Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 3.2025402
2A:A:I19 2.835429
3A:A:K46 3.98409
4A:A:T48 3.2325489
5A:A:I49 3.68167687
6A:A:Q52 4.765489
7A:A:H188 8.075413
8A:A:F191 7.5275405
9A:A:F196 7.9775407
10A:A:F199 7.366515
11A:A:Q204 4.045419
12A:A:S206 4.7575418
13A:A:K210 5.045409
14A:A:W211 3.715819
15A:A:H213 5.2725418
16A:A:F215 4.43667619
17A:A:F223 3.93333619
18A:A:V225 3.115407
19A:A:L227 4.615417
20A:A:Y230 5.10714718
21A:A:D231 7.615419
22A:A:F250 4.61167619
23A:A:C254 3.992515
24A:A:W258 6.28857715
25A:A:F259 3.67619
26A:A:T262 2.4925417
27A:A:I265 2.67254108
28A:A:F267 3.472509
29A:A:L268 5.69418
30A:A:F274 3.86833619
31A:A:K277 5.085419
32A:A:Y287 7.24717
33A:A:Y290 7.37407
34A:A:Y296 5.038514
35A:A:E298 4.40254154
36A:A:Y302 11.6225416
37A:A:I303 2.875417
38A:A:F307 3.97508
39A:A:E308 5.305413
40A:A:I319 3.81415
41A:A:Y320 5.446107
42A:A:T321 5.0125415
43A:A:F323 4.2075414
44A:A:T324 4.836589
45A:A:F336 4.98408
46A:A:D341 3.784108
47A:A:V342 3.264107
48A:A:F354 5.71405
49B:B:L14 2.76408
50B:B:R22 5.3475446
51B:B:V40 3.785163
52B:B:M45 3.785414
53B:B:R48 4.406527
54B:B:R49 3.3427
55B:B:H54 7.23729
56B:B:Y59 6.598518
57B:B:M61 3.6426
58B:B:W63 4.19857727
59B:B:D76 4.176529
60B:B:I81 3.608557
61B:B:W82 7.45429729
62B:B:Y85 10.44424
63B:B:N88 4.8125407
64B:B:K89 4.83571729
65B:B:H91 5.3375455
66B:B:I93 4.7175457
67B:B:L95 3.4825458
68B:B:W99 5.67857719
69B:B:Y105 3.535656
70B:B:N110 5.11414
71B:B:Y111 5.2525414
72B:B:C114 3.725458
73B:B:L117 2.89519
74B:B:Y124 4.214556
75B:B:T128 3.1425403
76B:B:V133 4.295454
77B:B:L139 4.39409
78B:B:H142 4.6625819
79B:B:Y145 3.6311018
80B:B:R150 5.08436
81B:B:F151 3.10167619
82B:B:L152 4.245403
83B:B:D154 5.325416
84B:B:V158 3.2625435
85B:B:S161 6.72419
86B:B:D163 7.435419
87B:B:T165 4.7525417
88B:B:W169 7.07618
89B:B:I171 3.095416
90B:B:F180 6.518537
91B:B:H183 7.88639
92B:B:D186 3.722519
93B:B:L190 3.888535
94B:B:F199 6.142539
95B:B:V200 5.5575446
96B:B:C204 4.0225407
97B:B:D205 5.955439
98B:B:S207 4.105435
99B:B:K209 10.2425436
100B:B:W211 8.93538
101B:B:D212 5.474199
102B:B:Q220 5.7375447
103B:B:F222 6.7025448
104B:B:H225 9.6549
105B:B:D228 6.7875409
106B:B:I232 4.43548
107B:B:F235 5.066676116
108B:B:P236 5.30754117
109B:B:F241 4.96143746
110B:B:T243 3.898548
111B:B:D247 6.0725449
112B:B:R251 8.456548
113B:B:F253 5.81546
114B:B:D254 3.6725409
115B:B:D258 8.5425447
116B:B:Q259 3.9425406
117B:B:M262 6.0825414
118B:B:Y264 5.12615
119B:B:H266 4.3375404
120B:B:C271 4.6075415
121B:B:T274 2.625418
122B:B:F278 4.854117
123B:B:R283 6.865169
124B:B:L285 4.14406
125B:B:Y289 5.28714717
126B:B:D290 7.285416
127B:B:N295 6.7025416
128B:B:W297 3.035418
129B:B:R304 5.32415
130B:B:H311 7.29519
131B:B:T321 5.2225427
