psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K1	R:R:Y339	15.53	No	Yes	0	0	2
2	L:L:K2	L:L:P3	3.35	Yes	Yes	1	0	0
3	L:L:K2	R:R:F326	7.44	Yes	Yes	0	0	4
4	L:L:K2	R:R:W334	12.76	Yes	Yes	1	0	4
5	L:L:P3	R:R:W334	17.57	Yes	Yes	1	0	4
6	L:L:P3	R:R:Y339	4.17	Yes	Yes	1	0	2
7	L:L:P3	R:R:Y342	12.52	Yes	Yes	1	0	4
8	L:L:P3	R:R:H343	4.58	Yes	Yes	1	0	4
9	L:L:I5	L:L:Y4	7.25	No	Yes	0	0	0
10	L:L:Y4	R:R:L54	7.03	Yes	No	0	0	5
11	L:L:Y4	R:R:H131	5.44	Yes	No	0	0	3
12	L:L:Y4	R:R:V223	7.57	Yes	No	0	0	4
13	L:L:Y4	R:R:T225	3.75	Yes	Yes	0	0	4
14	L:L:I5	R:R:F127	6.28	No	Yes	1	0	4
15	L:L:I5	R:R:Y346	6.04	No	Yes	1	0	4
16	L:L:L6	R:R:Y145	5.86	Yes	No	1	0	4
17	L:L:L6	R:R:M207	4.24	Yes	No	1	0	6
18	L:L:L6	R:R:R323	4.86	Yes	Yes	1	0	6
19	L:L:L6	R:R:F326	14.61	Yes	Yes	0	0	4
20	R:R:H132	R:R:S51	8.37	Yes	No	0	4	3
21	R:R:H132	R:R:L54	7.71	Yes	No	0	4	5
22	R:R:D55	R:R:H132	7.56	No	Yes	0	3	4
23	R:R:H131	R:R:V56	11.07	No	No	0	3	2
24	R:R:V56	R:R:Y339	6.31	No	Yes	1	2	2
25	R:R:H343	R:R:V56	20.76	Yes	No	1	4	2
26	R:R:K63	R:R:T58	9.01	No	No	0	5	1
27	R:R:T58	R:R:Y344	12.48	No	Yes	0	1	1
28	R:R:D59	R:R:Y344	4.6	No	Yes	0	3	1
29	R:R:I60	R:R:Y61	3.63	No	No	0	2	2
30	R:R:S62	R:R:Y344	3.82	No	Yes	0	3	1
31	R:R:K63	R:R:M347	5.76	No	No	0	5	3
32	R:R:V66	R:R:Y70	8.83	No	Yes	0	5	7
33	R:R:M347	R:R:V66	9.13	No	No	0	3	5
34	R:R:T67	R:R:W129	13.34	No	No	0	6	5
35	R:R:M120	R:R:Y70	3.59	Yes	Yes	0	8	7
36	R:R:L124	R:R:Y70	3.52	No	Yes	0	6	7
37	R:R:N350	R:R:Y70	3.49	No	Yes	0	6	7
38	R:R:A351	R:R:Y70	4	No	Yes	0	5	7
39	R:R:L73	R:R:T358	5.9	No	No	0	7	7
40	R:R:F74	R:R:T78	3.89	No	No	0	7	6
41	R:R:F74	R:R:M120	4.98	No	Yes	0	7	8
42	R:R:G77	R:R:T358	3.64	No	No	0	8	7
43	R:R:G80	R:R:V79	3.68	No	No	0	9	5
44	R:R:G80	R:R:P361	4.06	No	No	0	9	9
45	R:R:A109	R:R:N81	4.69	No	No	0	9	9
46	R:R:D112	R:R:N81	6.73	Yes	No	0	9	9
47	R:R:N81	R:R:P361	6.52	No	No	0	9	9
48	R:R:F375	R:R:V83	9.18	Yes	No	0	7	6
49	R:R:A109	R:R:T84	3.36	No	Yes	0	9	9
50	R:R:P361	R:R:T84	5.25	No	Yes	0	9	9
51	R:R:F371	R:R:T84	5.19	Yes	Yes	0	8	9
52	R:R:F371	R:R:T87	7.78	Yes	No	0	8	7
53	R:R:H102	R:R:L88	5.14	No	No	0	8	7
54	R:R:H102	R:R:K91	5.24	No	No	0	8	5
55	R:R:Q95	R:R:R182	4.67	No	Yes	0	4	3
56	R:R:K177	R:R:L97	7.05	No	No	0	4	8
57	R:R:H102	R:R:Q98	4.95	No	No	0	8	7
58	R:R:S99	R:R:Y103	8.9	No	Yes	4	8	5
59	R:R:R182	R:R:S99	6.59	Yes	No	4	3	8
60	R:R:E165	R:R:T100	7.06	Yes	No	0	8	7
61	R:R:T100	R:R:T185	9.42	No	No	0	7	7
62	R:R:E165	R:R:V101	4.28	Yes	No	0	8	8
63	R:R:R182	R:R:Y103	4.12	Yes	Yes	4	3	5
64	R:R:K186	R:R:Y103	3.58	No	Yes	0	3	5
65	R:R:H104	R:R:S161	5.58	Yes	No	0	8	7
66	R:R:E165	R:R:H104	7.39	Yes	Yes	0	8	8
67	R:R:F188	R:R:H104	4.53	No	Yes	0	6	8
68	R:R:H104	R:R:I189	11.93	Yes	No	0	8	7
69	R:R:L105	R:R:L162	4.15	No	No	0	8	9
70	R:R:L105	R:R:Y364	17.58	No	No	0	8	9
71	R:R:N158	R:R:S107	8.94	Yes	No	5	8	9
72	R:R:S107	R:R:W193	6.18	No	Yes	5	9	9
73	R:R:L108	R:R:N360	8.24	No	No	0	9	9
74	R:R:L110	R:R:W193	5.69	No	Yes	0	6	9
75	R:R:S111	R:R:T155	6.4	No	No	0	8	9
76	R:R:N158	R:R:S111	4.47	Yes	No	0	8	8
77	R:R:D112	R:R:T155	7.23	Yes	No	0	9	9
78	R:R:D112	R:R:S357	4.42	Yes	No	0	9	9
79	R:R:D112	R:R:N360	6.73	Yes	No	0	9	9
80	R:R:L113	R:R:L117	6.92	No	No	3	7	5
81	R:R:C151	R:R:T115	3.38	No	No	0	7	7
82	R:R:L116	R:R:S357	9.01	No	No	0	7	9
83	R:R:L118	R:R:L147	4.15	No	No	0	5	5
84	R:R:A119	R:R:R148	4.15	No	No	0	7	7
85	R:R:A119	R:R:Y354	4	No	Yes	0	7	7
86	R:R:M120	R:R:Y354	8.38	Yes	Yes	0	8	7
87	R:R:N126	R:R:V122	4.43	Yes	No	0	5	6
88	R:R:V122	R:R:Y144	16.4	No	No	0	6	6
89	R:R:E123	R:R:F127	5.83	Yes	Yes	0	6	4
90	R:R:E123	R:R:Y144	4.49	Yes	No	0	6	6
91	R:R:E123	R:R:N350	3.94	Yes	No	0	6	6
92	R:R:E123	R:R:Y354	13.47	Yes	Yes	0	6	7
93	R:R:N126	R:R:Y125	3.49	Yes	No	0	5	5
94	R:R:V130	R:R:Y125	7.57	No	No	0	5	5
95	R:R:F127	R:R:N126	3.62	Yes	Yes	1	4	5
96	R:R:N126	R:R:W134	15.82	Yes	Yes	1	5	8
97	R:R:F127	R:R:W134	4.01	Yes	Yes	1	4	8
98	R:R:F127	R:R:Y145	6.19	Yes	No	1	4	4
