psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I26	R:R:L276	5.71	No	No	0	1	4
2	R:R:F30	R:R:Y27	6.19	Yes	Yes	4	2	5
3	R:R:L88	R:R:Y27	2.34	No	Yes	0	7	5
4	R:R:Q280	R:R:Y27	9.02	No	Yes	0	5	5
5	R:R:F281	R:R:Y27	5.16	No	Yes	4	6	5
6	R:R:Y27	R:R:Y284	17.87	Yes	No	0	5	7
7	R:R:L29	R:R:Q28	5.32	No	No	0	3	4
8	R:R:Q28	R:R:Y32	2.25	No	No	0	4	4
9	R:R:F30	R:R:T33	2.59	Yes	No	0	2	5
10	R:R:F30	R:R:Y277	12.38	Yes	No	0	2	5
11	R:R:F281	R:R:F30	18.22	No	Yes	4	6	2
12	R:R:E31	R:R:V37	2.85	No	No	0	4	7
13	R:R:E31	R:R:L88	9.28	No	No	0	4	7
14	R:R:E31	R:R:K92	5.4	No	No	0	4	4
15	R:R:G36	R:R:L39	1.71	No	No	0	3	5
16	R:R:P85	R:R:V37	1.77	No	No	0	9	7
17	R:R:I42	R:R:L39	4.28	No	No	0	4	5
18	R:R:M40	R:R:V285	3.04	No	No	0	7	5
19	R:R:C41	R:R:P85	3.77	No	No	0	7	9
20	R:R:I42	R:R:V43	3.07	No	Yes	0	4	6
21	R:R:F46	R:R:I42	3.77	No	No	0	4	4
22	R:R:L47	R:R:V43	2.98	Yes	Yes	2	7	6
23	R:R:C288	R:R:V43	6.83	No	Yes	2	8	6
24	R:R:L289	R:R:V43	2.98	No	Yes	2	7	6
25	R:R:G44	R:R:L47	1.71	No	Yes	0	9	7
26	R:R:G44	R:R:N48	1.7	No	No	0	9	9
27	R:R:C288	R:R:G44	1.96	No	No	0	8	9
28	R:R:L289	R:R:L47	4.15	No	Yes	2	7	7
29	R:R:L47	R:R:P291	14.78	Yes	No	0	7	9
30	R:R:G292	R:R:L47	1.71	No	Yes	0	6	7
31	R:R:D77	R:R:N48	2.69	No	No	0	9	9
32	R:R:L78	R:R:N48	10.98	No	No	0	8	9
33	R:R:I52	R:R:V49	3.07	No	No	0	7	3
34	R:R:L50	R:R:M305	4.24	No	No	0	6	6
35	R:R:A74	R:R:V51	1.7	No	No	0	8	9
36	R:R:P291	R:R:V51	3.53	No	No	0	9	9
37	R:R:M301	R:R:V51	4.56	No	No	0	9	9
38	R:R:I52	R:R:L56	4.28	No	No	0	7	4
39	R:R:T53	R:R:Y57	7.49	No	No	0	3	4
40	R:R:K61	R:R:T54	6.01	No	Yes	0	5	7
41	R:R:M301	R:R:T54	6.02	No	Yes	0	9	7
42	R:R:D304	R:R:T54	2.89	No	Yes	0	5	7
43	R:R:I55	R:R:L56	2.85	No	No	0	7	4
44	R:R:D67	R:R:I55	5.6	Yes	No	0	7	7
45	R:R:C71	R:R:I55	8.18	No	No	0	6	7
46	R:R:L56	R:R:R60	2.43	No	No	0	4	5
47	R:R:T308	R:R:Y57	6.24	No	No	0	5	4
48	R:R:D304	R:R:Y58	18.39	No	Yes	0	5	4
49	R:R:T307	R:R:Y58	3.75	No	Yes	0	4	4
50	R:R:T308	R:R:Y58	6.24	No	Yes	0	5	4
51	R:R:D67	R:R:R60	3.57	Yes	No	5	7	5
52	R:R:R60	R:R:T68	5.17	No	No	5	5	7
53	R:R:P65	R:R:S64	1.78	No	No	0	7	7
54	R:R:D67	R:R:S64	4.42	Yes	No	0	7	7
55	R:R:D127	R:R:P65	1.61	No	No	0	8	7
56	R:R:N143	R:R:P65	3.26	Yes	No	0	6	7
57	R:R:S66	R:R:Y69	5.09	No	Yes	1	8	7