132B:B:M325 4.28405
133B:B:S331 5.8825419
134B:B:W332 9.13719
135B:B:D333 5.4875419
136B:B:L336 3.56427
137B:B:K337 4.915416
138B:B:W339 6.33833619
139G:G:R27 4.932548
140G:G:M38 3.28254184
141G:G:Y40 6.28754116
142G:G:D48 5.794509
143G:G:L51 4.2925166
144G:G:N59 5.94429
145G:G:P60 5.2875429
146G:G:F61 3.35556928
147R:R:T24 3.842574
148R:R:F30 7.08754122
149R:R:E31 10.3265124
150R:R:W38 5.55754203
151R:R:I52 1.965407
152R:R:T54 5.4885177
153R:R:Y58 7.74254174
154R:R:S66 3.334598
155R:R:Y69 8.4697
156R:R:V81 1.62754216
157R:R:R99 13.7477
158R:R:Y111 7.99465
159R:R:F115 3.1625467
160R:R:W155 4.59499
161R:R:P164 3.3468
162R:R:H165 7.11833664
163R:R:N174 5.1625464
164R:R:E175 4.36463
165R:R:E179 5.675473
166R:R:F180 4.576505
167R:R:F188 5.428563
168R:R:P189 5.22464
169R:R:Y201 4.1325409
170R:R:P204 4.464229
171R:R:T211 3.51254138
172R:R:M215 4.02754138
173R:R:V216 2.994145
174R:R:V223 3.025403
175R:R:T230 4.18408
176R:R:V238 3.064148
177R:R:F241 4.8754229
178R:R:W245 4.77143709
179R:R:I272 4.5475
180R:R:L276 5.155474
181R:R:Q280 7.2654125
182R:R:Y284 4.762507
183R:R:N290 5.28409
184R:R:D304 5.224175
185R:R:M305 6.6475406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:L69 12.73814.07NoNo085
2B:B:L69 B:B:Y105 22.66432.34NoYes056
3B:B:H62 B:B:Y105 24.50093.27NoYes066
4B:B:H62 B:B:R150 24.74411.28NoYes066
5B:B:L190 B:B:R150 25.05592.43YesYes356
6B:B:L190 B:B:S160 32.91884.5YesNo056
7B:B:S147 B:B:S160 50.04483.26NoNo096
8B:B:S147 B:B:Y145 50.31592.54NoYes098
9A:A:W211 B:B:Y145 35.92341.93YesYes198
10A:A:F215 A:A:W211 20.71084.01YesYes199
11A:A:F199 A:A:F215 55.07293.22YesYes159
12A:A:F199 A:A:K197 1002.48YesNo156
13B:B:L117 B:B:Y145 37.09192.34YesYes198
14A:A:F215 B:B:L117 20.27622.44YesYes199
15B:B:L117 B:B:W99 20.18924.56YesYes199
16A:A:F199 B:B:W99 45.232812.03YesYes159
17A:A:H188 A:A:K197 99.10179.17YesNo136
18A:A:E58 A:A:H188 98.517311.08NoYes043
19A:A:E58 A:A:I56 98.3464.1NoNo047
20A:A:I55 A:A:I56 98.38924.42NoNo087
21A:A:F189 A:A:I55 98.21662.51NoNo098
22A:A:F189 A:A:F196 98.043613.93NoYes097
23A:A:F196 A:A:L194 97.17354.87YesNo074
24A:A:F336 A:A:L194 96.99843.65YesNo084
25A:A:F191 A:A:F336 96.22467.5YesYes058
26A:A:F191 A:A:V332 95.762710.49YesNo057
27A:A:M53 A:A:V332 95.58473.04NoNo087
28A:A:I49 A:A:M53 95.40642.92YesNo078
29A:A:I49 A:A:T324 90.97593.04YesYes879
30A:A:F267 A:A:T324 90.62645.19YesYes099
31A:A:F215 A:A:L37 17.47287.31YesNo099
32A:A:L37 A:A:L39 17.26825.54NoNo099
33A:A:R208 A:A:W211 11.13125NoYes099
34A:A:L249 A:A:R208 10.96343.64NoNo099
35A:A:F223 A:A:L249 10.85616.09YesNo099
36B:B:G330 B:B:S331 12.62851.86NoYes059
37B:B:S331 B:B:V315 12.9253.23YesNo197
38B:B:G288 B:B:V315 14.92871.84NoNo177
39B:B:G288 B:B:T274 15.0571.82NoYes178