99	R:R:F127	R:R:Y346	10.32	Yes	Yes	1	4	4
100	R:R:H132	R:R:P133	7.63	Yes	No	0	4	5
101	R:R:G220	R:R:H132	4.77	No	Yes	0	5	4
102	R:R:C141	R:R:W134	3.92	No	Yes	1	9	8
103	R:R:C224	R:R:W134	19.59	No	Yes	1	9	8
104	R:R:D138	R:R:E209	3.9	No	No	0	3	5
105	R:R:C141	R:R:G208	3.92	No	No	0	9	4
106	R:R:C141	R:R:C224	7.28	No	No	1	9	9
107	R:R:L204	R:R:R142	3.64	No	No	0	5	7
108	R:R:G208	R:R:R142	4.5	No	No	0	4	7
109	R:R:R148	R:R:Y144	10.29	No	No	0	7	6
110	R:R:M207	R:R:Y145	13.17	No	No	1	6	4
111	R:R:A200	R:R:F146	4.16	No	No	0	7	6
112	R:R:F146	R:R:L204	9.74	No	No	0	6	5
113	R:R:R148	R:R:Y319	4.12	No	Yes	0	7	6
114	R:R:D149	R:R:M203	12.48	No	No	0	5	5
115	R:R:D149	R:R:N240	4.04	No	No	1	5	6
116	R:R:D149	R:R:R323	3.57	No	Yes	1	5	6
117	R:R:F353	R:R:T152	3.89	No	No	0	7	7
118	R:R:L199	R:R:Y153	14.07	No	Yes	1	6	7
119	R:R:N240	R:R:Y153	12.79	No	Yes	1	6	7
120	R:R:M243	R:R:Y153	3.59	No	Yes	1	5	7
121	R:R:S244	R:R:Y153	7.63	No	Yes	0	6	7
122	R:R:A154	R:R:W193	5.19	No	Yes	0	7	9
123	R:R:A154	R:R:S196	3.42	No	No	0	7	8
124	R:R:T155	R:R:W316	4.85	No	Yes	0	9	8
125	R:R:A156	R:R:P248	3.74	No	Yes	0	8	9
126	R:R:I192	R:R:N158	4.25	No	Yes	0	7	8
127	R:R:N158	R:R:W193	6.78	Yes	Yes	5	8	9
128	R:R:I252	R:R:V159	4.61	No	No	0	8	8
129	R:R:L162	R:R:R166	8.5	No	No	0	9	9
130	R:R:L255	R:R:S163	4.5	No	No	0	7	9
131	R:R:N256	R:R:S163	8.94	Yes	No	0	9	9
132	R:R:C171	R:R:Y167	6.72	No	Yes	0	7	8
133	R:R:L255	R:R:Y167	7.03	No	Yes	0	7	8
134	R:R:I258	R:R:Y167	3.63	No	Yes	0	5	8
135	R:R:I259	R:R:Y167	3.63	No	Yes	0	9	8
136	R:R:I170	R:R:I259	4.42	No	No	0	9	9
137	R:R:C171	R:R:K262	3.23	No	No	0	7	5
138	R:R:F174	R:R:P173	5.78	No	No	0	7	8
139	R:R:L199	R:R:M243	7.07	No	No	1	6	5
140	R:R:F205	R:R:V201	3.93	No	No	0	4	5
141	R:R:P202	R:R:V236	3.53	No	No	0	7	6
142	R:R:T206	R:R:V236	6.35	No	No	0	5	6
143	R:R:M207	R:R:P226	10.06	No	Yes	0	6	5
144	R:R:E209	R:R:L222	7.95	No	No	0	5	4
145	R:R:Q210	R:R:R212	10.51	No	No	2	1	1
146	R:R:Q210	R:R:T225	5.67	No	Yes	2	1	4
147	R:R:Q210	R:R:T227	7.09	No	No	0	1	3
148	R:R:N211	R:R:S213	5.96	No	No	0	2	1
149	R:R:L222	R:R:N211	5.49	No	No	0	4	2
150	R:R:R212	R:R:V223	5.23	No	No	0	1	4
151	R:R:R212	R:R:T225	15.52	No	Yes	2	1	4
152	R:R:P226	R:R:T225	3.5	Yes	Yes	0	5	4
153	R:R:P226	R:R:V233	5.3	Yes	No	0	5	5
154	R:R:F326	R:R:P226	4.33	Yes	Yes	0	4	5
155	R:R:I228	R:R:T232	9.12	No	No	0	5	4
156	R:R:K234	R:R:Q238	6.78	No	No	6	4	5
157	R:R:K234	R:R:Y328	4.78	No	Yes	6	4	5
158	R:R:C327	R:R:I237	8.18	No	No	0	3	6
159	R:R:Q238	R:R:Y328	6.76	No	Yes	6	5	5
160	R:R:N240	R:R:R323	13.26	No	Yes	1	6	6
161	R:R:H320	R:R:T241	9.58	Yes	No	0	7	6
162	R:R:F242	R:R:I246	11.3	No	No	0	5	5
163	R:R:H320	R:R:S244	5.58	Yes	No	0	7	6
164	R:R:F245	R:R:I246	3.77	No	No	0	8	5
165	R:R:F245	R:R:L317	7.31	No	No	0	8	7
166	R:R:F245	R:R:H320	6.79	No	Yes	0	8	7
167	R:R:F247	R:R:P248	4.33	No	Yes	0	6	9
168	R:R:F312	R:R:P248	5.78	Yes	Yes	0	9	9
169	R:R:F312	R:R:M249	4.98	Yes	No	0	9	6
170	R:R:I252	R:R:N256	5.66	No	Yes	0	8	9
171	R:R:F312	R:R:I252	7.54	Yes	No	0	9	8
172	R:R:L305	R:R:N256	6.87	No	Yes	0	8	9
173	R:R:N256	R:R:V309	4.43	Yes	No	0	9	8
174	R:R:K262	R:R:M266	7.2	No	No	0	5	6
175	R:R:L263	R:R:L298	5.54	No	Yes	0	8	7
176	R:R:L298	R:R:V267	4.47	Yes	No	0	7	6
177	R:R:R299	R:R:V267	3.92	No	No	0	5	6
178	R:R:A270	R:R:R294	5.53	No	No	0	5	4
179	R:R:C277	R:R:T278	6.76	No	No	0	3	4
180	R:R:G281	R:R:P292	4.06	No	No	0	5	3
181	R:R:R306	R:R:V302	5.23	No	No	0	5	7
182	R:R:L363	R:R:V304	4.47	No	Yes	0	8	8
183	R:R:F312	R:R:W316	7.02	Yes	Yes	0	9	8
184	R:R:C315	R:R:V355	3.42	No	No	0	9	5
185	R:R:C315	R:R:S356	5.16	No	No	0	9	9
186	R:R:F353	R:R:W316	8.02	No	Yes	0	7	8
187	R:R:S356	R:R:W316	8.65	No	Yes	0	9	8
188	R:R:L317	R:R:P318	3.28	No	No	0	7	9
189	R:R:P318	R:R:T349	3.5	No	No	0	9	6
190	R:R:L352	R:R:P318	4.93	No	No	0	7	9
191	R:R:H320	R:R:Y319	7.62	Yes	Yes	1	7	6
192	R:R:R322	R:R:Y319	7.2	Yes	Yes	1	5	6
193	R:R:R323	R:R:Y319	7.2	Yes	Yes	1	6	6