58	R:R:L124	R:R:S66	3	Yes	No	1	9	8
59	R:R:R128	R:R:S66	2.64	Yes	No	1	9	8
60	R:R:D67	R:R:T68	4.34	Yes	No	5	7	7
61	R:R:I70	R:R:Y69	9.67	No	Yes	1	8	7
62	R:R:F120	R:R:Y69	29.91	Yes	Yes	1	8	7
63	R:R:N123	R:R:Y69	5.81	No	Yes	0	7	7
64	R:R:L124	R:R:Y69	23.45	Yes	Yes	1	9	7
65	R:R:F120	R:R:I70	7.54	Yes	No	1	8	8
66	R:R:I70	R:R:Y294	3.63	No	No	0	8	9
67	R:R:F120	R:R:N72	2.42	Yes	No	0	8	9
68	R:R:N72	R:R:W155	5.65	No	No	0	9	9
69	R:R:D77	R:R:L73	5.43	No	No	0	9	9
70	R:R:F120	R:R:L73	28.01	Yes	No	1	8	9
71	R:R:L121	R:R:L73	2.77	No	No	1	8	9
72	R:R:A76	R:R:C113	1.81	No	No	0	9	8
73	R:R:A116	R:R:A76	1.79	No	No	0	7	9
74	R:R:D77	R:R:N290	4.04	No	No	0	9	9
75	R:R:L78	R:R:V82	4.47	No	No	0	8	5
76	R:R:C109	R:R:L79	3.17	No	No	0	4	6
77	R:R:I80	R:R:V81	3.07	Yes	No	6	7	6
78	R:R:I80	R:R:L84	5.71	Yes	Yes	0	7	8
79	R:R:C109	R:R:I80	1.64	No	Yes	0	4	7
80	R:R:F110	R:R:I80	7.54	No	Yes	0	7	7
81	R:R:C113	R:R:I80	11.46	No	Yes	0	8	7
82	R:R:A287	R:R:I80	1.62	No	Yes	6	9	7
83	R:R:A287	R:R:V81	1.7	No	No	6	9	6
84	R:R:G83	R:R:V82	3.68	No	No	0	7	5
85	R:R:C109	R:R:G83	1.96	No	No	0	4	7
86	R:R:L84	R:R:P85	3.28	Yes	No	0	8	9
87	R:R:L84	R:R:Y284	21.1	Yes	No	0	8	7
88	R:R:E89	R:R:F86	9.33	No	No	0	5	7
89	R:R:F87	R:R:G105	3.01	No	No	0	6	4
90	R:R:E89	R:R:Y90	5.61	No	No	0	5	5
91	R:R:H93	R:R:H94	14.33	No	No	0	4	5
92	R:R:S98	R:R:V102	3.23	No	No	0	7	5
93	R:R:G105	R:R:S104	1.86	No	No	0	4	8
94	R:R:A108	R:R:G105	1.95	No	No	0	6	4
95	R:R:N107	R:R:Y111	24.42	No	Yes	3	7	5
96	R:R:H165	R:R:N107	29.34	No	No	3	4	7
97	R:R:A108	R:R:Y166	5.34	No	No	0	6	4
98	R:R:A283	R:R:F110	4.16	No	No	0	8	7
99	R:R:F115	R:R:Y111	4.13	Yes	Yes	0	7	5
100	R:R:H165	R:R:Y111	11.98	No	Yes	3	4	5
101	R:R:L192	R:R:Y111	8.21	No	Yes	3	4	5
102	R:R:F115	R:R:L114	6.09	Yes	No	0	7	8
103	R:R:L114	R:R:V118	2.98	No	No	0	8	8
104	R:R:A158	R:R:F115	2.77	No	Yes	0	7	7
105	R:R:F115	R:R:M161	11.2	Yes	No	0	7	5
106	R:R:A116	R:R:G117	1.95	No	No	0	7	9
107	R:R:I122	R:R:V118	3.07	No	No	0	8	8
108	R:R:C119	R:R:F154	4.19	No	No	0	6	7
109	R:R:F120	R:R:L121	9.74	Yes	No	1	8	8
110	R:R:F120	R:R:L124	4.87	Yes	Yes	1	8	9
111	R:R:F241	R:R:L121	4.87	Yes	No	0	9	8
112	R:R:I122	R:R:M126	5.83	No	No	0	8	5
113	R:R:I122	R:R:L207	8.56	No	No	0	8	6