40B:B:R314 B:B:T274 13.61152.59NoYes188
41B:B:R314 B:B:W332 46.452516.99NoYes189
42A:A:W258 B:B:W332 22.55542.81YesYes159
43A:A:F259 A:A:W258 13.82112YesYes195
44A:A:F259 A:A:I253 13.71795.02YesNo198
45A:A:I212 A:A:W211 10.70833.52NoYes189
46A:A:F223 A:A:V225 22.18042.62YesYes097
47A:A:F274 A:A:Y230 12.28455.16YesYes198
48A:A:F307 A:A:V225 13.75945.24YesYes087
49A:A:F307 A:A:I303 17.53172.51YesYes087
50A:A:F223 A:A:F250 16.94597.5YesYes199
51A:A:F250 A:A:F307 13.94572.14YesYes098
52B:B:W332 B:B:Y59 24.19963.86YesYes198
53A:A:F267 A:A:I265 89.44832.51YesYes098
54A:A:I265 A:A:Y320 88.7542.42YesYes1087
55A:A:D341 A:A:Y320 88.03496.9YesYes1087
56A:A:D341 R:R:Y222 87.89081.15YesNo084
57R:R:V223 R:R:Y222 87.10711.26YesNo034
58R:R:K225 R:R:V223 85.80273.04NoYes033
59R:R:K225 R:R:M228 85.40524.32NoNo034
60A:A:G352 R:R:M228 85.3231.75NoNo084
61A:A:G352 R:R:T230 85.12293.64NoYes088
62B:B:C271 B:B:D290 36.0776.22YesYes156
63B:B:C271 B:B:Y289 35.40544.03YesYes157
64B:B:I273 B:B:Y289 22.74817.25NoYes067
65B:B:G244 B:B:I273 22.55221.76NoNo056
66B:B:G244 B:B:T243 20.43651.82NoYes058
67B:B:D258 B:B:F222 12.69474.78YesYes478
68B:B:W297 B:B:Y289 16.52662.89YesYes187
69B:B:W297 B:B:Y264 16.3433.86YesYes185
70B:B:R68 B:B:Y85 18.597625.72NoYes054
71B:B:Y85 G:G:P60 10.24688.34YesYes249
72B:B:Q75 B:B:Y59 24.541113.53NoYes098
73B:B:Q75 B:B:W99 24.63044.38NoYes099
74B:B:G162 B:B:Y145 24.41674.35NoYes198
75B:B:G162 B:B:S161 24.1693.71NoYes199
76B:B:H142 B:B:S161 21.533613.95YesYes199
77B:B:H142 B:B:W169 17.82122.12YesYes198
78B:B:I157 B:B:W169 14.45073.52NoYes178
79B:B:I123 B:B:Y111 11.45083.63NoYes164
80B:B:S160 B:B:V187 17.70324.85NoNo069
81B:B:H183 B:B:V187 16.25725.54YesNo399
82G:G:E22 G:G:Q18 16.02811.47NoNo099
83G:G:M21 G:G:Q18 14.69434.08NoNo019
84B:B:M217 G:G:M21 13.36022.89NoNo031
85R:R:R128 R:R:T230 77.29675.17NoYes098
86R:R:R128 R:R:S66 74.9835.27NoYes098
87R:R:S66 R:R:Y69 73.5492.54YesYes987
88R:R:F120 R:R:Y69 70.93652.06NoYes987
89R:R:F120 R:R:W155 70.44510.02NoYes989
90R:R:A116 R:R:W155 69.10742.59NoYes079
91R:R:A116 R:R:A76 68.65541.79NoNo079
92R:R:A76 R:R:C113 68.42881.81NoNo098
93R:R:C113 R:R:I80 68.2026.55NoNo087
94R:R:I80 R:R:L84 67.74712.85NoNo078
95R:R:L84 R:R:Y284 67.51922.34NoYes087
96R:R:Q280 R:R:Y284 62.13573.38YesYes057
97R:R:Q280 R:R:Y27 60.599415.78YesNo1255
98R:R:E31 R:R:Y27 60.5218.98YesNo1245
99R:R:E31 R:R:T20 59.75884.23YesNo044
100R:R:L21 R:R:T20 58.79722.95NoNo034
101R:R:L21 R:R:T24 58.31424.42NoYes034
102R:R:I26 R:R:T24 24.97016.08NoYes714
103R:R:C176 R:R:T24 29.71893.38NoYes094
104R:R:E179 R:R:I26 22.45255.47YesNo731
105R:R:E179 R:R:E255 17.26413.81YesNo735
106R:R:E255 R:R:F180 17.16197NoYes055
107R:R:E175 R:R:F180 13.03763.5YesYes035