194	R:R:H320	R:R:R323	3.39	Yes	Yes	1	7	6
195	R:R:R322	R:R:Y342	10.29	Yes	Yes	1	5	4
196	R:R:F345	R:R:R322	5.34	No	Yes	1	4	5
197	R:R:R322	R:R:Y346	12.35	Yes	Yes	1	5	4
198	R:R:R322	R:R:T349	9.06	Yes	No	1	5	6
199	R:R:L324	R:R:Y328	8.21	No	Yes	0	6	5
200	R:R:F326	R:R:Y342	7.22	Yes	Yes	0	4	4
201	R:R:I329	R:R:Q333	5.49	No	No	0	3	1
202	R:R:I329	R:R:W334	12.92	No	Yes	0	3	4
203	R:R:L338	R:R:W334	4.56	No	Yes	0	1	4
204	R:R:P336	R:R:T335	3.5	No	No	0	4	4
205	R:R:L338	R:R:T335	4.42	No	No	0	1	4
206	R:R:H343	R:R:Y339	15.24	Yes	Yes	1	4	2
207	R:R:H343	R:R:Y342	6.53	Yes	Yes	1	4	4
208	R:R:M347	R:R:Y344	3.59	No	Yes	0	3	1
209	R:R:F345	R:R:T349	7.78	No	No	1	4	6
210	R:R:N350	R:R:Y346	10.47	No	Yes	0	6	4
211	R:R:F353	R:R:Y354	7.22	No	Yes	0	7	7
212	R:R:F371	R:R:Y364	4.13	Yes	No	0	8	9
213	R:R:F371	R:R:N365	9.67	Yes	No	0	8	7
214	R:R:F375	R:R:N365	22.96	Yes	No	0	7	7
215	R:R:L366	R:R:V367	4.47	No	No	0	6	7
216	R:R:F375	R:R:L379	3.65	Yes	No	0	7	7
217	R:R:V304	R:R:V367	3.21	Yes	No	0	8	7
218	R:R:S357	R:R:T115	3.2	No	No	0	9	7
219	R:R:G220	R:R:H218	3.18	No	Yes	0	5	3
220	R:R:G221	R:R:H218	3.18	No	Yes	0	2	3
221	R:R:T378	R:R:V83	3.17	No	No	0	5	6
222	R:R:T264	R:R:V302	3.17	No	No	0	5	7
223	R:R:A109	R:R:L85	3.15	No	No	0	9	8
224	R:R:A260	R:R:L305	3.15	No	No	0	6	8
225	R:R:I189	R:R:S107	3.1	No	No	0	7	9
226	R:R:I192	R:R:S161	3.1	No	No	0	7	7
227	R:R:I237	R:R:V233	3.07	No	No	0	6	5
228	R:R:M249	R:R:S253	3.07	No	No	0	6	5
229	R:R:I374	R:R:T87	3.04	No	No	0	6	7
230	R:R:I228	R:R:T206	3.04	No	No	0	5	5
231	R:R:M249	R:R:V313	3.04	No	No	0	6	7
232	R:R:F136	R:R:W134	3.01	No	Yes	0	7	8
233	R:R:F136	R:R:G140	3.01	No	No	0	7	6
234	R:R:L94	R:R:S96	3	No	No	0	5	6
235	R:R:L73	R:R:V355	2.98	No	No	0	7	5
236	R:R:L255	R:R:V164	2.98	No	No	0	7	7
237	R:R:L263	R:R:V302	2.98	No	No	0	8	7
238	R:R:L317	R:R:V321	2.98	No	No	0	7	5
239	R:R:L124	R:R:T67	2.95	No	No	0	6	6
240	R:R:L113	R:R:T78	2.95	No	No	3	7	6
241	R:R:L117	R:R:T78	2.95	No	No	3	5	6
242	R:R:L113	R:R:T82	2.95	No	No	0	7	4
243	R:R:L88	R:R:T84	2.95	No	Yes	0	7	9
244	R:R:A231	R:R:H229	2.93	No	No	0	1	4
245	R:R:I128	R:R:K63	2.91	No	No	0	4	5
246	R:R:Q333	R:R:S330	2.89	No	No	0	1	2
247	R:R:L168	R:R:M180	2.83	No	No	0	4	7
248	R:R:L298	R:R:M266	2.83	Yes	No	0	7	6
249	R:R:L324	R:R:M325	2.83	No	No	0	6	4
250	R:R:I374	R:R:N370	2.83	No	No	0	6	7
251	R:R:G137	R:R:W134	2.81	No	Yes	0	8	8
252	R:R:H218	R:R:S213	2.79	Yes	No	0	3	1
253	L:L:K2	R:R:D331	2.77	Yes	No	0	0	1
254	R:R:L110	R:R:L114	2.77	No	No	0	6	8
255	R:R:L114	R:R:L118	2.77	No	No	0	8	5
256	R:R:H300	R:R:V367	2.77	No	No	0	8	7
257	L:L:K1	R:R:E53	2.7	No	No	0	0	2
258	R:R:C327	R:R:Y328	2.69	No	Yes	0	3	5
259	R:R:R184	R:R:S181	2.64	No	No	0	5	8
260	R:R:F371	R:R:S368	2.64	Yes	No	0	8	8
261	R:R:F247	R:R:V251	2.62	No	No	0	6	6
262	R:R:E272	R:R:Q269	2.55	No	No	0	5	7
263	R:R:T185	R:R:Y103	2.5	No	Yes	0	7	5
264	R:R:H300	R:R:Q296	2.47	No	No	0	8	5
265	R:R:F375	R:R:L376	2.44	Yes	No	0	7	4
266	R:R:D340	R:R:Y339	2.3	No	Yes	0	1	2
267	R:R:H172	R:R:Y167	2.18	No	Yes	0	6	8
268	R:R:G280	R:R:G281	2.11	No	No	7	5	5
269	R:R:A219	R:R:G220	1.95	No	No	0	1	5
270	R:R:A160	R:R:P248	1.87	No	Yes	0	8	9
271	R:R:G77	R:R:V76	1.84	No	No	0	8	6
272	R:R:G280	R:R:V279	1.84	No	No	0	5	6
273	R:R:G301	R:R:V304	1.84	No	Yes	0	8	8
274	R:R:G280	R:R:T278	1.82	No	No	7	5	4
275	R:R:G281	R:R:T278	1.82	No	No	7	5	4
276	R:R:A150	R:R:A200	1.79	No	No	0	6	7
277	R:R:P202	R:R:V201	1.77	No	No	0	7	5
278	R:R:G106	R:R:L85	1.71	No	No	0	6	8
279	R:R:G106	R:R:L88	1.71	No	No	0	6	7
280	R:R:A270	R:R:V295	1.7	No	No	0	5	3
281	R:R:M120	R:R:P121	1.68	Yes	No	0	8	9
282	R:R:D215	R:R:G216	1.68	No	No	0	2	2
283	R:R:S181	R:R:S183	1.63	No	No	0	8	4
284	R:R:A311	R:R:I359	1.62	No	No	0	7	6
285	R:R:V75	R:R:V76	1.6	No	No	0	5	6
286	R:R:V159	R:R:V308	1.6	No	No	0	8	8
287	R:R:V235	R:R:V239	1.6	No	No	0	4	5
288	R:R:V250	R:R:V254	1.6	No	No	0	3	5
289	R:R:S253	R:R:T257	1.6	No	No	0	5	3
290	R:R:V304	R:R:V308	1.6	Yes	No	0	8	8