114	R:R:L124	R:R:R128	3.64	Yes	Yes	1	9	9
115	R:R:L124	R:R:L234	2.77	Yes	No	0	9	7
116	R:R:L207	R:R:S125	6.01	No	No	0	6	9
117	R:R:D127	R:R:R128	8.34	No	Yes	1	8	9
118	R:R:D127	R:R:V131	2.92	No	Yes	1	8	8
119	R:R:R128	R:R:V131	6.54	Yes	Yes	1	9	8
120	R:R:V133	R:R:Y129	2.52	No	No	0	7	8
121	R:R:Y129	R:R:Y210	3.97	No	No	0	8	4
122	R:R:R214	R:R:Y129	12.35	No	No	0	3	8
123	R:R:V131	R:R:V136	4.81	Yes	No	0	8	6
124	R:R:I132	R:R:M215	4.37	Yes	No	0	8	8
125	R:R:F218	R:R:I132	11.3	No	Yes	0	5	8
126	R:R:H227	R:R:I132	6.63	No	Yes	0	7	8
127	R:R:V133	R:R:W134	4.9	No	No	0	7	6
128	R:R:F218	R:R:V133	2.62	No	No	0	5	7
129	R:R:E137	R:R:L138	9.28	No	No	0	5	5
130	R:R:L138	R:R:R140	3.64	No	No	0	5	4
131	R:R:N143	R:R:R140	2.41	Yes	No	0	6	4
132	R:R:N144	R:R:T148	5.85	No	No	0	2	4
133	R:R:V151	R:R:W155	7.36	No	No	0	7	9
134	R:R:V152	R:R:W155	7.36	No	No	0	3	9
135	R:R:F154	R:R:I153	6.28	No	No	0	7	4
136	R:R:G162	R:R:M161	1.75	No	No	0	7	5
137	R:R:G162	R:R:P164	2.03	No	No	0	7	8
138	R:R:M163	R:R:P164	3.35	No	No	0	3	8
139	R:R:L192	R:R:P164	1.64	No	No	0	4	8
140	R:R:H165	R:R:L192	5.14	No	No	3	4	4
141	R:R:S256	R:R:V190	3.23	No	No	0	6	3
142	R:R:L252	R:R:N193	6.87	No	No	0	6	5
143	R:R:N193	R:R:S256	7.45	No	No	0	5	6
144	R:R:N197	R:R:T194	2.92	Yes	No	7	6	4
145	R:R:F253	R:R:T194	9.08	No	No	7	6	4
146	R:R:C199	R:R:K195	3.23	No	No	0	5	4
147	R:R:N249	R:R:V196	2.96	Yes	No	0	9	7
148	R:R:I198	R:R:N197	4.25	No	Yes	0	4	6
149	R:R:N197	R:R:N249	6.81	Yes	Yes	0	6	9
150	R:R:F253	R:R:N197	14.5	No	Yes	7	6	6
151	R:R:C199	R:R:I198	6.55	No	No	0	5	4
152	R:R:L202	R:R:Y201	2.34	No	No	0	5	9
153	R:R:A242	R:R:Y201	4	No	No	0	6	9
154	R:R:F246	R:R:Y201	28.88	No	No	0	5	9
155	R:R:A203	R:R:P204	1.87	No	No	0	6	9
156	R:R:F241	R:R:P204	2.89	Yes	No	0	9	9
157	R:R:I205	R:R:M208	4.37	No	No	0	6	8
158	R:R:L207	R:R:Y210	7.03	No	No	0	6	4
159	R:R:M208	R:R:V238	12.17	No	No	0	8	8
160	R:R:A242	R:R:M208	3.22	No	No	0	6	8
161	R:R:T211	R:R:Y210	9.99	No	No	0	8	4
162	R:R:M215	R:R:T211	3.01	No	No	0	8	8
163	R:R:V216	R:R:Y212	7.57	No	No	0	5	9
164	R:R:L231	R:R:Y212	2.34	Yes	No	0	6	9
165	R:R:L235	R:R:Y212	14.07	No	No	0	4	9
166	R:R:N213	R:R:R214	6.03	No	No	0	3	3
167	R:R:L231	R:R:M215	7.07	Yes	No	0	6	8
168	R:R:N221	R:R:R217	8.44	No	No	0	3	3
