Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8FN0 | A | Peptide | Neurotensin | NTS1 | Rattus Norvegicus | Neurotensin/neuromedin N | PubChem 118610427 | chim(NtGi1-Go)/Beta1/Gamma2 | 2.89 | 2023-03-29 | 10.1021/acs.biochem.3c00029 |
![](/psngpcr/ligands/SRW/SRW_8FN0_W_W_1.png)
A 2D representation of the interactions of SRW in 8FN0 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:H103 | R:R:L89 | 5.14 | 0 | No | No | 8 | 7 | 1 | 2 | R:R:H103 | R:R:V102 | 4.15 | 0 | No | Yes | 8 | 8 | 1 | 2 | R:R:E166 | R:R:V102 | 8.56 | 4 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:R167 | R:R:V102 | 6.54 | 4 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:C351 | R:R:V102 | 13.67 | 4 | No | Yes | 4 | 8 | 1 | 2 | R:R:H103 | W:W:?1 | 7.5 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:L106 | R:R:L163 | 4.15 | 4 | No | No | 8 | 9 | 1 | 1 | R:R:L106 | R:R:Y369 | 26.96 | 4 | No | No | 8 | 9 | 1 | 1 | R:R:L106 | W:W:?1 | 5.38 | 4 | No | Yes | 8 | 0 | 1 | 0 | R:R:L109 | R:R:Y369 | 4.69 | 0 | No | No | 9 | 9 | 2 | 1 | R:R:L163 | W:W:?1 | 12.56 | 4 | No | Yes | 9 | 0 | 1 | 0 | R:R:I253 | R:R:S164 | 4.64 | 0 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:N257 | R:R:S164 | 5.96 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:S164 | W:W:?1 | 3.89 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:E166 | R:R:R167 | 12.79 | 4 | Yes | Yes | 9 | 9 | 2 | 1 | A:A:L348 | R:R:R167 | 4.86 | 4 | Yes | Yes | 8 | 9 | 1 | 1 | A:A:C351 | R:R:R167 | 11.14 | 4 | No | Yes | 4 | 9 | 1 | 1 | R:R:R167 | W:W:?1 | 19.68 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:L348 | R:R:I171 | 5.71 | 4 | Yes | No | 8 | 8 | 1 | 2 | R:R:L310 | R:R:N257 | 6.87 | 0 | No | No | 8 | 9 | 1 | 2 | R:R:L310 | W:W:?1 | 7.18 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:V313 | W:W:?1 | 11.59 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:Y369 | W:W:?1 | 9.88 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:I344 | A:A:L348 | 5.71 | 4 | Yes | Yes | 7 | 8 | 2 | 1 | A:A:L348 | A:A:L353 | 22.14 | 4 | Yes | No | 8 | 6 | 1 | 1 | A:A:L348 | W:W:?1 | 7.18 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | A:A:C351 | W:W:?1 | 12.34 | 4 | No | Yes | 4 | 0 | 1 | 0 | A:A:G352 | W:W:?1 | 11.09 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:L353 | W:W:?1 | 39.47 | 4 | No | Yes | 6 | 0 | 1 | 0 | R:R:L256 | R:R:S164 | 3 | 0 | Yes | Yes | 7 | 9 | 2 | 1 | A:A:L353 | R:R:V372 | 2.98 | 4 | No | No | 6 | 7 | 1 | 2 | A:A:L348 | R:R:L303 | 2.77 | 4 | Yes | No | 8 | 8 | 1 | 2 | R:R:A170 | R:R:R167 | 1.38 | 0 | No | Yes | 8 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 12.31 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 27.00 |
| ![](/psngpcr/ligands/SRW/SRW_8FN0_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/SRW/SRW_8FN0_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JPB | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin 8-13 | PubChem 118610427; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | 10.1038/s41586-023-06395-9 |
![](/psngpcr/ligands/SRW/SRW_8JPB_W_W_1.png)
A 2D representation of the interactions of SRW in 8JPB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | K:K:L4 | K:K:L8 | 5.54 | 3 | No | No | 9 | 9 | 1 | 1 | K:K:L4 | R:R:G301 | 5.13 | 3 | No | No | 9 | 8 | 1 | 2 | K:K:L4 | W:W:?1 | 7.18 | 3 | No | Yes | 9 | 0 | 1 | 0 | K:K:E5 | R:R:S368 | 11.5 | 3 | No | No | 9 | 8 | 1 | 1 | K:K:E5 | R:R:N370 | 5.26 | 3 | No | No | 9 | 7 | 1 | 2 | K:K:E5 | W:W:?1 | 18.03 | 3 | No | Yes | 9 | 0 | 1 | 0 | K:K:L8 | W:W:?1 | 4.49 | 3 | No | Yes | 9 | 0 | 1 | 0 | R:R:F371 | R:R:T84 | 5.19 | 3 | Yes | No | 8 | 9 | 1 | 2 | R:R:F371 | R:R:T87 | 3.89 | 3 | Yes | No | 8 | 7 | 1 | 2 | R:R:R166 | R:R:V101 | 6.54 | 3 | Yes | No | 9 | 8 | 1 | 2 | R:R:L105 | R:R:L162 | 6.92 | 3 | No | No | 8 | 9 | 1 | 1 | R:R:L105 | R:R:Y364 | 11.72 | 3 | No | Yes | 8 | 9 | 1 | 1 | R:R:L105 | W:W:?1 | 3.59 | 3 | No | Yes | 8 | 0 | 1 | 0 | R:R:L108 | R:R:V159 | 4.47 | 3 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:L108 | R:R:N360 | 6.87 | 3 | Yes | No | 9 | 9 | 2 | 2 | R:R:L108 | R:R:Y364 | 3.52 | 3 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:I252 | R:R:V159 | 4.61 | 3 | No | Yes | 8 | 8 | 2 | 1 | R:R:F312 | R:R:V159 | 3.93 | 3 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:V159 | W:W:?1 | 3.86 | 3 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:L162 | W:W:?1 | 12.56 | 3 | No | Yes | 9 | 0 | 1 | 0 | R:R:I170 | R:R:R166 | 5.01 | 3 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:R166 | W:W:?1 | 39.37 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:I170 | W:W:?1 | 4.63 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:F312 | R:R:I252 | 3.77 | 3 | Yes | No | 9 | 8 | 2 | 2 | R:R:V304 | R:R:V367 | 4.81 | 0 | No | No | 8 | 7 | 2 | 1 | R:R:V308 | W:W:?1 | 10.62 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:N360 | R:R:Y364 | 3.49 | 3 | No | Yes | 9 | 9 | 2 | 1 | R:R:F371 | R:R:Y364 | 4.13 | 3 | Yes | Yes | 8 | 9 | 1 | 1 | R:R:Y364 | W:W:?1 | 6.84 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:F371 | R:R:N365 | 4.83 | 3 | Yes | No | 8 | 7 | 1 | 2 | R:R:F375 | R:R:N365 | 18.12 | 3 | Yes | No | 7 | 7 | 2 | 2 | R:R:V367 | W:W:?1 | 6.76 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:S368 | W:W:?1 | 4.87 | 3 | No | Yes | 8 | 0 | 1 | 0 | R:R:F371 | R:R:F375 | 5.36 | 3 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:F371 | W:W:?1 | 7.1 | 3 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:C171 | R:R:I170 | 3.27 | 3 | Yes | Yes | 7 | 9 | 2 | 1 | R:R:I170 | R:R:L263 | 2.85 | 3 | Yes | No | 9 | 8 | 1 | 2 | R:R:A169 | R:R:R166 | 1.38 | 0 | No | Yes | 8 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.99 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/SRW/SRW_8JPB_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/SRW/SRW_8JPB_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JPC | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin 8-13 | PubChem 118610427; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | 10.1038/s41586-023-06395-9 |
![](/psngpcr/ligands/SRW/SRW_8JPC_W_W_1.png)
A 2D representation of the interactions of SRW in 8JPC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F371 | R:R:T84 | 3.89 | 0 | Yes | No | 8 | 9 | 1 | 2 | R:R:F371 | R:R:T87 | 3.89 | 0 | Yes | No | 8 | 7 | 1 | 2 | R:R:H102 | R:R:L88 | 10.29 | 8 | No | No | 8 | 7 | 1 | 2 | R:R:L105 | R:R:L88 | 4.15 | 8 | Yes | No | 8 | 7 | 1 | 2 | R:R:F371 | R:R:L88 | 3.65 | 0 | Yes | No | 8 | 7 | 1 | 2 | K:K:E5 | R:R:H102 | 4.92 | 8 | No | No | 9 | 8 | 1 | 1 | R:R:H102 | W:W:?1 | 6.67 | 8 | No | Yes | 8 | 0 | 1 | 0 | R:R:L105 | R:R:L162 | 4.15 | 8 | Yes | No | 8 | 9 | 1 | 1 | R:R:L105 | R:R:Y364 | 10.55 | 8 | Yes | No | 8 | 9 | 1 | 2 | R:R:L105 | W:W:?1 | 6.28 | 8 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:L108 | R:R:V159 | 4.47 | 8 | Yes | No | 9 | 8 | 2 | 1 | R:R:L108 | R:R:Y364 | 3.52 | 8 | Yes | No | 9 | 9 | 2 | 2 | R:R:I252 | R:R:V159 | 4.61 | 0 | No | No | 8 | 8 | 2 | 1 | R:R:V159 | W:W:?1 | 3.86 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:L162 | W:W:?1 | 8.97 | 8 | No | Yes | 9 | 0 | 1 | 0 | K:K:L8 | R:R:R166 | 3.64 | 0 | No | No | 9 | 9 | 2 | 1 | R:R:R166 | W:W:?1 | 25.98 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:I252 | R:R:N256 | 4.25 | 0 | No | No | 8 | 9 | 2 | 2 | R:R:L305 | R:R:N256 | 5.49 | 0 | No | No | 8 | 9 | 1 | 2 | R:R:V304 | R:R:V367 | 8.02 | 0 | No | No | 8 | 7 | 2 | 1 | R:R:L305 | W:W:?1 | 4.49 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:V308 | W:W:?1 | 18.34 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:V367 | W:W:?1 | 4.83 | 0 | No | Yes | 7 | 0 | 1 | 0 | K:K:D3 | R:R:S368 | 7.36 | 0 | Yes | No | 9 | 8 | 2 | 1 | R:R:S368 | W:W:?1 | 4.87 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:F371 | R:R:F375 | 5.36 | 0 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:F371 | W:W:?1 | 5.53 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | K:K:L4 | K:K:L8 | 6.92 | 0 | No | No | 9 | 9 | 1 | 2 | K:K:L4 | W:W:?1 | 8.07 | 0 | No | Yes | 9 | 0 | 1 | 0 | K:K:E5 | W:W:?1 | 11.16 | 8 | No | Yes | 9 | 0 | 1 | 0 | K:K:L4 | R:R:G301 | 3.42 | 0 | No | No | 9 | 8 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 9.09 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 22.00 |
| ![](/psngpcr/ligands/SRW/SRW_8JPC_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/SRW/SRW_8JPC_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JPF | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin | PubChem 118610427 | - | 3.02 | 2023-08-09 | 10.1038/s41586-023-06395-9 |
![](/psngpcr/ligands/SRW/SRW_8JPF_W_W_1.png)
A 2D representation of the interactions of SRW in 8JPF colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F371 | R:R:T84 | 5.19 | 0 | No | No | 8 | 9 | 1 | 2 | R:R:L105 | R:R:V101 | 4.47 | 2 | Yes | No | 8 | 8 | 1 | 2 | R:R:R166 | R:R:V101 | 13.08 | 0 | No | No | 9 | 8 | 1 | 2 | R:R:L105 | R:R:L162 | 5.54 | 2 | Yes | No | 8 | 9 | 1 | 1 | R:R:L105 | R:R:Y364 | 14.07 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | R:R:L105 | W:W:?1 | 3.59 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | R:R:L108 | R:R:V159 | 4.47 | 2 | Yes | No | 9 | 8 | 2 | 1 | R:R:L108 | R:R:Y364 | 3.52 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:I252 | R:R:V159 | 4.61 | 5 | Yes | No | 8 | 8 | 2 | 1 | R:R:V159 | W:W:?1 | 3.86 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:L162 | W:W:?1 | 13.46 | 2 | No | Yes | 9 | 0 | 1 | 0 | R:R:R166 | W:W:?1 | 30.71 | 0 | No | Yes | 9 | 0 | 1 | 0 | R:R:I170 | W:W:?1 | 4.63 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | R:R:I252 | R:R:N256 | 4.25 | 5 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:L305 | R:R:N256 | 6.87 | 0 | No | Yes | 8 | 9 | 1 | 2 | R:R:L305 | W:W:?1 | 6.28 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:V308 | W:W:?1 | 14.48 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:F371 | R:R:Y364 | 5.16 | 0 | No | Yes | 8 | 9 | 1 | 2 | R:R:V367 | W:W:?1 | 9.66 | 0 | No | Yes | 7 | 0 | 1 | 0 | R:R:F371 | W:W:?1 | 6.31 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:I170 | R:R:I259 | 2.94 | 0 | Yes | No | 9 | 9 | 1 | 2 | R:R:S368 | W:W:?1 | 2.92 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:I170 | R:R:K262 | 2.91 | 0 | Yes | No | 9 | 5 | 1 | 2 | R:R:I170 | R:R:L263 | 2.85 | 0 | Yes | No | 9 | 8 | 1 | 2 | R:R:V304 | W:W:?1 | 1.93 | 0 | No | Yes | 8 | 0 | 1 | 0 | R:R:L366 | R:R:V304 | 1.49 | 0 | No | No | 6 | 8 | 2 | 1 | R:R:N370 | R:R:S368 | 1.49 | 0 | No | No | 7 | 8 | 2 | 1 | R:R:A169 | R:R:R166 | 1.38 | 0 | No | No | 8 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 8.89 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 28.00 | Average Links Mediated by Hubs In Shell | 23.00 |
| ![](/psngpcr/ligands/SRW/SRW_8JPF_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/SRW/SRW_8JPF_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|