291	R:R:T206	R:R:V233	1.59	No	No	0	5	5
292	R:R:A307	R:R:L363	1.58	No	No	0	7	8
293	R:R:A139	R:R:D138	1.54	No	No	0	1	3
294	R:R:I246	R:R:V250	1.54	No	No	0	5	3
295	R:R:I258	R:R:V254	1.54	No	No	0	5	5
296	R:R:I310	R:R:V314	1.54	No	No	0	5	6
297	R:R:I359	R:R:V355	1.54	No	No	0	6	5
298	R:R:H218	R:R:P50	1.53	Yes	No	0	3	4
299	R:R:H172	R:R:P173	1.53	No	No	0	6	8
300	R:R:F146	R:R:G143	1.51	No	No	0	6	5
301	R:R:L97	R:R:S96	1.5	No	No	0	8	6
302	R:R:L65	R:R:V69	1.49	No	No	0	5	4
303	R:R:L73	R:R:V69	1.49	No	No	0	7	4
304	R:R:L198	R:R:V201	1.49	No	No	0	4	5
305	R:R:N261	R:R:V265	1.48	No	No	0	4	4
306	R:R:D55	R:R:S52	1.47	No	No	0	3	6
307	R:R:L71	R:R:T67	1.47	No	No	0	5	6
308	R:R:L97	R:R:T100	1.47	No	No	0	8	7
309	R:R:L179	R:R:T178	1.47	No	No	0	4	4
310	R:R:D215	R:R:S213	1.47	No	No	0	2	1
311	R:R:E332	R:R:S330	1.44	No	No	0	1	2
312	R:R:I192	R:R:L157	1.43	No	No	0	7	6
313	R:R:K175	R:R:L179	1.41	No	No	0	4	4
314	R:R:L194	R:R:L198	1.38	No	No	0	3	4
315	R:R:A369	R:R:R372	1.38	No	No	0	4	9
316	R:R:L379	R:R:L382	1.38	No	No	0	7	3
317	R:R:H229	R:R:T232	1.37	No	No	0	4	4
318	R:R:D55	R:R:N57	1.35	No	No	0	3	2
319	R:R:A135	R:R:Y125	1.33	No	No	0	3	5
320	R:R:E165	R:R:L168	1.33	Yes	No	0	8	4
321	R:R:R182	R:R:S181	1.32	Yes	No	0	3	8
322	R:R:R268	R:R:V265	1.31	No	No	0	4	4
323	R:R:F337	R:R:T335	1.3	No	No	0	2	4
324	R:R:Q269	R:R:Q273	1.28	No	No	0	7	4
325	R:R:V64	R:R:W129	1.23	No	No	0	6	5
326	R:R:L298	R:R:R294	1.21	Yes	No	0	7	4
327	R:R:L376	R:R:R372	1.21	No	No	0	4	9
328	R:R:H373	R:R:R372	1.13	No	No	0	4	9
329	R:R:R303	R:R:R306	1.07	No	No	0	7	5
330	R:R:F341	R:R:F345	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:K2	6.58	4	1	0
2	L:L:P3	8.438	5	1	0
3	L:L:Y4	6.208	5	0	0
4	L:L:L6	7.3925	4	1	0
5	R:R:Y70	4.686	5	0	7
6	R:R:T84	4.1875	4	0	9
7	R:R:Y103	4.775	4	4	5
8	R:R:H104	7.3575	4	0	8
9	R:R:D112	6.2775	4	0	9
10	R:R:M120	4.6575	4	0	8
11	R:R:E123	6.9325	4	0	6
12	R:R:N126	6.84	4	1	5
13	R:R:F127	6.04167	6	1	4
14	R:R:H132	7.208	5	0	4
15	R:R:W134	8.19333	6	1	8
16	R:R:Y153	9.52	4	1	7
17	R:R:N158	6.11	4	5	8
18	R:R:E165	5.015	4	0	8
19	R:R:Y167	4.638	5	0	8
20	R:R:R182	4.175	4	4	3
21	R:R:W193	5.96	4	5	9
22	R:R:H218	2.67	4	0	3
23	R:R:T225	7.11	4	2	4
24	R:R:P226	5.7975	4	0	5
25	R:R:P248	3.93	4	0	9
26	R:R:N256	6.475	4	0	9
27	R:R:L298	3.5125	4	0	7
28	R:R:V304	2.78	4	0	8
29	R:R:F312	6.33	4	0	9
30	R:R:W316	7.135	4	0	8
31	R:R:Y319	6.535	4	1	6
32	R:R:H320	6.592	5	1	7
33	R:R:R322	8.848	5	1	5
34	R:R:R323	6.456	5	1	6
35	R:R:F326	8.4	4	0	4
36	R:R:Y328	5.61	4	6	5
37	R:R:W334	11.9525	4	1	4
38	R:R:Y339	8.71	5	1	2
39	R:R:Y342	9.14	4	1	4
40	R:R:H343	11.7775	4	1	4
41	R:R:Y344	6.1225	4	0	1
42	R:R:Y346	9.795	4	1	4
43	R:R:Y354	8.2675	4	0	7
44	R:R:F371	5.882	5	0	8
45	R:R:F375	9.5575	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P3	R:R:Y342	23.5226	12.52	Yes	Yes	1	0	4
2	L:L:P3	R:R:W334	15.9767	17.57	Yes	Yes	1	0	4
3	L:L:I5	L:L:Y4	24.9851	7.25	No	Yes	0	0	0
4	L:L:Y4	R:R:L54	20.5406	7.03	Yes	No	0	0	5
5	R:R:R322	R:R:Y342	35.4048	10.29	Yes	Yes	1	5	4
6	R:R:R322	R:R:Y346	34.8528	12.35	Yes	Yes	1	5	4
7	R:R:F127	R:R:Y346	17.3993	10.32	Yes	Yes	1	4	4
8	L:L:I5	R:R:F127	18.8846	6.28	No	Yes	1	0	4
9	L:L:L6	R:R:F326	11.6318	14.61	Yes	Yes	0	0	4
10	R:R:M207	R:R:P226	16.5173	10.06	No	Yes	0	6	5
11	L:L:L6	R:R:R323	11.2022	4.86	Yes	Yes	1	0	6
12	R:R:R322	R:R:Y319	20.6231	7.2	Yes	Yes	1	5	6
13	R:R:H132	R:R:L54	19.5675	7.71	Yes	No	0	4	5
14	R:R:N350	R:R:Y346	21.656	10.47	No	Yes	0	6	4
15	R:R:N350	R:R:Y70	10.9632	3.49	No	Yes	0	6	7
16	R:R:V66	R:R:Y70	10.4709	8.83	No	Yes	0	5	7
17	R:R:R148	R:R:Y319	22.6718	4.12	No	Yes	0	7	6
18	R:R:A119	R:R:R148	21.9007	4.15	No	No	0	7	7
19	R:R:A119	R:R:Y354	22.2706	4	No	Yes	0	7	7
20	R:R:F353	R:R:Y354	100	7.22	No	Yes	0	7	7
21	R:R:F353	R:R:W316	99.7838	8.02	No	Yes	0	7	8
22	R:R:S356	R:R:W316	13.2451	8.65	No	Yes	0	9	8
23	R:R:C315	R:R:S356	12.1724	5.16	No	No	0	9	9