169	R:R:I219	R:R:L231	2.85	No	Yes	0	8	6
170	R:R:G224	R:R:Y222	2.9	No	No	0	3	4
171	R:R:W226	R:R:Y222	1.93	No	No	0	3	4
172	R:R:G224	R:R:K225	1.74	No	No	0	3	3
173	R:R:Q229	R:R:T230	5.67	No	No	0	7	8
174	R:R:Q229	R:R:Q300	3.84	No	No	0	7	6
175	R:R:H232	R:R:L231	2.57	No	Yes	0	5	6
176	R:R:V233	R:R:V297	8.02	No	No	0	8	7
177	R:R:L235	R:R:V239	2.98	No	No	0	4	5
178	R:R:S240	R:R:V237	1.62	No	Yes	0	6	8
179	R:R:I293	R:R:V237	4.61	No	Yes	0	8	8
180	R:R:S243	R:R:V239	1.62	No	No	0	4	5
181	R:R:F241	R:R:W245	6.01	Yes	Yes	0	9	9
182	R:R:F241	R:R:R286	10.69	Yes	No	0	9	9
183	R:R:F244	R:R:W245	5.01	No	Yes	0	8	9
184	R:R:F244	R:R:L282	3.65	No	No	0	8	7
185	R:R:F244	R:R:R286	16.03	No	No	0	8	9
186	R:R:F248	R:R:W245	4.01	No	Yes	0	7	9
187	R:R:N249	R:R:W245	3.39	Yes	Yes	0	9	9
188	R:R:F246	R:R:P247	4.33	No	No	0	5	9
189	R:R:F246	R:R:L250	20.7	No	No	0	5	5
190	R:R:F248	R:R:L252	3.65	No	No	0	7	6
191	R:R:F248	R:R:G279	4.52	No	No	0	7	7
192	R:R:L252	R:R:N249	13.73	No	Yes	0	6	9
193	R:R:A251	R:R:C275	3.61	No	No	0	5	5
194	R:R:F253	R:R:L254	3.65	No	No	0	6	5
195	R:R:I257	R:R:L254	2.85	No	No	0	4	5
196	R:R:E255	R:R:I272	17.76	No	No	0	5	5
197	R:R:F274	R:R:N270	3.62	No	No	0	2	2
198	R:R:L276	R:R:Q280	9.32	No	No	0	4	5
199	R:R:V278	R:R:Y277	5.05	No	No	0	5	5
200	R:R:G279	R:R:V278	3.68	No	No	0	7	5
201	R:R:L282	R:R:V278	2.98	No	No	0	7	5
202	R:R:L282	R:R:V285	2.98	No	No	0	7	5
203	R:R:N290	R:R:R286	10.85	No	No	0	9	9
204	R:R:C288	R:R:L289	4.76	No	No	2	8	7
205	R:R:N290	R:R:P291	1.63	No	No	0	9	9
206	R:R:G292	R:R:I295	1.76	No	No	0	6	8
207	R:R:M301	R:R:Y294	4.79	No	No	0	9	9
208	R:R:L296	R:R:V297	2.98	No	No	0	8	7
209	R:R:G298	R:R:V297	1.84	No	No	0	8	7
210	R:R:G298	R:R:T299	1.82	No	No	0	8	6
211	R:R:G298	R:R:Q300	4.93	No	No	0	8	6
212	R:R:D304	R:R:K303	9.68	No	No	0	5	4
213	R:R:M305	R:R:W306	3.49	No	No	0	6	2
214	R:R:V233	R:R:V237	1.6	No	Yes	0	8	8
215	R:R:V238	R:R:V239	1.6	No	No	0	8	5
216	R:R:T45	R:R:V49	1.59	No	No	0	5	3
217	R:R:A147	R:R:N143	1.56	No	Yes	0	8	6
218	R:R:I112	R:R:V159	1.54	No	No	0	5	2
219	R:R:I132	R:R:V131	1.54	Yes	Yes	0	8	8
220	R:R:I156	R:R:V152	1.54	No	No	0	4	3
221	R:R:K62	R:R:S64	1.53	No	No	0	5	7
222	R:R:H94	R:R:P95	1.53	No	No	0	5	4
223	R:R:M305	R:R:T54	1.51	No	Yes	0	6	7
