Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 3.2025402
2A:A:I19 2.835429
3A:A:K46 3.98409
4A:A:T48 3.2325489
5A:A:I49 3.68167687
6A:A:Q52 4.765489
7A:A:H188 8.075413
8A:A:F191 7.5275405
9A:A:F196 7.9775407
10A:A:F199 7.366515
11A:A:Q204 4.045419
12A:A:S206 4.7575418
13A:A:K210 5.045409
14A:A:W211 3.715819
15A:A:H213 5.2725418
16A:A:F215 4.43667619
17A:A:F223 3.93333619
18A:A:V225 3.115407
19A:A:L227 4.615417
20A:A:Y230 5.10714718
21A:A:D231 7.615419
22A:A:F250 4.61167619
23A:A:C254 3.992515
24A:A:N256 4.37418
25A:A:W258 6.28857715
26A:A:F259 3.67619
27A:A:T262 2.4925417
28A:A:I265 2.6725498
29A:A:F267 3.472509
30A:A:L268 5.69418
31A:A:F274 3.86833619
32A:A:K277 5.085419
33A:A:S281 2.95417
34A:A:Y287 6.31571717
35A:A:Y290 7.37407
36A:A:Y296 5.038514
37A:A:E298 4.40254134
38A:A:I303 2.875417
39A:A:F307 3.97508
40A:A:E308 5.305413
41A:A:I319 3.81415
42A:A:Y320 5.44697
43A:A:T321 5.0125415
44A:A:F323 4.2075414
45A:A:T324 4.836589
46A:A:F336 4.98408
47A:A:D341 3.78498
48A:A:V342 3.26497
49B:B:L14 2.76408
50B:B:R22 5.3475446
51B:B:V40 3.785143
52B:B:M45 3.785414
53B:B:R48 4.406527
54B:B:R49 3.3427
55B:B:H54 7.23729
56B:B:Y59 6.598518
57B:B:M61 3.6426
58B:B:W63 4.19857727
59B:B:D76 4.176529
60B:B:I81 3.608557
61B:B:W82 7.45429729
62B:B:Y85 10.44424
63B:B:N88 4.8125407
64B:B:K89 4.83571729
65B:B:H91 5.3375455
66B:B:I93 4.7175457
67B:B:L95 3.4825458
68B:B:W99 5.67857719
69B:B:Y105 3.535656
70B:B:N110 5.11414
71B:B:Y111 5.2525414
72B:B:A113 2.045419
73B:B:C114 3.725458
74B:B:L117 2.89519
75B:B:Y124 4.214556
76B:B:T128 3.1425403
77B:B:V133 4.295454
78B:B:L139 4.39409
79B:B:H142 4.6625819
80B:B:Y145 3.6311018
81B:B:R150 5.08436
82B:B:F151 3.10167619
83B:B:L152 4.245403
84B:B:D154 5.325416
85B:B:V158 3.2625435
86B:B:S161 6.72419
87B:B:D163 7.435419
88B:B:T165 4.7525417
89B:B:W169 7.07618
90B:B:I171 3.095416
91B:B:F180 6.518537
92B:B:H183 7.88639
93B:B:D186 3.722519
94B:B:L190 3.888535
95B:B:F199 6.142539
96B:B:V200 5.5575446
97B:B:C204 4.0225407
98B:B:D205 5.955439
99B:B:S207 4.105435
100B:B:K209 10.2425436
101B:B:W211 8.93538
102B:B:D212 5.474179
103B:B:Q220 5.7375447
104B:B:F222 6.7025448
105B:B:H225 9.6549
106B:B:D228 6.7875409
107B:B:I232 4.43548
108B:B:F235 5.066676106
109B:B:P236 5.30754107
110B:B:F241 4.96143746
111B:B:T243 3.898548
112B:B:D247 6.0725449
113B:B:R251 8.456548
114B:B:F253 5.81546
115B:B:D254 3.6725409
116B:B:D258 8.5425447
117B:B:Q259 3.9425406
118B:B:M262 6.0825414
119B:B:Y264 5.12615
120B:B:H266 4.3375404
121B:B:C271 4.6075415
122B:B:T274 2.625418
123B:B:F278 4.854107
124B:B:R283 6.865149
125B:B:L285 4.14406
126B:B:Y289 5.28714717
127B:B:D290 7.285416
128B:B:N295 6.7025416
129B:B:W297 3.035418
130B:B:R304 5.32415
131B:B:H311 7.29519
132B:B:T321 5.2225427
133B:B:M325 4.28405
134B:B:S331 5.8825419
135B:B:W332 9.13719
