y Y R R K K K S P S D T Y I C N L A V A D L L I V V G L P F F L E Y A K H H P K L S R E V V C S G L N A C F Y I C L F A G V C F L I N L S M D R Y C V I V W T C W V V I F W I L A V L M G M P H Y L M Y S H T N N E C V G E F A N E G W F P V F L N T K V N I C G Y L A P I A L M A Y T Y N R M V R F I I N Y V G K W H M Q T L H V L L V V V V S F A S F W F P F N L A L F L E S I R L L A G V Y N D T L Q N V I I F C L Y V G Q F L A Y V R A C L N P G I Y I L V G T Q M R K D M W T T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RKX	A	Other	Unclassified	US27	Human betaherpesvirus 5	-	-	Gi1/β1/γ2	3.1	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKX (No Gprot)	A	Other	Unclassified	US27	Human betaherpesvirus 5	-	-		3.1	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKY	A	Other	Unclassified	US27	Human betaherpesvirus 5	-	GDP	Gi1/β1/γ2	3.8	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKY (No Gprot)	A	Other	Unclassified	US27	Human betaherpesvirus 5	-	GDP		3.8	2022-01-26	doi.org/10.1126/sciadv.abl5442

there is no ligand in network 7RKX_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.