224	R:R:L234	R:R:V237	1.49	No	Yes	0	7	8
225	R:R:L235	R:R:V236	1.49	No	No	0	4	6
226	R:R:N139	R:R:V141	1.48	No	No	0	4	4
227	R:R:L35	R:R:T33	1.47	No	No	0	5	5
228	R:R:L268	R:R:T267	1.47	No	No	0	3	1
229	R:R:I272	R:R:I273	1.47	No	No	0	5	4
230	R:R:K225	R:R:M228	1.44	No	No	0	3	4
231	R:R:I112	R:R:L79	1.43	No	No	0	5	6
232	R:R:I156	R:R:L160	1.43	No	No	0	4	3
233	R:R:G135	R:R:W134	1.41	No	No	0	8	6
234	R:R:L157	R:R:M161	1.41	No	No	0	3	5
235	R:R:K145	R:R:N144	1.4	No	No	0	3	2
236	R:R:L106	R:R:L84	1.38	No	Yes	0	5	8
237	R:R:N143	R:R:N144	1.36	Yes	No	0	6	2
238	R:R:E89	R:R:K92	1.35	No	No	0	5	4
239	R:R:E255	R:R:L254	1.33	No	No	0	5	5
240	R:R:E255	R:R:L268	1.33	No	No	0	5	3
241	R:R:C41	R:R:W38	1.31	No	No	0	7	3
242	R:R:C149	R:R:W150	1.31	No	No	0	2	5
243	R:R:A147	R:R:W150	1.3	No	No	0	8	5
244	R:R:E25	R:R:Q28	1.27	No	No	0	4	4
245	R:R:K145	R:R:R142	1.24	No	No	0	3	7
246	R:R:F154	R:R:N123	1.21	No	No	0	7	7
247	R:R:H94	R:R:Y90	1.09	No	No	0	5	5
248	R:R:F86	R:R:F87	1.07	No	No	0	7	6
249	R:R:R59	R:R:Y58	1.03	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y27	8.116	5	4	5
2	R:R:F30	9.845	4	4	2
3	R:R:V43	3.965	4	2	6
4	R:R:L47	5.066	5	2	7
5	R:R:T54	4.1075	4	0	7
6	R:R:Y58	7.3525	4	0	4
7	R:R:D67	4.4825	4	5	7
8	R:R:Y69	14.786	5	1	7
9	R:R:I80	5.17333	6	6	7
10	R:R:L84	7.8675	4	0	8
11	R:R:Y111	12.185	4	3	5
12	R:R:F115	6.0475	4	0	7
13	R:R:F120	13.7483	6	1	8
14	R:R:L124	7.546	5	1	9
15	R:R:R128	5.29	4	1	9
16	R:R:V131	3.9525	4	1	8
17	R:R:I132	5.96	4	0	8
18	R:R:N143	2.1475	4	0	6
19	R:R:N197	7.12	4	7	6
20	R:R:L231	3.7075	4	0	6
21	R:R:V237	2.33	4	0	8
22	R:R:F241	6.115	4	0	9
23	R:R:W245	4.605	4	0	9
24	R:R:N249	6.7225	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F30	R:R:Y27	50.9307	6.19	Yes	Yes	4	2	5
2	R:R:L88	R:R:Y27	34.3469	2.34	No	Yes	0	7	5
3	R:R:F30	R:R:Y277	59.845	12.38	Yes	No	0	2	5
4	R:R:E31	R:R:L88	31.9177	9.28	No	No	0	4	7
5	R:R:E31	R:R:K92	31.7648	5.4	No	No	0	4	4
6	R:R:I42	R:R:V43	11.4362	3.07	No	Yes	0	4	6
7	R:R:L47	R:R:V43	10.6611	2.98	Yes	Yes	2	7	6
8	R:R:L47	R:R:P291	14.9135	14.78	Yes	No	0	7	9
9	R:R:N290	R:R:P291	22.3538	1.63	No	No	0	9	9
10	R:R:N290	R:R:R286	18.1396	10.85	No	No	0	9	9
11	R:R:F244	R:R:R286	29.6905	16.03	No	No	0	8	9