24	R:R:C315	R:R:V355	11.094	3.42	No	No	0	9	5
25	R:R:E123	R:R:F127	56.9356	5.83	Yes	Yes	0	6	4
26	R:R:E123	R:R:Y354	68.4507	13.47	Yes	Yes	0	6	7
27	R:R:E123	R:R:N350	14.9523	3.94	Yes	No	0	6	6
28	R:R:T155	R:R:W316	93.9309	4.85	No	Yes	0	9	8
29	R:R:D112	R:R:T155	59.448	7.23	Yes	No	0	9	9
30	R:R:D112	R:R:N81	53.8114	6.73	Yes	No	0	9	9
31	R:R:N81	R:R:P361	26.5073	6.52	No	No	0	9	9
32	R:R:A109	R:R:N81	26.5073	4.69	No	No	0	9	9
33	R:R:A109	R:R:T84	23.679	3.36	No	Yes	0	9	9
34	R:R:F371	R:R:T84	37.8944	5.19	Yes	Yes	0	8	9
35	R:R:F371	R:R:N365	20.2475	9.67	Yes	No	0	8	7
36	R:R:F375	R:R:N365	18.2473	22.96	Yes	No	0	7	7
37	R:R:P361	R:R:T84	23.7673	5.25	No	Yes	0	9	9
38	R:R:S111	R:R:T155	53.0232	6.4	No	No	0	8	9
39	R:R:N158	R:R:S111	52.1895	4.47	Yes	No	0	8	8
40	R:R:N158	R:R:S107	21.7072	8.94	Yes	No	5	8	9
41	R:R:I189	R:R:S107	21.1894	3.1	No	No	0	7	9
42	R:R:H104	R:R:I189	20.2362	11.93	Yes	No	0	8	7
43	R:R:E165	R:R:H104	36.21	7.39	Yes	Yes	0	8	8
44	R:R:E165	R:R:T100	28.4308	7.06	Yes	No	0	8	7
45	R:R:T100	R:R:T185	18.4094	9.42	No	No	0	7	7
46	R:R:T185	R:R:Y103	16.3864	2.5	No	Yes	0	7	5
47	R:R:R182	R:R:Y103	10.2689	4.12	Yes	Yes	4	3	5
48	R:R:I192	R:R:N158	22.797	4.25	No	Yes	0	7	8
49	R:R:I192	R:R:S161	20.8906	3.1	No	No	0	7	7
50	R:R:H104	R:R:S161	19.9346	5.58	Yes	No	0	8	7
51	R:R:F127	R:R:W134	14.3349	4.01	Yes	Yes	1	4	8
52	R:R:G220	R:R:H132	13.6093	4.77	No	Yes	0	5	4
53	R:R:G220	R:R:H218	11.5777	3.18	No	Yes	0	5	3
54	R:R:H320	R:R:Y319	13.1484	7.62	Yes	Yes	1	7	6
55	R:R:F312	R:R:W316	37.7778	7.02	Yes	Yes	0	9	8
56	R:R:F312	R:R:I252	29.0994	7.54	Yes	No	0	9	8
57	R:R:I252	R:R:V159	11.0997	4.61	No	No	0	8	8
58	R:R:F245	R:R:H320	16.6368	6.79	No	Yes	0	8	7
59	R:R:F245	R:R:I246	15.0548	3.77	No	No	0	8	5
60	R:R:I246	R:R:V250	13.3874	1.54	No	No	0	5	3
61	R:R:V250	R:R:V254	12.9435	1.6	No	No	0	3	5
62	R:R:I258	R:R:V254	12.8695	1.54	No	No	0	5	5
63	R:R:I258	R:R:Y167	12.8183	3.63	No	Yes	0	5	8
64	R:R:L255	R:R:Y167	14.113	7.03	No	Yes	0	7	8
65	R:R:I252	R:R:N256	19.0923	5.66	No	Yes	0	8	9
66	R:R:N256	R:R:S163	15.4617	8.94	Yes	No	0	9	9
67	R:R:L255	R:R:S163	14.7105	4.5	No	No	0	7	9
68	R:R:C171	R:R:Y167	15.5015	6.72	No	Yes	0	7	8
69	R:R:C171	R:R:K262	14.4146	3.23	No	No	0	7	5
70	R:R:P226	R:R:V233	22.7031	5.3	Yes	No	0	5	5
71	R:R:T206	R:R:V233	13.3931	1.59	No	No	0	5	5
72	R:R:K262	R:R:M266	13.3561	7.2	No	No	0	5	6
73	R:R:L298	R:R:M266	12.2549	2.83	Yes	No	0	7	6
74	R:R:V159	R:R:V308	10.01	1.6	No	No	0	8	8
75	R:R:I329	R:R:W334	10.2518	12.92	No	Yes	0	3	4
76	R:R:L338	R:R:W334	10.2518	4.56	No	Yes	0	1	4
77	R:R:F127	R:R:Y145	23.1384	6.19	Yes	No	1	4	4
78	R:R:M120	R:R:Y354	13.965	8.38	Yes	Yes	0	8	7
79	R:R:M207	R:R:Y145	13.413	13.17	No	No	1	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K1	R:R:Y339	15.53	0	No	Yes	0	2	0	1
L:L:K2	R:R:F326	7.44	1	Yes	Yes	0	4	0	1
L:L:K2	R:R:W334	12.76	1	Yes	Yes	0	4	0	1
L:L:P3	R:R:W334	17.57	1	Yes	Yes	0	4	0	1
L:L:P3	R:R:Y339	4.17	1	Yes	Yes	0	2	0	1
L:L:P3	R:R:Y342	12.52	1	Yes	Yes	0	4	0	1
L:L:P3	R:R:H343	4.58	1	Yes	Yes	0	4	0	1
L:L:Y4	R:R:L54	7.03	0	Yes	No	0	5	0	1
L:L:Y4	R:R:H131	5.44	0	Yes	No	0	3	0	1
L:L:Y4	R:R:V223	7.57	0	Yes	No	0	4	0	1
L:L:Y4	R:R:T225	3.75	0	Yes	Yes	0	4	0	1
L:L:I5	R:R:F127	6.28	1	No	Yes	0	4	0	1
L:L:I5	R:R:Y346	6.04	1	No	Yes	0	4	0	1
L:L:L6	R:R:Y145	5.86	1	Yes	No	0	4	0	1
L:L:L6	R:R:M207	4.24	1	Yes	No	0	6	0	1
L:L:L6	R:R:R323	4.86	1	Yes	Yes	0	6	0	1
L:L:L6	R:R:F326	14.61	1	Yes	Yes	0	4	0	1
R:R:H132	R:R:L54	7.71	0	Yes	No	4	5	2	1
R:R:H131	R:R:V56	11.07	0	No	No	3	2	1	2
R:R:V56	R:R:Y339	6.31	1	No	Yes	2	2	2	1
R:R:H343	R:R:V56	20.76	1	Yes	No	4	2	1	2
R:R:E123	R:R:F127	5.83	0	Yes	Yes	6	4	2	1
R:R:E123	R:R:N350	3.94	0	Yes	No	6	6	2	2
R:R:F127	R:R:N126	3.62	1	Yes	Yes	4	5	1	2
R:R:N126	R:R:W134	15.82	1	Yes	Yes	5	8	2	2
R:R:F127	R:R:W134	4.01	1	Yes	Yes	4	8	1	2
R:R:F127	R:R:Y145	6.19	1	Yes	No	4	4	1	1
R:R:F127	R:R:Y346	10.32	1	Yes	Yes	4	4	1	1
R:R:M207	R:R:Y145	13.17	1	No	No	6	4	1	1