136B:B:D333 5.4875419
137B:B:L336 3.56427
138B:B:K337 4.915416
139B:B:W339 6.33833619
140G:G:R27 4.932548
141G:G:M38 3.28254164
142G:G:Y40 6.28754106
143G:G:D48 5.794509
144G:G:L51 4.2925146
145G:G:N59 5.94429
146G:G:P60 5.2875429
147G:G:F61 3.35556928
148R:R:L21 3.3375403
149R:R:T24 3.842574
150R:R:E31 11.55754184
151R:R:Y58 7.74254154
152R:R:S66 3.84118
153R:R:D67 4.458507
154R:R:Y69 6.676676117
155R:R:R99 8.7025477
156R:R:Y111 7.99465
157R:R:F115 3.785467
158R:R:W155 4.594119
159R:R:P164 2.8825468
160R:R:H165 7.11833664
161R:R:N174 5.1625464
162R:R:E175 4.36463
163R:R:E179 5.675473
164R:R:F180 4.576505
165R:R:F188 6.03563
166R:R:P189 5.22464
167R:R:Y201 4.1325409
168R:R:P204 4.464209
169R:R:T211 3.51254128
170R:R:M215 4.02754128
171R:R:V216 2.994215
172R:R:T230 4.18408
173R:R:F241 4.8754209
174R:R:W245 4.77143709
175R:R:I272 4.5475
176R:R:L276 5.155474
177R:R:Q280 6.075405
178R:R:Y284 5.35197
179R:R:N290 5.28409
180R:R:D304 5.224155
181R:R:T308 8.08254155
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:L69 13.08094.07NoNo085
2B:B:L69 B:B:Y105 23.45622.34NoYes056
3B:B:H62 B:B:Y105 22.79533.27NoYes066
4B:B:H62 B:B:R150 23.029911.28NoYes066
5B:B:L190 B:B:R150 23.32932.43YesYes356
6B:B:L190 B:B:S160 31.08774.5YesNo056
7B:B:S147 B:B:S160 48.06883.26NoNo096
8B:B:S147 B:B:Y145 48.33622.54NoYes098
9A:A:W211 B:B:Y145 35.63351.93YesYes198
10A:A:F215 A:A:W211 20.26154.01YesYes199
11A:A:F199 A:A:F215 55.39573.22YesYes159
12A:A:F199 A:A:K197 1002.48YesNo156
13B:B:L117 B:B:Y145 35.71532.34YesYes198
14A:A:F215 B:B:L117 21.11692.44YesYes199
15B:B:L117 B:B:W99 20.96274.56YesYes199
16A:A:F199 B:B:W99 44.951712.03YesYes159
17A:A:H188 A:A:K197 99.03659.17YesNo136
18A:A:E58 A:A:H188 98.400111.08NoYes043
19A:A:E58 A:A:I56 98.21054.1NoNo047
20A:A:I55 A:A:I56 98.22814.42NoNo087
21A:A:F189 A:A:I55 98.03732.51NoNo098
22A:A:F189 A:A:F196 97.846113.93NoYes097
23A:A:F196 A:A:L194 96.88464.87YesNo074
24A:A:F336 A:A:L194 96.69123.65YesNo084
25A:A:F191 A:A:F336 95.84677.5YesYes058
26A:A:F191 A:A:V332 95.327110.49YesNo057
27A:A:M53 A:A:V332 95.13083.04NoNo087
28A:A:I49 A:A:M53 94.93412.92YesNo078
29A:A:I49 A:A:T324 90.77283.04YesYes879
30A:A:F267 A:A:T324 90.15415.19YesYes099
31A:A:F215 A:A:L37 17.7167.31YesNo099
32A:A:L37 A:A:L39 17.50965.54NoNo099
33A:A:R208 A:A:W211 12.13045NoYes099
34A:A:L249 A:A:R208 11.79763.64NoNo099
35A:A:F223 A:A:L249 11.58836.09YesNo099
36B:B:G330 B:B:S331 12.71991.86NoYes059
37B:B:S331 B:B:V315 12.86723.23YesNo197
38B:B:G288 B:B:V315 14.73131.84NoNo177
39B:B:G288 B:B:T274 14.86321.82NoYes178
40B:B:R314 B:B:T274 13.42792.59NoYes188
41B:B:R314 B:B:W332 46.905616.99NoYes189
42A:A:W258 B:B:W332 23.84232.81YesYes159
43A:A:F259 A:A:W258 14.722YesYes195
44A:A:F259 A:A:I253 14.71715.02YesNo198
45A:A:I212 A:A:W211 10.64093.52NoYes189