12	R:R:F244	R:R:L282	44.6094	3.65	No	No	0	8	7
13	R:R:L282	R:R:V278	40.5972	2.98	No	No	0	7	5
14	R:R:V278	R:R:Y277	62.0012	5.05	No	No	0	5	5
15	R:R:G44	R:R:N48	16.9059	1.7	No	No	0	9	9
16	R:R:L78	R:R:N48	25.0669	10.98	No	No	0	8	9
17	R:R:L78	R:R:V82	23.9041	4.47	No	No	0	8	5
18	R:R:G83	R:R:V82	22.7414	3.68	No	No	0	7	5
19	R:R:C109	R:R:G83	21.606	1.96	No	No	0	4	7
20	R:R:C109	R:R:I80	17.7848	1.64	No	Yes	0	4	7
21	R:R:I80	R:R:L84	13.314	5.71	Yes	Yes	0	7	8
22	R:R:D77	R:R:N290	12.7081	4.04	No	No	0	9	9
23	R:R:G279	R:R:V278	24.1771	3.68	No	No	0	7	5
24	R:R:F248	R:R:G279	25.0505	4.52	No	No	0	7	7
25	R:R:F248	R:R:W245	26.4152	4.01	No	Yes	0	7	9
26	R:R:F241	R:R:W245	59.179	6.01	Yes	Yes	0	9	9
27	R:R:F241	R:R:L121	72.4166	4.87	Yes	No	0	9	8
28	R:R:F120	R:R:L121	70.1294	9.74	Yes	No	1	8	8
29	R:R:F120	R:R:L124	98.9301	4.87	Yes	Yes	1	8	9
30	R:R:L124	R:R:R128	100	3.64	Yes	Yes	1	9	9
31	R:R:D127	R:R:R128	38.8176	8.34	No	Yes	1	8	9
32	R:R:D127	R:R:P65	45.0953	1.61	No	No	0	8	7
33	R:R:P65	R:R:S64	26.0331	1.78	No	No	0	7	7
34	R:R:D67	R:R:S64	22.7032	4.42	Yes	No	0	7	7
35	R:R:D67	R:R:I55	10.5301	5.6	Yes	No	0	7	7
36	R:R:I52	R:R:L56	10.5901	4.28	No	No	0	7	4
37	R:R:F244	R:R:W245	28.0638	5.01	No	Yes	0	8	9
38	R:R:F241	R:R:R286	25.5472	10.69	Yes	No	0	9	9
39	R:R:P291	R:R:V51	13.6689	3.53	No	No	0	9	9
40	R:R:M301	R:R:V51	15.241	4.56	No	No	0	9	9
41	R:R:M301	R:R:T54	32.9221	6.02	No	Yes	0	9	7
42	R:R:D304	R:R:T54	20.476	2.89	No	Yes	0	5	7
43	R:R:D304	R:R:Y58	15.4211	18.39	No	Yes	0	5	4
44	R:R:N143	R:R:P65	19.3297	3.26	Yes	No	0	6	7
45	R:R:S66	R:R:Y69	11.1742	5.09	No	Yes	1	8	7
46	R:R:F120	R:R:I70	13.7453	7.54	Yes	No	1	8	8
47	R:R:I70	R:R:Y294	29.5049	3.63	No	No	0	8	9
48	R:R:M301	R:R:Y294	27.5452	4.79	No	No	0	9	9
49	R:R:D77	R:R:L73	33.73	5.43	No	No	0	9	9
50	R:R:E89	R:R:K92	29.1774	1.35	No	No	0	5	4
51	R:R:E89	R:R:F86	16.0762	9.33	No	No	0	5	7
52	R:R:F86	R:R:F87	13.4232	1.07	No	No	0	7	6
53	R:R:F87	R:R:G105	10.7593	3.01	No	No	0	6	4
54	R:R:E89	R:R:Y90	10.7593	5.61	No	No	0	5	5
55	R:R:R128	R:R:V131	70.708	6.54	Yes	Yes	1	9	8
56	R:R:I132	R:R:V131	75.9594	1.54	Yes	Yes	0	8	8
57	R:R:I132	R:R:M215	62.8637	4.37	Yes	No	0	8	8
58	R:R:M215	R:R:T211	35.2749	3.01	No	No	0	8	8