R:R:D149	R:R:N240	4.04	1	No	No	5	6	2	2
R:R:D149	R:R:R323	3.57	1	No	Yes	5	6	2	1
R:R:M207	R:R:P226	10.06	1	No	Yes	6	5	1	2
R:R:Q210	R:R:R212	10.51	2	No	No	1	1	2	2
R:R:Q210	R:R:T225	5.67	2	No	Yes	1	4	2	1
R:R:R212	R:R:V223	5.23	2	No	No	1	4	2	1
R:R:R212	R:R:T225	15.52	2	No	Yes	1	4	2	1
R:R:P226	R:R:T225	3.5	0	Yes	Yes	5	4	2	1
R:R:F326	R:R:P226	4.33	0	Yes	Yes	4	5	1	2
R:R:N240	R:R:R323	13.26	1	No	Yes	6	6	2	1
R:R:H320	R:R:Y319	7.62	1	Yes	Yes	7	6	2	2
R:R:R322	R:R:Y319	7.2	1	Yes	Yes	5	6	2	2
R:R:R323	R:R:Y319	7.2	1	Yes	Yes	6	6	1	2
R:R:H320	R:R:R323	3.39	1	Yes	Yes	7	6	2	1
R:R:R322	R:R:Y342	10.29	1	Yes	Yes	5	4	2	1
R:R:R322	R:R:Y346	12.35	1	Yes	Yes	5	4	2	1
R:R:F326	R:R:Y342	7.22	0	Yes	Yes	4	4	1	1
R:R:I329	R:R:W334	12.92	0	No	Yes	3	4	2	1
R:R:L338	R:R:W334	4.56	0	No	Yes	1	4	2	1
R:R:H343	R:R:Y339	15.24	1	Yes	Yes	4	2	1	1
R:R:H343	R:R:Y342	6.53	1	Yes	Yes	4	4	1	1
R:R:N350	R:R:Y346	10.47	0	No	Yes	6	4	2	1
L:L:K2	R:R:D331	2.77	1	Yes	No	0	1	0	1
L:L:K1	R:R:E53	2.7	0	No	No	0	2	0	1
R:R:D340	R:R:Y339	2.3	0	No	Yes	1	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6OSA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	301
Number of Links	330
Number of Hubs	45
Number of Links mediated by Hubs	159
Number of Communities	7
Number of Nodes involved in Communities	46
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	69309
Length Of Smallest Path	3
Average Path Length	14.4584
Length of Longest Path	30
Minimum Path Strength	1.17
Average Path Strength	6.45202
Maximum Path Strength	17.705
Minimum Path Correlation	0.7
Average Path Correlation	0.936569
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	53.2347
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6012
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adult locomotory behavior • behavior • multicellular organismal process • adult behavior • locomotory behavior • system process • learning • learning or memory • nervous system process • cognition • regulation of calcium ion transport • regulation of localization • intracellular calcium ion homeostasis • negative regulation of biological process • negative regulation of transport • calcium ion transport • localization • negative regulation of cation transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • negative regulation of calcium ion transmembrane transport • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • positive regulation of biological process • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • negative regulation of transmembrane transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of sequestering of calcium ion • negative regulation of monoatomic ion transmembrane transport • negative regulation of release of sequestered calcium ion into cytosol • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • negative regulation of cellular process • monoatomic ion transport • intracellular chemical homeostasis • regulation of metal ion transport • regulation of sequestering of calcium ion • positive regulation of cellular process • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • negative regulation of calcium ion transport • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • regulation of postsynaptic membrane potential • regulation of system process • regulation of signal transduction • chemical synaptic transmission, postsynaptic • synaptic signaling • positive regulation of inhibitory postsynaptic potential • positive regulation of nervous system process • regulation of multicellular organismal process • regulation of biological quality • modulation of inhibitory postsynaptic potential • trans-synaptic signaling • regulation of signaling • cell surface receptor signaling pathway • cell-cell signaling • regulation of nervous system process • chemical synaptic transmission • regulation