46A:A:F223 A:A:V225 23.3152.62YesYes097
47A:A:F274 A:A:Y230 12.95565.16YesYes198
48A:A:F307 A:A:V225 14.84955.24YesYes087
49A:A:F307 A:A:I303 19.64722.51YesYes087
50A:A:F274 A:A:I303 10.26362.51YesYes197
51A:A:F223 A:A:F250 17.64577.5YesYes199
52A:A:F250 A:A:F307 15.01712.14YesYes098
53B:B:W332 B:B:Y59 23.38193.86YesYes198
54A:A:F267 A:A:I265 88.41212.51YesYes098
55A:A:I265 A:A:Y320 87.66842.42YesYes987
56A:A:D341 A:A:Y320 86.64756.9YesYes987
57A:A:D341 R:R:Y222 86.45821.15YesNo084
58R:R:V223 R:R:Y222 85.60471.26NoNo034
59A:A:L348 R:R:V223 83.22755.96NoNo093
60A:A:L348 R:R:I219 83.00924.28NoNo098
61R:R:I219 R:R:M228 82.79062.92NoNo084
62A:A:G352 R:R:M228 82.13241.75NoNo084
63A:A:G352 R:R:T230 81.91223.64NoYes088
64B:B:C271 B:B:D290 36.74836.22YesYes156
65B:B:C271 B:B:Y289 36.06224.03YesYes157
66B:B:I273 B:B:Y289 23.2767.25NoYes067
67B:B:G244 B:B:I273 23.07561.76NoNo056
68B:B:G244 B:B:T243 20.91111.82NoYes058
69B:B:D258 B:B:F222 12.99084.78YesYes478
70B:B:W297 B:B:Y289 16.55182.89YesYes187
71B:B:W297 B:B:Y264 16.36533.86YesYes185
72B:B:D83 B:B:R68 10.104814.29NoNo085
73B:B:R68 B:B:Y85 19.420925.72NoYes054
74B:B:Y85 G:G:P60 11.01768.34YesYes249
75B:B:Q75 B:B:Y59 23.718113.53NoYes098
76B:B:Q75 B:B:W99 23.81084.38NoYes099
77B:B:D66 B:B:L69 10.18014.07NoNo085
78B:B:I123 B:B:Y111 13.95793.63NoYes164
79B:B:G162 B:B:Y145 21.57754.35NoYes198
80B:B:G162 B:B:S161 21.36073.71NoYes199
81B:B:H142 B:B:S161 18.740313.95YesYes199
82B:B:H142 B:B:W169 15.022.12YesYes198
83B:B:I157 B:B:W169 11.98863.52NoYes178
84B:B:S160 B:B:V187 17.58694.85NoNo069
85B:B:H183 B:B:V187 16.14565.54YesNo399
86G:G:E22 G:G:Q18 15.930911.47NoNo099
87G:G:M21 G:G:Q18 14.60534.08NoNo019
88B:B:M217 G:G:M21 13.27942.89NoNo031
89R:R:R128 R:R:T230 80.3615.17NoYes098
90R:R:R128 R:R:S66 77.88715.27NoYes098
91R:R:S66 R:R:Y69 76.36852.54YesYes1187
92R:R:F120 R:R:Y69 29.52572.06NoYes1187
93R:R:F120 R:R:W155 28.975510.02NoYes1189
94R:R:A116 R:R:W155 27.35572.59NoYes079
95R:R:A116 R:R:A76 26.85021.79NoNo079
96R:R:A76 R:R:C113 26.59731.81NoNo098
97R:R:C113 R:R:I80 26.34446.55NoNo087
98R:R:I80 R:R:L84 25.99352.85NoNo078
99R:R:L84 R:R:Q280 19.47693.99NoYes085
100R:R:Q280 R:R:Y27 12.417410.15YesNo055
101R:R:T68 R:R:Y69 44.44686.24NoYes077
102R:R:D67 R:R:T68 44.19352.89YesNo077
103R:R:D67 R:R:I70 37.26912.8YesNo078
104R:R:I70 R:R:Y294 37.021312.09NoNo089
105R:R:I293 R:R:Y294 36.77354.84NoNo089
106R:R:I293 R:R:N290 36.27832.83NoYes089
107R:R:N290 R:R:R286 34.85379.64YesNo099
108R:R:R286 R:R:W245 34.09411NoYes099
109R:R:F248 R:R:W245 13.2472NoYes079
110R:R:E175 R:R:F248 10.13392.33YesNo037
111R:R:F110 R:R:Y111 12.64153.09NoYes075
112A:A:F223 A:A:L39 17.2432.44YesNo199
113A:A:F223 A:A:I253 14.51292.51YesNo198
114B:B:D290 B:B:R314 33.379416.68YesNo168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7RKX