59	R:R:T211	R:R:Y210	33.7464	9.99	No	No	0	8	4
60	R:R:L207	R:R:Y210	32.5618	7.03	No	No	0	6	4
61	R:R:I122	R:R:L207	29.3193	8.56	No	No	0	8	6
62	R:R:I122	R:R:V118	26.0331	3.07	No	No	0	8	8
63	R:R:L114	R:R:V118	24.3736	2.98	No	No	0	8	8
64	R:R:F115	R:R:L114	22.7032	6.09	Yes	No	0	7	8
65	R:R:F115	R:R:Y111	10.5956	4.13	Yes	Yes	0	7	5
66	R:R:L124	R:R:L234	19.5153	2.77	Yes	No	0	9	7
67	R:R:F218	R:R:I132	11.3434	11.3	No	Yes	0	5	8
68	R:R:N249	R:R:W245	30.3019	3.39	Yes	Yes	0	9	9
69	R:R:N197	R:R:N249	25.5418	6.81	Yes	Yes	0	6	9
70	R:R:F253	R:R:N197	15.8906	14.5	No	Yes	7	6	6
71	R:R:L231	R:R:M215	30.946	7.07	Yes	No	0	6	8
72	R:R:L231	R:R:Y212	26.0331	2.34	Yes	No	0	6	9
73	R:R:L235	R:R:Y212	22.7032	14.07	No	No	0	4	9
74	R:R:L235	R:R:V239	19.3297	2.98	No	No	0	4	5
75	R:R:V238	R:R:V239	15.9124	1.6	No	No	0	8	5
76	R:R:M208	R:R:V238	14.1875	12.17	No	No	0	8	8
77	R:R:A242	R:R:M208	10.7047	3.22	No	No	0	6	8
78	R:R:L234	R:R:V237	17.9486	1.49	No	Yes	0	7	8
79	R:R:V233	R:R:V237	13.183	1.6	No	Yes	0	8	8
80	R:R:V233	R:R:V297	11.5727	8.02	No	No	0	8	7
81	R:R:F253	R:R:L254	13.98	3.65	No	No	0	6	5
82	R:R:E255	R:R:L254	10.0388	1.33	No	No	0	5	5
83	R:R:G44	R:R:L47	10.3554	1.71	No	Yes	0	9	7
84	R:R:D77	R:R:N48	31.9013	2.69	No	No	0	9	9
85	R:R:F120	R:R:L73	31.9122	28.01	Yes	No	1	8	9
86	R:R:I70	R:R:Y69	17.9104	9.67	No	Yes	1	8	7
87	R:R:R128	R:R:S66	10.4755	2.64	Yes	No	1	9	8
88	R:R:L124	R:R:Y69	11.6709	23.45	Yes	Yes	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7RKY_nogp

PDB Summary
PDB	7RKY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.61
Number of Linked Nodes	231
Number of Links	249
Number of Hubs	24
Number of Links mediated by Hubs	91
Number of Communities	7
Number of Nodes involved in Communities	30
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	39796
Length Of Smallest Path	3
Average Path Length	14.7919
Length of Longest Path	35
Minimum Path Strength	1.305
Average Path Strength	5.81585
Maximum Path Strength	28.96
Minimum Path Correlation	0.74
Average Path Correlation	0.990252
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	11.7647
Average % Of Corr. Nodes	91.1384
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.1723