of response to stimulus • anterograde trans-synaptic signaling • inhibitory postsynaptic potential • positive regulation of multicellular organismal process • regulation of cell communication • regulation of membrane potential • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of programmed cell death • positive regulation of apoptotic process • organic acid transmembrane transport • import into cell • nitrogen compound transport • organic anion transport • carboxylic acid transport • carboxylic acid transmembrane transport • aspartate transmembrane transport • import across plasma membrane • amino acid transmembrane transport • C4-dicarboxylate transport • D-amino acid transport • organic acid transport • amino acid transport • D-aspartate transmembrane transport • D-aspartate import across plasma membrane • dicarboxylic acid transport • amino acid import across plasma membrane • positive regulation of arachidonate secretion • regulation of lipid transport • regulation of arachidonate secretion • arachidonate secretion • monocarboxylic acid transport • positive regulation of secretion • fatty acid transport • icosanoid transport • regulation of icosanoid secretion • icosanoid secretion • long-chain fatty acid transport • positive regulation of icosanoid secretion • secretion • arachidonate transport • lipid localization • lipid transport • positive regulation of lipid localization • regulation of fatty acid transport • regulation of secretion • positive regulation of organic acid transport • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • regulation of membrane depolarization • membrane depolarization • polyol metabolic process • alcohol catabolic process • catabolic process • polyol catabolic process • organophosphate catabolic process • alcohol metabolic process • inositol phosphate metabolic process • organophosphate metabolic process • phosphate-containing compound metabolic process • inositol phosphate catabolic process • small molecule metabolic process • small molecule catabolic process • phosphorus metabolic process • detection of external stimulus • detection of stimulus involved in sensory perception of pain • response to external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • L-amino acid transport • L-glutamate import • L-glutamate import across plasma membrane • acidic amino acid transport • L-alpha-amino acid transmembrane transport • L-glutamate transmembrane transport • multicellular organismal-level homeostasis • temperature homeostasis • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • negative regulation of systemic arterial blood pressure • blood circulation • negative regulation of blood pressure • positive regulation of amine transport • gamma-aminobutyric acid transport • regulation of amino acid transport • gamma-aminobutyric acid secretion • regulation of gamma-aminobutyric acid secretion • positive regulation of gamma-aminobutyric acid secretion • acid secretion • amine transport • positive regulation of amino acid transport • regulation of amine transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • response to lipid • response to chemical • regulation of glutamate secretion • positive regulation of secretion by cell • secretion by cell • regulation of secretion by cell • glutamate secretion • positive regulation of glutamate secretion • export from cell • regulation of inositol phosphate biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • regulation of phosphate metabolic process • polyol biosynthetic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • symmetric synapse • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • neuron projection • axon terminus • plasma membrane bounded cell projection • presynapse