108R:R:E175 R:R:F248 25.0572.33YesNo037
109R:R:F248 R:R:W245 22.17562NoYes079
110R:R:R286 R:R:W245 12.099111NoYes099
111R:R:C103 R:R:C176 29.4557.28NoNo099
112R:R:C103 R:R:N107 29.19646.3NoNo097
113R:R:N107 R:R:N174 28.94439.54NoYes074
114R:R:E175 R:R:N174 12.75112.63YesYes634
115R:R:N174 R:R:Y111 11.52424.65YesYes645
116R:R:F110 R:R:Y111 11.56293.09NoYes075
117R:R:F110 R:R:W245 11.27914.01NoYes079
118R:R:F241 R:R:W245 18.97996.01YesYes099
119R:R:F241 R:R:P204 12.08527.22YesYes2299
120R:R:M208 R:R:P204 10.37571.68NoYes089
121A:A:F223 A:A:L39 16.99982.44YesNo199
122A:A:F223 A:A:I253 13.51862.51YesNo198
123B:B:D290 B:B:R314 32.744916.68YesNo168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7RKX
Class A
SubFamily Other
Type Unclassified
SubType US27
Species Human betaherpesvirus 5
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-01-26
D.O.I. 10.1126/sciadv.abl5442
Net Summary
Imin 1.82
Number of Linked Nodes 833
Number of Links 1053
Number of Hubs 185
Number of Links mediated by Hubs 676
Number of Communities 23
Number of Nodes involved in Communities 274
Number of Links involved in Communities 401
Path Summary
Number Of Nodes in MetaPath 124
Number Of Links MetaPath 123
Number of Shortest Paths 998111
Length Of Smallest Path 3
Average Path Length 36.5133
Length of Longest Path 82
Minimum Path Strength 1.205
Average Path Strength 5.07489
Maximum Path Strength 20.68
Minimum Path Correlation 0.7
Average Path Correlation 0.982864
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5625
Average % Of Corr. Nodes 44.9085
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.027
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7RKX_Chain_A
GCTLSAEDK AAVERSKMI DRNLREDGE KAAREVKLL LLGAGESGK 
STIVKQMKI IHETGIVET HFTFKDLHF KMFDVGGQR SERKKWIHC 
FEGVTAIIF CVALSDYDL VNRMHESMK LFDSICNNK WFTDTSIIL 
FLNKKDLFE EKIKKSPLT ICYPEYAGS NTYEEAAAY IQCQFEDLN 
KRKDTKEIY THFTCATDT KNVQFVFDA VTDVIIKNN LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7RKX_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7RKX_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP09703
Sequence
>7RKX_Chain_R
TLNSTEIYQ LFEYTRLGV WLMCIVGTF LNVLVITTI LYYRRKKKS 
PSDTYICNL AVADLLIVV GLPFFLEYA KHHPKLSRE VVCSGLNAC 
FYICLFAGV CFLINLSMD RYCVIVWTC WVVIFWILA VLMGMPHYL 
MYSHTNNEC VGEFANEGW FPVFLNTKV NICGYLAPI ALMAYTYNR 
MVRFIINYV GKWHMQTLH VLLVVVVSF ASFWFPFNL ALFLESIRL 
LAGVYNDTL QNVIIFCLY VGQFLAYVR ACLNPGIYI LVGTQMRKD 
MWTTL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RKXAOtherUnclassifiedUS27Human betaherpesvirus 5--Gi1/&β;1/&γ;23.12022-01-2610.1126/sciadv.abl5442




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7RKX.zip



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