Class A
SubFamily Other
Type Unclassified
SubType US27
Species Human Betaherpesvirus 5
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-01-26
D.O.I. 10.1126/sciadv.abl5442
Net Summary
Imin 1.78
Number of Linked Nodes 834
Number of Links 1054
Number of Hubs 181
Number of Links mediated by Hubs 657
Number of Communities 21
Number of Nodes involved in Communities 260
Number of Links involved in Communities 383
Path Summary
Number Of Nodes in MetaPath 115
Number Of Links MetaPath 114
Number of Shortest Paths 991066
Length Of Smallest Path 3
Average Path Length 33.2775
Length of Longest Path 73
Minimum Path Strength 1.205
Average Path Strength 5.0891
Maximum Path Strength 20.68
Minimum Path Correlation 0.7
Average Path Correlation 0.984702
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 47.1307
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.6331
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • molecular transducer activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • C-C chemokine binding   • chemokine binding   • cytokine binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell chemotaxis   • chemotaxis   • response to external stimulus   • taxis   • cell migration   • cell motility   • locomotion   • calcium-mediated signaling   • immune response   • immune system process   • virion component   • host cell plasma membrane   • host cellular component   • host cell part   • host cell membrane
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7RKX_Chain_A
GCTLSAEDK AAVERSKMI DRNLREDGE KAAREVKLL LLGAGESGK 
STIVKQMKI IHETGIVET HFTFKDLHF KMFDVGGQR SERKKWIHC 
FEGVTAIIF CVALSDYDL VNRMHESMK LFDSICNNK WFTDTSIIL 
FLNKKDLFE EKIKKSPLT ICYPEYAGS NTYEEAAAY IQCQFEDLN 
KRKDTKEIY THFTCATDT KNVQFVFDA VTDVIIKNN LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7RKX_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7RKX_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP09703
Sequence
>7RKX_Chain_R
TLNSTEIYQ LFEYTRLGV WLMCIVGTF LNVLVITTI LYYRRKKKS 
PSDTYICNL AVADLLIVV GLPFFLEYA KHHPKLSRE VVCSGLNAC 
FYICLFAGV CFLINLSMD RYCVIVWTC WVVIFWILA VLMGMPHYL 
MYSHTNNEC VGEFANEGW FPVFLNTKV NICGYLAPI ALMAYTYNR 
MVRFIINYV GKWHMQTLH VLLVVVVSF ASFWFPFNL ALFLESIRL 
LAGVYNDTL QNVIIFCLY VGQFLAYVR ACLNPGIYI LVGTQMRKD 
MWTTL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RKYAOtherUnclassifiedUS27Human betaherpesvirus 5-GDPGi1/β1/γ23.82022-01-26doi.org/10.1126/sciadv.abl5442
7RKY (No Gprot) AOtherUnclassifiedUS27Human betaherpesvirus 5-GDP3.82022-01-26doi.org/10.1126/sciadv.abl5442
7RKXAOtherUnclassifiedUS27Human betaherpesvirus 5--Gi1/β1/γ23.12022-01-2610.1126/sciadv.abl5442
7RKX (No Gprot) AOtherUnclassifiedUS27Human betaherpesvirus 5--3.12022-01-2610.1126/sciadv.abl5442




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