Gene Ontology	Cellular Component	• symmetric synapse • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • neuron projection • axon terminus • plasma membrane bounded cell projection • presynapse • cell projection • distal axon • terminal bouton • neuron projection terminus • cell surface • cell periphery • plasma membrane • membrane • membrane microdomain • membrane raft • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • dendrite • dendritic tree • dendritic shaft • neuron spine • dendritic spine • postsynapse • cytoplasmic side of plasma membrane • cytoplasmic side of membrane • side of membrane • endoplasmic reticulum • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • membrane protein complex • heterotrimeric G-protein complex • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30989
Sequence	>6OSA_nogp_Chain_R P S S E L D V N T D I Y S K V L V T A V Y L A L F V V G T V G N T V T L F T L A R K K S L Q S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V H H P W A F G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A V P M L F T M G E Q N R S A D G Q H A G G L V C T P T I H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q C T V G G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I S D E Q W T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F R H I F L A T L A C L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	PubChem 118610427	-	3.02	2023-08-09	10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPC (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg		3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPB (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg		3.07	2023-08-09	10.1038/s41586-023-06395-9
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi1-Go)/β1/γ2	2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8FN1 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	PubChem 118610427	chim(NtGi1-Go)/β1/γ2	2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	PubChem 118610427		2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.59	2023-03-29	10.1021/acs.biochem.3c00029
	8FMZ (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.59	2023-03-29	10.1021/acs.biochem.3c00029
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	10.1038/s41594-022-00859-8
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	10.1126/sciadv.abe5504
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	10.1126/sciadv.abe5504
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.5	2021-01-06	10.1038/s41594-020-00554-6
	7L0S (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.5	2021-01-06	10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0R (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.1	2021-01-06	10.1038/s41594-020-00554-6
	7L0P (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.1	2021-01-06	10.1038/s41594-020-00554-6
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	10.1038/s41586-020-1953-1
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	10.1038/s41422-019-0256-2
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OSA (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	10.1038/s41586-019-1337-6
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OS9 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	10.1038/s41586-019-1337-6
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	10.1038/srep38564
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	10.1038/ncomms8895
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	10.1038/ncomms8895
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	10.1073/pnas.1317903111
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	10.1073/pnas.1317903111
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin-(8-13)	-	-	2.8	2012-10-17	10.1038/nature11558

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