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • chemotaxis • response to stimulus • response to external stimulus • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cellular process • cell motility • locomotion • regulation of biological process • regulation of cellular process • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • immune response • immune system process • virion component • cellular anatomical structure • membrane • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Galpha insert domain-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Galpha insert domain-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GDP
PDB Residues	O:O:?1
Environment Details	Open EMBL-EBI Page
Code	GDP
Name	Guanosine-5'-Diphosphate
Synonyms	Guanosine-5'-Diphosphate
Identifier
Formula	C10 H15 N5 O11 P2
Molecular Weight	443.201
SMILES
PubChem	135398619
Formal Charge	0
Total Atoms	43
Total Chiral Atoms	4
Total Bonds	45
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P09703
Sequence	>7RKY_nogp_Chain_R E I Y Q L F E Y T R L G V W L M C I V G T F L N V L V I T T I L Y Y R R K K K S P S D T Y I C N L A V A D L L I V V G L P F F L E Y A K H H P S R E V V C S G L N A C F Y I C L F A G V C F L I N L S M D R Y C V I V W G V E L N R V R N N K R A T C W V V I F W I L A V L M G M P H Y V F L N T K V N I C G Y L A P I A L M A Y T Y N R M V R F I I N Y V G K W H M Q T L H V L L V V V V S F A S F W F P F N L A L F L E S I D T L Q N V I I F C L Y V G Q F L A Y V R A C L N P G I Y I L V G T Q M R K D M W T T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7RKX	A	Other	Unclassified	US27	Human betaherpesvirus 5	-	-	Gi1/β1/γ2	3.1	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKX (No Gprot)	A	Other	Unclassified	US27	Human betaherpesvirus 5	-	-		3.1	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKY	A	Other	Unclassified	US27	Human betaherpesvirus 5	-	GDP	Gi1/β1/γ2	3.8	2022-01-26	doi.org/10.1126/sciadv.abl5442
	7RKY (No Gprot)	A	Other	Unclassified	US27	Human betaherpesvirus 5	-	GDP		3.8	2022-01-26	doi.org/10.1126/sciadv.abl5442

there is no ligand in network 7RKY_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.